ࡱ> 78  !"#$%&'()*+,-./0123456Root Entry FΉ@L'WorkbookYaETExtDataRSummaryInformation(  6d@@@@DD@@@@BT@@@DDD|f@@|f|fB|fB@@@@|f|d|`@|`@|@|@| Oh+'0@H`p AdministratorKarthic WPS Office@&@ ՜.+,D՜.+,HP X`hp ZO\pVelthic Ba== Py8X@"1[SO1Calibri1Calibri1Calibri1[SO1[SO1.Times New Roman1Calibri1Calibri1 Calibri1Calibri14Calibri1 Calibri1Calibri1Calibri1Calibri1,6Calibri16Calibri16Calibri1 Calibri1>Calibri14Calibri1<Calibri1Calibri1?Calibri1h6Calibri1Calibri1 Calibri1.Times New Roman1.Times New Roman"$"#,##0_);\("$"#,##0\)!"$"#,##0_);[Red]\("$"#,##0\)""$"#,##0.00_);\("$"#,##0.00\)'""$"#,##0.00_);[Red]\("$"#,##0.00\)7*2_("$"* #,##0_);_("$"* \(#,##0\);_("$"* "-"_);_(@_).))_(* #,##0_);_(* \(#,##0\);_(* "-"_);_(@_)?,:_("$"* #,##0.00_);_("$"* \(#,##0.00\);_("$"* "-"??_);_(@_)6+1_(* #,##0.00_);_(* \(#,##0.00\);_(* "-"??_);_(@_)\$#,##0_);\(\$#,##0\)\$#,##0_);[Red]\(\$#,##0\) \$#,##0.00_);\(\$#,##0.00\)% \$#,##0.00_);[Red]\(\$#,##0.00\)i2_ ""* #,##0_ ;_ ""* \-#,##0_ ;_ ""* "-"_ ;_ @_ 61_ * #,##0.00_ ;_ * \-#,##0.00_ ;_ * "-"??_ ;_ @_ .)_ * #,##0_ ;_ * \-#,##0_ ;_ * "-"_ ;_ @_ y:_ ""* #,##0.00_ ;_ ""* \-#,##0.00_ ;_ ""* "-"??_ ;_ @_  0.0000_ 0_  0.000_                    /        *  ,  /    +  ,  +  ,  /    +  1  9  1  5  7  3  >  9  -     ff7       *  @   @   @ @    / `@ @ +        a@    x  x@ @   x  | x x x 8@ @ ||I:}-} 0_ ;}-} 0_ ;}-} 0_ ;}-} 0_ ;}A} 0_ ;ef-#,#}A} 0_ ;ef-#,#}A} 0_ ;ef-#,#}A} 0_ ;ef-#,#}A} 0_ ;ef-#,#}A} 0_ ;ef -#,#}A} 0_ ;L-#,#}A} 0_ ;L-#,#}A} 0_ ;L-#,#}A} 0_ ;L-#,#}A} 0_ ;L-#,#}A} 0_ ;L -#,#}A} 0_ ;23-#,#}A} 0_ ;23-#,#}A} 0_ ;23-#,#}A} 0_ ;23-#,#}A}  0_ ;23-#,#}A}! 0_ ;23 -#,#}A}" 0_ ;-#,#}A}# 0_ ;-#,#}A}$ 0_ ;-#,#}A}% 0_ ;-#,#}A}& 0_ ;-#,#}A}' 0_ ; -#,#}A}( 0_ ;-#,#}}) }0_ ;-#,# ;_ -"?? _ }}* 0_ ;-#,#??? ;_ ???-"?? ???_ ???}-}/ 0_ ;}-}0 0_ ;}A}1 a0_ ;-#,#}A}2 0_ ;-#,#}A}3 0_ ;-#,#}A}4 0_ ;?-#,#}-}5 0_ ;}-}6 0_ ;}}7 ??v0_ ;̙-#,# ;_ -"?? _ }A}8 }0_ ;-#,#}A}9 e0_ ;-#,#}}}: ;-#,# ;_ -"?? _ }}; ??? ;-#,#??? ;_ ???-"?? ???_ ???}-}=  ;}U}>  ;-#,# ;_ }-}?  ;}-}@  ;}-}B  ;}-}C  ;}-}D  ;}-}E  ;}x}F  ;-# ; ???-" ???_ }x}G  ;-# ; ???-" ???_  20% - Accent1M 20% - Accent1 ef % 20% - Accent2M" 20% - Accent2 ef % 20% - Accent3M& 20% - Accent3 ef % 20% - Accent4M* 20% - Accent4 ef % 20% - Accent5M. 20% - Accent5 ef % 20% - Accent6M2 20% - Accent6  ef % 40% - Accent1M 40% - Accent1 L % 40% - Accent2M# 40% - Accent2 L˭ % 40% - Accent3M' 40% - Accent3 L % 40% - Accent4M+ 40% - Accent4 L % 40% - Accent5M/ 40% - Accent5 L % 40% - Accent6M3 40% - Accent6  L % 60% - Accent1M 60% - Accent1 23 % 60% - Accent2M$ 60% - Accent2 23 % 60% - Accent3M( 60% - Accent3 23 % 60% - Accent4M, 60% - Accent4 23f % 60% - Accent5M0 60% - Accent5 23 %! 60% - Accent6M4 60% - Accent6  23Ў % "Accent1AAccent1 [ % #Accent2A!Accent2 }1 % $Accent3A%Accent3  % %Accent4A)Accent4  % &Accent5A-Accent5 Dr % 'Accent6A1Accent6  pG %(Bad9Bad  %) Calculation Calculation  }% * Check Cell Check Cell  %????????? ???+ Comma,( Comma [0]-&Currency.. Currency [0]/Explanatory TextG5Explanatory Text %0 K Followed Hyperlink % 1Good;Good  a%2 Heading 1G Heading 1 DTj%[3 Heading 2G Heading 2 DTj%[4 Heading 3G Heading 3 DTj%?5 Heading 49 Heading 4 DTj%69 Hyperlink % 7InputuInput ̙ ??v% 8 Linked CellK Linked Cell }% 9NeutralANeutral  e%"Normal :Noteb Note   ;OutputwOutput  ???%????????? ???<$Percent =Title1Title DTj% >TotalMTotal %[[? Warning Text? Warning Text %XTableStyleMedium2PivotStyleLight16`Ccontent?GSupplementary Table 6 !  ;4LcontentSupplementary table Data SourcesS1sGenetic correlation genetic overlap and genetic causation results between circulating inflammatory proteins and ALSS2:Shared sites between C-C motif chemokine 28 levels and ALSS32Shared sites between Interleukin-18 levels and ALSS4;Shared sites between C-X-C motif chemokine 1 levels and ALSS5GShared sites between Leukemia inhibitory factor receptor levels and ALSS6kResults of Forward Mendelian Randomization Analysis between 91 inflammatory proteins and ALS (snp p<5e-8)S7FExclude rs112665079 and reperform the Mendelian randomization analysisS8^Results of Reverse Mendelian Randomization Analysis between 91 inflammatory proteins and ALSS9NArsIDChrBPRegionLeadSNPs NearestGeneFuncCADDRDBP.PLACOstartend PP.H0.abf PP.H1.abf PP.H2.abf PP.H3.abf PP.H4.abf9p21.2MOB3Bintronic1f rs10967965 intergenic downstreamUTR3upstreamexonic ncRNA_exonic rs112440349q34.2 rs10793960OBP2B rs10901246 rs10793958 rs10901247 rs1052517 rs11244035 rs10793957 rs10736860 rs10793959LCN1P1 rs10901248 rs11244038 rs11244049 rs10793961 rs11244041ABO:RP11-430N14.4 rs10901252 rs10793962 rs1137827 rs11244061ABO rs11244079LCN1P2_Supplementary Table 6. Shared sites between leukemia inhibitory factor receptor levels and ALS.R1 2 4<45Or55%6U66&ccu PK![Content_Types].xmlN0EH-J@%ǎǢ|ș$زULTB l,3;rØJB+$G]7O٭V&vDJ]jw );ɱ@iKz(H^_6E rW+Rj!-b_$ raBcaiǯ]N4wG.( e)s,~p'T젎KT*"a$. lx$|Q%&U6+ "(&`wOw*(*xNk !KwhLJBv2Q$$G?,FO}Wn0o~>Z2z??}hlG$»O;,񘿙(FIJ@1vޜ#c;x8H xm:L71FwˈhFA5wVj \vclѼMQ*QS,=M1v>!V\H`'>"ΐ*I /sAH{>U𱍄 S+LrjEr8灉 0e^?BlnqX yb#$SCĘi7FII؏JytCwJ7V&e'35̬a2 ^'$=SvĹyVz?(=4Koc-BWhЛJ`~d{B(9ŇB4pN_:qybv2L`"Ǚx N5_9D:^ӷYrYf.xQÍAfky*k.(7!aLfvh-U WVX,.+TjeV7`FpmB*Oy|LReۊvL[$rI&b:yhi˔ZT(X4ZEs v@SS)htvJ&@Yǟ>&ԎP'[D#xHo(Kƅ!עAB$%IW/@S![m %YyA$L1"ϵT_, =oLgkj*!G3$Ve4BvׂqD10k!)8R Mˮsu6R3Ds3-UQ]ӭb 6ˋ5y".KZrN(랣!ԖYuV]ڽc3I\][#:?حV- MJiÅ ?B~?DC}&)eCPK! ѐ'theme/theme/_rels/themeManager.xml.relsM 0wooӺ&݈Э5 6?$Q ,.aic21h:qm@RN;d`o7gK(M&$R(.1r'JЊT8V"AȻHu}|$b{P8g/]QAsم(#L[PK-![Content_Types].xmlPK-!֧6 0_rels/.relsPK-!kytheme/theme/themeManager.xmlPK-!&ϟ6theme/theme/theme1.xmlPK-! ѐ'theme/theme/_rels/themeManager.xml.relsPK]  ZO  DF  dMbP?_*+%,&?'?(?)?",??& U} U@} @ @}  @ W,X,,,,X, , F F G G G G G G G G G G G G G G G G G G>@dggD ZO UH`  dMbP?_*+%,&?'?(?)?",??& U}  @} ` @} ` @}  @}  @}  @} @} ` @} ` @}  @}  @;,A,@,@,@,@,@,@,@ ,@ ,@ ,@ ,@ ,@,@,@,@,@,@,@,@,@,@ HK&HHHHHHHHHHHHHHHH B B B B B B B B B  B  B  B  B!  B" B# B$ B%E C*C"@CX C& C* C' C(~ C@ C) C>~GC= C^̃CH  Dv_E8 CմC1?DYOp8C'?C|? C1C"@CBq  C2 C3 C4 C,C!rh?~ C@ Ck*> Cbq CZq  DY[KVH5= DV<CU?C`jSdM?CL ? C5C"@Cq  C2 C6 C4 C,CMbp?~ C@ C:0y> Cbq CZq  DY[KVH5= DV<CU?C`jSdM?CL ? C7C"@Cq  C2 C6 C4 C,C+ @~ C@ Cq> Cbq CZq  DY[KVH5= DV<CU?C`jSdM?CL ? C8C"@Cq  C2 C3 C4 C-CA@C@ C|< > Cbq CZq  DY[KVH5= DV<CU?C`jSdM?CL ? C9C"@Cq  C2 C9 C4 C/C;On?~ C@ C8J=> Cbq CZq  DY[KVH5= DV<CU?C`jSdM?CL ? C:C"@C%r  C2 C3 C4 C+Cn@~ C@ C+i)+0> Cbq CZq  DY[KVH5= DV<CU?C`jSdM?CL ? C6 C"@C'r  C2 C6 C4 C+ CK?~ C@ Cj%i= Cbq CZq  DY[KVH5= DV< CU? C`jSdM? CL ? C; C"@Cbr  C2 C3 C4 C+ Cxi@~ C@ C۞q$> Cbq CZq  DY[KVH5= DV< CU? C`jSdM? CL ? C< C"@C>xr  C2 C3 C= C+ C%C?~ C@ Cg!> Cbq CZq  DY[KVH5= DV< CU? C`jSdM? CL ? C> C"@C~r  C2 C6 C= C+ Cy&1?~ C@ C?"nE> Cbq CZq  DY[KVH5= DV< CU? C`jSdM? CL ? C? C"@Cjr  C2 C@ C= C+ C-?~ C@ Ck = Cbq CZq  DY[KVH5= DV< CU? C`jSdM? CL ? C3C"@C;s  C2 C3 C= C+C6@C@ C=M*~_X> Cbq CZq  DY[KVH5= DV<CU?C`jSdM?CL ? CAC"@Cqs  C2 C6 C= C+C_@C@ COh D!> Cbq CZq  DY[KVH5= DV<CU?C`jSdM?CL ? CBC"@C~ss  C2 C6 C= C+CX9v?~ C@ Cብ> Cbq CZq  DY[KVH5= DV<CU?C`jSdM?CL ? C@C"@CRKt  C2 C@ CC C+C/$@~ C@ C),= Cbq CZq  DY[KVH5= DV<CU?C`jSdM?CL ? CDC"@CL:A C2 C@ CC C0C3@C@ CM֏<= Cbq CZq  DY[KVH5= DV<CU?C`jSdM?CL ? CEC"@Cnt  C2 C@ CC C0C㥛 @~ C@ C 2= Cbq CZq  DY[KVH5= DV<CU?C`jSdM?CL ? CFC"@Cβt  C2 C@ CC C0C%C@ C Cg= Cbq CZq  DY[KVH5= DV<CU?C`jSdM?CL ? CGC"@C-v  C2 CG CH C+C-?~ C@ C; }= Cbq CZq  DY[KVH5= DV<CU?C`jSdM?CL ? CIC"@C: x  C2 C@ CJ C.C@C@ CLa㧝> Cbq CZq  DY[KVH5= DV<CU?C`jSdM?CL ?28>@d ggD DocumentSummaryInformation8tCompObjlx  contentSupplementary Table 6  Worksheetsd ?GKSOProductBuildVer2052-11.1.0.9021 F Microsoft Excel 2003 WorksheetBiff8Excel.Sheet.89q