%A Santhanakrishnan, Aarthi 
%A Tan, Yi Jayne 
%A Saffari, Seyed Ehsan 
%A Zhao, Yi 
%A Ng, Ebonne Y.L. 
%A Ng, Samuel Y.E. 
%A Chia, Nicole S.Y. 
%A Choi, Xinyi 
%A Heng, Dede 
%A Neo, Shermyn 
%A Xu, Zheyu 
%A Tay, Kay Yaw 
%A Au, Wing Lok 
%A Tan, Eng-King 
%A Tan, Louis C.S. 
%A Ng, Adeline S.L. 
%D 2025
%T Carriers of Parkinson’s disease-linked SNCA Rep1 variant have greater non-motor decline: a 4 year follow up study
%! Carriers of Parkinson’s disease-linked SNCA Rep1 variant have greater non-motor decline: a 4 year follow up study
%K genetics, Parkinson’s disease, cognition, memory, apathy
%X Alpha-synuclein gene promoter (SNCA Rep1) polymorphism has been linked to Parkinson's Disease (PD) susceptibility and motor symptom severity, but less is known about its longitudinal relationship with non-motor symptom severity. To address this gap, this is the first longitudinal study over 4 years investigating the relationship between Rep1 allele length and non-motor function amongst 208 early PD patients grouped into long (n = 111) vs. short (n = 97) Rep1 allele carriers. Long Rep1 carriers demonstrated faster decline in global cognition (p = 0.023) and increasing apathy (p = 0.027), with greater decline in attention and memory domains (p = 0.001), highlighting the utility of Rep1 polymorphism in stratifying patients at risk of non-motor symptom decline.
%U https://doi.org/10.18632/aging.206196
%J Aging
%0 Journal Article
%V 17
%N 2
%P 357-364
%R 10.18632/aging.206196
%@ 1945-4589