ࡱ> ON  T\pVelisage-10 B=K_8X@"1 Aptos Narrow1 Aptos Narrow1 Aptos Narrow1 Aptos Narrow1 Aptos Narrow1h6 Aptos Narrow1,6 Aptos Narrow16 Aptos Narrow16 Aptos Narrow1> Aptos Narrow14 Aptos Narrow14 Aptos Narrow1  Aptos Narrow1  Aptos Narrow1 Aptos Narrow1 Aptos Narrow1  Aptos Narrow1 Aptos Narrow1 Aptos Narrow1 Aptos Narrow1 Aptos Narrow1 Aptos Narrow1< Aptos Narrow1? Aptos Narrow1  Aptos Narrow1,8 Aptos Narrow18 Aptos Narrow18 Aptos Narrow1> Aptos Narrow14 Aptos Narrow1  Aptos Narrow1  Aptos Narrow1 Aptos Narrow"?"\ #,##0;"?"\ \-#,##0"?"\ #,##0;[Red]"?"\ \-#,##0 "?"\ #,##0.00;"?"\ \-#,##0.00%""?"\ #,##0.00;[Red]"?"\ \-#,##0.00;*8_ "?"\ * #,##0_ ;_ "?"\ * \-#,##0_ ;_ "?"\ * "-"_ ;_ @_ ,))_ * #,##0_ ;_ * \-#,##0_ ;_ * "-"_ ;_ @_ C,@_ "?"\ * #,##0.00_ ;_ "?"\ * \-#,##0.00_ ;_ "?"\ * "-"??_ ;_ @_ 4+1_ * #,##0.00_ ;_ * \-#,##0.00_ ;_ * "-"??_ ;_ @_ "?"#,##0;"?"\-#,##0"?"#,##0;[Red]"?"\-#,##0"?"#,##0.00;"?"\-#,##0.00!"?"#,##0.00;[Red]"?"\-#,##0.0052_ "?"* #,##0_ ;_ "?"* \-#,##0_ ;_ "?"* "-"_ ;_ @_ =:_ "?"* #,##0.00_ ;_ "?"* \-#,##0.00_ ;_ "?"* "-"??_ ;_ @_ \$#,##0_);\(\$#,##0\)\$#,##0_);[Red]\(\$#,##0\)\$#,##0.00_);\(\$#,##0.00\)# \$#,##0.00_);[Red]\(\$#,##0.00\)                                      A.I. + )      A~I~    }| @} @Y  b     A,I,          A.I.   i     20% - Accent2A" 20% - Accent2 % 20% - Accent6A2 20% - Accent6 % 20% - ?? 1w 20% - ?? 3w 20% - ?? 4w 20% - ?? 5w 40% - Accent3A' 40% - Accent3 % 40% - ?? 1w 40% - ?? 2w 40% - ?? 4w 40% - ?? 5%  40% - ?? 6%  60% - ?? 1%  60% - ?? 2%  60% - ?? 3%  60% - ?? 4%  60% - ?? 5% ! 60% - ?? 6w "Accent45)Accent4 %#Bad-Bad %$ Calculationi Calculation% % Comma&( Comma [0]'&Currency(. Currency [0])Good/Good a% *NeutralANeutral  W%3Normal % +OutputkOutput ???%????????? ???,$Percent-Title Title.Total1Total % /?? 1?? 0?? 2?? 1?? 3?? 2?? 4?? 3??????4?? 2 5?? 1?? 6?? 2?? 7?? 3?? 8?? 5?? 9?? 6?? :?????? ;??????<???? =??????83ffff̙3f3fff3f3f33333f33333 Table S10  T  u3Qox)z  dMbP?_*+%,[&ffffff?'ffffff?(?)?"[D S10333333?333333?U  ,? ,? , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,c@[Supplementary Table 10. The results of GO analysis (Molecular Function) in TARGET data set.?geneSet? description ?size?overlap?expect?enrichmentRatio?pValue ?FDR?userId GO:0019902phosphatase binding@f@&@G'9 @e8 @>>?%63~J?IASH2D4A;JAK3;TSC2;PPP1R18;PTPN1;CD22;SOD1;NFATC2;SPRED1;CDH2;PPME1 GO:0004896"cytokine receptor activityW@@&|p?Ň@y1XNY?~ ?2*IL27RA;IL2RB;IL1RAP;GPR35;EPOR;ACKR2;IL2RA GO:0046983%protein dimerization activityؓ@C@['c7@:?4i `?~ ?GZMA;HIST1H2AD;EXT1;MITF;HIST1H2BJ;SLC16A1;DRD2;ASGR1;PRDX4;SCARB1;DLK2;RCC1;SLC30A8;TSC2;ANO3;NOLC1;INHBA;H2AFZ;ADORA2A;TPST2;SOD1;ANO5;CDH2;CDH20;HIST2H2BF;POLE3;TENM1;MAD2L1;ADD1;ADCY2;CADM1;HIF3A;MGLL;RILP;SYCP2;ADH5;MIXL1;HES1 GO:0015347KCsodium-independent organic anion transmembrane transporter activity0@@:o?%]$@hzg?~ ?SLCO5A1;SLCO3A1;SLCO6A1 GO:0008379'thioredoxin peroxidase activity@@qK?'Ş5@V[:j?~ ? PRDX4;PRDX2 GO:0005539!glycosaminoglycan binding`k@$@dǸ!@uK$1@=sq~?~ ?D<FGF7;COL5A3;LPL;SFRP1;EPYC;ADAMTS15;TENM1;COLQ;TGFBR2;EGFLAM GO:0008138>6protein tyrosine/serine/threonine phosphatase activityF@@)?@[ס?~ ? CDKN3;DUSP18;DUSP16;SSH1  GO:0008144  drug binding @F@ Ӕ2Lo?@ F? Lׁ?~ ? CTPS1;CNR1;SIGMAR1;SYN3;JAK3;MT2A;ACSM4;DDX23;ANKK1;CD320;AKT3;DRD2;KIF21B;CHID1;CKMT2;NLRP11;HYOU1;EPHA6;MAT1A;ACTR3B;ALPK2;NOLC1;PBK;DNAH2;SFRP1;DPYS;IARS;HSPA4L;MYH14;CYP8B1;TXK;ABCC10;EPHA1;STK17A;NUAK2;RPS6KA2;TRIT1;STK32B;ADCY2;TGFBR2;STK38L;ACSS2;A  GO:0051920 peroxiredoxin activity  @@ ,'o? evqv&+@ E8_?~ ?  PRDX4;PRDX2  GO:0004725- %protein tyrosine phosphatase activity Y@@  !v? {/ @ Y+`:a?~ ?, $PTPN3;CDKN3;DUSP18;PTPN1;DUSP16;SSH1  GO:0070181, $small ribosomal subunit rRNA binding &@@ ? #@ |cp?~ ?  MRPS18C;NSUN4  GO:00085283 +G protein-coupled peptide receptor activity a@@ '@  MrC@ +?~ ?1 )F2R;GLP2R;SIGMAR1;LTB4R;TACR1;GPR35;ACKR2 GO:0001228PHDNA-binding transcription activator activity, RNA polymerase II-specific{@.@YDKZ @ZZ?f#[i?~ ?bZTOX2;POU2F2;HMGA2;ESRRB;MITF;CREBRF;GBX2;FOXF1;BARHL1;NFATC2;GATA2;ONECUT3;TXK;MEIS3;MIXL1 GO:0001653!peptide receptor activityb@@ PTp@uL"jh@.?~ ?1)F2R;GLP2R;SIGMAR1;LTB4R;TACR1;GPR35;ACKR2 GO:0022839"ion gated channel activityt@(@EЂ'@et?2^V?~ ?SKCNR1;KCNMA1;SNAP25;KCNJ3;ANO3;TRPA1;CACNA2D2;ANO5;KCNC3;GABRR3;VDAC3;CHRNA6 GO:0003906A9DNA-(apurinic or apyrimidinic site) endonuclease activity*@@$?=Cpf @RPɺ1?~ ? HMGA2;APLF GO:0017017A9MAP kinase tyrosine/serine/threonine phosphatase activity*@@$?=Cpf @RPɺ1?~ ? DUSP18;DUSP16 GO:0003779 actin binding0z@,@?(@$Q?RH?~ ?ZRKCNMA1;PLS1;AVIL;HPCA;VASP;ACTR3B;PPP1R18;CNN1;MYH14;ABLIM3;ADD1;SSH1;SNTG2;STK38L GO:0008270zinc ion binding@7@8`-@r,?z?~ ?MT1X;MT1F;MT1H;MT1M;MT1E;ZNF208;ESRRB;MT2A;TIMM8B;TRIM67;SLC30A8;ZMAT1;PTPN1;CPM;DPYS;SOD1;TIMM13;GATA2;L3MBTL4;ADAMTS15;S100A3;TRIT1;ADH5 GO:0022836gated channel activityu@(@;orV@ BO??~ ?SKCNR1;KCNMA1;SNAP25;KCNJ3;ANO3;TRPA1;CACNA2D2;ANO5;KCNC3;GABRR3;VDAC3;CHRNA6 GO:0004029-%aldehyde dehydrogenase (NAD) activity,@@?6>@Bf!8?~ ? ALDH1A2;ADH5 GO:0033549'MAP kinase phosphatase activity,@@?6>@Bf!8?~ ? DUSP18;DUSP16 GO:0046982+#protein heterodimerization activity@}@.@+V?~ ? ILDR1;SCARB1Dlg*" ,! ," ,# ,$ ,% ,& ,' ,( ,) ,* ,+ ,, ,- ,. ,/ ,0 ,1 ,2 ,3 ,4 ,5 ,6 ,7 ,8 ,9 ,: ,; ,< ,= ,> ,? ,  GO:0000980G ?RNA polymerase II distal enhancer sequence-specific DNA binding X@@ L0q+? :gb@ A6GX?~ ?& ESRRB;ZNF281;H2AFZ;GATA2;MIXL1! GO:0019903#!protein phosphatase binding!`@@!#U@!L |@!pߺ?~ !?'!JAK3;PTPN1;CD22;SOD1;CDH2;PPME1" GO:00551068"0ubiquitin-protein transferase regulator activity"1@@"]5& ?"U@"Cg?~ "?" TRIB2;CDC20# GO:0005005.#&transmembrane-ephrin receptor activity#1@@#]5& ?#U@#Cg?~ #?# EPHA6;EPHA1$ GO:0052689+$#carboxylic ester hydrolase activity$a@@$.}H& @$,m*@$:'U?~ $?%$CES2;LPL;IARS;PLB1;PPME1;MGLL% GO:00085090%(anion transmembrane transporter activity%pt@&@%'L@%e.:?%:B?~ %?T%LSLC16A1;SLCO5A1;SLCO3A1;ANO3;SLC4A3;SLC38A2;ANO5;ABCC10;GABRR3;VDAC3;SLCO6A1& GO:0008092$&cytoskeletal protein binding&`@9@&^oO1@&?& `?~ &?&CLIP2;PTPN3;KCNMA1;PLS1;KIF21B;AVIL;HPCA;SPEF1;VASP;ACTR3B;PPP1R18;CNN1;CDK5RAP2;ADORA2A;MYH14;CDH2;CDH20;BIRC5;LZTS1;ABLIM3;ADD1;SSH1;SNTG2;STK38L;PDE4B' GO:0031492'nucleosomal DNA binding'E@@'(+?'$>@'B Yr?~ '?'HMGA2;RCC1;H2AFZ( GO:0005229A(9intracellular calcium activated chloride channel activity(2@@(в6?(Rw"@(=Υ?~ (?( ANO3;ANO5) GO:0061778/)'intracellular chloride channel activity)2@@)в6?)Rw"@)=Υ?~ )?) ANO3;ANO5* GO:00083202**protein transmembrane transporter activity*3@@*C02d?*{AH@*qk?~ *?* AZGP1;SEC61A1+ GO:0016780K+Cphosphotransferase activity, for other substituted phosphate groups+3@@+C02d?+{AH@+qk?~ +?+ PIGF;SGMS2, GO:0008301,DNA binding, bending,3@@,C02d?,{AH@,qk?~ ,?, HMGA2;TRERF1- GO:0005003 -ephrin receptor activity-3@@-C02d?-{AH@-qk?~ -?- EPHA6;EPHA1. GO:00050886..Ras guanyl-nucleotide exchange factor activity.o@"@.ة@.I?.BGL?~ .?9.1FGF7;JAK3;ST5;RCC1;IL2RB;FRS3;RGL2;ARHGEF40;IL2RA/ GO:0022843-/%voltage-gated cation channel activity/a@@/D[4p@/D[@/ճ q?~ /?//'CNR1;KCNMA1;SNAP25;KCNJ3;CACNA2D2;KCNC30 GO:0008134$0transcription factor binding0@2@0Jp'@0=N?0; x?~ 0?v0nCCND1;HMGA2;ESRRB;TRIB2;TRERF1;TGFB1I1;CDKN2A;POLR1E;BCL10;HDAC7;TLE3;NOLC1;KDM1A;NFATC2;GATA2;ADD1;MIXL1;HES11 GO:00312671small GTPase binding18@0@1D&K$@1>:?1q3G?~ 1?a1YFGF7;JAK3;ST5;RCC1;IL2RB;XPO7;FRS3;TSC2;RASSF5;SH3BP1;RGL2;SOD1;ARHGEF40;BIRC5;RILP;IL2RA2 GO:0016538K2Ccyclin-dependent protein serine/threonine kinase regulator activity2F@@2Tq?28m) @2ebAy?~ 2?2CCND1;CDKN2A;CKS23 GO:000538533+zinc ion transmembrane transporter activity34@@3K?3'Ş@3x6Fq?~ 3?3SLC39A14;SLC30A84 GO:00046724protein kinase activity4H@2@4Sk''@4`1_h?4U9?~ 4?r4jCCND1;FGF7;JAK3;TRIB2;ANKK1;AKT3;EPHA6;ALPK2;PBK;TXK;EPHA1;EFNB1;STK17A;NUAK2;RPS6KA2;STK32B;TGFBR2;STK38L5 GO:00036825chromatin binding5@@.@5µ&#@5RX?5,e"?~ 5?_5WMLLT3;HMGA2;MITF;GPER1;TSHZ3;RCC1;HDAC7;CKS2;H2AFZ;KDM1A;NFATC2;GATA2;APTX;MEIS3;WBP2NL6 GO:00055246 ATP binding6@A@6Ш:@6"?68?~ 6?6CTPS1;SYN3;JAK3;ACSM4;DDX23;ANKK1;AKT3;KIF21B;CKMT2;NLRP11;HYOU1;EPHA6;MAT1A;ACTR3B;ALPK2;NOLC1;PBK;DNAH2;IARS;HSPA4L;MYH14;TXK;ABCC10;EPHA1;STK17A;NUAK2;RPS6KA2;TRIT1;STK32B;ADCY2;TGFBR2;STK38L;ACSS2;ABCF2;AK27 GO:0022884870macromolecule transmembrane transporter activity76@@7)?7@7D cc?~ 7?7 AZGP1;SEC61A18 GO:00170758syntaxin-1 binding86@@8)?8@8D cc?~ 8?8 SNAP25;VAMP29 GO:0042803)9!protein homodimerization activity9H@6@9[vgq.@9&? |?9^u߯?~ 9?9~GZMA;EXT1;SLC16A1;DRD2;ASGR1;PRDX4;SCARB1;DLK2;SLC30A8;TSC2;TPST2;SOD1;CDH2;CDH20;TENM1;MAD2L1;ADD1;CADM1;MGLL;ADH5;MIXL1;HES1: GO:0032559%:adenyl ribonucleotide binding:@B@:2:;@:`$Vt[?:rv#?~ :?:CTPS1;SYN3;JAK3;ACSM4;DDX23;ANKK1;AKT3;KIF21B;CKMT2;NLRP11;HYOU1;EPHA6;MAT1A;ACTR3B;ALPK2;NOLC1;PBK;DNAH2;IARS;HSPA4L;MYH14;TXK;ABCC10;EPHA1;STK17A;NUAK2;RPS6KA2;TRIT1;STK32B;ADCY2;TGFBR2;STK38L;PDE4B;ACSS2;ABCF2;AK2; GO:01401034;,catalytic activity, acting on a glycoprotein;7@@;&|p?;qhR@;GyU?~ ;?; GCNT4;MGAT3< GO:0000979E<=RNA polymerase II core promoter sequence-specific DNA binding<7@@<&|p?<qhR@<GyU?~ <?< GBX2;H2AFZ= GO:0004622"=lysophospholipase activity=7@@=&|p?=qhR@=GyU?~ =?= PLB1;MGLL> GO:0030215#>semaphorin receptor binding>7@@>&|p?>qhR@>GyU?~ >?> SH3BP1;SEMA6B? GO:0038024?cargo receptor activity?T@@?ˋ3t??w|H@?Nz9(?~ ?? ?ILDR1;ASGR1;SCARB1;ACKR2D*l= e'}@ ,A ,B ,C ,D ,E ,F ,G ,H ,I ,J ,K ,L ,M ,N ,O ,P ,Q ,R ,S ,T ,U ,V ,W ,X ,Y ,Z ,[ ,\ ,] ,^ ,_ ,@ GO:0001158.@&enhancer sequence-specific DNA binding@]@@@Ԇ6Kb@@Bch@@J/?~ @?&@ESRRB;ZNF281;H2AFZ;GATA2;MIXL1A GO:0015103:A2inorganic anion transmembrane transporter activityAc@@Asp@A7@;pf@A$?~ A?,A$ANO3;SLC4A3;ANO5;ABCC10;GABRR3;VDAC3B GO:0017016BRas GTPase bindingB@.@B~ݪ#@Bz*Jg?B]$?~ B?\BTFGF7;JAK3;ST5;RCC1;IL2RB;XPO7;FRS3;RASSF5;SH3BP1;RGL2;SOD1;ARHGEF40;BIRC5;RILP;IL2RAC GO:0016772GC?transferase activity, transferring phosphorus-containing groupsC@9@C8RKI2@CF?C$?~ C?CCCND1;FGF7;JAK3;TRIB2;ANKK1;AKT3;PIGF;POLR1E;CKMT2;EPHA6;ALPK2;PBK;POLN;TXK;POLE3;EPHA1;EFNB1;STK17A;NUAK2;RPS6KA2;STK32B;TGFBR2;STK38L;SGMS2;AK2D GO:0008375.D&acetylglucosaminyltransferase activityDJ@@Dfs?DRX @D?~ D?DEXT1;GCNT4;MGAT3E GO:0030554!Eadenyl nucleotide bindingEȗ@B@E/'<@Em͆?E  U2L?J؃6@J&?~ J?JANO3;ANO5;GABRR3;VDAC3K GO:0003887,K$DNA-directed DNA polymerase activityK9@@K !v?K`@K~x?~ K?K POLN;POLE3L GO:0072509DL<divalent inorganic cation transmembrane transporter activityL9@@L !v?L`@L~x?~ L?LSLC39A14;SLC30A8M GO:00052490M(voltage-gated potassium channel activityMV@@M)?M!@M1<+P?~ M?!MKCNMA1;SNAP25;KCNJ3;KCNC3N GO:0050840$Nextracellular matrix bindingNK@@NI774?N9!@N[Z?~ N?NITGA9;SMOC1;ADAMTS15O GO:0046914$Otransition metal ion bindingO@:@OT-{3@O FZ?Oc: ?~ O?OMT1X;MT1F;MT1H;MT1M;MT1E;ZNF208;ESRRB;MT2A;TIMM8B;TRIM67;SLC30A8;ZMAT1;PTPN1;CPM;DPYS;SOD1;TIMM13;GATA2;L3MBTL4;ADAMTS15;CYP2D7;CYP8B1;S100A3;TRIT1;ADCY2;ADH5P GO:0008565$Pprotein transporter activityP@V@@PG'9?PnO@P >?~ P?"PAZGP1;TIMM13;TOMM5;SEC61A1Q GO:0001637;Q3G protein-coupled chemoattractant receptor activityQ:@@Qfs?Q7@;pf@Q?J?~ Q?Q GPR35;ACKR2R GO:0004950#Rchemokine receptor activityR:@@Rfs?R7@;pf@R?J?~ R?R GPR35;ACKR2S GO:0043015Sgamma-tubulin bindingS:@@Sfs?S7@;pf@S?J?~ S?SCDK5RAP2;PDE4BT GO:0016405TCoA-ligase activityT:@@Tfs?T7@;pf@T?J?~ T?T ACSM4;ACSS2U GO:00051041U)fibroblast growth factor receptor bindingU:@@Ufs?U7@;pf@U?J?~ U?U FGF7;FRS3V GO:0005216Vion channel activityVy@(@V@V֐?V$Q?~ V?SVKCNR1;KCNMA1;SNAP25;KCNJ3;ANO3;TRPA1;CACNA2D2;ANO5;KCNC3;GABRR3;VDAC3;CHRNA6W GO:00050852W*guanyl-nucleotide exchange factor activityWt@$@W:<@Wh?W.R?~ W?>W6FGF7;JAK3;ST5;RCC1;IL2RB;FRS3;RGL2;PSD3;ARHGEF40;IL2RAX GO:0016765SXKtransferase activity, transferring alkyl or aryl (other than methyl) groupsXL@@XQ?XE@Xuu쇵?~ X?XDPH2;MAT1A;TRIT1Y GO:0019955Ycytokine bindingY_@@Y @Y+p@YldY[?~ Y?'YIL27RA;IL2RB;ACKR2;TGFBR2;IL2RAZ GO:0042802!Zidentical protein bindingZ@C@ZIXoq;?@Z ?Z;!?~ Z?ZCTPS1;GZMA;EXT1;ILDR1;SLC16A1;DRD2;ASGR1;PRDX4;SCARB1;DLK2;EPM2AIP1;SLC30A8;HPCA;BCL10;FRS3;MAT1A;TSC2;EID2B;TRPA1;INHBA;EPOR;SFRP1;ADORA2A;IER5;CLDN6;TPST2;SOD1;CDH2;CDH20;BIRC5;PRPF3;TENM1;MAD2L1;ADD1;CADM1;MGLL;ADH5;MIXL1;HES1[ GO:0046875[ephrin receptor binding[;@@[L?[3nY@[Dy?~ [?[ PTPN1;EFNB1\ GO:0034711\inhibin binding\@?\qK?\'Ş%@\9>Ǹ?~ \? \INHBA] GO:0005026B]:transforming growth factor beta receptor activity, type II]@?]qK?]'Ş%@]9>Ǹ?~ ]?]TGFBR2^ GO:00318026^.type 5 metabotropic glutamate receptor binding^@?^qK?^'Ş%@^9>Ǹ?~ ^?^ADORA2A_ GO:00040285_-3-chloroallyl aldehyde dehydrogenase activity_@?_qK?_'Ş%@_9>Ǹ?~ _?_ALDH1A2DlXyB` ,a ,b ,c ,d ,e ,f ,g ,h ,i ,j ,k ,l ,m ,n ,o ,p,q,r,s,t,u,v,w,x,y,z,{,|,},~,,` GO:0002054`nucleobase binding`@?`qK?`'Ş%@`9>Ǹ?~ `? `DPYSa GO:00165326a.superoxide dismutase copper chaperone activitya@?aqK?a'Ş%@a9>Ǹ?~ a? aSOD1b GO:0030881$bbeta-2-microglobulin bindingb@?bqK?b'Ş%@b9>Ǹ?~ b? bHFEc GO:0001875,c$lipopolysaccharide receptor activityc@?cqK?c'Ş%@c9>Ǹ?~ c?cSCARB1d GO:0004111 dcreatine kinase activityd@?dqK?d'Ş%@d9>Ǹ?~ d? dCKMT2e GO:0004784%esuperoxide dismutase activitye@?eqK?e'Ş%@e9>Ǹ?~ e? eSOD1fTAGLN2f LOC647234g LOC648140gIFNA17hTMEM40 hEPHA4i LOC348840 jCCL28 kCHD1LlTMEM67m LOC653867 nPIGM oDERL1 pCSPG6 qMORC1 rRCHY1 sHDGF tBCL10u LOC653310 vSSX5wNIFIE14x LOC150223 yMTHFSzKIAA0776{FIGNL1| LOC653809 }SQLE ~AP3B1 LOC653219Dl''#,,,,,,,,KIAA0895LTB4DH TM2D1 PYGO2EIF2S3PAGE2Bmimitin XAGE10=K_8X>  Oh+'0x8@L X dp???QC@L0@?n ՜.+,00 8@ H ^  Table S10  Worksheets  !"#$%&'()*+,-./0123456789:;<=?@ABCDEGHIJKLMRoot EntryF0p]Book |zSummaryInformation(>DocumentSummaryInformation8F