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All rights reserved.Ingenuity Canonical Pathways -log(p-value)Ratioz-score Molecules3Hepatic Fibrosis / Hepatic Stellate Cell ActivationACTA2,CCN2,COL10A1,COL11A1,COL12A1,COL18A1,COL1A1,COL1A2,COL24A1,COL2A1,COL3A1,COL4A6,COL5A1,COL5A2,COL5A3,COL6A3,COL9A3,EDNRA,EDNRB,FGF1,FN1,HGF,IGF1,IGF2,IGFBP4,IGFBP5,IL1A,IL1R2,LEP,MYH11,MYH13,MYH4,MYH8,MYL3,NGFR,PDGFRA,PDGFRB,PROK1,TGFB3,VEGFDWound Healing Signaling PathwayACTA2,CALCA,CMA1,COL10A1,COL11A1,COL12A1,COL18A1,COL1A1,COL1A2,COL24A1,COL2A1,COL3A1,COL4A6,COL5A1,COL5A2,COL5A3,COL6A3,COL9A3,FGF7,FN1,IL12A,IL17B,IL1A,IL1R2,IL33,IL36G,KRT16,KRT6A,LAMA2,LEP,MMP10,NGFR,PROK1,RASD1,TAC1,TGFB3,TNFSF11,TNFSF9,TRPA1,VEGFD(Dilated Cardiomyopathy Signaling PathwayACTA1,ACTA2,ACTG2,ADCY1,ADCY5,ADCY8,ADRB1,CACNA1C,CACNA1G,CACNA1H,CACNA2D2,CACNG5,CACNG8,CNN1,DES,GUCY1A1,LAMA4,MYH11,MYH13,MYH4,MYH8,MYL3,PDE2A,PLN,RBM20,SGCD,TNNI3,TNNT2CREB Signaling in NeuronsACKR1,ACKR4,ADCY1,ADCY5,ADCY8,ADCYAP1R1,ADGRA2,ADGRB1,ADRA2A,ADRB1,ADRB3,APLNR,AVPR1A,AVPR2,CACNA1C,CACNA1G,CACNA1H,CACNA2D2,CACNG5,CACNG8,CALCR,CCKAR,CX3CR1,EDNRA,EDNRB,F2R,F2RL2,GLP2R,GNG4,GPR142,GPR63,GRIA1,GRIA2,GRIA3,GRID1,GRIK3,GRIN2C,GRPR,GUCY1A1,HGF,HTR1F,HTR6,IGF1,LGR5,LPAR4,MAS1L,MC5R,NGFR,NPY4R/NPY4R2,NTRK1,OXTR,P2RY12,PDGFRA,PDGFRB,PLCL1,PTGDR,PTGER3,PTH1R,RASD1,RXFP3,S1PR1,SLC52A1,XCR1'Cellular Effects of Sildenafil (Viagra)ACTA1,ACTA2,ACTG2,ADCY1,ADCY5,ADCY8,CACNA1C,CACNA2D2,CACNG5,CACNG8,GUCY1A1,GUCY1A2,MYH11,MYH13,MYH4,MYH8,MYL3,MYLK,NPR1,PDE1A,PDE1B,PDE2A,PLCL1,PRKG19Airway Pathology in Chronic Obstructive Pulmonary DiseasetAMBP,APOD,CTSG,ELANE,FGF1,FGF10,FGF7,IL12A,IL17B,IL1A,IL33,IL36G,LCN10,LCN6,LEP,ORM1,ORM2,PTGDS,TGFB3,TNFSF11,TNFSF9Atherosclerosis SignalingAPOA2,APOD,APOF,CMA1,COL10A1,COL18A1,COL1A1,COL1A2,COL2A1,COL3A1,COL5A3,CXCL12,IL1A,IL33,IL36G,ORM1,ORM2,PLA2G2C,PLA2G4D,PLA2G5,PLAAT5,SELP$Agranulocyte Adhesion and DiapedesisACKR4,ACTA1,ACTA2,ACTG2,AOC3,CCL14,CCL16,CLDN18,CLDN5,CLDN6,CXCL10,CXCL12,CXCL14,CXCL5,CXCL6,FN1,IL1A,IL33,IL36G,MMP10,MMP11,MMP16,MYH11,MYH13,MYH4,MYH8,MYL3,SELP(Intrinsic Prothrombin Activation PathwayICOL10A1,COL18A1,COL1A1,COL1A2,COL2A1,COL3A1,COL5A3,F12,F5,KLK14,KLK2,KLK3Osteoarthritis PathwayACAN,ALPP,C1QTNF4,CCN4,CNMD,COL10A1,COL2A1,CTNNA2,DCN,FN1,FRZB,GLI2,GLIS1,GREM1,HTRA1,IL1R2,ITGA1,ITGA11,ITGA8,LEP,LRP1,MATN3,MMP10,NKX3-2,PROK1,PTH1R,RUNX2,SERPINA12,TIMP3,VEGFDApelin Liver Signaling Pathway?APLNR,COL10A1,COL18A1,COL1A1,COL1A2,COL2A1,COL3A1,COL5A3,PDGFRB'Amyotrophic Lateral Sclerosis SignalingxCACNA1C,CACNA2D2,CACNG5,CACNG8,CAPN11,CAPN3,CAPN8,GRIA1,GRIA2,GRIA3,GRID1,GRIK3,GRIN2C,IGF1,NEFH,NEFL,PROK1,SLC1A2,VEGFD%White Adipose Tissue Browning PathwayADCY1,ADCY5,ADCY8,ADRB3,CACNA1C,CACNA1G,CACNA1H,CACNA2D2,CACNG5,CACNG8,DIO2,GUCY1A1,GUCY1A2,LEP,LIPE,MS4A2,NDN,NPR1,PRDM16,PRKG1,RUNX1T1(Neurovascular Coupling Signaling PathwayCACNA1C,CACNA1G,CACNA1H,CACNA2D2,CACNG5,CACNG8,GABRA5,GABRE,GAD1,GAST,GRIA1,GRIA2,GRIA3,GRIN2C,GUCY1A1,GUCY1A2,KCNJ12,KCNJ8,KCNMA1,MAPT,NPR1,PLA2G2C,PLA2G4D,PLA2G5,PLAAT5,PRKG1,SLC1A2,SLCO2A1Circadian Rhythm SignalingADCY1,ADCY5,ADCY8,ADCYAP1R1,ADRB1,BLK,CACNA1C,CACNA1G,CACNA1H,CACNA2D2,CACNG5,CACNG8,GAD1,GAST,GNG4,GRIA1,GRIA2,GRIA3,GRIN2C,GRP,GRPR,GUCY1A1,GUCY1A2,KLK3,NGFR,NPR1,PLCL1,PRKG1,PTGDS,RASD1,TRPC6=Role Of Osteoclasts In Rheumatoid Arthritis Signaling PathwayADAM12,ADAM23,ADAM29,ADAM33,CALCR,COL10A1,COL11A1,COL12A1,COL18A1,COL1A1,COL1A2,COL24A1,COL2A1,COL3A1,COL4A6,COL5A1,COL5A2,COL5A3,COL6A3,COL9A3,CTNNA2,CTSK,FRZB,IL1R2,MMP10,MMP11,MMP16,NGFR,RASD1,RND1,SFRP2,SFRP4,TNFSF11/Pulmonary Fibrosis Idiopathic Signaling PathwayACTA1,ACTA2,ACTG2,CCN2,CCN4,COL10A1,COL11A1,COL12A1,COL18A1,COL1A1,COL1A2,COL24A1,COL2A1,COL3A1,COL4A6,COL5A1,COL5A2,COL5A3,COL6A3,COL9A3,CXCL12,EDNRA,F2R,FN1,GLI2,MMP10,MMP11,MMP16,NOX4,PDGFRA,PDGFRB,RASD1,SFTPA2,TGFB3,WNT9BNicotine Degradation IIRADH7,CYP1A1,CYP2C18,CYP2F1,CYP4B1,FMO1,INMT,LARGE1,UGT2B11,UGT2B15,UGT2B17,UGT2B281Pathogen Induced Cytokine Storm Signaling PathwayCCL14,CCL16,COL10A1,COL11A1,COL12A1,COL18A1,COL1A1,COL1A2,COL24A1,COL2A1,COL3A1,COL4A6,COL5A1,COL5A2,COL5A3,COL6A3,COL9A3,CXCL10,CXCL12,CXCL14,CXCL5,CXCL6,IL12A,IL17B,IL1A,IL1R2,IL33,IL36G,LEP,NGFR,NLRP4,PROK1,TGFB3,TNFSF11,TNFSF9,VEGFD,Oxytocin In Spinal Neurons Signaling Pathway6AVPR1A,GAD1,GAST,GUCY1A1,GUCY1A2,KCNJ8,NPR1,OXTR,PRKG1RAR ActivationADCY1,ADCY5,ADCY8,ADH1C,ADH7,ALDH1A3,BCO1,CNGB1,COL10A1,COL1A1,COL1A2,COL3A1,DLK1,ENPP1,FGF10,GATA4,GRIA1,GUCY1A1,IL12A,IL17B,IL1A,IL33,IL36G,LEP,LIPE,LRAT,MMP11,NR2F1,PAX6,PDE1A,PDE1B,PDE2A,PRDM16,RDH10,RND1,RPE65,TBX5,TGFB3,TNFSF11,TNFSF9,ZBTB16Gustation PathwayADCY1,ADCY5,ADCY8,ASIC2,CACNA1C,CACNA1G,CACNA1H,CACNA2D2,CACNG5,CACNG8,GABRA5,GABRE,GUCY1A1,KCNJ12,KCNJ8,LIPE,LIPF,LIPM,P2RY12,SCN2B,SCN3B,SCN4B,SCN7A,SCNN1A,SCNN1BPhagosome FormationjACKR1,ACKR4,ADCYAP1R1,ADGRA2,ADGRB1,ADRA2A,ADRB1,ADRB3,APLNR,AVPR1A,AVPR2,CALCR,CCKAR,CLEC4E,CX3CR1,EDNRA,EDNRB,F2R,F2RL2,FCER2,FN1,GLP2R,GPR142,GPR63,GRPR,HTR1F,HTR6,ITGA1,ITGA11,ITGA8,LGR5,LPAR4,MARCO,MAS1L,MC5R,MYH11,MYH13,MYH4,MYH8,MYL3,MYLK,NPY4R/NPY4R2,OXTR,P2RY12,PLA2G2C,PLA2G4D,PLA2G5,PLAAT5,PLD5,PTGDR,PTGER3,PTH1R,RASD1,RXFP3,S1PR1,SCARA5,SLC52A1,XCR1GP6 Signaling PathwayCOL10A1,COL11A1,COL12A1,COL18A1,COL1A1,COL1A2,COL24A1,COL2A1,COL3A1,COL4A6,COL5A1,COL5A2,COL5A3,COL6A3,COL9A3,LAMA2,LAMA4,RASGRP2S100 Family Signaling PathwayACKR1,ACKR4,ADCYAP1R1,ADGRA2,ADGRB1,ADRA2A,ADRB1,ADRB3,APLNR,AVPR1A,AVPR2,CACNA1C,CACNA1G,CACNA1H,CACNA2D2,CACNG5,CACNG8,CALCR,CCKAR,CX3CR1,DLC1,EDNRA,EDNRB,ESR1,F2R,F2RL2,GLP2R,GPR142,GPR63,GRPR,HTR1F,HTR6,KLK3,LGR5,LPAR4,MAS1L,MC5R,MMP10,MMP11,MMP16,NKX2-1,NOX4,NPY4R/NPY4R2,OXTR,P2RY12,PLA2G4D,PLA2G5,PLCL1,PROK1,PTGDR,PTGER3,PTH1R,RXFP3,S100A14,S100A2,S100Z,S1PR1,SLC52A1,TGFB3,VEGFD,WNT9B,XCR1Tumor Microenvironment PathwayzCOL1A1,COL1A2,COL3A1,CSPG4,CXCL12,FGF1,FGF10,FGF7,FN1,HGF,IDO1,IGF1,IGF2,LEP,MMP10,MMP11,MMP16,PROK1,RASD1,TGFB3,TNC,VEGFDSynaptic Long Term DepressionCACNA1C,CACNA1G,CACNA1H,CACNA2D2,CACNG5,CACNG8,GAD1,GAST,GRIA1,GRIA2,GRIA3,GRID1,GUCY1A1,GUCY1A2,IGF1,NPR1,PLA2G2C,PLA2G4D,PLA2G5,PLAAT5,PLCL1,PRKG1,RASD1!Activin Inhibin Signaling PathwayCCN2,CCNA1,COL10A1,COL18A1,COL1A1,COL1A2,COL2A1,COL3A1,COL5A3,FOSL1,IL1A,IL1R2,IL33,IL36G,KL,LIPE,NGFR,PAX1,PAX2,PAX3,PAX5,PAX6,SOX17,TGFB33Nitric Oxide Signaling in the Cardiovascular SystemgADRB1,ADRB3,CACNA1C,CACNA2D2,CACNG5,CACNG8,GUCY1A1,GUCY1A2,NPR1,PDE1A,PDE1B,PDE2A,PLN,PRKG1,PROK1,VEGFDNicotine Degradation IIIHADH7,CYP1A1,CYP2C18,CYP2F1,CYP4B1,LARGE1,UGT2B11,UGT2B15,UGT2B17,UGT2B28=Role Of Osteoblasts In Rheumatoid Arthritis Signaling PathwayCOL1A1,CTSG,CTSK,CXCL12,FRZB,IGF1,IL12A,IL17B,IL1A,IL33,IL36G,LEP,LRP1,MMP10,MMP11,MMP16,PROK1,RUNX2,SFRP2,SFRP4,TGFB3,TNFSF11,TNFSF9,VEGFD,WNT9BcAMP-mediated signalingADCY1,ADCY5,ADCY8,ADRA2A,ADRB1,ADRB3,AKAP12,APLNR,AVPR2,CNGB1,ENPP1,GUCY1A1,HTR1F,HTR6,MC5R,P2RY12,PALM2AKAP2,PDE1A,PDE1B,PDE2A,PTGDR,PTGER3,PTH1R,S1PR1,XCR1Axonal Guidance SignalingADAM12,ADAM23,ADAM29,ADAM33,ADAMTS12,ADAMTS14,ADAMTS15,ADAMTS16,ADAMTS7,ARHGEF15,BMP8A,CXCL12,EFNA2,GDF7,GLI2,GLIS1,GNG4,IGF1,ITGA1,ITGA11,ITGA8,KCNJ12,LRRC4C,MMP10,MMP11,MMP16,MYL3,NGFR,NRP1,NTN4,NTRK1,PAPPA2,PLCL1,PROK1,RASD1,RND1,SEMA5A,SEMA6D,SLIT2,SLIT3,UNC5C,VEGFD,WNT9BGap Junction SignalingACTA1,ACTA2,ACTG2,ADCY1,ADCY5,ADCY8,ADRB1,GAD1,GAST,GJA4,GJB1,GJB3,GRIA1,GRIA2,GRIA3,GRIK3,GUCY1A1,GUCY1A2,NPR1,PLCL1,PRKG1,RASD1OGPCR-Mediated Integration of Enteroendocrine Signaling Exemplified by an L CellFADCY1,ADCY5,ADCY8,ADRB1,ADRB3,CALCA,CCKAR,GLP2R,GRP,GRPR,GUCY1A1,PLCL1 SPINK1 Pancreatic Cancer Pathway3CPA3,CPB1,CPE,CPZ,ELANE,KLK14,KLK2,KLK3,PRSS1,PRSS3Calcium SignalingACTA1,ACTA2,CACNA1C,CACNA1G,CACNA1H,CACNA2D2,CACNG5,CACNG8,CASQ2,CHRNA9,GRIA1,GRIA2,GRIA3,GRIN2C,MYH11,MYH13,MYH4,MYH8,MYL3,SLC8A2,TNNI3,TNNT2,TRPC6$G-Protein Coupled Receptor SignalingTACKR1,ACKR4,ADCY1,ADCY5,ADCY8,ADCYAP1R1,ADGRA2,ADGRB1,ADRA2A,ADRB1,ADRB3,APLNR,AVPR1A,AVPR2,CALCR,CCKAR,CNGB1,CX3CR1,EDNRA,EDNRB,ENPP1,F2R,F2RL2,GLP2R,GNG4,GPR142,GPR63,GRPR,GUCY1A1,HCN4,HTR1F,HTR6,LGR5,LPAR4,MAS1L,MC5R,MEGF6,MYL3,MYLK,NPY4R/NPY4R2,OXTR,P2RY12,PDE1A,< PDE1B,PDE2A,PREX1,PREX2,PTGDR,PTGER3,PTH1R,RASD1,RXFP3,S1PR1,SLC52A1,XCR1"Hepatic Fibrosis Signaling PathwayACTA2,CACNA1C,CACNA2D2,CACNG5,CACNG8,CCN2,COL10A1,COL18A1,COL1A1,COL1A2,COL2A1,COL3A1,COL5A3,EDNRA,GLI2,GLIS1,IL1A,IL1R2,IL33,IL36G,ITGA1,ITGA11,ITGA8,LEP,LRP1,MYL3,MYLK,NGFR,NOX4,PDGFRA,PDGFRB,PROK1,RASD1,RND1,TGFB3,VEGFD,WNT9B#Granulocyte Adhesion and DiapedesiswACKR4,CCL14,CCL16,CLDN18,CLDN5,CLDN6,CXCL10,CXCL12,CXCL14,CXCL5,CXCL6,IL1A,IL1R2,IL33,IL36G,MMP10,MMP11,MMP16,NGFR,SELP%Inhibition of Matrix Metalloproteases/ADAM12,HSPG2,LRP1,MMP10,MMP11,MMP16,THBS2,TIMP3Oxytocin Signaling PathwayCACNA1C,CACNA2D2,CACNG5,CACNG8,GAD1,GAST,GNG4,GUCY1A1,GUCY1A2,HSPB7,KCNJ8,LEP,LIPE,MYH11,MYH13,MYH4,MYH8,MYL3,MYLK,NPR1,OXTR,PLA2G4D,PLA2G5,PPP1R14A,PRKG1,RASD1,TNFSF11(Cardiac Hypertrophy Signaling (Enhanced) ADCY1,ADCY5,ADCY8,ADRA2A,ADRB1,CACNA1C,CACNA2D2,CACNG5,CACNG8,EDNRA,EDNRB,ENPP1,FGF1,FGF10,FGF7,GATA4,GNG4,GUCY1A1,HSPB7,IGF1,IL12A,IL17B,IL1A,IL1R2,IL20RB,IL33,IL36G,ITGA1,ITGA11,ITGA8,LEP,NGFR,NPR1,PDE1A,PDE1B,PDE2A,PLCL1,PLN,PRKG1,RASD1,TGFB3,TNFSF11,TNFSF9,WNT9B FAK SignalingACKR1,ACKR4,ADCYAP1R1,ADGRA2,ADGRB1,ADRA2A,ADRB1,ADRB3,APLNR,AVPR1A,AVPR2,CALCR,CAPN11,CAPN3,CAPN8,CCKAR,COL10A1,COL18A1,COL1A1,COL1A2,COL2A1,COL3A1,COL5A3,CX3CR1,ECM2,EDNRA,EDNRB,EFNA2,F2R,F2RL2,GLP2R,GPR142,GPR63,GRPR,HTR1F,HTR6,IL1R2,IL20RB,IL33,ITGA1,ITGA11,ITGA8,LGR5,LPAR4,MAS1L,MC5R,NPY4R/NPY4R2,OXTR,P2RY12,PDGFRA,PDGFRB,PTGDR,PTGER3,PTH1R,RASD1,RXFP3,S1PR1,SLC52A1,SOCS2,SPARCL1,TGFB3,XCR1BThyroid Hormone Metabolism II (via Conjugation and/or Degradation)0DIO2,DIO3,LARGE1,UGT2B11,UGT2B15,UGT2B17,UGT2B28(Endocannabinoid Neuronal Synapse PathwaysADCY1,ADCY5,ADCY8,CACNA1C,CACNA1G,CACNA1H,CACNA2D2,CACNG5,CACNG8,DNALI1,GNG4,GRIA1,GRIA2,GRIA3,GRIN2C,GUCY1A1,PLCL1Melatonin Degradation ICCYP1A1,CYP2C18,CYP2F1,CYP4B1,LARGE1,UGT2B11,UGT2B15,UGT2B17,UGT2B28Cardiac -adrenergic SignalingADCY1,ADCY5,ADCY8,ADRB1,AKAP12,CACNA1C,CACNA2D2,CACNG5,CACNG8,ENPP1,GNG4,GUCY1A1,PALM2AKAP2,PDE1A,PDE1B,PDE2A,PLN,PPP1R14A,SLC8A2ABRA Signaling PathwayGACTA1,ACTA2,ACTG2,CCN2,GATA4,IGF1,MYH11,MYL3,PPP1R14A,PROK1,TAGLN,VEGFD%Breast Cancer Regulation by Stathmin1"ACKR1,ACKR4,ADCYAP1R1,ADGRA2,ADGRB1,ADRA2A,ADRB1,ADRB3,APLNR,ARHGEF15,AVPR1A,AVPR2,CALCR,CCKAR,CX3CR1,EDNRA,EDNRB,F2R,F2RL2,GLP2R,GNG4,GPR142,GPR63,GRPR,HGF,HTR1F,HTR6,IGF1,LGR5,LPAR4,MAS1L,MC5R,NPY4R/NPY4R2,OXTR,P2RY12,PPP1R14A,PROK1,PTGDR,PTGER3,PTH1R,RASD1,RXFP3,S1PR1,SLC52A1,VEGFD,XCR1GABA Receptor SignalingfADCY1,ADCY5,ADCY8,CACNA1C,CACNA1G,CACNA1H,CACNA2D2,CACNG5,CACNG8,GABRA5,GABRE,GAD1,GNG4,GUCY1A1,SLC6A1/Semaphorin Neuronal Repulsive Signaling Pathway_ACAN,BCAN,CSPG4,GUCY1A1,GUCY1A2,ITGA1,ITGA11,ITGA8,MAPT,MYL3,NRP1,PRKG1,RND1,SEMA5A,SEMA6D,VCAN%Superpathway of Melatonin DegradationSperm MotilityBLK,CACNA1G,CACNA1H,CNGB1,ERBB4,GNG4,GUCY1A1,GUCY1A2,NPR1,NTRK1,PDE1A,PDE1B,PDE2A,PDGFRA,PDGFRB,PLA2G2C,PLA2G4D,PLA2G5,PLAAT5,PLCL1,PRKG1,ROS1,TEK)Corticotropin Releasing Hormone SignalingiADCY1,ADCY5,ADCY8,CACNA1C,CACNA1G,CACNA1H,CACNA2D2,CACNG5,CACNG8,GAD1,GAST,GLI2,GUCY1A1,GUCY1A2,NPR1,UCN34Neuroprotective Role of THOP1 in Alzheimer's DiseaseHCMA1,CTSG,FAP,HTRA1,HTRA3,KLK3,MAPT,MASP1,PRSS1,PRSS12,PRSS23,PRSS3,TAC1Serotonin Receptor SignalingADCY1,ADCY5,ADCY8,ADRA2A,ADRB1,ADRB3,BLK,CACNA1C,CACNA1G,CACNA1H,CACNA2D2,CACNG5,CACNG8,CPE,GNG4,GUCY1A1,HTR6,IL12A,IL33,LEP,LIPE,MAPT,MYLK,PLA2G2C,PLA2G4D,PLA2G5,PLAAT5,PLCL1,PLD5,PLN,RASD1,RND1,TGFB3,TNNI3,TRPA1,TRPC61Maturity Onset Diabetes of Young (MODY) Signaling>APOA2,APOD,APOF,APOL5,BLK,CACNA1C,CACNA2D2,CACNG5,CACNG8,KCNJ8Hepatic CholestasisnADCY1,ADCY5,ADCY8,ESR1,GUCY1A1,IL12A,IL17B,IL1A,IL1R2,IL33,IL36G,LEP,NGFR,SLCO1B3,SLCO1C1,TGFB3,TNFSF11,TNFSF97GPCR-Mediated Nutrient Sensing in Enteroendocrine CellsXADCY1,ADCY5,ADCY8,CACNA1C,CACNA1G,CACNA1H,CACNA2D2,CACNG5,CACNG8,GAST,GNG4,GUCY1A1,PLCL1Serotonin Degradation9ADH1C,ADH7,ALDH1A3,LARGE1,UGT2B11,UGT2B15,UGT2B17,UGT2B28*Thyronamine and Iodothyronamine Metabolism DIO2,DIO3/Thyroid Hormone Metabolism I (via Deiodination)'nNOS Signaling in Skeletal Muscle Cells4CACNA1C,CACNA1G,CACNA1H,CACNA2D2,CACNG5,CACNG8,CAPN3MSP-RON Signaling Pathway+ACTA1,ACTA2,ACTG2,F12,IL12A,KLK14,KLK2,KLK3 Gs SignalingLADCY1,ADCY5,ADCY8,ADRB1,ADRB3,AVPR2,CNGB1,GNG4,GUCY1A1,HTR6,MC5R,PTGDR,PTH1R>Role Of Chondrocytes In Rheumatoid Arthritis Signaling PathwayNCXCL12,FN1,IL1A,IL1R2,IL33,IL36G,LRP1,MMP10,MMP11,MMP16,NGFR,PROK1,RUNX2,VEGFDRHOGDI SignalingpACTA1,ACTA2,ACTG2,ARHGAP6,ARHGEF15,CDH11,CDH12,DLC1,ESR1,GNG4,ITGA1,ITGA11,ITGA8,MYH11,MYH13,MYH4,MYH8,MYL3,RND1Glutamate Receptor Signaling0GNG4,GRIA1,GRIA2,GRIA3,GRID1,GRIK3,GRIN2C,SLC1A2SNARE Signaling PathwayNADCY1,ADCY5,ADCY8,CACNA2D2,GUCY1A1,MYH11,MYH13,MYH4,MYH8,MYL3,SYT10,SYT16,SYT9Retinol BiosynthesisBCO1,CES1,LIPE,LIPF,LRAT,RDH10Eicosanoid Signaling6DPEP1,PLA2G2C,PLA2G4D,PLA2G5,PLAAT5,PTGDR,PTGDS,PTGER3 Gi SignalingPADCY1,ADCY5,ADCY8,ADRA2A,APLNR,GNG4,GUCY1A1,HTR1F,P2RY12,PTGER3,RASD1,S1PR1,XCR1Tyrosine Degradation IHGD,TATAirway Inflammation in AsthmaELANE,IL12A,IL33,PRG2,TGFB3Protein Kinase A SignalingADCY1,ADCY5,ADCY8,AKAP12,CNGB1,DHH,ENPP1,EYA1,FLNC,GNG4,GUCY1A1,H1-1,LIPE,MYH4,MYL3,MYLK,NGFR,PALM2AKAP2,PDE1A,PDE1B,PDE2A,PHKG1,PLCL1,PLN,PPP1R14A,PTPRD,PTPRT,TGFB3,TNNI3/Role of JAK2 in Hormone-like Cytokine Signaling$IGF1,LALBA,LEP,NPY,PROK1,SOCS2,VEGFDEndothelin-1 SignalingeADCY1,ADCY5,ADCY8,EDNRA,EDNRB,GUCY1A1,GUCY1A2,NPR1,PLA2G2C,PLA2G4D,PLA2G5,PLAAT5,PLCL1,PLD5,RASD1,SHENetrin Signaling:CACNA1C,CACNA1G,CACNA1H,CACNA2D2,CACNG5,CACNG8,PRKG1,UNC5C'Clathrin-mediated Endocytosis Signaling\ACTA1,ACTA2,ACTG2,AMPH,APOA2,APOD,APOF,F2R,FGF1,FGF10,FGF7,IGF1,ORM1,ORM2,PROK1,SH3GL2,VEGFDIRole of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid ArthritisfBMP8A,CALCR,COL1A1,CTSK,DKK3,FRZB,IGF1,IL1A,IL1R2,IL33,IL36G,LRP1,NGFR,RUNX2,SFRP2,SFRP4,TNFSF11,WNT9BBupropion DegradationCYP1A1,CYP2C18,CYP2F1,CYP4B14Regulation of Cellular Mechanics by Calpain Protease7CAPN11,CAPN3,CAPN8,CCNA1,CNGB1,ITGA1,ITGA11,ITGA8,RASD1 Adrenomedullin signaling pathway[ADCY1,ADCY5,ADCY8,GAD1,GAST,GUCY1A1,GUCY1A2,IL1A,IL33,IL36G,MYLK,NPR1,PLCL1,PRKG1,RASD1,SHEComplement SystemC4BPA,C6,C7,CFB,MASP1#Aryl Hydrocarbon Receptor SignalingMALDH1A3,CCNA1,CYP1A1,CYP2C18,ESR1,GSTA2,GSTM5,HSPB7,IL1A,NR2F1,TFF1,TGFB3,TYRTight Junction SignalingUACTA1,ACTA2,ACTG2,CLDN18,CLDN5,CLDN6,F2RL2,MYH11,MYH13,MYH4,MYH8,MYL3,MYLK,NGFR,TGFB3$Trehalose Degradation II (Trehalase) HKDC1,TREHGlycine Cleavage Complex GLDC,OCA2$Multiple Sclerosis Signaling PathwayaC6,C7,CAPN11,CAPN3,CAPN8,GRIN2C,IL12A,IL17B,IL1A,IL33,IL36G,LEP,MASP1,SLC8A2,TGFB3,TNFSF11,TNFSF9eNOS SignalingQADCY1,ADCY5,ADCY8,CCNA1,CHRNA9,CNGB1,ESR1,GUCY1A1,GUCY1A2,LPAR4,PRKG1,PROK1,VEGFDOpioid Signaling PathwayADCY1,ADCY5,ADCY8,BLK,CACNA1C,CACNA1G,CACNA1H,CACNA2D2,CACNG5,CACNG8,GNG4,GRIN2C,GUCY1A1,PDE1A,PDE1B,PENK,RASD1,RGS5,RGS8,SCN7A,SLC12A5+Dopamine-DARPP32 Feedback in cAMP SignalingiADCY1,ADCY5,ADCY8,CACNA1C,CACNA2D2,CACNG5,CACNG8,GRIN2C,GUCY1A1,GUCY1A2,KCNJ12,KCNJ8,PLCL1,PPP1R14A,PRKG1 Synaptogenesis Signaling PathwayADCY1,ADCY5,ADCY8,CACNA2D2,CDH11,CDH12,EFNA2,GRIA1,GRIA2,GRIA3,GRIN2C,GUCY1A1,LRP1,MAPT,NRXN2,RASD1,RASGRP2,SHE,SYT10,SYT16,SYT9,THBS2,THBS4VDR/RXR Activation6CALB1,CXCL10,HSD17B2,IGFBP1,IGFBP5,IL12A,RUNX2,TNFSF11Relaxin SignalingMADCY1,ADCY5,ADCY8,ENPP1,GAD1,GAST,GNG4,GUCY1A1,GUCY1A2,NPR1,PDE1A,PDE1B,PDE2ALXR/RXR Activation9AMBP,APOA2,APOD,APOF,IL1A,IL1R2,IL33,IL36G,NGFR,ORM1,ORM2#Insulin Secretion Signaling PathwayADCY1,ADCY5,ADCY8,ASIC2,CACNA1C,CACNA1G,CACNA1H,CACNA2D2,CACNG5,CACNG8,CCKAR,CPE,CSH1/CSH2,GUCY1A1,KCNB1,KCNJ8,PCSK1,PLCL1,SCNN1A,SCNN1B#Role of NFAT in Cardiac HypertrophyqADCY1,ADCY5,ADCY8,CACNA1C,CACNA1G,CACNA1H,CACNA2D2,CACNG5,CACNG8,GATA4,GNG4,GUCY1A1,IGF1,PLCL1,RASD1,SLC8A2,TGFB3Histamine BiosynthesisHDC4-hydroxybenzoate BiosynthesisTAT$4-hydroxyphenylpyruvate BiosynthesisCardiac Hypertrophy SignalingwADCY1,ADCY5,ADCY8,ADRA2A,ADRB1,ADRB3,CA< CNA1C,CACNA2D2,CACNG5,CACNG8,GATA4,GNG4,GUCY1A1,IGF1,MYL3,PLCL1,RASD1,RND1,TGFB3!Leukocyte Extravasation Signaling]ACTA1,ACTA2,ACTG2,ARHGAP6,CLDN18,CLDN5,CLDN6,CTNNA2,CXCL12,DLC1,EDIL3,MMP10,MMP11,MMP16,TIMP3,Agrin Interactions at Neuromuscular Junction(ACTA1,ACTA2,ACTG2,ERBB4,LAMA2,NRG3,RASD1Actin Cytoskeleton SignalingbACTA1,ACTA2,ACTG2,F2R,FGF1,FGF10,FGF7,FN1,ITGA1,ITGA11,ITGA8,MYH11,MYH13,MYH4,MYH8,MYL3,MYLK,RASD1Estrogen Biosynthesis$CYP1A1,CYP2C18,CYP2F1,CYP4B1,HSD17B2!Oxidative Ethanol Degradation IIIALDH1A3,CYP2C18,CYP2F1,CYP2W1#Oxytocin In Brain Signaling PathwayjCACNA1C,CACNA1G,CACNA1H,CACNA2D2,CACNG5,CACNG8,GNG4,NLRP4,OXTR,PLA2G2C,PLA2G4D,PLA2G5,PLAAT5,RASD1,SLC12A5 ILK SignalingTACTA1,ACTA2,ACTG2,FLNC,FN1,LIMS2,MYH11,MYH13,MYH4,MYH8,MYL3,PROK1,RND1,TGFB1I1,VEGFD-IL-12 Signaling and Production in MacrophageslADRA2A,APOA2,APOD,APOF,COL10A1,COL18A1,COL1A1,COL1A2,COL2A1,COL3A1,COL5A3,IL12A,ORM1,ORM2,SELP,TGFB3,TNFSF11/Neutrophil Extracellular Trap Signaling PathwayBLK,COL10A1,COL11A1,COL12A1,COL18A1,COL1A1,COL1A2,COL24A1,COL2A1,COL3A1,COL4A6,COL5A1,COL5A2,COL5A3,COL6A3,COL9A3,CTSG,ELANE,MT-ND1,NOX4,PLA2G2C,PLA2G4D,PLA2G5,PLAAT5,PLCL1,SELP!Sphingosine-1-phosphate Signaling>ADCY1,ADCY5,ADCY8,GUCY1A1,PDGFRA,PDGFRB,PLCL1,RND1,S1PR1,SMPD3#Pulmonary Healing Signaling PathwayUBLK,CXCL12,DLK1,ELANE,FGF10,FGF7,MMP10,MMP11,MMP16,NGFR,PROK1,RASD1,TGFB3,VEGFD,WNT9BnNOS Signaling in NeuronsCAPN11,CAPN3,CAPN8,GRIN2C,RASD1 STAT3 Pathway?HGF,IGF1,IL1A,IL1R2,IL20RB,NGFR,NTRK1,PDGFRA,PDGFRB,RASD1,SOCS2PPAR Signaling4IL1A,IL1R2,IL33,IL36G,NGFR,NR2F1,PDGFRA,PDGFRB,RASD11Antiproliferative Role of Somatostatin Receptor 2)GAD1,GAST,GNG4,GUCY1A1,GUCY1A2,NPR1,RASD1Acute Phase Response SignalingIAMBP,APOA2,C4BPA,CFB,FN1,IL1A,IL33,IL36G,ITIH3,NGFR,ORM1,ORM2,RASD1,SOCS2'Caveolar-mediated Endocytosis Signaling)ACTA1,ACTA2,ACTG2,FLNC,ITGA1,ITGA11,ITGA8Leptin Signaling in Obesity'ADCY1,ADCY5,ADCY8,GUCY1A1,LEP,NPY,PLCL1,Sertoli Cell-Sertoli Cell Junction Signaling`ACTA1,ACTA2,ACTG2,CLDN18,CLDN5,CLDN6,CTNNA2,GUCY1A1,GUCY1A2,ITGA1,ITGA11,ITGA8,PRKG1,RASD1,TGFB3Retinoate Biosynthesis IADH1C,ADH7,ALDH1A3,RDH10-Adrenergic Signaling8ADCY1,ADCY5,ADCY8,ADRA2A,GNG4,GUCY1A1,PHKG1,RASD1,SLC8A2The Visual CycleLRAT,RDH10,RPE659Embryonic Stem Cell Differentiation into Cardiac Lineages GATA4,ISL1GDP-glucose Biosynthesis HKDC1,PGM5FXR/RXR Activation6AMBP,APOA2,APOD,APOF,IL1A,IL33,IL36G,ORM1,ORM2,SLCO1B3(Acetone Degradation I (to Methylglyoxal))Regulation of Actin-based Motility by Rho3ACTA1,ACTA2,ACTG2,ITGA1,ITGA11,ITGA8,MYL3,MYLK,RND1L-dopachrome BiosynthesisTYRThyroid Hormone BiosynthesisTPO#Glutamate Dependent Acid ResistanceGAD1Phospholipases(PLA2G2C,PLA2G4D,PLA2G5,PLAAT5,PLCL1,PLD5MRegulation Of The Epithelial Mesenchymal Transition By Growth Factors PathwayRCDH12,FGF1,FGF10,FGF7,HGF,HMGA2,NGFR,PDGFRA,PDGFRB,RASD1,TGFB3,TNFSF11,TNFSF9,ZEB1HMGB1 SignalingDIL12A,IL17B,IL1A,IL33,IL36G,LEP,NGFR,RASD1,RND1,TGFB3,TNFSF11,TNFSF9+Glucose and Glucose-1-phosphate Degradation+Apelin Cardiac Fibroblast Signaling PathwayAPLNR,CCN2,TGFB3Synaptic Long Term PotentiationAADCY1,ADCY8,CACNA1C,GRIA1,GRIA2,GRIA3,GRIN2C,PLCL1,PPP1R14A,RASD1IL-17 SignalingLCXCL5,IL12A,IL17B,IL1A,IL33,IL36G,LEP,PROK1,RASD1,TGFB3,TNFSF11,TNFSF9,VEGFD:Transcriptional Regulatory Network in Embryonic Stem Cells@CALB1,ESX1,FOXD3,GATA4,IGF1,IGF2,ISL1,NOG,PAX6,RASD1,TGFB3,WNT9BCDK5 Signaling8ADCY1,ADCY5,ADCY8,GUCY1A1,LAMA2,MAPT,NGFR,PPP1R14A,RASD1Bladder Cancer Signaling3FGF1,FGF10,FGF7,MMP10,MMP11,MMP16,PROK1,RASD1,VEGFDARole of Cytokines in Mediating Communication between Immune CellsIL12A,IL1A,IL20,IL33,IL36G"Apelin Adipocyte Signaling Pathway)ADCY1,ADCY5,ADCY8,APLNR,GUCY1A1,LIPE,NOX4,LPS/IL-1 Mediated Inhibition of RXR Function\ACOX2,ALDH1A3,CYP2C18,CYP2F1,FABP4,FABP7,FMO1,GSTA2,GSTM5,IL1A,IL1R2,IL33,IL36G,NGFR,SLCO1B3!Methionine Salvage II (Mammalian)BHMTp38 MAPK Signaling5HSPB7,IL1A,IL1R2,IL33,IL36G,MAPT,PLA2G4D,PLA2G5,TGFB3Estrogen Receptor SignalingADCY1,ADCY5,ADCY8,CACNA1C,CACNA2D2,CACNG5,CACNG8,ESR1,GNG4,GUCY1A1,IGF1,IGF2,LEP,MMP10,MMP11,MMP16,MT-ND1,MYL3,PGR,PLCL1,PROK1,RASD1,RUNX2,SHE,VEGFDDHCR24 Signaling Pathway3AMBP,APOA2,APOD,APOF,ESR1,IGF1,MAPT,ORM1,ORM2,RASD1(Mechanisms of Viral Exit from Host CellsACTA1,ACTA2,ACTG2,SH3GL2Role of IL-17A in Psoriasis CXCL5,CXCL6RHOA Signaling3ACTA1,ACTA2,ACTG2,ARHGAP6,DLC1,IGF1,LPAR4,MYL3,MYLKBMP signaling pathway'BMP8A,CHRD,GREM1,NOG,RASD1,RUNX2,ZNF423Triacylglycerol DegradationCES1,LIPE,LIPF,RPE65Ethanol Degradation IIADH1C,ADH7,ALDH1A3NRole of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid ArthritisrCXCL12,DKK3,FN1,FRZB,IL1A,IL1R2,IL33,IL36G,LRP1,NGFR,PLCL1,PROK1,PRSS1,PRSS3,RASD1,SFRP2,SFRP4,TNFSF11,VEGFD,WNT9B-CDX Gastrointestinal Cancer Signaling PathwayIBMP8A,CA1,IL12A,IL17B,IL1A,IL33,IL36G,LEP,NOX4,TGFB3,TNFSF11,TNFSF9,WNT9B tRNA SplicingENPP1,PDE1A,PDE1B,PDE2APhenylethylamine Degradation IAOC3Eumelanin BiosynthesisTaurine BiosynthesisFMO1Lactose Degradation IIIGLB1L3(Noradrenaline and Adrenaline Degradation(Extrinsic Prothrombin Activation PathwayF12,F5#Neuroinflammation Signaling PathwayvCALB1,CX3CR1,CXCL10,CXCL12,GABRA5,GABRE,GAD1,GJB1,GRIA1,GRIN2C,IL12A,KLK3,MAPT,NOX4,PLA2G4D,PLA2G5,SLC1A2,SLC6A1,TGFB3G Beta Gamma Signaling?ADCY1,CACNA1C,CACNA1G,CACNA1H,CACNA2D2,CACNG5,CACNG8,GNG4,RASD17Role of IL-17F in Allergic Inflammatory Airway DiseasesCXCL10,CXCL5,CXCL6,IGF1ID1 Signaling PathwayHBHLHE22,BLK,CCN2,CHRNA9,FN1,GLI2,IGF2,KLF17,NGFR,PROK1,RASD1,TGFB3,VEGFDSonic Hedgehog SignalingCCNB3,GLI2,GLIS1+Xenobiotic Metabolism AHR Signaling Pathway%ABCG2,ALDH1A3,CYP1A1,GSTA2,GSTM5,IL1AThrombin SignalingRADCY1,ADCY5,ADCY8,ARHGEF15,F2R,F2RL2,GATA4,GNG4,GUCY1A1,MYL3,MYLK,PLCL1,RASD1,RND1KRole of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza"CXCL10,IL12A,IL1A,IL33,IL36G,S1PR1.Factors Promoting Cardiogenesis in Vertebrates5BMP8A,CER1,GATA4,LRP1,NOG,NOX4,PLCL1,TBX5,TGFB3,WNT9B"Inhibition of Angiogenesis by TSP1GUCY1A1,GUCY1A2,HSPG21Melanocyte Development and Pigmentation Signaling(ADCY1,ADCY5,ADCY8,GUCY1A1,PAX3,RASD1,TYR7Role of MAPK Signaling in the Pathogenesis of Influenza*CXCL10,PLA2G2C,PLA2G4D,PLA2G5,PLAAT5,RASD1 Erythropoietin Signaling Pathway?HBQ1,IL12A,IL17B,IL1A,IL33,IL36G,LEP,RASD1,TGFB3,TNFSF11,TNFSF9Creatine-phosphate Biosynthesis CKMT1A/CKMT1B/Glutamate Degradation III (via 4-aminobutyrate)GNRH SignalingSADCY1,ADCY5,ADCY8,CACNA1C,CACNA1G,CACNA1H,CACNA2D2,CACNG5,CACNG8,GNG4,GUCY1A1,RASD1 PAK Signaling0ITGA1,ITGA11,ITGA8,MYL3,MYLK,PDGFRA,PDGFRB,RASD1+Remodeling of Epithelial Adherens JunctionsACTA1,ACTA2,ACTG2,CTNNA2,HGFAmyloid ProcessingCAPN11,CAPN3,CAPN8,MAPTTR/RXR Activation!ADRB1,COL6A3,DIO2,DIO3,PCK1,THRSP&Colorectal Cancer Metastasis Signaling_ADCY1,ADCY5,ADCY8,GNG4,GUCY1A1,LRP1,MMP10,MMP11,MMP16,PROK1,PTGER3,RASD1,RND1,TGFB3,VEGFD,WNT9BMyelination Signaling PathwaykARHGAP6,BLK,BMP8A,CNTN6,DLC1,ERBB4,GLI2,GLIS1,HES5,IGF1,KLK3,LAMA2,LAMA4,MPZ,NGFR,PDGFRA,PDGFRB,RASD1,WNT9BCoagulation System F12,F2R,F5%Chondroitin and Dermatan BiosynthesisCHSY3@Tryptophan Degradation to 2-amino-3-carboxymuconate SemialdehydeIDO1IGF-1 Signaling*CCN2,IGF1,IGFBP1,IGFBP4,IGFBP5,RASD1,SOCS2Phototransduction PathwayCNGB1,GUCY1A1,GUCY1A2,NPR1Paxillin Signaling*ACTA1,ACTA2,ACTG2,ITGA1,ITGA11,ITGA8,RASD1)Endocannabinoid Developing Neuron Pathway/ADCY1,ADCY5,ADCY8,GNG4,GUCY1A1,PAX6,RASD1,STMN2Ephrin Receptor SignalingKARHGEF15,CXCL12,EFNA2,FGF1,GNG4,GRIN2C,ITGA1,ITGA11,ITGA8,PROK1,RASD1,VEGFDAspartate Degradation IILIPFPPAR/RXR ActivationEADCY1,ADCY5,ADCY8,APOA2,CYP2C18,GUCY1A1,IL1R2,NR2F1,PLCL1,RASD1,TGFB3LRole of Pattern Recognition Receptors in Recognition of Bacteria and Viruses4IL12A,IL17B,IL1A,IL33,IL36G,LEP,TGFB3,TNFSF11,TNFSF9IL-6 Signaling-COL1A1,HSPB7,IL1A,IL1R2,IL33,IL36G,NGFR,RA< SD1bDifferential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F IL12A,IL1A6Pyrimidine Deoxyribonucleotides De Novo Biosynthesis IAK5,PCK1Integrin SignalingGACTA1,ACTA2,ACTG2,CAPN11,CAPN3,CAPN8,ITGA1,ITGA11,ITGA8,MYLK,RASD1,RND1BRole of MAPK Signaling in Inhibiting the Pathogenesis of Influenza$CXCL10,PLA2G2C,PLA2G4D,PLA2G5,PLAAT5(P2Y Purigenic Receptor Signaling Pathway1ADCY1,ADCY5,ADCY8,GNG4,GUCY1A1,P2RY12,PLCL1,RASD1Histidine Degradation IIIAMDHD1Sphingomyelin MetabolismSMPD3#Type II Diabetes Mellitus Signaling?CACNA1C,CACNA1G,CACNA1H,CACNA2D2,CACNG5,CACNG8,NGFR,SMPD3,SOCS2PTEN Signaling7ITGA1,ITGA11,ITGA8,NGFR,NTRK1,PDGFRA,PDGFRB,PREX2,RASD1:Role of JAK family kinases in IL-6-type Cytokine Signaling$PROK1,SERPINA12,SERPINA9,TGFB3,VEGFDSignaling by Rho Family GTPasesVACTA1,ACTA2,ACTG2,ARHGEF15,CDH11,CDH12,DES,GNG4,ITGA1,ITGA11,ITGA8,MYL3,MYLK,NOX4,RND1IL-1 Signaling#ADCY1,ADCY5,ADCY8,GNG4,GUCY1A1,IL1AWNT/-catenin Signaling8CDH12,DKK3,FRZB,LRP1,SFRP2,SFRP4,SOX17,SOX21,TGFB3,WNT9BIL-13 Signaling Pathway$AGR2,ANO1,BLK,CXCL6,IL33,POSTN,TGFB3Neuregulin Signaling'DCN,ERBB4,ITGA1,ITGA11,ITGA8,NRG3,RASD1VEGF Signaling#ACTA1,ACTA2,ACTG2,PROK1,RASD1,VEGFD'Tryptophan Degradation III (Eukaryotic)CA1,IDO1Dopamine Receptor Signaling"ADCY1,ADCY5,ADCY8,GUCY1A1,PPP1R14ASPINK1 General Cancer PathwayMT1H,PRSS1,PRSS3,RASD1&Apelin Cardiomyocyte Signaling Pathway APLNR,MYL3,MYLK,PLCL1,PLN,SLC8A2;Regulation of the Epithelial-Mesenchymal Transition Pathway=CDH12,FGF1,FGF10,FGF7,HGF,HMGA2,PDGFRB,RASD1,TGFB3,WNT9B,ZEB1"Pathogenesis of Multiple SclerosisCXCL103Salvage Pathways of Pyrimidine DeoxyribonucleotidesAICDAEstrogen-mediated S-phase Entry CCNA1,ESR1#Glutathione-mediated Detoxification GSTA2,GSTM51Neuropathic Pain Signaling In Dorsal Horn Neurons#GRIA1,GRIA2,GRIA3,GRIN2C,PLCL1,TAC1IL-4 SignalingANO1,COL10A1,COL11A1,COL12A1,COL18A1,COL1A1,COL1A2,COL24A1,COL2A1,COL3A1,COL4A6,COL5A1,COL5A2,COL5A3,COL6A3,COL9A3,FCER2,RASD1,TGFB3,TIMP3$Apelin Endothelial Signaling Pathway.ADCY1,ADCY5,ADCY8,APLNR,GNG4,GUCY1A1,RASD1,TEK)MSP-RON Signaling In Cancer Cells Pathway+ACTA2,F12,KLK14,KLK2,KLK3,PROK1,RASD1,VEGFDIL-15 Production&BLK,ERBB4,NTRK1,PDGFRA,PDGFRB,ROS1,TEK&Human Embryonic Stem Cell PluripotencyABMP8A,FOXD3,KLK3,LEFTY2,NOG,NTRK1,PDGFRA,PDGFRB,RASD1,TGFB3,WNT9BProstanoid BiosynthesisPTGDS Oleate Biosynthesis II (Animals)PTPRTGlycine Betaine Degradation1Macrophage Classical Activation Signaling Pathway;CXCL10,IL12A,IL17B,IL1A,IL33,IL36G,LEP,TGFB3,TNFSF11,TNFSF9(VEGF Family Ligand-Receptor InteractionsNRP1,PLA2G4D,PLA2G5,RASD1,VEGFDRole of Tissue Factor in Cancer7BLK,CCN2,F2R,FLNC,HGF,NGFR,PRSS1,PRSS3,RASD1,TGFB3,ZEB1%NAD biosynthesis II (from tryptophan)Glycogen Degradation IIPGM5CXCR4 Signaling5ADCY1,ADCY5,ADCY8,CXCL12,GNG4,GUCY1A1,MYL3,RASD1,RND1Androgen SignalingACACNA1C,CACNA1G,CACNA1H,CACNA2D2,CACNG5,CACNG8,GNG4,TAF4B,TGFB1I1 MYC Mediated Apoptosis SignalingADRB1,ADRB3,NGFR,UDP-N-acetyl-D-galactosamine Biosynthesis IIHKDC1Antioxidant Action of Vitamin CBasal Cell Carcinoma SignalingBMP8A,GLI2,GLIS1,WNT9BARole of MAPK Signaling in Promoting the Pathogenesis of Influenza,ATP6V0D2,PLA2G2C,PLA2G4D,PLA2G5,PLAAT5,RASD1Growth Hormone SignalingCSH1/CSH2,IGF1,IGF2,SOCS2Glioma Invasiveness SignalingF2R,RASD1,RND1,TIMP3Granzyme A SignalingF2R,FN1,H1-1,MT-ND1$Actin Nucleation by ARP-WASP ComplexITGA1,ITGA11,ITGA8,RASD1,RND1'NRF2-mediated Oxidative Stress ResponseDACTA1,ACTA2,ACTG2,CYP1A1,CYP2C18,CYP2F1,FMO1,FOSL1,GSTA2,GSTM5,RASD1"Iron homeostasis signaling pathway.ATP6V0D2,BMP8A,HBQ1,LRP1,PDGFRA,PDGFRB,SLC40A1Glycogen Degradation III'Bile Acid Biosynthesis, Neutral PathwayAKR1D1Histamine DegradationALDH1A3+Xenobiotic Metabolism CAR Signaling Pathway?ALDH1A3,CYP1A1,FMO1,GSTA2,GSTM5,UGT2B11,UGT2B15,UGT2B17,UGT2B28G12/13 Signaling&CDH11,CDH12,F2R,F2RL2,LPAR4,MYL3,RASD1)Chondroitin Sulfate Degradation (Metazoa)CEMIPCholine Biosynthesis IIIPLD5NOD1/2 Signaling Pathway+Xenobiotic Metabolism PXR Signaling PathwayAALDH1A3,CES1,GSTA2,GSTM5,PPP1R14A,UGT2B11,UGT2B15,UGT2B17,UGT2B28(MSP-RON Signaling In Macrophages PathwayF12,IL12A,KLK14,KLK2,KLK3,RASD1CSDE1 Signaling Pathway FABP7,FN1,TNCAdipogenesis pathway'DLK1,EBF1,FABP4,FGF1,LEP,RUNX1T1,ZNF423Angiopoietin SignalingANGPT4,ANGPTL1,RASD1,TEK*Cholecystokinin/Gastrin-mediated SignalingGAST,IL1A,IL33,IL36G,RASD1,RND1/Xenobiotic Metabolism General Signaling Pathway1GSTA2,GSTM5,RASD1,UGT2B11,UGT2B15,UGT2B17,UGT2B28Androgen BiosynthesisSRD5A2Leukotriene BiosynthesisDPEP1&Dermatan Sulfate Degradation (Metazoa)Thyroid Cancer SignalingIGF1,KLK3,NTRK1,RASD1Toll-like Receptor SignalingIL12A,IL1A,IL33,IL36GHOTAIR Regulatory Pathway1COL1A1,COL1A2,COL3A1,ESR1,MMP10,MMP11,MMP16,WNT9B&MIF-mediated Glucocorticoid RegulationPLA2G4D,PLA2G5Neurotrophin/TRK SignalingKLK3,NGFR,NTRK1,RASD1*Pyrimidine Ribonucleotides InterconversionFatty Acid -oxidationParkinson's SignalingUCHL1WNK Renal Signaling Pathway ASIC2,IGF1,SCNN1A,SCNN1B,SLC12A5*Estrogen-Dependent Breast Cancer SignalingESR1,HSD17B2,IGF1,RASD1Putrescine Degradation III/Pyrimidine Ribonucleotides De Novo BiosynthesiseDifferential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17FIL12AGlutaryl-CoA DegradationCA1Histidine Degradation VI4Tryptophan Degradation X (Mammalian, via Tryptamine)Ethanol Degradation IVNAD Signaling PathwayH1-1,HGF,IGF1,NKX2-1,PRDM13Pyroptosis Signaling PathwayGBP5,IL1A,NGFR,NLRP4CLEAR Signaling Pathway8ATP6V0D2,HGF,IGF1,NGFR,NTRK1,PDGFRA,PDGFRB,RASD1,TNFSF11(Immunogenic Cell Death Signaling PathwayCXCL10,LRP1,NGFR%MicroRNA Biogenesis Signaling PathwayESR1,HGF,HOPX,IGF1,RASD1,TGFB3*Ribonucleotide Reductase Signaling PathwayESR1,HGF!Glucocorticoid Receptor SignalingDNALI1,ESR1,IGF1,IL1A,IL1R2,IL20RB,KRT13,KRT16,KRT222,KRT37,KRT6A,KRT79,MT-ND1,PCK1,PDK4,PGR,PLA2G4D,PLA2G5,RASD1,TAF4B,TAT,TGFB3Natural Killer Cell Signaling>COL10A1,COL18A1,COL1A1,COL1A2,COL2A1,COL3A1,COL5A3,IL12A,RASD1IL-10 SignalingCCN4,IL1A,IL1R2,IL33,IL36G3Macrophage Alternative Activation Signaling Pathway-FCER2,IL12A,IL1A,IL1R2,IL33,IL36G,MARCO,TGFB3Fc Epsilon RI SignalingMS4A2,PLA2G4D,PLA2G5,RASD1Huntington's Disease Signaling'CAPN11,CAPN3,CAPN8,GNG4,IGF1,NTRK1,PENK.Chaperone Mediated Autophagy Signaling PathwaycATP6V0D2,MAPT,MMP10,MMP11,MMP16,MTRNR2L1,MTRNR2L10,MTRNR2L12,MTRNR2L13,MTRNR2L3,MTRNR2L6,PAX2,UCHL1IL-33 Signaling PathwayCMA1,CTSG,ELANE,IL1A,IL33,IL36G p53 SignalingADGRB1Mitochondrial DysfunctionaADRB3,ATP1A2,CACNA1C,CACNA1G,CACNA1H,CACNA2D2,CACNG5,CACNG8,CAPN11,CAPN3,CAPN8,COX7A1,MAPT,MT-ND1Ceramide SignalingNGFR,RASD1,S1PR1,SMPD3PXR/RXR ActivationGSTA2,IGFBP1,SLCO1B314-3-3-mediated SignalingMAPT,PLCL1,RASD1?Fc Receptor-mediated Phagocytosis in Macrophages and MonocytesACTA1,ACTA2,ACTG2,PLD5IL-8 Signaling)GNG4,NOX4,PLD5,PROK1,RASD1,RND1,TEK,VEGFD:Role of PKR in Interferon Induction and Antiviral ResponseMARCO,NLRP4,PDGFRB,SCARA5TREM1 SignalingNLRP4!MIF Regulation of Innate Immunity1Role of NFAT in Regulation of the Immune ResponseGATA4,GNG4,MS4A2,RASD1"FcRIIB Signaling in B Lymphocytes4CACNA1C,CACNA1G,CACNA1H,CACNA2D2,CACNG5,CACNG8,RASD1LPS-stimulated MAPK SignalingRASD1NF-B Activation by VirusesCCR5 Signaling in Macrophages3CACNA1C,CACNA1G,CACNA1H,CACNA2D2,CACNG5,CACNG8,GNG4CD40 SignalingFCER2IL-3 SignalingfMLP Signaling in NeutrophilsGNG4,NOX4,RASD1 4-1BB Signaling in T LymphocytesTNFSF9Thrombopoietin Signaling*CTLA4 Signaling in Cytotoxic T LymphocytesBLK,IDO1,PLD5,RASD1,TGFB3< Induction of Apoptosis by HIV1NGFRT Helper Cell Differentiation IL12A,NGFRIL-9 SignalingSOCS2CCR3 Signaling in EosinophilsGNG4,MYLK,PLA2G4D,PLA2G5,RASD1Oncostatin M Signaling RASD1,TIMP3IL-15 Signaling"Virus Entry via Endocytic PathwaysACTA1,ACTA2,ACTG2,FLNC,RASD1Dendritic Cell Maturation\CD1A,COL10A1,COL18A1,COL1A1,COL1A2,COL2A1,COL3A1,COL5A3,IL12A,IL1A,IL33,IL36G,LEP,NGFR,PLCL1Reelin Signaling in Neurons$ARHGEF15,BLK,DNALI1,GRIN2C,MAPT,PDK4HIF1 Signaling6HGF,IGF1,IGF2,MMP10,MMP11,MMP16,NOX4,PROK1,RASD1,VEGFDMelatonin SignalingPLCL1CNTF Signaling/Cardiomyocyte Differentiation via BMP ReceptorsGATA4Renin-Angiotensin Signaling#ADCY1,ADCY5,ADCY8,GUCY1A1,RASD1,SHE$Docosahexaenoic Acid (DHA) SignalingBCL2A1Semaphorin Signaling in Neurons NRP1,RND1Molecular Mechanisms of CancermADCY1,ADCY5,ADCY8,ARHGEF15,BMP8A,CDK15,CTNNA2,DHH,GNG4,GUCY1A1,ITGA1,ITGA11,ITGA8,LRP1,RASD1,RND1,TGFB3,WNT9B!Lipid Antigen Presentation by CD1CD1A!Mitotic Roles of Polo-Like KinaseCCNB3 HGF SignalingHGF,ITGA1,ITGA11,ITGA8,RASD10FLT3 Signaling in Hematopoietic Progenitor Cells8DNA Methylation and Transcriptional Repression SignalingAICDA,CDK15,ZEB1 ATM Signaling CCNB3,ZEB1:Role of OCT4 in Mammalian Embryonic Stem Cell Pluripotency FOXD3,NR2F1)Germ Cell-Sertoli Cell Junction Signaling)ACTA1,ACTA2,ACTG2,CTNNA2,RASD1,RND1,TGFB3)Aldosterone Signaling in Epithelial Cells4ASIC2,HSPA12B,HSPB7,KCNJ8,KCNMA1,PLCL1,SCNN1A,SCNN1B;Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency#BMP8A,FOXD3,GATA4,RASD1,TCL1A,WNT9BProlactin SignalingKCNJ8,KCNMA1,RASD1,SOCS2Melanoma SignalingProstate Cancer Signaling KLK3,RASD1Renal Cell Carcinoma Signaling HGF,RASD1"Type I Diabetes Mellitus SignalingCPE,GAD1,IL12A,NGFR,SOCS2Endometrial Cancer Signaling CTNNA2,RASD1"Primary Immunodeficiency SignalingGlioma SignalingIGF1,IGF2,PDGFRA,PDGFRB,RASD1$Autoimmune Thyroid Disease Signaling Acute Myeloid Leukemia Signaling CCNA1,RASD1#Graft-versus-Host Disease SignalingIL1A,IL33,IL36G"Chronic Myeloid Leukemia Signaling2BLK,GLI2,GLIS1,LIN28B,PAX5,PLCL1,RASD1,TGFB3,WNT9B$Non-Small Cell Lung Cancer SignalingEProduction of Nitric Oxide and Reactive Oxygen Species in Macrophages,APOA2,APOD,APOF,NGFR,ORM1,ORM2,PPP1R14A,RND1p70S6K SignalingF2R,F2RL2,MAPT,PLCL1,RASD1ERK5 SignalingFOSL1,NTRK1,RASD1mTOR SignalingPLD5,PROK1,RASD1,RND1,VEGFD#Pancreatic Adenocarcinoma SignalingPLD5,PROK1,TGFB3,VEGFD%G Protein Signaling Mediated by TubbyGNG46Communication between Innate and Adaptive Immune CellsCXCL10,IL12A,IL1A,IL33,IL36G:Crosstalk between Dendritic Cells and Natural Killer CellsACTA1,ACTA2,ACTG2,IL12A&Systemic Lupus Erythematosus Signaling C6,C7,CD22,IL1A,IL33,IL36G,RASD1CDC42 SignalingITGA1,ITGA11,ITGA8,MYL3,MYLKEIF2 SignalingACTA1,ACTA2,ACTG2,NOX4,RASD1AMPK Signaling+ADRA2A,ADRB1,ADRB3,AK5,CHRNA9,GNG4,LEP,LIPE"Hereditary Breast Cancer Signaling RAC SignalingITGA1,ITGA11,ITGA8,NOX4,RASD1Phospholipase C SignalinggADCY1,ADCY5,ADCY8,ARHGEF15,GNG4,GUCY1A1,ITGA1,ITGA11,ITGA8,MYL3,PLA2G4D,PLA2G5,PLD5,PPP1R14A,RASD1,RND1Ovarian Cancer SignalingEDNRA,PROK1,RASD1,VEGFD,WNT9B HER-2 Signaling in Breast CancerBLK,COX7A1,IL1A,MS4A2,PGR,RASD1;Altered T Cell and B Cell Signaling in Rheumatoid ArthritisIL12A,IL1A,IL33,IL36G,TNFSF11'Regulation of eIF4 and p70S6K SignalingITGA1,ITGA11,ITGA8,RASD1RANK Signaling in OsteoclastsTNFSF11!Glioblastoma Multiforme Signaling.IGF1,IGF2,PDGFRA,PDGFRB,PLCL1,RASD1,RND1,WNT9BDRegulation of IL-2 Expression in Activated and Anergic T Lymphocytes RASD1,TGFB3=Role of WNT/GSK-3 Signaling in the Pathogenesis of InfluenzaWNT9BPKC Signaling in T Lymphocytes1Antiproliferative Role of TOB in T Cell Signaling CCNA1,TGFB3PI3K Signaling in B LymphocytesBLK,PLCL1,RASD1!Cyclins and Cell Cycle RegulationCCNA1,CCNB3,MYT1,TGFB3-Cell Cycle Control of Chromosomal ReplicationCDK15%Assembly of RNA Polymerase II ComplexTAF4B IL-17A Signaling in Airway CellsRole of IL-17A in ArthritisIL-17A Signaling in FibroblastsCXCL5!IL-17A Signaling in Gastric Cells.Role of JAK1 and JAK3 in c Cytokine Signaling NGF SignalingNGFR,NTRK1,RASD1,SMPD3Telomerase Signaling&Mouse Embryonic Stem Cell Pluripotency FOXD3,RASD1)Hematopoiesis from Pluripotent Stem CellsEphrin A Signaling EFNA2,NGFREphrin B Signaling CXCL12,GNG4ERBB SignalingERBB4,NRG3,RASD1ERB2-ERBB3 Signaling NRG3,RASD1ERBB4 SignalingGADD45 SignalingTGFB3(GDNF Family Ligand-Receptor InteractionsGFRA1,GFRA3,RASD1Heparan Sulfate Biosynthesis LIPE,RPE65Dopamine Degradation*Heparan Sulfate Biosynthesis (Late Stages)%D-myo-inositol-5-phosphate Metabolism!ATP1A2,CILP,ENPP1,PPFIA2,PPP1R14A Chondroitin Sulfate BiosynthesisDermatan Sulfate Biosynthesis7D-myo-inositol (1,4,5,6)-Tetrakisphosphate Biosynthesis,Superpathway of Inositol Phosphate Compounds7D-myo-inositol (3,4,5,6)-tetrakisphosphate BiosynthesisTCA Cycle II (Eukaryotic)3-phosphoinositide Degradation(ATP1A2,CILP,ENPP1,INPP4B,PPFIA2,PPP1R14A3-phosphoinositide Biosynthesis.Salvage Pathways of Pyrimidine RibonucleotidesAICDA,AK5,PCK1Gluconeogenesis I.Chondroitin Sulfate Biosynthesis (Late Stages)&Superpathway of Methionine Degradation$DNA damage-induced 14-3-3 Signaling&Epithelial Adherens Junction SignalingCTNNA2,FGF1,HGF,MYH4,RASD1 Gq SignalingAVPR1A,CALCR,GNG4,PLD5,RND1PEDF Signaling RASD1,ZEB1TEC Kinase Signaling8ACTA1,ACTA2,ACTG2,BLK,GNG4,ITGA1,ITGA11,ITGA8,MS4A2,RND1UVA-Induced MAPK SignalingPLCL1,RASD1,SMPD3UVC-Induced MAPK Signaling RASD1,SMPD3Oxidative Phosphorylation COX7A1,MT-ND1HIPPO signaling FAT4,PPP1R14A"PCP (Planar Cell Polarity) PathwayWNT/Ca+ pathway&Cell Cycle: G1/S Checkpoint RegulationERK/MAPK Signaling;ESR1,HSPB7,ITGA1,ITGA11,ITGA8,PLA2G4D,PLA2G5,PPP1R14A,RASD1SAPK/JNK Signaling GNG4,RASD1PI3K/AKT Signaling%IL1R2,IL20RB,ITGA1,ITGA11,ITGA8,RASD1Protein Ubiquitination PathwayHSPA12B,HSPB7,UCHL1,USP44IL-2 Signaling FGF SignalingFGF1,FGF10,FGF7,HGFJAK/STAT SignalingGAST,RASD1,SOCS21Cell Cycle: G2/M DNA Damage Checkpoint Regulation CCNB3,CKS2Xenobiotic Metabolism SignalingOALDH1A3,CES1,CYP1A1,FMO1,GSTA2,GSTM5,IL1A,RASD1,UGT2B11,UGT2B15,UGT2B17,UGT2B28B Cell Receptor SignalingBCL2A1,CD22,EBF1,PAX5,RASD1Insulin Receptor Signaling'ASIC2,LIPE,PPP1R14A,RASD1,SCNN1A,SCNN1BChemokine Signaling CXCL12,RASD1Death Receptor SignalingACTA1,ACTA2,ACTG2,HSPB7TGF- SignalingRASD1,RUNX2,TGFB3,ZNF423Apoptosis SignalingBCL2A1,CAPN11,CAPN3,CAPN8,RASD1Notch SignalingHES5NF-B Signaling<IL1A,IL1R2,IL33,IL36G,NGFR,NTRK1,PDGFRA,PDGFRB,RASD1,TNFSF11T Cell Receptor SignalingPDGF SignalingPDGFRA,PDGFRB,RASD1Phagosome MaturationATP6V0D2,CTSG,CTSK,NOX4,TPO AutophagyHGF,IGF1,MAP1LC3C,NGFRMacropinocytosis Signaling(PD-1, PD-L1 cancer immunotherapy pathwayIL12A,NGFR,TGFB3%Cancer Drug Resistance By Drug Efflux ABCG2,RASD1Sumoylation Pathway RND1,ZEB1Th1 and Th2 Activation PathwayIL12A,IL33,S1PR1,TNFSF11 Th1 Pathway IL12A,TNFSF11 Th2 PathwayIL12A,IL33,S1PR1IL-7 Signaling Pathway EBF1,HGF,PAX5Sirtuin Signaling Pathway H1-1,MAP1LC3C,MT-ND1,PCK1,SCNN1ATh17 Activation Pathway)Endocannabinoid Cancer Inhibition Pathway+ADCY1,ADCY5,ADCY8,GUCY1A1,PROK1,SMPD3,VEGFD!Apelin Pancreas Signaling PathwayAPLNRApelin Muscle Signaling Pathway APLNR,GNG4BAG2 Signaling PathwayMAPTFAT10 Cancer Signaling Pathway NGFR,TGFB3PFKFB4 Signaling Pathway#T Cell Exhaustion Signaling Pathway IL12A,RASD1IL-23 Signaling Pathway8Systemic Lupus Erythematosus In T Cell Signaling PathwayESR1,LEP,RASD1,RND1<8Systemic Lupus Erythematosus In B Cell Signaling PathwayKCD22,IL12A,IL17B,IL1A,IL33,IL36G,LEP,RASD1,RASGRP2,SHE,TGFB3,TNFSF11,TNFSF9Senescence PathwaySCACNA1C,CACNA2D2,CACNG5,CACNG8,CAPN11,CAPN3,CAPN8,CCNB3,GATA4,IL1A,PDK4,RASD1,TGFB33Inhibition of ARE-Mediated mRNA Degradation PathwayNGFR,TNFSF11,TNFSF9BEX2 Signaling PathwayKLK3,NGFR,PROK1,VEGFDNecroptosis Signaling Pathway&CAPN11,CAPN3,CAPN8,NGFR,PLA2G4D,PLA2G5JRegulation Of The Epithelial Mesenchymal Transition In Development PathwayGLI2,GLIS1,WNT9B'Kinetochore Metaphase Signaling PathwayDNALI1,PPP1R14AGM-CSF Signaling BCL2A1,RASD1Ferroptosis Signaling PathwayANGPTL4,NOX4,RASD1Supplementary Table 7. 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