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Warning Text %XTableStyleMedium2PivotStyleLight16`Ycontent]Supplementary Table 1 4icontentSupplementary table Data SourcesS1sGenetic correlation genetic overlap and genetic causation results between circulating inflammatory proteins and ALSS2:Shared sites between C-C motif chemokine 28 levels and ALSS32Shared sites between Interleukin-18 levels and ALSS4;Shared sites between C-X-C motif chemokine 1 levels and ALSS5GShared sites between Leukemia inhibitory factor receptor levels and ALSS6kResults of Forward Mendelian Randomization Analysis between 91 inflammatory proteins and ALS (snp p<5e-8)S7FExclude rs112665079 and reperform the Mendelian randomization analysisS8^Results of Reverse Mendelian Randomization Analysis between 91 inflammatory proteins and ALSS9TRIT PMID/SourceYear SamplesizeAncestry$91 circulating inflammatory proteinsEUR Amyotrophic lateral sclerosis/91 details of circulating inflammatory proteins First authorStudy accessionReported traitDiscovery sample numberReplication sample numberZhao JH GCST90274783C-X-C motif chemokine 6 levels" 14744 European" 1585 European, NR GCST90274759Adenosine Deaminase levels" 14736 European GCST90274785DDelta and Notch-like epidermal growth factor-related receptor levels" 14735 European GCST90274761 Axin-1 levels" 11793 European GCST90274787"Fibroblast growth factor 19 levels GCST90274788"Fibroblast growth factor 21 levels" 14743 European GCST90274764Eotaxin levels" 14734 European GCST90274765C-C motif chemokine 19 levels GCST90274766C-C motif chemokine 20 levels GCST90274767C-C motif chemokine 23 levels GCST90274768C-C motif chemokine 25 levels GCST90274794Interferon gamma levels GCST90274795Interleukin-10 levels GCST90274771'Natural killer cell receptor 2B4 levels GCST90274772CD40L receptor levels GCST90274773&T-cell surface glycoprotein CD5 levels GCST90274774.T-cell surface glycoprotein CD6 isoform levels GCST90274775&CUB domain-containing protein 1 levels GCST90274801Interleukin-17A levels" 11784 European GCST90274777Cystatin D levels GCST90274778Fractalkine levels GCST90274804 interleukin-18 receptor 1 levels GCST90274780C-X-C motif chemokine 10 levels GCST90274781C-X-C motif chemokine 11 levels GCST90274758DEukaryotic translation initiation factor 4E-binding protein 1 levels GCST90274784C-X-C motif chemokine 9 levels GCST90274760Artemin levels" 11778 European GCST90274786Protein S100-A12 levels GCST90274762beta-nerve growth factor levels GCST90274763Caspase 8 levels GCST90274789"Fibroblast growth factor 23 levels GCST90274790!Fibroblast growth factor 5 levels" 11789 European GCST90274791+Fms-related tyrosine kinase 3 ligand levels GCST902747922Glial cell line-derived neurotrophic factor levels GCST90274793Hepatocyte growth factor levels GCST90274769C-C motif chemokine 28 levels GCST90274770C-C motif chemokine 4 levels GCST90274796,Interleukin-10 receptor subunit alpha levels GCST90274797+Interleukin-10 receptor subunit beta levels GCST90274798"Interleukin-12 subunit beta levels GCST90274799Interleukin-13 levels" 11792 European GCST90274800,Interleukin-15 receptor subunit alpha levels GCST90274776-Macrophage colony-stimulating factor 1 levels GCST90274802Interleukin-17C levels GCST90274803Interleukin-18 levels GCST90274779C-X-C motif chemokine 1 levels GCST90274805Interleukin-1-alpha levels" 11788 European GCST90274806Interleukin-2 levels GCST90274807Interleukin-20 levels GCST90274782C-X-C motif chemokine 5 levels GCST90274808,Interleukin-20 receptor subunit alpha levels GCST90274809.Interleukin-22 receptor subunit alpha-1 levels GCST90274810Interleukin-24 levels" 11785 European GCST90274811*Interleukin-2 receptor subunit beta levels GCST90274812Interleukin-33 levels GCST90274813Interleukin-4 levels GCST90274814Interleukin-5 levels GCST90274815Interleukin-6 levels GCST90274816Interleukin-7 levels GCST90274817Interleukin-8 levels GCST90274818CLatency-associated peptide transforming growth factor beta 1 levels GCST90274819!Leukemia inhibitory factor levels GCST90274820*Leukemia inhibitory factor receptor levels GCST90274821)Monocyte chemoattractant protein-1 levels" 14733 European GCST90274822)Monocyte chemoattractant protein 2 levels GCST90274823)Monocyte chemoattractant protein-3 levels" 11783 European GCST90274824)Monocyte chemoattractant protein-4 levels GCST90274825)Macrophage inflammatory protein 1a levels GCST90274826!Matrix metalloproteinase-1 levels GCST90274827"Matrix metalloproteinase-10 levels GCST90274828Neurturin levels" 11791 European GCST90274829Neurotrophin-3 levels GCST90274830Osteoprotegerin levels GCST90274831Oncostatin-M levels GCST90274832'Programmed cell death 1 ligand 1 levels GCST90274833Stem cell factor levels GCST90274834SIR2-like protein 2 levels GCST902748350Signaling lymphocytic activation molecule levels GCST90274836Sulfotransferase 1A1 levels GCST90274837STAM binding protein levels GCST90274838'Transforming growth factor-alpha levels GCST90274839Tumor necrosis factor levels GCST90274840TNF-beta levels GCST90274841:Tumor necrosis factor receptor superfamily member 9 levels GCST902748429Tumor necrosis factor ligand superfamily member 14 levels GCST90274843,TNF-related apoptosis-inducing ligand levels GCST90274844.TNF-related activation-induced cytokine levels GCST90274845#Thymic stromal lymphopoietin levels GCST902748469Tumor necrosis factor ligand superfamily member 12 levels GCST90274847+Urokinase-type plasminogen activator levels GCST90274848+Vascular endothelial growth factor A levels$Supplementary Table 1. 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