This article has been retracted: Aging has completed its investigation of this paper. Following communication with the authors, they submitted a letter stating that the images in Figure 5 are incorrect and that the current findings require validation through further experiments. All authors agreed with this and signed the retraction letter. However, our investigation uncovered multiple instances of image duplication with unrelated papers from different institutions. Specifically:
• The immunofluorescent images in Figure 5B are the duplicates of images in Figure 5K of a 2016 paper [5] and in Figure 3D of a concurrently published paper [6].
• The Flow Cytometry images in Figure 5C were also found in earlier published papers [4, 7, 8], two of which are already retracted.
• The images of the wound healing assay in Figure 6C were present in unrelated and already retracted papers [9–11].
• Figures 7A, 7C, presenting western blot data on protein expression in non-small cell lung cancer cells, showed unexpected similarities to western blot bands in Figures 1 and 3–5 of a paper [12] studying lipid accumulation in hepatic cells.
In light of these findings, the editorial decision has been made to retract this paper.
References
- 1. Jiang Z, Song Q, Zeng R, Li J, Li J, Lin X, Chen X, Zhang J, Zheng Y. MicroRNA-218 inhibits EMT, migration and invasion by targeting SFMBT1 and DCUN1D1 in cervical cancer. Oncotarget. 2016; 7:45622–36. https://doi.org/10.18632/oncotarget.9850 [PubMed]
- 2. Cheng D, Fan J, Ma Y, Zhou Y, Qin K, Shi M, Yang J. LncRNA SNHG7 promotes pancreatic cancer proliferation through ID4 by sponging miR-342-3p. Cell Biosci. 2019; 9:28. https://doi.org/10.1186/s13578-019-0290-2 [PubMed]. Retraction in: Cell Biosci. 2023; 13:149. https://doi.org/10.1186/s13578-023-01103-6 [PubMed]
- 3. Geng Z, Wang W, Chen H, Mao J, Li Z, Zhou J. Circ_0001667 promotes breast cancer cell proliferation and survival via Hippo signal pathway by regulating TAZ. Cell Biosci. 2019; 9:104. https://doi.org/10.1186/s13578-019-0359-y [PubMed]
- 4. Wang W, Zhao Y, Yao S, Cui X, Pan W, Huang W, Gao J, Dong T, Zhang S. Nigericin Inhibits Epithelial Ovarian Cancer Metastasis by Suppressing the Cell Cycle and Epithelial-Mesenchymal Transition. Biochemistry (Mosc). 2017; 82:933–41. https://doi.org/10.1134/S0006297917080089 [PubMed]
- 5. Fang W, Guo J, Cao Y, Wang S, Pang C, Li M, Dou L, Man Y, Huang X, Shen T, Li J. MicroRNA-20a-5p contributes to hepatic glycogen synthesis through targeting p63 to regulate p53 and PTEN expression. J Cell Mol Med. 2016; 20:1467–80. https://doi.org/10.1111/jcmm.12835 [PubMed]
- 6. Kong W, Liu X, Yin G, Zheng S, Zhu A, Yu P, Shan Y, Ying R, Zhang J. Extracellular vesicle derived miR-544 downregulates expression of tumor suppressor promyelocytic leukemia zinc finger resulting in increased peritoneal metastasis in gastric cancer. Aging (Albany NY). 2020; 12:24009–22. https://doi.org/10.18632/aging.104082 [PubMed]
- 7. Liu B, Song X, Yan Z, Yang H, Shi Y, Wu J. MicroRNA-525 enhances chondrosarcoma malignancy by targeting F-spondin 1. Oncol Lett. 2019; 17:781–8. https://doi.org/10.3892/ol.2018.9711 [PubMed]. Retraction in: Oncol Lett. 2024; 28:543. https://doi.org/10.3892/ol.2024.14676 [PubMed]
- 8. Zhang Q, Yang D. Allicin suppresses the migration and invasion in cervical cancer cells mainly by inhibiting NRF2. Exp Ther Med. 2019; 17:1523–8. https://doi.org/10.3892/etm.2018.7104 [PubMed]. Retraction in: Exp Ther Med. 2024; 28:370. https://doi.org/10.3892/etm.2024.12659 [PubMed]
- 9. Huang K, Dong B, Wang Y, Tian T, Zhang B. MicroRNA-519 enhances HL60 human acute myeloid leukemia cell line proliferation by reducing the expression level of RNA-binding protein human antigen R. Mol Med Rep. 2015; 12:7830–6. https://doi.org/10.3892/mmr.2015.4455 [PubMed]. Retraction in: Mol Med Rep. 2024; 30:211. https://doi.org/10.3892/mmr.2024.13335 [PubMed]
- 10. Li MY, Liu JQ, Chen DP, Li ZY, Qi B, Yin WJ, He L. p68 prompts the epithelial-mesenchymal transition in cervical cancer cells by transcriptionally activating the TGF-β1 signaling pathway. Oncol Lett. 2018; 15:2111–6. https://doi.org/10.3892/ol.2017.7552 [PubMed]. Retraction in: Oncol Lett. 2024; 28:575. https://doi.org/10.3892/ol.2024.14708 [PubMed]
- 11. You Z, Liu Y, Liu X. Nicotinamide N-methyltransferase enhances the progression of prostate cancer by stabilizing sirtuin 1. Oncol Lett. 2018; 15:9195–201. https://doi.org/10.3892/ol.2018.8474 [PubMed]
- 12. Guo J, Fang W, Sun L, Lu Y, Dou L, Huang X, Sun M, Pang C, Qu J, Liu G, Li J. Reduced miR-200b and miR-200c expression contributes to abnormal hepatic lipid accumulation by stimulating JUN expression and activating the transcription of srebp1. Oncotarget. 2016; 7:36207–19. https://doi.org/10.18632/oncotarget.9183 [PubMed]