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Warning Text %XTableStyleMedium2PivotStyleLight16`, Table S3aD Table S3bT% Table S3cB 1 Table S3d 7 Table S3e?B Table S3f;L Table S3g\MTableS3hO Table S3iPTable3j 2!  ;!!  ;!!  ;%!  ;!5 =, UniProtIdsGenes ProteinNamesProteinDescriptionsValidComparison (group1/group2)Condition NumeratorCondition Denominator # of RatiosGroupAVG Group Quantity DenominatorAVG Group Quantity NumeratorAVG Log2 RatioAbsolute AVG Log2 Ratio% ChangeRatioEPRECATED] AVG Log2 Ratio$[DEPRECATED] Absolute AVG Log2 Ratio[DEPRECATED] % Change[DEPRECATED] RatioStandard DeviationPvalueQvalueDegrees Of FreedomStandard Error ProteinGroups OrganismsGO Biological ProcessGO Molecular FunctionGO Cellular ComponentDatabase OrganismIdProtein ExistenceSequence Version FASTAName FASTAHeader# Unique Total Peptides# Unique Total EG.IdO43747AP1G1 AP1G1_HUMANAP-1 complex subunit gamma-1IR / QuiescentIR Quiescent Homo sapiensqintracellular protein transport,antigen processing and presentation of exogenous peptide antigen via MHC class II,melanosome organization,endosome to melanosome transport,positive regulation of natural killer cell degranulation,positive regulation of natural killer cell mediated cytotoxicity,regulation of defense response to virus by virus,Golgi to lysosome transporttransporter activity,protein binding,protein transporter activity,Rab GTPase binding,kinesin binding,GTP-dependent protein bindingeGolgi membrane,cytoplasm,lysosomal membrane,Golgi apparatus,cytosol,membrane,AP-type membrane coat adaptor complex,clathrin adaptor complex,clathrin-coated vesicle,cytoplasmic vesicle membrane,clathrin-coated vesicle membrane,clathrin-coated endocytic vesicle membrane,trans-Golgi network membrane,intracellular membrane-bounded organelle,recycling endosomespHuman_Canonical_pSP_2021_0731^>sp|O43747|AP1G1_HUMAN AP-1 complex subunit gamma-1 OS=Homo sapiens OX=9606 GN=AP1G1 PE=1 SV=5Q9Y3E0GOLT1B GOT1B_HUMANVesicle transport protein GOT1B{signal transduction,protein transport,vesicle-mediated transport,positive regulation of I-kappaB kinase/NF-kappaB signalingsignal transducer activityLGolgi membrane,endoplasmic reticulum,membrane,integral component of membraneb>sp|Q9Y3E0|GOT1B_HUMAN Vesicle transport protein GOT1B OS=Homo sapiens OX=9606 GN=GOLT1B PE=1 SV=1O60784TOM1 TOM1_HUMANTarget of Myb protein 1jintracellular protein transport,endocytosis,protein transport,endosomal transport,neutrophil degranulation protein binding,clathrin bindingcytoplasm,endosome,early endosome,cytosol,plasma membrane,membrane,azurophil granule membrane,specific granule membrane,extracellular exosomeW>sp|O60784|TOM1_HUMAN Target of Myb protein 1 OS=Homo sapiens OX=9606 GN=TOM1 PE=1 SV=2Q9H4A4RNPEP AMPB_HUMANAminopeptidase BKproteolysis,peptide catabolic process,negative regulation of blood pressureaminopeptidase activity,epoxide hydrolase activity,metalloexopeptidase activity,zinc ion binding,peptide binding,metalloaminopeptidase activity`extracellular region,extracellular space,plasma membrane,secretory granule,extracellular exosomeQ>sp|Q9H4A4|AMPB_HUMAN Aminopeptidase B OS=Homo sapiens OX=9606 GN=RNPEP PE=1 SV=2P62820RAB1A RAB1A_HUMANRas-related protein Rab-1Aautophagosome assembly,ER to Golgi vesicle-mediated transport,retrograde vesicle-mediated transport, Golgi to ER,endocytosis,autophagy,Golgi organization,small GTPase mediated signal transduction,vesicle-mediated transport,cell migration,virion assembly,growth hormone secretion,melanosome transport,substrate adhesion-dependent cell spreading,defense response to bacterium,vesicle transport along microtubule,COPII vesicle coating,membrane organization,interleukin-8 secretion,cargo loading into COPII-coated vesicle,positive regulation of glycoprotein metabolic process,positive regulation of ubiquitin protein ligase activity,cilium morphogenesis,establishment of endothelial intestinal barrier<GTPase activity,protein binding,GTP binding,cadherin bindingGolgi membrane,early endosome,endoplasmic reticulum membrane,Golgi apparatus,cytosol,transport vesicle membrane,melanosome,extracellular exosome\>sp|P62820|RAB1A_HUMAN Ras-related protein Rab-1A OS=Homo sapiens OX=9606 GN=RAB1A PE=1 SV=3P12955PEPD PEPD_HUMANXaa-Pro dipeptidaseLproteolysis,cellular amino acid metabolic process,collagen catabolic process{aminopeptidase activity,metallocarboxypeptidase activity,protein binding,manganese ion binding,proline dipeptidase activityextracellular exosomeS>sp|P12955|PEPD_HUMAN Xaa-Pro dipeptidase OS=Homo sapiens OX=9606 GN=PEPD PE=1 SV=3Q9BZQ8NIBAN1 NIBA1_HUMANProtein Niban 1negative regulation of protein phosphorylation,positive regulation of protein phosphorylation,response to endoplasmic reticulum stress,positive regulation of translation"molecular_function,protein binding@cytoplasm,cytosol,plasma membrane,membrane,extracellular exosomeR>sp|Q9BZQ8|NIBA1_HUMAN Protein Niban 1 OS=Homo sapiens OX=9606 GN=NIBAN1 PE=1 SV=1P63208SKP1 SKP1_HUMAN#S-phase kinase-associated protein 1G2/M transition of mitotic cell cycle,protein polyubiquitination,stimulatory C-type lectin receptor signaling pathway,SCF complex assembly,negative regulation of G2/M transition of mitotic cell cycle,Wnt signaling pathway,protein ubiquitination,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process,histone H2A monoubiquitination,NIK/NF-kappaB signaling,Fc-epsilon receptor signaling pathway,proteasome-mediated ubiquitin-dependent protein catabolic process,T cell receptor signaling pathway,stress-activated MAPK cascade,positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition,maintenance of protein location in nucleusubiquitin-protein transferase activity,protein binding,beta-catenin binding,cullin family protein binding,ubiquitin protein ligase activitynucleus,nucleoplasm,cytoplasm,cytosol,SCF ubiquitin ligase complex,Cul7-RING ubiquitin ligase complex,extracellular exosome,PcG protein complexc>sp|P63208|SKP1_HUMAN S-phase kinase-associated protein 1 OS=Homo sapiens OX=9606 GN=SKP1 PE=1 SV=2Q92633LPAR1 LPAR1_HUMAN Lysophosphatidic acid receptor 17activation of MAPK activity,G-protein coupled receptor signaling pathway,adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway,activation of phospholipase C activity,positive regulation of cytosolic calcium ion concentration,regulation of cell shape,negative regulation of neuron projection development,oligodendrocyte development,cerebellum development,optic nerve development,corpus callosum development,negative regulation of cAMP biosynthetic process,bleb assembly,positive regulation of Rho protein signal transduction,myelination,positive regulation of apoptotic process,positive regulation of I-kappaB kinase/NF-kappaB signaling,positive regulation of MAPK cascade,positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway,positive regulation of stress fiber assembly,cell chemotaxis,positive regulation of dendritic spine development,cellular response to oxygen levels,positive regulation of smooth muscle cell chemotaxis,cellular response to 1-oleoyl-sn-glycerol 3-phosphateG-protein alpha-subunit binding,G-protein coupled receptor activity,protein binding,PDZ domain binding,lysophosphatidic acid binding,lysophosphatidic acid receptor activityendosome,plasma membrane,integral component of plasma membrane,cell surface,neuronal cell body,dendritic spine,dendritic shaft,endocytic vesicleb>sp|Q92633|LPAR1_HUMAN Lysophosphatidic acid receptor 1 OS=Homo sapiens OX=9606 GN=LPAR1 PE=1 SV=3P50148GNAQ GNAQ_HUMAN5Guanine nucleotide-binding protein G(q) subunit alphaskeletal system development,action potential,negative regulation of protein kinase activity,adenylate cyclase-activating G-protein coupled receptor signaling pathway,activation of phospholipase C activity,G-protein coupled acetylcholine receptor signaling pathway,glutamate receptor signaling pathway,heart development,blood coagulation,phototransduction, visible light,entrainment of circadian clock,post-embryonic development,neuron remodel< ing,forebrain neuron development,platelet activation,regulation of catenin import into nucleus,maternal behavior,embryonic digit morphogenesis,positive regulation of GTPase activity,regulation of melanocyte differentiation,developmental pigmentation,protein stabilization,phospholipase C-activating dopamine receptor signaling pathwayGTPase activity,signal transducer activity,GTPase activator activity,protein binding,GTP binding,G-protein beta/gamma-subunit complex binding,type 2A serotonin receptor binding,metal ion bindingphotoreceptor outer segment,cytoplasm,lysosomal membrane,heterotrimeric G-protein complex,plasma membrane,dendrite,nuclear membrane,cell body,extracellular exosomeu>sp|P50148|GNAQ_HUMAN Guanine nucleotide-binding protein G(q) subunit alpha OS=Homo sapiens OX=9606 GN=GNAQ PE=1 SV=4Q14574DSC3 DSC3_HUMAN Desmocollin-3in utero embryonic development,cell adhesion,homophilic cell adhesion via plasma membrane adhesion molecules,keratinization,cornificationcalcium ion bindingcornified envelope,extracellular region,cytoplasm,plasma membrane,cell-cell junction,membrane,integral component of membrane,cell junction,desmosomeM>sp|Q14574|DSC3_HUMAN Desmocollin-3 OS=Homo sapiens OX=9606 GN=DSC3 PE=1 SV=3O43681GET3 GET3_HUMAN ATPase GET3Ktransport,inorganic anion transport,IRE1-mediated unfolded protein responsetransporter activity,protein binding,ATP binding,arsenite transmembrane transporter activity,ATPase activity, coupled to movement of substances,metal ion bindingPnucleus,nucleolus,cytoplasm,endoplasmic reticulum membrane,extracellular exosomeK>sp|O43681|GET3_HUMAN ATPase GET3 OS=Homo sapiens OX=9606 GN=GET3 PE=1 SV=2Q9HCL0PCDH18 PCD18_HUMANProtocadherin-18cell adhesion,homophilic cell adhesion via plasma membrane adhesion molecules,cell-cell signaling,nervous system development,brain development%integral component of plasma membraneS>sp|Q9HCL0|PCD18_HUMAN Protocadherin-18 OS=Homo sapiens OX=9606 GN=PCDH18 PE=1 SV=3P62330ARF6 ARF6_HUMANADP-ribosylation factor 6liver development,movement of cell or subcellular component,cell cycle,cell adhesion,small GTPase mediated signal transduction,protein transport,vesicle-mediated transport,positive regulation of actin filament polymerization,cortical actin cytoskeleton organization,ruffle organization,myeloid cell apoptotic process,protein localization to cell surface,regulation of Rac protein signal transduction,protein localization to endosome,negative regulation of receptor-mediated endocytosis,cell division,regulation of filopodium assembly,regulation of dendritic spine development,membrane organization,positive regulation of establishment of protein localization to plasma membrane,establishment of epithelial cell polarity,hepatocyte apoptotic process,negative regulation of dendrite development[GTPase activity,protein binding,GTP binding,thioesterase binding,protein N-terminus bindingruffle,endosome,early endosome,Golgi apparatus,plasma membrane,focal adhesion,cell cortex,membrane,endocytic vesicle,midbody,filopodium membrane,cleavage furrow,myelin sheath,recycling endosome membrane,extracellular exosomeY>sp|P62330|ARF6_HUMAN ADP-ribosylation factor 6 OS=Homo sapiens OX=9606 GN=ARF6 PE=1 SV=2P24390KDELR1 ERD21_HUMAN%ER lumen protein-retaining receptor 1T cell cytokine production,protein retention in ER lumen,intracellular protein transport,ER to Golgi vesicle-mediated transport,retrograde vesicle-mediated transport, Golgi to ER,T cell differentiation,T cell apoptotic processKDEL sequence binding Golgi membrane,endoplasmic reticulum membrane,endoplasmic reticulum-Golgi intermediate compartment,cis-Golgi network,membrane,integral component of membrane,transport vesicle,COPI-coated vesicle membrane,endoplasmic reticulum-Golgi intermediate compartment membraneh>sp|P24390|ERD21_HUMAN ER lumen protein-retaining receptor 1 OS=Homo sapiens OX=9606 GN=KDELR1 PE=1 SV=1O75223GGCT GGCT_HUMANGamma-glutamylcyclotransferaseJrelease of cytochrome c from mitochondria,glutathione biosynthetic processIgamma-glutamylcyclotransferase activity,protein homodimerization activitycytosol,extracellular exosome^>sp|O75223|GGCT_HUMAN Gamma-glutamylcyclotransferase OS=Homo sapiens OX=9606 GN=GGCT PE=1 SV=1P43007SLC1A4 SATT_HUMAN Neutral amino acid transporter Aamino acid transport,glutamine transport,L-alanine transport,L-cystine transport,proline transport,L-serine transport,threonine transport,hydroxyproline transport,synaptic transmission, glutamatergic,proline transmembrane transport,cognition,chloride transmembrane transportchloride channel activity,amino acid transmembrane transporter activity,L-alanine transmembrane transporter activity,L-cystine transmembrane transporter activity,L-glutamine transmembrane transporter activity,L-proline transmembrane transporter activity,L-serine transmembrane transporter activity,L-threonine transmembrane transporter activity,symporter activity,L-hydroxyproline transmembrane transporter activityintermediate filament,plasma membrane,integral component of plasma membrane,cell surface,membrane,integral component of membrane,dendrite,melanosome,neuronal cell body,extracellular exosomeb>sp|P43007|SATT_HUMAN Neutral amino acid transporter A OS=Homo sapiens OX=9606 GN=SLC1A4 PE=1 SV=1P04156PRNP PRIO_HUMANMajor prion protein6negative regulation of protein phosphorylation,cellular copper ion homeostasis,response to oxidative stress,cell cycle arrest,signal transduction,long-term memory,metabolic process,negative regulation of interferon-gamma production,negative regulation of interleukin-17 production,negative regulation of interleukin-2 production,cellular response to drug,negative regulation of apoptotic process,negative regulation of sequence-specific DNA binding transcription factor activity,negative regulation of activated T cell proliferation,response to cadmium ion,positive regulation of peptidyl-tyrosine phosphorylation,negative regulation of T cell receptor signaling pathway,protein homooligomerization,negative regulation of calcineurin-NFAT signaling cascade,cellular response to copper ion,positive regulation of protein targeting to membrane,negative regulation of long-term synaptic potentiation,positive regulation of neuron death,regulation of potassium ion transmembrane transport,negative regulation of dendritic spine maintenance,response to beta-amyloid,Requires Ontologybeta-amyloid binding,signal transducer activity,receptor activity,copper ion binding,protein binding,lamin binding,microtubule binding,tubulin binding,identical protein binding,ATP-dependent protein binding,ion channel binding,chaperone bindingcytoplasm,endoplasmic reticulum,Golgi apparatus,cytosol,plasma membrane,cell surface,postsynaptic density,extrinsic component of membrane,dendrite,anchored component of membrane,nuclear membrane,intracellular membrane-bounded organelle,membrane raft,extracellular exosomeS>sp|P04156|PRIO_HUMAN Major prion protein OS=Homo sapiens OX=9606 GN=PRNP PE=1 SV=1Q9NZH0GPRC5B GPC5B_HUMAN4G-protein coupled receptor family C group 5 member BG-protein coupled receptor signaling pathway,locomotory behavior,positive regulation of neuron projection development,activation of protein kinase activity,glucose homeostasis,positive regulation of I-kappaB kinase/NF-kappaB signaling,positive regulation of neuron differentiation,positive regulation of inflammatory response,positive regulation of macrophage cytokine production,positive regulation of protein tyrosine kinase activity,positive regulation of canonical Wnt signaling pathwayG-protein coupled receptor binding,G-protein coupled receptor activity,protein kinase binding,protein kinase activator activityextracellular space,nucleus,nucleolus,cytosol,plasma membrane,cell surface,integral component of membrane,cytoplasmic vesicle membrane,intracellular membrane-bounded organelle,membrane raft,extracellular exosomew>sp|Q9NZH0|GPC5B_HUMAN G-protein coupled receptor family C group 5 member B OS=Homo sapiens OX=9606 GN=GPRC5B PE=2 SV=2P05452CLEC3B TETN_HUMAN Tetranectin< ossification,platelet degranulation,positive regulation of plasminogen activation,bone mineralization,cellular response to organic substance,cellular response to transforming growth factor beta stimulusOcalcium ion binding,heparin binding,carbohydrate binding,kringle domain bindinggranular component,extracellular region,extracellular space,cytoplasm,platelet dense granule lumen,extracellular exosome,extracellular matrixM>sp|P05452|TETN_HUMAN Tetranectin OS=Homo sapiens OX=9606 GN=CLEC3B PE=1 SV=3P53004BLVRA BIEA_HUMANBiliverdin reductase A2heme catabolic process,oxidation-reduction process>biliverdin reductase activity,protein binding,zinc ion bindingW>sp|P53004|BIEA_HUMAN Biliverdin reductase A OS=Homo sapiens OX=9606 GN=BLVRA PE=1 SV=2Q9UNS2COPS3 CSN3_HUMAN"COP9 signalosome complex subunit 3protein deneddylation,nucleotide-excision repair, DNA damage recognition,in utero embryonic development,transcription-coupled nucleotide-excision repair,ubiquitin-dependent protein catabolic process,signal transduction,response to light stimulusprotein binding6nucleus,nucleoplasm,cytoplasm,cytosol,COP9 signalosomec>sp|Q9UNS2|CSN3_HUMAN COP9 signalosome complex subunit 3 OS=Homo sapiens OX=9606 GN=COPS3 PE=1 SV=3P21283ATP6V1C1 VATC1_HUMAN V-type proton ATPase subunit C 1insulin receptor signaling pathway,ATP hydrolysis coupled proton transport,proton transport,regulation of macroautophagy,transferrin transport,ion transmembrane transport,phagosome acidificationtransporter activity,protein binding,hydrogen-exporting ATPase activity, phosphorylative mechanism,proton-transporting ATPase activity, rotational mechanismvacuolar proton-transporting V-type ATPase, V1 domain,lysosomal membrane,cytosol,plasma membrane,proton-transporting two-sector ATPase complex,cytoplasmic vesicle,apical part of cell,extracellular exosomee>sp|P21283|VATC1_HUMAN V-type proton ATPase subunit C 1 OS=Homo sapiens OX=9606 GN=ATP6V1C1 PE=1 SV=4P62899RPL31 RL31_HUMAN60S ribosomal protein L31nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,viral transcription>RNA binding,structural constituent of ribosome,protein bindingWcytosol,focal adhesion,membrane,cytosolic large ribosomal subunit,extracellular exosomeZ>sp|P62899|RL31_HUMAN 60S ribosomal protein L31 OS=Homo sapiens OX=9606 GN=RPL31 PE=1 SV=1O95297MPZL1 MPZL1_HUMAN"Myelin protein zero-like protein 1Ttransmembrane receptor protein tyrosine kinase signaling pathway,cell-cell signaling,structural molecule activity,protein bindingAintegral component of plasma membrane,focal adhesion,cell surfaced>sp|O95297|MPZL1_HUMAN Myelin protein zero-like protein 1 OS=Homo sapiens OX=9606 GN=MPZL1 PE=1 SV=1Q8IUE6H2AC21 H2A2B_HUMANHistone H2A type 2-B&chromatin silencing,biological_processBmolecular_function,DNA binding,protein heterodimerization activity:nucleosome,nuclear chromatin,nucleus,extracellular exosomeW>sp|Q8IUE6|H2A2B_HUMAN Histone H2A type 2-B OS=Homo sapiens OX=9606 GN=H2AC21 PE=1 SV=3Q05682CALD1 CALD1_HUMAN Caldesmon<movement of cell or subcellular component,muscle contractiondactin binding,protein binding,calmodulin binding,tropomyosin binding,myosin binding,cadherin bindingtcytosol,cytoskeleton,plasma membrane,actin cytoskeleton,myofibril,actin cap,intracellular membrane-bounded organelleK>sp|Q05682|CALD1_HUMAN Caldesmon OS=Homo sapiens OX=9606 GN=CALD1 PE=1 SV=3P98172EFNB1 EFNB1_HUMAN Ephrin-B1neural crest cell migration,cell adhesion,cell-cell signaling,axon guidance,embryonic pattern specification,T cell costimulation,positive regulation of T cell proliferation,ephrin receptor signaling pathway'protein binding,ephrin receptor bindingsnucleus,cytoplasm,plasma membrane,integral component of plasma membrane,membrane raft,synapse,extracellular exosomeK>sp|P98172|EFNB1_HUMAN Ephrin-B1 OS=Homo sapiens OX=9606 GN=EFNB1 PE=1 SV=1P80303NUCB2 NUCB2_HUMANNucleobindin-2/DNA binding,calcium ion binding,protein bindingextracellular space,nuclear envelope,endoplasmic reticulum,endoplasmic reticulum-Golgi intermediate compartment,Golgi apparatus,cytosol,plasma membrane,extracellular exosomeP>sp|P80303|NUCB2_HUMAN Nucleobindin-2 OS=Homo sapiens OX=9606 GN=NUCB2 PE=1 SV=3P01266TG THYG_HUMAN Thyroglobulinsignal transduction,iodide transport,thyroid gland development,regulation of myelination,thyroid hormone metabolic process,hormone biosynthetic processhormone activityextracellular regionK>sp|P01266|THYG_HUMAN Thyroglobulin OS=Homo sapiens OX=9606 GN=TG PE=1 SV=5P05386RPLP1 RLA1_HUMAN60S acidic ribosomal protein P1Nnuclear-transcribed mRNA catabolic process, nonsense-mediated decay,cytoplasmic translation,rRNA processing,translation,translational initiation,translational elongation,SRP-dependent cotranslational protein targeting to membrane,viral transcription,activation of protein kinase activity,positive regulation of protein kinase activityTstructural constituent of ribosome,protein binding,protein kinase activator activityNcytosol,focal adhesion,cytosolic large ribosomal subunit,extracellular exosome`>sp|P05386|RLA1_HUMAN 60S acidic ribosomal protein P1 OS=Homo sapiens OX=9606 GN=RPLP1 PE=1 SV=1 P0C0S5;Q71UI9 H2AZ1;H2AZ2H2AZ_HUMAN;H2AV_HUMANHistone H2A.Z;Histone H2A.Vchromatin silencing,positive regulation of transcription from RNA polymerase II promoter,cellular response to estradiol stimulus;chromatin silencing,biological_processpRNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II core promoter sequence-specific DNA binding,RNA polymerase II distal enhancer sequence-specific DNA binding,protein binding,chromatin DNA binding,nucleosomal DNA binding,protein heterodimerization activity;molecular_function,DNA binding,protein heterodimerization activitynucleosome,nucleus,nuclear euchromatin,nuclear heterochromatin,extracellular exosome,Barr body;nucleosome,nuclear chromatin,nucleus,extracellular exosome2;3>sp|P0C0S5|H2AZ_HUMAN Histone H2A.Z OS=Homo sapiens OX=9606 GN=H2AZ1 PE=1 SV=2;>sp|Q71UI9|H2AV_HUMAN Histone H2A.V OS=Homo sapiens OX=9606 GN=H2AZ2 PE=1 SV=3P10155RO60 RO60_HUMAN 60 kDa SS-A/Ro ribonucleoproteinimmune system development,transcription from RNA polymerase III promoter,smoothened signaling pathway,response to UV,cilium morphogenesis.RNA binding,U2 snRNA binding,metal ion binding;nucleoplasm,cytosol,intracellular ribonucleoprotein complex`>sp|P10155|RO60_HUMAN 60 kDa SS-A/Ro ribonucleoprotein OS=Homo sapiens OX=9606 GN=RO60 PE=1 SV=2O75533SF3B1 SF3B1_HUMANSplicing factor 3B subunit 1spliceosomal complex assembly,RNA splicing, via transesterification reactions,mRNA splicing, via spliceosome,positive regulation of gene expression, epigenetic(RNA binding,mRNA binding,protein bindingnucleus,nucleoplasm,spliceosomal complex,U2 snRNP,U12-type spliceosomal complex,nuclear speck,U11/U12 snRNP,U2-type prespliceosome,catalytic step 2 spliceosome^>sp|O75533|SF3B1_HUMAN Splicing factor 3B subunit 1 OS=Homo sapiens OX=9606 GN=SF3B1 PE=1 SV=3P24844MYL9 MYL9_HUMAN%Myosin regulatory light polypeptide 9Hmuscle contraction,regulation of muscle contraction,platelet aggregationOcalcium ion binding,structural constituent of muscle,myosin heavy chain binding1stress fiber,cytosol,muscle myosin complex,Z disce>sp|P24844|MYL9_HUMAN Myosin regulatory light polypeptide 9 OS=Homo sapiens OX=9606 GN=MYL9 PE=1 SV=4Q9NRV9HEBP1 HEBP1_HUMANHeme-binding protein 1circadian rhythm heme binding4extracellular region,cytoplasm,extracellular exosomeX>sp|Q9NRV9|HEBP1_HUMAN Heme-binding protein 1 OS=Homo sapiens OX=9606 GN=HEBP1 PE=1 SV=1Q9UK41VPS28 VPS28_HUMAN6Vacuolar protein sorting-associated protein 28 homolog endosomal transport,macroautophagy,viral life cycle,negative regulation of protein ubiquitination,multivesicular body assembly,viral budding via host ESCRT complex,ubiquitin-dependent protei< n catabolic process via the multivesicular body sorting pathway,protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway,positive regulation of protein catabolic process,intracellular transport of virus,positive regulation of ubiquitin-dependent endocytosis9protein binding,protein complex binding,ubiquitin bindingESCRT I complex,cytoplasm,endosome,early endosome,cytosol,plasma membrane,endosome membrane,late endosome membrane,extracellular exosomex>sp|Q9UK41|VPS28_HUMAN Vacuolar protein sorting-associated protein 28 homolog OS=Homo sapiens OX=9606 GN=VPS28 PE=1 SV=1P34059GALNS GALNS_HUMAN!N-acetylgalactosamine-6-sulfatase:keratan sulfate catabolic process,neutrophil degranulationN-acetylgalactosamine-4-sulfatase activity,sulfuric ester hydrolase activity,N-acetylgalactosamine-6-sulfatase activity,metal ion bindingRextracellular region,azurophil granule lumen,lysosomal lumen,extracellular exosomec>sp|P34059|GALNS_HUMAN N-acetylgalactosamine-6-sulfatase OS=Homo sapiens OX=9606 GN=GALNS PE=1 SV=1P42357HAL HUTH_HUMANHistidine ammonia-lyasehistidine catabolic process,histidine catabolic process to glutamate and formamide,histidine catabolic process to glutamate and formate histidine ammonia-lyase activitycytosolV>sp|P42357|HUTH_HUMAN Histidine ammonia-lyase OS=Homo sapiens OX=9606 GN=HAL PE=1 SV=1P54803GALC GALC_HUMANGalactocerebrosidasegcarbohydrate metabolic process,galactosylceramide catabolic process,glycosphingolipid metabolic processgalactosylceramidase activity<mitochondrion,lysosome,lysosomal lumen,extracellular exosomeT>sp|P54803|GALC_HUMAN Galactocerebrosidase OS=Homo sapiens OX=9606 GN=GALC PE=1 SV=3P50502ST13 F10A1_HUMANHsc70-interacting proteinprotein folding,protein homooligomerization,negative regulation of protein refolding,chaperone cofactor-dependent protein refoldingprotein binding,protein domain specific binding,Hsp70 protein binding,protein binding, bridging,protein complex binding,dATP binding,identical protein binding,unfolded protein binding,chaperone binding7cytoplasm,cytosol,protein complex,extracellular exosomeZ>sp|P50502|F10A1_HUMAN Hsc70-interacting protein OS=Homo sapiens OX=9606 GN=ST13 PE=1 SV=2Q9HCE7SMURF1 SMUF1_HUMAN"E3 ubiquitin-protein ligase SMURF1#protein polyubiquitination,protein export from nucleus,transforming growth factor beta receptor signaling pathway,ectoderm development,protein ubiquitination,cell differentiation,negative regulation of ossification,BMP signaling pathway,negative regulation of transforming growth factor beta receptor signaling pathway,negative regulation of BMP signaling pathway,ubiquitin-dependent SMAD protein catabolic process,receptor catabolic process,protein localization to cell surface,protein ubiquitination involved in ubiquitin-dependent protein catabolic process,proteasome-mediated ubiquitin-dependent protein catabolic process,Wnt signaling pathway, planar cell polarity pathway,parkin-mediated mitophagy in response to mitochondrial depolarization,engulfment of target by autophagosome,substrate localization to autophagosome,protein targeting to vacuole involved in autophagy,protein targeting to plasma membrane,positive regulation of dendrite extension,positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processubiquitin-protein transferase activity,protein binding,phospholipid binding,activin binding,ubiquitin protein ligase activity,I-SMAD binding,R-SMAD bindinginucleoplasm,cytoplasm,cytosol,plasma membrane,axon,neuronal cell body,extracellular exosome,mitochondrione>sp|Q9HCE7|SMUF1_HUMAN E3 ubiquitin-protein ligase SMURF1 OS=Homo sapiens OX=9606 GN=SMURF1 PE=1 SV=2P54578USP14 UBP14_HUMAN(Ubiquitin carboxyl-terminal hydrolase 143ubiquitin-dependent protein catabolic process,chemical synaptic transmission,negative regulation of endopeptidase activity,protein deubiquitination,regulation of chemotaxis,regulation of proteasomal protein catabolic process,negative regulation of ER-associated ubiquitin-dependent protein catabolic processcysteine-type endopeptidase activity,thiol-dependent ubiquitin-specific protease activity,endopeptidase inhibitor activity,protein binding,tRNA guanylyltransferase activity,proteasome bindingiproteasome complex,cytosol,plasma membrane,cell surface,cytoplasmic vesicle,synapse,extracellular exosomej>sp|P54578|UBP14_HUMAN Ubiquitin carboxyl-terminal hydrolase 14 OS=Homo sapiens OX=9606 GN=USP14 PE=1 SV=3Q15323KRT31 K1H1_HUMANKeratin, type I cuticular Ha1Lcytoskeleton organization,epidermis development,keratinization,cornification6structural constituent of cytoskeleton,protein bindingGextracellular space,cytosol,intermediate filament,extracellular exosome^>sp|Q15323|K1H1_HUMAN Keratin, type I cuticular Ha1 OS=Homo sapiens OX=9606 GN=KRT31 PE=1 SV=3Q00765REEP5 REEP5_HUMAN'Receptor expression-enhancing protein 5biological_processZintegral component of membrane,extracellular exosome,endoplasmic reticulum tubular networki>sp|Q00765|REEP5_HUMAN Receptor expression-enhancing protein 5 OS=Homo sapiens OX=9606 GN=REEP5 PE=1 SV=3P51812RPS6KA3 KS6A3_HUMAN#Ribosomal protein S6 kinase alpha-3|skeletal system development,toll-like receptor signaling pathway,apoptotic process,cell cycle,signal transduction,central nervous system development,peptidyl-serine phosphorylation,positive regulation of cell growth,response to lipopolysaccharide,intracellular signal transduction,negative regulation of apoptotic process,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process,regulation of translation in response to stress,regulation of DNA-templated transcription in response to stress,positive regulation of cell differentiation,positive regulation of transcription from RNA polymerase II promotermagnesium ion binding,protein kinase activity,protein serine/threonine kinase activity,protein binding,ATP binding,kinase activity,protein kinase binding,cysteine-type endopeptidase inhibitor activity involved in apoptotic process%nucleus,nucleoplasm,cytoplasm,cytosolg>sp|P51812|KS6A3_HUMAN Ribosomal protein S6 kinase alpha-3 OS=Homo sapiens OX=9606 GN=RPS6KA3 PE=1 SV=1Q9NYU2UGGT1 UGGG1_HUMAN.UDP-glucose:glycoprotein glucosyltransferase 1zprotein glycosylation,'de novo' posttranslational protein folding,UDP-glucosylation,endoplasmic reticulum mannose trimming^UDP-glucose:glycoprotein glucosyltransferase activity,protein binding,unfolded protein bindingendoplasmic reticulum,endoplasmic reticulum lumen,endoplasmic reticulum-Golgi intermediate compartment,endoplasmic reticulum quality control compartment,extracellular exosomep>sp|Q9NYU2|UGGG1_HUMAN UDP-glucose:glycoprotein glucosyltransferase 1 OS=Homo sapiens OX=9606 GN=UGGT1 PE=1 SV=3P51809VAMP7 VAMP7_HUMAN%Vesicle-associated membrane protein 7ER to Golgi vesicle-mediated transport,post-Golgi vesicle-mediated transport,endocytosis,vesicle fusion,phagocytosis, engulfment,endosome to lysosome transport,vesicle-mediated transport,calcium ion regulated exocytosis,triglyceride transport,SNARE complex assembly,Golgi to plasma membrane protein transport,eosinophil degranulation,neutrophil degranulation,natural killer cell degranulation,vesicle transport along microtubule,vesicle fusion with Golgi apparatus,positive regulation of dendrite morphogenesis,membrane organization,regulation of protein targeting to vacuolar membrane,positive regulation of histamine secretion by mast cell,autophagosome maturationESNARE binding,SNAP receptor activity,protein binding,syntaxin binding'cytoplasm,lysosomal membrane,endoplasmic reticulum membrane,trans-Golgi network,plasma membrane,cell surface,membrane,lamellipodium,cell junction,secretory granule,integral component of synaptic vesicle membrane,clathrin-coated vesicle membrane,secretory granule membrane,phagocytic vesicle membrane,platelet alpha granule,pseudopodium,SNARE complex,late endosome membrane,azurophil granule membrane,neuron projection,intracellular membrane-bou< nded organelle,apical part of cell,phagocytic vesicle,perinuclear region of cytoplasm,extracellular exosomeg>sp|P51809|VAMP7_HUMAN Vesicle-associated membrane protein 7 OS=Homo sapiens OX=9606 GN=VAMP7 PE=1 SV=3Q9H0E2TOLLIP TOLIP_HUMANToll-interacting proteinXubiquitin-dependent protein catabolic process,autophagy,inflammatory response,signal transduction,cell-cell signaling,phosphorylation,epithelial cell differentiation,positive regulation of protein sumoylation,intracellular signal transduction,protein localization to endosome,neutrophil degranulation,innate immune response,leukocyte activationsignal transducer activity,interleukin-1, Type I receptor binding,protein binding,kinase binding,ubiquitin conjugating enzyme binding,ubiquitin protein ligase binding,SUMO binding,Toll-like receptor binding,ubiquitin bindingextracellular region,cytoplasm,cytosol,nuclear body,azurophil granule lumen,specific granule lumen,interleukin-18 receptor complex,interleukin-1 receptor complex,perinuclear region of cytoplasm,extracellular exosome[>sp|Q9H0E2|TOLIP_HUMAN Toll-interacting protein OS=Homo sapiens OX=9606 GN=TOLLIP PE=1 SV=1P20340RAB6A RAB6A_HUMANRas-related protein Rab-6Ayprotein targeting to Golgi,retrograde vesicle-mediated transport, Golgi to ER,small GTPase mediated signal transduction,viral process,peptidyl-cysteine methylation,antigen processing and presentation,protein localization to Golgi apparatus,early endosome to Golgi transport,neutrophil degranulation,membrane organization,minus-end-directed organelle transport along microtubule\GTPase activity,protein binding,GTP binding,protein domain specific binding,myosin V bindingGolgi membrane,endoplasmic reticulum membrane,Golgi apparatus,trans-Golgi network,cytosol,plasma membrane,membrane,secretory granule membrane,cytoplasmic vesicle,trans-Golgi network membrane,extracellular exosome,endosome to plasma membrane transport vesicle\>sp|P20340|RAB6A_HUMAN Ras-related protein Rab-6A OS=Homo sapiens OX=9606 GN=RAB6A PE=1 SV=3O15162PLSCR1 PLS1_HUMANPhospholipid scramblase 1Ptranscription from RNA polymerase II promoter,phosphatidylserine biosynthetic process,apoptotic process,acute-phase response,positive regulation of gene expression,phospholipid scrambling,platelet activation,regulation of mast cell activation,response to interferon-beta,negative regulation of viral genome replication,positive regulation of innate immune response,positive regulation of transcription from RNA polymerase II promoter,defense response to virus,regulation of Fc receptor mediated stimulatory signaling pathway,positive regulation of DNA topoisomerase (ATP-hydrolyzing) activitytranscriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding,DNA binding,epidermal growth factor receptor binding,calcium ion binding,protein binding,SH3 domain binding,phospholipid scramblase activity,enzyme binding,CD4 receptor bindingnucleus,nucleolus,Golgi apparatus,cytosol,plasma membrane,integral component of plasma membrane,membrane,extracellular matrix,membrane raft,extracellular exosome[>sp|O15162|PLS1_HUMAN Phospholipid scramblase 1 OS=Homo sapiens OX=9606 GN=PLSCR1 PE=1 SV=1P12277CKB KCRB_HUMANCreatine kinase B-typecreatine metabolic process,phosphorylation,cerebellum development,substantia nigra development,cellular chloride ion homeostasisUcreatine kinase activity,protein binding,ATP binding,ubiquitin protein ligase bindingqextracellular space,nucleus,mitochondrion,cytosol,dendrite,neuronal cell body,myelin sheath,extracellular exosomeU>sp|P12277|KCRB_HUMAN Creatine kinase B-type OS=Homo sapiens OX=9606 GN=CKB PE=1 SV=1P49006MARCKSL1 MRP_HUMANMARCKS-related protein)positive regulation of cell proliferation0actin binding,protein binding,calmodulin binding/cytoplasm,plasma membrane,extracellular exosomeY>sp|P49006|MRP_HUMAN MARCKS-related protein OS=Homo sapiens OX=9606 GN=MARCKSL1 PE=1 SV=2Q9GZS3WDR61 WDR61_HUMANWD repeat-containing protein 61@transcription from RNA polymerase II promoter,transcription elongation from RNA polymerase II promoter,Wnt signaling pathway,protein ubiquitination,positive regulation of transcription elongation from RNA polymerase II promoter,exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay,negative regulation of myeloid cell differentiation,positive regulation of transcription from RNA polymerase II promoter,positive regulation of histone H3-K4 methylation,histone H3-K4 trimethylation,positive regulation of histone H3-K79 methylationgnucleus,nucleoplasm,cytoplasm,cytosol,Cdc73/Paf1 complex,transcriptionally active chromatin,Ski complexa>sp|Q9GZS3|WDR61_HUMAN WD repeat-containing protein 61 OS=Homo sapiens OX=9606 GN=WDR61 PE=1 SV=1O43390HNRNPR HNRPR_HUMAN)Heterogeneous nuclear ribonucleoprotein RmRNA splicing, via spliceosome,mRNA processing,circadian rhythm,gene expression,negative regulation of catalytic activity,positive regulation of mRNA catabolic process,mRNA destabilizationBnucleotide binding,RNA binding,mRNA 3'-UTR binding,protein bindingnucleoplasm,spliceosomal complex,endoplasmic reticulum,dendrite,growth cone,intracellular ribonucleoprotein complex,axon terminus,catalytic step 2 spliceosome,nucleolusl>sp|O43390|HNRPR_HUMAN Heterogeneous nuclear ribonucleoprotein R OS=Homo sapiens OX=9606 GN=HNRNPR PE=1 SV=1Q9Y6M1IGF2BP2 IF2B2_HUMAN3Insulin-like growth factor 2 mRNA-binding protein 2anatomical structure morphogenesis,gene expression,negative regulation of translation,regulation of cytokine biosynthetic process,mRNA transportunucleotide binding,RNA binding,mRNA 3'-UTR binding,protein binding,translation regulator activity,mRNA 5'-UTR binding&nucleus,cytoplasm,cytosol,cytoskeletonw>sp|Q9Y6M1|IF2B2_HUMAN Insulin-like growth factor 2 mRNA-binding protein 2 OS=Homo sapiens OX=9606 GN=IGF2BP2 PE=1 SV=2P53801PTTG1IP PTTG_HUMAN?Pituitary tumor-transforming gene 1 protein-interacting protein,protein import into nucleus,positive regulation of protein ubiquitination,negative regulation of DNA damage response, signal transduction by p53 class mediator,negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator,positive regulation of cellular protein catabolic process.p53 binding,molecular_function,protein binding[nucleus,nucleoplasm,cytoplasm,membrane,integral component of membrane,extracellular exosome>sp|P53801|PTTG_HUMAN Pituitary tumor-transforming gene 1 protein-interacting protein OS=Homo sapiens OX=9606 GN=PTTG1IP PE=1 SV=1Q9UPT5EXOC7 EXOC7_HUMANExocyst complex component 7iexocytosis,protein transport,regulation of macroautophagy,regulation of entry of bacterium into host cellpexocyst,microtubule organizing center,cytosol,plasma membrane,membrane,growth cone membrane,centriolar satellite]>sp|Q9UPT5|EXOC7_HUMAN Exocyst complex component 7 OS=Homo sapiens OX=9606 GN=EXOC7 PE=1 SV=3Q9H4G4GLIPR2 GAPR1_HUMAN5Golgi-associated plant pathogenesis-related protein 1positive regulation of epithelial cell migration,positive regulation of epithelial to mesenchymal transition,positive regulation of ERK1 and ERK2 cascade!protein homodimerization activity$Golgi membrane,extracellular exosomex>sp|Q9H4G4|GAPR1_HUMAN Golgi-associated plant pathogenesis-related protein 1 OS=Homo sapiens OX=9606 GN=GLIPR2 PE=1 SV=3P42785PRCP PCP_HUMAN Lysosomal Pro-X carboxypeptidaseregulation of thyroid hormone mediated signaling pathway,plasma kallikrein-kinin cascade,negative regulation of systemic arterial blood pressure,proteolysis,blood coagulation, intrinsic pathway,glucose homeostasis,neutrophil degranulation,regulation of blood vessel endothelial cell migration,angiogenesis involved in wound healing,energy homeostasis,regulation of reactive oxygen species metabolic process5serine-type carboxypeptidase activity,protein bindingsplasma membrane,azurophil granule membrane,basal part of cell,extracellular exosome,ficolin-1-rich granule membrane_>sp|P42785|PCP_HUMAN Lysosomal Pro-X carboxypeptidase OS=Homo sapiens < OX=9606 GN=PRCP PE=1 SV=1P35611ADD1 ADDA_HUMAN Alpha-adducincell morphogenesis,in utero embryonic development,cell volume homeostasis,hemoglobin metabolic process,actin cytoskeleton organization,erythrocyte differentiation,positive regulation of protein binding,multicellular organism growth,IRE1-mediated unfolded protein response,homeostasis of number of cells within a tissue,barbed-end actin filament capping,actin filament bundle assembly,transmembrane transportRNA binding,actin binding,structural molecule activity,calmodulin binding,transcription factor binding,spectrin binding,protein homodimerization activity,cadherin binding,protein heterodimerization activity,actin filament bindinggnucleus,nucleoplasm,cytosol,plasma membrane,focal adhesion,F-actin capping protein complex,nuclear bodyM>sp|P35611|ADDA_HUMAN Alpha-adducin OS=Homo sapiens OX=9606 GN=ADD1 PE=1 SV=2Q9BXP2SLC12A9 S12A9_HUMAN!Solute carrier family 12 member 9Fpotassium ion transmembrane transport,chloride transmembrane transportication:chloride symporter activity,potassium:chloride symporter activity,potassium ion symporter activityDplasma membrane,integral component of membrane,extracellular exosomee>sp|Q9BXP2|S12A9_HUMAN Solute carrier family 12 member 9 OS=Homo sapiens OX=9606 GN=SLC12A9 PE=1 SV=1Q9Y6E0STK24 STK24_HUMAN"Serine/threonine-protein kinase 24=protein phosphorylation,signal transduction,intrinsic apoptotic signaling pathway in response to oxidative stress,signal transduction by protein phosphorylation,negative regulation of cell migration,response to hydrogen peroxide,protein autophosphorylation,regulation of axon regeneration,execution phase of apoptosisprotein kinase activity,protein serine/threonine kinase activity,receptor signaling protein serine/threonine kinase activity,protein binding,ATP binding,cadherin binding,metal ion bindingNnucleus,nucleoplasm,nucleolus,cytoplasm,cytosol,membrane,extracellular exosomed>sp|Q9Y6E0|STK24_HUMAN Serine/threonine-protein kinase 24 OS=Homo sapiens OX=9606 GN=STK24 PE=1 SV=1P61026RAB10 RAB10_HUMANRas-related protein Rab-10Golgi to plasma membrane transport,vesicle docking involved in exocytosis,small GTPase mediated signal transduction,axonogenesis,protein secretion,vesicle-mediated transport,endosomal transport,antigen processing and presentation,polarized epithelial cell differentiation,cellular response to insulin stimulus,Golgi to plasma membrane protein transport,neutrophil degranulation,establishment of neuroblast polarity,membrane organization,basolateral protein localization,endoplasmic reticulum tubular network organization,protein localization to plasma membrane,establishment of protein localization to membrane,establishment of protein localization to endoplasmic reticulum membrane,cell-cell adhesionxGTPase activity,protein binding,GTP binding,GDP binding,myosin V binding,cadherin binding involved in cell-cell adhesionGolgi membrane,endosome,endoplasmic reticulum membrane,Golgi apparatus,trans-Golgi network,cytosol,plasma membrane,cell-cell adherens junction,focal adhesion,cilium,cytoplasmic vesicle membrane,secretory granule membrane,phagocytic vesicle membrane,insulin-responsive compartment,recycling endosome,recycling endosome membrane,extracellular exosome,endoplasmic reticulum tubular network,exocyst\>sp|P61026|RAB10_HUMAN Ras-related protein Rab-10 OS=Homo sapiens OX=9606 GN=RAB10 PE=1 SV=1P22694PRKACB KAPCB_HUMAN4cAMP-dependent protein kinase catalytic subunit betaneural tube closure,stimulatory C-type lectin receptor signaling pathway,renal water homeostasis,protein phosphorylation,signal transduction,adenylate cyclase-modulating G-protein coupled receptor signaling pathway,blood coagulation,activation of protein kinase A activity,lipoprotein metabolic process,negative regulation of meiotic cell cycle,regulation of protein processing,cellular response to glucagon stimulus,response to clozapine,negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningmagnesium ion binding,protein serine/threonine kinase activity,cAMP-dependent protein kinase activity,protein binding,ATP binding,kinase activity,ubiquitin protein ligase bindingnucleoplasm,centrosome,cytosol,plasma membrane,cAMP-dependent protein kinase complex,intercellular bridge,perinuclear region of cytoplasm,extracellular exosome,ciliary basew>sp|P22694|KAPCB_HUMAN cAMP-dependent protein kinase catalytic subunit beta OS=Homo sapiens OX=9606 GN=PRKACB PE=1 SV=2Q5GLZ8HERC4 HERC4_HUMAN*Probable E3 ubiquitin-protein ligase HERC4;spermatogenesis,protein ubiquitination,cell differentiation&ubiquitin-protein transferase activityfibrillar center,cytosoll>sp|Q5GLZ8|HERC4_HUMAN Probable E3 ubiquitin-protein ligase HERC4 OS=Homo sapiens OX=9606 GN=HERC4 PE=1 SV=1Q9UBX1CTSF CATF_HUMAN Cathepsin Fproteolysis,antigen processing and presentation of exogenous peptide antigen via MHC class II,proteolysis involved in cellular protein catabolic process$cysteine-type endopeptidase activityXextracellular space,lysosome,lysosomal lumen,extracellular exosome,extracellular vesicleK>sp|Q9UBX1|CATF_HUMAN Cathepsin F OS=Homo sapiens OX=9606 GN=CTSF PE=1 SV=1P15941MUC1 MUC1_HUMANMucin-1stimulatory C-type lectin receptor signaling pathway,DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest,DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator,negative regulation of transcription by competitive promoter binding,O-glycan processing,negative regulation of cell adhesion mediated by integrin,positive regulation of transcription from RNA polymerase II promoter in response to stress,regulation of transcription from RNA polymerase II promoter in response to stress,positive regulation of histone H4 acetylation,negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorRNA polymerase II core promoter proximal region sequence-specific DNA binding,p53 binding,transcription cofactor activity,protein bindingnuclear chromatin,extracellular space,Golgi lumen,plasma membrane,integral component of plasma membrane,apical plasma membrane,vesicle,extracellular exosomeG>sp|P15941|MUC1_HUMAN Mucin-1 OS=Homo sapiens OX=9606 GN=MUC1 PE=1 SV=3Q9Y2E5MAN2B2 MA2B2_HUMAN%Epididymis-specific alpha-mannosidaseSmannose metabolic process,protein deglycosylation,oligosaccharide catabolic processkalpha-mannosidase activity,zinc ion binding,mannan endo-1,6-alpha-mannosidase activity,carbohydrate binding9extracellular space,lysosomal lumen,extracellular exosomeh>sp|Q9Y2E5|MA2B2_HUMAN Epididymis-specific alpha-mannosidase OS=Homo sapiens OX=9606 GN=MAN2B2 PE=1 SV=4Q8TD55PLEKHO2 PKHO2_HUMAN7Pleckstrin homology domain-containing family O member 2neutrophil degranulation1extracellular region,ficolin-1-rich granule lumen{>sp|Q8TD55|PKHO2_HUMAN Pleckstrin homology domain-containing family O member 2 OS=Homo sapiens OX=9606 GN=PLEKHO2 PE=1 SV=1Q9NR31SAR1A SAR1A_HUMANGTP-binding protein SAR1a:intracellular protein transport,vesicle-mediated transportprotein binding,GTP binding;endoplasmic reticulum,Golgi apparatus,extracellular exosome[>sp|Q9NR31|SAR1A_HUMAN GTP-binding protein SAR1a OS=Homo sapiens OX=9606 GN=SAR1A PE=1 SV=1Q99584S100A13 S10AD_HUMANProtein S100-A13positive regulation of cell proliferation,regulation of cell shape,positive regulation of I-kappaB kinase/NF-kappaB signaling,mast cell degranulation,response to copper ion,cytokine secretion,interleukin-1 alpha secretion,response to electrical stimuluscopper ion binding,calcium ion binding,protein binding,zinc ion binding,lipid binding,fibroblast growth factor binding,protein homodimerization activity,RAGE receptor bindingextracellular space,nucleus,nucleolus,cytoplasm,cytosol,plasma membrane,mast cell granule,perinuclear region of cytoplasm,extracellular exosomeT>sp|Q99584|S10AD_HUMAN Protein S100-A13 OS=Homo sapiens OX=9606 GN=S100A13 PE=1 SV=1P49207RPL34< RL34_HUMAN60S ribosomal protein L34nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,viral transcription,ribosome biogenesis?RNA binding,structural constituent of ribosome,cadherin bindingMmitochondrion,cytosol,cytosolic large ribosomal subunit,extracellular exosomeZ>sp|P49207|RL34_HUMAN 60S ribosomal protein L34 OS=Homo sapiens OX=9606 GN=RPL34 PE=1 SV=3Q8IWE2FAM114A1 NXP20_HUMANProtein NOXP20+nucleus,nucleoplasm,Golgi apparatus,cytosolS>sp|Q8IWE2|NXP20_HUMAN Protein NOXP20 OS=Homo sapiens OX=9606 GN=FAM114A1 PE=1 SV=2P00751CFB CFAB_HUMANComplement factor Bpproteolysis,complement activation,complement activation, alternative pathway,regulation of complement activation5complement binding,serine-type endopeptidase activitybextracellular region,extracellular space,plasma membrane,extracellular exosome,blood microparticleR>sp|P00751|CFAB_HUMAN Complement factor B OS=Homo sapiens OX=9606 GN=CFB PE=1 SV=2Q9Y6Y8SEC23IP S23IP_HUMANSEC23-interacting proteinointracellular protein transport,ER to Golgi vesicle-mediated transport,Golgi organization,COPII vesicle coatingDRNA binding,phospholipase activity,protein binding,metal ion bindingGolgi membrane,cytoplasm,endoplasmic reticulum,endoplasmic reticulum-Golgi intermediate compartment,Golgi apparatus,cytosol,ER to Golgi transport vesicle membrane,ER to Golgi transport vesicle,intracellular membrane-bounded organelle]>sp|Q9Y6Y8|S23IP_HUMAN SEC23-interacting protein OS=Homo sapiens OX=9606 GN=SEC23IP PE=1 SV=1P30411BDKRB2 BKRB2_HUMANB2 bradykinin receptorNsmooth muscle contraction,inflammatory response,cell surface receptor signaling pathway,transmembrane receptor protein tyrosine kinase signaling pathway,G-protein coupled receptor signaling pathway,positive regulation of cytosolic calcium ion concentration,blood circulation,response to salt stress,regulation of vasoconstriction,negative regulation of peptidyl-serine phosphorylation,vasoconstriction,vasodilation,regulation of vascular permeability,arachidonic acid secretion,negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediatorprotease binding,phosphatidylinositol phospholipase C activity,bradykinin receptor activity,protein binding,type 1 angiotensin receptor binding,protein heterodimerization activity>endosome,plasma membrane,integral component of plasma membraneY>sp|P30411|BKRB2_HUMAN B2 bradykinin receptor OS=Homo sapiens OX=9606 GN=BDKRB2 PE=1 SV=2O60610DIAPH1 DIAP1_HUMANProtein diaphanous homolog 1pcytoskeleton organization,sensory perception of sound,regulation of cell shape,actin filament polymerization,positive regulation of cell migration,regulation of microtubule-based process,protein localization to microtubule,neutrophil degranulation,regulation of release of sequestered calcium ion into cytosol,cellular response to histamine,regulation of cell motilityaRNA binding,actin binding,receptor binding,protein binding,Rho GTPase binding,ion channel bindingmicrotubule organizing center,cytosol,plasma membrane,secretory granule membrane,ruffle membrane,mitotic spindle,ficolin-1-rich granule membrane_>sp|O60610|DIAP1_HUMAN Protein diaphanous homolog 1 OS=Homo sapiens OX=9606 GN=DIAPH1 PE=1 SV=2Q96A65EXOC4 EXOC4_HUMANExocyst complex component 4protein targeting to membrane,exocytosis,Golgi to plasma membrane transport,vesicle targeting,vesicle docking involved in exocytosis,chemical synaptic transmission,regulation of macroautophagy,paraxial mesoderm formationPprotein binding,Ral GTPase binding,PDZ domain binding,protein N-terminus bindingyexocyst,cytoplasm,cytosol,plasma membrane,microvillus,membrane,growth cone membrane,myelin sheath abaxonal region,synapse]>sp|Q96A65|EXOC4_HUMAN Exocyst complex component 4 OS=Homo sapiens OX=9606 GN=EXOC4 PE=1 SV=1P63167DYNLL1 DYL1_HUMAN!Dynein light chain 1, cytoplasmicG2/M transition of mitotic cell cycle,transcription, DNA-templated,regulation of transcription, DNA-templated,ER to Golgi vesicle-mediated transport,apoptotic process,viral process,macroautophagy,antigen processing and presentation of exogenous peptide antigen via MHC class II,substantia nigra development,intraciliary retrograde transport,intraciliary transport involved in cilium morphogenesis,negative regulation of phosphorylation,neutrophil degranulation,motile cilium assembly,ciliary basal body docking,positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway,positive regulation of nonmotile primary cilium assembly{motor activity,protein binding,protein C-terminus binding,protein domain specific binding,dynein intermediate chain bindingkinetochore,nucleus,cytoplasm,mitochondrion,centrosome,cytosol,cytoplasmic dynein complex,microtubule,plasma membrane,cilium,membrane,extracellular exosome,tertiary granule membrane,mitotic spindle,ciliary tip,ficolin-1-rich granule membrane,COP9 signalosomec>sp|P63167|DYL1_HUMAN Dynein light chain 1, cytoplasmic OS=Homo sapiens OX=9606 GN=DYNLL1 PE=1 SV=1Q00888PSG4 PSG4_HUMAN(Pregnancy-specific beta-1-glycoprotein 4female pregnancyh>sp|Q00888|PSG4_HUMAN Pregnancy-specific beta-1-glycoprotein 4 OS=Homo sapiens OX=9606 GN=PSG4 PE=2 SV=3O60826CCDC22 CCD22_HUMAN(Coiled-coil domain-containing protein 22Xcellular copper ion homeostasis,Golgi to plasma membrane transport,cytoplasmic sequestering of NF-kappaB,protein transport,positive regulation of I-kappaB kinase/NF-kappaB signaling,negative regulation of I-kappaB kinase/NF-kappaB signaling,positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process-protein binding,cullin family protein bindingcellular_component,endosomek>sp|O60826|CCD22_HUMAN Coiled-coil domain-containing protein 22 OS=Homo sapiens OX=9606 GN=CCDC22 PE=1 SV=1O43169CYB5B CYB5B_HUMANCytochrome b5 type B8xenobiotic metabolic process,oxidation-reduction process.protein binding,heme binding,metal ion bindingDmitochondrial outer membrane,membrane,integral component of membraneV>sp|O43169|CYB5B_HUMAN Cytochrome b5 type B OS=Homo sapiens OX=9606 GN=CYB5B PE=1 SV=3P49257LMAN1 LMAN1_HUMANProtein ERGIC-53:protein folding,ER to Golgi vesicle-mediated transport,endoplasmic reticulum organization,Golgi organization,blood coagulation,positive regulation of organelle organization,protein N-linked glycosylation via asparagine,COPII vesicle coating,protein exit from endoplasmic reticulum,early endosome to Golgi transportJprotein binding,mannose binding,metal ion binding,unfolded protein binding9Golgi membrane,endoplasmic reticulum membrane,endoplasmic reticulum-Golgi intermediate compartment,ER to Golgi transport vesicle membrane,membrane,integral component of membrane,sarcomere,endoplasmic reticulum-Golgi intermediate compartment membrane,host cell perinuclear region of cytoplasm,extracellular exosomeR>sp|P49257|LMAN1_HUMAN Protein ERGIC-53 OS=Homo sapiens OX=9606 GN=LMAN1 PE=1 SV=2O75348ATP6V1G1 VATG1_HUMAN V-type proton ATPase subunit G 1insulin receptor signaling pathway,regulation of macroautophagy,transferrin transport,ion transmembrane transport,phagosome acidification,hydrogen ion transmembrane transport\protein binding,hydrogen-exporting ATPase activity, phosphorylative mechanism,ATPase bindingslysosomal membrane,cytosol,plasma membrane,vacuolar proton-transporting V-type ATPase complex,extracellular exosomee>sp|O75348|VATG1_HUMAN V-type proton ATPase subunit G 1 OS=Homo sapiens OX=9606 GN=ATP6V1G1 PE=1 SV=3Q8NC51SERBP1 PAIRB_HUMAN5Plasminogen activator inhibitor 1 RNA-binding protein<regulation of apoptotic process,regulation of mRNA stability@RNA binding,mRNA 3'-UTR binding,protein binding,cadherin binding^nucleus,cytosol,plasma membrane,membrane,perinuclear region of cytoplasm,extracellular exosomex>sp|Q8NC51|PAIRB_HUMAN Plasminogen activator inhibitor 1 RNA-binding protein OS=Homo sapiens OX=9606 GN=SER< BP1 PE=1 SV=2Q14160SCRIB SCRIB_HUMANProtein scribble homologneural tube closure,positive regulation of receptor recycling,chemical synaptic transmission,asymmetric protein localization,cell proliferation,viral process,synaptic vesicle targeting,single organismal cell-cell adhesion,cell migration,cochlear nucleus development,establishment of apical/basal cell polarity,wound healing,positive regulation of apoptotic process,receptor clustering,astrocyte cell migration,establishment or maintenance of epithelial cell apical/basal polarity,negative regulation of mitotic cell cycle,GMP metabolic process,GDP metabolic process,synaptic vesicle endocytosis,positive chemotaxis,auditory receptor cell stereocilium organization,apoptotic process involved in morphogenesis,mammary gland duct morphogenesis,protein localization to adherens junction,activation of GTPase activity,receptor localization to synapse,neurotransmitter receptor transport, endosome to postsynaptic membrane,neurotransmitter receptor transport postsynaptic membrane to endosome`guanylate kinase activity,protein binding,ionotropic glutamate receptor binding,cadherin bindingdnucleoplasm,plasma membrane,cell-cell junction,cell-cell adherens junction,postsynaptic density,basolateral plasma membrane,lamellipodium,cell junction,Scrib-APC-beta-catenin complex,myelin sheath abaxonal region,cell-cell contact zone,extracellular exosome,ionotropic glutamate receptor complex,cell leading edge,presynaptic membrane,postsynaptic membraneZ>sp|Q14160|SCRIB_HUMAN Protein scribble homolog OS=Homo sapiens OX=9606 GN=SCRIB PE=1 SV=4Q9Y2G5POFUT2 OFUT2_HUMAN)GDP-fucose protein O-fucosyltransferase 2mesoderm formation,fucose metabolic process,regulation of gene expression,regulation of epithelial to mesenchymal transition,protein O-linked fucosylation,regulation of secretion%peptide-O-fucosyltransferase activity.endoplasmic reticulum membrane,Golgi apparatusl>sp|Q9Y2G5|OFUT2_HUMAN GDP-fucose protein O-fucosyltransferase 2 OS=Homo sapiens OX=9606 GN=POFUT2 PE=1 SV=3P31146CORO1A COR1A_HUMAN Coronin-1A\phagolysosome assembly,calcium ion transport,phagocytosis,movement of cell or subcellular component,actin filament organization,regulation of cell shape,actin cytoskeleton organization,positive regulation of cell migration,leukocyte chemotaxis,negative regulation of vesicle fusion,cell-substrate adhesion,uropod organization,regulation of actin cytoskeleton organization,nerve growth factor signaling pathway,positive regulation of T cell proliferation,T cell homeostasis,natural killer cell degranulation,negative regulation of neuron apoptotic process,innate immune response,homeostasis of number of cells within a tissue,positive chemotaxis,negative regulation of actin nucleation,regulation of release of sequestered calcium ion into cytosol,early endosome to recycling endosome transport,cellular response to interleukin-4,immunological synapse formationRNA binding,actin binding,actin monomer binding,protein binding,protein C-terminus binding,cytoskeletal protein binding,myosin heavy chain binding,protein homodimerization activity,phosphatidylinositol 3-kinase binding,actin filament binding immunological synapse,phagocytic cup,cytoplasm,early endosome,cytosol,actin filament,plasma membrane,cell-cell junction,membrane,lamellipodium,axon,phagocytic vesicle membrane,cortical actin cytoskeleton,protein complex,phagocytic vesicle,extracellular exosome,nucleusM>sp|P31146|COR1A_HUMAN Coronin-1A OS=Homo sapiens OX=9606 GN=CORO1A PE=1 SV=4P00390GSR GSHR_HUMAN$Glutathione reductase, mitochondrialresponse to reactive oxygen species,glutathione metabolic process,nucleobase-containing small molecule interconversion,cell redox homeostasis,oxidation-reduction process,cellular oxidant detoxificationsglutathione-disulfide reductase activity,electron carrier activity,flavin adenine dinucleotide binding,NADP bindingSmitochondrial matrix,cytosol,external side of plasma membrane,extracellular exosomec>sp|P00390|GSHR_HUMAN Glutathione reductase, mitochondrial OS=Homo sapiens OX=9606 GN=GSR PE=1 SV=2P08697SERPINF2 A2AP_HUMANAlpha-2-antiplasminregulation of blood vessel size by renin-angiotensin,platelet degranulation,acute-phase response,response to organic substance,negative regulation of plasminogen activation,negative regulation of endopeptidase activity,collagen fibril organization,positive regulation of collagen biosynthetic process,fibrinolysis,positive regulation of cell differentiation,positive regulation of transcription from RNA polymerase II promoter,positive regulation of JNK cascade,blood vessel morphogenesis,positive regulation of smooth muscle cell proliferation,positive regulation of stress fiber assembly,negative regulation of fibrinolysis,positive regulation of ERK1 and ERK2 cascade,positive regulation of transforming growth factor beta production,positive regulation of cell-cell adhesion mediated by cadherinprotease binding,endopeptidase inhibitor activity,serine-type endopeptidase inhibitor activity,protein binding,protein homodimerization activityextracellular region,fibrinogen complex,extracellular space,cell surface,platelet alpha granule lumen,extracellular exosome,blood microparticleW>sp|P08697|A2AP_HUMAN Alpha-2-antiplasmin OS=Homo sapiens OX=9606 GN=SERPINF2 PE=1 SV=3Q9Y5X1SNX9 SNX9_HUMANSorting nexin-9mitotic cytokinesis,intracellular protein transport,endocytosis,receptor-mediated endocytosis,mitotic nuclear division,endosomal transport,positive regulation of protein oligomerization,cleavage furrow formation,positive regulation of GTPase activity,positive regulation of protein kinase activity,positive regulation of membrane protein ectodomain proteolysis,lipid tube assembly,membrane organization,membrane tubulationprotein binding,1-phosphatidylinositol binding,ubiquitin protein ligase binding,phosphatidylinositol binding,protein homodimerization activity,cadherin binding,Arp2/3 complex bindingruffle,cytoplasm,trans-Golgi network,cytosol,plasma membrane,cytoplasmic vesicle membrane,extrinsic component of cytoplasmic side of plasma membrane,cytoplasmic vesicle,extracellular exosome,clathrin-coated vesicleO>sp|Q9Y5X1|SNX9_HUMAN Sorting nexin-9 OS=Homo sapiens OX=9606 GN=SNX9 PE=1 SV=1Q15363TMED2 TMED2_HUMAN/Transmembrane emp24 domain-containing protein 2neural tube closure,maternal placenta development,heart looping,intracellular protein transport,ER to Golgi vesicle-mediated transport,retrograde vesicle-mediated transport, Golgi to ER,Golgi organization,positive regulation of gene expression,somite rostral/caudal axis specification,negative regulation of GTPase activity,multicellular organism growth,cargo loading into vesicle,post-anal tail morphogenesis,COPI coating of Golgi vesicle,COPII vesicle coating,labyrinthine layer blood vessel development,protein targeting to plasma membraneGolgi membrane,endoplasmic reticulum,endoplasmic reticulum membrane,endoplasmic reticulum-Golgi intermediate compartment,Golgi apparatus,ER to Golgi transport vesicle membrane,integral component of membrane,transport vesicle,COPI-coated vesicle,COPI-coated vesicle membrane,Golgi cisterna membrane,endoplasmic reticulum-Golgi intermediate compartment membrane,zymogen granule membrane,intracellular membrane-bounded organelleq>sp|Q15363|TMED2_HUMAN Transmembrane emp24 domain-containing protein 2 OS=Homo sapiens OX=9606 GN=TMED2 PE=1 SV=1O75935DCTN3 DCTN3_HUMANDynactin subunit 3G2/M transition of mitotic cell cycle,cytokinesis,ER to Golgi vesicle-mediated transport,microtubule-based process,mitotic nuclear division,antigen processing and presentation of exogenous peptide antigen via MHC class II,ciliary basal body dockingcondensed chromosome kinetochore,nucleolus,centrosome,spindle,cytosol,dynactin complex,midbody,cleavage furrow,perinuclear region of cytoplasmT>sp|O75935|DCTN3_HUMAN Dynactin subunit 3 OS=Homo sapiens OX=9606 GN=DCTN3 PE=1 SV=1Q96AG4LRRC59 LRC59_HUMAN)Leucine-rich repeat-containing protein 59RNA binding,cadherin bindingnuclear envelope,endoplasmic reticulum,endoplasmic reticulum mem< brane,membrane,integral component of membrane,organelle membrane,mitochondrial nucleoidl>sp|Q96AG4|LRC59_HUMAN Leucine-rich repeat-containing protein 59 OS=Homo sapiens OX=9606 GN=LRRC59 PE=1 SV=1Q8TDX7NEK7 NEK7_HUMAN$Serine/threonine-protein kinase Nek7cytokinesis,protein phosphorylation,regulation of mitotic cell cycle,positive regulation of telomere maintenance via telomerase,spindle assembly,positive regulation of telomerase activity,positive regulation of telomere cappingFprotein serine/threonine kinase activity,ATP binding,metal ion bindingLspindle pole,nucleoplasm,cytoplasm,microtubule organizing center,microtubuled>sp|Q8TDX7|NEK7_HUMAN Serine/threonine-protein kinase Nek7 OS=Homo sapiens OX=9606 GN=NEK7 PE=1 SV=1Q9BRK3MXRA8 MXRA8_HUMAN&Matrix remodeling-associated protein 8*establishment of glial blood-brain barriermolecular_functionAcell surface,integral component of membrane,extracellular exosomeh>sp|Q9BRK3|MXRA8_HUMAN Matrix remodeling-associated protein 8 OS=Homo sapiens OX=9606 GN=MXRA8 PE=1 SV=1P17174GOT1 AATC_HUMAN'Aspartate aminotransferase, cytoplasmicgluconeogenesis,2-oxoglutarate metabolic process,oxaloacetate metabolic process,glycerol biosynthetic process,aspartate metabolic process,aspartate biosynthetic process,aspartate catabolic process,glutamate metabolic process,Notch signaling pathway,cellular amino acid biosynthetic process,glutamate catabolic process to aspartate,glutamate catabolic process to 2-oxoglutarate,cellular response to insulin stimulus,response to glucocorticoid,fatty acid homeostasisL-aspartate:2-oxoglutarate aminotransferase activity,phosphatidylserine decarboxylase activity,pyridoxal phosphate binding,carboxylic acid binding,L-cysteine:2-oxoglutarate aminotransferase activity,L-phenylalanine:2-oxoglutarate aminotransferase activity`nucleus,nucleoplasm,cytoplasm,lysosome,cytosol,axon terminus,extracellular exosome,mitochondriong>sp|P17174|AATC_HUMAN Aspartate aminotransferase, cytoplasmic OS=Homo sapiens OX=9606 GN=GOT1 PE=1 SV=3Q09328MGAT5 MGT5A_HUMANGAlpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Aprotein N-linked glycosylationNalpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activitySGolgi membrane,Golgi apparatus,integral component of membrane,extracellular exosome>sp|Q09328|MGT5A_HUMAN Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A OS=Homo sapiens OX=9606 GN=MGAT5 PE=1 SV=1Q8IZP0ABI1 ABI1_HUMANAbl interactor 1somitogenesis,movement of cell or subcellular component,transmembrane receptor protein tyrosine kinase signaling pathway,actin polymerization or depolymerization,negative regulation of cell proliferation,viral process,peptidyl-tyrosine phosphorylation,megakaryocyte development,Fc-gamma receptor signaling pathway involved in phagocytosis,vascular endothelial growth factor receptor signaling pathway,dendrite morphogenesis,positive regulation of protein tyrosine kinase activity,lamellipodium morphogenesisprotein binding,cytoskeletal protein binding,SH3 domain binding,protein tyrosine kinase activator activity,protein complex binding,cadherin bindingintracellular,nucleus,endoplasmic reticulum,cytosol,cytoskeleton,postsynaptic density,lamellipodium,cell junction,filopodium,growth cone,SCAR complex,postsynaptic membrane,extracellular exosomeP>sp|Q8IZP0|ABI1_HUMAN Abl interactor 1 OS=Homo sapiens OX=9606 GN=ABI1 PE=1 SV=4P36021SLC16A2 MOT8_HUMANMonocarboxylate transporter 8transport,monocarboxylic acid transport,sodium-independent organic anion transport,transmembrane transport,thyroid hormone transporttransporter activity,monocarboxylic acid transmembrane transporter activity,symporter activity,thyroid hormone transmembrane transporter activity5plasma membrane,integral component of plasma membrane`>sp|P36021|MOT8_HUMAN Monocarboxylate transporter 8 OS=Homo sapiens OX=9606 GN=SLC16A2 PE=1 SV=2Q969X1TMBIM1 LFG3_HUMANProtein lifeguard 3Fnegative regulation of catalytic activity,neutrophil degranulation,negative regulation of establishment of protein localization to plasma membrane,negative regulation of extrinsic apoptotic signaling pathway via death domain receptors,negative regulation of Fas signaling pathway,positive regulation of blood vessel remodelingdeath receptor bindinglysosomal membrane,Golgi apparatus,plasma membrane,endosome membrane,integral component of membrane,specific granule membrane,intracellular membrane-bounded organelle,extracellular exosomeU>sp|Q969X1|LFG3_HUMAN Protein lifeguard 3 OS=Homo sapiens OX=9606 GN=TMBIM1 PE=1 SV=2P55285CDH6 CADH6_HUMAN Cadherin-6cell adhesion,homophilic cell adhesion via plasma membrane adhesion molecules,Notch signaling pathway,adherens junction organizationK>sp|P55285|CADH6_HUMAN Cadherin-6 OS=Homo sapiens OX=9606 GN=CDH6 PE=1 SV=1P05198EIF2S1 IF2A_HUMAN4Eukaryotic translation initiation factor 2 subunit 1'translational initiation,aging,negative regulation of translational initiation in response to stress,cellular response to amino acid starvation,cellular response to heat,cellular response to UV,response to endoplasmic reticulum stress,PERK-mediated unfolded protein response,protein autophosphorylation,transmembrane transport,positive regulation of neuron death,negative regulation of guanyl-nucleotide exchange factor activity,response to manganese-induced endoplasmic reticulum stress,positive regulation of type B pancreatic cell apoptotic processSRNA binding,translation initiation factor activity,protein binding,ribosome binding8nucleus,cytosol,ribosome,polysome,eukaryotic translation initiation factor 2 complex,cytoplasmic stress granule,membrane,eukaryotic 48S preinitiation complex,multi-eIF complex,translation initiation ternary complex,extracellular exosome,glial limiting end-foot,eukaryotic translation initiation factor 2B complexv>sp|P05198|IF2A_HUMAN Eukaryotic translation initiation factor 2 subunit 1 OS=Homo sapiens OX=9606 GN=EIF2S1 PE=1 SV=3Q9UBI1COMMD3 COMD3_HUMAN COMM domain-containing protein 3utranscription, DNA-templated,regulation of transcription, DNA-templated,sodium ion transport,neutrophil degranulation9extracellular region,nucleus,ficolin-1-rich granule lumenc>sp|Q9UBI1|COMD3_HUMAN COMM domain-containing protein 3 OS=Homo sapiens OX=9606 GN=COMMD3 PE=1 SV=1Q9Y5P6GMPPB GMPPB_HUMAN*Mannose-1-phosphate guanyltransferase beta GDP-mannose biosynthetic processLmannose-1-phosphate guanylyltransferase activity,protein binding,GTP binding-cytoplasm,mitochondrion,extracellular exosomel>sp|Q9Y5P6|GMPPB_HUMAN Mannose-1-phosphate guanyltransferase beta OS=Homo sapiens OX=9606 GN=GMPPB PE=1 SV=2Q15370ELOB ELOB_HUMAN Elongin-Btranscription from RNA polymerase II promoter,transcription elongation from RNA polymerase II promoter,protein complex assembly,protein ubiquitination,regulation of transcription from RNA polymerase II promoter in response to hypoxia0protein binding,ubiquitin protein ligase bindingnucleoplasm,cytosol,VCB complex,Cul2-RING ubiquitin ligase complex,Cul5-RING ubiquitin ligase complex,extracellular exosome,elongin complexI>sp|Q15370|ELOB_HUMAN Elongin-B OS=Homo sapiens OX=9606 GN=ELOB PE=1 SV=1P54687BCAT1 BCAT1_HUMAN5Branched-chain-amino-acid aminotransferase, cytosolicG1/S transition of mitotic cell cycle,cell proliferation,branched-chain amino acid biosynthetic process,branched-chain amino acid catabolic process,leucine biosynthetic process,valine biosynthetic processbranched-chain-amino-acid transaminase activity,identical protein binding,L-leucine transaminase activity,L-valine transaminase activity,L-isoleucine transaminase activitymitochondrion,cytosolw>sp|P54687|BCAT1_HUMAN Branched-chain-amino-acid aminotransferase, cytosolic OS=Homo sapiens OX=9606 GN=BCAT1 PE=1 SV=3Q9NVD7PARVA PARVA_HUMAN Alpha-parvin@sprouting angiogenesis,outflow tract septum morphogenesis,establishment or maintenance of cell polarity,regulation of cell shape,actin cytoskeleton reorganization,heterotypic cell-cell adhesion,substrate adhesion-< dependent cell spreading,cilium morphogenesis,actin-mediated cell contraction,smooth muscle cell chemotaxis.actin binding,protein binding,cadherin binding:cytosol,cytoskeleton,plasma membrane,focal adhesion,Z discN>sp|Q9NVD7|PARVA_HUMAN Alpha-parvin OS=Homo sapiens OX=9606 GN=PARVA PE=1 SV=1P12821ACE ACE_HUMANAngiotensin-converting enzymekidney development,blood vessel remodeling,angiotensin maturation,angiotensin catabolic process in blood,regulation of renal output by angiotensin,neutrophil mediated immunity,antigen processing and presentation of peptide antigen via MHC class I,regulation of systemic arterial blood pressure by renin-angiotensin,spermatogenesis,regulation of blood pressure,regulation of smooth muscle cell migration,regulation of vasoconstriction,mononuclear cell proliferation,hormone catabolic process,peptide catabolic process,beta-amyloid metabolic process,arachidonic acid secretion,heart contraction,regulation of angiotensin metabolic process,hematopoietic stem cell differentiation,positive regulation of protein tyrosine kinase activity,cell proliferation in bone marrow,Requires Ontology,positive regulation of peptidyl-tyrosine autophosphorylation,regulation of hematopoietic stem cell proliferation,negative regulation of gap junction assembly,positive regulation of peptidyl-cysteine S-nitrosylationaendopeptidase activity,carboxypeptidase activity,drug binding,metallopeptidase activity,exopeptidase activity,tripeptidyl-peptidase activity,peptidyl-dipeptidase activity,zinc ion binding,chloride ion binding,mitogen-activated protein kinase kinase binding,bradykinin receptor binding,mitogen-activated protein kinase binding,metallodipeptidase activityextracellular region,extracellular space,lysosome,endosome,plasma membrane,external side of plasma membrane,integral component of membrane,extracellular exosome[>sp|P12821|ACE_HUMAN Angiotensin-converting enzyme OS=Homo sapiens OX=9606 GN=ACE PE=1 SV=1P51636CAV2 CAV2_HUMAN Caveolin-2negative regulation of endothelial cell proliferation,positive regulation of endothelial cell proliferation,vesicle fusion,mitochondrion organization,endoplasmic reticulum organization,regulation of mitotic nuclear division,insulin receptor signaling pathway,vesicle organization,receptor-mediated endocytosis of virus by host cell,negative regulation of transforming growth factor beta receptor signaling pathway,positive regulation of MAPK cascade,positive regulation of GTPase activity,positive regulation by host of viral release from host cell,positive regulation by host of viral process,vesicle docking,skeletal muscle fiber development,protein oligomerization,positive regulation of dopamine receptor signaling pathway,caveola assemblyprotein binding,protein kinase binding,protein binding, bridging,protein complex scaffold,protein homodimerization activity,protein heterodimerization activity,scaffold protein binding3Golgi membrane,acrosomal membrane,intracellular,nucleus,Golgi apparatus,plasma membrane,integral component of plasma membrane,caveola,transport vesicle,extrinsic component of cytoplasmic side of plasma membrane,cytoplasmic vesicle,protein complex,membrane raft,perinuclear region of cytoplasm,focal adhesionJ>sp|P51636|CAV2_HUMAN Caveolin-2 OS=Homo sapiens OX=9606 GN=CAV2 PE=1 SV=2P12270TPR TPR_HUMANNucleoprotein TPRnegative regulation of transcription from RNA polymerase II promoter,MAPK import into nucleus,RNA import into nucleus,RNA export from nucleus,mRNA export from nucleus,tRNA export from nucleus,nuclear pore organization,mitotic nuclear division,mitotic nuclear envelope disassembly,mitotic spindle assembly checkpoint,biological_process,regulation of glucose transport,regulation of mitotic sister chromatid separation,viral process,protein sumoylation,viral transcription,gene silencing by RNA,positive regulation of heterochromatin assembly,mRNA export from nucleus in response to heat stress,cellular response to heat,cellular response to interferon-alpha,positive regulation of protein import into nucleus,negative regulation of translational initiation,positive regulation of protein export from nucleus,negative regulation of RNA export from nucleus,cell division,response to epidermal growth factor,intracellular transport of virus,positive regulation of mitotic cell cycle spindle assembly checkpoint,positive regulation of intracellular protein transport,regulation of cellular response to heat,regulation of mitotic spindle assembly,protein import into nucleus,protein export from nucleus,regulation of mRNA export from nucleus,regulation of protein stability,regulation of protein import into nucleus,nuclear matrix organization,regulation of protein export from nucleus,nuclear pore complex assembly%molecular_function,chromatin binding,RNA binding,mRNA binding,nucleocytoplasmic transporter activity,protein binding,tubulin binding,heat shock protein binding,protein homodimerization activity,mitogen-activated protein kinase binding,dynein complex binding,transporter activity,protein anchorkinetochore,cellular_component,nucleus,nuclear envelope,nuclear pore,nucleoplasm,cytoplasm,cytoplasmic dynein complex,extrinsic component of membrane,nuclear membrane,nuclear periphery,nuclear inclusion body,nuclear pore nuclear basket,mitotic spindleO>sp|P12270|TPR_HUMAN Nucleoprotein TPR OS=Homo sapiens OX=9606 GN=TPR PE=1 SV=3Q92791P3H4 SC65_HUMAN"Endoplasmic reticulum protein SC65synaptonemal complex assembly;condensed nuclear chromosome,synaptonemal complex,nucleolusb>sp|Q92791|SC65_HUMAN Endoplasmic reticulum protein SC65 OS=Homo sapiens OX=9606 GN=P3H4 PE=1 SV=1Q9UL46PSME2 PSME2_HUMAN&Proteasome activator complex subunit 2!MAPK cascade,protein polyubiquitination,stimulatory C-type lectin receptor signaling pathway,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent,regulation of cellular amino acid metabolic process,positive regulation of endopeptidase activity,negative regulation of G2/M transition of mitotic cell cycle,protein deubiquitination,anaphase-promoting complex-dependent catabolic process,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process,tumor necrosis factor-mediated signaling pathway,NIK/NF-kappaB signaling,Fc-epsilon receptor signaling pathway,proteasome-mediated ubiquitin-dependent protein catabolic process,regulation of mRNA stability,T cell receptor signaling pathway,negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition,transmembrane transport,Wnt signaling pathway, planar cell polarity pathway,regulation of proteasomal protein catabolic process,regulation of transcription from RNA polymerase II promoter in response to hypoxia,negative regulation of canonical Wnt signaling pathway,positive regulation of canonical Wnt signaling pathway,regulation of G1/S transition of mitotic cell cycleJprotein binding,identical protein binding,endopeptidase activator activitylproteasome complex,nucleoplasm,cytoplasm,cytosol,proteasome activator complex,membrane,extracellular exosomeh>sp|Q9UL46|PSME2_HUMAN Proteasome activator complex subunit 2 OS=Homo sapiens OX=9606 GN=PSME2 PE=1 SV=4Q13131PRKAA1 AAPK1_HUMAN95'-AMP-activated protein kinase catalytic subunit alpha-1activation of MAPK activity,response to hypoxia,glucose metabolic process,transcription, DNA-templated,regulation of transcription, DNA-templated,protein phosphorylation,fatty acid biosynthetic process,cholesterol biosynthetic process,cell cycle arrest,signal transduction,positive regulation of cell proliferation,lipid biosynthetic process,response to UV,cold acclimation,response to gamma radiation,positive regulation of autophagy,positive regulation of gene expression,response to activity,Wnt signaling pathway,macroautophagy,fatty acid oxidation,response to caffeine,cellular response to nutrient levels,negative regulation of TOR signaling,regulation of peptidyl-serine phosphorylation,histone-serine phosphorylation,intracellular signal transduction,< cellular response to glucose starvation,glucose homeostasis,regulation of circadian rhythm,negative regulation of apoptotic process,positive regulation of cholesterol biosynthetic process,positive regulation of glycolytic process,negative regulation of glucosylceramide biosynthetic process,rhythmic process,positive regulation of skeletal muscle tissue development,negative regulation of lipid catabolic process,protein heterooligomerization,fatty acid homeostasis,regulation of vesicle-mediated transport,CAMKK-AMPK signaling cascade,cellular response to hydrogen peroxide,cellular response to ethanol,cellular response to prostaglandin E stimulus,cellular response to organonitrogen compound,cellular response to hypoxia,response to camptothecin,regulation of signal transduction by p53 class mediator,regulation of energy homeostasis,negative regulation of glucose import in response to insulin stimuluspchromatin binding,protein kinase activity,AMP-activated protein kinase activity,cAMP-dependent protein kinase activity,protein binding,ATP binding,protein C-terminus binding,kinase binding,histone serine kinase activity,metal ion binding,[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity,tau-protein kinase activity,[acetyl-CoA carboxylase] kinase activityintracellular,nucleus,nucleoplasm,cytoplasm,cytosol,apical plasma membrane,nuclear speck,nucleotide-activated protein kinase complex|>sp|Q13131|AAPK1_HUMAN 5'-AMP-activated protein kinase catalytic subunit alpha-1 OS=Homo sapiens OX=9606 GN=PRKAA1 PE=1 SV=4 Q96J02;Q9H0M0 ITCH;WWP1ITCH_HUMAN;WWP1_HUMANUE3 ubiquitin-protein ligase Itchy homolog;NEDD4-like E3 ubiquitin-protein ligase WWP1regulation of cell growth,positive regulation of T cell anergy,ubiquitin-dependent protein catabolic process,apoptotic process,inflammatory response,Notch signaling pathway,protein ubiquitination,negative regulation of NF-kappaB transcription factor activity,negative regulation of type I interferon production,protein K29-linked ubiquitination,protein ubiquitination involved in ubiquitin-dependent protein catabolic process,negative regulation of apoptotic process,innate immune response,positive regulation of protein catabolic process,negative regulation of JNK cascade,negative regulation of alpha-beta T cell proliferation,viral entry into host cell,negative regulation of defense response to virus,defense response to virus,nucleotide-binding oligomerization domain containing signaling pathway,protein K63-linked ubiquitination,protein K48-linked ubiquitination,regulation of protein deubiquitination;signal transduction,central nervous system development,protein ubiquitination,ion transmembrane transport,proteasome-mediated ubiquitin-dependent protein catabolic process,negative regulation of transcription, DNA-templated,viral entry into host cell/ubiquitin-protein transferase activity,protein binding,ligase activity,ubiquitin-like protein transferase activity,ribonucleoprotein complex binding,CXCR chemokine receptor binding,ubiquitin protein ligase activity;ubiquitin-protein transferase activity,protein binding,ubiquitin protein ligase activitynucleoplasm,cytosol,plasma membrane,cell cortex,membrane,cytoplasmic vesicle,extracellular exosome;ubiquitin ligase complex,nucleus,cytosol,plasma membrane,extracellular exosome2;1>sp|Q96J02|ITCH_HUMAN E3 ubiquitin-protein ligase Itchy homolog OS=Homo sapiens OX=9606 GN=ITCH PE=1 SV=2;>sp|Q9H0M0|WWP1_HUMAN NEDD4-like E3 ubiquitin-protein ligase WWP1 OS=Homo sapiens OX=9606 GN=WWP1 PE=1 SV=1Q05707COL14A1 COEA1_HUMANCollagen alpha-1(XIV) chaincsingle organismal cell-cell adhesion,extracellular matrix organization,collagen fibril organizationbRNA binding,extracellular matrix structural constituent,collagen binding,protein binding, bridgingextracellular region,proteinaceous extracellular matrix,collagen trimer,collagen type XIV trimer,extracellular space,endoplasmic reticulum lumen,extracellular exosome,extracellular matrix_>sp|Q05707|COEA1_HUMAN Collagen alpha-1(XIV) chain OS=Homo sapiens OX=9606 GN=COL14A1 PE=1 SV=3Q9H269VPS16 VPS16_HUMAN6Vacuolar protein sorting-associated protein 16 homologintracellular protein transport,endosome to lysosome transport,regulation of vacuole fusion, non-autophagic,regulation of SNARE complex assembly,autophagosome maturation4actin binding,protein binding,actin filament bindinglysosome,lysosomal membrane,early endosome,late endosome,autophagosome,clathrin-coated vesicle,axon,HOPS complex,late endosome membrane,neuronal cell body,recycling endosomex>sp|Q9H269|VPS16_HUMAN Vacuolar protein sorting-associated protein 16 homolog OS=Homo sapiens OX=9606 GN=VPS16 PE=1 SV=2 P14678;P63162 SNRPB;SNRPNRSMB_HUMAN;RSMN_HUMANqSmall nuclear ribonucleoprotein-associated proteins B and B';Small nuclear ribonucleoprotein-associated protein Nspliceosomal snRNP assembly,mRNA splicing, via spliceosome,termination of RNA polymerase II transcription,protein methylation,histone mRNA metabolic process,RNA splicing,nuclear import;mRNA splicing, via spliceosome,RNA splicing,response to hormone|RNA binding,protein binding,U2 snRNA binding,telomerase RNA binding,histone pre-mRNA DCP binding;RNA binding,protein binding5nucleoplasm,spliceosomal complex,U5 snRNP,U7 snRNP,U1 snRNP,U2 snRNP,U4 snRNP,U12-type spliceosomal complex,cytosol,small nuclear ribonucleoprotein complex,methylosome,SMN-Sm protein complex,U4/U6 x U5 tri-snRNP complex,extracellular exosome,U2-type prespliceosome,catalytic step 2 spliceosome,histone pre-mRNA 3'end processing complex,telomerase holoenzyme complex;nucleoplasm,spliceosomal complex,U5 snRNP,U1 snRNP,U2 snRNP,U4 snRNP,cytoplasm,small nuclear ribonucleoprotein complex,U4/U6 x U5 tri-snRNP complex,U2-type prespliceosome,catalytic step 2 spliceosome>sp|P14678|RSMB_HUMAN Small nuclear ribonucleoprotein-associated proteins B and B' OS=Homo sapiens OX=9606 GN=SNRPB PE=1 SV=2;>sp|P63162|RSMN_HUMAN Small nuclear ribonucleoprotein-associated protein N OS=Homo sapiens OX=9606 GN=SNRPN PE=1 SV=1Q14624ITIH4 ITIH4_HUMAN,Inter-alpha-trypsin inhibitor heavy chain H4platelet degranulation,acute-phase response,negative regulation of endopeptidase activity,hyaluronan metabolic process,response to cytokine]endopeptidase inhibitor activity,serine-type endopeptidase inhibitor activity,protein bindingkextracellular region,plasma membrane,platelet dense granule lumen,extracellular exosome,blood microparticlen>sp|Q14624|ITIH4_HUMAN Inter-alpha-trypsin inhibitor heavy chain H4 OS=Homo sapiens OX=9606 GN=ITIH4 PE=1 SV=4O75695RP2 XRP2_HUMAN Protein XRP2cell morphogenesis,protein folding,post-Golgi vesicle-mediated transport,cytoskeleton organization,visual perception,protein transport,positive regulation of GTPase activity,post-chaperonin tubulin folding pathway\actin binding,GTPase activator activity,protein binding,GTP binding,unfolded protein bindingnucleoplasm,cytoplasm,Golgi apparatus,centriole,plasma membrane,cilium,nuclear body,cytoplasmic vesicle,ciliary basal body,extracellular exosome,periciliary membrane compartmentK>sp|O75695|XRP2_HUMAN Protein XRP2 OS=Homo sapiens OX=9606 GN=RP2 PE=1 SV=4Q9NVM1EVA1B EVA1B_HUMANProtein eva-1 homolog Bintegral component of membraneY>sp|Q9NVM1|EVA1B_HUMAN Protein eva-1 homolog B OS=Homo sapiens OX=9606 GN=EVA1B PE=1 SV=1Q15046KARS1 SYK_HUMANLysine--tRNA ligasetRNA aminoacylation for protein translation,lysyl-tRNA aminoacylation,tRNA processing,diadenosine tetraphosphate biosynthetic process,viral processitRNA binding,lysine-tRNA ligase activity,protein binding,ATP binding,amino acid binding,metal ion bindingextracellular region,nucleus,cytoplasm,mitochondrion,mitochondrial matrix,cytosol,plasma membrane,aminoacyl-tRNA synthetase multienzyme complexS>sp|Q15046|SYK_HUMAN Lysine--tRNA ligase OS=Homo sapiens OX=9606 GN=KARS1 PE=1 SV=3Q9C0B5ZDHHC5 ZDHC5_HUMANPalmitoyltransferase ZDHHC5protein palmitoylationNpalmitoyltransferase activity,protein-cysteine S-palmitoyltransferase activityJcytoplasm,plasma membrane,membrane,integral component of membrane,dendrite^>sp|Q9C0B5|ZDHC5_HUMA< N Palmitoyltransferase ZDHHC5 OS=Homo sapiens OX=9606 GN=ZDHHC5 PE=1 SV=2Q96CX2KCTD12 KCD12_HUMAN(BTB/POZ domain-containing protein KCTD12protein homooligomerization%RNA binding,identical protein bindingNcell junction,presynaptic membrane,postsynaptic membrane,extracellular exosomek>sp|Q96CX2|KCD12_HUMAN BTB/POZ domain-containing protein KCTD12 OS=Homo sapiens OX=9606 GN=KCTD12 PE=1 SV=1P61201COPS2 CSN2_HUMAN"COP9 signalosome complex subunit 2negative regulation of transcription from RNA polymerase II promoter,protein deneddylation,nucleotide-excision repair, DNA damage recognition,transcription-coupled nucleotide-excision repair,transcription from RNA polymerase II promoter,signal transduction,cell proliferation,neurogenesis,neuron differentiation,skeletal muscle cell differentiation,negative regulation of transcription, DNA-templated,negative regulation of nucleic acid-templated transcriptionMtranscription corepressor activity,signal transducer activity,protein binding.nucleoplasm,cytoplasm,cytosol,COP9 signalosomec>sp|P61201|CSN2_HUMAN COP9 signalosome complex subunit 2 OS=Homo sapiens OX=9606 GN=COPS2 PE=1 SV=1Q9BTW9TBCD TBCD_HUMANTubulin-specific chaperone Dprotein folding,tubulin complex assembly,post-chaperonin tubulin folding pathway,negative regulation of cell-substrate adhesion,negative regulation of microtubule polymerization,adherens junction assembly,positive regulation of GTPase activity,bicellular tight junction assemblyPGTPase activator activity,protein binding,beta-tubulin binding,chaperone bindingYcytoplasm,microtubule,adherens junction,bicellular tight junction,lateral plasma membrane\>sp|Q9BTW9|TBCD_HUMAN Tubulin-specific chaperone D OS=Homo sapiens OX=9606 GN=TBCD PE=1 SV=2P54727RAD23B RD23B_HUMAN*UV excision repair protein RAD23 homolog Bnucleotide-excision repair, DNA damage recognition,nucleotide-excision repair, DNA duplex unwinding,nucleotide-excision repair,nucleotide-excision repair, preincision complex assembly,protein folding,spermatogenesis,protein deubiquitination,regulation of proteasomal ubiquitin-dependent protein catabolic process,proteasome-mediated ubiquitin-dependent protein catabolic process,embryonic organ development,global genome nucleotide-excision repairUdamaged DNA binding,single-stranded DNA binding,protein binding,polyubiquitin binding:proteasome complex,nucleus,nucleoplasm,cytosol,XPC complexm>sp|P54727|RD23B_HUMAN UV excision repair protein RAD23 homolog B OS=Homo sapiens OX=9606 GN=RAD23B PE=1 SV=1Q96S86HAPLN3 HPLN3_HUMAN*Hyaluronan and proteoglycan link protein 3Lskeletal system development,cell adhesion,central nervous system developmentCextracellular matrix structural constituent,hyaluronic acid binding6proteinaceous extracellular matrix,extracellular spacem>sp|Q96S86|HPLN3_HUMAN Hyaluronan and proteoglycan link protein 3 OS=Homo sapiens OX=9606 GN=HAPLN3 PE=2 SV=1Q99798ACO2 ACON_HUMAN"Aconitate hydratase, mitochondrialliver development,generation of precursor metabolites and energy,tricarboxylic acid cycle,citrate metabolic process,isocitrate metabolic process,response to isolation stressoaconitate hydratase activity,iron ion binding,3 iron, 4 sulfur cluster binding,4 iron, 4 sulfur cluster binding0mitochondrion,mitochondrial matrix,myelin sheathb>sp|Q99798|ACON_HUMAN Aconitate hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=ACO2 PE=1 SV=2Q10469MGAT2 MGAT2_HUMANFAlpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferaseprotein N-linked glycosylation,oligosaccharide metabolic process,oligosaccharide biosynthetic process,protein N-linked glycosylation via asparaginecalpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity,carbohydrate bindingRGolgi membrane,Golgi apparatus,Golgi stack,membrane,integral component of membrane>sp|Q10469|MGAT2_HUMAN Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase OS=Homo sapiens OX=9606 GN=MGAT2 PE=1 SV=1P62318SNRPD3 SMD3_HUMAN%Small nuclear ribonucleoprotein Sm D3spliceosomal complex assembly,spliceosomal snRNP assembly,mRNA splicing, via spliceosome,termination of RNA polymerase II transcription,protein methylation,histone mRNA metabolic process,RNA splicing,nuclear importRNA binding,protein binding,enzyme binding,U2 snRNA binding,telomerase RNA binding,histone pre-mRNA DCP binding,U7 snRNA binding,U1 snRNP bindingcommitment complex,nucleoplasm,spliceosomal complex,U5 snRNP,U7 snRNP,U1 snRNP,U2 snRNP,U4 snRNP,U12-type spliceosomal complex,cytosol,nuclear body,small nuclear ribonucleoprotein complex,methylosome,pICln-Sm protein complex,SMN-Sm protein complex,extracellular exosome,prespliceosome,precatalytic spliceosome,catalytic step 2 spliceosome,spliceosomal tri-snRNP complex,telomerase holoenzyme complexg>sp|P62318|SMD3_HUMAN Small nuclear ribonucleoprotein Sm D3 OS=Homo sapiens OX=9606 GN=SNRPD3 PE=1 SV=1Q9NSD9FARSB SYFB_HUMAN'Phenylalanine--tRNA ligase beta subunitvtranslation,tRNA aminoacylation for protein translation,phenylalanyl-tRNA aminoacylation,protein heterotetramerization`magnesium ion binding,RNA binding,phenylalanine-tRNA ligase activity,protein binding,ATP binding<cytoplasm,cytosol,phenylalanine-tRNA ligase complex,membraneh>sp|Q9NSD9|SYFB_HUMAN Phenylalanine--tRNA ligase beta subunit OS=Homo sapiens OX=9606 GN=FARSB PE=1 SV=3Q969G5CAVIN3 CAVN3_HUMANCaveolae-associated protein 3cortical actin cytoskeleton organization,circadian regulation of gene expression,negative regulation of protein kinase B signaling,positive regulation of ERK1 and ERK2 cascade,negative regulation of fermentation(protein kinase C binding,protein binding!cytoplasm,caveola,protein complex`>sp|Q969G5|CAVN3_HUMAN Caveolae-associated protein 3 OS=Homo sapiens OX=9606 GN=CAVIN3 PE=1 SV=3Q86TI2DPP9 DPP9_HUMANDipeptidyl peptidase 9 proteolysisPaminopeptidase activity,serine-type peptidase activity,identical protein bindingnucleus,cytosolV>sp|Q86TI2|DPP9_HUMAN Dipeptidyl peptidase 9 OS=Homo sapiens OX=9606 GN=DPP9 PE=1 SV=3P25445FAS TNR6_HUMAN3Tumor necrosis factor receptor superfamily member 6immunoglobulin production,renal system process,protein complex assembly,apoptotic process,activation of cysteine-type endopeptidase activity involved in apoptotic process,activation-induced cell death of T cells,inflammatory cell apoptotic process,inflammatory response,immune response,signal transduction,multicellular organism development,circadian rhythm,extrinsic apoptotic signaling pathway via death domain receptors,response to toxic substance,gene expression,B cell mediated immunity,positive regulation of protein homooligomerization,response to lipopolysaccharide,tumor necrosis factor-mediated signaling pathway,regulation of cell proliferation,regulation of apoptotic process,positive regulation of apoptotic process,negative regulation of apoptotic process,negative thymic T cell selection,regulation of lymphocyte differentiation,regulation of myeloid cell differentiation,spleen development,negative regulation of B cell activation,protein homooligomerization,response to glucocorticoid,positive regulation of lymphocyte apoptotic process,cellular response to mechanical stimulus,cellular response to lithium ion,cellular response to hyperoxia,motor neuron apoptotic process,apoptotic signaling pathway,extrinsic apoptotic signaling pathway,extrinsic apoptotic signaling pathway in absence of ligand,hepatocyte apoptotic process,activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway,necroptotic signaling pathway,regulation of extrinsic apoptotic signaling pathway via death domain receptors,negative regulation of extrinsic apoptotic signaling pathway via death domain receptors,positive regulation of extrinsic apoptotic signaling pathway in absence of ligandsignal transducer activity,receptor activity,tumor necrosis factor-activated receptor activity,protein binding,calmodulin binding,kinase binding,identical protein binding,tumor necrosis factor bindingmitochondrion,cytosol,plasma membrane,integral < component of plasma membrane,external side of plasma membrane,cell surface,nuclear body,death-inducing signaling complex,CD95 death-inducing signaling complex,membrane raft,extracellular exosomer>sp|P25445|TNR6_HUMAN Tumor necrosis factor receptor superfamily member 6 OS=Homo sapiens OX=9606 GN=FAS PE=1 SV=1Q8NBZ7UXS1 UXS1_HUMAN#UDP-glucuronic acid decarboxylase 19UDP-D-xylose biosynthetic process,protein tetramerizationUprotein homodimerization activity,UDP-glucuronate decarboxylase activity,NAD+ bindingdcytoplasm,mitochondrion,integral component of membrane,Golgi cisterna membrane,extracellular exosomec>sp|Q8NBZ7|UXS1_HUMAN UDP-glucuronic acid decarboxylase 1 OS=Homo sapiens OX=9606 GN=UXS1 PE=1 SV=1P05062ALDOB ALDOB_HUMAN Fructose-bisphosphate aldolase BFfructose metabolic process,gluconeogenesis,glycolytic process,NADH oxidation,fructose 1,6-bisphosphate metabolic process,positive regulation of ATPase activity,canonical glycolysis,fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate,vacuolar proton-transporting V-type ATPase complex assemblyfructose-bisphosphate aldolase activity,protein binding,cytoskeletal protein binding,identical protein binding,ATPase binding,fructose-1-phosphate aldolase activity,fructose bindingPmicrotubule organizing center,cytosol,centriolar satellite,extracellular exosomeb>sp|P05062|ALDOB_HUMAN Fructose-bisphosphate aldolase B OS=Homo sapiens OX=9606 GN=ALDOB PE=1 SV=2P37173TGFBR2 TGFR2_HUMANTGF-beta receptor type-2 blood vessel development,patterning of blood vessels,vasculogenesis,response to hypoxia,in utero embryonic development,heart looping,positive regulation of mesenchymal cell proliferation,lens development in camera-type eye,positive regulation of tolerance induction to self antigen,positive regulation of B cell tolerance induction,positive regulation of T cell tolerance induction,outflow tract septum morphogenesis,membranous septum morphogenesis,outflow tract morphogenesis,atrioventricular valve morphogenesis,tricuspid valve morphogenesis,cardiac left ventricle morphogenesis,endocardial cushion fusion,growth plate cartilage chondrocyte growth,protein phosphorylation,receptor-mediated endocytosis,apoptotic process,transforming growth factor beta receptor signaling pathway,common-partner SMAD protein phosphorylation,Notch signaling pathway,smoothened signaling pathway,gastrulation,brain development,heart development,embryo implantation,aging,response to nutrient,positive regulation of cell proliferation,response to mechanical stimulus,response to glucose,regulation of gene expression,positive regulation of epithelial cell migration,positive regulation of epithelial to mesenchymal transition,peptidyl-serine phosphorylation,peptidyl-threonine phosphorylation,signal transduction by protein phosphorylation,negative regulation of transforming growth factor beta receptor signaling pathway,animal organ regeneration,activation of protein kinase activity,embryonic hemopoiesis,wound healing,regulation of cell proliferation,response to drug,myeloid dendritic cell differentiation,positive regulation of skeletal muscle tissue regeneration,response to estrogen,positive regulation of angiogenesis,response to steroid hormone,digestive tract development,positive regulation of smooth muscle cell proliferation,embryonic cranial skeleton morphogenesis,positive regulation of NK T cell differentiation,palate development,negative regulation of cardiac muscle cell proliferation,pathway-restricted SMAD protein phosphorylation,ventricular septum morphogenesis,bronchus morphogenesis,trachea formation,mammary gland morphogenesis,lung lobe morphogenesis,response to cholesterol,positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation,lens fiber cell apoptotic process,positive regulation of reactive oxygen species metabolic process,cell proliferation involved in endocardial cushion morphogenesistransmembrane receptor protein serine/threonine kinase activity,receptor signaling protein serine/threonine kinase activity,transforming growth factor beta-activated receptor activity,transforming growth factor beta receptor activity, type II,protein binding,ATP binding,glycosaminoglycan binding,mitogen-activated protein kinase kinase kinase binding,type I transforming growth factor beta receptor binding,SMAD binding,metal ion binding,transforming growth factor beta bindingcytosol,plasma membrane,caveola,external side of plasma membrane,integral component of membrane,receptor complex,membrane raft,transforming growth factor beta receptor homodimeric complex[>sp|P37173|TGFR2_HUMAN TGF-beta receptor type-2 OS=Homo sapiens OX=9606 GN=TGFBR2 PE=1 SV=2O14817TSPAN4 TSN4_HUMAN Tetraspanin-4@protein complex assembly,cell surface receptor signaling pathway0antigen binding,integrin binding,protein bindingLplasma membrane,integral component of plasma membrane,focal adhesion,vesicleO>sp|O14817|TSN4_HUMAN Tetraspanin-4 OS=Homo sapiens OX=9606 GN=TSPAN4 PE=1 SV=1Q96N67DOCK7 DOCK7_HUMAN"Dedicator of cytokinesis protein 7vmicrotubule cytoskeleton organization,small GTPase mediated signal transduction,axonogenesis,interkinetic nuclear migration,neuron projection development,positive regulation of peptidyl-serine phosphorylation,establishment of neuroblast polarity,regulation of neurogenesis,activation of GTPase activity,positive regulation of vascular associated smooth muscle cell migration=guanyl-nucleotide exchange factor activity,Rac GTPase bindingUfocal adhesion,axon,growth cone,neuron projection,basal part of cell,COP9 signalosomed>sp|Q96N67|DOCK7_HUMAN Dedicator of cytokinesis protein 7 OS=Homo sapiens OX=9606 GN=DOCK7 PE=1 SV=4P24534EEF1B2 EF1B_HUMANElongation factor 1-beta,translational elongation,response to ethanol6translation elongation factor activity,protein bindingbcytoplasm,cytosol,eukaryotic translation elongation factor 1 complex,nucleus,endoplasmic reticulumZ>sp|P24534|EF1B_HUMAN Elongation factor 1-beta OS=Homo sapiens OX=9606 GN=EEF1B2 PE=1 SV=3Q04917YWHAH 1433F_HUMAN14-3-3 protein etaBregulation of sodium ion transport,glucocorticoid catabolic process,intracellular protein transport,substantia nigra development,glucocorticoid receptor signaling pathway,regulation of neuron differentiation,positive regulation of transcription, DNA-templated,regulation of synaptic plasticity,negative regulation of dendrite morphogenesis,membrane organization,membrane depolarization during action potential,positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway,regulation of sodium ion transmembrane transporter activityactin binding,insulin-like growth factor receptor binding,protein binding,sodium channel regulator activity,enzyme binding,protein domain specific binding,glucocorticoid receptor binding,ion channel binding,protein heterodimerization activitytcytoplasm,mitochondrion,cytosol,plasma membrane,intercalated disc,cytoplasmic vesicle membrane,extracellular exosomeT>sp|Q04917|1433F_HUMAN 14-3-3 protein eta OS=Homo sapiens OX=9606 GN=YWHAH PE=1 SV=4P0DN76;Q01081;Q8WU68U2AF1L5;U2AF1;U2AF1L4#U2AF5_HUMAN;U2AF1_HUMAN;U2AF4_HUMANxSplicing factor U2AF 35 kDa subunit-like protein;Splicing factor U2AF 35 kDa subunit;Splicing factor U2AF 26 kDa subunitmRNA splicing, via spliceosome;mRNA splicing, via spliceosome,termination of RNA polymerase II transcription,mRNA processing,RNA export from nucleus,mRNA export from nucleus,RNA splicing,mRNA 3'-end processing,regulation of mitophagy,positive regulation of protein targeting to mitochondrion;mRNA splicing, via spliceosome,termination of RNA polymerase II transcription,RNA export from nucleus,mRNA export from nucleus,mRNA 3'-end processingnucleotide binding,RNA binding,metal ion binding;nucleotide binding,RNA binding,protein binding,pre-mRNA 3'-splice site binding,metal ion binding,RS domain binding;nucleotide binding,pre-mRNA 3'-splice site binding,metal ion bindingnuclear speck,U2AF;nucleoplasm,spliceosomal complex,Cajal body,nuclear speck,catalytic step 2 spl< iceosome,U2AF;nucleoplasm,spliceosomal complex,cytoplasm,nuclear speck,U2AF1;3;2B>sp|P0DN76|U2AF5_HUMAN Splicing factor U2AF 35 kDa subunit-like protein OS=Homo sapiens OX=9606 GN=U2AF1L5 PE=1 SV=1;>sp|Q01081|U2AF1_HUMAN Splicing factor U2AF 35 kDa subunit OS=Homo sapiens OX=9606 GN=U2AF1 PE=1 SV=3;>sp|Q8WU68|U2AF4_HUMAN Splicing factor U2AF 26 kDa subunit OS=Homo sapiens OX=9606 GN=U2AF1L4 PE=1 SV=2Q14956GPNMB GPNMB_HUMANTransmembrane glycoprotein NMBosteoblast differentiation,negative regulation of cytokine production,positive regulation of protein phosphorylation,cell adhesion,signal transduction,cell-cell signaling,negative regulation of cell proliferation,bone mineralization,positive regulation of cell migration,positive regulation of protein autophosphorylation,negative regulation of tumor necrosis factor production,regulation of tissue remodeling,negative regulation of T cell proliferation,regulation of angiogenesis,negative regulation of T cell activation,positive chemotaxis,positive regulation of ERK1 and ERK2 cascade,negative regulation of neuron death,negative regulation of G1/S transition of mitotic cell cycletintegrin binding,protein binding,heparin binding,chemoattractant activity,syndecan binding,receptor agonist activity_plasma membrane,integral component of plasma membrane,integral component of membrane,melanosome`>sp|Q14956|GPNMB_HUMAN Transmembrane glycoprotein NMB OS=Homo sapiens OX=9606 GN=GPNMB PE=1 SV=2P10643C7 CO7_HUMANComplement component C7cellular sodium ion homeostasis,complement activation,complement activation, alternative pathway,complement activation, classical pathway,cytolysis,regulation of complement activationBextracellular region,membrane attack complex,extracellular exosomeT>sp|P10643|CO7_HUMAN Complement component C7 OS=Homo sapiens OX=9606 GN=C7 PE=1 SV=2Q8TDZ2MICAL1 MICA1_HUMAN[F-actin]-monooxygenase MICAL1negative regulation of protein phosphorylation,cytoskeleton organization,signal transduction,sulfur oxidation,actin filament depolymerization,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process,oxidation-reduction processactin binding,protein binding,zinc ion binding,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen,SH3 domain binding,Rab GTPase binding,FAD bindingcytoplasm,intermediate filamenta>sp|Q8TDZ2|MICA1_HUMAN [F-actin]-monooxygenase MICAL1 OS=Homo sapiens OX=9606 GN=MICAL1 PE=1 SV=2Q9UQ03CORO2B COR2B_HUMAN Coronin-2Bactin cytoskeleton organization%cytoplasm,actin cytoskeleton,membraneM>sp|Q9UQ03|COR2B_HUMAN Coronin-2B OS=Homo sapiens OX=9606 GN=CORO2B PE=1 SV=4Q15386UBE3C UBE3C_HUMANUbiquitin-protein ligase E3Cprotein polyubiquitination6ubiquitin-protein transferase activity,protein binding(proteasome complex,intracellular,nucleus^>sp|Q15386|UBE3C_HUMAN Ubiquitin-protein ligase E3C OS=Homo sapiens OX=9606 GN=UBE3C PE=1 SV=3P05546SERPIND1 HEP2_HUMANHeparin cofactor 2Zchemotaxis,blood coagulation,bioluminescence,negative regulation of endopeptidase activity]endopeptidase inhibitor activity,serine-type endopeptidase inhibitor activity,heparin binding>extracellular region,extracellular space,extracellular exosomeV>sp|P05546|HEP2_HUMAN Heparin cofactor 2 OS=Homo sapiens OX=9606 GN=SERPIND1 PE=1 SV=3P32754HPD HPPD_HUMAN#4-hydroxyphenylpyruvate dioxygenaseXL-phenylalanine catabolic process,tyrosine catabolic process,oxidation-reduction process>4-hydroxyphenylpyruvate dioxygenase activity,metal ion bindingKGolgi membrane,endoplasmic reticulum membrane,cytosol,extracellular exosomeb>sp|P32754|HPPD_HUMAN 4-hydroxyphenylpyruvate dioxygenase OS=Homo sapiens OX=9606 GN=HPD PE=1 SV=2Q14232EIF2B1 EI2BA_HUMAN2Translation initiation factor eIF-2B subunit alphatranslational initiation,response to heat,response to glucose,oligodendrocyte development,response to peptide hormone,positive regulation of GTPase activity,cellular response to stimulus{protein binding,identical protein binding,translation initiation factor activity,guanyl-nucleotide exchange factor activity^cytoplasm,cytosol,eukaryotic translation initiation factor 2B complex,plasma membrane,membraneu>sp|Q14232|EI2BA_HUMAN Translation initiation factor eIF-2B subunit alpha OS=Homo sapiens OX=9606 GN=EIF2B1 PE=1 SV=1P00568AK1 KAD1_HUMANAdenylate kinase isoenzyme 1nucleoside diphosphate phosphorylation,nucleoside triphosphate biosynthetic process,nucleobase-containing small molecule interconversion,ATP metabolic processLadenylate kinase activity,nucleoside diphosphate kinase activity,ATP binding[>sp|P00568|KAD1_HUMAN Adenylate kinase isoenzyme 1 OS=Homo sapiens OX=9606 GN=AK1 PE=1 SV=3O00764PDXK PDXK_HUMANPyridoxal kinasecell proliferation,pyridoxal 5'-phosphate salvage,phosphorylation,vitamin B6 metabolic process,pyridoxal phosphate biosynthetic process,neutrophil degranulationmagnesium ion binding,ATP binding,zinc ion binding,pyridoxal kinase activity,pyridoxal phosphate binding,potassium ion binding,sodium ion binding,lithium ion binding,protein homodimerization activityiextracellular region,nucleus,cytosol,secretory granule lumen,specific granule lumen,extracellular exosomeP>sp|O00764|PDXK_HUMAN Pyridoxal kinase OS=Homo sapiens OX=9606 GN=PDXK PE=1 SV=1P23219PTGS1 PGH1_HUMANProstaglandin G/H synthase 1prostaglandin biosynthetic process,lipid metabolic process,xenobiotic metabolic process,inflammatory response,response to oxidative stress,regulation of blood pressure,cyclooxygenase pathway,regulation of cell proliferation,oxidation-reduction process,cellular oxidant detoxificationtperoxidase activity,prostaglandin-endoperoxide synthase activity,heme binding,metal ion binding,dioxygenase activityphotoreceptor outer segment,nucleus,cytoplasm,endoplasmic reticulum membrane,Golgi apparatus,organelle membrane,intracellular membrane-bounded organelle,extracellular exosome]>sp|P23219|PGH1_HUMAN Prostaglandin G/H synthase 1 OS=Homo sapiens OX=9606 GN=PTGS1 PE=1 SV=2Q16543CDC37 CDC37_HUMANHsp90 co-chaperone Cdc37regulation of cyclin-dependent protein serine/threonine kinase activity,protein folding,protein targeting,posttranscriptional regulation of gene expression,peptidyl-tyrosine phosphorylation,ERBB2 signaling pathway,protein stabilization,regulation of interferon-gamma-mediated signaling pathway,regulation of type I interferon-mediated signaling pathway,mitophagy in response to mitochondrial depolarizationprotein tyrosine kinase activity,protein binding,protein kinase regulator activity,kinase binding,protein kinase binding,heat shock protein binding,unfolded protein binding,chaperone binding,Hsp90 protein bindingEcytoplasm,cytosol,extracellular exosome,HSP90-CDC37 chaperone complexZ>sp|Q16543|CDC37_HUMAN Hsp90 co-chaperone Cdc37 OS=Homo sapiens OX=9606 GN=CDC37 PE=1 SV=1P22352GPX3 GPX3_HUMANGlutathione peroxidase 3response to reactive oxygen species,response to lipid hydroperoxide,hydrogen peroxide catabolic process,protein homotetramerization,oxidation-reduction process,cellular oxidant detoxification]glutathione peroxidase activity,protein binding,transcription factor binding,selenium bindingX>sp|P22352|GPX3_HUMAN Glutathione peroxidase 3 OS=Homo sapiens OX=9606 GN=GPX3 PE=1 SV=2P62857RPS28 RS28_HUMAN40S ribosomal protein S287ribosomal small subunit assembly,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,viral transcription,maturation of SSU-rRNA,ribosome biogenesis,ribosomal small subunit biogenesiscnucleoplasm,cytosol,small ribosomal subunit,cytosolic small ribosomal subunit,extracellular exosomeZ>sp|P62857|RS28_HUMAN 40S ribosomal protein S28 OS=Homo sapiens OX=9606 GN=RPS28 PE=1 SV=1Q14558PRPSAP1 KPRA_HUMAN:Phosphoribosyl pyrophosphate synthase-associated protein 1znucleobase-containing compound metabolic proc< ess,nucleotide biosynthetic process,negative regulation of catalytic activitymagnesium ion binding,ribose phosphate diphosphokinase activity,enzyme inhibitor activity,protein binding,identical protein binding}>sp|Q14558|KPRA_HUMAN Phosphoribosyl pyrophosphate synthase-associated protein 1 OS=Homo sapiens OX=9606 GN=PRPSAP1 PE=1 SV=2Q13098GPS1 CSN1_HUMAN"COP9 signalosome complex subunit 1inactivation of MAPK activity,protein deneddylation,nucleotide-excision repair, DNA damage recognition,transcription-coupled nucleotide-excision repair,cell cycle,JNK cascade,negative regulation of GTPase activity)GTPase inhibitor activity,protein binding$nucleoplasm,cytosol,COP9 signalosomeb>sp|Q13098|CSN1_HUMAN COP9 signalosome complex subunit 1 OS=Homo sapiens OX=9606 GN=GPS1 PE=1 SV=4P24530EDNRB EDNRB_HUMANEndothelin receptor type B.negative regulation of transcription from RNA polymerase II promoter,neural crest cell migration,positive regulation of protein phosphorylation,regulation of pH,cell surface receptor signaling pathway,negative regulation of adenylate cyclase activity,phospholipase C-activating G-protein coupled receptor signaling pathway,positive regulation of cytosolic calcium ion concentration,nervous system development,peripheral nervous system development,posterior midgut development,aging,regulation of blood pressure,positive regulation of cell proliferation,negative regulation of neuron maturation,response to organic cyclic compound,vein smooth muscle contraction,sensory perception of pain,cGMP-mediated signaling,melanocyte differentiation,regulation of fever generation,negative regulation of cellular protein metabolic process,enteric smooth muscle cell differentiation,positive regulation of urine volume,positive regulation of renal sodium excretion,epithelial fluid transport,vasoconstriction,vasodilation,negative regulation of apoptotic process,macrophage chemotaxis,response to pain,enteric nervous system development,regulation of epithelial cell proliferation,regulation of sensory perception of pain,positive regulation of penile erection,cellular response to lipopolysaccharide,endothelin receptor signaling pathwayhendothelin receptor activity,protein binding,peptide hormone binding,type 1 angiotensin receptor bindingTplasma membrane,integral component of plasma membrane,nuclear membrane,membrane raft\>sp|P24530|EDNRB_HUMAN Endothelin receptor type B OS=Homo sapiens OX=9606 GN=EDNRB PE=1 SV=1P02753RBP4 RET4_HUMANRetinol-binding protein 4retinoid metabolic process,eye development,gluconeogenesis,heart development,visual perception,maintenance of gastrointestinal epithelium,lung development,positive regulation of insulin secretion,response to retinoic acid,retinol transport,retinol metabolic process,glucose homeostasis,response to ethanol,embryonic organ morphogenesis,embryonic skeletal system development,cardiac muscle tissue development,female genitalia morphogenesis,positive regulation of immunoglobulin secretion,negative regulation of cardiac muscle cell proliferation,embryonic retina morphogenesis in camera-type eye,uterus development,vagina development,urinary bladder development,heart trabecula formationpprotein binding,retinal binding,retinol binding,retinol transporter activity,protein heterodimerization activityVextracellular region,extracellular space,cytosol,protein complex,extracellular exosomeY>sp|P02753|RET4_HUMAN Retinol-binding protein 4 OS=Homo sapiens OX=9606 GN=RBP4 PE=1 SV=3Q99653CHP1 CHP1_HUMAN"Calcineurin B homologous protein 1microtubule bundle formation,negative regulation of protein phosphorylation,negative regulation of protein kinase activity,protein export from nucleus,potassium ion transport,small GTPase mediated signal transduction,negative regulation of phosphatase activity,calcium ion regulated exocytosis,membrane docking,hyaluronan catabolic process,cytoplasmic microtubule organization,negative regulation of protein ubiquitination,negative regulation of protein autophosphorylation,negative regulation of NF-kappaB transcription factor activity,positive regulation of sodium:proton antiporter activity,negative regulation of protein import into nucleus,protein stabilization,positive regulation of protein transport,protein oligomerization,regulation of intracellular pH,positive regulation of protein glycosylation,membrane organization,membrane fusion,negative regulation of calcineurin-NFAT signaling cascade,cellular response to acidic pH,positive regulation of protein targeting to membrane,regulation of neuron deathprotein kinase inhibitor activity,transporter activity,calcium ion binding,protein binding,microtubule binding,potassium channel regulator activity,kinase binding,calcium-dependent protein bindingGolgi membrane,nucleus,cytoplasm,endoplasmic reticulum,endoplasmic reticulum-Golgi intermediate compartment,cytosol,plasma membrane,focal adhesion,microtubule cytoskeleton,transport vesicle,extracellular exosomeb>sp|Q99653|CHP1_HUMAN Calcineurin B homologous protein 1 OS=Homo sapiens OX=9606 GN=CHP1 PE=1 SV=3Q9ULF5SLC39A10 S39AA_HUMANZinc transporter ZIP10negative regulation of B cell apoptotic process,cellular zinc ion homeostasis,positive regulation of B cell proliferation,positive regulation of B cell receptor signaling pathway,zinc II ion transmembrane import,positive regulation of protein tyrosine phosphatase activity+zinc ion transmembrane transporter activity[>sp|Q9ULF5|S39AA_HUMAN Zinc transporter ZIP10 OS=Homo sapiens OX=9606 GN=SLC39A10 PE=1 SV=2Q9UNH7SNX6 SNX6_HUMANSorting nexin-6intracellular protein transport,endocytosis,negative regulation of epidermal growth factor-activated receptor activity,vesicle organization,regulation of macroautophagy,negative regulation of transforming growth factor beta receptor signaling pathway,retrograde transport, endosome to Golgi,negative regulation of transcription, DNA-templated,regulation of histamine secretion by mast cellprotein binding,dynactin binding,phosphatidylinositol binding,protein homodimerization activity,protein heterodimerization activityintracellular,nucleus,cytoplasm,cytosol,extrinsic component of membrane,retromer complex,retromer, tubulation complex,early endosome membrane,tubular endosomeO>sp|Q9UNH7|SNX6_HUMAN Sorting nexin-6 OS=Homo sapiens OX=9606 GN=SNX6 PE=1 SV=1Q9NPH3IL1RAP IL1AP_HUMAN(Interleukin-1 receptor accessory proteinprotein complex assembly,inflammatory response,immune response,positive regulation of interleukin-13 production,positive regulation of interleukin-5 production,interleukin-33-mediated signaling pathway,interleukin-2 biosynthetic process,innate immune response,positive regulation of NF-kappaB transcription factor activity,positive regulation of synapse assembly,interleukin-4 secretion,positive regulation of dendrite development,positive regulation of interleukin-6 secretion{interleukin-33 receptor activity,signal transducer activity,interleukin-1 receptor activity,protein tyrosine kinase bindingRextracellular space,plasma membrane,integral component of plasma membrane,membranek>sp|Q9NPH3|IL1AP_HUMAN Interleukin-1 receptor accessory protein OS=Homo sapiens OX=9606 GN=IL1RAP PE=1 SV=2Q9H9H4VPS37B VP37B_HUMAN/Vacuolar protein sorting-associated protein 37Bprotein transport,endosomal transport,macroautophagy,viral life cycle,multivesicular body assembly,viral budding via host ESCRT complex,intracellular transport of virus,positive regulation of viral release from host cell,positive regulation of viral budding via host ESCRT complex1protein binding,calcium-dependent protein bindingyESCRT I complex,cytoplasm,endosome,plasma membrane,endosome membrane,midbody,late endosome membrane,extracellular exosomer>sp|Q9H9H4|VP37B_HUMAN Vacuolar protein sorting-associated protein 37B OS=Homo sapiens OX=9606 GN=VPS37B PE=1 SV=1P20645M6PR MPRD_HUMAN-Cation-dependent mannose-6-phosphate receptorreceptor-mediated endocytosis,signal transduction,endosome to lysosome transport,mannose transport,secretion of lysosomal enzymes,membrane organizationtransmembrane signaling receptor activity,pr< otein binding,mannose binding,mannose transmembrane transporter activity,retromer complex bindinglysosomal membrane,endosome,late endosome,plasma membrane,integral component of plasma membrane,membrane,transport vesicle,clathrin-coated vesicle membrane,trans-Golgi network membrane,perinuclear region of cytoplasm,retromer complexm>sp|P20645|MPRD_HUMAN Cation-dependent mannose-6-phosphate receptor OS=Homo sapiens OX=9606 GN=M6PR PE=1 SV=1Q96T76MMS19 MMS19_HUMAN0MMS19 nucleotide excision repair protein homolog%phosphorelay signal transduction system,DNA metabolic process,DNA repair,nucleotide-excision repair,transcription, DNA-templated,cellular response to DNA damage stimulus,chromosome segregation,response to hormone,iron-sulfur cluster assembly,positive regulation of transcription, DNA-templatedtranscription coactivator activity,protein binding,enzyme binding,receptor signaling complex scaffold activity,estrogen receptor binding,protein binding, bridgingbnucleus,nucleoplasm,holo TFIIH complex,cytoplasm,spindle,cytosol,membrane,MMXD complex,CIA complexr>sp|Q96T76|MMS19_HUMAN MMS19 nucleotide excision repair protein homolog OS=Homo sapiens OX=9606 GN=MMS19 PE=1 SV=2Q9UHV9PFDN2 PFD2_HUMANPrefoldin subunit 2@protein folding,positive regulation of cytoskeleton organizationTprotein binding,protein binding involved in protein folding,unfolded protein bindingOnucleus,cytoplasm,mitochondrion,cytosol,prefoldin complex,extracellular exosomeT>sp|Q9UHV9|PFD2_HUMAN Prefoldin subunit 2 OS=Homo sapiens OX=9606 GN=PFDN2 PE=1 SV=1O75368SH3BGRL SH3L1_HUMAN2SH3 domain-binding glutamic acid-rich-like protein*positive regulation of signal transduction+SH3/SH2 adaptor activity,SH3 domain binding;extracellular space,nucleus,cytoplasm,extracellular exosomev>sp|O75368|SH3L1_HUMAN SH3 domain-binding glutamic acid-rich-like protein OS=Homo sapiens OX=9606 GN=SH3BGRL PE=1 SV=1Q7Z4F1LRP10 LRP10_HUMAN3Low-density lipoprotein receptor-related protein 10[lipid metabolic process,lipid transport,receptor-mediated endocytosis,inner ear development)low-density lipoprotein receptor activity;clathrin-coated pit,membrane,integral component of membraneu>sp|Q7Z4F1|LRP10_HUMAN Low-density lipoprotein receptor-related protein 10 OS=Homo sapiens OX=9606 GN=LRP10 PE=1 SV=2 Q9NUU7;Q9UMR2 DDX19A;DDX19BDD19A_HUMAN;DD19B_HUMANCATP-dependent RNA helicase DDX19A;ATP-dependent RNA helicase DDX19Bbiological_process,RNA splicing,regulation of gene expression,RNA secondary structure unwinding,protein transport,mRNA transport;mRNA export from nucleus,RNA splicing,regulation of gene expression,RNA secondary structure unwindingmolecular_function,RNA binding,ATP-dependent RNA helicase activity,protein binding,ATP binding;RNA binding,ATP-dependent RNA helicase activity,helicase activity,protein binding,ATP bindingnuclear pore,cytoplasm,membrane,nuclear membrane,catalytic step 2 spliceosome;nuclear pore,cytoplasm,membrane,nuclear membrane,extracellular exosome,catalytic step 2 spliceosome>sp|Q9NUU7|DD19A_HUMAN ATP-dependent RNA helicase DDX19A OS=Homo sapiens OX=9606 GN=DDX19A PE=1 SV=1;>sp|Q9UMR2|DD19B_HUMAN ATP-dependent RNA helicase DDX19B OS=Homo sapiens OX=9606 GN=DDX19B PE=1 SV=1Q8IUR7ARMC8 ARMC8_HUMAN%Armadillo repeat-containing protein 8Bextracellular region,specific granule lumen,tertiary granule lumeng>sp|Q8IUR7|ARMC8_HUMAN Armadillo repeat-containing protein 8 OS=Homo sapiens OX=9606 GN=ARMC8 PE=1 SV=2P30740SERPINB1 ILEU_HUMANLeukocyte elastase inhibitorFnegative regulation of endopeptidase activity,neutrophil degranulation,serine-type endopeptidase inhibitor activity_extracellular region,extracellular space,membrane,secretory granule lumen,extracellular exosome`>sp|P30740|ILEU_HUMAN Leukocyte elastase inhibitor OS=Homo sapiens OX=9606 GN=SERPINB1 PE=1 SV=1P61916NPC2 NPC2_HUMAN+NPC intracellular cholesterol transporter 2Areceptor-mediated endocytosis,cholesterol metabolic process,response to virus,phospholipid transport,regulation of isoprenoid metabolic process,cholesterol transport,intracellular sterol transport,intracellular cholesterol transport,cholesterol efflux,cholesterol homeostasis,neutrophil degranulation,glycolipid transport2protein binding,cholesterol binding,enzyme bindingextracellular region,extracellular space,lysosome,endoplasmic reticulum,azurophil granule lumen,lysosomal lumen,extracellular exosomek>sp|P61916|NPC2_HUMAN NPC intracellular cholesterol transporter 2 OS=Homo sapiens OX=9606 GN=NPC2 PE=1 SV=1Q7Z5G4GOLGA7 GOGA7_HUMANGolgin subfamily A member 7protein targeting to membrane,peptidyl-L-cysteine S-palmitoylation,Golgi to plasma membrane protein transport,neutrophil degranulation,protein stabilization@protein binding,protein-cysteine S-palmitoyltransferase activitypalmitoyltransferase complex,extracellular region,Golgi stack,intrinsic component of Golgi membrane,extracellular exosome,tertiary granule lumen^>sp|Q7Z5G4|GOGA7_HUMAN Golgin subfamily A member 7 OS=Homo sapiens OX=9606 GN=GOLGA7 PE=1 SV=2Q9UHB9SRP68 SRP68_HUMAN)Signal recognition particle subunit SRP68dSRP-dependent cotranslational protein targeting to membrane,response to drug,protein targeting to ER{RNA binding,signal recognition particle binding,protein binding,7S RNA binding,endoplasmic reticulum signal peptide binding|nucleolus,endoplasmic reticulum,signal recognition particle, endoplasmic reticulum targeting,cytosol,ribosome,focal adhesionk>sp|Q9UHB9|SRP68_HUMAN Signal recognition particle subunit SRP68 OS=Homo sapiens OX=9606 GN=SRP68 PE=1 SV=2O95445APOM APOM_HUMANApolipoprotein Mvretinoid metabolic process,response to glucose,cholesterol efflux,high-density lipoprotein particle remodeling,high-density lipoprotein particle assembly,high-density lipoprotein particle clearance,negative regulation of plasma lipoprotein particle oxidation,lipoprotein metabolic process,cholesterol homeostasis,reverse cholesterol transport,cellular oxidant detoxificationDlipid transporter activity,phospholipid binding,antioxidant activityextracellular region,integral component of plasma membrane,very-low-density lipoprotein particle,low-density lipoprotein particle,high-density lipoprotein particle,discoidal high-density lipoprotein particle,spherical high-density lipoprotein particle,extracellular exosomeP>sp|O95445|APOM_HUMAN Apolipoprotein M OS=Homo sapiens OX=9606 GN=APOM PE=1 SV=2O43324EEF1E1 MCA3_HUMAN4Eukaryotic translation elongation factor 1 epsilon-1tRNA aminoacylation for protein translation,negative regulation of cell proliferation,positive regulation of apoptotic process,positive regulation of DNA damage response, signal transduction by p53 class mediator,positive regulation of cellular senescenceEnucleus,nucleoplasm,nucleolus,cytoplasm,cytosol,extracellular exosomev>sp|O43324|MCA3_HUMAN Eukaryotic translation elongation factor 1 epsilon-1 OS=Homo sapiens OX=9606 GN=EEF1E1 PE=1 SV=1P46783RPS10 RS10_HUMAN40S ribosomal protein S10ribosomal small subunit assembly,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,viral transcriptionnucleoplasm,nucleolus,cytosol,ribosome,focal adhesion,membrane,cytosolic small ribosomal subunit,extracellular matrix,extracellular exosomeZ>sp|P46783|RS10_HUMAN 40S ribosomal protein S10 OS=Homo sapiens OX=9606 GN=RPS10 PE=1 SV=1Q9NR45NANS SIAS_HUMANSialic acid synthase'lipopolysaccharide biosynthetic processN-acylneuraminate cytidylyltransferase activity,N-acylneuraminate-9-phosphate synthase activity,N-acetylneuraminate synthase activity'cytoplasm,cytosol,extracellular exosomeT>sp|Q9NR45|SIAS_HUMAN Sialic acid synthase OS=Homo sapiens OX=9606 GN=NANS PE=1 SV=2Q9P0V3SH3BP4 SH3B4_HUMANSH3 domain-binding protein 4Bendocytosis,negative regulation of cell proliferation,positive regulation of autophagy,negative regulation of cell growth,negative regulation of TOR signaling,negative regulation of GTPase activity< ,regulation of catalytic activity,protein localization to lysosome,cellular response to amino acid stimulus,amino acid import`GDP-dissociation inhibitor activity,protein binding,Ras GTPase binding,identical protein bindingSnucleus,cytoplasm,clathrin-coated pit,clathrin-coated vesicle,extracellular exosome_>sp|Q9P0V3|SH3B4_HUMAN SH3 domain-binding protein 4 OS=Homo sapiens OX=9606 GN=SH3BP4 PE=1 SV=1O14494PLPP1 PLPP1_HUMANPhospholipid phosphatase 1protein dephosphorylation,lipid metabolic process,phospholipid metabolic process,protein kinase C-activating G-protein coupled receptor signaling pathway,negative regulation of cell proliferation,germ cell migration,regulation of lipid metabolic process,sphingolipid biosynthetic process,intracellular steroid hormone receptor signaling pathway,androgen receptor signaling pathway,phospholipid dephosphorylationjphosphatidate phosphatase activity,sphingosine-1-phosphate phosphatase activity,lipid phosphatase activityTplasma membrane,integral component of plasma membrane,membrane,extracellular exosome\>sp|O14494|PLPP1_HUMAN Phospholipid phosphatase 1 OS=Homo sapiens OX=9606 GN=PLPP1 PE=1 SV=1P48059LIMS1 LIMS1_HUMAN?LIM and senescent cell antigen-like-containing domain protein 1cell aging,positive regulation of gene expression,positive regulation of cell-substrate adhesion,cell junction assembly,positive regulation of GTPase activity,establishment of protein localization,negative regulation of transcription, DNA-templated,positive regulation of focal adhesion assembly,cellular response to transforming growth factor beta stimulus,positive regulation of substrate adhesion-dependent cell spreading,epithelial to mesenchymal transition,regulation of epithelial cell proliferation7protein binding,zinc ion binding,protein kinase bindingYcytosol,plasma membrane,cell-cell junction,focal adhesion,perinuclear region of cytoplasm>sp|P48059|LIMS1_HUMAN LIM and senescent cell antigen-like-containing domain protein 1 OS=Homo sapiens OX=9606 GN=LIMS1 PE=1 SV=4Q9H479FN3K FN3K_HUMANFructosamine-3-kinasephosphorylation,fructosamine metabolic process,fructoselysine metabolic process,epithelial cell differentiation,post-translational protein modification.kinase activity,fructosamine-3-kinase activitycellular_component,cytosolU>sp|Q9H479|FN3K_HUMAN Fructosamine-3-kinase OS=Homo sapiens OX=9606 GN=FN3K PE=1 SV=1O60831PRAF2 PRAF2_HUMANPRA1 family protein 2'protein transport,L-glutamate transport0endosome membrane,integral component of membraneW>sp|O60831|PRAF2_HUMAN PRA1 family protein 2 OS=Homo sapiens OX=9606 GN=PRAF2 PE=1 SV=1O14744PRMT5 ANM5_HUMAN&Protein arginine N-methyltransferase 5 spliceosomal snRNP assembly,DNA-templated transcription, termination,regulation of transcription, DNA-templated,regulation of mitotic nuclear division,cell proliferation,peptidyl-arginine methylation,peptidyl-arginine methylation, to symmetrical-dimethyl arginine,circadian regulation of gene expression,peptidyl-arginine N-methylation,endothelial cell activation,histone H4-R3 methylation,regulation of DNA methylation,negative regulation of cell differentiation,positive regulation of oligodendrocyte differentiation,regulation of ERK1 and ERK2 cascade,Golgi ribbon formation,liver regeneration,regulation of signal transduction by p53 class mediator,negative regulation of nucleic acid-templated transcription,positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathwaycore promoter sequence-specific DNA binding,transcription corepressor activity,protein binding,methyltransferase activity,methyl-CpG binding,histone-arginine N-methyltransferase activity,protein-arginine N-methyltransferase activity,protein complex binding,protein-arginine omega-N symmetric methyltransferase activity,ribonucleoprotein complex binding,histone methyltransferase activity (H4-R3 specific),protein heterodimerization activitysnucleus,nucleoplasm,cytoplasm,Golgi apparatus,cytosol,methylosome,histone methyltransferase complex,protein complexg>sp|O14744|ANM5_HUMAN Protein arginine N-methyltransferase 5 OS=Homo sapiens OX=9606 GN=PRMT5 PE=1 SV=4P35080PFN2 PROF2_HUMAN Profilin-2negative regulation of epithelial cell migration,actin cytoskeleton organization,negative regulation of actin filament polymerization,positive regulation of actin filament polymerization,positive regulation of actin filament bundle assembly,positive regulation of ATPase activity,positive regulation of peptidyl-serine phosphorylation,protein stabilization,positive regulation of stress fiber assembly,negative regulation of ruffle assembly,regulation of synaptic vesicle exocytosis~adenyl-nucleotide exchange factor activity,actin monomer binding,protein binding,phosphatidylinositol-4,5-bisphosphate binding<cytoplasm,cytoskeleton,terminal bouton,extracellular exosomeK>sp|P35080|PROF2_HUMAN Profilin-2 OS=Homo sapiens OX=9606 GN=PFN2 PE=1 SV=3Q96RF0SNX18 SNX18_HUMANSorting nexin-18mitotic cytokinesis,endocytosis,mitotic nuclear division,protein transport,endosomal transport,cleavage furrow formation,positive regulation of GTPase activity=protein binding,phosphatidylinositol-4,5-bisphosphate bindingendosome membrane,cytoplasmic vesicle membrane,extrinsic component of cytoplasmic side of plasma membrane,cytoplasmic vesicle,extracellular exosome,clathrin-coated vesicleR>sp|Q96RF0|SNX18_HUMAN Sorting nexin-18 OS=Homo sapiens OX=9606 GN=SNX18 PE=1 SV=2P12643BMP2 BMP2_HUMANBone morphogenetic protein 2Dnegative regulation of transcription from RNA polymerase II promoter,activation of MAPK activity,skeletal system development,osteoblast differentiation,branching involved in ureteric bud morphogenesis,response to hypoxia,in utero embryonic development,epithelial to mesenchymal transition,positive regulation of protein phosphorylation,positive regulation of endothelial cell proliferation,chondrocyte differentiation,BMP signaling pathway involved in heart induction,atrioventricular valve morphogenesis,endocardial cushion morphogenesis,negative regulation of Wnt signaling pathway involved in heart development,proteoglycan metabolic process,regulation of transcription, DNA-templated,protein phosphorylation,inflammatory response,Notch signaling pathway,cell-cell signaling,heart development,negative regulation of cell proliferation,embryo development,animal organ morphogenesis,positive regulation of gene expression,positive regulation of epithelial to mesenchymal transition,positive regulation of pathway-restricted SMAD protein phosphorylation,negative regulation of steroid biosynthetic process,positive regulation of phosphatase activity,telencephalon development,telencephalon regionalization,positive regulation of Wnt signaling pathway,bone mineralization,positive regulation of cell migration,positive regulation of bone mineralization,BMP signaling pathway,protein destabilization,positive regulation of protein binding,negative regulation of aldosterone biosynthetic process,positive regulation of osteoblast proliferation,cardiocyte differentiation,embryonic heart tube anterior/posterior pattern specification,bone mineralization involved in bone maturation,odontogenesis of dentin-containing tooth,positive regulation of odontogenesis,regulation of odontogenesis of dentin-containing tooth,positive regulation of apoptotic process,positive regulation of MAPK cascade,negative regulation of insulin-like growth factor receptor signaling pathway,cell fate commitment,positive regulation of fat cell differentiation,positive regulation of neuron differentiation,positive regulation of osteoblast differentiation,positive regulation of ossification,negative regulation of cell cycle,negative regulation of transcription, DNA-templated,positive regulation of transcription, DNA-templated,positive regulation of transcription from RNA polymerase II promoter,cell development,positive regulation of astrocyte differentiation,mesenchymal cell differentiation,inner ear development,negative regulation of calcium-independent cell-cell adhesion,cardiac muscle cell differentiation,cardiac muscle tissue m< orphogenesis,oxidation-reduction process,pericardium development,corticotropin hormone secreting cell differentiation,thyroid-stimulating hormone-secreting cell differentiation,cardiac epithelial to mesenchymal transition,pathway-restricted SMAD protein phosphorylation,SMAD protein signal transduction,mesenchyme development,positive regulation of Wnt signaling pathway by BMP signaling pathway,positive regulation of cartilage development,positive regulation of ERK1 and ERK2 cascade,cellular response to organic cyclic compound,cellular response to BMP stimulus,mesenchymal cell proliferation involved in ureteric bud development,negative regulation of canonical Wnt signaling pathway,positive regulation of p38MAPK cascade,positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus,positive regulation of pri-miRNA transcription from RNA polymerase II promoter,negative regulation of cortisol biosynthetic process,negative regulation of cardiac muscle cell differentiationretinol dehydrogenase activity,receptor binding,cytokine activity,transforming growth factor beta receptor binding,protein binding,growth factor activity,phosphatase activator activity,co-receptor binding,SMAD binding,protein heterodimerization activity,BMP receptor bindingsextracellular region,extracellular space,cell surface,intracellular membrane-bounded organelle,BMP receptor complex\>sp|P12643|BMP2_HUMAN Bone morphogenetic protein 2 OS=Homo sapiens OX=9606 GN=BMP2 PE=1 SV=1Q9NTK5OLA1 OLA1_HUMANObg-like ATPase 1,platelet degranulation,ATP metabolic processZprotein binding,ATP binding,GTP binding,ATPase activity,cadherin binding,metal ion bindingwextracellular region,nucleolus,cytoplasm,centrosome,cytosol,membrane,platelet alpha granule lumen,extracellular exosomeQ>sp|Q9NTK5|OLA1_HUMAN Obg-like ATPase 1 OS=Homo sapiens OX=9606 GN=OLA1 PE=1 SV=2Q15233NONO NONO_HUMAN1Non-POU domain-containing octamer-binding proteinamRNA splicing, via spliceosome,DNA repair,DNA recombination,transcription, DNA-templated,regulation of transcription, DNA-templated,mRNA processing,circadian rhythm,RNA splicing,regulation of circadian rhythm,negative regulation of transcription, DNA-templated,negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathwaynucleotide binding,transcription regulatory region sequence-specific DNA binding,RNA polymerase II distal enhancer sequence-specific DNA binding,core promoter binding,chromatin binding,RNA binding,protein binding,identical protein bindingnucleus,nucleoplasm,nucleolus,membrane,nuclear matrix,nuclear speck,paraspeckles,RNA polymerase II transcription factor complexq>sp|Q15233|NONO_HUMAN Non-POU domain-containing octamer-binding protein OS=Homo sapiens OX=9606 GN=NONO PE=1 SV=4 P61254;Q9UNX3 RPL26;RPL26L1RL26_HUMAN;RL26L_HUMAN:60S ribosomal protein L26;60S ribosomal protein L26-like 1nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,viral transcription,ribosomal large subunit biogenesis;translationaRNA binding,structural constituent of ribosome,protein binding;structural constituent of ribosomevcytosol,membrane,cytosolic large ribosomal subunit,extracellular exosome;large ribosomal subunit,extracellular exosome>sp|P61254|RL26_HUMAN 60S ribosomal protein L26 OS=Homo sapiens OX=9606 GN=RPL26 PE=1 SV=1;>sp|Q9UNX3|RL26L_HUMAN 60S ribosomal protein L26-like 1 OS=Homo sapiens OX=9606 GN=RPL26L1 PE=1 SV=1Q9BT67NDFIP1 NFIP1_HUMAN"NEDD4 family-interacting protein 1regulation of myeloid leukocyte differentiation,negative regulation of type 2 immune response,cellular iron ion homeostasis,vacuolar transport,signal transduction,negative regulation of gene expression,metal ion transport,positive regulation of protein ubiquitination,negative regulation of transporter activity,negative regulation of interleukin-4 production,negative regulation of T cell proliferation,positive regulation of I-kappaB kinase/NF-kappaB signaling,regulation of lymphocyte differentiation,positive regulation of protein catabolic process,negative regulation of isotype switching to IgE isotypes,regulation of isotype switching to IgG isotypes,negative regulation of inflammatory response,negative regulation of protein transport*signal transducer activity,protein bindingGolgi membrane,extracellular region,cell cortex,endosome membrane,integral component of membrane,perinuclear region of cytoplasme>sp|Q9BT67|NFIP1_HUMAN NEDD4 family-interacting protein 1 OS=Homo sapiens OX=9606 GN=NDFIP1 PE=1 SV=1P06732CKM KCRM_HUMANCreatine kinase M-typeOcreatine metabolic process,phosphorylation,phosphocreatine biosynthetic process4creatine kinase activity,protein binding,ATP bindingU>sp|P06732|KCRM_HUMAN Creatine kinase M-type OS=Homo sapiens OX=9606 GN=CKM PE=1 SV=2P68133ACTA1 ACTS_HUMANActin, alpha skeletal muscleSmuscle contraction,response to mechanical stimulus,response to extracellular stimulus,response to lithium ion,positive regulation of gene expression,cell growth,muscle filament sliding,skeletal muscle thin filament assembly,skeletal muscle fiber adaptation,response to steroid hormone,skeletal muscle fiber development,mesenchyme migration]structural constituent of cytoskeleton,protein binding,ATP binding,myosin binding,ADP bindingstress fiber,extracellular space,cytosol,striated muscle thin filament,actin filament,actin cytoskeleton,sarcomere,lamellipodium,filopodium,cell body,extracellular exosome,blood microparticle]>sp|P68133|ACTS_HUMAN Actin, alpha skeletal muscle OS=Homo sapiens OX=9606 GN=ACTA1 PE=1 SV=1Q13510ASAH1 ASAH1_HUMANAcid ceramidaseWceramide metabolic process,glycosphingolipid metabolic process,neutrophil degranulation&catalytic activity,ceramidase activityextracellular region,extracellular space,lysosomal lumen,extracellular exosome,tertiary granule lumen,ficolin-1-rich granule lumenQ>sp|Q13510|ASAH1_HUMAN Acid ceramidase OS=Homo sapiens OX=9606 GN=ASAH1 PE=1 SV=5Q9NQX7ITM2C ITM2C_HUMANIntegral membrane protein 2Cnegative regulation of neuron projection development,neuron differentiation,positive regulation of extrinsic apoptotic signaling pathway0beta-amyloid binding,protein binding,ATP bindinglysosome,lysosomal membrane,Golgi apparatus,plasma membrane,integral component of membrane,perinuclear region of cytoplasm,extracellular exosome^>sp|Q9NQX7|ITM2C_HUMAN Integral membrane protein 2C OS=Homo sapiens OX=9606 GN=ITM2C PE=1 SV=1Q13310PABPC4 PABP4_HUMANPolyadenylate-binding protein 4BRNA processing,RNA catabolic process,translation,blood coagulationfnucleotide binding,RNA binding,protein binding,poly(A) binding,poly(U) RNA binding,poly(C) RNA binding\nucleus,cytoplasm,cytosol,cytoplasmic stress granule,intracellular ribonucleoprotein complexb>sp|Q13310|PABP4_HUMAN Polyadenylate-binding protein 4 OS=Homo sapiens OX=9606 GN=PABPC4 PE=1 SV=1P26196DDX6 DDX6_HUMAN(Probable ATP-dependent RNA helicase DDX6Cregulation of translation,spermatogenesis,RNA secondary structure unwinding,viral RNA genome packaging,stem cell population maintenance,cytoplasmic mRNA processing body assembly,exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay,negative regulation of neuron differentiationRNA binding,RNA helicase activity,ATP-dependent RNA helicase activity,helicase activity,protein binding,ATP binding,protein domain specific binding,cadherin bindingheterochromatin,cytoplasmic mRNA processing body,outer dense fiber,nucleus,nucleolus,cytoplasm,mitochondrion,cytosol,cytoplasmic stress granule,membrane,RISC complex,P granule,sperm annulush>sp|P26196|DDX6_HUMAN Probable ATP-dependent RNA helicase DDX6 OS=Homo sapiens OX=9606 GN=DDX6 PE=1 SV=2Q16706MAN2A1 MA2A1_HUMANAlpha-mannosidase 2?in utero embryonic development,liver development,mannose metabolic process,protein glycosylation,N-glycan processing,protein deglycosylation,mitochondrion organization,vacuole organi< zation,respiratory gaseous exchange,lung alveolus development,positive regulation of neurogenesis,retina morphogenesis in camera-type eyealpha-mannosidase activity,mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity,zinc ion binding,hydrolase activity, hydrolyzing N-glycosyl compounds,carbohydrate bindingrGolgi membrane,extracellular space,cis-Golgi network,membrane,integral component of membrane,extracellular exosomeV>sp|Q16706|MA2A1_HUMAN Alpha-mannosidase 2 OS=Homo sapiens OX=9606 GN=MAN2A1 PE=1 SV=2Q9NP58ABCB6 ABCB6_HUMAN*ATP-binding cassette sub-family B member 6porphyrin-containing compound biosynthetic process,transport,cellular iron ion homeostasis,brain development,heme transport,skin development,transmembrane transport~ATP binding,heme transporter activity,heme-transporting ATPase activity,efflux transmembrane transporter activity,heme bindingLGolgi membrane,nucleoplasm,mitochondrion,mitochondrial envelope,mitochondrial outer membrane,endosome,endoplasmic reticulum,endoplasmic reticulum membrane,Golgi apparatus,cytosol,plasma membrane,endosome membrane,integral component of mitochondrial outer membrane,ATP-binding cassette (ABC) transporter complex,extracellular exosomel>sp|Q9NP58|ABCB6_HUMAN ATP-binding cassette sub-family B member 6 OS=Homo sapiens OX=9606 GN=ABCB6 PE=1 SV=1P51570GALK1 GALK1_HUMAN Galactokinasegalactose metabolic process,galactose catabolic process,galactitol metabolic process,carbohydrate phosphorylation,glycolytic process from galactose4galactokinase activity,ATP binding,galactose binding0cytoplasm,cytosol,membrane,extracellular exosomeO>sp|P51570|GALK1_HUMAN Galactokinase OS=Homo sapiens OX=9606 GN=GALK1 PE=1 SV=1Q13547HDAC1 HDAC1_HUMANHistone deacetylase 1negative regulation of transcription from RNA polymerase II promoter,chromatin organization,chromatin remodeling,methylation-dependent chromatin silencing,transcription, DNA-templated,protein deacetylation,blood coagulation,positive regulation of cell proliferation,epidermal cell differentiation,negative regulation of gene expression,positive regulation of receptor biosynthetic process,viral process,histone deacetylation,circadian regulation of gene expression,odontogenesis of dentin-containing tooth,embryonic digit morphogenesis,ATP-dependent chromatin remodeling,negative regulation of apoptotic process,negative regulation by host of viral transcription,negative regulation of transcription, DNA-templated,positive regulation of transcription, DNA-templated,positive regulation of transcription from RNA polymerase II promoter,negative regulation of androgen receptor signaling pathway,hair follicle placode formation,eyelid development in camera-type eye,fungiform papilla formation,histone H3 deacetylation,histone H4 deacetylation,negative regulation of canonical Wnt signaling pathway,regulation of signal transduction by p53 class mediator,beta-catenin-TCF complex assembly,negative regulation of myotube differentiationatranscription regulatory region sequence-specific DNA binding,core promoter binding,RNA polymerase II transcription factor binding,RNA polymerase II repressing transcription factor binding,RNA polymerase II transcription corepressor activity,transcription factor activity, sequence-specific DNA binding,histone deacetylase activity,protein binding,transcription factor binding,deacetylase activity,enzyme binding,NAD-dependent histone deacetylase activity (H3-K14 specific),protein deacetylase activity,activating transcription factor binding,histone deacetylase binding,transcription regulatory region DNA binding,protein N-terminus binding,NF-kappaB binding,repressing transcription factor binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II distal enhancer sequence-specific DNA binding,nucleosomal DNA bindinghistone deacetylase complex,chromatin,nuclear chromatin,nucleus,nucleoplasm,cytoplasm,cytosol,Sin3 complex,NuRD complex,protein complexW>sp|Q13547|HDAC1_HUMAN Histone deacetylase 1 OS=Homo sapiens OX=9606 GN=HDAC1 PE=1 SV=1P35268RPL22 RL22_HUMAN60S ribosomal protein L22nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,cytoplasmic translation,rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,viral transcription,alpha-beta T cell differentiationNRNA binding,structural constituent of ribosome,protein binding,heparin bindingnucleus,cytoplasm,cytosol,focal adhesion,cytosolic large ribosomal subunit,intracellular ribonucleoprotein complex,extracellular matrix,extracellular exosomeZ>sp|P35268|RL22_HUMAN 60S ribosomal protein L22 OS=Homo sapiens OX=9606 GN=RPL22 PE=1 SV=2Q7Z3U7MON2 MON2_HUMANProtein MON2 homolog-Golgi to endosome transport,protein transportT>sp|Q7Z3U7|MON2_HUMAN Protein MON2 homolog OS=Homo sapiens OX=9606 GN=MON2 PE=1 SV=3P61923COPZ1 COPZ1_HUMANCoatomer subunit zeta-1intracellular protein transport,ER to Golgi vesicle-mediated transport,retrograde vesicle-mediated transport, Golgi to ER,intra-Golgi vesicle-mediated transport,toxin transportYGolgi membrane,endoplasmic reticulum membrane,cytosol,COPI vesicle coat,transport vesicleY>sp|P61923|COPZ1_HUMAN Coatomer subunit zeta-1 OS=Homo sapiens OX=9606 GN=COPZ1 PE=1 SV=1O43684BUB3 BUB3_HUMANMitotic checkpoint protein BUB3emitotic sister chromatid segregation,sister chromatid cohesion,attachment of spindle microtubules to kinetochore,anaphase-promoting complex-dependent catabolic process,protein ubiquitination involved in ubiquitin-dependent protein catabolic process,proteasome-mediated ubiquitin-dependent protein catabolic process,cell division,meiotic cell cycle,negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition,regulation of chromosome segregation,spindle assembly checkpoint@kinetochore,condensed chromosome kinetochore,nucleoplasm,cytosol_>sp|O43684|BUB3_HUMAN Mitotic checkpoint protein BUB3 OS=Homo sapiens OX=9606 GN=BUB3 PE=1 SV=1Q9BQA1WDR77 MEP50_HUMANMethylosome protein 50jspliceosomal snRNP assembly,regulation of transcription from RNA polymerase II promoter,positive regulation of cell proliferation,peptidyl-arginine N-methylation,secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development,negative regulation of epithelial cell proliferation involved in prostate gland developmentprotein binding,methyl-CpG binding,protein-arginine N-methyltransferase activity,ligand-dependent nuclear receptor transcription coactivator activityAnucleus,nucleoplasm,cytoplasm,Golgi apparatus,cytosol,methylosomeX>sp|Q9BQA1|MEP50_HUMAN Methylosome protein 50 OS=Homo sapiens OX=9606 GN=WDR77 PE=1 SV=1P13591NCAM1 NCAM1_HUMANNeural cell adhesion molecule 1MAPK cascade,cell adhesion,axon guidance,positive regulation of GTPase activity,viral entry into host cell,interferon-gamma-mediated signaling pathwayFvirus receptor activity,Ras guanyl-nucleotide exchange factor activityGolgi membrane,cytosol,plasma membrane,external side of plasma membrane,cell surface,membrane,integral component of membrane,anchored component of membrane,extracellular exosomea>sp|P13591|NCAM1_HUMAN Neural cell adhesion molecule 1 OS=Homo sapiens OX=9606 GN=NCAM1 PE=1 SV=3P20936RASA1 RASA1_HUMANRas GTPase-activating protein 1MAPK cascade,mitotic cytokinesis,vasculogenesis,negative regulation of cell-matrix adhesion,negative regulation of cell adhesion,signal transduction,regulation of cell shape,embryo development,regulation of actin filament polymerization,intracellular signal transduction,negative regulation of neuron apoptotic process,positive regulation of GTPase activity,negative regulation of Ras protein signal transduction,ephrin receptor signaling pathway,blood vessel morphogenesis,regulation of RNA metabolic processglycoprotein binding,GTPase activator activity,receptor binding,protein binding,potassium channel inhibitor activity,GTPas< e binding[ruffle,cytoplasm,cytosol,intrinsic component of the cytoplasmic side of the plasma membranea>sp|P20936|RASA1_HUMAN Ras GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=RASA1 PE=1 SV=1O15371EIF3D EIF3D_HUMAN4Eukaryotic translation initiation factor 3 subunit Dformation of cytoplasmic translation initiation complex,cap-dependent translational initiation,translational initiation,positive regulation of translation,IRES-dependent viral translational initiation,viral translational termination-reinitiation,positive regulation of mRNA bindingSRNA binding,protein binding,mRNA cap binding,translation initiation factor activity}cytosol,eukaryotic translation initiation factor 3 complex,membrane,eukaryotic translation initiation factor 3 complex, eIF3mv>sp|O15371|EIF3D_HUMAN Eukaryotic translation initiation factor 3 subunit D OS=Homo sapiens OX=9606 GN=EIF3D PE=1 SV=1P62913RPL11 RL11_HUMAN60S ribosomal protein L11>ribosomal large subunit assembly,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,rRNA processing,translation,translational initiation,protein targeting,SRP-dependent cotranslational protein targeting to membrane,viral transcription,protein localization to nucleus,ribosomal large subunit biogenesisKRNA binding,structural constituent of ribosome,protein binding,rRNA binding}nucleoplasm,nucleolus,cytoplasm,cytosol,membrane,cytosolic large ribosomal subunit,extracellular matrix,extracellular exosomeZ>sp|P62913|RL11_HUMAN 60S ribosomal protein L11 OS=Homo sapiens OX=9606 GN=RPL11 PE=1 SV=2Q8N1G4LRRC47 LRC47_HUMAN)Leucine-rich repeat-containing protein 47>RNA binding,phenylalanine-tRNA ligase activity,protein bindingl>sp|Q8N1G4|LRC47_HUMAN Leucine-rich repeat-containing protein 47 OS=Homo sapiens OX=9606 GN=LRRC47 PE=1 SV=1O00534VWA5A VMA5A_HUMAN4von Willebrand factor A domain-containing protein 5Av>sp|O00534|VMA5A_HUMAN von Willebrand factor A domain-containing protein 5A OS=Homo sapiens OX=9606 GN=VWA5A PE=1 SV=2P46778RPL21 RL21_HUMAN60S ribosomal protein L212cytosol,membrane,cytosolic large ribosomal subunitZ>sp|P46778|RL21_HUMAN 60S ribosomal protein L21 OS=Homo sapiens OX=9606 GN=RPL21 PE=1 SV=2P19525EIF2AK2 E2AK2_HUMAN@Interferon-induced, double-stranded RNA-activated protein kinaseactivation of MAPKK activity,positive regulation of cytokine production,transcription, DNA-templated,translation,protein phosphorylation,negative regulation of cell proliferation,response to virus,response to toxic substance,regulation of translational initiation by eIF2 alpha phosphorylation,negative regulation of translation,peptidyl-tyrosine phosphorylation,evasion or tolerance by virus of host immune response,endoplasmic reticulum unfolded protein response,positive regulation of chemokine production,positive regulation of stress-activated MAPK cascade,negative regulation of osteoblast proliferation,cellular response to amino acid starvation,response to interferon-alpha,negative regulation of apoptotic process,negative regulation of viral genome replication,innate immune response,protein autophosphorylation,positive regulation of NF-kappaB transcription factor activity,defense response to virus,regulation of NLRP3 inflammasome complex assembly,positive regulation of NIK/NF-kappaB signaling,regulation of hematopoietic progenitor cell differentiation,regulation of hematopoietic stem cell proliferation,regulation of hematopoietic stem cell differentiation"RNA binding,double-stranded RNA binding,protein kinase activity,protein serine/threonine kinase activity,eukaryotic translation initiation factor 2alpha kinase activity,non-membrane spanning protein tyrosine kinase activity,protein binding,ATP binding,protein phosphatase regulator activityKnucleus,cytoplasm,cytosol,ribosome,membrane,perinuclear region of cytoplasm>sp|P19525|E2AK2_HUMAN Interferon-induced, double-stranded RNA-activated protein kinase OS=Homo sapiens OX=9606 GN=EIF2AK2 PE=1 SV=2 P02042;P68871HBD;HBBHBD_HUMAN;HBB_HUMAN0Hemoglobin subunit delta;Hemoglobin subunit betablood coagulation,oxygen transport;receptor-mediated endocytosis,blood coagulation,regulation of blood pressure,positive regulation of cell death,oxygen transport,bicarbonate transport,nitric oxide transport,response to hydrogen peroxide,hydrogen peroxide catabolic process,neutrophil degranulation,positive regulation of nitric oxide biosynthetic process,regulation of blood vessel size,protein heterooligomerization,renal absorption,platelet aggregation,cellular oxidant detoxificationoxygen transporter activity,iron ion binding,protein binding,oxygen binding,heme binding;oxygen transporter activity,iron ion binding,protein binding,oxygen binding,heme binding,hemoglobin binding,peroxidase activity,haptoglobin bindingcytosol,hemoglobin complex,blood microparticle;extracellular region,cytosol,hemoglobin complex,haptoglobin-hemoglobin complex,extracellular exosome,endocytic vesicle lumen,blood microparticle,tertiary granule lumen,ficolin-1-rich granule lumen>sp|P02042|HBD_HUMAN Hemoglobin subunit delta OS=Homo sapiens OX=9606 GN=HBD PE=1 SV=2;>sp|P68871|HBB_HUMAN Hemoglobin subunit beta OS=Homo sapiens OX=9606 GN=HBB PE=1 SV=2Q15012LAPTM4A LAP4A_HUMAN-Lysosomal-associated transmembrane protein 4A transport.Golgi apparatus,integral component of membraneq>sp|Q15012|LAP4A_HUMAN Lysosomal-associated transmembrane protein 4A OS=Homo sapiens OX=9606 GN=LAPTM4A PE=1 SV=1P15153RAC2 RAC2_HUMAN*Ras-related C3 botulinum toxin substrate 2 chemotaxis,actin filament organization,signal transduction,G-protein coupled receptor signaling pathway,small GTPase mediated signal transduction,positive regulation of cell proliferation,regulation of hydrogen peroxide metabolic process,positive regulation of lamellipodium assembly,regulation of cell-substrate adhesion,cell projection assembly,platelet activation,regulation of T cell proliferation,regulation of mast cell degranulation,bone resorption,regulation of protein kinase activity,regulation of small GTPase mediated signal transduction,regulation of respiratory burst,regulation of mast cell chemotaxis,lymphocyte aggregation,positive regulation of neutrophil chemotaxis,regulation of neutrophil migration,positive regulation of protein targeting to mitochondrion=GTPase activity,GTP binding,protein kinase regulator activitynuclear envelope,cytosol,plasma membrane,focal adhesion,lamellipodium,phagocytic vesicle membrane,extracellular exosome,actin filamentj>sp|P15153|RAC2_HUMAN Ras-related C3 botulinum toxin substrate 2 OS=Homo sapiens OX=9606 GN=RAC2 PE=1 SV=1O95352ATG7 ATG7_HUMAN.Ubiquitin-like modifier-activating enzyme ATG7mitophagy,cellular protein modification process,protein lipidation,autophagy,aging,cellular response to starvation,response to glucose,positive regulation of autophagy,protein transport,macroautophagy,protein ubiquitination,positive regulation of protein modification process,suppression by virus of host autophagy,positive regulation of apoptotic process,neutrophil degranulation,positive regulation of protein catabolic process,defense response to virus,membrane fusion,cellular response to morphine,cellular response to hyperoxia,negative regulation of mitochondrial DNA replication,response to fluoride,negative regulation of oxidative stress-induced neuron deathubiquitin activating enzyme activity,protein binding,transcription factor binding,Atg12 activating enzyme activity,protein homodimerization activitypre-autophagosomal structure,extracellular region,cytoplasm,cytosol,axoneme,axon,secretory granule lumen,ficolin-1-rich granule lumenn>sp|O95352|ATG7_HUMAN Ubiquitin-like modifier-activating enzyme ATG7 OS=Homo sapiens OX=9606 GN=ATG7 PE=1 SV=1P02100;P69891;P69892HBE1;HBG1;HBG2HBE_HUMAN;HBG1_HUMAN;HBG2_HUMANPHemoglobin subunit epsilon;Hemoglobin subunit gamma-1;Hemoglobin subunit gamma-2blood coagulation,response to organic cyclic compound,oxygen transport,protein heterooligomerization;blood coagulation,oxygen transport;blood coagulation,oxygen transportoxygen transporter activity,iron ion bin< ding,protein binding,oxygen binding,heme binding,hemoglobin alpha binding;oxygen transporter activity,iron ion binding,oxygen binding,heme binding;oxygen transporter activity,iron ion binding,oxygen binding,heme bindingxcytosol,hemoglobin complex,blood microparticle;cytosol,hemoglobin complex;cytosol,hemoglobin complex,blood microparticle>sp|P02100|HBE_HUMAN Hemoglobin subunit epsilon OS=Homo sapiens OX=9606 GN=HBE1 PE=1 SV=2;>sp|P69891|HBG1_HUMAN Hemoglobin subunit gamma-1 OS=Homo sapiens OX=9606 GN=HBG1 PE=1 SV=2;>sp|P69892|HBG2_HUMAN Hemoglobin subunit gamma-2 OS=Homo sapiens OX=9606 GN=HBG2 PE=1 SV=2Q9BQE3TUBA1C TBA1C_HUMANTubulin alpha-1C chainpcytoskeleton organization,microtubule-based process,cytoskeleton-dependent intracellular transport,cell divisionoGTPase activity,structural molecule activity,structural constituent of cytoskeleton,protein binding,GTP binding>nucleus,cytoplasm,microtubule,microtubule cytoskeleton,vesicleY>sp|Q9BQE3|TBA1C_HUMAN Tubulin alpha-1C chain OS=Homo sapiens OX=9606 GN=TUBA1C PE=1 SV=1P07437TUBB TBB5_HUMANTubulin beta chain&G2/M transition of mitotic cell cycle,movement of cell or subcellular component,microtubule-based process,cellular process,cytoskeleton-dependent intracellular transport,natural killer cell mediated cytotoxicity,neutrophil degranulation,spindle assembly,cell division,ciliary basal body dockingGTPase activity,structural molecule activity,structural constituent of cytoskeleton,protein binding,GTP binding,protein domain specific binding,ubiquitin protein ligase binding,protein complex binding,GTPase activating protein binding,MHC class I protein bindingextracellular region,nucleus,nuclear envelope lumen,cytoskeleton,microtubule,microtubule cytoskeleton,extracellular matrix,azurophil granule lumen,cytoplasmic ribonucleoprotein granule,protein complex,cell body,extracellular exosomeR>sp|P07437|TBB5_HUMAN Tubulin beta chain OS=Homo sapiens OX=9606 GN=TUBB PE=1 SV=2Q7L523RRAGA RRAGA_HUMAN!Ras-related GTP-binding protein Aapoptotic process,cell cycle arrest,cell death,negative regulation of autophagy,macroautophagy,protein ubiquitination,modulation by virus of host morphology or physiology,positive regulation of TOR signaling,cellular response to amino acid starvation,cellular protein localization,positive regulation of cytolysis,cellular response to amino acid stimulus,positive regulation of TORC1 signalingGTPase activity,protein binding,GTP binding,ubiquitin protein ligase binding,protein homodimerization activity,protein heterodimerization activity,phosphoprotein bindingBnucleus,cytoplasm,lysosome,lysosomal membrane,cytosol,Iml1 complexc>sp|Q7L523|RRAGA_HUMAN Ras-related GTP-binding protein A OS=Homo sapiens OX=9606 GN=RRAGA PE=1 SV=1P60981DSTN DEST_HUMANDestrinactin polymerization or depolymerization,actin filament depolymerization,actin filament fragmentation,positive regulation of actin filament depolymerization,actin filament severing&protein binding,actin filament bindingDactin cytoskeleton,cortical actin cytoskeleton,extracellular exosomeG>sp|P60981|DEST_HUMAN Destrin OS=Homo sapiens OX=9606 GN=DSTN PE=1 SV=3Q2M389WASHC4 WASC4_HUMANWASH complex subunit 4;endosome organization,protein transport,endosomal transport3endosome,early endosome,WASH complex,BLOC-1 complexY>sp|Q2M389|WASC4_HUMAN WASH complex subunit 4 OS=Homo sapiens OX=9606 GN=WASHC4 PE=1 SV=2Q9UBQ6EXTL2 EXTL2_HUMANExostosin-like 2glycosaminoglycan biosynthetic process,N-acetylglucosamine metabolic process,heparan sulfate proteoglycan biosynthetic process,UDP-N-acetylgalactosamine metabolic processglucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity,alpha-1,4-N-acetylgalactosaminyltransferase activity,metal ion bindingiendoplasmic reticulum,endoplasmic reticulum membrane,integral component of membrane,extracellular exosomeR>sp|Q9UBQ6|EXTL2_HUMAN Exostosin-like 2 OS=Homo sapiens OX=9606 GN=EXTL2 PE=1 SV=1 P68400;Q8NEV1CSNK2A1;CSNK2A3CSK21_HUMAN;CSK23_HUMAN?Casein kinase II subunit alpha;Casein kinase II subunit alpha 3transcription, DNA-templated,regulation of transcription, DNA-templated,protein folding,protein phosphorylation,phosphatidylcholine biosynthetic process,apoptotic process,signal transduction,positive regulation of cell proliferation,Wnt signaling pathway,positive regulation of Wnt signaling pathway,positive regulation of cell growth,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process,positive regulation of protein catabolic process,rhythmic process,chaperone-mediated protein folding,mitotic spindle checkpoint,regulation of signal transduction by p53 class mediator;protein phosphorylation,positive regulation of cell proliferation,positive regulation of cell growth,positive regulation of protein catabolic processprotein serine/threonine kinase activity,protein binding,ATP binding,kinase activity,protein N-terminus binding,Hsp90 protein binding;protein serine/threonine kinase activity,protein binding,ATP bindingenucleus,nucleoplasm,cytosol,plasma membrane,Sin3 complex,NuRD complex,PcG protein complex;nucleoplasm1;2>sp|P68400|CSK21_HUMAN Casein kinase II subunit alpha OS=Homo sapiens OX=9606 GN=CSNK2A1 PE=1 SV=1;>sp|Q8NEV1|CSK23_HUMAN Casein kinase II subunit alpha 3 OS=Homo sapiens OX=9606 GN=CSNK2A3 PE=1 SV=2O00754MAN2B1 MA2B1_HUMANLysosomal alpha-mannosidasemannose metabolic process,cellular protein modification process,protein deglycosylation,oligosaccharide catabolic process,neutrophil degranulation@alpha-mannosidase activity,zinc ion binding,carbohydrate bindingfextracellular region,extracellular space,azurophil granule lumen,lysosomal lumen,extracellular exosome^>sp|O00754|MA2B1_HUMAN Lysosomal alpha-mannosidase OS=Homo sapiens OX=9606 GN=MAN2B1 PE=1 SV=3Q9NUM4TMEM106B T106B_HUMANTransmembrane protein 106Blysosome organization,lysosomal transport,lysosome localization,dendrite morphogenesis,positive regulation of dendrite developmentplysosome,lysosomal membrane,endosome,integral component of membrane,late endosome membrane,extracellular exosome_>sp|Q9NUM4|T106B_HUMAN Transmembrane protein 106B OS=Homo sapiens OX=9606 GN=TMEM106B PE=1 SV=2P31948STIP1 STIP1_HUMANStress-induced-phosphoprotein 1response to stress^RNA binding,protein binding,protein C-terminus binding,Hsp70 protein binding,chaperone binding5nucleus,Golgi apparatus,myelin sheath,protein complexa>sp|P31948|STIP1_HUMAN Stress-induced-phosphoprotein 1 OS=Homo sapiens OX=9606 GN=STIP1 PE=1 SV=1P04844RPN2 RPN2_HUMANHDolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2cellular protein modification process,protein N-linked glycosylation,aging,protein N-linked glycosylation via asparagine,response to drugdprotein binding,ribosome binding,dolichyl-diphosphooligosaccharide-protein glycotransferase activityautophagosome membrane,endoplasmic reticulum membrane,rough endoplasmic reticulum,oligosaccharyltransferase complex,membrane,integral component of membrane>sp|P04844|RPN2_HUMAN Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 OS=Homo sapiens OX=9606 GN=RPN2 PE=1 SV=3P60866RPS20 RS20_HUMAN40S ribosomal protein S20inucleoplasm,cytosol,membrane,cytosolic small ribosomal subunit,extracellular matrix,extracellular exosomeZ>sp|P60866|RS20_HUMAN 40S ribosomal protein S20 OS=Homo sapiens OX=9606 GN=RPS20 PE=1 SV=1O95197RTN3 RTN3_HUMAN Reticulon-3apoptotic process,viral process,vesicle-mediated transport,endoplasmic reticulum tubular network organization,endoplasmic reticulum tubular network assemblyGolgi membrane,extracellular space,endoplasmic reticulum,endoplasmic reticulum membrane,plasma membrane,integral component of membrane,extracellular exosomeK>sp|O95197|RTN3_HUMAN Reticulon-3 OS=Homo sapiens OX=9606 GN=RTN3 PE=1 SV=2P09543CNP CN37_HUMAN,2',3'-cyclic-nucleotide 3'-phosphodiesteraseUmicrotubule cytoskeleton organization,chemical synaptic transmission,axonogenesis,aging,adult locomotory behavior,cyclic nucleot< ide catabolic process,response to toxic substance,substantia nigra development,forebrain development,response to lipopolysaccharide,regulation of mitochondrial membrane permeability,oligodendrocyte differentiation[RNA binding,2',3'-cyclic-nucleotide 3'-phosphodiesterase activity,cyclic nucleotide bindingextracellular space,cytoplasm,mitochondrial outer membrane,mitochondrial inner membrane,plasma membrane,microvillus,membrane,pseudopodium,myelin sheath abaxonal region,myelin sheath adaxonal region,melanosome,perinuclear region of cytoplasm,extracellular exosomek>sp|P09543|CN37_HUMAN 2',3'-cyclic-nucleotide 3'-phosphodiesterase OS=Homo sapiens OX=9606 GN=CNP PE=1 SV=2P25116F2R PAR1_HUMANProteinase-activated receptor 1 activation of MAPKK activity,connective tissue replacement involved in inflammatory response wound healing,negative regulation of glomerular filtration,activation of cysteine-type endopeptidase activity involved in apoptotic process,inflammatory response,G-protein coupled receptor signaling pathway,phospholipase C-activating G-protein coupled receptor signaling pathway,positive regulation of cytosolic calcium ion concentration,protein kinase C-activating G-protein coupled receptor signaling pathway,tyrosine phosphorylation of STAT protein,STAT protein import into nucleus,establishment of synaptic specificity at neuromuscular junction,blood coagulation,positive regulation of cell proliferation,negative regulation of cell proliferation,response to wounding,anatomical structure morphogenesis,positive regulation of phosphatidylinositol 3-kinase signaling,platelet activation,regulation of blood coagulation,positive regulation of blood coagulation,positive regulation of cell migration,response to lipopolysaccharide,regulation of interleukin-1 beta production,positive regulation of collagen biosynthetic process,positive regulation of Rho protein signal transduction,positive regulation of I-kappaB kinase/NF-kappaB signaling,positive regulation of cysteine-type endopeptidase activity involved in apoptotic process,positive regulation of MAPK cascade,negative regulation of neuron apoptotic process,positive regulation of transcription, DNA-templated,positive regulation of vasoconstriction,positive regulation of smooth muscle contraction,positive regulation of JAK-STAT cascade,homeostasis of number of cells within a tissue,release of sequestered calcium ion into cytosol,positive regulation of release of sequestered calcium ion into cytosol,positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway,positive regulation of calcium ion transport,regulation of sensory perception of pain,platelet dense granule organization,positive regulation of ERK1 and ERK2 cascade,thrombin-activated receptor signaling pathway,trans-synaptic signaling by endocannabinoid, modulating synaptic transmission,negative regulation of renin secretion into blood stream,positive regulation of interleukin-8 secretion,positive regulation of interleukin-6 secretionG-protein alpha-subunit binding,G-protein coupled receptor activity,receptor binding,protein binding,thrombin-activated receptor activity,G-protein beta-subunit bindingextracellular region,early endosome,late endosome,Golgi apparatus,plasma membrane,integral component of plasma membrane,caveola,cell surface,platelet dense tubular network,neuromuscular junction,postsynaptic membrane^>sp|P25116|PAR1_HUMAN Proteinase-activated receptor 1 OS=Homo sapiens OX=9606 GN=F2R PE=1 SV=2P53990IST1 IST1_HUMAN IST1 homologTcytokinesis,protein localization,abscission,protein transport,viral release from host cell,multivesicular body assembly,neutrophil degranulation,establishment of protein localization,positive regulation of proteolysis,viral capsid secondary envelopment,positive regulation of collateral sprouting,cell division,ESCRT III complex disassemblykprotein binding,protein domain specific binding,protein complex binding,cadherin binding,MIT domain bindingextracellular region,nuclear envelope,endoplasmic reticulum-Golgi intermediate compartment,centrosome,cytosol,midbody,azurophil granule lumen,intracellular membrane-bounded organelle,extracellular exosome,Flemming bodyL>sp|P53990|IST1_HUMAN IST1 homolog OS=Homo sapiens OX=9606 GN=IST1 PE=1 SV=1O60493SNX3 SNX3_HUMANSorting nexin-3response to bacterium,membrane invagination,positive regulation of neuron projection development,protein transport,Wnt signaling pathway,protein deubiquitination,protein to membrane docking,regulation of Wnt signaling pathway,negative regulation of protein catabolic process,negative regulation of viral entry into host cell,negative regulation of phagocytosis,negative regulation of protein transport,intralumenal vesicle formation,negative regulation of early endosome to late endosome transportprotein binding,phosphatidylinositol-5-phosphate binding,protein phosphatase binding,phosphatidylinositol-3-phosphate binding,phosphatidylinositol-4-phosphate binding,phosphatidylinositol-3,5-bisphosphate bindingcytoplasm,early endosome,cytosol,endosome membrane,extrinsic component of membrane,clathrin-coated vesicle,early endosome membrane,early phagosome,extracellular exosome,retromer complexO>sp|O60493|SNX3_HUMAN Sorting nexin-3 OS=Homo sapiens OX=9606 GN=SNX3 PE=1 SV=3Q53GQ0HSD17B12 DHB12_HUMAN'Very-long-chain 3-oxoacyl-CoA reductasefatty acid biosynthetic process,estrogen biosynthetic process,positive regulation of cell-substrate adhesion,extracellular matrix organization,long-chain fatty-acyl-CoA biosynthetic process,oxidation-reduction process*fibronectin binding,estradiol 17-beta-dehydrogenase activity,protein binding,collagen binding,heparin binding,long-chain-3-hydroxyacyl-CoA dehydrogenase activity,3-oxo-arachidoyl-CoA reductase activity,3-oxo-behenoyl-CoA reductase activity,3-oxo-lignoceroyl-CoA reductase activity,Requires Ontology`proteinaceous extracellular matrix,endoplasmic reticulum membrane,integral component of membranel>sp|Q53GQ0|DHB12_HUMAN Very-long-chain 3-oxoacyl-CoA reductase OS=Homo sapiens OX=9606 GN=HSD17B12 PE=1 SV=2P30838ALDH3A1 AL3A1_HUMAN/Aldehyde dehydrogenase, dimeric NADP-preferringresponse to hypoxia,cellular aldehyde metabolic process,xenobiotic metabolic process,aging,response to nutrient,positive regulation of cell proliferation,response to drug,response to glucocorticoid,response to cAMP,oxidation-reduction process3-chloroallyl aldehyde dehydrogenase activity,aldehyde dehydrogenase (NAD) activity,aldehyde dehydrogenase [NAD(P)+] activity,protein binding,alcohol dehydrogenase (NADP+) activity,benzaldehyde dehydrogenase (NAD+) activity`extracellular space,endoplasmic reticulum,cytosol,plasma membrane,integral component of membranes>sp|P30838|AL3A1_HUMAN Aldehyde dehydrogenase, dimeric NADP-preferring OS=Homo sapiens OX=9606 GN=ALDH3A1 PE=1 SV=3Q9NS93TM7SF3 TM7S3_HUMAN$Transmembrane 7 superfamily member 3g>sp|Q9NS93|TM7S3_HUMAN Transmembrane 7 superfamily member 3 OS=Homo sapiens OX=9606 GN=TM7SF3 PE=2 SV=1Q15404RSU1 RSU1_HUMANRas suppressor protein 1signal transduction,positive regulation of cell-substrate adhesion,positive regulation of GTPase activity,regulation of cell-substrate adhesion,cytosol,focal adhesion,extracellular exosomeX>sp|Q15404|RSU1_HUMAN Ras suppressor protein 1 OS=Homo sapiens OX=9606 GN=RSU1 PE=1 SV=3P62070RRAS2 RRAS2_HUMANRas-related protein R-Ras2{osteoblast differentiation,Ras protein signal transduction,positive regulation of cell migration,regulation of neuron death+GTPase activity,protein binding,GTP bindingSendoplasmic reticulum,plasma membrane,focal adhesion,membrane,extracellular exosome\>sp|P62070|RRAS2_HUMAN Ras-related protein R-Ras2 OS=Homo sapiens OX=9606 GN=RRAS2 PE=1 SV=1Q9UKM9RALY RALY_HUMANRNA-binding protein RalymRNA splicing, via spliceosome,transcription, DNA-templated,regulation of transcription, DNA-templated,regulation of nucleic acid-templated transcription,regulation of cholesterol homeostasisNnucleotide binding,transcription cofactor activity,RNA binding,prot< ein binding$nucleus,catalytic step 2 spliceosomeX>sp|Q9UKM9|RALY_HUMAN RNA-binding protein Raly OS=Homo sapiens OX=9606 GN=RALY PE=1 SV=1P35241RDX RADI_HUMANRadixin:regulation of cell shape,regulation of cell size,positive regulation of gene expression,protein kinase A signaling,microvillus assembly,positive regulation of cell migration,regulation of actin filament bundle assembly,regulation of Rap protein signal transduction,negative regulation of homotypic cell-cell adhesion,negative regulation of GTPase activity,cellular response to platelet-derived growth factor stimulus,regulation of GTPase activity,apical protein localization,establishment of protein localization,negative regulation of cell size,barbed-end actin filament capping,establishment of endothelial barrier,establishment of protein localization to plasma membrane,cellular response to thyroid hormone stimulus,regulation of ruffle assembly,positive regulation of G1/S transition of mitotic cell cycle,regulation of organelle assembly,positive regulation of protein localization to early endosome,positive regulation of cellular protein catabolic process,negative regulation of adherens junction organization,positive regulation of early endosome to late endosome transportRNA binding,actin binding,protein binding,protein domain specific binding,protein homodimerization activity,cadherin binding,protein kinase A binding,ATPase binding7ruffle,extracellular space,plasma membrane,microvillus,cell-cell adherens junction,focal adhesion,apical plasma membrane,extrinsic component of membrane,lamellipodium,filopodium,T-tubule,midbody,cortical actin cytoskeleton,cleavage furrow,stereocilium,myelin sheath,cell tip,extracellular exosome,cell peripheryF>sp|P35241|RADI_HUMAN Radixin OS=Homo sapiens OX=9606 GN=RDX PE=1 SV=1P49754VPS41 VPS41_HUMAN6Vacuolar protein sorting-associated protein 41 homologprotein targeting to vacuole,autophagy,endosome to lysosome transport,endosomal vesicle fusion,regulation of SNARE complex assembly,vacuole fusion, non-autophagic,regulated exocytosis,late endosome to lysosome transportvprotein binding,microtubule binding,zinc ion binding,identical protein binding,protein self-association,GTPase bindinglysosomal membrane,early endosome,Golgi-associated vesicle,endosome membrane,microtubule cytoskeleton,clathrin-coated vesicle,HOPS complex,late endosome membrane,CORVET complex,AP-3 adaptor complex,clathrin complexx>sp|P49754|VPS41_HUMAN Vacuolar protein sorting-associated protein 41 homolog OS=Homo sapiens OX=9606 GN=VPS41 PE=1 SV=3P51572BCAP31 BAP31_HUMAN%B-cell receptor-associated protein 31antigen processing and presentation of peptide antigen via MHC class I,intracellular protein transport,ER to Golgi vesicle-mediated transport,positive regulation of cytosolic calcium ion concentration,spermatogenesis,negative regulation of endoplasmic reticulum calcium ion concentration,calcium-mediated signaling using intracellular calcium source,positive regulation of cysteine-type endopeptidase activity involved in apoptotic process,positive regulation of mitochondrial calcium ion concentration,protein localization to endoplasmic reticulum exit site,execution phase of apoptosis,positive regulation of ER-associated ubiquitin-dependent protein catabolic process,positive regulation of retrograde protein transport, ER to cytosol,positive regulation of intrinsic apoptotic signaling pathwayCprotein binding,protein complex binding,MHC class I protein bindingvmitochondrion,endoplasmic reticulum,endoplasmic reticulum membrane,lipid particle,cytosol,integral component of plasma membrane,membrane,clathrin-coated vesicle,Golgi cisterna membrane,endoplasmic reticulum-Golgi intermediate compartment membrane,integral component of lumenal side of endoplasmic reticulum membrane,perinuclear endoplasmic reticulum,Sec61 translocon complexh>sp|P51572|BAP31_HUMAN B-cell receptor-associated protein 31 OS=Homo sapiens OX=9606 GN=BCAP31 PE=1 SV=3O75962TRIO TRIO_HUMAN Triple functional domain proteinprotein phosphorylation,transmembrane receptor protein tyrosine phosphatase signaling pathway,regulation of Rho protein signal transduction,positive regulation of apoptotic process,positive regulation of GTPase activity,regulation of small GTPase mediated signal transductionprotein serine/threonine kinase activity,guanyl-nucleotide exchange factor activity,Rho guanyl-nucleotide exchange factor activity,protein binding,ATP binding,enzyme binding`>sp|O75962|TRIO_HUMAN Triple functional domain protein OS=Homo sapiens OX=9606 GN=TRIO PE=1 SV=2Q9ULC3RAB23 RAB23_HUMANRas-related protein Rab-23autophagosome assembly,cellular defense response,small GTPase mediated signal transduction,protein transport,negative regulation of transcription factor import into nucleus,cilium morphogenesis,craniofacial suture morphogenesiscytoplasm,autophagosome,centrosome,cytosol,plasma membrane,endosome membrane,cell junction,phagocytic vesicle membrane,phagocytic vesicle,extracellular exosome\>sp|Q9ULC3|RAB23_HUMAN Ras-related protein Rab-23 OS=Homo sapiens OX=9606 GN=RAB23 PE=1 SV=1P52895AKR1C2 AK1C2_HUMAN&Aldo-keto reductase family 1 member C2prostaglandin metabolic process,G-protein coupled receptor signaling pathway,digestion,steroid metabolic process,positive regulation of cell proliferation,epithelial cell differentiation,progesterone metabolic process,daunorubicin metabolic process,doxorubicin metabolic process,positive regulation of protein kinase B signaling,oxidation-reduction process,cellular response to jasmonic acid stimulus,cellular response to prostaglandin D stimulus*alditol:NADP+ 1-oxidoreductase activity,oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor,phenanthrene 9,10-monooxygenase activity,carboxylic acid binding,bile acid binding,ketosteroid monooxygenase activity,trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity cytoplasmi>sp|P52895|AK1C2_HUMAN Aldo-keto reductase family 1 member C2 OS=Homo sapiens OX=9606 GN=AKR1C2 PE=1 SV=3Q04756HGFAC HGFA_HUMAN"Hepatocyte growth factor activatorAserine-type endopeptidase activity,serine-type peptidase activity0extracellular region,extracellular space,cytosolc>sp|Q04756|HGFA_HUMAN Hepatocyte growth factor activator OS=Homo sapiens OX=9606 GN=HGFAC PE=1 SV=1P31689DNAJA1 DNJA1_HUMAN!DnaJ homolog subfamily A member 1protein folding,response to unfolded protein,spermatogenesis,response to heat,flagellated sperm motility,androgen receptor signaling pathway,negative regulation of protein ubiquitination,positive regulation of ATPase activity,DNA damage response, detection of DNA damage,positive regulation of apoptotic process,negative regulation of apoptotic process,negative regulation of JUN kinase activity,regulation of protein transport,protein localization to mitochondrion,toxin transport,negative regulation of establishment of protein localization to mitochondrion,negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway8G-protein coupled receptor binding,ATPase activator activity,protein binding,ATP binding,Hsp70 protein binding,Tat protein binding,ubiquitin protein ligase binding,metal ion binding,low-density lipoprotein particle receptor binding,unfolded protein binding,chaperone binding,C3HC4-type RING finger domain bindingnucleus,mitochondrion,cytosol,microtubule cytoskeleton,membrane,perinuclear region of cytoplasm,extracellular exosome,cytoplasmic side of endoplasmic reticulum membrane,ubiquitin ligase complexd>sp|P31689|DNJA1_HUMAN DnaJ homolog subfamily A member 1 OS=Homo sapiens OX=9606 GN=DNAJA1 PE=1 SV=2O00151PDLIM1 PDLI1_HUMANPDZ and LIM domain protein 1nresponse to hypoxia,regulation of transcription, DNA-templated,response to oxidative stress,cell-cell adhesionctranscription coactivator activity,zinc ion binding,cadherin binding involved in cell-cell adhesion^transcription factor complex,cytoplasm,cytoskeleton,cell-cell adherens junction,focal adhesion_>sp|O00151|PDLI1_HUMAN PDZ and LIM domain protein 1 OS=Homo sapiens OX=9606 GN=PDLIM1 PE=1 SV=4< Q96QA5GSDMA GSDMA_HUMAN Gasdermin-Aapoptotic process7cytosol,plasma membrane,perinuclear region of cytoplasmM>sp|Q96QA5|GSDMA_HUMAN Gasdermin-A OS=Homo sapiens OX=9606 GN=GSDMA PE=1 SV=4Q8N163CCAR2 CCAR2_HUMAN,Cell cycle and apoptosis regulator protein 2Ttranscription, DNA-templated,mRNA processing,cellular response to DNA damage stimulus,cell cycle,RNA splicing,response to UV,Wnt signaling pathway,negative regulation of cell growth,regulation of protein stability,negative regulation of proteasomal ubiquitin-dependent protein catabolic process,regulation of DNA-templated transcription, elongation,regulation of circadian rhythm,positive regulation of apoptotic process,negative regulation of catalytic activity,mitochondrial fragmentation involved in apoptotic process,negative regulation of transcription, DNA-templated,rhythmic process,positive regulation of canonical Wnt signaling pathway,regulation of protein deacetylation,regulation of cellular response to heat,negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage,positive regulation of DNA damage checkpointcRNA polymerase II core binding,RNA binding,enzyme inhibitor activity,protein binding,enzyme bindinggnuclear chromatin,nucleus,nucleoplasm,cytoplasm,mitochondrial matrix,DBIRD complex,spliceosomal complexn>sp|Q8N163|CCAR2_HUMAN Cell cycle and apoptosis regulator protein 2 OS=Homo sapiens OX=9606 GN=CCAR2 PE=1 SV=2Q9UBW8COPS7A CSN7A_HUMAN#COP9 signalosome complex subunit 7ayprotein deneddylation,nucleotide-excision repair, DNA damage recognition,transcription-coupled nucleotide-excision repairf>sp|Q9UBW8|CSN7A_HUMAN COP9 signalosome complex subunit 7a OS=Homo sapiens OX=9606 GN=COPS7A PE=1 SV=1O14763 TNFRSF10B TR10B_HUMAN5Tumor necrosis factor receptor superfamily member 10Bapoptotic process,activation of cysteine-type endopeptidase activity involved in apoptotic process,inflammatory response,immune response,cell surface receptor signaling pathway,activation of NF-kappaB-inducing kinase activity,multicellular organism development,extrinsic apoptotic signaling pathway via death domain receptors,response to lipopolysaccharide,tumor necrosis factor-mediated signaling pathway,response to endoplasmic reticulum stress,regulation of cell proliferation,regulation of apoptotic process,positive regulation of I-kappaB kinase/NF-kappaB signaling,leukocyte migration,intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress,cellular response to mechanical stimulus,activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway,regulation of extrinsic apoptotic signaling pathway via death domain receptors,negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsareceptor activity,tumor necrosis factor-activated receptor activity,protein binding,TRAIL bindingointracellular,plasma membrane,integral component of plasma membrane,cell surface,integral component of membrane{>sp|O14763|TR10B_HUMAN Tumor necrosis factor receptor superfamily member 10B OS=Homo sapiens OX=9606 GN=TNFRSF10B PE=1 SV=2Q86X55CARM1 CARM1_HUMAN(Histone-arginine methyltransferase CARM1regulation of growth plate cartilage chondrocyte proliferation,transcription, DNA-templated,regulation of transcription, DNA-templated,DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest,aging,positive regulation of cell proliferation,viral process,histone methylation,peptidyl-arginine methylation, to asymmetrical-dimethyl arginine,intracellular estrogen receptor signaling pathway,negative regulation of protein binding,regulation of intracellular estrogen receptor signaling pathway,histone H3-R2 methylation,histone H3-R17 methylation,cellular lipid metabolic process,positive regulation of fat cell differentiation,positive regulation of transcription from RNA polymerase II promoter,positive regulation of NF-kappaB transcription factor activity,response to cAMP,endochondral bone morphogenesis,protein localization to chromatin,regulation of mRNA binding,negative regulation of dendrite developmentGRNA polymerase II transcription coactivator activity,transcription coactivator activity,protein binding,beta-catenin binding,protein methyltransferase activity,histone-arginine N-methyltransferase activity,protein-arginine N-methyltransferase activity,ligand-dependent nuclear receptor transcription coactivator activity,protein-arginine omega-N asymmetric methyltransferase activity,histone methyltransferase activity (H3-R17 specific),histone methyltransferase activity,protein homodimerization activity,transcription regulatory region DNA binding,lysine-acetylated histone bindingTnucleus,nucleoplasm,cytoplasm,cytosol,RNA polymerase II transcription factor complexj>sp|Q86X55|CARM1_HUMAN Histone-arginine methyltransferase CARM1 OS=Homo sapiens OX=9606 GN=CARM1 PE=1 SV=3O15260SURF4 SURF4_HUMANSurfeit locus protein 4retrograde vesicle-mediated transport, Golgi to ER,Golgi organization,positive regulation of organelle organization,neutrophil degranulation,protein exit from endoplasmic reticulum,early endosome to Golgi transportGolgi membrane,endoplasmic reticulum membrane,endoplasmic reticulum-Golgi intermediate compartment,plasma membrane,integral component of membrane,transport vesicle,endoplasmic reticulum-Golgi intermediate compartment membrane,azurophil granule membraneY>sp|O15260|SURF4_HUMAN Surfeit locus protein 4 OS=Homo sapiens OX=9606 GN=SURF4 PE=1 SV=3Q14192FHL2 FHL2_HUMAN%Four and a half LIM domains protein 2~negative regulation of transcription from RNA polymerase II promoter,osteoblast differentiation,transcription, DNA-templated,response to hormone,androgen receptor signaling pathway,negative regulation of apoptotic process,positive regulation of transcription, DNA-templated,atrial cardiac muscle cell development,ventricular cardiac muscle cell development,heart trabecula formationtranscription coactivator activity,protein binding,transcription factor binding,zinc ion binding,identical protein binding,androgen receptor binding0nucleus,nucleoplasm,focal adhesion,Z disc,M bande>sp|Q14192|FHL2_HUMAN Four and a half LIM domains protein 2 OS=Homo sapiens OX=9606 GN=FHL2 PE=1 SV=3P30825SLC7A1 SL7A1_HUMAN/High affinity cationic amino acid transporter 1?transport,amino acid transport,arginine transmembrane transportiprotein binding,amino acid transmembrane transporter activity,arginine transmembrane transporter activity>plasma membrane,integral component of plasma membrane,membraner>sp|P30825|SL7A1_HUMAN High affinity cationic amino acid transporter 1 OS=Homo sapiens OX=9606 GN=SLC7A1 PE=1 SV=1Q13492PICALM PICAL_HUMAN6Phosphatidylinositol-binding clathrin assembly proteinprotein complex assembly,receptor-mediated endocytosis,axonogenesis,cell proliferation,negative regulation of gene expression,synaptic vesicle maturation,vesicle-mediated transport,endosomal transport,hemopoiesis,regulation of endocytosis,receptor internalization,regulation of protein localization,cargo loading into vesicle,positive regulation of transcription, DNA-templated,negative regulation of receptor-mediated endocytosis,clathrin coat assembly,dendrite morphogenesis,iron ion homeostasis,membrane organization,clathrin-dependent endocytosis,iron ion import into cell,positive regulation of neuron death,positive regulation of beta-amyloid formation,regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process,positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process,negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic processprotein binding,1-phosphatidylinositol binding,clathrin binding,clathrin heavy chain binding,clathrin adaptor activity,cadherin bindingnucleus,Golgi apparatus,cytosol,clathrin-coated pit,membrane,vesicle,presynaptic membrane,neuronal cell body,intracellular membrane-bounded organelle,postsynaptic membrane,neurofibrillary tangle,AP-2 adaptor comple< x,clathrin coat of coated pit,perinuclear region of cytoplasmy>sp|Q13492|PICAL_HUMAN Phosphatidylinositol-binding clathrin assembly protein OS=Homo sapiens OX=9606 GN=PICALM PE=1 SV=2P62495ETF1 ERF1_HUMAN1Eukaryotic peptide chain release factor subunit 1nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,translational termination,regulation of translational termination,protein methylationRNA binding,translation release factor activity,protein binding,translation termination factor activity,translation release factor activity, codon specific,ribosome bindingcytoplasm,cytosol,nucleusq>sp|P62495|ERF1_HUMAN Eukaryotic peptide chain release factor subunit 1 OS=Homo sapiens OX=9606 GN=ETF1 PE=1 SV=3Q9H3U1UNC45A UN45A_HUMANProtein unc-45 homolog APmuscle organ development,cell differentiation,chaperone-mediated protein folding6protein binding,cadherin binding,Hsp90 protein bindingEGolgi apparatus,cytosol,nuclear speck,perinuclear region of cytoplasm[>sp|Q9H3U1|UN45A_HUMAN Protein unc-45 homolog A OS=Homo sapiens OX=9606 GN=UNC45A PE=1 SV=1P18077RPL35A RL35A_HUMAN60S ribosomal protein L35anuclear-transcribed mRNA catabolic process, nonsense-mediated decay,rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,viral transcription,ribosomal large subunit biogenesisKtRNA binding,RNA binding,structural constituent of ribosome,protein bindingkmitochondrion,cytosol,membrane,cytosolic large ribosomal subunit,extracellular matrix,extracellular exosome]>sp|P18077|RL35A_HUMAN 60S ribosomal protein L35a OS=Homo sapiens OX=9606 GN=RPL35A PE=1 SV=2Q99805TM9SF2 TM9S2_HUMAN$Transmembrane 9 superfamily member 2Vendosome,integral component of plasma membrane,endosome membrane,extracellular exosomeg>sp|Q99805|TM9S2_HUMAN Transmembrane 9 superfamily member 2 OS=Homo sapiens OX=9606 GN=TM9SF2 PE=1 SV=1O00471EXOC5 EXOC5_HUMANExocyst complex component 5uexocytosis,post-Golgi vesicle-mediated transport,Golgi to plasma membrane transport,protein transport,vesicle docking=protein binding,Ral GTPase binding,protein N-terminus bindingexocyst,cytoplasm,cytosol]>sp|O00471|EXOC5_HUMAN Exocyst complex component 5 OS=Homo sapiens OX=9606 GN=EXOC5 PE=1 SV=1P51991HNRNPA3 ROA3_HUMAN*Heterogeneous nuclear ribonucleoprotein A3=mRNA splicing, via spliceosome,gene expression,mRNA transportbnucleotide binding,RNA binding,mRNA binding,protein binding,RNA transmembrane transporter activitynucleus,nucleoplasm,cytoplasm,intracellular ribonucleoprotein complex,ribonucleoprotein granule,neuron projection,catalytic step 2 spliceosome,messenger ribonucleoprotein complexm>sp|P51991|ROA3_HUMAN Heterogeneous nuclear ribonucleoprotein A3 OS=Homo sapiens OX=9606 GN=HNRNPA3 PE=1 SV=2Q8TCT9HM13 HM13_HUMAN$Minor histocompatibility antigen H13membrane protein proteolysis,protein homotetramerization,membrane protein proteolysis involved in retrograde protein transport, ER to cytosol,membrane protein ectodomain proteolysis,membrane protein intracellular domain proteolysisprotein binding,peptidase activity,ubiquitin protein ligase binding,aspartic endopeptidase activity, intramembrane cleaving,protein homodimerization activity]lysosomal membrane,endoplasmic reticulum,endoplasmic reticulum membrane,rough endoplasmic reticulum,plasma membrane,cell surface,membrane,Golgi-associated vesicle membrane,Derlin-1 retrotranslocation complex,integral component of cytoplasmic side of endoplasmic reticulum membrane,integral component of lumenal side of endoplasmic reticulum membraned>sp|Q8TCT9|HM13_HUMAN Minor histocompatibility antigen H13 OS=Homo sapiens OX=9606 GN=HM13 PE=1 SV=1Q07092COL16A1 COGA1_HUMANCollagen alpha-1(XVI) chaincell adhesion,integrin-mediated signaling pathway,female pregnancy,extracellular matrix organization,integrin activation,cell adhesion mediated by integrin,positive regulation of focal adhesion assembly,cellular response to amino acid stimulus integrin binding,protein bindinglextracellular region,proteinaceous extracellular matrix,collagen type XVI trimer,endoplasmic reticulum lumen_>sp|Q07092|COGA1_HUMAN Collagen alpha-1(XVI) chain OS=Homo sapiens OX=9606 GN=COL16A1 PE=1 SV=2P03956MMP1 MMP1_HUMANInterstitial collagenaseproteolysis,viral process,extracellular matrix disassembly,collagen catabolic process,positive regulation of protein oligomerization,cellular protein metabolic process,leukocyte migration|endopeptidase activity,metalloendopeptidase activity,serine-type endopeptidase activity,calcium ion binding,zinc ion binding7extracellular region,proteinaceous extracellular matrixX>sp|P03956|MMP1_HUMAN Interstitial collagenase OS=Homo sapiens OX=9606 GN=MMP1 PE=1 SV=3Q9UIA9XPO7 XPO7_HUMAN Exportin-7*protein export from nucleus,mRNA transportJnuclear export signal receptor activity,protein binding,Ran GTPase bindingnucleus,nuclear pore,cytoplasmJ>sp|Q9UIA9|XPO7_HUMAN Exportin-7 OS=Homo sapiens OX=9606 GN=XPO7 PE=1 SV=3Q8N5C1CALHM5 CAHM5_HUMAN'Calcium homeostasis modulator protein 5:ion transmembrane transport,cation transmembrane transportcation channel activity;integral component of plasma membrane,extracellular exosomej>sp|Q8N5C1|CAHM5_HUMAN Calcium homeostasis modulator protein 5 OS=Homo sapiens OX=9606 GN=CALHM5 PE=1 SV=1Q969H8MYDGF MYDGF_HUMANMyeloid-derived growth factorangiogenesis,positive regulation of protein phosphorylation,positive regulation of endothelial cell proliferation,apoptotic process,positive regulation of phosphatidylinositol 3-kinase signaling,IRE1-mediated unfolded protein response,negative regulation of apoptotic process,positive regulation of MAPK cascade,positive regulation of angiogenesis,positive regulation of transcription from RNA polymerase II promoter,positive regulation of protein kinase B signalingzextracellular space,endoplasmic reticulum lumen,endoplasmic reticulum-Golgi intermediate compartment,extracellular exosome_>sp|Q969H8|MYDGF_HUMAN Myeloid-derived growth factor OS=Homo sapiens OX=9606 GN=MYDGF PE=1 SV=1P55735SEC13 SEC13_HUMANProtein SEC13 homologantigen processing and presentation of peptide antigen via MHC class I,intracellular protein transport,sister chromatid cohesion,antigen processing and presentation of exogenous peptide antigen via MHC class II,positive regulation of TOR signaling,COPII vesicle coating,mRNA transport)protein binding,identical protein bindingGolgi membrane,nuclear envelope,nucleoplasm,endoplasmic reticulum membrane,cytosol,ER to Golgi transport vesicle membrane,nuclear pore outer ring,intracellular membrane-bounded organelle,GATOR2 complex,extracellular exosome,kinetochoreW>sp|P55735|SEC13_HUMAN Protein SEC13 homolog OS=Homo sapiens OX=9606 GN=SEC13 PE=1 SV=3Q92538GBF1 GBF1_HUMANJGolgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1Gcell activation involved in immune response,ER to Golgi vesicle-mediated transport,retrograde vesicle-mediated transport, Golgi to ER,post-Golgi vesicle-mediated transport,Golgi to endosome transport,Golgi organization,regulation of mitotic cell cycle,protein transport,viral process,neutrophil chemotaxis,regulation of ARF protein signal transduction,protein localization to Golgi apparatus,retrograde transport, endosome to Golgi,positive regulation of GTPase activity,COPI coating of Golgi vesicle,establishment of monopolar cell polarity,protein localization to endoplasmic reticulum exit site,Golgi disassembly,endoplasmic reticulum-Golgi intermediate compartment organization,reactive oxygen species biosynthetic process,protein localization to endoplasmic reticulum tubular network,regulation of protein localization to cell surfaceguanyl-nucleotide exchange factor activity,ARF guanyl-nucleotide exchange factor activity,protein binding,phosphatidylinositol-3,4,5-trisphosphate binding,phosphatidylinositol-3,5-bisphosphate bindingGolgi membrane,mitochondrion,peroxisome,endoplasmic reticulum lumen,endoplasmic reticulum-Golgi intermediate compartment,Golgi apparatus,Golgi < stack,cis-Golgi network,trans-Golgi network,lipid particle,cytosol,membrane,cell leading edge>sp|Q92538|GBF1_HUMAN Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 OS=Homo sapiens OX=9606 GN=GBF1 PE=1 SV=2Q96FQ6S100A16 S10AG_HUMANProtein S100-A16response to calcium ionQRNA binding,calcium ion binding,protein binding,protein homodimerization activity7nucleolus,cytosol,plasma membrane,extracellular exosomeT>sp|Q96FQ6|S10AG_HUMAN Protein S100-A16 OS=Homo sapiens OX=9606 GN=S100A16 PE=1 SV=1Q92905COPS5 CSN5_HUMAN"COP9 signalosome complex subunit 5protein deneddylation,nucleotide-excision repair, DNA damage recognition,transcription-coupled nucleotide-excision repair,transcription from RNA polymerase II promoter,translation,translational initiation,protein deubiquitination,positive regulation of transcription from RNA polymerase II promoter,regulation of JNK cascade,regulation of cell cycle,regulation of IRE1-mediated unfolded protein response,exosomal secretiontranscription coactivator activity,translation initiation factor activity,thiol-dependent ubiquitin-specific protease activity,protein binding,metallopeptidase activity,metal ion bindingnucleus,nucleoplasm,cytoplasm,cytosol,eukaryotic translation initiation factor 3 complex,synaptic vesicle,COP9 signalosome,cell junction,perinuclear region of cytoplasmc>sp|Q92905|CSN5_HUMAN COP9 signalosome complex subunit 5 OS=Homo sapiens OX=9606 GN=COPS5 PE=1 SV=4P52926HMGA2 HMGA2_HUMAN"High mobility group protein HMGI-C-negative regulation of transcription from RNA polymerase II promoter,epithelial to mesenchymal transition,chondrocyte differentiation,mesodermal-endodermal cell signaling,base-excision repair,chromatin organization,regulation of transcription, DNA-templated,transcription from RNA polymerase II promoter,mitotic nuclear division,mitotic G2 DNA damage checkpoint,multicellular organism development,response to virus,regulation of cell cycle process,positive regulation of gene expression,chromosome condensation,chromosome breakage,heterochromatin assembly,histone H2A-S139 phosphorylation,senescence-associated heterochromatin focus assembly,endodermal cell differentiation,chondrocyte proliferation,regulation of growth,DNA damage response, detection of DNA damage,positive regulation of apoptotic process,negative regulation of apoptotic process,negative regulation of DNA binding,negative regulation by host of viral transcription,fat cell differentiation,negative regulation of single stranded viral RNA replication via double stranded DNA intermediate,negative regulation of transcription, DNA-templated,positive regulation of transcription, DNA-templated,positive regulation of transcription from RNA polymerase II promoter,mesodermal cell differentiation,mesenchymal cell differentiation,stem cell differentiation,cell division,positive regulation of cell cycle arrest,oncogene-induced cell senescence,regulation of stem cell population maintenance,positive regulation of stem cell proliferation,positive regulation of transcription regulatory region DNA binding,positive regulation of cellular response to X-ray,positive regulation of cellular senescence,positive regulation of response to DNA damage stimulus,negative regulation of double-strand break repair via nonhomologous end joining,regulation of cellular response to drugregulatory region DNA binding,core promoter binding,transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding,transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding,DNA binding,AT DNA binding,DNA-(apurinic or apyrimidinic site) lyase activity,DNA-dependent protein kinase activity,protein binding,transcription factor binding,DNA binding, bending,nucleosomal DNA binding,cAMP response element binding,MH2 domain binding,MH1 domain binding,SMAD binding,5'-deoxyribose-5-phosphate lyase activity,C2H2 zinc finger domain binding,transcription factor activity, transcription factor binding{nuclear chromosome,nucleus,nucleoplasm,protein-DNA complex,senescence-associated heterochromatin focus,SMAD protein complexd>sp|P52926|HMGA2_HUMAN High mobility group protein HMGI-C OS=Homo sapiens OX=9606 GN=HMGA2 PE=1 SV=1P07225PROS1 PROS_HUMANVitamin K-dependent protein Splatelet degranulation,signal peptide processing,ER to Golgi vesicle-mediated transport,blood coagulation,negative regulation of endopeptidase activity,peptidyl-glutamic acid carboxylation,regulation of complement activation,fibrinolysis,leukocyte migration4endopeptidase inhibitor activity,calcium ion bindingGolgi membrane,extracellular region,extracellular space,endoplasmic reticulum membrane,Golgi lumen,plasma membrane,platelet alpha granule lumen,extracellular exosome,blood microparticle^>sp|P07225|PROS_HUMAN Vitamin K-dependent protein S OS=Homo sapiens OX=9606 GN=PROS1 PE=1 SV=1Q14563SEMA3A SEM3A_HUMAN Semaphorin-3Aneuron migration,regulation of heart rate,apoptotic process,axon guidance,axonal fasciculation,negative regulation of epithelial cell migration,negative regulation of neuron projection development,facial nerve structural organization,trigeminal nerve structural organization,nerve development,olfactory bulb development,branchiomotor neuron axon guidance,gonadotrophin-releasing hormone neuronal migration to the hypothalamus,ventral trunk neural crest cell migration,sympathetic nervous system development,dendrite morphogenesis,regulation of axon extension involved in axon guidance,negative regulation of axon extension involved in axon guidance,axon extension involved in axon guidance,sensory system development,negative chemotaxis,axonogenesis involved in innervation,dichotomous subdivision of terminal units involved in salivary gland branching,sympathetic ganglion development,trigeminal ganglion development,semaphorin-plexin signaling pathway,sympathetic neuron projection extension,sympathetic neuron projection guidance,neural crest cell migration involved in autonomic nervous system development,semaphorin-plexin signaling pathway involved in neuron projection guidance,semaphorin-plexin signaling pathway involved in axon guidance,neural crest cell migration involved in sympathetic nervous system development,facioacoustic ganglion development,positive regulation of male gonad development,positive regulation of neuron migrationFsemaphorin receptor binding,neuropilin binding,chemorepellent activity6extracellular region,extracellular space,axon,dendriteP>sp|Q14563|SEM3A_HUMAN Semaphorin-3A OS=Homo sapiens OX=9606 GN=SEMA3A PE=1 SV=1Q9NZI8IGF2BP1 IF2B1_HUMAN3Insulin-like growth factor 2 mRNA-binding protein 1gene expression,regulation of mRNA stability involved in response to stress,negative regulation of translation,pallium cell proliferation in forebrain,regulation of cytokine biosynthetic process,mRNA transport,CRD-mediated mRNA stabilization,neuronal stem cell population maintenancenucleotide binding,RNA binding,mRNA binding,mRNA 3'-UTR binding,protein binding,translation regulator activity,mRNA 5'-UTR bindingnucleoplasm,cytoplasm,cytosol,cytoplasmic stress granule,lamellipodium,filopodium,axon,growth cone,intracellular ribonucleoprotein complex,dendritic spine,perinuclear region of cytoplasm,CRD-mediated mRNA stability complexw>sp|Q9NZI8|IF2B1_HUMAN Insulin-like growth factor 2 mRNA-binding protein 1 OS=Homo sapiens OX=9606 GN=IGF2BP1 PE=1 SV=2Q12805EFEMP1 FBLN3_HUMAN:EGF-containing fibulin-like extracellular matrix protein 1regulation of transcription, DNA-templated,epidermal growth factor receptor signaling pathway,visual perception,peptidyl-tyrosine phosphorylation,negative regulation of chondrocyte differentiation,camera-type eye development,embryonic eye morphogenesis,post-embryonic eye morphogenesisepidermal growth factor-activated receptor activity,epidermal growth factor receptor binding,calcium ion binding,protein binding,growth factor activityvextracellular region,proteinaceous extracellular matrix,extracellular space,extracellular exosome,extracellular matrix}>sp|Q12805|F< BLN3_HUMAN EGF-containing fibulin-like extracellular matrix protein 1 OS=Homo sapiens OX=9606 GN=EFEMP1 PE=1 SV=2P84098RPL19 RL19_HUMAN60S ribosomal protein L19nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,viral transcription,liver regenerationuRNA binding,structural constituent of ribosome,protein binding,large ribosomal subunit rRNA binding,5.8S rRNA bindingAcytosol,focal adhesion,membrane,cytosolic large ribosomal subunitZ>sp|P84098|RL19_HUMAN 60S ribosomal protein L19 OS=Homo sapiens OX=9606 GN=RPL19 PE=1 SV=1P56192MARS1 SYMC_HUMAN$Methionine--tRNA ligase, cytoplasmicItRNA aminoacylation for protein translation,methionyl-tRNA aminoacylation8tRNA binding,methionine-tRNA ligase activity,ATP binding&cytosol,membrane,extracellular exosomee>sp|P56192|SYMC_HUMAN Methionine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=MARS1 PE=1 SV=2P11387TOP1 TOP1_HUMANDNA topoisomerase 1DNA replication,DNA topological change,chromatin remodeling,chromosome segregation,circadian rhythm,programmed cell death,viral process,phosphorylation,protein sumoylation,circadian regulation of gene expression,embryonic cleavage,response to drugcore promoter sequence-specific DNA binding,DNA binding,chromatin binding,RNA binding,DNA topoisomerase type I activity,protein bindingcytoplasmic mRNA processing body,fibrillar center,nucleus,nucleoplasm,nucleolus,replication fork protection complex,perikaryon,nuclear chromosomeS>sp|P11387|TOP1_HUMAN DNA topoisomerase 1 OS=Homo sapiens OX=9606 GN=TOP1 PE=1 SV=2Q15036SNX17 SNX17_HUMANSorting nexin-17cardiac septum development,cholesterol catabolic process,intracellular protein transport,receptor-mediated endocytosis,signal transduction,endosomal transport,regulation of endocytosis,aorta development,coronary vasculature development,retrograde transport, endosome to plasma membranereceptor binding,protein binding,protein C-terminus binding,phosphatidylinositol binding,low-density lipoprotein particle receptor bindingendosome,early endosome,Golgi apparatus,cytosol,endosome membrane,membrane,cytoplasmic vesicle membrane,cytoplasmic vesicle,intracellular membrane-bounded organelle,protein complexR>sp|Q15036|SNX17_HUMAN Sorting nexin-17 OS=Homo sapiens OX=9606 GN=SNX17 PE=1 SV=1Q1KMD3HNRNPUL2 HNRL2_HUMAN8Heterogeneous nuclear ribonucleoprotein U-like protein 2 RNA bindingnucleus,nucleoplasm,membrane}>sp|Q1KMD3|HNRL2_HUMAN Heterogeneous nuclear ribonucleoprotein U-like protein 2 OS=Homo sapiens OX=9606 GN=HNRNPUL2 PE=1 SV=1O95832CLDN1 CLD1_HUMAN Claudin-1Haging,establishment of blood-nerve barrier,response to toxic substance,calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules,response to lipopolysaccharide,hyperosmotic salinity response,cell-cell junction organization,response to ethanol,viral entry into host cell,protein homooligomerization,protein heterooligomerization,establishment of skin barrier,drug transport across blood-nerve barrier,response to interleukin-18,bicellular tight junction assembly,cellular response to lead ion,cellular response to interferon-gamma,cellular response to tumor necrosis factor,response to dexamethasone,cellular response to transforming growth factor beta stimulus,establishment of endothelial intestinal barrier,liver regeneration,positive regulation of bicellular tight junction assembly,cellular response to butyrate^virus receptor activity,structural molecule activity,protein binding,identical protein bindingcytoplasm,integral component of plasma membrane,bicellular tight junction,integral component of membrane,apical plasma membrane,lateral plasma membraneJ>sp|O95832|CLD1_HUMAN Claudin-1 OS=Homo sapiens OX=9606 GN=CLDN1 PE=1 SV=1Q8TEX9IPO4 IPO4_HUMAN Importin-4protein import into nucleus, translocation,DNA replication-dependent nucleosome assembly,DNA replication-independent nucleosome assembly,NLS-bearing protein import into nucleus,ribosomal protein import into nucleus,protein transporteprotein binding,nuclear localization sequence binding,Ran GTPase binding,protein transporter activitydnuclear chromatin,cytoplasm,membrane,nuclear membrane,nuclear periphery,protein complex,nuclear poreJ>sp|Q8TEX9|IPO4_HUMAN Importin-4 OS=Homo sapiens OX=9606 GN=IPO4 PE=1 SV=2P15170GSPT1 ERF3A_HUMANAEukaryotic peptide chain release factor GTP-binding subunit ERF3AG1/S transition of mitotic cell cycle,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,cytoplasmic translational termination,translational termination,protein methylation[RNA binding,translation release factor activity,GTPase activity,protein binding,GTP binding8intracellular,cytosol,translation release factor complex>sp|P15170|ERF3A_HUMAN Eukaryotic peptide chain release factor GTP-binding subunit ERF3A OS=Homo sapiens OX=9606 GN=GSPT1 PE=1 SV=1O43488AKR7A2 ARK72_HUMAN(Aflatoxin B1 aldehyde reductase member 2carbohydrate metabolic process,cellular aldehyde metabolic process,xenobiotic metabolic process,daunorubicin metabolic process,doxorubicin metabolic process,oxidation-reduction processalditol:NADP+ 1-oxidoreductase activity,aldo-keto reductase (NADP) activity,protein binding,electron carrier activity,phenanthrene-9,10-epoxide hydrolase activity-Golgi apparatus,cytosol,extracellular exosomek>sp|O43488|ARK72_HUMAN Aflatoxin B1 aldehyde reductase member 2 OS=Homo sapiens OX=9606 GN=AKR7A2 PE=1 SV=3P27816MAP4 MAP4_HUMAN Microtubule-associated protein 4mitotic spindle organization,neuron projection development,microtubule sliding,establishment of spindle orientation,cell division,negative regulation of nonmotile primary cilium assemblyLRNA binding,structural molecule activity,protein binding,microtubule bindingcytoplasm,microtubule,microtubule associated complex,axoneme,postsynaptic density,neuron projection,extracellular exosome,mitotic spindle`>sp|P27816|MAP4_HUMAN Microtubule-associated protein 4 OS=Homo sapiens OX=9606 GN=MAP4 PE=1 SV=3P30043BLVRB BLVRB_HUMANFlavin reductase (NADPH)Cbiliverdin reductase activity,riboflavin reductase (NADPH) activityInucleoplasm,cytosol,plasma membrane,terminal bouton,extracellular exosomeZ>sp|P30043|BLVRB_HUMAN Flavin reductase (NADPH) OS=Homo sapiens OX=9606 GN=BLVRB PE=1 SV=3P31949S100A11 S10AB_HUMANProtein S100-A11signal transduction,negative regulation of DNA replication,negative regulation of cell proliferation,neutrophil degranulation,cell-cell adhesioncalcium ion binding,protein binding,protein homodimerization activity,S100 protein binding,calcium-dependent protein binding,cadherin binding involved in cell-cell adhesionruffle,extracellular region,extracellular space,nucleus,cytoplasm,cell-cell adherens junction,secretory granule lumen,extracellular exosomeT>sp|P31949|S10AB_HUMAN Protein S100-A11 OS=Homo sapiens OX=9606 GN=S100A11 PE=1 SV=2P15586GNS GNS_HUMANN-acetylglucosamine-6-sulfatase^glycosaminoglycan catabolic process,keratan sulfate catabolic process,neutrophil degranulationlprotein binding,N-acetylglucosamine-6-sulfatase activity,sulfuric ester hydrolase activity,metal ion bindingoextracellular region,azurophil granule lumen,lysosomal lumen,extracellular exosome,ficolin-1-rich granule lumen]>sp|P15586|GNS_HUMAN N-acetylglucosamine-6-sulfatase OS=Homo sapiens OX=9606 GN=GNS PE=1 SV=3Q13409DYNC1I2 DC1I2_HUMAN)Cytoplasmic dynein 1 intermediate chain 2G2/M transition of mitotic cell cycle,ER to Golgi vesicle-mediated transport,microtubule-based movement,viral process,antigen processing and presentation of exogenous peptide antigen via MHC class II,ciliary basal body docking*microtubule motor activity,protein bindingKcytoplasm,centrosome,cytosol,cytoplasmic dynein complex,microtubule,vesiclem>sp|Q13409|DC1I2_HUMAN Cytoplasmic dynein 1 intermediate chain 2 OS=Homo sapiens OX=9606 GN=DYNC1I2 PE=1 SV=3P62851RPS25 RS25_HUMAN40S ribosomal protein S25RNA binding,protein bindi< ngnucleus,nucleoplasm,nucleolus,cytosol,ribosome,small ribosomal subunit,cytosolic small ribosomal subunit,extracellular matrix,extracellular exosomeZ>sp|P62851|RS25_HUMAN 40S ribosomal protein S25 OS=Homo sapiens OX=9606 GN=RPS25 PE=1 SV=1P09493TPM1 TPM1_HUMANTropomyosin alpha-1 chain in utero embryonic development,positive regulation of heart rate by epinephrine,movement of cell or subcellular component,muscle contraction,regulation of muscle contraction,cytoskeleton organization,actin filament organization,regulation of heart contraction,regulation of cell shape,muscle filament sliding,negative regulation of cell migration,ruffle organization,positive regulation of ATPase activity,cellular response to reactive oxygen species,wound healing,sarcomere organization,positive regulation of cell adhesion,positive regulation of stress fiber assembly,ventricular cardiac muscle tissue morphogenesis,cardiac muscle contraction,negative regulation of vascular smooth muscle cell proliferation,negative regulation of vascular associated smooth muscle cell migrationactin binding,structural constituent of cytoskeleton,protein binding,cytoskeletal protein binding,structural constituent of muscle,actin filament bindingstress fiber,cytosol,cytoskeleton,muscle thin filament tropomyosin,actin filament,actin cytoskeleton,sarcomere,filamentous actin,bleb,ruffle membraneY>sp|P09493|TPM1_HUMAN Tropomyosin alpha-1 chain OS=Homo sapiens OX=9606 GN=TPM1 PE=1 SV=2Q92878RAD50 RAD50_HUMANDNA repair protein RAD50regulation of mitotic recombination,telomere maintenance via recombination,telomere maintenance,double-strand break repair via homologous recombination,DNA double-strand break processing,DNA synthesis involved in DNA repair,strand displacement,DNA replication,DNA repair,double-strand break repair,double-strand break repair via nonhomologous end joining,DNA recombination,cellular response to DNA damage stimulus,telomere maintenance via telomerase,reciprocal meiotic recombination,viral process,telomeric 3' overhang formation,positive regulation of protein autophosphorylation,positive regulation of telomere maintenance,DNA duplex unwinding,positive regulation of kinase activity,nucleotide phosphorylation,chromosome organization involved in meiotic cell cycle,nucleic acid phosphodiester bond hydrolysis,regulation of signal transduction by p53 class mediator,negative regulation of telomere cappingDDNA binding,double-stranded telomeric DNA binding,adenylate kinase activity,protein binding,ATP binding,protein binding, bridging,single-stranded telomeric DNA binding,metal ion binding,G-quadruplex DNA binding,single-stranded DNA endodeoxyribonuclease activity,ATP-dependent DNA helicase activity,3'-5' exonuclease activitynuclear chromosome, telomeric region,nuclear chromatin,condensed nuclear chromosome,nucleoplasm,membrane,Mre11 complex,site of double-strand breakZ>sp|Q92878|RAD50_HUMAN DNA repair protein RAD50 OS=Homo sapiens OX=9606 GN=RAD50 PE=1 SV=1Q9P2E9RRBP1 RRBP1_HUMANRibosome-binding protein 18osteoblast differentiation,translation,protein transportRNA binding,receptor activity\endoplasmic reticulum,ribosome,membrane,integral component of endoplasmic reticulum membrane\>sp|Q9P2E9|RRBP1_HUMAN Ribosome-binding protein 1 OS=Homo sapiens OX=9606 GN=RRBP1 PE=1 SV=5P78344EIF4G2 IF4G2_HUMAN2Eukaryotic translation initiation factor 4 gamma 2translational initiation,regulation of translational initiation,cell cycle arrest,cell death,negative regulation of autophagy,positive regulation of cell growth,cellular macromolecule biosynthetic process|RNA binding,translation initiation factor activity,protein binding,translation factor activity, RNA binding,cadherin binding`cytosol,cell-cell adherens junction,membrane,eukaryotic translation initiation factor 4F complexu>sp|P78344|IF4G2_HUMAN Eukaryotic translation initiation factor 4 gamma 2 OS=Homo sapiens OX=9606 GN=EIF4G2 PE=1 SV=1P54577YARS1 SYYC_HUMAN"Tyrosine--tRNA ligase, cytoplasmicmtRNA aminoacylation for protein translation,tyrosyl-tRNA aminoacylation,apoptotic process,signal transductiontRNA binding,RNA binding,tyrosine-tRNA ligase activity,signal transducer activity,interleukin-8 receptor binding,protein binding,ATP bindingextracellular space,cytoplasm,cytosol,nuclear body,aminoacyl-tRNA synthetase multienzyme complex,methionyl glutamyl tRNA synthetase complexc>sp|P54577|SYYC_HUMAN Tyrosine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=YARS1 PE=1 SV=4Q9NR50EIF2B3 EI2BG_HUMAN2Translation initiation factor eIF-2B subunit gammatranslational initiation,response to heat,response to glucose,oligodendrocyte development,hippocampus development,negative regulation of translational initiation in response to stress,response to peptide hormone,positive regulation of GTPase activity,cellular response to stimulusprotein binding,nucleotidyltransferase activity,translation initiation factor activity,guanyl-nucleotide exchange factor activity,translation factor activity, RNA bindingEcytoplasm,cytosol,eukaryotic translation initiation factor 2B complexu>sp|Q9NR50|EI2BG_HUMAN Translation initiation factor eIF-2B subunit gamma OS=Homo sapiens OX=9606 GN=EIF2B3 PE=1 SV=1Q9UMS4PRPF19 PRP19_HUMANPre-mRNA-processing factor 19protein polyubiquitination,spliceosomal tri-snRNP complex assembly,spliceosomal complex assembly,generation of catalytic spliceosome for first transesterification step,mRNA splicing, via spliceosome,inner cell mass cell proliferation,transcription-coupled nucleotide-excision repair,double-strand break repair via nonhomologous end joining,lipid biosynthetic process,proteasomal protein catabolic process,cellular protein localization,negative regulation of neuron differentiation,positive regulation of mRNA splicing, via spliceosome,positive regulation of astrocyte differentiation,protein K63-linked ubiquitination,signal transduction involved in DNA damage checkpointoprotein binding,ubiquitin-ubiquitin ligase activity,identical protein binding,ubiquitin protein ligase activityPrp19 complex,nucleus,nucleoplasm,cytoplasm,lipid particle,spindle,membrane,nuclear speck,site of double-strand break,U2-type catalytic step 1 spliceosome,catalytic step 2 spliceosome,DNA replication factor A complex`>sp|Q9UMS4|PRP19_HUMAN Pre-mRNA-processing factor 19 OS=Homo sapiens OX=9606 GN=PRPF19 PE=1 SV=1Q15029EFTUD2 U5S1_HUMAN4116 kDa U5 small nuclear ribonucleoprotein componentimRNA splicing, via spliceosome,mRNA processing,RNA splicing,cellular response to drug,response to cocaine7RNA binding,GTPase activity,protein binding,GTP binding|nucleoplasm,spliceosomal complex,cytosol,Cajal body,membrane,nuclear speck,extracellular matrix,catalytic step 2 spliceosomev>sp|Q15029|U5S1_HUMAN 116 kDa U5 small nuclear ribonucleoprotein component OS=Homo sapiens OX=9606 GN=EFTUD2 PE=1 SV=1 O00148;Q13838 DDX39A;DDX39BDX39A_HUMAN;DX39B_HUMANAATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39BkmRNA splicing, via spliceosome,termination of RNA polymerase II transcription,RNA export from nucleus,mRNA export from nucleus,cellular response to DNA damage stimulus,regulation of gene expression,RNA secondary structure unwinding,mRNA 3'-end processing;spliceosomal complex assembly,mRNA splicing, via spliceosome,liver development,termination of RNA polymerase II transcription,RNA export from nucleus,mRNA export from nucleus,RNA splicing,RNA secondary structure unwinding,mRNA 3'-end processing,positive regulation of DNA-templated transcription, elongation,positive regulation of translation,viral mRNA export from host cell nucleus,positive regulation of cell growth involved in cardiac muscle cell development,positive regulation of vascular smooth muscle cell proliferation,negative regulation of DNA damage checkpoint,positive regulation of DNA biosynthetic processaRNA binding,ATP-dependent RNA helicase activity,protein binding,ATP binding,ATPase activity,identical protein binding;RNA binding,ATP-dependent RNA helicase activity,protein binding,ATP binding,RNA-dependent ATPase activity,ATPase activity,U6 snRN< A binding,U4 snRNA binding,protein complex binding,identical protein binding,ATP-dependent protein bindingnucleus,nucleoplasm,spliceosomal complex,membrane,nuclear speck,cytoplasm;transcription export complex,nucleus,nucleoplasm,spliceosomal complex,nuclear matrix,nuclear speck,U4 snRNP,U6 snRNP,cytoplasm>sp|O00148|DX39A_HUMAN ATP-dependent RNA helicase DDX39A OS=Homo sapiens OX=9606 GN=DDX39A PE=1 SV=2;>sp|Q13838|DX39B_HUMAN Spliceosome RNA helicase DDX39B OS=Homo sapiens OX=9606 GN=DDX39B PE=1 SV=1Q71UM5RPS27L RS27L_HUMAN40S ribosomal protein S27-likeKribosomal small subunit assembly,DNA repair,translation,activation of cysteine-type endopeptidase activity involved in apoptotic process,cellular response to DNA damage stimulus,mitotic G1 DNA damage checkpoint,intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator,positive regulation of translationRNA binding,structural constituent of ribosome,protein binding,translation activator activity,cysteine-type endopeptidase activator activity involved in apoptotic process,metal ion binding)nucleus,cytosolic small ribosomal subunita>sp|Q71UM5|RS27L_HUMAN 40S ribosomal protein S27-like OS=Homo sapiens OX=9606 GN=RPS27L PE=1 SV=3Q9Y2A7NCKAP1 NCKP1_HUMANNck-associated protein 1Kapoptotic process,central nervous system development,positive regulation of lamellipodium assembly,viral process,Rac protein signal transduction,Fc-gamma receptor signaling pathway involved in phagocytosis,vascular endothelial growth factor receptor signaling pathway,positive regulation of Arp2/3 complex-mediated actin nucleation:protein binding,protein complex binding,Rac GTPase bindingocytosol,focal adhesion,integral component of membrane,SCAR complex,lamellipodium membrane,extracellular exosome[>sp|Q9Y2A7|NCKP1_HUMAN Nck-associated protein 1 OS=Homo sapiens OX=9606 GN=NCKAP1 PE=1 SV=1Q9UN70PCDHGC3 PCDGK_HUMANProtocadherin gamma-C3cell adhesion,homophilic cell adhesion via plasma membrane adhesion molecules,cell-cell signaling,nervous system development,calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules,synapse organizationDintegral component of plasma membrane,membrane,extracellular exosomeZ>sp|Q9UN70|PCDGK_HUMAN Protocadherin gamma-C3 OS=Homo sapiens OX=9606 GN=PCDHGC3 PE=1 SV=1Q9HAU4SMURF2 SMUF2_HUMAN"E3 ubiquitin-protein ligase SMURF2[negative regulation of transcription from RNA polymerase II promoter,protein polyubiquitination,ubiquitin-dependent protein catabolic process,protein deubiquitination,regulation of transforming growth factor beta receptor signaling pathway,BMP signaling pathway,negative regulation of transforming growth factor beta receptor signaling pathway,ubiquitin-dependent SMAD protein catabolic process,negative regulation of transcription, DNA-templated,Wnt signaling pathway, planar cell polarity pathway,positive regulation of canonical Wnt signaling pathway,positive regulation of trophoblast cell migrationubiquitin-protein transferase activity,transforming growth factor beta receptor binding,protein binding,identical protein binding,SMAD binding,ubiquitin protein ligase activity`ubiquitin ligase complex,nucleus,nucleoplasm,cytosol,plasma membrane,nuclear speck,membrane rafte>sp|Q9HAU4|SMUF2_HUMAN E3 ubiquitin-protein ligase SMURF2 OS=Homo sapiens OX=9606 GN=SMURF2 PE=1 SV=1Q7L2H7EIF3M EIF3M_HUMAN4Eukaryotic translation initiation factor 3 subunit M=cytoplasmic translational initiation,translational initiation\protein binding,translation initiation factor binding,translation initiation factor activitytcytosol,eukaryotic translation initiation factor 3 complex,eukaryotic translation initiation factor 3 complex, eIF3mv>sp|Q7L2H7|EIF3M_HUMAN Eukaryotic translation initiation factor 3 subunit M OS=Homo sapiens OX=9606 GN=EIF3M PE=1 SV=1P19801AOC1 AOC1_HUMAN5Amiloride-sensitive amine oxidase [copper-containing]3xenobiotic metabolic process,amine metabolic process,cellular response to copper ion starvation,response to drug,neutrophil degranulation,response to antibiotic,oxidation-reduction process,cellular response to copper ion,cellular response to histamine,cellular response to heparin,cellular response to azideJreceptor activity,copper ion binding,calcium ion binding,primary amine oxidase activity,drug binding,heparin binding,zinc ion binding,protein complex binding,protein homodimerization activity,quinone binding,diamine oxidase activity,histamine oxidase activity,methylputrescine oxidase activity,propane-1,3-diamine oxidase activityextracellular region,extracellular space,peroxisome,plasma membrane,bicellular tight junction,specific granule lumen,extracellular exosomeu>sp|P19801|AOC1_HUMAN Amiloride-sensitive amine oxidase [copper-containing] OS=Homo sapiens OX=9606 GN=AOC1 PE=1 SV=4P49184DNASE1L1 DNSL1_HUMANDeoxyribonuclease-1-like 1pDNA metabolic process,DNA catabolic process,neutrophil degranulation,nucleic acid phosphodiester bond hydrolysis<DNA binding,endonuclease activity,deoxyribonuclease activityWextracellular region,endoplasmic reticulum,specific granule lumen,extracellular exosome_>sp|P49184|DNSL1_HUMAN Deoxyribonuclease-1-like 1 OS=Homo sapiens OX=9606 GN=DNASE1L1 PE=1 SV=1P31942HNRNPH3 HNRH3_HUMAN*Heterogeneous nuclear ribonucleoprotein H3ZmRNA splicing, via spliceosome,RNA processing,RNA splicing,epithelial cell differentiation.nucleotide binding,RNA binding,protein binding(nucleus,nucleoplasm,spliceosomal complexn>sp|P31942|HNRH3_HUMAN Heterogeneous nuclear ribonucleoprotein H3 OS=Homo sapiens OX=9606 GN=HNRNPH3 PE=1 SV=2P26572MGAT1 MGAT1_HUMANFAlpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase}in utero embryonic development,carbohydrate metabolic process,UDP-N-acetylglucosamine catabolic process,protein glycosylationalpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity,acetylglucosaminyltransferase activity,metal ion bindingbGolgi membrane,membrane,integral component of membrane,extracellular exosome,extracellular vesicle>sp|P26572|MGAT1_HUMAN Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase OS=Homo sapiens OX=9606 GN=MGAT1 PE=1 SV=2Q9H9T3ELP3 ELP3_HUMANElongator complex protein 3"neuron migration,regulation of transcription from RNA polymerase II promoter,transcription elongation from RNA polymerase II promoter,central nervous system development,positive regulation of cell migration,histone H3 acetylation,histone H4 acetylation,regulation of protein kinase activityprotein binding,phosphorylase kinase regulator activity,H3 histone acetyltransferase activity,H4 histone acetyltransferase activity,metal ion binding,iron-sulfur cluster binding,RNA polymerase II core bindingzhistone acetyltransferase complex,nucleolus,cytoplasm,transcription elongation factor complex,Elongator holoenzyme complex[>sp|Q9H9T3|ELP3_HUMAN Elongator complex protein 3 OS=Homo sapiens OX=9606 GN=ELP3 PE=1 SV=2P01031C5 CO5_HUMAN Complement C5Zactivation of MAPK activity,in utero embryonic development,chemotaxis,response to stress,inflammatory response,complement activation,complement activation, alternative pathway,complement activation, classical pathway,cell surface receptor signaling pathway,G-protein coupled receptor signaling pathway,positive regulation of vascular endothelial growth factor production,negative regulation of macrophage chemotaxis,negative regulation of endopeptidase activity,cytolysis,regulation of complement activation,positive regulation of angiogenesis,cell chemotaxis,positive regulation of chemokine secretionTendopeptidase inhibitor activity,receptor binding,protein binding,chemokine activityVextracellular region,membrane attack complex,extracellular space,extracellular exosomeJ>sp|P01031|CO5_HUMAN Complement C5 OS=Homo sapiens OX=9606 GN=C5 PE=1 SV=4P23510TNFSF4 TNFL4_HUMAN1Tumor necrosis factor ligand superfamily member 4defense response to nematode,acute inflammatory response,positive regulation of T cell cytokine production,regulation of adaptive immune response,posi< tive regulation of type 2 immune response,positive regulation of immunoglobulin mediated immune response,immune response,signal transduction,cholesterol metabolic process,positive regulation of cell proliferation,response to virus,negative regulation of interferon-gamma production,negative regulation of interleukin-17 production,positive regulation of interferon-gamma production,positive regulation of interleukin-10 production,positive regulation of interleukin-12 production,positive regulation of interleukin-13 production,positive regulation of interleukin-2 production,positive regulation of interleukin-4 production,positive regulation of interleukin-6 production,tumor necrosis factor-mediated signaling pathway,memory T cell activation,T-helper 2 cell activation,response to nitrogen dioxide,cellular response to nitrogen dioxide,CD4-positive, alpha-beta T cell costimulation,T cell proliferation,positive regulation of T cell proliferation,positive regulation of activated T cell proliferation,positive regulation of CD4-positive, alpha-beta T cell differentiation,positive regulation of memory T cell differentiation,negative regulation of sequence-specific DNA binding transcription factor activity,negative regulation of regulatory T cell differentiation,negative regulation of T-helper 1 cell differentiation,positive regulation of T-helper 2 cell differentiation,negative regulation of transcription, DNA-templated,positive regulation of alpha-beta T cell proliferation,negative regulation of cytokine secretion,regulation of inflammatory response,positive regulation of inflammatory response,positive regulation of B cell activation,positive regulation of immunoglobulin secretion,cellular response to lipopolysaccharide,cellular response to prostaglandin E stimulus,chemokine (C-C motif) ligand 11 production,positive regulation of CD4-positive, alpha-beta T cell costimulation,positive regulation of memory T cell activation,positive regulation of T-helper 2 cell activation,positive regulation of interleukin-4-dependent isotype switching to IgE isotypes|receptor binding,cytokine activity,tumor necrosis factor receptor binding,tumor necrosis factor receptor superfamily bindingVextracellular space,plasma membrane,integral component of plasma membrane,cell surfacet>sp|P23510|TNFL4_HUMAN Tumor necrosis factor ligand superfamily member 4 OS=Homo sapiens OX=9606 GN=TNFSF4 PE=1 SV=1Q00266MAT1A METK1_HUMAN,S-adenosylmethionine synthase isoform type-1sulfur amino acid metabolic process,selenium compound metabolic process,S-adenosylmethionine biosynthetic process,one-carbon metabolic process,methionine catabolic process,methylation,protein homotetramerizationmethionine adenosyltransferase activity,ATP binding,identical protein binding,metal ion binding,selenomethionine adenosyltransferase activityn>sp|Q00266|METK1_HUMAN S-adenosylmethionine synthase isoform type-1 OS=Homo sapiens OX=9606 GN=MAT1A PE=1 SV=2Q9BXS4TMEM59 TMM59_HUMANTransmembrane protein 59proteolysis,autophagy,positive regulation of autophagy,negative regulation of protein processing,negative regulation of establishment of protein localization to plasma membrane,negative regulation of protein glycosylation in Golgi&endopeptidase activity,protein bindingGolgi cis cisterna,Golgi trans cisterna,Golgi membrane,lysosome,lysosomal membrane,late endosome,Golgi medial cisterna,plasma membrane,integral component of membrane,late endosome membrane,extracellular exosome[>sp|Q9BXS4|TMM59_HUMAN Transmembrane protein 59 OS=Homo sapiens OX=9606 GN=TMEM59 PE=1 SV=1P50914RPL14 RL14_HUMAN60S ribosomal protein L14ORNA binding,structural constituent of ribosome,protein binding,cadherin bindingHcytosol,membrane,cytosolic large ribosomal subunit,extracellular exosomeZ>sp|P50914|RL14_HUMAN 60S ribosomal protein L14 OS=Homo sapiens OX=9606 GN=RPL14 PE=1 SV=4P19883FST FST_HUMAN Follistatinnegative regulation of transcription from RNA polymerase II promoter,hematopoietic progenitor cell differentiation,signal transduction,negative regulation of activin receptor signaling pathway,positive regulation of hair follicle development_signal transducer activity,protein binding,heparan sulfate proteoglycan binding,activin bindingI>sp|P19883|FST_HUMAN Follistatin OS=Homo sapiens OX=9606 GN=FST PE=1 SV=2Q9H1J7WNT5B WNT5B_HUMANProtein Wnt-5bPchondrocyte differentiation,Wnt signaling pathway,neuron differentiation,positive regulation of cell migration,wound healing,cell fate commitment,fat cell differentiation,positive regulation of fat cell differentiation,lens fiber cell development,cellular response to retinoic acid,negative regulation of canonical Wnt signaling pathway!receptor binding,frizzled bindingextracellular region,proteinaceous extracellular matrix,extracellular space,endoplasmic reticulum lumen,Golgi lumen,plasma membrane,cell surface,endocytic vesicle membrane,extracellular exosomeP>sp|Q9H1J7|WNT5B_HUMAN Protein Wnt-5b OS=Homo sapiens OX=9606 GN=WNT5B PE=2 SV=2Q10471GALNT2 GALT2_HUMAN/Polypeptide N-acetylgalactosaminyltransferase 2immunoglobulin biosynthetic process,protein O-linked glycosylation,O-glycan processing,protein O-linked glycosylation via serine,protein O-linked glycosylation via threonineqpolypeptide N-acetylgalactosaminyltransferase activity,protein binding,manganese ion binding,carbohydrate bindingGolgi membrane,endoplasmic reticulum membrane,Golgi apparatus,Golgi stack,membrane,integral component of Golgi membrane,Golgi cisterna membrane,perinuclear region of cytoplasm,extracellular exosomer>sp|Q10471|GALT2_HUMAN Polypeptide N-acetylgalactosaminyltransferase 2 OS=Homo sapiens OX=9606 GN=GALNT2 PE=1 SV=1P53680AP2S1 AP2S1_HUMANAP-2 complex subunit sigmaintracellular protein transport,receptor-mediated endocytosis,microtubule-based movement,antigen processing and presentation of exogenous peptide antigen via MHC class II,regulation of endocytosis,ephrin receptor signaling pathway,clathrin coat assembly,regulation of defense response to virus by virus,Wnt signaling pathway, planar cell polarity pathway,membrane organization,clathrin-dependent endocytosis[transporter activity,protein binding,protein transporter activity,clathrin adaptor activitycytosol,plasma membrane,AP-2 adaptor complex,endocytic vesicle membrane,clathrin-coated endocytic vesicle membrane,endolysosome membrane\>sp|P53680|AP2S1_HUMAN AP-2 complex subunit sigma OS=Homo sapiens OX=9606 GN=AP2S1 PE=1 SV=2O75116ROCK2 ROCK2_HUMANRho-associated protein kinase 2`cytokinesis,positive regulation of protein phosphorylation,protein phosphorylation,smooth muscle contraction,I-kappaB kinase/NF-kappaB signaling,Rho protein signal transduction,positive regulation of endothelial cell migration,positive regulation of gene expression,positive regulation of centrosome duplication,negative regulation of angiogenesis,regulation of cell adhesion,cortical actin cytoskeleton organization,regulation of actin cytoskeleton organization,negative regulation of myosin-light-chain-phosphatase activity,viral RNA genome replication,regulation of circadian rhythm,regulation of keratinocyte differentiation,vascular endothelial growth factor receptor signaling pathway,ephrin receptor signaling pathway,rhythmic process,centrosome duplication,regulation of stress fiber assembly,regulation of focal adhesion assembly,cellular response to testosterone stimulus,establishment of protein localization to plasma membrane,regulation of establishment of endothelial barrier,negative regulation of bicellular tight junction assembly,regulation of establishment of cell polarity,regulation of cell motilityRNA binding,protein serine/threonine kinase activity,structural molecule activity,protein binding,ATP binding,Rho GTPase binding,metal ion binding,Rho-dependent protein serine/threonine kinase activityPnucleus,centrosome,cytosol,plasma membrane,cytoplasmic ribonucleoprotein granulea>sp|O75116|ROCK2_HUMAN Rho-associated protein kinase 2 OS=Homo sapiens OX=9606 GN=ROCK2 PE=1 SV=4Q13263TRIM28 TIF1B_HUMAN(Transcription intermediary factor 1-betaBnegative regu< lation of transcription from RNA polymerase II promoter,epithelial to mesenchymal transition,DNA repair,transcription initiation from RNA polymerase II promoter,Ras protein signal transduction,embryo implantation,protein ubiquitination,chromatin modification,protein sumoylation,positive regulation of transcription factor import into nucleus,DNA methylation involved in embryo development,positive regulation of DNA binding,innate immune response,positive regulation of DNA repair,negative regulation of single stranded viral RNA replication via double stranded DNA intermediate,negative regulation of transcription, DNA-templated,positive regulation of transcription, DNA-templated,positive regulation of transcription from RNA polymerase II promoter,protein autophosphorylation,protein oligomerization,convergent extension involved in axis elongation,embryonic placenta morphogenesis,positive regulation of methylation-dependent chromatin silencing,negative regulation of DNA demethylation,negative regulation of viral release from host cell,regulation of genetic imprintingRNA polymerase II transcription coactivator activity,DNA binding,chromatin binding,transcription corepressor activity,RNA binding,protein kinase activity,ubiquitin-protein transferase activity,protein binding,zinc ion binding,ubiquitin protein ligase binding,Krueppel-associated box domain binding,chromo shadow domain binding,promoter-specific chromatin binding,transcription factor activity, sequence-specific DNA binding,sequence-specific DNA bindingnnucleus,nucleoplasm,nuclear euchromatin,nuclear heterochromatin,RNA polymerase II transcription factor complexk>sp|Q13263|TIF1B_HUMAN Transcription intermediary factor 1-beta OS=Homo sapiens OX=9606 GN=TRIM28 PE=1 SV=5P29692EEF1D EF1D_HUMANElongation factor 1-deltatranscription, DNA-templated,regulation of transcription, DNA-templated,translational elongation,signal transduction,positive regulation of I-kappaB kinase/NF-kappaB signaling,cellular response to ionizing radiationDNA binding,translation elongation factor activity,signal transducer activity,protein binding,translation factor activity, RNA binding,cadherin bindingsfibrillar center,nucleus,cytoplasm,cytosol,eukaryotic translation elongation factor 1 complex,endoplasmic reticulumZ>sp|P29692|EF1D_HUMAN Elongation factor 1-delta OS=Homo sapiens OX=9606 GN=EEF1D PE=1 SV=5Q15043SLC39A14 S39AE_HUMANMetal cation symporter ZIP14cellular zinc ion homeostasis,zinc II ion transmembrane transport,zinc II ion transmembrane import,ferrous iron transmembrane transport[zinc ion transmembrane transporter activity,ferrous iron transmembrane transporter activitylcytoplasm,plasma membrane,integral component of plasma membrane,integral component of membrane,lamellipodiuma>sp|Q15043|S39AE_HUMAN Metal cation symporter ZIP14 OS=Homo sapiens OX=9606 GN=SLC39A14 PE=1 SV=3P37235HPCAL1 HPCL1_HUMANHippocalcin-like protein 1#calcium ion binding,protein bindingmembrane,extracellular exosome]>sp|P37235|HPCL1_HUMAN Hippocalcin-like protein 1 OS=Homo sapiens OX=9606 GN=HPCAL1 PE=1 SV=3P13987CD59 CD59_HUMANCD59 glycoproteinUcell activation,negative regulation of activation of membrane attack complex,ER to Golgi vesicle-mediated transport,cell surface receptor signaling pathway,blood coagulation,regulation of complement activation,positive regulation of T cell proliferation,negative regulation of apoptotic process,neutrophil degranulation,COPII vesicle coating"complement binding,protein binding~Golgi membrane,extracellular space,endoplasmic reticulum membrane,plasma membrane,focal adhesion,cell surface,ER to Golgi transport vesicle membrane,membrane,anchored component of external side of plasma membrane,vesicle,endoplasmic reticulum-Golgi intermediate compartment membrane,specific granule membrane,sarcolemma,compact myelin,extracellular exosome,tertiary granule membraneQ>sp|P13987|CD59_HUMAN CD59 glycoprotein OS=Homo sapiens OX=9606 GN=CD59 PE=1 SV=1Q76LX8ADAMTS13 ATS13_HUMANAA disintegrin and metalloproteinase with thrombospondin motifs 13proteolysis,cell-matrix adhesion,integrin-mediated signaling pathway,glycoprotein metabolic process,response to toxic substance,response to amine,protein processing,platelet activation,response to potassium ion,protein O-linked fucosylation,peptide catabolic process,cellular response to lipopolysaccharide,cellular response to interferon-gamma,cellular response to interleukin-4,cellular response to tumor necrosis factor}metalloendopeptidase activity,integrin binding,calcium ion binding,protein binding,metallopeptidase activity,zinc ion binding_proteinaceous extracellular matrix,extracellular space,endoplasmic reticulum lumen,cell surface>sp|Q76LX8|ATS13_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 13 OS=Homo sapiens OX=9606 GN=ADAMTS13 PE=1 SV=1O76003GLRX3 GLRX3_HUMANGlutaredoxin-3regulation of the force of heart contraction,negative regulation of cardiac muscle hypertrophy,[2Fe-2S] cluster assembly,cell redox homeostasis,oxidation-reduction process,protein maturation by iron-sulfur cluster transferRNA binding,protein kinase C binding,protein binding,electron carrier activity,protein disulfide oxidoreductase activity,metal ion binding,iron-sulfur cluster binding9nucleus,cell cortex,Z disc,dendrite,extracellular exosomeP>sp|O76003|GLRX3_HUMAN Glutaredoxin-3 OS=Homo sapiens OX=9606 GN=GLRX3 PE=1 SV=2Q12965MYO1E MYO1E_HUMANUnconventional myosin-Ie?vasculogenesis,in utero embryonic development,glomerular filtration,nitrogen compound metabolic process,endocytosis,actin filament-based movement,glomerular basement membrane development,post-embryonic hemopoiesis,platelet-derived growth factor receptor signaling pathway,glomerular visceral epithelial cell developmentmicrofilament motor activity,motor activity,protein binding,calmodulin binding,ATP binding,phosphatidylinositol binding,ATPase activity, coupled,actin filament bindingcytoplasm,cytoskeleton,brush border,cell-cell junction,adherens junction,actin cytoskeleton,myosin complex,extracellular exosome,clathrin-coated endocytic vesicleZ>sp|Q12965|MYO1E_HUMAN Unconventional myosin-Ie OS=Homo sapiens OX=9606 GN=MYO1E PE=1 SV=2Q9Y6R1SLC4A4 S4A4_HUMAN/Electrogenic sodium bicarbonate cotransporter 1transport,sodium ion transport,inorganic anion transport,bicarbonate transport,sodium ion transmembrane transport,regulation of intracellular pH,anion transmembrane transportXinorganic anion exchanger activity,protein binding,sodium:bicarbonate symporter activitygplasma membrane,integral component of plasma membrane,basolateral plasma membrane,extracellular exosomeq>sp|Q9Y6R1|S4A4_HUMAN Electrogenic sodium bicarbonate cotransporter 1 OS=Homo sapiens OX=9606 GN=SLC4A4 PE=1 SV=1Q16698DECR1 DECR_HUMANC2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial5fatty acid beta-oxidation,protein homotetramerizationc2,4-dienoyl-CoA reductase (NADPH) activity,oxidoreductase activity, acting on NAD(P)H,NADPH bindingTnucleus,nucleoplasm,mitochondrion,mitochondrial matrix,cytosol,extracellular exosome>sp|Q16698|DECR_HUMAN 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial OS=Homo sapiens OX=9606 GN=DECR1 PE=1 SV=1Q16643DBN1 DREB_HUMANDrebrinactin filament organization,cell communication by chemical coupling,cell communication by electrical coupling,maintenance of protein location in cell,regulation of neuronal synaptic plasticity,regulation of dendrite development,neural precursor cell proliferation?actin binding,protein binding,profilin binding,cadherin bindingecytoplasm,plasma membrane,gap junction,cell cortex,actin cytoskeleton,dendrite,growth cone,actomyosinG>sp|Q16643|DREB_HUMAN Drebrin OS=Homo sapiens OX=9606 GN=DBN1 PE=1 SV=4Q16822PCK2 PCKGM_HUMAN6Phosphoenolpyruvate carboxykinase [GTP], mitochondrial pyruvate metabolic process,gluconeogenesis,oxaloacetate metabolic process,NADH oxidation,positive regulation of insulin secretion,response to lipopolysaccharide,cellular response to glucose stimulus,cellular response t< o tumor necrosis factor,response to dexamethasonephosphoenolpyruvate carboxykinase activity,phosphoenolpyruvate carboxykinase (GTP) activity,protein binding,GTP binding,metal ion binding8mitochondrion,mitochondrial matrix,extracellular exosomew>sp|Q16822|PCKGM_HUMAN Phosphoenolpyruvate carboxykinase [GTP], mitochondrial OS=Homo sapiens OX=9606 GN=PCK2 PE=1 SV=4Q13155AIMP2 AIMP2_HUMANEAminoacyl tRNA synthase complex-interacting multifunctional protein 2tRNA aminoacylation for protein translation,apoptotic process,negative regulation of cell proliferation,positive regulation of protein ubiquitination,Type II pneumocyte differentiation,positive regulation of neuron deathnucleus,cytosol,membrane>sp|Q13155|AIMP2_HUMAN Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 OS=Homo sapiens OX=9606 GN=AIMP2 PE=1 SV=2P04004VTN VTNC_HUMAN Vitronectinreceptor-mediated endocytosis,immune response,cell adhesion,cell-matrix adhesion,positive regulation of cell-substrate adhesion,negative regulation of endopeptidase activity,positive regulation of smooth muscle cell migration,negative regulation of blood coagulation,extracellular matrix organization,regulation of complement activation,positive regulation of vascular endothelial growth factor receptor signaling pathway,positive regulation of protein binding,cell adhesion mediated by integrin,endodermal cell differentiation,positive regulation of receptor-mediated endocytosis,oligodendrocyte differentiation,positive regulation of peptidyl-tyrosine phosphorylation,protein polymerization,smooth muscle cell-matrix adhesion,positive regulation of wound healing,liver regenerationscavenger receptor activity,integrin binding,protein binding,collagen binding,heparin binding,polysaccharide binding,identical protein binding,extracellular matrix bindingextracellular region,basement membrane,extracellular space,endoplasmic reticulum,Golgi lumen,extracellular matrix,intracellular membrane-bounded organelle,rough endoplasmic reticulum lumen,extracellular exosome,alphav-beta3 integrin-vitronectin complex,blood microparticleJ>sp|P04004|VTNC_HUMAN Vitronectin OS=Homo sapiens OX=9606 GN=VTN PE=1 SV=1P08243ASNS ASNS_HUMAN-Asparagine synthetase [glutamine-hydrolyzing]liver development,asparagine biosynthetic process,glutamine metabolic process,cellular amino acid biosynthetic process,response to light stimulus,response to mechanical stimulus,response to toxic substance,response to methotrexate,response to follicle-stimulating hormone,cellular response to hormone stimulus,PERK-mediated unfolded protein response,cellular response to glucose starvation,negative regulation of apoptotic process,response to amino acid,positive regulation of mitotic cell cycle,L-asparagine biosynthetic processasparagine synthase (glutamine-hydrolyzing) activity,protein binding,ATP binding,protein homodimerization activity,cofactor bindingm>sp|P08243|ASNS_HUMAN Asparagine synthetase [glutamine-hydrolyzing] OS=Homo sapiens OX=9606 GN=ASNS PE=1 SV=4P08708RPS17 RS17_HUMAN40S ribosomal protein S17$ribosomal small subunit assembly,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,viral transcription,erythrocyte homeostasis,ribosomal small subunit biogenesis.RNA binding,structural constituent of ribosomenucleoplasm,cytosol,ribosome,focal adhesion,membrane,cytosolic small ribosomal subunit,extracellular matrix,extracellular exosomeZ>sp|P08708|RS17_HUMAN 40S ribosomal protein S17 OS=Homo sapiens OX=9606 GN=RPS17 PE=1 SV=2P62847RPS24 RS24_HUMAN40S ribosomal protein S24\nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA),rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,viral transcription,erythrocyte homeostasis,ribosomal small subunit biogenesisgnucleotide binding,RNA binding,structural constituent of ribosome,translation initiation factor binding^nucleus,nucleoplasm,cytosol,small ribosomal subunit,membrane,cytosolic small ribosomal subunitZ>sp|P62847|RS24_HUMAN 40S ribosomal protein S24 OS=Homo sapiens OX=9606 GN=RPS24 PE=1 SV=1Q08AM6VAC14 VAC14_HUMANProtein VAC14 homologophosphatidylinositol biosynthetic process,signal transduction,viral process,regulation of lipid kinase activity!receptor activity,protein bindingqGolgi membrane,endoplasmic reticulum,endosome membrane,early endosome membrane,late endosome membrane,PAS complexW>sp|Q08AM6|VAC14_HUMAN Protein VAC14 homolog OS=Homo sapiens OX=9606 GN=VAC14 PE=1 SV=1P12429ANXA3 ANXA3_HUMAN Annexin A3phagocytosis,positive regulation of endothelial cell migration,hippocampus development,animal organ regeneration,defense response to bacterium,negative regulation of catalytic activity,neutrophil degranulation,positive regulation of angiogenesis,positive regulation of DNA metabolic process,positive regulation of sequence-specific DNA binding transcription factor activity,response to glucocorticoid,response to growth factorcalcium ion binding,calcium-dependent phospholipid binding,phospholipase A2 inhibitor activity,calcium-dependent protein bindingcytoplasm,cytosol,plasma membrane,membrane,axon,dendrite,phagocytic vesicle membrane,specific granule,neuronal cell body,extracellular exosomeL>sp|P12429|ANXA3_HUMAN Annexin A3 OS=Homo sapiens OX=9606 GN=ANXA3 PE=1 SV=3Q9UJW0DCTN4 DCTN4_HUMANDynactin subunit 4ER to Golgi vesicle-mediated transport,nuclear migration,antigen processing and presentation of exogenous peptide antigen via MHC class II*protein binding,protein N-terminus bindingPnucleus,cytoplasm,centrosome,cytosol,cytoplasmic dynein complex,dynactin complexT>sp|Q9UJW0|DCTN4_HUMAN Dynactin subunit 4 OS=Homo sapiens OX=9606 GN=DCTN4 PE=1 SV=1P58397ADAMTS12 ATS12_HUMANAA disintegrin and metalloproteinase with thrombospondin motifs 12bcell-matrix adhesion,cell migration,proteoglycan catabolic process,negative regulation of chondrocyte differentiation,regulation of inflammatory response,proteolysis involved in cellular protein catabolic process,cellular response to interleukin-1,cellular response to tumor necrosis factor,cellular response to BMP stimulus,regulation of endothelial tube morphogenesis,negative regulation of hepatocyte growth factor receptor signaling pathway,negative regulation of cellular response to vascular endothelial growth factor stimulus,negative regulation of cellular response to hepatocyte growth factor stimulus>metalloendopeptidase activity,protein binding,zinc ion binding7proteinaceous extracellular matrix,extracellular matrix>sp|P58397|ATS12_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 12 OS=Homo sapiens OX=9606 GN=ADAMTS12 PE=1 SV=2P62854RPS26 RS26_HUMAN40S ribosomal protein S26nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,viral transcription,negative regulation of RNA splicing\RNA binding,mRNA binding,structural constituent of ribosome,protein binding,cadherin bindinglnucleoplasm,cytosol,small ribosomal subunit,membrane,cytosolic small ribosomal subunit,extracellular exosomeZ>sp|P62854|RS26_HUMAN 40S ribosomal protein S26 OS=Homo sapiens OX=9606 GN=RPS26 PE=1 SV=3O15145ARPC3 ARPC3_HUMAN+Actin-related protein 2/3 complex subunit 3movement of cell or subcellular component,Arp2/3 complex-mediated actin nucleation,Fc-gamma receptor signaling pathway involved in phagocytosis,ephrin receptor signaling pathway,membrane organization,cellular response to nerve growth factor stimulusMstructural constituent of cytoskeleton,protein binding,actin filament bindingcytosol,Arp2/3 protein complex,focal adhesion,actin cytoskeleton,membrane,lamellipodium,growth cone,filamentous actin,extracellular exosomem>sp|O15145|ARPC3_HUMAN Actin-related protein 2/3 < complex subunit 3 OS=Homo sapiens OX=9606 GN=ARPC3 PE=1 SV=3P25325MPST THTM_HUMAN$3-mercaptopyruvate sulfurtransferasekidney development,liver development,cyanate catabolic process,response to toxic substance,transsulfuration,spinal cord development,hydrogen sulfide biosynthetic processnthiosulfate sulfurtransferase activity,3-mercaptopyruvate sulfurtransferase activity,identical protein bindingSmitochondrion,cytosol,cell junction,neuron projection,synapse,extracellular exosomed>sp|P25325|THTM_HUMAN 3-mercaptopyruvate sulfurtransferase OS=Homo sapiens OX=9606 GN=MPST PE=1 SV=3Q99733NAP1L4 NP1L4_HUMAN$Nucleosome assembly protein 1-like 4nucleosome assembly4RNA binding,protein binding,unfolded protein bindingnucleus,cytoplasmg>sp|Q99733|NP1L4_HUMAN Nucleosome assembly protein 1-like 4 OS=Homo sapiens OX=9606 GN=NAP1L4 PE=1 SV=1Q01432AMPD3 AMPD3_HUMANAMP deaminase 3AMP catabolic process,IMP salvage,erythrocyte homeostasis,purine-containing compound salvage,neutrophil degranulation,ADP metabolic process,ATP metabolic process,GTP metabolic process,energy homeostasis8AMP deaminase activity,protein binding,metal ion bindingQextracellular region,cytosol,secretory granule lumen,ficolin-1-rich granule lumenQ>sp|Q01432|AMPD3_HUMAN AMP deaminase 3 OS=Homo sapiens OX=9606 GN=AMPD3 PE=1 SV=1P62910RPL32 RL32_HUMAN60S ribosomal protein L32nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,viral transcription,cellular response to dexamethasone stimulus,liver regenerationZ>sp|P62910|RL32_HUMAN 60S ribosomal protein L32 OS=Homo sapiens OX=9606 GN=RPL32 PE=1 SV=2O43237DYNC1LI2 DC1L2_HUMAN/Cytoplasmic dynein 1 light intermediate chain 2microtubule cytoskeleton organization,ER to Golgi vesicle-mediated transport,microtubule-based movement,antigen processing and presentation of exogenous peptide antigen via MHC class II,centrosome localizationAmicrotubule motor activity,ATP binding,dynein heavy chain bindingBcentrosome,cytosol,cytoplasmic dynein complex,microtubule,membranet>sp|O43237|DC1L2_HUMAN Cytoplasmic dynein 1 light intermediate chain 2 OS=Homo sapiens OX=9606 GN=DYNC1LI2 PE=1 SV=1P0DP23;P0DP24;P0DP25CALM1;CALM2;CALM3#CALM1_HUMAN;CALM2_HUMAN;CALM3_HUMAN&Calmodulin-1;Calmodulin-2;Calmodulin-3;;>sp|P0DP23|CALM1_HUMAN Calmodulin-1 OS=Homo sapiens OX=9606 GN=CALM1 PE=1 SV=1;>sp|P0DP24|CALM2_HUMAN Calmodulin-2 OS=Homo sapiens OX=9606 GN=CALM2 PE=1 SV=1;>sp|P0DP25|CALM3_HUMAN Calmodulin-3 OS=Homo sapiens OX=9606 GN=CALM3 PE=1 SV=1P46776RPL27A RL27A_HUMAN60S ribosomal protein L27aHendoplasmic reticulum,cytosol,membrane,cytosolic large ribosomal subunit]>sp|P46776|RL27A_HUMAN 60S ribosomal protein L27a OS=Homo sapiens OX=9606 GN=RPL27A PE=1 SV=2P30048PRDX3 PRDX3_HUMAN7Thioredoxin-dependent peroxide reductase, mitochondrialresponse to reactive oxygen species,maternal placenta development,apoptotic process,response to oxidative stress,mitochondrion organization,positive regulation of cell proliferation,peptidyl-cysteine oxidation,myeloid cell differentiation,response to lipopolysaccharide,negative regulation of kinase activity,cellular response to oxidative stress,cellular response to reactive oxygen species,response to hydrogen peroxide,hydrogen peroxide catabolic process,negative regulation of apoptotic process,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process,cell redox homeostasis,positive regulation of NF-kappaB transcription factor activity,regulation of mitochondrial membrane potential,cellular oxidant detoxificationprotein binding,protein C-terminus binding,thioredoxin peroxidase activity,alkyl hydroperoxide reductase activity,kinase binding,protein kinase binding,identical protein binding,cysteine-type endopeptidase inhibitor activity involved in apoptotic process~cytoplasm,mitochondrion,mitochondrial matrix,early endosome,cytosol,myelin sheath,extracellular exosome,IkappaB kinase complexy>sp|P30048|PRDX3_HUMAN Thioredoxin-dependent peroxide reductase, mitochondrial OS=Homo sapiens OX=9606 GN=PRDX3 PE=1 SV=3P62888RPL30 RL30_HUMAN60S ribosomal protein L30nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,viral transcription,liver regeneration,positive regulation of selenocysteine incorporationhRNA binding,structural constituent of ribosome,protein binding,selenocysteine insertion sequence bindingtnucleus,cytosol,focal adhesion,membrane,cytosolic large ribosomal subunit,extracellular matrix,extracellular exosomeZ>sp|P62888|RL30_HUMAN 60S ribosomal protein L30 OS=Homo sapiens OX=9606 GN=RPL30 PE=1 SV=2Q9NZB2FAM120A F120A_HUMAN5Constitutive coactivator of PPAR-gamma-like protein 1(nucleus,cytosol,plasma membrane,membraney>sp|Q9NZB2|F120A_HUMAN Constitutive coactivator of PPAR-gamma-like protein 1 OS=Homo sapiens OX=9606 GN=FAM120A PE=1 SV=2P61221ABCE1 ABCE1_HUMAN*ATP-binding cassette sub-family E member 1ribosomal subunit export from nucleus,translational initiation,translational termination,viral process,transmembrane transport,negative regulation of endoribonuclease activityiron ion binding,protein binding,ATP binding,ATPase activity,ribosomal small subunit binding,endoribonuclease inhibitor activitypcytoplasm,mitochondrion,mitochondrial matrix,cytosol,membrane,eukaryotic translation initiation factor 3 complexl>sp|P61221|ABCE1_HUMAN ATP-binding cassette sub-family E member 1 OS=Homo sapiens OX=9606 GN=ABCE1 PE=1 SV=1Q9H4B7TUBB1 TBB1_HUMANTubulin beta-1 chainspindle assemblyBGTPase activity,structural constituent of cytoskeleton,GTP bindingDcytoplasm,microtubule,microtubule cytoskeleton,extracellular exosomeU>sp|Q9H4B7|TBB1_HUMAN Tubulin beta-1 chain OS=Homo sapiens OX=9606 GN=TUBB1 PE=1 SV=1Q9Y4E8USP15 UBP15_HUMAN(Ubiquitin carboxyl-terminal hydrolase 15+ubiquitin-dependent protein catabolic process,transforming growth factor beta receptor signaling pathway,protein deubiquitination,BMP signaling pathway,monoubiquitinated protein deubiquitination,histone H2B conserved C-terminal lysine deubiquitination,pathway-restricted SMAD protein phosphorylationcysteine-type endopeptidase activity,thiol-dependent ubiquitin-specific protease activity,transforming growth factor beta receptor binding,protein binding,thiol-dependent ubiquitinyl hydrolase activity,identical protein binding,SMAD binding,ubiquitinated histone bindingnucleus,cytoplasm,cytosolj>sp|Q9Y4E8|UBP15_HUMAN Ubiquitin carboxyl-terminal hydrolase 15 OS=Homo sapiens OX=9606 GN=USP15 PE=1 SV=3P84103SRSF3 SRSF3_HUMAN&Serine/arginine-rich splicing factor 3mRNA splicing, via spliceosome,termination of RNA polymerase II transcription,RNA export from nucleus,mRNA export from nucleus,mRNA 3'-end processing,regulation of mRNA splicing, via spliceosomeMnucleotide binding,RNA binding,protein binding,sequence-specific mRNA binding#nucleoplasm,cytoplasm,nuclear speckh>sp|P84103|SRSF3_HUMAN Serine/arginine-rich splicing factor 3 OS=Homo sapiens OX=9606 GN=SRSF3 PE=1 SV=1P17948FLT1 VGFR1_HUMAN-Vascular endothelial growth factor receptor 1angiogenesis,monocyte chemotaxis,transmembrane receptor protein tyrosine kinase signaling pathway,positive regulation of cell proliferation,positive regulation of phospholipase C activity,positive regulation of phosphatidylinositol 3-kinase signaling,cell migration,peptidyl-tyrosine phosphorylation,cell differentiation,positive regulation of cell migration,positive regulation of vascular endothelial growth factor receptor signaling pathway,cellular response to vascular endothelial growth factor stimulus,vascular endothelial growth factor receptor-1 signaling pathway,vascular endothelial growth factor signaling pathway,positive regulation of MAP kinase activity,positive regulation of MAPK cascade,positive regulation of phosphatidylinositol 3-kinase activit< y,positive regulation of angiogenesis,protein autophosphorylation,vascular endothelial growth factor receptor signaling pathway,blood vessel morphogenesis,embryonic morphogenesis"transmembrane receptor protein tyrosine kinase activity,vascular endothelial growth factor-activated receptor activity,protein binding,ATP binding,growth factor binding,VEGF-A-activated receptor activity,VEGF-B-activated receptor activity,placental growth factor-activated receptor activityextracellular space,endosome,plasma membrane,integral component of plasma membrane,focal adhesion,actin cytoskeleton,receptor complexn>sp|P17948|VGFR1_HUMAN Vascular endothelial growth factor receptor 1 OS=Homo sapiens OX=9606 GN=FLT1 PE=1 SV=2P55036PSMD4 PSMD4_HUMAN.26S proteasome non-ATPase regulatory subunit 4MAPK cascade,protein polyubiquitination,stimulatory C-type lectin receptor signaling pathway,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent,regulation of cellular amino acid metabolic process,negative regulation of G2/M transition of mitotic cell cycle,protein deubiquitination,anaphase-promoting complex-dependent catabolic process,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process,tumor necrosis factor-mediated signaling pathway,NIK/NF-kappaB signaling,Fc-epsilon receptor signaling pathway,proteasome-mediated ubiquitin-dependent protein catabolic process,proteasome assembly,regulation of mRNA stability,T cell receptor signaling pathway,negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition,transmembrane transport,Wnt signaling pathway, planar cell polarity pathway,regulation of transcription from RNA polymerase II promoter in response to hypoxia,negative regulation of canonical Wnt signaling pathway,positive regulation of canonical Wnt signaling pathwayKRNA binding,protein binding,polyubiquitin binding,identical protein binding{proteasome complex,nucleus,nucleoplasm,cytosol,proteasome regulatory particle, base subcomplex,proteasome accessory complexp>sp|P55036|PSMD4_HUMAN 26S proteasome non-ATPase regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PSMD4 PE=1 SV=1Q9BUD6SPON2 SPON2_HUMAN Spondin-2{mast cell mediated immunity,cell adhesion,axon guidance,opsonization,positive regulation of interleukin-6 production,positive regulation of tumor necrosis factor production,induction of bacterial agglutination,innate immune response,defense response to fungus,defense response to virus,positive regulation of macrophage cytokine production,cellular response to lipopolysaccharideLlipopolysaccharide binding,antigen binding,protein binding,metal ion bindingLproteinaceous extracellular matrix,extracellular space,extracellular exosomeK>sp|Q9BUD6|SPON2_HUMAN Spondin-2 OS=Homo sapiens OX=9606 GN=SPON2 PE=1 SV=3P55084HADHB ECHB_HUMAN0Trifunctional enzyme subunit beta, mitochondrial;fatty acid beta-oxidation,cardiolipin acyl-chain remodelingRNA binding,3-hydroxyacyl-CoA dehydrogenase activity,acetyl-CoA C-acyltransferase activity,enoyl-CoA hydratase activity,protein binding,long-chain-3-hydroxyacyl-CoA dehydrogenase activitymitochondrion,mitochondrial envelope,mitochondrial outer membrane,mitochondrial inner membrane,endoplasmic reticulum,mitochondrial nucleoid,extracellular exosomeq>sp|P55084|ECHB_HUMAN Trifunctional enzyme subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=HADHB PE=1 SV=3P17813ENG EGLN_HUMANEndoglinnchronological cell aging,patterning of blood vessels,vasculogenesis,positive regulation of protein phosphorylation,heart looping,outflow tract septum morphogenesis,epithelial to mesenchymal transition involved in endocardial cushion formation,endocardial cushion morphogenesis,cardiac ventricle morphogenesis,cardiac atrium morphogenesis,ventricular trabecula myocardium morphogenesis,cell migration involved in endocardial cushion formation,regulation of transcription, DNA-templated,cell adhesion,negative regulation of gene expression,positive regulation of pathway-restricted SMAD protein phosphorylation,regulation of transforming growth factor beta receptor signaling pathway,central nervous system vasculogenesis,negative regulation of cell migration,BMP signaling pathway,positive regulation of BMP signaling pathway,negative regulation of protein autophosphorylation,response to corticosteroid,positive regulation of collagen biosynthetic process,dorsal aorta morphogenesis,response to drug,positive regulation of angiogenesis,positive regulation of transcription from RNA polymerase II promoter,smooth muscle tissue development,artery morphogenesis,venous blood vessel morphogenesis,atrial cardiac muscle tissue morphogenesis,bone development,extracellular matrix constituent secretion,cellular response to mechanical stimulus,response to transforming growth factor beta,vascular smooth muscle cell development,positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation,positive regulation of vascular smooth muscle cell differentiation,atrioventricular canal morphogenesis,sprouting angiogenesis,regulation of cardiac muscle cell apoptotic process,endocardial cushion to mesenchymal transition,regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis,regulation of cell proliferation involved in heart morphogenesistransmembrane signaling receptor activity,transforming growth factor beta receptor, cytoplasmic mediator activity,type II transforming growth factor beta receptor binding,protein binding,galactose binding,glycosaminoglycan binding,type I transforming growth factor beta receptor binding,protein homodimerization activity,activin binding,transforming growth factor beta binding,BMP bindingextracellular space,focal adhesion,external side of plasma membrane,receptor complex,transforming growth factor beta receptor homodimeric complex,endothelial microparticleG>sp|P17813|EGLN_HUMAN Endoglin OS=Homo sapiens OX=9606 GN=ENG PE=1 SV=2Q02952AKAP12 AKA12_HUMANA-kinase anchor protein 12protein targeting,G-protein coupled receptor signaling pathway,positive regulation of protein kinase A signaling,positive regulation of cAMP biosynthetic process,regulation of protein kinase C signalingBprotein binding,adenylate cyclase binding,protein kinase A bindingIcytoplasm,cytosol,cytoskeleton,plasma membrane,focal adhesion,cell cortex]>sp|Q02952|AKA12_HUMAN A-kinase anchor protein 12 OS=Homo sapiens OX=9606 GN=AKAP12 PE=1 SV=4Q9Y617PSAT1 SERC_HUMANPhosphoserine aminotransferase=L-serine biosynthetic process,pyridoxine biosynthetic process;O-phospho-L-serine:2-oxoglutarate aminotransferase activity_>sp|Q9Y617|SERC_HUMAN Phosphoserine aminotransferase OS=Homo sapiens OX=9606 GN=PSAT1 PE=1 SV=2O00161SNAP23 SNP23_HUMAN"Synaptosomal-associated protein 23Hantigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent,histamine secretion by mast cell,post-Golgi vesicle-mediated transport,vesicle targeting,protein transport,synaptic vesicle priming,synaptic vesicle fusion to presynaptic active zone membrane,neutrophil degranulation,membrane fusion7SNAP receptor activity,protein binding,syntaxin bindingnucleoplasm,cytoplasm,plasma membrane,cell-cell adherens junction,focal adhesion,phagocytic vesicle membrane,SNARE complex,specific granule membrane,specific granule,azurophil granule,mast cell granule,neuron projection,extracellular exosome,tertiary granule membrane,presynapsee>sp|O00161|SNP23_HUMAN Synaptosomal-associated protein 23 OS=Homo sapiens OX=9606 GN=SNAP23 PE=1 SV=1Q9UL25RAB21 RAB21_HUMANRas-related protein Rab-21Hsmall GTPase mediated signal transduction,anterograde axonal transport,protein transport,regulation of exocytosis,regulation of axon extension,positive regulation of receptor-mediated endocytosis,positive regulation of dendrite morphogenesis,membrane organization,positive regulation of early endosome to late endosome transport7GTPase activity,protein bindin< g,GTP binding,GDP binding5endosome,endoplasmic reticulum membrane,trans-Golgi network,cytosol,focal adhesion,cytoplasmic side of plasma membrane,vesicle membrane,cytoplasmic vesicle membrane,early endosome membrane,cleavage furrow,Golgi cisterna membrane,extracellular exosome,cytoplasmic side of early endosome membrane,axon cytoplasm\>sp|Q9UL25|RAB21_HUMAN Ras-related protein Rab-21 OS=Homo sapiens OX=9606 GN=RAB21 PE=1 SV=3P07954FH FUMH_HUMAN!Fumarate hydratase, mitochondrial{tricarboxylic acid cycle,fumarate metabolic process,malate metabolic process,homeostasis of number of cells within a tissue+fumarate hydratase activity,protein bindingjcytoplasm,mitochondrion,mitochondrial matrix,tricarboxylic acid cycle enzyme complex,extracellular exosome_>sp|P07954|FUMH_HUMAN Fumarate hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=FH PE=1 SV=3P43490NAMPT NAMPT_HUMAN&Nicotinamide phosphoribosyltransferasesignal transduction,cell-cell signaling,female pregnancy,circadian rhythm,positive regulation of cell proliferation,response to organic cyclic compound,circadian regulation of gene expression,NAD biosynthesis via nicotinamide riboside salvage pathway,positive regulation of transcription from RNA polymerase II promoter,positive regulation of smooth muscle cell proliferation,positive regulation of nitric-oxide synthase biosynthetic process,insulin receptor signaling pathway,adipose tissue developmentnicotinate-nucleotide diphosphorylase (carboxylating) activity,cytokine activity,protein binding,drug binding,protein homodimerization activity,nicotinamide phosphoribosyltransferase activityMextracellular space,cytosol,nuclear speck,cell junction,extracellular exosomeh>sp|P43490|NAMPT_HUMAN Nicotinamide phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=NAMPT PE=1 SV=1Q6ZVX7NCCRP1 FBX50_HUMANF-box only protein 50cytoplasm,extracellular exosomeX>sp|Q6ZVX7|FBX50_HUMAN F-box only protein 50 OS=Homo sapiens OX=9606 GN=NCCRP1 PE=1 SV=1Q99829CPNE1 CPNE1_HUMANCopine-1Xtranscription, DNA-templated,regulation of transcription, DNA-templated,proteolysis,lipid metabolic process,negative regulation of gene expression,vesicle-mediated transport,regulation of I-kappaB kinase/NF-kappaB signaling,neutrophil degranulation,negative regulation of DNA binding,positive regulation of neuron differentiation,glycerophospholipid biosynthetic process,positive regulation of protein kinase B signaling,cellular response to calcium ion,negative regulation of NIK/NF-kappaB signaling,positive regulation of tumor necrosis factor-mediated signaling pathway,neuron projection extensionphosphatidylserine binding,endopeptidase activity,transporter activity,calcium ion binding,protein binding,calcium-dependent phospholipid binding,protein homodimerization activity,NF-kappaB bindingnucleus,nucleoplasm,cytoplasm,cytosol,plasma membrane,membrane,nuclear membrane,azurophil granule membrane,extracellular exosomeJ>sp|Q99829|CPNE1_HUMAN Copine-1 OS=Homo sapiens OX=9606 GN=CPNE1 PE=1 SV=1P61981YWHAG 1433G_HUMAN14-3-3 protein gammaG2/M transition of mitotic cell cycle,negative regulation of protein kinase activity,protein targeting,regulation of signal transduction,cellular response to insulin stimulus,regulation of neuron differentiation,regulation of synaptic plasticity,membrane organization,negative regulation of protein serine/threonine kinase activity,ciliary basal body docking,positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayRNA binding,protein kinase C binding,insulin-like growth factor receptor binding,protein binding,protein kinase C inhibitor activity,protein domain specific binding,receptor tyrosine kinase bindingnmitochondrion,cytosol,focal adhesion,membrane,cytoplasmic vesicle membrane,myelin sheath,extracellular exosomeV>sp|P61981|1433G_HUMAN 14-3-3 protein gamma OS=Homo sapiens OX=9606 GN=YWHAG PE=1 SV=2Q96QD8SLC38A2 S38A2_HUMAN/Sodium-coupled neutral amino acid transporter 2 amino acid transmembrane transport,sodium ion transport,amino acid transport,female pregnancy,glutamate secretion,cerebral cortex development,glycine betaine transport,alanine transport,cellular response to amino acid starvation,cellular response to mechanical stimulusPprotein binding,amino acid transmembrane transporter activity,symporter activitynplasma membrane,integral component of plasma membrane,brush border,axon,dendrite,sarcolemma,neuronal cell bodys>sp|Q96QD8|S38A2_HUMAN Sodium-coupled neutral amino acid transporter 2 OS=Homo sapiens OX=9606 GN=SLC38A2 PE=1 SV=2P04843RPN1 RPN1_HUMANHDolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1Scellular protein modification process,protein N-linked glycosylation via asparagine_RNA binding,protein binding,dolichyl-diphosphooligosaccharide-protein glycotransferase activityendoplasmic reticulum,endoplasmic reticulum membrane,rough endoplasmic reticulum,cytosol,oligosaccharyltransferase complex,membrane,integral component of membrane,extracellular matrix,melanosome>sp|P04843|RPN1_HUMAN Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 OS=Homo sapiens OX=9606 GN=RPN1 PE=1 SV=1P54619PRKAG1 AAKG1_HUMAN/5'-AMP-activated protein kinase subunit gamma-1Jregulation of glycolytic process,protein phosphorylation,fatty acid biosynthetic process,cell cycle arrest,signal transduction,spermatogenesis,positive regulation of gene expression,macroautophagy,positive regulation of protein kinase activity,regulation of signal transduction by p53 class mediator,single-organism nuclear importprotein kinase activity,cAMP-dependent protein kinase activity,protein binding,ATP binding,cAMP-dependent protein kinase regulator activity,AMP binding,protein kinase binding,ADP binding,AMP-activated protein kinase activity^nucleoplasm,cytosol,membrane,nucleotide-activated protein kinase complex,extracellular exosomer>sp|P54619|AAKG1_HUMAN 5'-AMP-activated protein kinase subunit gamma-1 OS=Homo sapiens OX=9606 GN=PRKAG1 PE=1 SV=1P04216THY1 THY1_HUMANThy-1 membrane glycoprotein&angiogenesis,negative regulation of protein kinase activity,C-terminal protein lipidation,cytoskeleton organization,single organismal cell-cell adhesion,negative regulation of cell migration,positive regulation of GTPase activity,retinal cone cell development,protein autophosphorylation,focal adhesion assembly,negative regulation of axonogenesis,T cell receptor signaling pathway,negative regulation of T cell receptor signaling pathway,positive regulation of T cell activation,positive regulation of release of sequestered calcium ion into cytosoldGTPase activator activity,integrin binding,protein binding,protein kinase binding,GPI anchor binding-extracellular region,endoplasmic reticulum,cytosol,plasma membrane,integral component of plasma membrane,focal adhesion,external side of plasma membrane,apical plasma membrane,dendrite,growth cone,anchored component of external side of plasma membrane,myelin sheath,membrane raft,extracellular exosome[>sp|P04216|THY1_HUMAN Thy-1 membrane glycoprotein OS=Homo sapiens OX=9606 GN=THY1 PE=1 SV=2P30520ADSS2 PURA2_HUMAN%Adenylosuccinate synthetase isozyme 2%immune system process,AMP biosynthetic process,aspartate metabolic process,purine ribonucleoside monophosphate biosynthetic process,response to purine-containing compound,'de novo' AMP biosynthetic process,IMP metabolic process,response to ammonium ion,cellular response to electrical stimulusfadenylosuccinate synthase activity,protein binding,GTP binding,phosphate ion binding,metal ion binding7cytoplasm,cytosol,plasma membrane,extracellular exosomeg>sp|P30520|PURA2_HUMAN Adenylosuccinate synthetase isozyme 2 OS=Homo sapiens OX=9606 GN=ADSS2 PE=1 SV=3Q15366PCBP2 PCBP2_HUMANPoly(rC)-binding protein 2hmRNA splicing, via spliceosome,gene expression,mRNA metabolic process,negative regulation of type I interferon production,viral RNA genome replication,proteasome-mediated ubiquitin-dependent protein catabolic process,innate immune response,negative regulation of defens< e response to virus,defense response to virus,IRES-dependent viral translational initiationnRNA binding,protein binding,enzyme binding,ubiquitin protein ligase binding,C-rich single-stranded DNA binding{nucleus,nucleoplasm,cytoplasm,cytosol,focal adhesion,membrane,intracellular ribonucleoprotein complex,extracellular exosome\>sp|Q15366|PCBP2_HUMAN Poly(rC)-binding protein 2 OS=Homo sapiens OX=9606 GN=PCBP2 PE=1 SV=1Q5T749KPRP KPRP_HUMAN!Keratinocyte proline-rich proteina>sp|Q5T749|KPRP_HUMAN Keratinocyte proline-rich protein OS=Homo sapiens OX=9606 GN=KPRP PE=1 SV=1Q04721NOTCH2 NOTC2_HUMAN(Neurogenic locus notch homolog protein 2cell fate determination,marginal zone B cell differentiation,pulmonary valve morphogenesis,regulation of transcription, DNA-templated,transcription initiation from RNA polymerase II promoter,apoptotic process,cell cycle arrest,Notch signaling pathway,multicellular organism development,nervous system development,negative regulation of cell proliferation,animal organ morphogenesis,cell growth,stem cell population maintenance,hemopoiesis,intracellular receptor signaling pathway,negative regulation of apoptotic process,positive regulation of Ras protein signal transduction,bone remodeling,regulation of developmental process,atrial septum morphogenesis,Notch signaling involved in heart developmentreceptor activity,calcium ion binding,protein binding,transcription factor activity, ligand-activated RNA polymerase II transcription factor bindingGolgi membrane,extracellular region,nucleus,nucleoplasm,endoplasmic reticulum membrane,plasma membrane,integral component of plasma membrane,cell surface,membrane,receptor complexk>sp|Q04721|NOTC2_HUMAN Neurogenic locus notch homolog protein 2 OS=Homo sapiens OX=9606 GN=NOTCH2 PE=1 SV=3P78417GSTO1 GSTO1_HUMAN!Glutathione S-transferase omega-1regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum,regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion,positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion,L-ascorbic acid metabolic process,methylation,xenobiotic catabolic process,oxidation-reduction process,negative regulation of ryanodine-sensitive calcium-release channel activity,positive regulation of ryanodine-sensitive calcium-release channel activity,cellular response to arsenic-containing substance,cellular oxidant detoxification,glutathione derivative biosynthetic processglutathione transferase activity,protein binding,oxidoreductase activity,glutathione dehydrogenase (ascorbate) activity,methylarsonate reductase activityc>sp|P78417|GSTO1_HUMAN Glutathione S-transferase omega-1 OS=Homo sapiens OX=9606 GN=GSTO1 PE=1 SV=2Q92692NECTIN2 NECT2_HUMANNectin-2acrosome assembly,positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target,positive regulation of immunoglobulin mediated immune response,cytoskeleton organization,homophilic cell adhesion via plasma membrane adhesion molecules,heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules,signal transduction,spermatid development,spermatid nucleus differentiation,cell recognition,fertilization,fusion of virus membrane with host plasma membrane,sperm mitochondrion organization,cell part morphogenesis,positive regulation of mast cell activation,adherens junction organization,susceptibility to natural killer cell mediated cytotoxicity,adhesion of symbiont to host,cilium organization,positive regulation of natural killer cell mediated cytotoxicity,regulation of viral entry into host cell,coreceptor-mediated virion attachment to host cell,regulation of immune response,establishment of mitochondrion localization,susceptibility to T cell mediated cytotoxicityvirus receptor activity,receptor binding,protein binding,coreceptor activity,identical protein binding,protein homodimerization activity,protein heterodimerization activity,cell adhesion molecule bindingplasma membrane,integral component of plasma membrane,cell-cell junction,cell-cell adherens junction,zonula adherens,focal adhesion,cell surface,integral component of membrane,cell-cell contact zone,extracellular exosomeL>sp|Q92692|NECT2_HUMAN Nectin-2 OS=Homo sapiens OX=9606 GN=NECTIN2 PE=1 SV=1Q15836VAMP3 VAMP3_HUMAN%Vesicle-associated membrane protein 3spositive regulation of receptor recycling,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent,protein complex assembly,exocytosis,vesicle docking involved in exocytosis,vesicle fusion,vesicle-mediated transport,calcium ion regulated exocytosis,substrate adhesion-dependent cell spreading,SNARE complex assembly,retrograde transport, endosome to Golgi,Golgi to plasma membrane protein transport,membrane organization,membrane fusion,negative regulation of secretion by cell,positive regulation of immunoglobulin secretion,mucus secretion,regulation of histamine secretion by mast cellGSNARE binding,SNAP receptor activity,protein binding,syntaxin-1 bindingintracellular,cytosol,plasma membrane,cell surface,integral component of membrane,apical plasma membrane,cell junction,transport vesicle,clathrin-coated vesicle,secretory granule,clathrin-coated vesicle membrane,phagocytic vesicle membrane,SNARE complex,trans-Golgi network membrane,neuron projection,intracellular membrane-bounded organelle,synapse,perinuclear region of cytoplasm,recycling endosome,recycling endosome membraneg>sp|Q15836|VAMP3_HUMAN Vesicle-associated membrane protein 3 OS=Homo sapiens OX=9606 GN=VAMP3 PE=1 SV=3P48735IDH2 IDHP_HUMAN.Isocitrate dehydrogenase [NADP], mitochondrial5carbohydrate metabolic process,glyoxylate cycle,tricarboxylic acid cycle,isocitrate metabolic process,2-oxoglutarate metabolic process,NADP biosynthetic process,negative regulation of glial cell proliferation,negative regulation of glial cell migration,negative regulation of matrix metallopeptidase secretionKmagnesium ion binding,isocitrate dehydrogenase (NADP+) activity,NAD bindinghmitochondrion,mitochondrial inner membrane,mitochondrial matrix,peroxisome,cytosol,extracellular exosomen>sp|P48735|IDHP_HUMAN Isocitrate dehydrogenase [NADP], mitochondrial OS=Homo sapiens OX=9606 GN=IDH2 PE=1 SV=2Q969X5ERGIC1 ERGI1_HUMAN>Endoplasmic reticulum-Golgi intermediate compartment protein 1&ER to Golgi vesicle-mediated transportGolgi membrane,nucleoplasm,endoplasmic reticulum membrane,endoplasmic reticulum-Golgi intermediate compartment,membrane,integral component of membrane,endoplasmic reticulum-Golgi intermediate compartment membrane,intracellular membrane-bounded organelle>sp|Q969X5|ERGI1_HUMAN Endoplasmic reticulum-Golgi intermediate compartment protein 1 OS=Homo sapiens OX=9606 GN=ERGIC1 PE=1 SV=1Q15477SKIV2L SKIV2_HUMANHelicase SKI2Wexonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay,nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay;RNA binding,ATP-dependent RNA helicase activity,ATP bindingnucleus,cytosol,Ski complexQ>sp|Q15477|SKIV2_HUMAN Helicase SKI2W OS=Homo sapiens OX=9606 GN=SKIV2L PE=1 SV=3Q86Y82STX12 STX12_HUMAN Syntaxin-12~autophagosome assembly,intracellular protein transport,vesicle fusion,cholesterol efflux,vesicle docking,protein stabilization4SNARE binding,SNAP receptor activity,protein bindingGolgi membrane,pre-autophagosomal structure,endosome membrane,endomembrane system,integral component of membrane,SNARE complex,vesicle,membrane raft,phagocytic vesicle,extracellular exosome,BLOC-1 complexM>sp|Q86Y82|STX12_HUMAN Syntaxin-12 OS=Homo sapiens OX=9606 GN=STX12 PE=1 SV=1P06753TPM3 TPM3_HUMANTropomyosin alpha-3 chainpmovement of cell or subcellular component,muscle contraction,actin filament organization,muscle filament slidingZmolecular_function,protein binding,structural constituent of muscle,actin filament bindingzstress fiber,cytosol,cytoskeleton,muscle thin filament tropomyosin,actin filament,actin cytoskeleton,extracellu< lar exosomeY>sp|P06753|TPM3_HUMAN Tropomyosin alpha-3 chain OS=Homo sapiens OX=9606 GN=TPM3 PE=1 SV=2O95340PAPSS2 PAPS2_HUMAN=Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2sulfate assimilation,skeletal system development,blood coagulation,phosphorylation,3'-phosphoadenosine 5'-phosphosulfate biosynthetic process,bone developmentvadenylylsulfate kinase activity,sulfate adenylyltransferase (ATP) activity,ATP binding,nucleotidyltransferase activity>sp|O95340|PAPS2_HUMAN Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 OS=Homo sapiens OX=9606 GN=PAPSS2 PE=1 SV=2O00410IPO5 IPO5_HUMAN Importin-5 protein import into nucleus, translocation,NLS-bearing protein import into nucleus,ribosomal protein import into nucleus,viral process,negative regulation of GTPase activity,positive regulation of protein import into nucleus,cellular response to amino acid stimulusRNA binding,GTPase inhibitor activity,protein binding,nuclear localization sequence binding,Ran GTPase binding,protein transporter activityTnucleus,nuclear pore,nucleolus,cytoplasm,membrane,nuclear membrane,nuclear peripheryJ>sp|O00410|IPO5_HUMAN Importin-5 OS=Homo sapiens OX=9606 GN=IPO5 PE=1 SV=4Q92783STAM STAM1_HUMAN%Signal transducing adapter molecule 1nintracellular protein transport,signal transduction,positive regulation of signal transduction,endosomal transport,macroautophagy,protein deubiquitination,multivesicular body assembly,negative regulation of epidermal growth factor receptor signaling pathway,membrane organization,positive regulation of exosomal secretion,regulation of extracellular exosome assembly(SH3/SH2 adaptor activity,protein binding/cytosol,early endosome membrane,ESCRT-0 complexf>sp|Q92783|STAM1_HUMAN Signal transducing adapter molecule 1 OS=Homo sapiens OX=9606 GN=STAM PE=1 SV=3P62081RPS7 RS7_HUMAN40S ribosomal protein S7nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,neural tube closure,rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,viral transcription,cell differentiation,ribosomal small subunit biogenesisRRNA binding,structural constituent of ribosome,protein binding,poly(U) RNA bindingnucleus,nucleoplasm,nucleolus,microtubule organizing center,cytosol,ribosome,focal adhesion,membrane,cytosolic small ribosomal subunit,intracellular ribonucleoprotein complex,extracellular matrix,extracellular exosomeW>sp|P62081|RS7_HUMAN 40S ribosomal protein S7 OS=Homo sapiens OX=9606 GN=RPS7 PE=1 SV=1P52306RAP1GDS1 GDS1_HUMAN)Rap1 GTPase-GDP dissociation stimulator 1vascular smooth muscle contraction,myosin filament assembly,negative regulation of endoplasmic reticulum calcium ion concentration,positive regulation of GTPase activity,positive regulation of mitochondrial calcium ion concentration)GTPase activator activity,protein bindingAmitochondrion,endoplasmic reticulum,cytosol,extracellular exosomem>sp|P52306|GDS1_HUMAN Rap1 GTPase-GDP dissociation stimulator 1 OS=Homo sapiens OX=9606 GN=RAP1GDS1 PE=1 SV=3P08727KRT19 K1C19_HUMANKeratin, type I cytoskeletal 19Notch signaling pathway,viral process,keratinization,response to estrogen,sarcomere organization,cell differentiation involved in embryonic placenta development,cornificationostructural constituent of cytoskeleton,protein binding,structural constituent of muscle,protein complex bindingcytosol,intermediate filament,plasma membrane,dystrophin-associated glycoprotein complex,apicolateral plasma membrane,Z disc,sarcolemma,costamere,extracellular exosome,cell periphery,terminal weba>sp|P08727|K1C19_HUMAN Keratin, type I cytoskeletal 19 OS=Homo sapiens OX=9606 GN=KRT19 PE=1 SV=4P28799GRN GRN_HUMAN Progranulin,signal transduction,neutrophil degranulationDRNA binding,cytokine activity,protein binding,growth factor activity~extracellular region,extracellular space,lysosome,endosome,endoplasmic reticulum,azurophil granule lumen,extracellular exosomeI>sp|P28799|GRN_HUMAN Progranulin OS=Homo sapiens OX=9606 GN=GRN PE=1 SV=2P36957DLST ODO2_HUMANpDihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrialgeneration of precursor metabolites and energy,tricarboxylic acid cycle,lysine catabolic process,L-lysine catabolic process to acetyl-CoA via saccharopine,glyoxylate metabolic process8dihydrolipoyllysine-residue succinyltransferase activitylnucleus,mitochondrial matrix,membrane,myelin sheath,oxoglutarate dehydrogenase complex,extracellular exosome>sp|P36957|ODO2_HUMAN Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DLST PE=1 SV=4P51148RAB5C RAB5C_HUMANRas-related protein Rab-5Csmall GTPase mediated signal transduction,protein transport,regulation of endocytosis,neutrophil degranulation,plasma membrane to endosome transport,membrane organizationlysosomal membrane,early endosome,lipid particle,plasma membrane,endocytic vesicle,early endosome membrane,azurophil granule membrane,melanosome,extracellular exosome\>sp|P51148|RAB5C_HUMAN Ras-related protein Rab-5C OS=Homo sapiens OX=9606 GN=RAB5C PE=1 SV=2P51798CLCN7 CLCN7_HUMAN!H(+)/Cl(-) exchange transporter 7transport,response to pH,ion transmembrane transport,chloride transmembrane transport,regulation of anion transmembrane transportavoltage-gated chloride channel activity,chloride channel activity,ATP binding,antiporter activityNlysosomal membrane,membrane,integral component of membrane,cytoplasmic vesiclec>sp|P51798|CLCN7_HUMAN H(+)/Cl(-) exchange transporter 7 OS=Homo sapiens OX=9606 GN=CLCN7 PE=1 SV=2P52272HNRNPM HNRPM_HUMAN)Heterogeneous nuclear ribonucleoprotein Malternative mRNA splicing, via spliceosome,mRNA splicing, via spliceosome,fibroblast growth factor receptor signaling pathway,gene expressionNnucleotide binding,RNA binding,protein binding,protein domain specific bindingnucleoplasm,spliceosomal complex,nucleolus,integral component of plasma membrane,membrane,nuclear matrix,extracellular matrix,paraspeckles,extracellular exosome,catalytic step 2 spliceosomel>sp|P52272|HNRPM_HUMAN Heterogeneous nuclear ribonucleoprotein M OS=Homo sapiens OX=9606 GN=HNRNPM PE=1 SV=3Q9Y3B3TMED7 TMED7_HUMAN/Transmembrane emp24 domain-containing protein 7kER to Golgi vesicle-mediated transport,retrograde vesicle-mediated transport, Golgi to ER,protein transport2Golgi membrane,endoplasmic reticulum,endoplasmic reticulum membrane,endoplasmic reticulum-Golgi intermediate compartment,Golgi apparatus,integral component of membrane,COPI vesicle coat,COPII vesicle coat,transport vesicle,endoplasmic reticulum-Golgi intermediate compartment membrane,extracellular exosomeq>sp|Q9Y3B3|TMED7_HUMAN Transmembrane emp24 domain-containing protein 7 OS=Homo sapiens OX=9606 GN=TMED7 PE=1 SV=2P23246SFPQ SFPQ_HUMAN,Splicing factor, proline- and glutamine-richRnegative regulation of transcription from RNA polymerase II promoter,alternative mRNA splicing, via spliceosome,double-strand break repair via homologous recombination,transcription, DNA-templated,mRNA processing,RNA splicing,regulation of circadian rhythm,negative regulation of circadian rhythm,positive regulation of sister chromatid cohesion,negative regulation of transcription, DNA-templated,positive regulation of transcription from RNA polymerase II promoter,rhythmic process,histone H3 deacetylation,positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathwayJnucleotide binding,transcription regulatory region sequence-specific DNA binding,RNA polymerase II distal enhancer sequence-specific DNA binding,core promoter binding,DNA binding,chromatin binding,RNA binding,protein binding,protein homodimerization activity,histone deacetylase binding,transcription regulatory region DNA bindingchromatin,nucleus,nucleoplasm,cytoplasm,nuclear matrix,nuclear speck,extracellular matrix,paraspeckles,RNA polymerase II transcription factor complexl>sp|P23246|SFPQ_HUMAN Splicing facto< r, proline- and glutamine-rich OS=Homo sapiens OX=9606 GN=SFPQ PE=1 SV=2Q9ULA0DNPEP DNPEP_HUMANAspartyl aminopeptidase%proteolysis,peptide metabolic processqaminopeptidase activity,protein binding,zinc ion binding,identical protein binding,metalloaminopeptidase activity-nucleus,cytoplasm,cytosol,blood microparticleY>sp|Q9ULA0|DNPEP_HUMAN Aspartyl aminopeptidase OS=Homo sapiens OX=9606 GN=DNPEP PE=1 SV=2Q9H223EHD4 EHD4_HUMANEH domain-containing protein 4pinocytosis,regulation of endocytosis,endocytic recycling,positive regulation of peptidyl-tyrosine phosphorylation,protein homooligomerization,cellular response to growth factor stimulusanucleic acid binding,calcium ion binding,protein binding,ATP binding,GTP binding,cadherin bindingnucleus,endoplasmic reticulum,plasma membrane,membrane,early endosome membrane,perinuclear region of cytoplasm,recycling endosome membrane,extracellular exosome^>sp|Q9H223|EHD4_HUMAN EH domain-containing protein 4 OS=Homo sapiens OX=9606 GN=EHD4 PE=1 SV=1O94874UFL1 UFL1_HUMANE3 UFM1-protein ligase 1'osteoblast differentiation,positive regulation of cell proliferation,negative regulation of protein ubiquitination,negative regulation of NF-kappaB transcription factor activity,regulation of proteasomal ubiquitin-dependent protein catabolic process,regulation of protein localization,regulation of intracellular estrogen receptor signaling pathway,response to endoplasmic reticulum stress,negative regulation of apoptotic process,positive regulation of glial cell proliferation,protein ufmylation,response to L-glutamate,protein K69-linked ufmylation9protein binding,ligase activity,UFM1 transferase activityqcytoplasm,endoplasmic reticulum,endoplasmic reticulum membrane,cytosol,membrane,neuron projection,protein complexX>sp|O94874|UFL1_HUMAN E3 UFM1-protein ligase 1 OS=Homo sapiens OX=9606 GN=UFL1 PE=1 SV=2Q12768WASHC5 WASC5_HUMANWASH complex subunit 5oocyte maturation,protein transport,endosomal transport,polar body extrusion after meiotic divisions,spindle assembly involved in meiosis9early endosome,endoplasmic reticulum,cytosol,WASH complexY>sp|Q12768|WASC5_HUMAN WASH complex subunit 5 OS=Homo sapiens OX=9606 GN=WASHC5 PE=1 SV=1O95747OXSR1 OXSR1_HUMAN$Serine/threonine-protein kinase OSR1Sprotein phosphorylation,response to oxidative stress,peptidyl-threonine phosphorylation,signal transduction by protein phosphorylation,intracellular signal transduction,cellular hypotonic response,negative regulation of potassium ion transmembrane transporter activity,negative regulation of rubidium ion transmembrane transporter activitymagnesium ion binding,protein serine/threonine kinase activity,receptor signaling protein serine/threonine kinase activity,protein binding,ATP bindingf>sp|O95747|OXSR1_HUMAN Serine/threonine-protein kinase OSR1 OS=Homo sapiens OX=9606 GN=OXSR1 PE=1 SV=1Q14103HNRNPD HNRPD_HUMAN*Heterogeneous nuclear ribonucleoprotein D0.mRNA splicing, via spliceosome,telomere maintenance,liver development,transcription, DNA-templated,regulation of transcription, DNA-templated,RNA processing,RNA catabolic process,gene expression,cerebellum development,response to drug,regulation of circadian rhythm,regulation of mRNA stability,positive regulation of translation,positive regulation of transcription, DNA-templated,mRNA stabilization,response to calcium ion,response to electrical stimulus,3'-UTR-mediated mRNA destabilization,cellular response to amino acid stimulus,cellular response to estradiol stimulus,cellular response to nitric oxide,circadian regulation of translation,response to rapamycin,positive regulation of telomere capping,response to sodium phosphate,cellular response to putrescine,Requires Ontology,hepatocyte dedifferentiationnucleotide binding,AT DNA binding,chromatin binding,RNA binding,protein binding,transcription factor binding,mRNA 3'-UTR AU-rich region binding,telomeric DNA binding,histone deacetylase bindingYnucleus,nucleoplasm,cytosol,intracellular ribonucleoprotein complex,extracellular exosomem>sp|Q14103|HNRPD_HUMAN Heterogeneous nuclear ribonucleoprotein D0 OS=Homo sapiens OX=9606 GN=HNRNPD PE=1 SV=1P04062GBA GLCM_HUMAN!Lysosomal acid glucosylceramidaseycarbohydrate metabolic process,glucosylceramide catabolic process,glycosphingolipid metabolic process,cellular response to starvation,response to pH,regulation of macroautophagy,termination of signal transduction,regulation of cellular protein metabolic process,positive regulation of proteasomal ubiquitin-dependent protein catabolic process,negative regulation of protein homooligomerization,negative regulation of interleukin-6 production,regulation of water loss via skin,response to testosterone,positive regulation of protein dephosphorylation,positive regulation of protein complex disassembly,negative regulation of MAP kinase activity,skin morphogenesis,response to estrogen,sphingosine biosynthetic process,ceramide biosynthetic process,negative regulation of inflammatory response,positive regulation of protein metabolic process,response to glucocorticoid,cellular response to tumor necrosis factor,response to thyroid hormone,negative regulation of neuron death,positive regulation of proteolysis involved in cellular protein catabolic process,positive regulation of protein lipidation,positive regulation of neuronal action potential,positive regulation of mitophagy in response to mitochondrial depolarization,autophagosome organization,regulation of lysosomal protein catabolic process,mitochondrion organization,neuron projection development,cell death in response to oxidative stress<glucosylceramidase activity,receptor binding,protein bindingLextracellular space,lysosomal membrane,lysosomal lumen,extracellular exosome`>sp|P04062|GLCM_HUMAN Lysosomal acid glucosylceramidase OS=Homo sapiens OX=9606 GN=GBA PE=1 SV=3Q15435PPP1R7 PP1R7_HUMAN*Protein phosphatase 1 regulatory subunit 7{chromosome segregation,biological_process,positive regulation of protein dephosphorylation,regulation of catalytic activityPprotein binding,protein phosphatase regulator activity,enzyme regulator activity2nucleus,chromosome,cytoplasm,extracellular exosomem>sp|Q15435|PP1R7_HUMAN Protein phosphatase 1 regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PPP1R7 PE=1 SV=1P14866HNRNPL HNRPL_HUMAN)Heterogeneous nuclear ribonucleoprotein LCregulation of alternative mRNA splicing, via spliceosome,mRNA splicing, via spliceosome,RNA processing,circadian rhythm,gene expression,cellular response to amino acid starvation,positive regulation of translation,negative regulation of mRNA splicing, via spliceosome,response to peptide,positive regulation of mRNA bindingnucleotide binding,RNA binding,mRNA 3'-UTR binding,protein binding,transcription regulatory region DNA binding,pre-mRNA intronic binding,mRNA CDS bindingnucleus,nucleoplasm,cytosol,membrane,intracellular ribonucleoprotein complex,ribonucleoprotein granule,pronucleus,perinuclear region of cytoplasm,extracellular exosomel>sp|P14866|HNRPL_HUMAN Heterogeneous nuclear ribonucleoprotein L OS=Homo sapiens OX=9606 GN=HNRNPL PE=1 SV=2P55263ADK ADK_HUMANAdenosine kinaseadenosine salvage,dATP biosynthetic process,ribonucleoside monophosphate biosynthetic process,purine-containing compound salvage,AMP salvage,carbohydrate phosphorylation`RNA binding,adenosine kinase activity,ATP binding,metal ion binding,carbohydrate kinase activitynucleus,nucleoplasm,cytosolN>sp|P55263|ADK_HUMAN Adenosine kinase OS=Homo sapiens OX=9606 GN=ADK PE=1 SV=2P46782RPS5 RS5_HUMAN40S ribosomal protein S5nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,rRNA processing,translation,translational initiation,regulation of translational fidelity,SRP-dependent cotranslational protein targeting to membrane,viral transcriptionKRNA binding,mRNA binding,structural constituent of ribosome,protein bindingnucleoplasm,cytosol,focal adhesion,membrane,cytosolic small ribosomal subunit,intracellular ribonucleoprotein complex,extracellular matrix,extracellular exosomeW>sp|P46782|RS5_HUMAN 40S riboso< mal protein S5 OS=Homo sapiens OX=9606 GN=RPS5 PE=1 SV=4Q9H3M7TXNIP TXNIP_HUMANThioredoxin-interacting proteinBnegative regulation of transcription from RNA polymerase II promoter,transcription, DNA-templated,protein import into nucleus,cell cycle,response to mechanical stimulus,response to glucose,keratinocyte differentiation,response to estradiol,response to progesterone,regulation of cell proliferation,response to drug,response to hydrogen peroxide,positive regulation of apoptotic process,negative regulation of catalytic activity,platelet-derived growth factor receptor signaling pathway,response to calcium ion,negative regulation of cell division,cellular response to tumor cellJenzyme inhibitor activity,protein binding,ubiquitin protein ligase binding;nucleus,cytoplasm,mitochondrial intermembrane space,cytosola>sp|Q9H3M7|TXNIP_HUMAN Thioredoxin-interacting protein OS=Homo sapiens OX=9606 GN=TXNIP PE=1 SV=1P55058PLTP PLTP_HUMANPhospholipid transfer proteinlipid metabolic process,lipid transport,vitamin E biosynthetic process,positive regulation of cholesterol efflux,flagellated sperm motility,high-density lipoprotein particle remodeling lipid binding(extracellular region,extracellular space]>sp|P55058|PLTP_HUMAN Phospholipid transfer protein OS=Homo sapiens OX=9606 GN=PLTP PE=1 SV=1P31431SDC4 SDC4_HUMAN Syndecan-4Sretinoid metabolic process,ureteric bud development,neural tube closure,glycosaminoglycan biosynthetic process,glycosaminoglycan catabolic process,signal transduction,regulation of fibroblast migration,glycosaminoglycan metabolic process,wound healing,negative regulation of T cell proliferation,positive regulation of protein kinase activity,leukocyte migration,positive regulation of stress fiber assembly,positive regulation of focal adhesion assembly,inner ear receptor stereocilium organization,positive regulation of exosomal secretion,positive regulation of extracellular exosome assembly]fibronectin binding,protein kinase C binding,protein binding,thrombospondin receptor activityGolgi lumen,plasma membrane,integral component of plasma membrane,focal adhesion,cell surface,costamere,lysosomal lumen,membrane raft,extracellular exosomeJ>sp|P31431|SDC4_HUMAN Syndecan-4 OS=Homo sapiens OX=9606 GN=SDC4 PE=1 SV=2Q07020RPL18 RL18_HUMAN60S ribosomal protein L18inucleus,nucleolus,endoplasmic reticulum,cytosol,focal adhesion,membrane,cytosolic large ribosomal subunitZ>sp|Q07020|RL18_HUMAN 60S ribosomal protein L18 OS=Homo sapiens OX=9606 GN=RPL18 PE=1 SV=2Q06828FMOD FMOD_HUMAN Fibromodulintransforming growth factor beta receptor complex assembly,keratan sulfate biosynthetic process,collagen fibril organization,keratan sulfate catabolic process,axonogenesis|extracellular region,proteinaceous extracellular matrix,extracellular space,Golgi lumen,lysosomal lumen,extracellular matrixL>sp|Q06828|FMOD_HUMAN Fibromodulin OS=Homo sapiens OX=9606 GN=FMOD PE=1 SV=2P63241EIF5A IF5A1_HUMAN-Eukaryotic translation initiation factor 5A-1;mRNA export from nucleus,translational frameshifting,protein export from nucleus,nucleocytoplasmic transport,apoptotic process,positive regulation of cell proliferation,peptidyl-lysine modification to peptidyl-hypusine,positive regulation of translational elongation,positive regulation of translational terminationRNA binding,translation elongation factor activity,protein binding,U6 snRNA binding,ribosome binding,protein N-terminus bindingvnucleus,annulate lamellae,nuclear pore,cytoplasm,endoplasmic reticulum membrane,cytosol,membrane,extracellular exosomeo>sp|P63241|IF5A1_HUMAN Eukaryotic translation initiation factor 5A-1 OS=Homo sapiens OX=9606 GN=EIF5A PE=1 SV=2P68366TUBA4A TBA4A_HUMANTubulin alpha-4A chainG2/M transition of mitotic cell cycle,platelet degranulation,cytoskeleton organization,microtubule-based process,ciliary basal body dockingaGTPase activity,structural constituent of cytoskeleton,protein binding,GTP binding,enzyme bindingWextracellular region,cytosol,microtubule,microtubule cytoskeleton,extracellular exosomeY>sp|P68366|TBA4A_HUMAN Tubulin alpha-4A chain OS=Homo sapiens OX=9606 GN=TUBA4A PE=1 SV=1Q6V0I7FAT4 FAT4_HUMANProtocadherin Fat 4Vbranching involved in ureteric bud morphogenesis,heart morphogenesis,plasma membrane organization,homophilic cell adhesion via plasma membrane adhesion molecules,heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules,Notch signaling pathway,fibroblast growth factor receptor signaling pathway,cerebral cortex development,neurogenesis,hippo signaling,ossification involved in bone maturation,digestive tract development,inner ear receptor stereocilium organization,condensed mesenchymal cell proliferation,regulation of metanephric nephron tubule epithelial cell differentiationfintracellular,plasma membrane,integral component of membrane,apical part of cell,extracellular exosomeS>sp|Q6V0I7|FAT4_HUMAN Protocadherin Fat 4 OS=Homo sapiens OX=9606 GN=FAT4 PE=1 SV=2P46777RPL5 RL5_HUMAN60S ribosomal protein L5 ribosomal large subunit assembly,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,viral transcription,ribosomal large subunit biogenesisNRNA binding,structural constituent of ribosome,protein binding,5S rRNA bindingnucleus,nucleolus,cytoplasm,cytosol,focal adhesion,membrane,cytosolic large ribosomal subunit,intracellular ribonucleoprotein complex,extracellular exosomeW>sp|P46777|RL5_HUMAN 60S ribosomal protein L5 OS=Homo sapiens OX=9606 GN=RPL5 PE=1 SV=3O43294TGFB1I1 TGFI1_HUMAN>Transforming growth factor beta-1-induced transcript 1 proteintranscription from RNA polymerase II promoter,cell adhesion,negative regulation of cell proliferation,response to heat,positive regulation of epithelial to mesenchymal transition,Wnt signaling pathway,morphogenesis of embryonic epithelium,positive regulation of transforming growth factor beta receptor signaling pathway,negative regulation of transforming growth factor beta receptor signaling pathway,androgen receptor signaling pathway,ubiquitin-dependent SMAD protein catabolic process,epithelial cell differentiation,cell fate commitment,negative regulation of fat cell differentiation,positive regulation of transcription, DNA-templatedtranscription coactivator activity,protein binding,zinc ion binding,Roundabout binding,androgen receptor binding,I-SMAD bindingWintracellular,cytoplasm,cytoskeleton,focal adhesion,nuclear matrix,extracellular matrix>sp|O43294|TGFI1_HUMAN Transforming growth factor beta-1-induced transcript 1 protein OS=Homo sapiens OX=9606 GN=TGFB1I1 PE=1 SV=2Q12765SCRN1 SCRN1_HUMAN Secernin-1proteolysis,exocytosis7molecular_function,protein binding,dipeptidase activity"nucleus,cytoplasm,nuclear membraneL>sp|Q12765|SCRN1_HUMAN Secernin-1 OS=Homo sapiens OX=9606 GN=SCRN1 PE=1 SV=2Q9Y3U8RPL36 RL36_HUMAN60S ribosomal protein L36nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,cytoplasmic translation,rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,viral transcriptionFnucleolus,cytoplasm,cytosol,membrane,cytosolic large ribosomal subunitZ>sp|Q9Y3U8|RL36_HUMAN 60S ribosomal protein L36 OS=Homo sapiens OX=9606 GN=RPL36 PE=1 SV=3P46779RPL28 RL28_HUMAN60S ribosomal protein L28nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,viral transcription,regulation of mitophagy,positive regulation of protein targeting to mitochondrioncytosol,membrane,cytosolic large ribosomal subunit,dendrite,cytoplasmic ribonucleoprotein granule,cell body,extracellular exosomeZ>sp|P46779|RL28_HUMAN 60S ribosomal protein L28 OS=Homo sapiens OX=9606 GN=RPL28 PE=1 SV=3P78539SRPX SRPX_HUMAN$Sushi repeat-containing protein SRPXphagolysosome assembly,autophagy,cell adhesion,response < to endoplasmic reticulum stress,negative regulation of cell proliferation involved in contact inhibition,positive regulation of extrinsic apoptotic signaling pathway in absence of ligand9autophagosome,endoplasmic reticulum,cell surface,membraned>sp|P78539|SRPX_HUMAN Sushi repeat-containing protein SRPX OS=Homo sapiens OX=9606 GN=SRPX PE=1 SV=1P01033TIMP1 TIMP1_HUMANMetalloproteinase inhibitor 15cell activation,platelet degranulation,aging,positive regulation of cell proliferation,response to hormone,negative regulation of endopeptidase activity,extracellular matrix disassembly,response to cytokine,wound healing,negative regulation of apoptotic process,negative regulation of catalytic activity,response to peptide hormone,negative regulation of membrane protein ectodomain proteolysis,cartilage development,negative regulation of trophoblast cell migration,negative regulation of metallopeptidase activity,regulation of integrin-mediated signaling pathwayprotease binding,cytokine activity,protein binding,growth factor activity,metalloendopeptidase inhibitor activity,metal ion bindingextracellular region,proteinaceous extracellular matrix,basement membrane,extracellular space,platelet alpha granule lumen,extracellular exosome_>sp|P01033|TIMP1_HUMAN Metalloproteinase inhibitor 1 OS=Homo sapiens OX=9606 GN=TIMP1 PE=1 SV=1P13798APEH ACPH_HUMANAcylamino-acid-releasing enzyme]translational termination,proteolysis,neutrophil degranulation,beta-amyloid metabolic processqRNA binding,serine-type endopeptidase activity,protein binding,omega peptidase activity,identical protein binding`extracellular region,cytosol,nuclear membrane,extracellular exosome,ficolin-1-rich granule lumen_>sp|P13798|ACPH_HUMAN Acylamino-acid-releasing enzyme OS=Homo sapiens OX=9606 GN=APEH PE=1 SV=4P21291CSRP1 CSRP1_HUMAN#Cysteine and glycine-rich protein 1platelet aggregationRNA binding,zinc ion binding,nucleus,focal adhesion,extracellular exosomee>sp|P21291|CSRP1_HUMAN Cysteine and glycine-rich protein 1 OS=Homo sapiens OX=9606 GN=CSRP1 PE=1 SV=3Q16222UAP1 UAP1_HUMAN(UDP-N-acetylhexosamine pyrophosphorylase,UDP-N-acetylglucosamine biosynthetic process_UDP-N-acetylglucosamine diphosphorylase activity,carbohydrate binding,identical protein binding#nucleoplasm,cytosol,plasma membraneh>sp|Q16222|UAP1_HUMAN UDP-N-acetylhexosamine pyrophosphorylase OS=Homo sapiens OX=9606 GN=UAP1 PE=1 SV=3P08237PFKM PFKAM_HUMAN0ATP-dependent 6-phosphofructokinase, muscle type?glycogen catabolic process,fructose 6-phosphate metabolic process,glycolytic process,positive regulation of insulin secretion,glucose homeostasis,muscle cell cellular homeostasis,carbohydrate phosphorylation,protein oligomerization,canonical glycolysis,glycolysis from storage polysaccharide through glucose-1-phosphate6-phosphofructokinase activity,protein binding,ATP binding,protein C-terminus binding,kinase binding,identical protein binding,protein homodimerization activity,metal ion binding,fructose bindinghcytosol,6-phosphofructokinase complex,apical plasma membrane,extracellular exosome,sperm principal pieceq>sp|P08237|PFKAM_HUMAN ATP-dependent 6-phosphofructokinase, muscle type OS=Homo sapiens OX=9606 GN=PFKM PE=1 SV=2P28300LOX LYOX_HUMANProtein-lysine 6-oxidase"cellular protein modification process,heart development,extracellular matrix organization,collagen fibril organization,lung development,aorta development,wound healing,response to drug,elastic fiber assembly,blood vessel morphogenesis,response to steroid hormone,oxidation-reduction processDprotein-lysine 6-oxidase activity,copper ion binding,protein bindingcextracellular region,proteinaceous extracellular matrix,collagen trimer,extracellular space,nucleusW>sp|P28300|LYOX_HUMAN Protein-lysine 6-oxidase OS=Homo sapiens OX=9606 GN=LOX PE=1 SV=2P02771AFP FETA_HUMANAlpha-fetoproteiniovulation from ovarian follicle,transport,progesterone metabolic process,SMAD protein signal transduction!protein binding,metal ion bindingextracellular space,cytosolP>sp|P02771|FETA_HUMAN Alpha-fetoprotein OS=Homo sapiens OX=9606 GN=AFP PE=1 SV=1P55290CDH13 CAD13_HUMAN Cadherin-13mitotic cell cycle,positive regulation of endothelial cell proliferation,positive regulation of cell-matrix adhesion,sprouting angiogenesis,homophilic cell adhesion via plasma membrane adhesion molecules,negative regulation of cell adhesion,Rho protein signal transduction,negative regulation of cell proliferation,calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules,Rac protein signal transduction,lamellipodium assembly,regulation of endocytosis,positive regulation of cell migration,adherens junction organization,regulation of epidermal growth factor receptor signaling pathway,endothelial cell migration,keratinocyte proliferation,positive regulation of transcription from RNA polymerase II promoter,positive regulation of smooth muscle cell proliferation,positive regulation of calcium-mediated signaling,positive regulation of positive chemotaxis,localization within membrane,low-density lipoprotein particle mediated signalingcalcium ion binding,low-density lipoprotein particle binding,protein homodimerization activity,cadherin binding,adiponectin binding,lipoprotein particle bindingextracellular space,cytoplasm,plasma membrane,caveola,focal adhesion,external side of plasma membrane,anchored component of membrane,neuron projection,perinuclear region of cytoplasm,extracellular exosomeM>sp|P55290|CAD13_HUMAN Cadherin-13 OS=Homo sapiens OX=9606 GN=CDH13 PE=1 SV=1O00264PGRMC1 PGRC1_HUMAN5Membrane-associated progesterone receptor component 1,steroid binding,protein binding,heme bindingendoplasmic reticulum membrane,plasma membrane,endomembrane system,membrane,integral component of membrane,specific granule membrane,extracellular exosomex>sp|O00264|PGRC1_HUMAN Membrane-associated progesterone receptor component 1 OS=Homo sapiens OX=9606 GN=PGRMC1 PE=1 SV=3P20774OGN MIME_HUMANMimecanaxonogenesis,keratan sulfate biosynthetic process,keratan sulfate catabolic process,negative regulation of smooth muscle cell proliferation&protein binding,growth factor activityextracellular region,proteinaceous extracellular matrix,extracellular space,Golgi lumen,lysosomal lumen,extracellular exosome,extracellular vesicle,extracellular matrixF>sp|P20774|MIME_HUMAN Mimecan OS=Homo sapiens OX=9606 GN=OGN PE=1 SV=1P49748ACADVL ACADV_HUMAN>Very long-chain specific acyl-CoA dehydrogenase, mitochondrialtemperature homeostasis,fatty acid beta-oxidation,response to cold,energy derivation by oxidation of organic compounds,epithelial cell differentiation,fatty acid beta-oxidation using acyl-CoA dehydrogenase,IRE1-mediated unfolded protein response,negative regulation of fatty acid biosynthetic process,negative regulation of fatty acid oxidation,regulation of cholesterol metabolic processnacyl-CoA dehydrogenase activity,long-chain-acyl-CoA dehydrogenase activity,flavin adenine dinucleotide bindingpnucleus,nucleolus,mitochondrion,mitochondrial inner membrane,mitochondrial matrix,cytosol,mitochondrial nucleoid>sp|P49748|ACADV_HUMAN Very long-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADVL PE=1 SV=1Q99685MGLL MGLL_HUMANMonoglyceride lipaseplipid metabolic process,fatty acid biosynthetic process,inflammatory response,regulation of signal transduction,arachidonic acid metabolic process,triglyceride catabolic process,acylglycerol acyl-chain remodeling,acylglycerol catabolic process,regulation of inflammatory response,regulation of sensory perception of pain,regulation of endocannabinoid signaling pathwayYlysophospholipase activity,protein homodimerization activity,acylglycerol lipase activityknucleoplasm,endoplasmic reticulum membrane,cytosol,plasma membrane,membrane,extrinsic component of membraneT>sp|Q99685|MGLL_HUMAN Monoglyceride lipase OS=Homo sapiens OX=9606 GN=MGLL PE=1 SV=2P83731RPL24 RL24_HUMAN60S ribosomal protein L24ribosomal large subunit assembly,nuclear-transcribed m< RNA catabolic process, nonsense-mediated decay,rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,mitotic cell cycle checkpoint,exit from mitosis,viral transcription,optic nerve development,retinal ganglion cell axon guidance,retina development in camera-type eye,assembly of large subunit precursor of preribosomeRcytoplasm,cytosol,membrane,cytosolic large ribosomal subunit,extracellular exosomeZ>sp|P83731|RL24_HUMAN 60S ribosomal protein L24 OS=Homo sapiens OX=9606 GN=RPL24 PE=1 SV=1P63173RPL38 RL38_HUMAN60S ribosomal protein L38tnuclear-transcribed mRNA catabolic process, nonsense-mediated decay,skeletal system development,ossification,rRNA processing,translation,translational initiation,regulation of translation,SRP-dependent cotranslational protein targeting to membrane,sensory perception of sound,viral transcription,90S preribosome assembly,middle ear morphogenesis,axial mesoderm developmentZcytosol,focal adhesion,cytosolic large ribosomal subunit,eukaryotic 80S initiation complexZ>sp|P63173|RL38_HUMAN 60S ribosomal protein L38 OS=Homo sapiens OX=9606 GN=RPL38 PE=1 SV=2Q9Y6G9DYNC1LI1 DC1L1_HUMAN/Cytoplasmic dynein 1 light intermediate chain 1Mmicrotubule cytoskeleton organization,ER to Golgi vesicle-mediated transport,microtubule-based movement,mitotic nuclear division,viral process,antigen processing and presentation of exogenous peptide antigen via MHC class II,neutrophil degranulation,cell division,positive regulation of mitotic cell cycle spindle assembly checkpointuRNA binding,microtubule motor activity,protein binding,ATP binding,GDP binding,dynein heavy chain binding,GTP bindingkinetochore,condensed chromosome kinetochore,spindle pole,centrosome,cytosol,cytoplasmic dynein complex,microtubule,plasma membrane,membrane,secretory granule membrane,ficolin-1-rich granule membranet>sp|Q9Y6G9|DC1L1_HUMAN Cytoplasmic dynein 1 light intermediate chain 1 OS=Homo sapiens OX=9606 GN=DYNC1LI1 PE=1 SV=3Q9HBI1PARVB PARVB_HUMAN Beta-parvincell adhesion,cell projection assembly,lamellipodium assembly,actin cytoskeleton reorganization,establishment or maintenance of cell polarity regulating cell shapeactin binding,protein bindingHcytosol,cytoskeleton,plasma membrane,focal adhesion,Z disc,lamellipodiumM>sp|Q9HBI1|PARVB_HUMAN Beta-parvin OS=Homo sapiens OX=9606 GN=PARVB PE=1 SV=1P17844DDX5 DDX5_HUMAN(Probable ATP-dependent RNA helicase DDX5negative regulation of transcription from RNA polymerase II promoter,regulation of alternative mRNA splicing, via spliceosome,mRNA splicing, via spliceosome,nuclear-transcribed mRNA catabolic process,mRNA transcription,RNA secondary structure unwinding,cell growth,positive regulation of intracellular estrogen receptor signaling pathway,positive regulation of DNA damage response, signal transduction by p53 class mediator,regulation of viral genome replication,regulation of osteoblast differentiation,positive regulation of transcription from RNA polymerase II promoter,rhythmic process,regulation of androgen receptor signaling pathway,intrinsic apoptotic signaling pathway by p53 class mediator,regulation of skeletal muscle cell differentiationCtranscription coactivator activity,RNA binding,RNA helicase activity,mRNA 3'-UTR binding,ATP-dependent RNA helicase activity,protein binding,calmodulin binding,ATP binding,enzyme binding,estrogen receptor binding,pre-mRNA binding,ribonucleoprotein complex binding,calcium-dependent protein binding,androgen receptor bindingnucleus,nucleoplasm,nucleolus,membrane,intracellular ribonucleoprotein complex,extracellular matrix,extracellular exosome,catalytic step 2 spliceosomeh>sp|P17844|DDX5_HUMAN Probable ATP-dependent RNA helicase DDX5 OS=Homo sapiens OX=9606 GN=DDX5 PE=1 SV=1P05543SERPINA7 THBG_HUMANThyroxine-binding globulinGnegative regulation of endopeptidase activity,thyroid hormone transport^>sp|P05543|THBG_HUMAN Thyroxine-binding globulin OS=Homo sapiens OX=9606 GN=SERPINA7 PE=1 SV=2P62277RPS13 RS13_HUMAN40S ribosomal protein S13RNA binding,mRNA binding,structural constituent of ribosome,protein binding,small ribosomal subunit rRNA binding,5.8S rRNA bindingnucleus,nucleoplasm,nucleolus,cytosol,ribosome,focal adhesion,membrane,cytosolic small ribosomal subunit,extracellular matrix,extracellular exosomeZ>sp|P62277|RS13_HUMAN 40S ribosomal protein S13 OS=Homo sapiens OX=9606 GN=RPS13 PE=1 SV=2A6NGU5;P19440;P36268GGT3P;GGT1;GGT2 GGT3_HUMAN;GGT1_HUMAN;GGT2_HUMANmPutative glutathione hydrolase 3 proenzyme;Glutathione hydrolase 1 proenzyme;Inactive glutathione hydrolase 2}proteolysis,glutathione metabolic process,glutathione biosynthetic process,glutathione catabolic process,leukotriene biosynthetic process;regulation of immune system process,cellular amino acid metabolic process,glutamate metabolic process,leukotriene metabolic process,glutathione metabolic process,glutathione biosynthetic process,glutathione catabolic process,xenobiotic metabolic process,spermatogenesis,cysteine biosynthetic process,leukotriene biosynthetic process,zymogen activation,regulation of inflammatory response;glutathione metabolic process,glutathione catabolic process,leukotriene biosynthetic process,zymogen activationgamma-glutamyltransferase activity,glutathione hydrolase activity;gamma-glutamyltransferase activity,protein binding,glutathione hydrolase activity;gamma-glutamyltransferase activity,glutathione hydrolase activity~integral component of membrane,anchored component of external side of plasma membrane,extracellular exosome;extracellular space,plasma membrane,integral component of membrane,anchored component of external side of plasma membrane,extracellular exosome;endoplasmic reticulum,anchored component of external side of plasma membrane,perinuclear region of cytoplasm,extracellular exosome5;1;12;2;3.>sp|A6NGU5|GGT3_HUMAN Putative glutathione hydrolase 3 proenzyme OS=Homo sapiens OX=9606 GN=GGT3P PE=5 SV=2;>sp|P19440|GGT1_HUMAN Glutathione hydrolase 1 proenzyme OS=Homo sapiens OX=9606 GN=GGT1 PE=1 SV=2;>sp|P36268|GGT2_HUMAN Inactive glutathione hydrolase 2 OS=Homo sapiens OX=9606 GN=GGT2 PE=1 SV=3Q9P2R3ANKFY1 ANFY1_HUMAN Rabankyrin-5endocytosis,endosome localization,endosomal vesicle fusion,retrograde transport, endosome to Golgi,positive regulation of pinocytosis,Golgi to lysosome transport[protein binding,Rab GTPase binding,metal ion binding,phosphatidylinositol phosphate bindinglysosomal membrane,endosome,early endosome,cytosol,endosome membrane,membrane,intracellular membrane-bounded organelle,macropinosome,extracellular exosome,retromer complexO>sp|Q9P2R3|ANFY1_HUMAN Rabankyrin-5 OS=Homo sapiens OX=9606 GN=ANKFY1 PE=1 SV=2Q92954PRG4 PRG4_HUMANProteoglycan 4@receptor-mediated endocytosis,immune response,cell proliferation2scavenger receptor activity,polysaccharide bindingN>sp|Q92954|PRG4_HUMAN Proteoglycan 4 OS=Homo sapiens OX=9606 GN=PRG4 PE=1 SV=3Q658P3STEAP3 STEA3_HUMANMetalloreductase STEAP3apoptotic process,cell cycle,protein secretion,copper ion import,transferrin transport,regulation of apoptotic process,iron ion homeostasis,oxidation-reduction process,ferric iron import into cellprotein binding,cupric reductase activity,oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor,metal ion binding,ferric-chelate reductase (NADPH) activityUcytoplasm,multivesicular body,integral component of plasma membrane,endosome membraneZ>sp|Q658P3|STEA3_HUMAN Metalloreductase STEAP3 OS=Homo sapiens OX=9606 GN=STEAP3 PE=1 SV=2Q9Y277VDAC3 VDAC3_HUMAN3Voltage-dependent anion-selective channel protein 3anion transport,adenine transport,transmembrane transport,regulation of cilium assembly,regulation of anion transmembrane transportFnucleotide binding,voltage-gated anion channel activity,porin activityUnucleus,mitochondrion,mitochondrial outer membrane,pore complex,extracellular exosomeu>sp|Q9Y277|VDAC3_HUMAN Voltage-dependent anion-selective channel protein 3 OS=Homo sapiens OX=9606 GN=VDAC3 PE=1 SV=1P19623SRM SPEE_HUMANSpermidine < synthase;polyamine metabolic process,spermidine biosynthetic processhspermidine synthase activity,protein binding,identical protein binding,protein homodimerization activityR>sp|P19623|SPEE_HUMAN Spermidine synthase OS=Homo sapiens OX=9606 GN=SRM PE=1 SV=1P05387RPLP2 RLA2_HUMAN60S acidic ribosomal protein P2nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,cytoplasmic translation,rRNA processing,translation,translational initiation,translational elongation,SRP-dependent cotranslational protein targeting to membrane,viral transcription2structural constituent of ribosome,protein binding`>sp|P05387|RLA2_HUMAN 60S acidic ribosomal protein P2 OS=Homo sapiens OX=9606 GN=RPLP2 PE=1 SV=1P41221WNT5A WNT5A_HUMANProtein Wnt-5a activation of MAPK activity,establishment of planar polarity,somitogenesis,epithelial to mesenchymal transition,positive regulation of endothelial cell proliferation,heart looping,positive regulation of mesenchymal cell proliferation,lens development in camera-type eye,positive regulation of cytokine secretion involved in immune response,type B pancreatic cell development,planar cell polarity pathway involved in axis elongation,optic cup formation involved in camera-type eye development,Wnt signaling pathway, calcium modulating pathway,activation of JUN kinase activity,axon guidance,hindgut morphogenesis,midgut development,male gonad development,anterior/posterior axis specification, embryo,response to organic substance,positive regulation of endothelial cell migration,positive regulation of peptidyl-threonine phosphorylation,positive regulation of T cell chemotaxis,positive regulation of neuron projection development,Wnt signaling pathway,olfactory bulb interneuron development,neuron differentiation,keratinocyte differentiation,lung development,negative regulation of BMP signaling pathway,positive regulation of cGMP metabolic process,positive regulation of protein binding,activation of protein kinase B activity,positive regulation of interferon-gamma production,positive regulation of interleukin-6 production,positive regulation of peptidyl-serine phosphorylation,cellular protein localization,non-canonical Wnt signaling pathway,post-anal tail morphogenesis,chemoattraction of serotonergic neuron axon,chemorepulsion of dopaminergic neuron axon,non-canonical Wnt signaling pathway via JNK cascade,negative regulation of fibroblast growth factor receptor signaling pathway,wound healing,embryonic digit morphogenesis,positive regulation of macrophage activation,negative regulation of apoptotic process,positive regulation of chemokine biosynthetic process,cell fate commitment,establishment of epithelial cell apical/basal polarity,negative regulation of fat cell differentiation,positive regulation of protein catabolic process,positive regulation of angiogenesis,positive regulation of ossification,positive regulation of endocytosis,positive regulation of meiotic nuclear division,negative regulation of transcription, DNA-templated,positive regulation of transcription, DNA-templated,positive regulation of transcription from RNA polymerase II promoter,negative regulation of melanin biosynthetic process,positive regulation of fibroblast proliferation,paraxial mesoderm formation,notochord morphogenesis,embryonic skeletal system development,genitalia development,negative regulation of axon extension involved in axon guidance,hypophysis morphogenesis,negative regulation of epithelial cell proliferation,positive regulation of interleukin-1 beta secretion,positive regulation of inflammatory response,positive regulation of NF-kappaB transcription factor activity,cartilage development,negative regulation of synapse assembly,palate development,convergent extension involved in axis elongation,convergent extension involved in organogenesis,uterus development,cervix development,vagina development,canonical Wnt signaling pathway,Wnt signaling pathway, planar cell polarity pathway,urinary bladder development,face development,positive regulation of type I interferon-mediated signaling pathway,lateral sprouting involved in mammary gland duct morphogenesis,mesenchymal-epithelial cell signaling,negative regulation of prostatic bud formation,mammary gland branching involved in thelarche,epithelial cell proliferation involved in mammary gland duct elongation,positive regulation of response to cytokine stimulus,regulation of branching involved in mammary gland duct morphogenesis,planar cell polarity pathway involved in gastrula mediolateral intercalation,mesodermal to mesenchymal transition involved in gastrulation,positive regulation of macrophage cytokine production,membrane organization,positive regulation of cartilage development,planar cell polarity pathway involved in outflow tract morphogenesis,planar cell polarity pathway involved in ventricular septum morphogenesis,planar cell polarity pathway involved in cardiac right atrium morphogenesis,planar cell polarity pathway involved in cardiac muscle tissue morphogenesis,planar cell polarity pathway involved in pericardium morphogenesis,positive regulation of thymocyte apoptotic process,cellular response to lipopolysaccharide,cellular response to calcium ion,cellular response to retinoic acid,cellular response to interferon-gamma,hematopoietic stem cell proliferation,cellular response to transforming growth factor beta stimulus,negative regulation of mesenchymal cell proliferation,primitive streak formation,positive regulation of protein kinase C signaling,negative regulation of canonical Wnt signaling pathway,cochlea morphogenesis,planar cell polarity pathway involved in neural tube closure,activation of GTPase activity,melanocyte proliferation,presynapse assembly,postsynapse assembly,positive regulation of protein kinase C activity,positive regulation of protein localization to synapse,regulation of cellular protein localization,excitatory synapse assembly,inhibitory synapse assembly,negative regulation of cell proliferation in midbrain,planar cell polarity pathway involved in axon guidance,Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation,planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation,positive regulation of cell-cell adhesion mediated by cadherin,positive regulation of non-canonical Wnt signaling pathway,positive regulation of interleukin-8 secretionQtranscription factor activity, sequence-specific DNA binding,frizzled binding,frizzled-2 binding,receptor tyrosine kinase-like orphan receptor binding,cytokine activity,protein binding,protein domain specific binding,transcription regulatory region DNA binding,receptor agonist activity,chemoattractant activity involved in axon guidance extracellular region,proteinaceous extracellular matrix,extracellular space,endoplasmic reticulum lumen,Golgi lumen,plasma membrane,cell surface,clathrin-coated vesicle membrane,endocytic vesicle membrane,clathrin-coated endocytic vesicle membrane,extracellular exosomeP>sp|P41221|WNT5A_HUMAN Protein Wnt-5a OS=Homo sapiens OX=9606 GN=WNT5A PE=1 SV=2P61353RPL27 RL27_HUMAN60S ribosomal protein L27nucleus,cytosol,ribosome,focal adhesion,membrane,cytosolic large ribosomal subunit,intracellular ribonucleoprotein complex,extracellular matrix,extracellular exosomeZ>sp|P61353|RL27_HUMAN 60S ribosomal protein L27 OS=Homo sapiens OX=9606 GN=RPL27 PE=1 SV=2O14908GIPC1 GIPC1_HUMAN#PDZ domain-containing protein GIPC1protein targeting,G-protein coupled receptor signaling pathway,chemical synaptic transmission,glutamate secretion,positive regulation of transforming growth factor beta receptor signaling pathway,regulation of protein stability,negative regulation of proteasomal ubiquitin-dependent protein catabolic process,positive regulation of cytokinesis,endothelial cell migration,regulation of synaptic plasticityactin binding,receptor binding,protein binding,myosin binding,PDZ domain binding,protein homodimerization activity,cadherin bindingcytoplasm,cytosol,brush border,cell cortex,synaptic vesicle,vesicle membrane,membrane,endocytic vesicle,cytoplasmic vesicle,dendritic spine,dendritic shaft,extracellular e< xosomee>sp|O14908|GIPC1_HUMAN PDZ domain-containing protein GIPC1 OS=Homo sapiens OX=9606 GN=GIPC1 PE=1 SV=2P62829RPL23 RL23_HUMAN60S ribosomal protein L23nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,rRNA processing,translation,translational initiation,ribosomal protein import into nucleus,SRP-dependent cotranslational protein targeting to membrane,viral transcriptioncRNA binding,structural constituent of ribosome,protein binding,large ribosomal subunit rRNA bindingnucleolus,cytosol,ribosome,focal adhesion,membrane,cytosolic large ribosomal subunit,extracellular matrix,extracellular exosomeZ>sp|P62829|RL23_HUMAN 60S ribosomal protein L23 OS=Homo sapiens OX=9606 GN=RPL23 PE=1 SV=1Q92820GGH GGH_HUMANGamma-glutamyl hydrolaseproteolysis,glutamine metabolic process,response to zinc ion,response to insulin,response to drug,neutrophil degranulation,response to ethanolPexopeptidase activity,omega peptidase activity,gamma-glutamyl-peptidase activityextracellular region,extracellular space,nucleus,cytosol,azurophil granule lumen,specific granule lumen,melanosome,extracellular exosome,tertiary granule lumenV>sp|Q92820|GGH_HUMAN Gamma-glutamyl hydrolase OS=Homo sapiens OX=9606 GN=GGH PE=1 SV=2Q14767LTBP2 LTBP2_HUMAN8Latent-transforming growth factor beta-binding protein 2rprotein targeting,transforming growth factor beta receptor signaling pathway,protein secretion,fibril organizationIcalcium ion binding,protein binding,heparin binding,growth factor bindingoproteinaceous extracellular matrix,extracellular space,intracellular,extracellular exosome,extracellular matrixz>sp|Q14767|LTBP2_HUMAN Latent-transforming growth factor beta-binding protein 2 OS=Homo sapiens OX=9606 GN=LTBP2 PE=1 SV=3Q04446GBE1 GLGB_HUMAN!1,4-alpha-glucan-branching enzymegglycogen metabolic process,glycogen biosynthetic process,generation of precursor metabolites and energy1,4-alpha-glucan branching enzyme activity,hydrolase activity, hydrolyzing O-glycosyl compounds,protein binding,carbohydrate binding,cation bindinga>sp|Q04446|GLGB_HUMAN 1,4-alpha-glucan-branching enzyme OS=Homo sapiens OX=9606 GN=GBE1 PE=1 SV=3P55083MFAP4 MFAP4_HUMAN%Microfibril-associated glycoprotein 4cell adhesion,UV protection,regulation of collagen metabolic process,elastic fiber assembly,cellular response to UV-B,fibril organizationmicrofibril,extracellular region,proteinaceous extracellular matrix,extracellular space,extracellular matrix,extracellular exosome,elastic fiberg>sp|P55083|MFAP4_HUMAN Microfibril-associated glycoprotein 4 OS=Homo sapiens OX=9606 GN=MFAP4 PE=1 SV=2P21266GSTM3 GSTM3_HUMANGlutathione S-transferase Mu 3glutathione metabolic process,establishment of blood-nerve barrier,nitrobenzene metabolic process,xenobiotic catabolic process,response to estrogen,cellular detoxification of nitrogen compound,glutathione derivative biosynthetic processglutathione transferase activity,enzyme binding,identical protein binding,protein homodimerization activity,glutathione bindingDnucleus,cytoplasm,cytosol,sperm fibrous sheath,extracellular exosome`>sp|P21266|GSTM3_HUMAN Glutathione S-transferase Mu 3 OS=Homo sapiens OX=9606 GN=GSTM3 PE=1 SV=3O14773TPP1 TPP1_HUMANTripeptidyl-peptidase 1-proteolysis,lipid metabolic process,lysosome organization,nervous system development,central nervous system development,protein catabolic process,epithelial cell differentiation,IRE1-mediated unfolded protein response,peptide catabolic process,bone resorption,neuromuscular process controlling balanceendopeptidase activity,serine-type endopeptidase activity,protein binding,peptidase activity,serine-type peptidase activity,tripeptidyl-peptidase activity,peptide binding,metal ion bindingGmitochondrion,lysosome,melanosome,lysosomal lumen,extracellular exosomeW>sp|O14773|TPP1_HUMAN Tripeptidyl-peptidase 1 OS=Homo sapiens OX=9606 GN=TPP1 PE=1 SV=2Q96HE7ERO1A ERO1A_HUMANERO1-like protein alpharesponse to reactive oxygen species,protein folding,cellular protein modification process,response to temperature stimulus,animal organ senescence,4-hydroxyproline metabolic process,protein maturation by protein folding,extracellular matrix organization,endoplasmic reticulum unfolded protein response,protein folding in endoplasmic reticulum,response to endoplasmic reticulum stress,cell redox homeostasis,brown fat cell differentiation,chaperone mediated protein folding requiring cofactor,release of sequestered calcium ion into cytosol,oxidation-reduction process,intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress,cellular response to hypoxiaprotein disulfide isomerase activity,protein binding,protein disulfide oxidoreductase activity,disulfide oxidoreductase activity,oxidoreductase activity,oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptorendoplasmic reticulum,endoplasmic reticulum lumen,endoplasmic reticulum membrane,membrane,dendrite,intracellular membrane-bounded organelleY>sp|Q96HE7|ERO1A_HUMAN ERO1-like protein alpha OS=Homo sapiens OX=9606 GN=ERO1A PE=1 SV=2P49788RARRES1 TIG1_HUMAN*Retinoic acid receptor responder protein 1)negative regulation of cell proliferation4integral component of membrane,extracellular exosomem>sp|P49788|TIG1_HUMAN Retinoic acid receptor responder protein 1 OS=Homo sapiens OX=9606 GN=RARRES1 PE=1 SV=2P61604HSPE1 CH10_HUMAN(10 kDa heat shock protein, mitochondrialosteoblast differentiation,protein folding,activation of cysteine-type endopeptidase activity involved in apoptotic process,response to unfolded protein,chaperone mediated protein folding requiring cofactordRNA binding,protein binding,ATP binding,metal ion binding,unfolded protein binding,chaperone bindingAmitochondrion,mitochondrial matrix,membrane,extracellular exosomei>sp|P61604|CH10_HUMAN 10 kDa heat shock protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPE1 PE=1 SV=2P48444ARCN1 COPD_HUMANCoatomer subunit deltaintracellular protein transport,ER to Golgi vesicle-mediated transport,retrograde vesicle-mediated transport, Golgi to ER,adult locomotory behavior,cerebellar Purkinje cell layer maturation,pigmentationbGolgi membrane,endoplasmic reticulum membrane,cytosol,membrane,COPI vesicle coat,transport vesicleW>sp|P48444|COPD_HUMAN Coatomer subunit delta OS=Homo sapiens OX=9606 GN=ARCN1 PE=1 SV=1P17936IGFBP3 IBP3_HUMAN,Insulin-like growth factor-binding protein 3regulation of cell growth,osteoblast differentiation,negative regulation of protein phosphorylation,protein phosphorylation,apoptotic process,negative regulation of cell proliferation,negative regulation of signal transduction,regulation of glucose metabolic process,negative regulation of smooth muscle cell migration,regulation of apoptotic process,positive regulation of apoptotic process,positive regulation of catalytic activity,positive regulation of MAPK cascade,regulation of insulin-like growth factor receptor signaling pathway,positive regulation of insulin-like growth factor receptor signaling pathway,cellular protein metabolic process,type B pancreatic cell proliferation,positive regulation of myoblast differentiation,negative regulation of smooth muscle cell proliferationfibronectin binding,protein binding,insulin-like growth factor binding,protein tyrosine phosphatase activator activity,insulin-like growth factor I binding,insulin-like growth factor II binding,metal ion bindingextracellular region,extracellular space,nucleus,insulin-like growth factor binding protein complex,insulin-like growth factor ternary complex,extracellular exosomen>sp|P17936|IBP3_HUMAN Insulin-like growth factor-binding protein 3 OS=Homo sapiens OX=9606 GN=IGFBP3 PE=1 SV=2Q12797ASPH ASPH_HUMAN%Aspartyl/asparaginyl beta-hydroxylasemuscle contraction,pattern specification process,negative regulation of cell proliferation,regulation of protein stability,ion transmembrane transport,limb morphogenesis,peptidyl-aspartic acid hydroxylation,positive regulation of proteolysis,oxidation-reduction process,palate developm< ent,face morphogenesis,activation of cysteine-type endopeptidase activity,regulation of protein depolymerization,regulation of cardiac conductionpeptide-aspartate beta-dioxygenase activity,structural molecule activity,calcium ion binding,protein binding,structural constituent of muscle,electron carrier activityendoplasmic reticulum,endoplasmic reticulum membrane,plasma membrane,integral component of membrane,cortical endoplasmic reticulum,sarcoplasmic reticulum membranee>sp|Q12797|ASPH_HUMAN Aspartyl/asparaginyl beta-hydroxylase OS=Homo sapiens OX=9606 GN=ASPH PE=1 SV=3P40925MDH1 MDHC_HUMAN!Malate dehydrogenase, cytoplasmicwgluconeogenesis,tricarboxylic acid cycle,oxaloacetate metabolic process,malate metabolic process,NADH metabolic processymalic enzyme activity,protein binding,L-malate dehydrogenase activity,diiodophenylpyruvate reductase activity,NAD bindingMextracellular space,mitochondrion,cytosol,myelin sheath,extracellular exosomea>sp|P40925|MDHC_HUMAN Malate dehydrogenase, cytoplasmic OS=Homo sapiens OX=9606 GN=MDH1 PE=1 SV=4O76061STC2 STC2_HUMANStanniocalcin-2cellular calcium ion homeostasis,response to oxidative stress,embryo implantation,negative regulation of gene expression,endoplasmic reticulum unfolded protein response,response to vitamin D,negative regulation of multicellular organism growth,response to peptide hormone,decidualization,regulation of hormone biosynthetic process,cellular response to hypoxia,regulation of store-operated calcium entryNhormone activity,enzyme binding,heme binding,protein homodimerization activityYextracellular space,endoplasmic reticulum,Golgi apparatus,perinuclear region of cytoplasmO>sp|O76061|STC2_HUMAN Stanniocalcin-2 OS=Homo sapiens OX=9606 GN=STC2 PE=1 SV=1P14550AKR1A1 AK1A1_HUMAN&Aldo-keto reductase family 1 member A1glucose metabolic process,cellular aldehyde metabolic process,glucuronate catabolic process to xylulose 5-phosphate,L-ascorbic acid biosynthetic process,D-glucuronate catabolic process,aldehyde catabolic process,oxidation-reduction process,glutathione derivative biosynthetic processalditol:NADP+ 1-oxidoreductase activity,aldo-keto reductase (NADP) activity,protein binding,electron carrier activity,L-glucuronate reductase activityHextracellular space,cytosol,apical plasma membrane,extracellular exosomei>sp|P14550|AK1A1_HUMAN Aldo-keto reductase family 1 member A1 OS=Homo sapiens OX=9606 GN=AKR1A1 PE=1 SV=3P29966MARCKS MARCS_HUMAN-Myristoylated alanine-rich C-kinase substrateregulation of insulin secretionBprotein kinase C binding,calmodulin binding,actin filament bindingocentrosome,plasma membrane,focal adhesion,cell cortex,actin cytoskeleton,germinal vesicle,extracellular exosomep>sp|P29966|MARCS_HUMAN Myristoylated alanine-rich C-kinase substrate OS=Homo sapiens OX=9606 GN=MARCKS PE=1 SV=4P61225RAP2B RAP2B_HUMANRas-related protein Rap-2bBsignal transduction,platelet activation,negative regulation of cell migration,positive regulation of protein autophosphorylation,Rap protein signal transduction,neutrophil degranulation,regulation of protein tyrosine kinase activity,platelet aggregation,microvillus assembly,establishment of endothelial intestinal barrierGprotein binding,GTP binding,GDP binding,protein domain specific bindingcytosol,plasma membrane,bicellular tight junction,membrane,specific granule membrane,cell-cell contact zone,membrane raft,recycling endosome membrane,extracellular exosome,tertiary granule membrane\>sp|P61225|RAP2B_HUMAN Ras-related protein Rap-2b OS=Homo sapiens OX=9606 GN=RAP2B PE=1 SV=1P62266RPS23 RS23_HUMAN40S ribosomal protein S23Gnucleoplasm,cytosol,ribosome,membrane,cytosolic small ribosomal subunitZ>sp|P62266|RS23_HUMAN 40S ribosomal protein S23 OS=Homo sapiens OX=9606 GN=RPS23 PE=1 SV=3O15400STX7 STX7_HUMAN Syntaxin-7+positive regulation of T cell mediated cytotoxicity,intracellular protein transport,vesicle fusion,vesicle docking,organelle localization,regulation of molecular function,organelle assembly,positive regulation of receptor localization to synapse,regulation of protein localization to plasma membraneiSNARE binding,SNAP receptor activity,protein binding,chloride channel inhibitor activity,syntaxin binding2immunological synapse,lysosome,lysosomal membrane,endosome,early endosome,late endosome,plasma membrane,integral component of membrane,endocytic vesicle,SNARE complex,early endosome membrane,vesicle,azurophil granule,perinuclear region of cytoplasm,recycling endosome,extracellular exosome,tertiary granuleJ>sp|O15400|STX7_HUMAN Syntaxin-7 OS=Homo sapiens OX=9606 GN=STX7 PE=1 SV=4O60437PPL PEPL_HUMAN Periplakin'cytoskeleton organization,cornificationGstructural constituent of cytoskeleton,protein binding,cadherin binding]cornified envelope,nucleus,mitochondrion,cytosol,cytoskeleton,desmosome,extracellular exosomeI>sp|O60437|PEPL_HUMAN Periplakin OS=Homo sapiens OX=9606 GN=PPL PE=1 SV=4P20020ATP2B1 AT2B1_HUMAN-Plasma membrane calcium-transporting ATPase 1?neural retina development,transport,cellular calcium ion homeostasis,brain development,aging,response to cold,ion transmembrane transport,calcium ion transmembrane transport,cellular response to vitamin D,cellular response to corticosterone stimulus,Requires Ontology,calcium ion export,regulation of cardiac conductionxcalcium-transporting ATPase activity,protein binding,calmodulin binding,ATP binding,PDZ domain binding,metal ion bindingnucleus,plasma membrane,integral component of plasma membrane,cytoplasmic side of plasma membrane,membrane,basolateral plasma membrane,apical plasma membrane,dendritic spine membrane,neuronal cell body membrane,intracellular membrane-bounded organelle,membrane raft,extracellular exosomep>sp|P20020|AT2B1_HUMAN Plasma membrane calcium-transporting ATPase 1 OS=Homo sapiens OX=9606 GN=ATP2B1 PE=1 SV=4Q14195DPYSL3 DPYL3_HUMAN%Dihydropyrimidinase-related protein 3apositive regulation of neuron projection development,negative regulation of neuron projection development,negative regulation of cell migration,neuron development,response to axon injury,actin filament bundle assembly,protein homooligomerization,positive regulation of filopodium assembly,actin crosslink formation,cellular response to cytokine stimulusprotein binding,hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds,SH3 domain binding,filamin binding,chondroitin sulfate bindingbextracellular space,cytosol,lamellipodium,growth cone,filamentous actin,cell body,exocytic vesicleh>sp|Q14195|DPYL3_HUMAN Dihydropyrimidinase-related protein 3 OS=Homo sapiens OX=9606 GN=DPYSL3 PE=1 SV=1P10768ESD ESTD_HUMANS-formylglutathione hydrolase]biological_process,formaldehyde catabolic process,glutathione derivative biosynthetic processprotein binding,hydrolase activity, acting on ester bonds,S-formylglutathione hydrolase activity,identical protein binding,methylumbelliferyl-acetate deacetylase activity,carboxylic ester hydrolase activityEendoplasmic reticulum lumen,cytoplasmic vesicle,extracellular exosome\>sp|P10768|ESTD_HUMAN S-formylglutathione hydrolase OS=Homo sapiens OX=9606 GN=ESD PE=1 SV=2Q92597NDRG1 NDRG1_HUMAN Protein NDRG1'negative regulation of cell proliferation,response to metal ion,DNA damage response, signal transduction by p53 class mediator,peripheral nervous system myelin maintenance,regulation of apoptotic process,mast cell activation,cellular response to hypoxia,positive regulation of spindle checkpoint]protein binding,microtubule binding,Rab GTPase binding,gamma-tubulin binding,cadherin bindingnucleus,cytoplasm,centrosome,cytosol,microtubule,plasma membrane,cell-cell adherens junction,microtubule cytoskeleton,myelin sheath,perinuclear region of cytoplasm,recycling endosome membrane,extracellular exosomeO>sp|Q92597|NDRG1_HUMAN Protein NDRG1 OS=Homo sapiens OX=9606 GN=NDRG1 PE=1 SV=1O15498YKT6 YKT6_HUMANSynaptobrevin homolog YKT6ER to Golgi vesicle-mediated transport,vesicle targeting,vesicle docking involved in exocytosis,vesicle fusion,protein transport,retrograde< transport, endosome to GolgifSNARE binding,SNAP receptor activity,protein-cysteine S-palmitoyltransferase activity,cadherin bindingHGolgi membrane,cytoplasm,mitochondrion,endosome,endoplasmic reticulum,Golgi apparatus,cytosol,integral component of plasma membrane,transport vesicle,cytoplasmic vesicle membrane,SNARE complex,endoplasmic reticulum-Golgi intermediate compartment membrane,neuronal cell body,extracellular exosome,apical dendrite,basilar dendriteZ>sp|O15498|YKT6_HUMAN Synaptobrevin homolog YKT6 OS=Homo sapiens OX=9606 GN=YKT6 PE=1 SV=1Q96IJ6GMPPA GMPPA_HUMAN+Mannose-1-phosphate guanyltransferase alphabiosynthetic process/protein binding,nucleotidyltransferase activitym>sp|Q96IJ6|GMPPA_HUMAN Mannose-1-phosphate guanyltransferase alpha OS=Homo sapiens OX=9606 GN=GMPPA PE=1 SV=1Q32P28P3H1 P3H1_HUMANProlyl 3-hydroxylase 1Nprotein folding,negative regulation of cell proliferation,protein hydroxylation,peptidyl-proline hydroxylation,collagen metabolic process,regulation of protein secretion,protein stabilization,oxidation-reduction process,bone development,chaperone-mediated protein folding,negative regulation of post-translational protein modificationmolecular_function,iron ion binding,procollagen-proline 3-dioxygenase activity,L-ascorbic acid binding,protein complex binding,collagen bindingproteinaceous extracellular matrix,endoplasmic reticulum,endoplasmic reticulum lumen,membrane,macromolecular complex,extracellular exosomeV>sp|Q32P28|P3H1_HUMAN Prolyl 3-hydroxylase 1 OS=Homo sapiens OX=9606 GN=P3H1 PE=1 SV=2P02774GC VTDB_HUMANVitamin D-binding protein-vitamin D metabolic process,vitamin transportNactin binding,vitamin D binding,vitamin transporter activity,calcidiol bindingjextracellular region,extracellular space,cytosol,lysosomal lumen,extracellular exosome,blood microparticleW>sp|P02774|VTDB_HUMAN Vitamin D-binding protein OS=Homo sapiens OX=9606 GN=GC PE=1 SV=2P62753RPS6 RS6_HUMAN40S ribosomal protein S6G1/S transition of mitotic cell cycle,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,placenta development,T cell proliferation involved in immune response,rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,activation-induced cell death of T cells,mitotic nuclear division,mitotic cell cycle checkpoint,gastrulation,viral transcription,oogenesis stage,TOR signaling,T cell differentiation in thymus,ribosomal small subunit biogenesis,glucose homeostasis,positive regulation of apoptotic process,negative regulation of apoptotic process,erythrocyte developmentURNA binding,structural constituent of ribosome,protein binding,protein kinase bindingnucleus,nucleoplasm,nucleolus,cytosol,polysome,small ribosomal subunit,membrane,cytosolic small ribosomal subunit,dendrite,intracellular ribonucleoprotein complex,cytoplasmic ribonucleoprotein granule,cell body,perinuclear region of cytoplasmW>sp|P62753|RS6_HUMAN 40S ribosomal protein S6 OS=Homo sapiens OX=9606 GN=RPS6 PE=1 SV=1P61006RAB8A RAB8A_HUMANRas-related protein Rab-8AG2/M transition of mitotic cell cycle,vesicle docking involved in exocytosis,small GTPase mediated signal transduction,axonogenesis,protein secretion,cellular response to insulin stimulus,regulation of long-term neuronal synaptic plasticity,Golgi vesicle fusion to target membrane,regulation of protein transport,cilium morphogenesis,membrane organization,protein localization to plasma membrane,ciliary basal body docking,neurotransmitter receptor transport to postsynaptic membranerGTPase activity,protein binding,GTP binding,Rab GTPase binding,GDP binding,protein kinase binding,myosin V bindingGolgi membrane,centrosome,centriole,cytosol,plasma membrane,cilium,synaptic vesicle,postsynaptic density,trans-Golgi network transport vesicle,cytoplasmic vesicle membrane,phagocytic vesicle membrane,extracellular matrix,trans-Golgi network membrane,ciliary basal body,neuronal cell body,dendritic spine,phagocytic vesicle,recycling endosome membrane,extracellular exosome,ciliary base,Requires Ontology\>sp|P61006|RAB8A_HUMAN Ras-related protein Rab-8A OS=Homo sapiens OX=9606 GN=RAB8A PE=1 SV=1O75436VPS26A VP26A_HUMAN/Vacuolar protein sorting-associated protein 26Aintracellular protein transport,Wnt signaling pathway,regulation of macroautophagy,retrograde transport, endosome to Golgi,retrograde transport, endosome to plasma membrane,protein binding,protein transporter activitylysosome,endosome,early endosome,cytosol,endosome membrane,retromer complex,retromer, cargo-selective complex,vesicle,extracellular exosome,tubular endosomer>sp|O75436|VP26A_HUMAN Vacuolar protein sorting-associated protein 26A OS=Homo sapiens OX=9606 GN=VPS26A PE=1 SV=2P28062PSMB8 PSB8_HUMANProteasome subunit beta type-8MAPK cascade,protein polyubiquitination,stimulatory C-type lectin receptor signaling pathway,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent,regulation of cellular amino acid metabolic process,negative regulation of G2/M transition of mitotic cell cycle,viral process,protein deubiquitination,anaphase-promoting complex-dependent catabolic process,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process,tumor necrosis factor-mediated signaling pathway,NIK/NF-kappaB signaling,Fc-epsilon receptor signaling pathway,proteasome-mediated ubiquitin-dependent protein catabolic process,regulation of mRNA stability,fat cell differentiation,T cell receptor signaling pathway,negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition,regulation of endopeptidase activity,transmembrane transport,Wnt signaling pathway, planar cell polarity pathway,type I interferon signaling pathway,regulation of transcription from RNA polymerase II promoter in response to hypoxia,negative regulation of canonical Wnt signaling pathway,positive regulation of canonical Wnt signaling pathway5threonine-type endopeptidase activity,protein bindingoproteasome complex,nucleoplasm,cytosol,proteasome core complex,extracellular exosome,spermatoproteasome complex_>sp|P28062|PSB8_HUMAN Proteasome subunit beta type-8 OS=Homo sapiens OX=9606 GN=PSMB8 PE=1 SV=3Q16401PSMD5 PSMD5_HUMAN.26S proteasome non-ATPase regulatory subunit 5MAPK cascade,protein polyubiquitination,stimulatory C-type lectin receptor signaling pathway,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent,regulation of cellular amino acid metabolic process,negative regulation of G2/M transition of mitotic cell cycle,protein deubiquitination,anaphase-promoting complex-dependent catabolic process,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process,tumor necrosis factor-mediated signaling pathway,NIK/NF-kappaB signaling,Fc-epsilon receptor signaling pathway,proteasome-mediated ubiquitin-dependent protein catabolic process,regulation of mRNA stability,T cell receptor signaling pathway,negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition,transmembrane transport,Wnt signaling pathway, planar cell polarity pathway,regulation of transcription from RNA polymerase II promoter in response to hypoxia,proteasome regulatory particle assembly,negative regulation of canonical Wnt signaling pathway,positive regulation of canonical Wnt signaling pathwaysproteasome complex,nucleoplasm,cytosol,proteasome accessory complex,proteasome regulatory particle, base subcomplexp>sp|Q16401|PSMD5_HUMAN 26S proteasome non-ATPase regulatory subunit 5 OS=Homo sapiens OX=9606 GN=PSMD5 PE=1 SV=3Q9BT78COPS4 CSN4_HUMAN"COP9 signalosome complex subunit 40protein binding,NEDD8-specific protease activityonucleus,nucleoplasm,cytosol,synaptic vesicle,COP9 signalosome,nuclear speck,cell junction,extracellular exosomec>sp|Q9BT78|CSN4_HUMAN CO< P9 signalosome complex subunit 4 OS=Homo sapiens OX=9606 GN=COPS4 PE=1 SV=1O75891ALDH1L1 AL1L1_HUMAN1Cytosolic 10-formyltetrahydrofolate dehydrogenaseone-carbon metabolic process,biosynthetic process,10-formyltetrahydrofolate catabolic process,folic acid metabolic process,oxidation-reduction processcatalytic activity,aldehyde dehydrogenase (NAD) activity,formyltetrahydrofolate dehydrogenase activity,hydroxymethyl-, formyl- and related transferase activity+mitochondrion,cytosol,extracellular exosomeu>sp|O75891|AL1L1_HUMAN Cytosolic 10-formyltetrahydrofolate dehydrogenase OS=Homo sapiens OX=9606 GN=ALDH1L1 PE=1 SV=2Q14019COTL1 COTL1_HUMANCoactosin-like proteinFbiological_process,neutrophil degranulation,defense response to fungus,actin binding,protein binding,enzyme bindingtextracellular region,nucleus,cytoskeleton,secretory granule lumen,extracellular exosome,ficolin-1-rich granule lumenX>sp|Q14019|COTL1_HUMAN Coactosin-like protein OS=Homo sapiens OX=9606 GN=COTL1 PE=1 SV=3Q06033ITIH3 ITIH3_HUMAN,Inter-alpha-trypsin inhibitor heavy chain H3aplatelet degranulation,negative regulation of endopeptidase activity,hyaluronan metabolic processMendopeptidase inhibitor activity,serine-type endopeptidase inhibitor activityGextracellular region,platelet dense granule lumen,extracellular exosomen>sp|Q06033|ITIH3_HUMAN Inter-alpha-trypsin inhibitor heavy chain H3 OS=Homo sapiens OX=9606 GN=ITIH3 PE=1 SV=2Q6IAA8LAMTOR1 LTOR1_HUMAN!Ragulator complex protein LAMTOR1regulation of receptor recycling,endosome organization,lysosome organization,cell cycle arrest,regulation of cholesterol esterification,regulation of cholesterol efflux,cell growth,macroautophagy,positive regulation of TOR signaling,lysosome localization,endosome localization,cellular protein localization,cholesterol homeostasis,neutrophil degranulation,positive regulation of MAPK cascade,positive regulation of GTPase activity,regulation of cholesterol import,cellular response to amino acid stimulusSprotein binding,guanyl-nucleotide exchange factor activity,protein complex scaffoldlysosome,lysosomal membrane,plasma membrane,late endosome membrane,azurophil granule membrane,specific granule membrane,membrane raft,extracellular exosome,Ragulator complex,ficolin-1-rich granule membranee>sp|Q6IAA8|LTOR1_HUMAN Ragulator complex protein LAMTOR1 OS=Homo sapiens OX=9606 GN=LAMTOR1 PE=1 SV=2Q9UP95SLC12A4 S12A4_HUMAN!Solute carrier family 12 member 4transport,ion transport,cell volume homeostasis,chemical synaptic transmission,potassium ion transmembrane transport,chloride transmembrane transport]potassium:chloride symporter activity,protein kinase binding,potassium ion symporter activityQlysosomal membrane,plasma membrane,integral component of plasma membrane,membranee>sp|Q9UP95|S12A4_HUMAN Solute carrier family 12 member 4 OS=Homo sapiens OX=9606 GN=SLC12A4 PE=1 SV=2Q13740ALCAM CD166_HUMAN CD166 antigen adaptive immune response,cell adhesion,heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules,signal transduction,motor neuron axon guidance,retinal ganglion cell axon guidance,axon extension involved in axon guidance,neuron projection extension receptor binding,protein bindingimmunological synapse,integral component of plasma membrane,focal adhesion,external side of plasma membrane,axon,dendrite,intrinsic component of plasma membrane,neuronal cell body,extracellular exosome,T cell receptor complexO>sp|Q13740|CD166_HUMAN CD166 antigen OS=Homo sapiens OX=9606 GN=ALCAM PE=1 SV=2Q99497PARK7 PARK7_HUMANParkinson disease protein 7Nnegative regulation of protein phosphorylation,positive regulation of acute inflammatory response to antigenic stimulus,negative regulation of protein kinase activity,proteolysis,protein deglycosylation,autophagy,inflammatory response,mitochondrion organization,Ras protein signal transduction,single fertilization,adult locomotory behavior,methylglyoxal metabolic process,detoxification of copper ion,positive regulation of gene expression,negative regulation of gene expression,enzyme active site formation via L-cysteine sulfinic acid,lactate biosynthetic process,negative regulation of protein ubiquitination,negative regulation of protein binding,activation of protein kinase B activity,negative regulation of proteasomal ubiquitin-dependent protein catabolic process,positive regulation of interleukin-8 production,positive regulation of peptidyl-serine phosphorylation,negative regulation of protein sumoylation,positive regulation of NAD(P)H oxidase activity,cellular response to oxidative stress,cellular response to glyoxal,peptidyl-cysteine deglycation,peptidyl-arginine deglycation,peptidyl-lysine deglycation,protein deglycation, glyoxal removal,protein deglycation, methylglyoxal removal,glutathione deglycation,hydrogen peroxide metabolic process,negative regulation of apoptotic process,regulation of neuron apoptotic process,negative regulation of neuron apoptotic process,positive regulation of transcription from RNA polymerase II promoter,glycolate biosynthetic process,negative regulation of protein export from nucleus,regulation of inflammatory response,detoxification of mercury ion,protein stabilization,positive regulation of sequence-specific DNA binding transcription factor activity,negative regulation of ubiquitin-protein transferase activity,dopamine uptake involved in synaptic transmission,regulation of mitochondrial membrane potential,positive regulation of protein kinase B signaling,membrane depolarization,membrane hyperpolarization,negative regulation of cell death,regulation of androgen receptor signaling pathway,cellular response to hydrogen peroxide,positive regulation of protein homodimerization activity,cellular oxidant detoxification,positive regulation of protein localization to nucleus,negative regulation of neuron death,positive regulation of superoxide dismutase activity,negative regulation of protein acetylation,positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway,negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway,regulation of fibril organization,positive regulation of mitochondrial electron transport, NADH to ubiquinone,negative regulation of death-inducing signaling complex assembly,negative regulation of protein K48-linked deubiquitination,negative regulation of TRAIL-activated apoptotic signaling pathway,positive regulation of pyrroline-5-carboxylate reductase activity,positive regulation of tyrosine 3-monooxygenase activity,positive regulation of dopamine biosynthetic process,glyoxal metabolic process,positive regulation of L-dopa biosynthetic process,positive regulation of L-dopa decarboxylase activity,negative regulation of oxidative stress-induced cell death,negative regulation of hydrogen peroxide-induced cell death,negative regulation of hydrogen peroxide-induced neuron death,negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway,negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway,positive regulation of reactive oxygen species biosynthetic process,positive regulation of mitophagy,negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway,negative regulation of ubiquitin-specific protease activity,positive regulation of oxidative phosphorylation uncoupler activity,positive regulation of transcription regulatory region DNA binding,positive regulation of androgen receptor activity,negative regulation of extrinsic apoptotic signaling pathway,negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway,regulation of TRAIL receptor biosynthetic process^transcription coactivator activity,mRNA binding,receptor binding,copper ion binding,protein binding,transcription factor binding,peptidase activity,superoxide dismutase copper chaperone activity,oxidoreductase activity, acting on peroxide as acceptor,enzyme binding,kinase binding,cytokine binding,tyrosine 3-monooxygenase activator activity,L-dopa decarboxylase activat< or activity,protein deglycase activity,identical protein binding,protein homodimerization activity,small protein activating enzyme binding,ubiquitin-like protein conjugating enzyme binding,cadherin binding,mercury ion binding,androgen receptor binding,peroxiredoxin activity,repressing transcription factor binding,scaffold protein binding,cupric ion binding,cuprous ion binding,ubiquitin-specific protease binding,core promoter binding,double-stranded DNA binding,single-stranded DNA binding;chromatin,nucleus,cytoplasm,mitochondrion,mitochondrial intermembrane space,mitochondrial matrix,endoplasmic reticulum,cytosol,plasma membrane,cell-cell adherens junction,PML body,axon,cell body,membrane raft,perinuclear region of cytoplasm,extracellular exosome,presynapse,mitochondrial respiratory chain complex I]>sp|Q99497|PARK7_HUMAN Parkinson disease protein 7 OS=Homo sapiens OX=9606 GN=PARK7 PE=1 SV=2Q9P253VPS18 VPS18_HUMAN6Vacuolar protein sorting-associated protein 18 homologintracellular protein transport,vesicle docking involved in exocytosis,autophagy,endosome organization,lysosome organization,endosome to lysosome transport,regulation of SNARE complex assembly,viral entry into host cellZactin binding,protein binding,syntaxin binding,protein binding, bridging,metal ion bindinglysosome,lysosomal membrane,early endosome,late endosome,autophagosome,actin filament,AP-3 adaptor complex,clathrin-coated vesicle,HOPS complex,late endosome membrane,CORVET complexx>sp|Q9P253|VPS18_HUMAN Vacuolar protein sorting-associated protein 18 homolog OS=Homo sapiens OX=9606 GN=VPS18 PE=1 SV=2P45974USP5 UBP5_HUMAN'Ubiquitin carboxyl-terminal hydrolase 5ubiquitin-dependent protein catabolic process,protein ubiquitination,protein deubiquitination,positive regulation of proteasomal ubiquitin-dependent protein catabolic process,protein K48-linked deubiquitinationcysteine-type endopeptidase activity,thiol-dependent ubiquitin-specific protease activity,protein binding,zinc ion binding,thiol-dependent ubiquitinyl hydrolase activity,ubiquitin bindinglysosome,cytosolg>sp|P45974|UBP5_HUMAN Ubiquitin carboxyl-terminal hydrolase 5 OS=Homo sapiens OX=9606 GN=USP5 PE=1 SV=2P49588AARS1 SYAC_HUMAN!Alanine--tRNA ligase, cytoplasmichair follicle development,tRNA modification,tRNA aminoacylation for protein translation,alanyl-tRNA aminoacylation,regulation of translational fidelity,protein folding,tRNA processing,cerebellar Purkinje cell layer development,endoplasmic reticulum unfolded protein response,response to amino acid,negative regulation of neuron apoptotic process,neuromuscular process controlling balanceztRNA binding,aminoacyl-tRNA editing activity,alanine-tRNA ligase activity,ATP binding,amino acid binding,metal ion binding>cytoplasm,cytosol,membrane,extracellular exosome,mitochondrionb>sp|P49588|SYAC_HUMAN Alanine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=AARS1 PE=1 SV=2Q9UI12ATP6V1H VATH_HUMANV-type proton ATPase subunit H4endocytosis,vacuolar acidification,insulin receptor signaling pathway,ATP hydrolysis coupled proton transport,viral process,regulation of macroautophagy,transferrin transport,ion transmembrane transport,regulation of defense response to virus by virus,regulation of catalytic activity,phagosome acidificationsprotein binding,enzyme regulator activity,proton-transporting ATPase activity, rotational mechanism,ATPase activityvvacuolar proton-transporting V-type ATPase, V1 domain,lysosomal membrane,cytosol,plasma membrane,extracellular exosomea>sp|Q9UI12|VATH_HUMAN V-type proton ATPase subunit H OS=Homo sapiens OX=9606 GN=ATP6V1H PE=1 SV=1P78559MAP1A MAP1A_HUMAN!Microtubule-associated protein 1A%microtubule cytoskeleton organization@structural molecule activity,protein binding,microtubule binding4cytoplasm,microtubule,microtubule associated complexc>sp|P78559|MAP1A_HUMAN Microtubule-associated protein 1A OS=Homo sapiens OX=9606 GN=MAP1A PE=1 SV=6Q9NQW7XPNPEP1 XPP1_HUMANXaa-Pro aminopeptidase 1(proteolysis,bradykinin catabolic processnaminopeptidase activity,manganese ion binding,protein homodimerization activity,metalloaminopeptidase activity[>sp|Q9NQW7|XPP1_HUMAN Xaa-Pro aminopeptidase 1 OS=Homo sapiens OX=9606 GN=XPNPEP1 PE=1 SV=3P32969RPL9 RL9_HUMAN60S ribosomal protein L9gnucleus,cytosol,ribosome,focal adhesion,membrane,cytosolic large ribosomal subunit,extracellular matrixW>sp|P32969|RL9_HUMAN 60S ribosomal protein L9 OS=Homo sapiens OX=9606 GN=RPL9 PE=1 SV=1P20337RAB3B RAB3B_HUMANRas-related protein Rab-3Bsmall GTPase mediated signal transduction,protein transport,regulation of exocytosis,peptidyl-cysteine methylation,antigen processing and presentation,positive regulation of dopamine uptake involved in synaptic transmission,regulation of vesicle sizefGTPase activity,protein binding,GTP binding,GDP binding,GTP-dependent protein binding,myosin V bindingcytoplasm,cytosol,plasma membrane,synaptic vesicle,secretory granule,vesicle,perinuclear region of cytoplasm,extracellular exosome\>sp|P20337|RAB3B_HUMAN Ras-related protein Rab-3B OS=Homo sapiens OX=9606 GN=RAB3B PE=1 SV=2P62917RPL8 RL8_HUMAN60S ribosomal protein L8nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,cytoplasmic translation,rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,viral transcription,cellular response to nerve growth factor stimulus@RNA binding,structural constituent of ribosome,5.8S rRNA bindingW>sp|P62917|RL8_HUMAN 60S ribosomal protein L8 OS=Homo sapiens OX=9606 GN=RPL8 PE=1 SV=2O60565GREM1 GREM1_HUMAN Gremlin-1cell morphogenesis,branching involved in ureteric bud morphogenesis,cell migration involved in sprouting angiogenesis,positive regulation of receptor internalization,positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation,mesenchymal to epithelial transition involved in metanephros morphogenesis,apoptotic process,signal transduction,activation of transmembrane receptor protein tyrosine kinase activity,cell-cell signaling,positive regulation of cell proliferation,proximal/distal pattern formation,regulation of epithelial to mesenchymal transition,collagen fibril organization,negative regulation of cell growth,embryonic limb morphogenesis,negative regulation of bone mineralization,negative regulation of BMP signaling pathway,negative regulation of chondrocyte differentiation,negative regulation of osteoblast proliferation,positive regulation of NF-kappaB import into nucleus,negative regulation of apoptotic process,positive regulation of angiogenesis,negative regulation of transcription, DNA-templated,positive regulation of transcription from RNA polymerase II promoter,negative regulation of bone remodeling,determination of dorsal identity,positive regulation of NF-kappaB transcription factor activity,regulation of focal adhesion assembly,positive regulation of telomerase activity,limb development,negative regulation of pathway-restricted SMAD protein phosphorylation,ureteric bud formation,positive regulation of protein tyrosine kinase activity,negative regulation of monocyte chemotaxis,negative regulation of canonical Wnt signaling pathway,positive regulation of branching involved in ureteric bud morphogenesis,negative regulation of branching involved in ureteric bud morphogenesis,negative regulation of osteoclast proliferation,positive regulation of peptidyl-tyrosine autophosphorylation,negative regulation of bone trabecula formation,negative regulation of bone mineralization involved in bone maturation,positive regulation of receptor activity,positive regulation of cardiac muscle cell differentiation,regulation of stress-activated MAPK cascade,signal transduction by p53 class mediatorcytokine activity,protein binding,morphogen activity,transmembrane receptor protein tyrosine kinase activator activity,BMP binding,vascular endothelial growth factor receptor 2 binding,receptor agonist activity extracellular space,cell surfaceK>sp|O60565|GREM1_HUMAN Gremlin-1 OS< =Homo sapiens OX=9606 GN=GREM1 PE=1 SV=1Q02543RPL18A RL18A_HUMAN60S ribosomal protein L18anuclear-transcribed mRNA catabolic process, nonsense-mediated decay,rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,viral transcription,response to antineoplastic agent]>sp|Q02543|RL18A_HUMAN 60S ribosomal protein L18a OS=Homo sapiens OX=9606 GN=RPL18A PE=1 SV=2P02538KRT6A K2C6A_HUMAN Keratin, type II cytoskeletal 6Amorphogenesis of an epithelium,cytoskeleton organization,positive regulation of cell proliferation,cell differentiation,keratinization,wound healing,cornification?nucleus,cytosol,membrane,keratin filament,extracellular exosomeb>sp|P02538|K2C6A_HUMAN Keratin, type II cytoskeletal 6A OS=Homo sapiens OX=9606 GN=KRT6A PE=1 SV=3P05121SERPINE1 PAI1_HUMAN!Plasminogen activator inhibitor 1chronological cell aging,angiogenesis,platelet degranulation,circadian rhythm,regulation of receptor activity,negative regulation of plasminogen activation,negative regulation of endopeptidase activity,negative regulation of smooth muscle cell migration,positive regulation of blood coagulation,negative regulation of blood coagulation,extracellular matrix organization,negative regulation of cell migration,positive regulation of interleukin-8 production,negative regulation of cell adhesion mediated by integrin,positive regulation of leukotriene production involved in inflammatory response,fibrinolysis,positive regulation of angiogenesis,positive regulation of transcription from RNA polymerase II promoter,positive regulation of receptor-mediated endocytosis,positive regulation of inflammatory response,defense response to Gram-negative bacterium,negative regulation of fibrinolysis,negative regulation of vascular wound healing,negative regulation of wound healing,cellular response to lipopolysaccharide,positive regulation of monocyte chemotaxis,negative regulation of extrinsic apoptotic signaling pathway via death domain receptors,negative regulation of smooth muscle cell-matrix adhesion,negative regulation of endothelial cell apoptotic process^protease binding,serine-type endopeptidase inhibitor activity,receptor binding,protein bindingextracellular region,extracellular space,plasma membrane,extracellular matrix,platelet alpha granule lumen,extracellular exosomee>sp|P05121|PAI1_HUMAN Plasminogen activator inhibitor 1 OS=Homo sapiens OX=9606 GN=SERPINE1 PE=1 SV=1P62244RPS15A RS15A_HUMAN40S ribosomal protein S15a&nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,positive regulation of cell proliferation,response to virus,viral transcription,positive regulation of cell cyclenucleoplasm,cytoplasm,mitochondrion,cytosol,membrane,cytosolic small ribosomal subunit,extracellular matrix,extracellular exosome]>sp|P62244|RS15A_HUMAN 40S ribosomal protein S15a OS=Homo sapiens OX=9606 GN=RPS15A PE=1 SV=2P49755TMED10 TMEDA_HUMAN0Transmembrane emp24 domain-containing protein 10kidney development,intracellular protein transport,ER to Golgi vesicle-mediated transport,retrograde vesicle-mediated transport, Golgi to ER,Golgi organization,cargo loading into vesicle,COPI-coated vesicle budding,response to alkaloid,regulated exocytosis,vesicle targeting, to, from or within Golgi,COPI coating of Golgi vesicle,COPII vesicle coating,protein oligomerization,regulation of beta-amyloid formation8protein binding,syntaxin binding,protein complex bindingGolgi membrane,endoplasmic reticulum,endoplasmic reticulum membrane,endoplasmic reticulum-Golgi intermediate compartment,Golgi apparatus,cis-Golgi network,plasma membrane,ER to Golgi transport vesicle membrane,integral component of membrane,transport vesicle,COPI-coated vesicle,trans-Golgi network transport vesicle,secretory granule membrane,endoplasmic reticulum-Golgi intermediate compartment membrane,melanosome,zymogen granule membrane,extracellular exosome,gamma-secretase complexs>sp|P49755|TMEDA_HUMAN Transmembrane emp24 domain-containing protein 10 OS=Homo sapiens OX=9606 GN=TMED10 PE=1 SV=2Q12905ILF2 ILF2_HUMAN%Interleukin enhancer-binding factor 2itranscription, DNA-templated,neutrophil degranulation,positive regulation of transcription, DNA-templateddDNA binding,RNA binding,double-stranded RNA binding,protein binding,ATP binding,transferase activityextracellular region,nucleus,nucleolus,membrane,intracellular ribonucleoprotein complex,specific granule lumen,tertiary granule lumen,ficolin-1-rich granule lumene>sp|Q12905|ILF2_HUMAN Interleukin enhancer-binding factor 2 OS=Homo sapiens OX=9606 GN=ILF2 PE=1 SV=2O75390CS CISY_HUMANCitrate synthase, mitochondrial7carbohydrate metabolic process,tricarboxylic acid cycle*RNA binding,citrate (Si)-synthase activity@nucleus,mitochondrion,mitochondrial matrix,extracellular exosome]>sp|O75390|CISY_HUMAN Citrate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=CS PE=1 SV=2O60763USO1 USO1_HUMAN'General vesicular transport factor p115intracellular protein transport,ER to Golgi vesicle-mediated transport,Golgi organization,transcytosis,COPII vesicle coating,Golgi vesicle docking,vesicle fusion with Golgi apparatus,membrane fusionIRNA binding,protein binding,protein transporter activity,cadherin bindingGolgi membrane,fibrillar center,endoplasmic reticulum,Golgi apparatus,Golgi stack,cytosol,ER to Golgi transport vesicle membrane,membrane,transport vesicle,perinuclear region of cytoplasmg>sp|O60763|USO1_HUMAN General vesicular transport factor p115 OS=Homo sapiens OX=9606 GN=USO1 PE=1 SV=2P18621RPL17 RL17_HUMAN60S ribosomal protein L171nucleus,cytosol,cytosolic large ribosomal subunitZ>sp|P18621|RL17_HUMAN 60S ribosomal protein L17 OS=Homo sapiens OX=9606 GN=RPL17 PE=1 SV=3Q9Y240CLEC11A CLC11_HUMAN'C-type lectin domain family 11 member A+growth factor activity,carbohydrate binding2extracellular region,extracellular space,cytoplasmk>sp|Q9Y240|CLC11_HUMAN C-type lectin domain family 11 member A OS=Homo sapiens OX=9606 GN=CLEC11A PE=1 SV=1Q96FW1OTUB1 OTUB1_HUMANUbiquitin thioesterase OTUB1adaptive immune response,DNA repair,cellular response to DNA damage stimulus,protein deubiquitination,protein K48-linked deubiquitination,cellular response to interleukin-1,negative regulation of histone H2A K63-linked ubiquitination,negative regulation of double-strand break repairthiol-dependent ubiquitin-specific protease activity,protein binding,NEDD8-specific protease activity,ubiquitin protein ligase binding,ubiquitin binding1nucleus,nucleoplasm,cytosol,extracellular exosome^>sp|Q96FW1|OTUB1_HUMAN Ubiquitin thioesterase OTUB1 OS=Homo sapiens OX=9606 GN=OTUB1 PE=1 SV=2P40926MDH2 MDHM_HUMAN#Malate dehydrogenase, mitochondrialgluconeogenesis,tricarboxylic acid cycle,oxaloacetate metabolic process,malate metabolic process,internal protein amino acid acetylation,NADH metabolic processjRNA binding,L-malate dehydrogenase activity,protein self-association,malate dehydrogenase (NADP+) activityknucleus,mitochondrion,mitochondrial inner membrane,mitochondrial matrix,myelin sheath,extracellular exosomec>sp|P40926|MDHM_HUMAN Malate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=MDH2 PE=1 SV=3Q92973TNPO1 TNPO1_HUMAN Transportin-1protein import into nucleus, translocation,NLS-bearing protein import into nucleus,ribosomal protein import into nucleus,viral process,intraciliary transport involved in cilium morphogenesis,regulation of mRNA stabilityqRNA binding,protein binding,nuclear localization sequence binding,Ran GTPase binding,protein transporter activityYnucleus,cytoplasm,cytosol,cilium,nuclear membrane,nuclear periphery,extracellular exosomeO>sp|Q92973|TNPO1_HUMAN Transportin-1 OS=Homo sapiens OX=9606 GN=TNPO1 PE=1 SV=2P12268IMPDH2 IMDH2_HUMAN(Inosine-5'-monophosphate dehydrogenase 2GMP biosynthetic process,GTP biosynthetic process,purine ribonucleoside monophosphate biosynthetic process,neutrophil degranulation< ,lymphocyte proliferation,protein homotetramerization,oxidation-reduction process,retina development in camera-type eye,cellular response to interleukin-4gnucleotide binding,DNA binding,RNA binding,IMP dehydrogenase activity,protein binding,metal ion bindingextracellular region,nucleus,cytoplasm,peroxisomal membrane,cytosol,membrane,secretory granule lumen,extracellular exosome,ficolin-1-rich granule lumenk>sp|P12268|IMDH2_HUMAN Inosine-5'-monophosphate dehydrogenase 2 OS=Homo sapiens OX=9606 GN=IMPDH2 PE=1 SV=2P60953CDC42 CDC42_HUMAN(Cell division control protein 42 homolog sprouting angiogenesis,cardiac conduction system development,keratinocyte development,Golgi organization,regulation of mitotic nuclear division,nuclear migration,establishment or maintenance of cell polarity,blood coagulation,positive regulation of gene expression,negative regulation of gene expression,protein ubiquitination,substantia nigra development,actin cytoskeleton organization,macrophage differentiation,positive regulation of cell growth,hair follicle morphogenesis,positive regulation of pseudopodium assembly,T cell costimulation,negative regulation of protein complex assembly,keratinization,regulation of protein stability,positive regulation of cytokinesis,Cdc42 protein signal transduction,positive regulation of peptidyl-serine phosphorylation,adherens junction organization,cellular protein localization,establishment or maintenance of apical/basal cell polarity,multicellular organism growth,dendritic cell migration,Fc-gamma receptor signaling pathway involved in phagocytosis,viral RNA genome replication,negative regulation of epidermal growth factor receptor signaling pathway,regulation of protein catabolic process,regulation of protein heterodimerization activity,positive regulation of neuron apoptotic process,positive regulation of phosphatidylinositol 3-kinase activity,positive regulation of DNA replication,regulation of protein kinase activity,positive regulation of JNK cascade,filopodium assembly,vascular endothelial growth factor receptor signaling pathway,ephrin receptor signaling pathway,neuron fate determination,actin filament bundle assembly,regulation of small GTPase mediated signal transduction,positive regulation of muscle cell differentiation,regulation of filopodium assembly,positive regulation of filopodium assembly,establishment of Golgi localization,positive regulation of synapse structural plasticity,regulation of attachment of spindle microtubules to kinetochore,heart contraction,canonical Wnt signaling pathway,Wnt signaling pathway, planar cell polarity pathway,positive regulation of epithelial cell proliferation involved in lung morphogenesis,submandibular salivary gland formation,epithelial-mesenchymal cell signaling,hair follicle placode formation,dendritic spine morphogenesis,positive regulation of hair follicle cell proliferation,organelle transport along microtubule,actin filament branching,epithelial cell-cell adhesion,positive regulation of intracellular protein transport,modification of synaptic structure,positive regulation of substrate adhesion-dependent cell spreading3GTPase activity,protein binding,GTP binding,protein kinase binding,GTP-dependent protein binding,mitogen-activated protein kinase kinase kinase binding,thioesterase binding,apolipoprotein A-I receptor binding,identical protein binding,Rho GDP-dissociation inhibitor binding,ubiquitin protein ligase activityGolgi membrane,storage vacuole,cytoplasm,endoplasmic reticulum membrane,microtubule organizing center,cytosol,plasma membrane,cell-cell junction,focal adhesion,membrane,secretory granule,filopodium,midbody,leading edge membrane,cytoplasmic ribonucleoprotein granule,neuron projection,neuronal cell body,dendritic spine,myelin sheath,apical part of cell,spindle midzone,extracellular exosome,mitotic spindlej>sp|P60953|CDC42_HUMAN Cell division control protein 42 homolog OS=Homo sapiens OX=9606 GN=CDC42 PE=1 SV=2P16112ACAN PGCA_HUMANAggrecan core proteinskeletal system development,proteolysis,cell adhesion,central nervous system development,keratan sulfate biosynthetic process,extracellular matrix disassembly,extracellular matrix organization,keratan sulfate catabolic processzextracellular matrix structural constituent,protein binding,hyaluronic acid binding,carbohydrate binding,metal ion bindinghextracellular region,proteinaceous extracellular matrix,Golgi lumen,lysosomal lumen,extracellular matrixU>sp|P16112|PGCA_HUMAN Aggrecan core protein OS=Homo sapiens OX=9606 GN=ACAN PE=1 SV=3P46379BAG6 BAG6_HUMANLarge proline-rich protein BAG6Bkidney development,immune response-activating cell surface receptor signaling pathway,ubiquitin-dependent protein catabolic process,transport,apoptotic process,synaptonemal complex assembly,spermatogenesis,brain development,embryo development,chromatin modification,internal peptidyl-lysine acetylation,natural killer cell activation,cell differentiation,lung development,ER-associated ubiquitin-dependent protein catabolic process,negative regulation of proteasomal ubiquitin-dependent protein catabolic process,regulation of cell proliferation,intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator,negative regulation of apoptotic process,negative regulation of proteolysis,protein stabilization,intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress,ER-associated misfolded protein catabolic process,tail-anchored membrane protein insertion into ER membrane,positive regulation of ERAD pathway,maintenance of unfolded protein involved in ERAD pathway,protein localization to cytosolic proteasome complex involved in ERAD pathwayreceptor binding,protein binding,toxic substance binding,Hsp70 protein binding,polyubiquitin binding,ubiquitin protein ligase binding,ribosome binding,misfolded protein binding,proteasome binding,ubiquitin-specific protease bindingznucleus,nucleoplasm,cytoplasm,cytosol,membrane,intracellular membrane-bounded organelle,extracellular exosome,BAT3 complex_>sp|P46379|BAG6_HUMAN Large proline-rich protein BAG6 OS=Homo sapiens OX=9606 GN=BAG6 PE=1 SV=2P16401H1-5 H15_HUMAN Histone H1.5 negative regulation of transcription from RNA polymerase II promoter,chromatin organization,nucleosome assembly,positive regulation of cell growth,protein stabilization,positive regulation of histone H3-K9 methylation,establishment of protein localization to chromatin=RNA binding,chromatin DNA binding,histone deacetylase bindingJnucleosome,nuclear chromatin,nuclear heterochromatin,extracellular exosomeK>sp|P16401|H15_HUMAN Histone H1.5 OS=Homo sapiens OX=9606 GN=H1-5 PE=1 SV=3P35625TIMP3 TIMP3_HUMANMetalloproteinase inhibitor 3Qplatelet degranulation,visual perception,response to organic substance,negative regulation of membrane protein ectodomain proteolysis,negative regulation of ERK1 and ERK2 cascade,cellular response to organic substance,positive regulation of TRAIL-activated apoptotic signaling pathway,negative regulation of metalloendopeptidase activityZprotease binding,protein binding,metalloendopeptidase inhibitor activity,metal ion bindingextracellular region,proteinaceous extracellular matrix,basement membrane,extracellular space,nucleus,platelet dense granule lumen,extracellular exosome,extracellular matrix_>sp|P35625|TIMP3_HUMAN Metalloproteinase inhibitor 3 OS=Homo sapiens OX=9606 GN=TIMP3 PE=1 SV=2O43505B4GAT1 B4GA1_HUMAN Beta-1,4-glucuronyltransferase 1protein O-linked glycosylation,axon guidance,keratan sulfate biosynthetic process,poly-N-acetyllactosamine biosynthetic process,protein O-linked mannosylationzN-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity,glucuronosyltransferase activity,metal ion bindingYGolgi membrane,Golgi apparatus,integral component of Golgi membrane,extracellular exosomec>sp|O43505|B4GA1_HUMAN Beta-1,4-glucuronyltransferase 1 OS=Homo sapiens OX=9606 GN=B4GAT1 PE=1 SV=1Q93063EXT2 EXT2_HUMAN Exostosin-2Aossification,mesoderm formation,glycosaminoglycan biosynthetic process,protein glycosylation,signal transduction,heparan sulfate < proteoglycan biosynthetic process,heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process,cell differentiation,cellular polysaccharide biosynthetic processprotein binding,glucuronosyltransferase activity,transferase activity, transferring glycosyl groups,heparan sulfate N-acetylglucosaminyltransferase activity,metal ion binding,protein heterodimerization activity,glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity,N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity,protein homodimerization activity,acetylglucosaminyltransferase activityGolgi membrane,endoplasmic reticulum,endoplasmic reticulum membrane,Golgi apparatus,membrane,integral component of membrane,UDP-N-acetylglucosamine transferase complex,extracellular exosomeK>sp|Q93063|EXT2_HUMAN Exostosin-2 OS=Homo sapiens OX=9606 GN=EXT2 PE=1 SV=1Q9Y2J2EPB41L3 E41L3_HUMANBand 4.1-like protein 3regulation of cell growth,protein localization to paranode region of axon,apoptotic process,cytoskeletal anchoring at plasma membrane,biological_process,regulation of cell shape,cortical cytoskeleton organization,cortical actin cytoskeleton organization,paranodal junction assembly,actomyosin structure organization,myelin maintenance,neuron projection morphogenesis,protein localization to juxtaparanode region of axon,protein localization to plasma membraneDactin binding,structural constituent of cytoskeleton,protein bindingcytosol,cytoskeleton,plasma membrane,cell-cell junction,postsynaptic density,extrinsic component of membrane,paranode region of axon,juxtaparanode region of axon,axolemma[>sp|Q9Y2J2|E41L3_HUMAN Band 4.1-like protein 3 OS=Homo sapiens OX=9606 GN=EPB41L3 PE=1 SV=2P21926CD9 CD9_HUMAN CD9 antigenplatelet degranulation,movement of cell or subcellular component,cell adhesion,cell surface receptor signaling pathway,fusion of sperm to egg plasma membrane,brain development,negative regulation of cell proliferation,response to water deprivation,oligodendrocyte development,platelet activation,paranodal junction assembly,receptor internalization,cellular response to low-density lipoprotein particle stimulus+extracellular space,plasma membrane,integral component of plasma membrane,focal adhesion,external side of plasma membrane,membrane,apical plasma membrane,endocytic vesicle membrane,clathrin-coated endocytic vesicle membrane,platelet alpha granule membrane,extracellular exosome,extracellular vesicleI>sp|P21926|CD9_HUMAN CD9 antigen OS=Homo sapiens OX=9606 GN=CD9 PE=1 SV=4P23921RRM1 RIR1_HUMAN2Ribonucleoside-diphosphate reductase large subunit^mitotic cell cycle,pyrimidine nucleobase metabolic process,DNA replication,male gonad development,deoxyribonucleotide biosynthetic process,response to ionizing radiation,nucleobase-containing small molecule interconversion,cell proliferation in forebrain,protein heterotetramerization,oxidation-reduction process,retina development in camera-type eyelribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor,protein binding,ATP bindingQnuclear envelope,cytosol,cell projection,neuronal cell body,extracellular exosomer>sp|P23921|RIR1_HUMAN Ribonucleoside-diphosphate reductase large subunit OS=Homo sapiens OX=9606 GN=RRM1 PE=1 SV=1Q16181SEPTIN7 SEPT7_HUMANSeptin-7cytokinesis,mitotic nuclear division,spermatogenesis,regulation of embryonic cell shape,cell differentiation,protein heterooligomerization,cilium morphogenesis,positive regulation of nonmotile primary cilium assemblycstructural molecule activity,protein binding,GTP binding,identical protein binding,cadherin bindingcondensed chromosome kinetochore,stress fiber,nucleus,spindle,cytosol,axoneme,midbody,septin complex,cleavage furrow,extracellular exosome,sperm annulus,Requires Ontology,apical plasma membraneL>sp|Q16181|SEPT7_HUMAN Septin-7 OS=Homo sapiens OX=9606 GN=SEPTIN7 PE=1 SV=2P27348YWHAQ 1433T_HUMAN14-3-3 protein thetaBprotein targeting,small GTPase mediated signal transduction,substantia nigra development,negative regulation of ion transmembrane transport,negative regulation of transcription, DNA-templated,membrane organization,positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayprotein binding,protein C-terminus binding,protein domain specific binding,ion channel binding,protein N-terminus binding,14-3-3 protein bindingzcytoplasm,mitochondrion,cytosol,focal adhesion,membrane,cytoplasmic vesicle membrane,protein complex,extracellular exosomeV>sp|P27348|1433T_HUMAN 14-3-3 protein theta OS=Homo sapiens OX=9606 GN=YWHAQ PE=1 SV=1O76094SRP72 SRP72_HUMAN)Signal recognition particle subunit SRP72SRP-dependent cotranslational protein targeting to membrane,SRP-dependent cotranslational protein targeting to membrane, translocation,response to drugNRNA binding,signal recognition particle binding,protein binding,7S RNA bindingZendoplasmic reticulum,signal recognition particle, endoplasmic reticulum targeting,cytosolk>sp|O76094|SRP72_HUMAN Signal recognition particle subunit SRP72 OS=Homo sapiens OX=9606 GN=SRP72 PE=1 SV=3P27361MAPK3 MK03_HUMAN"Mitogen-activated protein kinase 3<MAPK cascade,activation of MAPK activity,MAPK import into nucleus,positive regulation of protein phosphorylation,transcription initiation from RNA polymerase I promoter,protein complex assembly,protein phosphorylation,apoptotic process,DNA damage induced protein phosphorylation,cell cycle,axon guidance,fibroblast growth factor receptor signaling pathway,response to toxic substance,regulation of phosphatidylinositol 3-kinase signaling,viral process,phosphorylation,peptidyl-serine phosphorylation,sensory perception of pain,arachidonic acid metabolic process,platelet activation,regulation of ossification,BMP signaling pathway,thyroid gland development,positive regulation of cyclase activity,lipopolysaccharide-mediated signaling pathway,positive regulation of telomere maintenance via telomerase,regulation of stress-activated MAPK cascade,positive regulation of histone phosphorylation,positive regulation of histone acetylation,peptidyl-tyrosine autophosphorylation,Fc-epsilon receptor signaling pathway,Fc-gamma receptor signaling pathway involved in phagocytosis,outer ear morphogenesis,response to exogenous dsRNA,positive regulation of translation,positive regulation of transcription from RNA polymerase II promoter,thymus development,regulation of sequence-specific DNA binding transcription factor activity,cartilage development,regulation of cytoskeleton organization,positive regulation of telomerase activity,Bergmann glial cell differentiation,face development,JAK-STAT cascade involved in growth hormone signaling pathway,lung morphogenesis,trachea formation,cardiac neural crest cell development involved in heart development,ERK1 and ERK2 cascade,positive regulation of ERK1 and ERK2 cascade,interleukin-1-mediated signaling pathway,response to epidermal growth factor,cellular response to mechanical stimulus,caveolin-mediated endocytosis,regulation of Golgi inheritance,regulation of cellular response to heat,positive regulation of telomere capping,positive regulation of xenophagy,regulation of early endosome to late endosome transport,negative regulation of apolipoprotein bindingphosphotyrosine binding,protein serine/threonine kinase activity,MAP kinase activity,protein binding,ATP binding,kinase activity,phosphatase binding,scaffold protein bindingnucleus,nuclear envelope,nucleoplasm,mitochondrion,early endosome,late endosome,Golgi apparatus,cytosol,cytoskeleton,caveola,focal adhesion,pseudopodium,protein complex,extracellular exosomec>sp|P27361|MK03_HUMAN Mitogen-activated protein kinase 3 OS=Homo sapiens OX=9606 GN=MAPK3 PE=1 SV=4P13612ITGA4 ITA4_HUMANIntegrin alpha-4cell-matrix adhesion involved in ameboidal cell migration,leukocyte cell-cell adhesion,cell-matrix adhesion,integrin-mediated signaling pathway,B cell differentiation,extracellular matrix organization,heterotypic cell-cell adhesion,substrate adhesion-dependent cell spread< ing,endodermal cell differentiation,receptor clustering,regulation of immune response,leukocyte migration,leukocyte tethering or rolling,diapedesis,cellular response to cytokine stimulus,negative regulation of protein homodimerization activity,import into cell,positive regulation of leukocyte tethering or rolling,clathrin-dependent extracellular exosome endocytosis,positive regulation of T cell migrationfibronectin binding,protein binding,coreceptor activity,metal ion binding,cell adhesion molecule binding,protein antigen binding,C-X3-C chemokine bindinghplasma membrane,focal adhesion,cell surface,membrane,integrin alpha4-beta7 complex,extracellular exosomeQ>sp|P13612|ITA4_HUMAN Integrin alpha-4 OS=Homo sapiens OX=9606 GN=ITGA4 PE=1 SV=3Q9Y224RTRAF RTRAF_HUMAN;RNA transcription, translation and transport factor proteintranscription, DNA-templated,tRNA splicing, via endonucleolytic cleavage and ligation,viral process,positive regulation of transcription from RNA polymerase II promoter,RNA transportTRNA polymerase II core binding,RNA binding,protein binding,identical protein bindingnucleus,nucleoplasm,cytoplasm,microtubule organizing center,cytosol,perinuclear region of cytoplasm,tRNA-splicing ligase complex}>sp|Q9Y224|RTRAF_HUMAN RNA transcription, translation and transport factor protein OS=Homo sapiens OX=9606 GN=RTRAF PE=1 SV=1P01008SERPINC1 ANT3_HUMANAntithrombin-IIIacute inflammatory response to antigenic stimulus,response to nutrient,lactation,blood coagulation,negative regulation of endopeptidase activity,regulation of blood coagulation, intrinsic pathway]protease binding,serine-type endopeptidase inhibitor activity,protein binding,heparin bindingT>sp|P01008|ANT3_HUMAN Antithrombin-III OS=Homo sapiens OX=9606 GN=SERPINC1 PE=1 SV=1Q9HDC9APMAP APMAP_HUMAN,Adipocyte plasma membrane-associated protein'biological_process,biosynthetic process5arylesterase activity,strictosidine synthase activity`endoplasmic reticulum,cell surface,membrane,integral component of membrane,extracellular exosomen>sp|Q9HDC9|APMAP_HUMAN Adipocyte plasma membrane-associated protein OS=Homo sapiens OX=9606 GN=APMAP PE=1 SV=2P40429RPL13A RL13A_HUMAN60S ribosomal protein L13aWnuclear-transcribed mRNA catabolic process, nonsense-mediated decay,rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,negative regulation of translation,viral transcription,cellular response to interferon-gamma,negative regulation of formation of translation preinitiation complex;RNA binding,mRNA binding,structural constituent of ribosomenucleus,nucleolus,cytoplasm,cytosol,focal adhesion,large ribosomal subunit,membrane,cytosolic large ribosomal subunit,intracellular ribonucleoprotein complex,GAIT complex]>sp|P40429|RL13A_HUMAN 60S ribosomal protein L13a OS=Homo sapiens OX=9606 GN=RPL13A PE=1 SV=2O75340PDCD6 PDCD6_HUMANProgrammed cell death protein 6angiogenesis,positive regulation of endothelial cell proliferation,proteolysis,intracellular protein transport,activation of cysteine-type endopeptidase activity involved in apoptotic process,positive regulation of endothelial cell migration,negative regulation of vascular endothelial growth factor receptor signaling pathway,negative regulation of TOR signaling,cellular response to heat,vascular endothelial growth factor receptor-2 signaling pathway,positive regulation of cysteine-type endopeptidase activity involved in apoptotic process,positive regulation of angiogenesis,response to calcium ion,negative regulation of protein kinase B signaling,apoptotic signaling pathwaycalcium-dependent cysteine-type endopeptidase activity,calcium ion binding,protein binding,identical protein binding,protein homodimerization activity,protein anchor,protein dimerization activity,calcium-dependent protein binding,binding, bridgingnucleus,cytoplasm,endosome,endoplasmic reticulum,endoplasmic reticulum membrane,cytoplasmic vesicle,nuclear membrane,extracellular exosome,endoplasmic reticulum exit sitea>sp|O75340|PDCD6_HUMAN Programmed cell death protein 6 OS=Homo sapiens OX=9606 GN=PDCD6 PE=1 SV=1P22234PAICS PUR6_HUMANMultifunctional protein ADE2'de novo' IMP biosynthetic process,purine nucleobase biosynthetic process,purine ribonucleoside monophosphate biosynthetic processphosphoribosylaminoimidazole carboxylase activity,phosphoribosylaminoimidazolesuccinocarboxamide synthase activity,protein binding,ATP binding,identical protein binding,cadherin binding]>sp|P22234|PUR6_HUMAN Multifunctional protein ADE2 OS=Homo sapiens OX=9606 GN=PAICS PE=1 SV=3O75718CRTAP CRTAP_HUMANCartilage-associated proteinspermatogenesis,peptidyl-proline hydroxylation to 3-hydroxy-L-proline,protein stabilization,chaperone-mediated protein folding,negative regulation of post-translational protein modificationprotein complex bindingproteinaceous extracellular matrix,extracellular space,endoplasmic reticulum,endoplasmic reticulum lumen,macromolecular complex^>sp|O75718|CRTAP_HUMAN Cartilage-associated protein OS=Homo sapiens OX=9606 GN=CRTAP PE=1 SV=1P21964COMT COMT_HUMANCatechol O-methyltransferaseZfemale pregnancy,learning,short-term memory,estrogen metabolic process,response to organic cyclic compound,cellular response to phosphate starvation,methylation,response to lipopolysaccharide,developmental process,negative regulation of renal sodium excretion,neurotransmitter catabolic process,dopamine catabolic process,response to drug,negative regulation of dopamine metabolic process,response to pain,multicellular organismal reproductive process,negative regulation of smooth muscle cell proliferation,positive regulation of homocysteine metabolic process,regulation of sensory perception of painmagnesium ion binding,protein binding,methyltransferase activity,O-methyltransferase activity,catechol O-methyltransferase activity,Requires Ontologymitochondrion,cytosol,plasma membrane,membrane,integral component of membrane,axon,dendritic spine,cell body,postsynaptic membrane,extracellular exosome\>sp|P21964|COMT_HUMAN Catechol O-methyltransferase OS=Homo sapiens OX=9606 GN=COMT PE=1 SV=2P61160ACTR2 ARP2_HUMANActin-related protein 2Nmovement of cell or subcellular component,establishment or maintenance of cell polarity,associative learning,asymmetric cell division,meiotic chromosome movement towards spindle pole,cytosolic transport,meiotic cytokinesis,Arp2/3 complex-mediated actin nucleation,response to immobilization stress,cellular response to trichostatin A,Fc-gamma receptor signaling pathway involved in phagocytosis,neutrophil degranulation,response to ethanol,ephrin receptor signaling pathway,spindle localization,cilium morphogenesis,positive regulation of dendritic spine morphogenesis,membrane organizationIstructural constituent of cytoskeleton,ATP binding,actin filament bindingpodosome,extracellular region,cytoplasm,cytosol,Arp2/3 protein complex,focal adhesion,postsynaptic density,actin cytoskeleton,membrane,lamellipodium,actin cap,azurophil granule lumen,extracellular exosome,invadopodium,ficolin-1-rich granule lumenX>sp|P61160|ARP2_HUMAN Actin-related protein 2 OS=Homo sapiens OX=9606 GN=ACTR2 PE=1 SV=1P62906RPL10A RL10A_HUMAN60S ribosomal protein L10anuclear-transcribed mRNA catabolic process, nonsense-mediated decay,maturation of LSU-rRNA,rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,viral transcription,response to ethanol_nucleus,cytosol,focal adhesion,membrane,cytosolic large ribosomal subunit,extracellular exosome]>sp|P62906|RL10A_HUMAN 60S ribosomal protein L10a OS=Homo sapiens OX=9606 GN=RPL10A PE=1 SV=2O95394PGM3 AGM1_HUMANPhosphoacetylglucosamine mutasecarbohydrate metabolic process,glucosamine metabolic process,UDP-N-acetylglucosamine biosynthetic process,protein N-linked glycosylation,protein O-linked glycosylation,spermatogenesis,glucose 1-phosphate metabolic process,hemopoiesisZmagnesium ion binding,phosphoacetylglucosamine mutase activity,phosphoglucomutase activity< _>sp|O95394|AGM1_HUMAN Phosphoacetylglucosamine mutase OS=Homo sapiens OX=9606 GN=PGM3 PE=1 SV=1P43034PAFAH1B1 LIS1_HUMAN:Platelet-activating factor acetylhydrolase IB subunit betaG2/M transition of mitotic cell cycle,establishment of mitotic spindle orientation,microtubule cytoskeleton organization,ameboidal-type cell migration,acrosome assembly,neuron migration,positive regulation of cytokine-mediated signaling pathway,microtubule-based process,sister chromatid cohesion,mitotic nuclear division,nuclear migration,chemical synaptic transmission,germ cell development,neuroblast proliferation,learning or memory,retrograde axonal transport,adult locomotory behavior,protein secretion,negative regulation of neuron projection development,lipid catabolic process,stem cell division,transmission of nerve impulse,corpus callosum morphogenesis,hippocampus development,layer formation in cerebral cortex,cerebral cortex neuron differentiation,cerebral cortex development,actin cytoskeleton organization,microtubule organizing center organization,osteoclast development,positive regulation of embryonic development,establishment of planar polarity of embryonic epithelium,regulation of GTPase activity,cortical microtubule organization,positive regulation of axon extension,positive regulation of mitotic cell cycle,negative regulation of JNK cascade,platelet activating factor metabolic process,vesicle transport along microtubule,brain morphogenesis,neuromuscular process controlling balance,nuclear envelope disassembly,establishment of centrosome localization,maintenance of centrosome location,auditory receptor cell development,positive regulation of dendritic spine morphogenesis,regulation of microtubule cytoskeleton organization,cochlea development,microtubule cytoskeleton organization involved in establishment of planar polarity,ciliary basal body docking,regulation of microtubule motor activityphospholipase A2 activity,protein binding,microtubule binding,heparin binding,dynactin binding,protein homodimerization activity,phospholipase binding,dynein intermediate chain binding,phosphoprotein binding,dynein complex bindingastral microtubule,kinetochore,nuclear envelope,centrosome,cytosol,kinesin complex,microtubule associated complex,cell cortex,growth cone,motile cilium,nuclear membrane,stereocilium,neuronal cell body,perinuclear region of cytoplasm,extracellular exosome,axon cytoplasm,cell leading edge~>sp|P43034|LIS1_HUMAN Platelet-activating factor acetylhydrolase IB subunit beta OS=Homo sapiens OX=9606 GN=PAFAH1B1 PE=1 SV=2P31943HNRNPH1 HNRH1_HUMAN)Heterogeneous nuclear ribonucleoprotein HmRNA splicing, via spliceosome,RNA processing,fibroblast growth factor receptor signaling pathway,gene expression,regulation of RNA splicingBnucleotide binding,RNA binding,protein binding,poly(U) RNA bindingAnucleus,nucleoplasm,cytosol,membrane,catalytic step 2 spliceosomem>sp|P31943|HNRH1_HUMAN Heterogeneous nuclear ribonucleoprotein H OS=Homo sapiens OX=9606 GN=HNRNPH1 PE=1 SV=4P26373RPL13 RL13_HUMAN60S ribosomal protein L13Mnucleus,cytosol,membrane,cytosolic large ribosomal subunit,cytosolic ribosomeZ>sp|P26373|RL13_HUMAN 60S ribosomal protein L13 OS=Homo sapiens OX=9606 GN=RPL13 PE=1 SV=4Q9Y625GPC6 GPC6_HUMAN Glypican-6retinoid metabolic process,glycosaminoglycan biosynthetic process,glycosaminoglycan catabolic process,cell migration,glycosaminoglycan metabolic process,Wnt signaling pathway, planar cell polarity pathwayxheparan sulfate proteoglycan binding,coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathwayproteinaceous extracellular matrix,extracellular space,nucleus,Golgi lumen,plasma membrane,integral component of plasma membrane,anchored component of membrane,lysosomal lumenJ>sp|Q9Y625|GPC6_HUMAN Glypican-6 OS=Homo sapiens OX=9606 GN=GPC6 PE=1 SV=1P07203GPX1 GPX1_HUMANGlutathione peroxidase 1$response to reactive oxygen species,temperature homeostasis,endothelial cell development,negative regulation of inflammatory response to antigenic stimulus,purine nucleotide catabolic process,triglyceride metabolic process,glutathione metabolic process,sensory perception of sound,intrinsic apoptotic signaling pathway in response to oxidative stress,response to xenobiotic stimulus,response to symbiotic bacterium,UV protection,response to selenium ion,response to gamma radiation,protein oxidation,lipoxygenase pathway,response to hydroperoxide,regulation of mammary gland epithelial cell proliferation,cellular response to oxidative stress,regulation of gene expression, epigenetic,vasodilation,response to hydrogen peroxide,hydrogen peroxide catabolic process,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process,skeletal muscle tissue regeneration,regulation of neuron apoptotic process,blood vessel endothelial cell migration,fat cell differentiation,cell redox homeostasis,skeletal muscle fiber development,myoblast proliferation,interaction with symbiont,positive regulation of protein kinase B signaling,heart contraction,angiogenesis involved in wound healing,regulation of proteasomal protein catabolic process,negative regulation of release of cytochrome c from mitochondria,cellular oxidant detoxification,negative regulation of extrinsic apoptotic signaling pathway via death domain receptors,negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway,positive regulation of fibril organization2glutathione peroxidase activity,SH3 domain bindingTcytoplasm,mitochondrion,mitochondrial matrix,cytosol,extracellular exosome,Lewy bodyX>sp|P07203|GPX1_HUMAN Glutathione peroxidase 1 OS=Homo sapiens OX=9606 GN=GPX1 PE=1 SV=4P00966ASS1 ASSY_HUMANArgininosuccinate synthase"urea cycle,citrulline metabolic process,argininosuccinate metabolic process,arginine biosynthetic process,aspartate metabolic process,positive regulation of nitric oxide biosynthetic process,cellular response to laminar fluid shear stress,negative regulation of leukocyte cell-cell adhesionxRNA binding,argininosuccinate synthase activity,protein binding,ATP binding,amino acid binding,identical protein bindingCcytoplasm,mitochondrion,cytosol,myelin sheath,extracellular exosomeZ>sp|P00966|ASSY_HUMAN Argininosuccinate synthase OS=Homo sapiens OX=9606 GN=ASS1 PE=1 SV=2P62263RPS14 RS14_HUMAN40S ribosomal protein S14ribosomal small subunit assembly,negative regulation of transcription from RNA polymerase II promoter,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA),rRNA processing,translation,translational initiation,regulation of translation,SRP-dependent cotranslational protein targeting to membrane,viral transcription,erythrocyte differentiation,maturation of SSU-rRNARNA binding,structural constituent of ribosome,protein binding,translation regulator activity,mRNA 5'-UTR binding,small ribosomal subunit rRNA bindingnucleoplasm,nucleolus,mitochondrion,cytosol,focal adhesion,membrane,cytosolic small ribosomal subunit,extracellular matrix,extracellular exosomeZ>sp|P62263|RS14_HUMAN 40S ribosomal protein S14 OS=Homo sapiens OX=9606 GN=RPS14 PE=1 SV=3P27701CD82 CD82_HUMAN CD82 antigen'cell surface receptor signaling pathwayKplasma membrane,integral component of plasma membrane,extracellular exosomeL>sp|P27701|CD82_HUMAN CD82 antigen OS=Homo sapiens OX=9606 GN=CD82 PE=1 SV=1P00749PLAU UROK_HUMAN$Urokinase-type plasminogen activatorresponse to hypoxia,proteolysis,chemotaxis,signal transduction,blood coagulation,regulation of receptor activity,smooth muscle cell migration,regulation of smooth muscle cell migration,positive regulation of cell migration,regulation of cell adhesion mediated by integrin,regulation of cell proliferation,fibrinolysis,neutrophil degranulation,regulation of wound healing,regulation of smooth muscle cell-matrix adhesion2serine-type endopeptidase activity,protein bindingextracellular region,extracellular space,plasma membrane,focal adhesion,cell surface,specific granule membrane,e< xtracellular exosome,tertiary granule membraned>sp|P00749|UROK_HUMAN Urokinase-type plasminogen activator OS=Homo sapiens OX=9606 GN=PLAU PE=1 SV=2P18085ARF4 ARF4_HUMANADP-ribosylation factor 4protein ADP-ribosylation,ER to Golgi vesicle-mediated transport,retrograde vesicle-mediated transport, Golgi to ER,epidermal growth factor receptor signaling pathway,small GTPase mediated signal transduction,brain development,learning,protein transport,cell migration,activation of phospholipase D activity,negative regulation of apoptotic process,positive regulation of GTPase activity,apical protein localization,establishment or maintenance of epithelial cell apical/basal polarity,positive regulation of transcription from RNA polymerase II promoter,response to axon injury,dendritic spine development,protein localization to cilium,regulation of reactive oxygen species metabolic processGTPase activity,ARF guanyl-nucleotide exchange factor activity,epidermal growth factor receptor binding,protein binding,GTP bindingkGolgi apparatus,cytosol,membrane,extracellular matrix,ruffle membrane,dendritic spine,extracellular exosomeY>sp|P18085|ARF4_HUMAN ADP-ribosylation factor 4 OS=Homo sapiens OX=9606 GN=ARF4 PE=1 SV=3O75915ARL6IP5 PRAF3_HUMANPRA1 family protein 3xnegative regulation of L-glutamate transport,intrinsic apoptotic signaling pathway in response to oxidative stress,negative regulation of mitochondrial membrane potential,L-glutamate transport,positive regulation of stress-activated MAPK cascade,positive regulation of apoptotic process,positive regulation of cysteine-type endopeptidase activity involved in apoptotic processyendoplasmic reticulum membrane,cytoskeleton,plasma membrane,membrane,integral component of membrane,extracellular exosomeY>sp|O75915|PRAF3_HUMAN PRA1 family protein 3 OS=Homo sapiens OX=9606 GN=ARL6IP5 PE=1 SV=1P06748NPM1 NPM_HUMAN Nucleophosmin&DNA repair,nucleosome assembly,regulation of transcription from RNA polymerase II promoter,intracellular protein transport,nucleocytoplasmic transport,response to stress,DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest,centrosome cycle,signal transduction,cell aging,protein localization,positive regulation of cell proliferation,negative regulation of cell proliferation,negative regulation of centrosome duplication,viral process,regulation of endodeoxyribonuclease activity,CENP-A containing nucleosome assembly,ribosome assembly,negative regulation of apoptotic process,negative regulation of protein kinase activity by regulation of protein phosphorylation,positive regulation of translation,positive regulation of transcription, DNA-templated,regulation of centriole replication,positive regulation of NF-kappaB transcription factor activity,protein oligomerization,regulation of endoribonuclease activity,regulation of eIF2 alpha phosphorylation by dsRNA,positive regulation of cell cycle G2/M phase transitionLtranscription coactivator activity,RNA binding,protein kinase inhibitor activity,protein binding,protein kinase binding,Tat protein binding,histone binding,protein homodimerization activity,ribosomal large subunit binding,ribosomal small subunit binding,protein heterodimerization activity,NF-kappaB binding,unfolded protein bindingnucleus,nucleoplasm,nucleolus,cytoplasm,centrosome,cytosol,focal adhesion,membrane,intracellular ribonucleoprotein complex,spindle pole centrosomeL>sp|P06748|NPM_HUMAN Nucleophosmin OS=Homo sapiens OX=9606 GN=NPM1 PE=1 SV=2P55209NAP1L1 NP1L1_HUMAN$Nucleosome assembly protein 1-like 1MDNA replication,nucleosome assembly,positive regulation of cell proliferationnucleus,membrane,melanosomeg>sp|P55209|NP1L1_HUMAN Nucleosome assembly protein 1-like 1 OS=Homo sapiens OX=9606 GN=NAP1L1 PE=1 SV=1Q8IV08PLD3 PLD3_HUMAN5'-3' exonuclease PLD3lipid catabolic processiphospholipase D activity,protein binding,N-acylphosphatidylethanolamine-specific phospholipase D activitySendoplasmic reticulum membrane,integral component of membrane,extracellular exosomeV>sp|Q8IV08|PLD3_HUMAN 5'-3' exonuclease PLD3 OS=Homo sapiens OX=9606 GN=PLD3 PE=1 SV=1Q92841DDX17 DDX17_HUMAN)Probable ATP-dependent RNA helicase DDX17Gregulation of alternative mRNA splicing, via spliceosome,transcription, DNA-templated,RNA processing,RNA secondary structure unwinding,positive regulation of intracellular estrogen receptor signaling pathway,positive regulation of transcription from RNA polymerase II promoter,regulation of skeletal muscle cell differentiationtranscription coactivator activity,RNA binding,RNA helicase activity,ATP-dependent RNA helicase activity,protein binding,ATP binding,RNA-dependent ATPase activity,estrogen receptor binding(nucleus,nucleolus,membrane,nuclear speckk>sp|Q92841|DDX17_HUMAN Probable ATP-dependent RNA helicase DDX17 OS=Homo sapiens OX=9606 GN=DDX17 PE=1 SV=2P38919EIF4A3 IF4A3_HUMAN#Eukaryotic initiation factor 4A-IIInuclear-transcribed mRNA catabolic process, nonsense-mediated decay,nuclear-transcribed mRNA poly(A) tail shortening,mRNA splicing, via spliceosome,rRNA processing,termination of RNA polymerase II transcription,RNA export from nucleus,mRNA export from nucleus,associative learning,RNA splicing,RNA secondary structure unwinding,response to organic cyclic compound,negative regulation of translation,mRNA 3'-end processing,exploration behavior,positive regulation of translation,positive regulation of transcription from RNA polymerase II promoter,positive regulation of mRNA splicing, via spliceosome,embryonic cranial skeleton morphogenesis,cellular response to selenite ion,negative regulation of excitatory postsynaptic potential,negative regulation of selenocysteine incorporation,negative regulation of selenocysteine insertion sequence binding,cellular response to brain-derived neurotrophic factor stimulusRNA binding,mRNA binding,ATP-dependent RNA helicase activity,protein binding,ATP binding,poly(A) binding,selenocysteine insertion sequence binding,RNA stem-loop binding,ribonucleoprotein complex bindingnucleoplasm,cytoplasm,cytosol,membrane,nuclear speck,dendrite,exon-exon junction complex,neuronal cell body,catalytic step 2 spliceosomef>sp|P38919|IF4A3_HUMAN Eukaryotic initiation factor 4A-III OS=Homo sapiens OX=9606 GN=EIF4A3 PE=1 SV=4O43592XPOT XPOT_HUMAN Exportin-T4tRNA export from nucleus,tRNA re-export from nucleusqtRNA binding,protein binding,Ran GTPase binding,nucleobase-containing compound transmembrane transporter activity9nucleoplasm,cytoplasm,cytosol,nuclear matrix,nuclear poreJ>sp|O43592|XPOT_HUMAN Exportin-T OS=Homo sapiens OX=9606 GN=XPOT PE=1 SV=2Q6PGP7TTC37 TTC37_HUMAN#Tetratricopeptide repeat protein 37cexonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decayTnucleus,nucleoplasm,cytoplasm,cytosol,transcriptionally active chromatin,Ski complexe>sp|Q6PGP7|TTC37_HUMAN Tetratricopeptide repeat protein 37 OS=Homo sapiens OX=9606 GN=TTC37 PE=1 SV=1O75643SNRNP200 U520_HUMAN3U5 small nuclear ribonucleoprotein 200 kDa helicaseccis assembly of pre-catalytic spliceosome,mRNA splicing, via spliceosome,osteoblast differentiationRNA binding,ATP-dependent RNA helicase activity,protein binding,ATP binding,ATP-dependent helicase activity,identical protein bindingWnucleus,nucleoplasm,spliceosomal complex,U5 snRNP,membrane,catalytic step 2 spliceosomew>sp|O75643|U520_HUMAN U5 small nuclear ribonucleoprotein 200 kDa helicase OS=Homo sapiens OX=9606 GN=SNRNP200 PE=1 SV=2Q13509TUBB3 TBB3_HUMANTubulin beta-3 chainZcytoskeleton organization,microtubule-based process,mitotic nuclear division,axon guidancebGTPase activity,structural constituent of cytoskeleton,protein binding,GTP binding,peptide binding|nucleus,cytoplasm,microtubule,microtubule cytoskeleton,axon,dendrite,neuronal cell body,extracellular exosome,cell peripheryU>sp|Q13509|TBB3_HUMAN Tubulin beta-3 chain OS=Homo sapiens OX=9606 GN=TUBB3 PE=1 SV=2O00154ACOT7 BACH_HUMAN-Cytosolic acyl coenzyme A thioester hydrolasecoenzyme A biosynthetic process,long< -chain fatty-acyl-CoA biosynthetic process,medium-chain fatty-acyl-CoA catabolic process,long-chain fatty-acyl-CoA catabolic process,medium-chain fatty acid biosynthetic process,palmitic acid biosynthetic processfatty-acyl-CoA binding,protein binding,palmitoyl-CoA hydrolase activity,long-chain fatty acyl-CoA binding,protein homodimerization activity,acyl-CoA hydrolase activity,carboxylic ester hydrolase activity,Requires Ontology7nucleoplasm,mitochondrion,cytosol,extracellular exosomen>sp|O00154|BACH_HUMAN Cytosolic acyl coenzyme A thioester hydrolase OS=Homo sapiens OX=9606 GN=ACOT7 PE=1 SV=3O14495PLPP3 PLPP3_HUMANPhospholipid phosphatase 3Vblood vessel development,gastrulation with mouth forming second,negative regulation of protein phosphorylation,protein dephosphorylation,lipid metabolic process,phospholipid metabolic process,germ cell migration,regulation of Wnt signaling pathway,sphingolipid biosynthetic process,homotypic cell-cell adhesion,canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration,canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion,canonical Wnt signaling pathway involved in positive regulation of wound healing,phospholipid dephosphorylation,positive regulation of peptidyl-tyrosine phosphorylation,protein stabilization,positive regulation of sequence-specific DNA binding transcription factor activity,Bergmann glial cell differentiation,regulation of sphingolipid mediated signaling pathwayphosphoprotein phosphatase activity,integrin binding,protein binding,phosphatidate phosphatase activity,sphingosine-1-phosphate phosphatase activity,lipid phosphatase activityvGolgi apparatus,plasma membrane,integral component of plasma membrane,adherens junction,membrane,extracellular exosome\>sp|O14495|PLPP3_HUMAN Phospholipid phosphatase 3 OS=Homo sapiens OX=9606 GN=PLPP3 PE=1 SV=1Q13045FLII FLII_HUMANProtein flightless-1 homologtranscription, DNA-templated,regulation of transcription, DNA-templated,multicellular organism development,actin cytoskeleton organization,actin filament severingMnucleoplasm,microtubule organizing center,cytosol,brush border,focal adhesion\>sp|Q13045|FLII_HUMAN Protein flightless-1 homolog OS=Homo sapiens OX=9606 GN=FLII PE=1 SV=2Q9BTU6PI4K2A P4K2A_HUMAN*Phosphatidylinositol 4-kinase type 2-alphawphosphatidylinositol biosynthetic process,Golgi organization,endosome organization,phosphatidylinositol phosphorylationwmagnesium ion binding,1-phosphatidylinositol 4-kinase activity,protein binding,ATP binding,AP-3 adaptor complex bindingVmitochondrion,lysosomal membrane,endosome,trans-Golgi network,cytosol,plasma membrane,integral component of plasma membrane,membrane,cell junction,dendrite,intrinsic component of membrane,cytoplasmic vesicle,growing cell tip,presynaptic membrane,neuron projection,neuronal cell body,host cell presynaptic membrane,membrane raft,BLOC-1 complexm>sp|Q9BTU6|P4K2A_HUMAN Phosphatidylinositol 4-kinase type 2-alpha OS=Homo sapiens OX=9606 GN=PI4K2A PE=1 SV=1Q92542NCSTN NICA_HUMAN Nicastrinmyeloid cell homeostasis,proteolysis,membrane protein ectodomain proteolysis,Notch signaling pathway,Notch receptor processing,protein processing,membrane protein intracellular domain proteolysis,beta-amyloid formation,T cell proliferation,amyloid precursor protein metabolic process,amyloid precursor protein catabolic process,positive regulation of apoptotic process,positive regulation of catalytic activity,neutrophil degranulation,ephrin receptor signaling pathway,epithelial cell proliferationlysosomal membrane,endoplasmic reticulum,Golgi apparatus,plasma membrane,integral component of plasma membrane,focal adhesion,membrane,integral component of membrane,azurophil granule membrane,melanosome,extracellular exosome,gamma-secretase complexJ>sp|Q92542|NICA_HUMAN Nicastrin OS=Homo sapiens OX=9606 GN=NCSTN PE=1 SV=2P20073ANXA7 ANXA7_HUMAN Annexin A77cellular calcium ion homeostasis,autophagy,hemostasis,cell proliferation,regulation of cell shape,response to salt stress,cellular water homeostasis,negative regulation of gene expression,response to organic cyclic compound,epithelial cell differentiation,social behavior,response to calcium ion,membrane fusionRNA binding,integrin binding,calcium ion binding,protein binding,calcium-dependent phospholipid binding,calcium-dependent protein bindingnucleus,nuclear envelope,endoplasmic reticulum membrane,cytosol,plasma membrane,membrane,extracellular exosome,chromaffin granule membraneL>sp|P20073|ANXA7_HUMAN Annexin A7 OS=Homo sapiens OX=9606 GN=ANXA7 PE=1 SV=3Q15262PTPRK PTPRK_HUMAN0Receptor-type tyrosine-protein phosphatase kappa!protein dephosphorylation,cell adhesion,signal transduction,transforming growth factor beta receptor signaling pathway,negative regulation of cell proliferation,negative regulation of keratinocyte proliferation,cell migration,negative regulation of cell migration,neuron projection development,protein localization to cell surface,cellular response to reactive oxygen species,cellular response to UV,peptidyl-tyrosine dephosphorylation,negative regulation of cell cycle,negative regulation of transcription, DNA-templated,focal adhesion assemblyprotein tyrosine phosphatase activity,transmembrane receptor protein tyrosine phosphatase activity,protein binding,beta-catenin binding,protein kinase binding,gamma-catenin bindingphotoreceptor outer segment,plasma membrane,integral component of plasma membrane,cell-cell junction,adherens junction,cell surface,integral component of membrane,cell junction,axon,dendrite,leading edge membrane,neuronal cell body,intracellular membrane-bounded organeller>sp|Q15262|PTPRK_HUMAN Receptor-type tyrosine-protein phosphatase kappa OS=Homo sapiens OX=9606 GN=PTPRK PE=1 SV=2Q5SSJ5HP1BP3 HP1B3_HUMAN+Heterochromatin protein 1-binding protein 3nucleosome assembly,regulation of transcription, DNA-templated,regulation of cell proliferation,heterochromatin organization,cellular response to hypoxia,regulation of nucleus size.DNA binding,protein binding,nucleosome binding+nucleosome,nucleus,chromosome,nuclear speckn>sp|Q5SSJ5|HP1B3_HUMAN Heterochromatin protein 1-binding protein 3 OS=Homo sapiens OX=9606 GN=HP1BP3 PE=1 SV=1O95477ABCA1 ABCA1_HUMAN&Phospholipid-transporting ATPase ABCA1rpeptide secretion,protein lipidation,phagocytosis, engulfment,lysosome organization,G-protein coupled receptor signaling pathway,response to nutrient,cholesterol metabolic process,negative regulation of macrophage derived foam cell differentiation,positive regulation of cholesterol efflux,negative regulation of cholesterol storage,aminophospholipid transport,endosomal transport,positive regulation of cAMP biosynthetic process,intracellular cholesterol transport,regulation of Cdc42 protein signal transduction,cholesterol efflux,phospholipid efflux,high-density lipoprotein particle assembly,response to laminar fluid shear stress,apolipoprotein A-I-mediated signaling pathway,lipoprotein metabolic process,response to drug,cholesterol homeostasis,reverse cholesterol transport,phospholipid translocation,interleukin-1 beta secretion,phospholipid homeostasis,response to low-density lipoprotein particle,platelet dense granule organization,cellular response to lipopolysaccharide,cellular response to retinoic acid,cellular response to cholesterol,regulation of high-density lipoprotein particle assembly,anion transmembrane transportreceptor binding,protein binding,ATP binding,phospholipid binding,phospholipid transporter activity,anion transmembrane transporter activity,cholesterol binding,ATPase activity,cholesterol transporter activity,syntaxin binding,small GTPase binding,apolipoprotein binding,apolipoprotein A-I binding,apolipoprotein A-I receptor activity,ATPase activity, coupled to transmembrane movement of substances,ATPase binding,phosphatidylcholine-translocating ATPase activity,phosphatidylserine-translocating ATPase activity#endoplasmic reticulum membrane,Golgi apparatus,plasma membrane,integral component of plasma membrane,external side of plasma membr< ane,endocytic vesicle,high-density lipoprotein particle,intracellular membrane-bounded organelle,membrane raft,phagocytic vesicle,perinuclear region of cytoplasmh>sp|O95477|ABCA1_HUMAN Phospholipid-transporting ATPase ABCA1 OS=Homo sapiens OX=9606 GN=ABCA1 PE=1 SV=3P43121MCAM MUC18_HUMANCell surface glycoprotein MUC18angiogenesis,glomerular filtration,cell adhesion,anatomical structure morphogenesis,positive regulation of cell migration,vascular wound healingzextracellular space,nucleus,plasma membrane,focal adhesion,external side of plasma membrane,integral component of membrane`>sp|P43121|MUC18_HUMAN Cell surface glycoprotein MUC18 OS=Homo sapiens OX=9606 GN=MCAM PE=1 SV=2P63104YWHAZ 1433Z_HUMAN14-3-3 protein zeta/delta7protein targeting,signal transduction,platelet activation,negative regulation of apoptotic process,regulation of mRNA stability,establishment of Golgi localization,membrane organization,Golgi reassembly,positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayRNA binding,protein binding,transcription factor binding,protein kinase binding,protein domain specific binding,ubiquitin protein ligase binding,identical protein binding,cadherin bindingextracellular space,nucleus,nucleoplasm,cytoplasm,mitochondrion,cytosol,focal adhesion,cytoplasmic vesicle membrane,melanosome,extracellular exosome,blood microparticle[>sp|P63104|1433Z_HUMAN 14-3-3 protein zeta/delta OS=Homo sapiens OX=9606 GN=YWHAZ PE=1 SV=1Q96AY3FKBP10 FKB10_HUMAN*Peptidyl-prolyl cis-trans isomerase FKBP10Hprotein peptidyl-prolyl isomerization,chaperone-mediated protein foldingNpeptidyl-prolyl cis-trans isomerase activity,calcium ion binding,FK506 binding%cytoplasm,endoplasmic reticulum lumenm>sp|Q96AY3|FKB10_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP10 OS=Homo sapiens OX=9606 GN=FKBP10 PE=1 SV=1P02792FTL FRIL_HUMANFerritin light chainiron ion transport,cellular iron ion homeostasis,intracellular sequestering of iron ion,neutrophil degranulation,iron ion homeostasisNiron ion binding,protein binding,ferric iron binding,identical protein bindingextracellular region,cytosol,intracellular ferritin complex,membrane,azurophil granule lumen,autolysosome,extracellular exosomeS>sp|P02792|FRIL_HUMAN Ferritin light chain OS=Homo sapiens OX=9606 GN=FTL PE=1 SV=2P15531NME1 NDKA_HUMANNucleoside diphosphate kinase Anucleoside diphosphate phosphorylation,GTP biosynthetic process,UTP biosynthetic process,CTP biosynthetic process,DNA metabolic process,endocytosis,nervous system development,negative regulation of cell proliferation,nucleobase-containing small molecule interconversion,cell differentiation,regulation of apoptotic process,positive regulation of DNA binding,positive regulation of epithelial cell proliferationmagnesium ion binding,RNA binding,deoxyribonuclease activity,nucleoside diphosphate kinase activity,protein binding,ATP binding,GTP binding,identical protein binding,ribosomal small subunit bindingHnucleus,cytoplasm,cytosol,membrane,ruffle membrane,extracellular exosome_>sp|P15531|NDKA_HUMAN Nucleoside diphosphate kinase A OS=Homo sapiens OX=9606 GN=NME1 PE=1 SV=1P47755CAPZA2 CAZA2_HUMAN'F-actin-capping protein subunit alpha-2protein complex assembly,movement of cell or subcellular component,blood coagulation,innate immune response,barbed-end actin filament capping actin bindingextracellular region,cytosol,brush border,F-actin capping protein complex,actin cytoskeleton,membrane,cortical cytoskeleton,extracellular exosomej>sp|P47755|CAZA2_HUMAN F-actin-capping protein subunit alpha-2 OS=Homo sapiens OX=9606 GN=CAPZA2 PE=1 SV=3P84095RHOG RHOG_HUMAN$Rho-related GTP-binding protein RhoGRho protein signal transduction,positive regulation of cell proliferation,Rac protein signal transduction,actin cytoskeleton organization,platelet activation,neutrophil degranulation,positive regulation of transcription, DNA-templated,regulation of small GTPase mediated signal transduction,cell chemotaxis,positive regulation of establishment of protein localization to plasma membrane,activation of GTPase activity,regulation of ruffle assemblyvendoplasmic reticulum membrane,cytosol,plasma membrane,focal adhesion,secretory granule membrane,extracellular exosomed>sp|P84095|RHOG_HUMAN Rho-related GTP-binding protein RhoG OS=Homo sapiens OX=9606 GN=RHOG PE=1 SV=1P12273PIP PIP_HUMANProlactin-inducible proteindetection of chemical stimulus involved in sensory perception of bitter taste,retina homeostasis,regulation of immune system process,proteolysis,positive regulation of gene expression,transmembrane transport,negative regulation of T cell apoptotic processglycoprotein binding,actin binding,aspartic-type endopeptidase activity,protein binding,IgG binding,protein dimerization activity]extracellular region,extracellular space,nucleus,apical plasma membrane,extracellular exosomeY>sp|P12273|PIP_HUMAN Prolactin-inducible protein OS=Homo sapiens OX=9606 GN=PIP PE=1 SV=1O15173PGRMC2 PGRC2_HUMAN5Membrane-associated progesterone receptor component 2*steroid hormone mediated signaling pathwayNsteroid hormone receptor activity,steroid binding,protein binding,heme binding8nuclear envelope,membrane,integral component of membranex>sp|O15173|PGRC2_HUMAN Membrane-associated progesterone receptor component 2 OS=Homo sapiens OX=9606 GN=PGRMC2 PE=1 SV=1Q6EMK4VASN VASN_HUMANVasorinnegative regulation of epithelial to mesenchymal transition,negative regulation of transforming growth factor beta receptor signaling pathway,cellular response to hypoxia,cellular response to redox stateHprotein binding,cadherin binding,transforming growth factor beta bindingextracellular space,mitochondrion,lysosomal membrane,plasma membrane,cell surface,integral component of membrane,extracellular exosomeG>sp|Q6EMK4|VASN_HUMAN Vasorin OS=Homo sapiens OX=9606 GN=VASN PE=1 SV=1P60033CD81 CD81_HUMAN CD81 antigenactivation of MAPK activity,cell surface receptor signaling pathway,protein localization,cell proliferation,positive regulation of cell proliferation,positive regulation of B cell proliferation,receptor internalization,regulation of protein stability,positive regulation of 1-phosphatidylinositol 4-kinase activity,positive regulation of transcription from RNA polymerase II promoter,viral entry into host cell,receptor-mediated virion attachment to host cell,positive regulation of peptidyl-tyrosine phosphorylation,regulation of immune response,protein localization to lysosome,cellular response to low-density lipoprotein particle stimulus,positive regulation of protein catabolic process in the vacuole,regulation of cell motilityQprotein binding,MHC class II protein complex binding,transferrin receptor bindingimmunological synapse,plasma membrane,integral component of plasma membrane,focal adhesion,membrane,vesicle,extracellular exosomeL>sp|P60033|CD81_HUMAN CD81 antigen OS=Homo sapiens OX=9606 GN=CD81 PE=1 SV=1O60443GSDME GSDME_HUMAN Gasdermin-Esensory perception of sound,negative regulation of cell proliferation,programmed cell death,inner ear receptor cell differentiation,positive regulation of intrinsic apoptotic signaling pathwaycytosol,plasma membraneM>sp|O60443|GSDME_HUMAN Gasdermin-E OS=Homo sapiens OX=9606 GN=GSDME PE=1 SV=2Q03135CAV1 CAV1_HUMAN Caveolin-1negative regulation of transcription from RNA polymerase II promoter,MAPK cascade,inactivation of MAPK activity,angiogenesis,vasculogenesis,response to hypoxia,negative regulation of endothelial cell proliferation,negative regulation of cytokine-mediated signaling pathway,response to ischemia,regulation of the force of heart contraction by chemical signal,triglyceride metabolic process,calcium ion transport,cellular calcium ion homeostasis,regulation of smooth muscle contraction,skeletal muscle tissue development,lactation,protein localization,response to bacterium,positive regulation of calcium ion transport into cytosol,posttranscriptional regulation of gene expression,positive regulation of gene expre< ssion,positive regulation of peptidase activity,vesicle organization,receptor-mediated endocytosis of virus by host cell,regulation of fatty acid metabolic process,lipid storage,regulation of blood coagulation,cholesterol transport,negative regulation of transforming growth factor beta receptor signaling pathway,negative regulation of epithelial cell differentiation,mammary gland development,T cell costimulation,negative regulation of protein ubiquitination,positive regulation of protein ubiquitination,receptor internalization,negative regulation of protein binding,positive regulation of protein binding,maintenance of protein location in cell,response to progesterone,negative regulation of peptidyl-serine phosphorylation,positive regulation of peptidyl-serine phosphorylation,nitric oxide homeostasis,positive regulation of toll-like receptor 3 signaling pathway,vasoconstriction,negative regulation of tyrosine phosphorylation of Stat5 protein,cholesterol homeostasis,positive regulation of catalytic activity,negative regulation of MAPK cascade,response to estrogen,protein localization to plasma membrane raft,negative regulation of nitric oxide biosynthetic process,positive regulation of vasoconstriction,negative regulation of JAK-STAT cascade,negative regulation of pinocytosis,leukocyte migration,regulation of nitric-oxide synthase activity,negative regulation of nitric-oxide synthase activity,protein homooligomerization,regulation of cytosolic calcium ion concentration,response to calcium ion,membrane depolarization,regulation of peptidase activity,calcium ion homeostasis,mammary gland involution,positive regulation of cell adhesion molecule production,negative regulation of necroptotic process,negative regulation of protein tyrosine kinase activity,caveola assembly,cellular response to exogenous dsRNA,cellular response to peptide hormone stimulus,cellular response to hyperoxia,cellular response to transforming growth factor beta stimulus,caveolin-mediated endocytosis,regulation of heart rate by cardiac conduction,angiotensin-activated signaling pathway involved in heart process,negative regulation of canonical Wnt signaling pathway,positive regulation of canonical Wnt signaling pathway,apoptotic signaling pathway,regulation of membrane repolarization during action potential,regulation of cardiac muscle cell action potential involved in regulation of contraction,regulation of ventricular cardiac muscle cell action potential,regulation of ruffle assembly,negative regulation of peptidyl-tyrosine autophosphorylation,negative regulation of potassium ion transmembrane transport,regulation of cell communication by electrical coupling involved in cardiac conduction,regulation of inward rectifier potassium channel activity,positive regulation of ER-associated ubiquitin-dependent protein catabolic process,protein localization to basolateral plasma membrane,positive regulation of gap junction assembly,beta-catenin destruction complex disassembly,receptor internalization involved in canonical Wnt signaling pathway,regulation of entry of bacterium into host cell,negative regulation of anoikis,positive regulation of extrinsic apoptotic signaling pathway,positive regulation of intrinsic apoptotic signaling pathwayreceptor binding,patched binding,structural molecule activity,protein binding,cholesterol binding,peptidase activator activity,enzyme binding,protein kinase binding,protein binding, bridging,protein complex scaffold,identical protein binding,ion channel binding,protein heterodimerization activity,Rac GTPase binding,nitric-oxide synthase binding,ATPase binding,inward rectifier potassium channel inhibitor activityGolgi membrane,acrosomal membrane,intracellular,endosome,endoplasmic reticulum,endoplasmic reticulum membrane,lipid particle,plasma membrane,integral component of plasma membrane,caveola,focal adhesion,cilium,cell cortex,membrane,endocytic vesicle membrane,cytoplasmic vesicle,early endosome membrane,protein complex,membrane raft,perinuclear region of cytoplasm,VCP-NPL4-UFD1 AAA ATPase complexJ>sp|Q03135|CAV1_HUMAN Caveolin-1 OS=Homo sapiens OX=9606 GN=CAV1 PE=1 SV=4P11234RALB RALB_HUMANRas-related protein Ral-Bcytokinesis,regulation of exocyst assembly,positive regulation of protein phosphorylation,apoptotic process,signal transduction,Ras protein signal transduction,cellular response to starvation,negative regulation of protein binding,positive regulation of protein binding,regulation of exocyst localization,cellular response to exogenous dsRNA,positive regulation of protein serine/threonine kinase activity,positive regulation of autophagosome assemblygGTPase activity,protein binding,GTP binding,GDP binding,ubiquitin protein ligase binding,ATPase bindingCplasma membrane,midbody,extracellular exosome,exocyst,autophagosomeY>sp|P11234|RALB_HUMAN Ras-related protein Ral-B OS=Homo sapiens OX=9606 GN=RALB PE=1 SV=1P16615ATP2A2 AT2A2_HUMAN3Sarcoplasmic/endoplasmic reticulum calcium ATPase 2<regulation of the force of heart contraction,ER-nucleus signaling pathway,organelle organization,cell adhesion,epidermis development,positive regulation of heart rate,regulation of cardiac muscle contraction by calcium ion signaling,transition between fast and slow fiber,cardiac muscle hypertrophy in response to stress,endoplasmic reticulum calcium ion homeostasis,positive regulation of endoplasmic reticulum calcium ion concentration,T-tubule organization,ion transmembrane transport,cellular response to oxidative stress,response to endoplasmic reticulum stress,negative regulation of heart contraction,relaxation of cardiac muscle,sarcoplasmic reticulum calcium ion transport,calcium ion transmembrane transport,regulation of cardiac muscle cell membrane potential,regulation of cardiac muscle cell action potential involved in regulation of contraction,Requires Ontology,regulation of calcium ion-dependent exocytosis of neurotransmitter,calcium ion transport from cytosol to endoplasmic reticulum,regulation of cardiac conduction,calcium ion import into sarcoplasmic reticulumcalcium-transporting ATPase activity,calcium ion binding,protein binding,ATP binding,enzyme binding,lutropin-choriogonadotropic hormone receptor binding,S100 protein binding,calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potentialYnucleoplasm,endoplasmic reticulum,endoplasmic reticulum membrane,integral component of plasma membrane,vesicle membrane,membrane,sarcoplasmic reticulum,platelet dense tubular network membrane,extrinsic component of cytoplasmic side of plasma membrane,sarcoplasmic reticulum membrane,protein complex,perinuclear region of cytoplasm,ribbon synapsev>sp|P16615|AT2A2_HUMAN Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 OS=Homo sapiens OX=9606 GN=ATP2A2 PE=1 SV=1Q16394EXT1 EXT1_HUMAN Exostosin-1skeletal system development,ossification,glycosaminoglycan biosynthetic process,protein glycosylation,signal transduction,gastrulation,axon guidance,endoderm development,mesoderm development,heparan sulfate proteoglycan biosynthetic process,heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process,olfactory bulb development,cellular polysaccharide biosynthetic process,embryonic skeletal joint developmentacetylglucosaminyltransferase activity,glucuronosyltransferase activity,transferase activity, transferring glycosyl groups,heparan sulfate N-acetylglucosaminyltransferase activity,protein homodimerization activity,metal ion binding,protein heterodimerization activity,glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity,N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activityGolgi membrane,endoplasmic reticulum,endoplasmic reticulum membrane,Golgi apparatus,integral component of membrane,integral component of endoplasmic reticulum membraneK>sp|Q16394|EXT1_HUMAN Exostosin-1 OS=Homo sapiens OX=9606 GN=EXT1 PE=1 SV=2Q9NRY6PLSCR3 PLS3_HUMANPhospholipid scramblase 3}apoptotic process,phospholipid scrambling,glucose homeostasis,cholesterol homeostasis,cellular response to lipopolysaccharide< ycalcium ion binding,protein binding,SH3 domain binding,phospholipid scramblase activity,calcium-dependent protein bindingSmitochondrion,plasma membrane,integral component of membrane,mitochondrial membrane[>sp|Q9NRY6|PLS3_HUMAN Phospholipid scramblase 3 OS=Homo sapiens OX=9606 GN=PLSCR3 PE=1 SV=2P11166SLC2A1 GTR1_HUMANASolute carrier family 2, facilitated glucose transporter member 1 lactose biosynthetic process,protein complex assembly,response to osmotic stress,glucose transport,L-ascorbic acid metabolic process,cellular response to glucose starvation,xenobiotic transport,regulation of insulin secretion,dehydroascorbic acid transport,glucose transmembrane transportglucose transmembrane transporter activity,protein binding,kinase binding,dehydroascorbic acid transporter activity,identical protein binding,xenobiotic transporter activity,protein self-association,D-glucose transmembrane transporter activityGolgi membrane,female pronucleus,cytosol,plasma membrane,integral component of plasma membrane,caveola,cell-cell junction,membrane,basolateral plasma membrane,apical plasma membrane,midbody,cortical actin cytoskeleton,melanosome,extracellular exosome,blood microparticle>sp|P11166|GTR1_HUMAN Solute carrier family 2, facilitated glucose transporter member 1 OS=Homo sapiens OX=9606 GN=SLC2A1 PE=1 SV=2Q6P9B6MEAK7 MEAK7_HUMANMTOR-associated protein MEAK7<negative regulation of oxidative stress-induced neuron deathlysosomal membrane_>sp|Q6P9B6|MEAK7_HUMAN MTOR-associated protein MEAK7 OS=Homo sapiens OX=9606 GN=MEAK7 PE=1 SV=2O95819MAP4K4 M4K4_HUMAN7Mitogen-activated protein kinase kinase kinase kinase 4protein phosphorylation,signal transduction by protein phosphorylation,intracellular signal transduction,negative regulation of apoptotic process,regulation of JNK cascade,microvillus assemblycreatine kinase activity,protein serine/threonine kinase activity,receptor signaling protein serine/threonine kinase activity,protein binding,ATP bindingy>sp|O95819|M4K4_HUMAN Mitogen-activated protein kinase kinase kinase kinase 4 OS=Homo sapiens OX=9606 GN=MAP4K4 PE=1 SV=2P62424RPL7A RL7A_HUMAN60S ribosomal protein L7anuclear-transcribed mRNA catabolic process, nonsense-mediated decay,maturation of LSU-rRNA,rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,viral transcriptionnucleus,nucleolus,cytoplasm,cytosol,focal adhesion,membrane,cytosolic large ribosomal subunit,polysomal ribosome,extracellular exosomeZ>sp|P62424|RL7A_HUMAN 60S ribosomal protein L7a OS=Homo sapiens OX=9606 GN=RPL7A PE=1 SV=2Q9H6X2ANTXR1 ANTR1_HUMANAnthrax toxin receptor 1blood vessel development,signal transduction,reproductive process,actin cytoskeleton reorganization,substrate adhesion-dependent cell spreading,negative regulation of extracellular matrix assembly,positive regulation of metallopeptidase activitystransmembrane signaling receptor activity,protein binding,collagen binding,metal ion binding,actin filament bindingplasma membrane,external side of plasma membrane,cell surface,endosome membrane,integral component of membrane,lamellipodium membrane,filopodium membrane,extracellular exosome[>sp|Q9H6X2|ANTR1_HUMAN Anthrax toxin receptor 1 OS=Homo sapiens OX=9606 GN=ANTXR1 PE=1 SV=2P02679FGG FIBG_HUMANFibrinogen gamma chaintoll-like receptor signaling pathway,platelet degranulation,cell-matrix adhesion,blood coagulation,protein secretion,extracellular matrix organization,plasminogen activation,positive regulation of heterotypic cell-cell adhesion,platelet maturation,fibrinolysis,cellular protein complex assembly,positive regulation of vasoconstriction,positive regulation of exocytosis,positive regulation of protein secretion,protein polymerization,response to calcium ion,positive regulation of ERK1 and ERK2 cascade,platelet aggregation,cellular response to interleukin-1,cellular response to interleukin-6,blood coagulation, fibrin clot formation,positive regulation of peptide hormone secretion,negative regulation of platelet aggregation,positive regulation of substrate adhesion-dependent cell spreading,negative regulation of extrinsic apoptotic signaling pathway via death domain receptors,negative regulation of endothelial cell apoptotic processreceptor binding,structural molecule activity,protein binding,protein binding, bridging,protein homodimerization activity,metal ion binding,cell adhesion molecule bindingextracellular region,fibrinogen complex,extracellular space,plasma membrane,cell cortex,external side of plasma membrane,cell surface,platelet alpha granule,platelet alpha granule lumen,extracellular exosome,blood microparticleU>sp|P02679|FIBG_HUMAN Fibrinogen gamma chain OS=Homo sapiens OX=9606 GN=FGG PE=1 SV=3Q04837SSBP1 SSBP_HUMAN2Single-stranded DNA-binding protein, mitochondrialoDNA replication,mitochondrion organization,positive regulation of helicase activity,mitochondrion morphogenesisIchromatin binding,single-stranded DNA binding,RNA binding,protein bindingWnucleus,mitochondrion,mitochondrial matrix,mitochondrial nucleoid,extracellular exosomes>sp|Q04837|SSBP_HUMAN Single-stranded DNA-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=SSBP1 PE=1 SV=1P39656DDOST OST48_HUMANMDolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunitprotein glycosylation,protein N-linked glycosylation,protein N-linked glycosylation via asparagine,response to cytokine,T cell activation,neutrophil degranulationwprotein binding,oligosaccharyl transferase activity,dolichyl-diphosphooligosaccharide-protein glycotransferase activityendoplasmic reticulum,endoplasmic reticulum membrane,plasma membrane,oligosaccharyltransferase complex,membrane,integral component of membrane,azurophil granule membrane,intracellular membrane-bounded organelle,protein complex>sp|P39656|OST48_HUMAN Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit OS=Homo sapiens OX=9606 GN=DDOST PE=1 SV=4P61313RPL15 RL15_HUMAN60S ribosomal protein L15nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,cytoplasmic translation,rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,viral transcription,response to ethanol`nucleus,cytosol,ribosome,membrane,cytosolic large ribosomal subunit,A band,extracellular exosomeZ>sp|P61313|RL15_HUMAN 60S ribosomal protein L15 OS=Homo sapiens OX=9606 GN=RPL15 PE=1 SV=2Q8WWI5SLC44A1 CTL1_HUMAN"Choline transporter-like protein 1lphosphatidylcholine biosynthetic process,choline transport,choline catabolic process,transmembrane transport*choline transmembrane transporter activitynucleoplasm,mitochondrion,mitochondrial outer membrane,plasma membrane,membrane,integral component of membrane,extracellular exosomee>sp|Q8WWI5|CTL1_HUMAN Choline transporter-like protein 1 OS=Homo sapiens OX=9606 GN=SLC44A1 PE=1 SV=1Q8IZ83ALDH16A1 A16A1_HUMAN*Aldehyde dehydrogenase family 16 member A1oxidation-reduction process%aldehyde dehydrogenase (NAD) activityo>sp|Q8IZ83|A16A1_HUMAN Aldehyde dehydrogenase family 16 member A1 OS=Homo sapiens OX=9606 GN=ALDH16A1 PE=1 SV=2O43399TPD52L2 TPD54_HUMANTumor protein D54U>sp|O43399|TPD54_HUMAN Tumor protein D54 OS=Homo sapiens OX=9606 GN=TPD52L2 PE=1 SV=2P42224STAT1 STAT1_HUMAN=Signal transducer and activator of transcription 1-alpha/betanegative regulation of transcription from RNA polymerase II promoter,negative regulation of endothelial cell proliferation,positive regulation of mesenchymal cell proliferation,negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis,transcription, DNA-templated,apoptotic process,JAK-STAT cascade,blood circulation,macrophage derived foam cell differentiation,negative regulation of angiogenesis,tumor necrosis factor-mediated signaling pathway,response to cytokine,response to interferon-beta,cellular response to interferon-beta,regulation of apoptotic process,negative regulation of I-kappaB kinase/NF-kappaB < signaling,response to peptide hormone,positive regulation of transcription, DNA-templated,positive regulation of transcription from RNA polymerase II promoter,negative regulation by virus of viral protein levels in host cell,positive regulation of smooth muscle cell proliferation,response to cAMP,defense response to virus,interferon-gamma-mediated signaling pathway,regulation of interferon-gamma-mediated signaling pathway,type I interferon signaling pathway,regulation of type I interferon-mediated signaling pathway,renal tubule development,metanephric mesenchymal cell proliferation involved in metanephros development,metanephric mesenchymal cell differentiation,negative regulation of metanephric nephron tubule epithelial cell differentiation,endothelial cell migrationRNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II core promoter sequence-specific DNA binding,transcription factor activity, RNA polymerase II core promoter sequence-specific,double-stranded DNA binding,transcription factor activity, sequence-specific DNA binding,signal transducer activity,tumor necrosis factor receptor binding,protein binding,enzyme binding,nuclear hormone receptor binding,identical protein binding,protein homodimerization activity,cadherin bindingonuclear chromatin,nucleus,nucleoplasm,nucleolus,cytoplasm,cytosol,axon,dendrite,perinuclear region of cytoplasm>sp|P42224|STAT1_HUMAN Signal transducer and activator of transcription 1-alpha/beta OS=Homo sapiens OX=9606 GN=STAT1 PE=1 SV=2P04632CAPNS1 CPNS1_HUMANCalpain small subunit 1proteolysis,positive regulation of cell proliferation,regulation of macroautophagy,extracellular matrix disassembly,cornificationqendopeptidase activity,calcium-dependent cysteine-type endopeptidase activity,calcium ion binding,protein binding6cytosol,plasma membrane,membrane,extracellular exosomeZ>sp|P04632|CPNS1_HUMAN Calpain small subunit 1 OS=Homo sapiens OX=9606 GN=CAPNS1 PE=1 SV=1Q12860CNTN1 CNTN1_HUMAN Contactin-1cell adhesion,Notch signaling pathway,positive regulation of gene expression,positive regulation of sodium ion transport,positive regulation of neuron projection development,cerebellum development,neuron projection development,positive regulation of peptidyl-tyrosine phosphorylation)glycoprotein binding,carbohydrate bindingiplasma membrane,membrane,anchored component of membrane,myelin sheath,membrane raft,extracellular exosomeM>sp|Q12860|CNTN1_HUMAN Contactin-1 OS=Homo sapiens OX=9606 GN=CNTN1 PE=1 SV=1Q96AQ6PBXIP1 PBIP1_HUMAN>Pre-B-cell leukemia transcription factor-interacting protein 1kmulticellular organism development,cell differentiation,negative regulation of transcription, DNA-templated2transcription corepressor activity,protein bindingnucleus,cytosol,microtubule>sp|Q96AQ6|PBIP1_HUMAN Pre-B-cell leukemia transcription factor-interacting protein 1 OS=Homo sapiens OX=9606 GN=PBXIP1 PE=1 SV=1 P36873;P62136 PPP1CC;PPP1CAPP1G_HUMAN;PP1A_HUMANSerine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase PP1-alpha catalytic subunitglycogen metabolic process,protein dephosphorylation,sister chromatid cohesion,neuron differentiation,circadian regulation of gene expression,regulation of circadian rhythm,entrainment of circadian clock by photoperiod,regulation of nucleocytoplasmic transport,cell division;glycogen metabolic process,regulation of glycogen biosynthetic process,regulation of glycogen catabolic process,protein dephosphorylation,cell cycle,dephosphorylation,lung development,negative regulation of protein binding,circadian regulation of gene expression,regulation of translational initiation by eIF2 alpha dephosphorylation,regulation of circadian rhythm,entrainment of circadian clock by photoperiod,branching morphogenesis of an epithelial tube,cell division,regulation of canonical Wnt signaling pathway,cell-cell adhesion,beta-catenin destruction complex disassembly,positive regulation of extrinsic apoptotic signaling pathway in absence of ligandVRNA binding,phosphoprotein phosphatase activity,protein serine/threonine phosphatase activity,protein binding,lamin binding,protein C-terminus binding,protein phosphatase 1 binding,phosphatase activity,protein kinase binding,protein domain specific binding,protein complex binding,metal ion binding,protein N-terminus binding;phosphoprotein phosphatase activity,protein serine/threonine phosphatase activity,protein binding,protein phosphatase 1 binding,phosphatase activity,protein complex binding,ribonucleoprotein complex binding,metal ion binding,cadherin binding involved in cell-cell adhesioncondensed chromosome kinetochore,nucleus,nucleolus,cytoplasm,mitochondrion,mitochondrial outer membrane,cytosol,focal adhesion,nuclear speck,midbody,cleavage furrow,dendritic spine,protein complex,PTW/PP1 phosphatase complex,nuclear chromosome, telomeric region;protein phosphatase type 1 complex,nucleus,nucleoplasm,nucleolus,cytoplasm,cytosol,plasma membrane,cell-cell adherens junction,glycogen granule,dendritic spine,perikaryon,extracellular exosome,PTW/PP1 phosphatase complex,nuclear chromosome, telomeric region>sp|P36873|PP1G_HUMAN Serine/threonine-protein phosphatase PP1-gamma catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CC PE=1 SV=1;>sp|P62136|PP1A_HUMAN Serine/threonine-protein phosphatase PP1-alpha catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CA PE=1 SV=1Q13637RAB32 RAB32_HUMANRas-related protein Rab-32mitochondrion organization,small GTPase mediated signal transduction,vesicle-mediated transport,antigen processing and presentation,endosome to melanosome transport,membrane organization,protein localization to membrane,phagosome maturation,melanosome assemblyGTPase activity,protein binding,GTP binding,GTP-dependent protein binding,AP-1 adaptor complex binding,AP-3 adaptor complex binding,BLOC-2 complex binding,AP-2 adaptor complex bindingmitochondrion,mitochondrial outer membrane,early endosome,endoplasmic reticulum,trans-Golgi network,cytosol,membrane,phagocytic vesicle membrane,melanosome membrane,melanosome,ER-mitochondrion membrane contact site,phagocytic vesicle,early endosome lumen\>sp|Q13637|RAB32_HUMAN Ras-related protein Rab-32 OS=Homo sapiens OX=9606 GN=RAB32 PE=1 SV=3P16070CD44 CD44_HUMAN CD44 antigencell-matrix adhesion,single organismal cell-cell adhesion,extracellular matrix disassembly,extracellular matrix organization,hyaluronan catabolic process,positive regulation of peptidyl-serine phosphorylation,positive regulation of heterotypic cell-cell adhesion,negative regulation of apoptotic process,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process,neutrophil degranulation,negative regulation of DNA damage response, signal transduction by p53 class mediator,cellular response to fibroblast growth factor stimulus,positive regulation of peptidyl-tyrosine phosphorylation,leukocyte migration,cartilage development,interferon-gamma-mediated signaling pathway,positive regulation of ERK1 and ERK2 cascade,monocyte aggregation,positive regulation of monocyte aggregation,negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorSprotein binding,collagen binding,hyaluronic acid binding,cytokine receptor activityGolgi apparatus,cytosol,plasma membrane,integral component of plasma membrane,focal adhesion,cell surface,secretory granule membrane,macrophage migration inhibitory factor receptor complex,extracellular exosomeL>sp|P16070|CD44_HUMAN CD44 antigen OS=Homo sapiens OX=9606 GN=CD44 PE=1 SV=3P62805H4C1H4_HUMAN Histone H4Ochromatin silencing at rDNA,double-strand break repair via nonhomologous end joining,nucleosome assembly,DNA replication-dependent nucleosome assembly,DNA replication-independent nucleosome assembly,DNA-templated transcription, initiation,telomere capping,gene silencing by RNA,telomere organization,CENP-A containing nucleosome assembly,cellular protein metabolic process,negative regulation of megakaryocyte differentiation,negative regulation of gene expression, epigenetic< ,positive regulation of gene expression, epigenetic,protein heterotetramerization,beta-catenin-TCF complex assembly{DNA binding,RNA binding,protein binding,protein domain specific binding,histone binding,protein heterodimerization activitynuclear chromosome,nuclear chromosome, telomeric region,nucleosome,nuclear nucleosome,extracellular region,nucleus,nucleoplasm,membrane,extracellular matrix,protein complex,extracellular exosomeH>sp|P62805|H4_HUMAN Histone H4 OS=Homo sapiens OX=9606 GN=H4C1 PE=1 SV=2Q13591SEMA5A SEM5A_HUMAN Semaphorin-5Apositive regulation of endothelial cell proliferation,blood vessel endothelial cell proliferation involved in sprouting angiogenesis,cell adhesion,negative regulation of cell adhesion,cell-cell signaling,nervous system development,axonal fasciculation,diencephalon development,positive regulation of actin filament depolymerization,positive regulation of catenin import into nucleus,positive regulation of angiogenesis,positive regulation of axon extension involved in axon guidance,negative regulation of axon extension involved in axon guidance,positive chemotaxis,positive regulation of protein kinase B signaling,cell chemotaxis,signal clustering,negative regulation of endothelial cell apoptotic process,positive regulation of endothelial cell chemotaxiszsemaphorin receptor binding,chondroitin sulfate proteoglycan binding,heparan sulfate proteoglycan binding,syndecan bindingMplasma membrane,membrane,integral component of membrane,extracellular exosomeP>sp|Q13591|SEM5A_HUMAN Semaphorin-5A OS=Homo sapiens OX=9606 GN=SEMA5A PE=1 SV=3P16035TIMP2 TIMP2_HUMANMetalloproteinase inhibitor 2wcentral nervous system development,aging,negative regulation of cell proliferation,response to hormone,negative regulation of endopeptidase activity,extracellular matrix disassembly,regulation of Rap protein signal transduction,response to cytokine,response to drug,neutrophil degranulation,positive regulation of MAPK cascade,positive regulation of neuron differentiation,positive regulation of adenylate cyclase activity,negative regulation of mitotic cell cycle,negative regulation of Ras protein signal transduction,negative regulation of membrane protein ectodomain proteolysis,negative regulation of metallopeptidase activitykprotease binding,integrin binding,protein binding,metalloendopeptidase inhibitor activity,metal ion bindingextracellular region,proteinaceous extracellular matrix,extracellular space,cell surface,growth cone,extracellular matrix,specific granule lumen,neuronal cell body,extracellular exosome,tertiary granule lumen,ficolin-1-rich granule lumen_>sp|P16035|TIMP2_HUMAN Metalloproteinase inhibitor 2 OS=Homo sapiens OX=9606 GN=TIMP2 PE=1 SV=2P47897QARS1 SYQ_HUMANGlutamine--tRNA ligase\tRNA aminoacylation for protein translation,glutaminyl-tRNA aminoacylation,brain development:glutamine-tRNA ligase activity,protein binding,ATP binding&cytoplasm,mitochondrial matrix,cytosolV>sp|P47897|SYQ_HUMAN Glutamine--tRNA ligase OS=Homo sapiens OX=9606 GN=QARS1 PE=1 SV=1Q15436SEC23A SC23A_HUMAN Protein transport protein Sec23Aantigen processing and presentation of peptide antigen via MHC class I,intracellular protein transport,ER to Golgi vesicle-mediated transport,vesicle-mediated transport,antigen processing and presentation of exogenous peptide antigen via MHC class II,COPII vesicle coating protein binding,zinc ion bindingGolgi membrane,endoplasmic reticulum,endoplasmic reticulum membrane,cytosol,ER to Golgi transport vesicle membrane,COPII vesicle coat,smooth endoplasmic reticulum membrane,perinuclear region of cytoplasmc>sp|Q15436|SC23A_HUMAN Protein transport protein Sec23A OS=Homo sapiens OX=9606 GN=SEC23A PE=1 SV=2P15311EZR EZRI_HUMANEzrinenegative regulation of transcription from RNA polymerase II promoter,intestinal D-glucose absorption,sphingosine-1-phosphate signaling pathway,cytoskeletal anchoring at plasma membrane,leukocyte cell-cell adhesion,axon guidance,regulation of cell shape,positive regulation of gene expression,protein kinase A signaling,membrane to membrane docking,microvillus assembly,astral microtubule organization,actin cytoskeleton reorganization,receptor internalization,regulation of microvillus length,cellular protein complex localization,positive regulation of multicellular organism growth,cortical microtubule organization,filopodium assembly,phosphatidylinositol-mediated signaling,positive regulation of protein secretion,negative regulation of T cell receptor signaling pathway,actin filament bundle assembly,establishment of centrosome localization,establishment of endothelial barrier,negative regulation of ERK1 and ERK2 cascade,cellular response to cAMP,protein localization to cell cortex,establishment of protein localization to plasma membrane,positive regulation of establishment of protein localization to plasma membrane,negative regulation of interleukin-2 secretion,regulation of organelle assembly,terminal web assembly,positive regulation of protein localization to early endosome,positive regulation of cellular protein catabolic process,negative regulation of p38MAPK cascade,positive regulation of early endosome to late endosome transport,regulation of cell size,gland morphogenesis,regulation of actin cytoskeleton organization,establishment of epithelial cell apical/basal polarity,regulation of NIK/NF-kappaB signalingRNA binding,actin binding,protein binding,microtubule binding,protein domain specific binding,protein kinase A catalytic subunit binding,protein kinase A regulatory subunit binding,S100 protein binding,cadherin binding,cell adhesion molecule binding,actin filament binding,ATPase bindingfibrillar center,ruffle,immunological synapse,uropod,extracellular space,cytoplasm,endosome,cytosol,actin filament,plasma membrane,microvillus,brush border,focal adhesion,actin cytoskeleton,membrane,basolateral plasma membrane,apical plasma membrane,extrinsic component of membrane,filopodium,T-tubule,cortical cytoskeleton,microvillus membrane,vesicle,ruffle membrane,ciliary basal body,cell projection,myelin sheath,cell body,microspike,plasma membrane raft,apical part of cell,perinuclear region of cytoplasm,cell tip,extracellular exosome,cell periphery,astrocyte projection,Schwann cell microvillus,cytoplasmic side of apical plasma membrane,TCR signalosomeD>sp|P15311|EZRI_HUMAN Ezrin OS=Homo sapiens OX=9606 GN=EZR PE=1 SV=4Q9UQ80PA2G4 PA2G4_HUMAN$Proliferation-associated protein 2G4 transcription, DNA-templated,rRNA processing,regulation of translation,cell cycle arrest,cell proliferation,negative regulation of apoptotic process,neutrophil degranulation,positive regulation of cell differentiation,negative regulation of transcription, DNA-templatedDNA binding,transcription factor activity, sequence-specific DNA binding,RNA binding,protein binding,ubiquitin protein ligase bindingextracellular region,nucleus,nucleolus,cytoplasm,membrane,intracellular ribonucleoprotein complex,azurophil granule lumen,extracellular exosomef>sp|Q9UQ80|PA2G4_HUMAN Proliferation-associated protein 2G4 OS=Homo sapiens OX=9606 GN=PA2G4 PE=1 SV=3 B5ME19;Q99613 EIF3CL;EIF3CEIFCL_HUMAN;EIF3C_HUMANvEukaryotic translation initiation factor 3 subunit C-like protein;Eukaryotic translation initiation factor 3 subunit Cxtranslational initiation;translational initiation,positive regulation of translation,positive regulation of mRNA bindingtranslation initiation factor binding,translation initiation factor activity;RNA binding,protein binding,translation initiation factor binding,translation initiation factor activitymeukaryotic translation initiation factor 3 complex;cytosol,eukaryotic translation initiation factor 3 complex>sp|B5ME19|EIFCL_HUMAN Eukaryotic translation initiation factor 3 subunit C-like protein OS=Homo sapiens OX=9606 GN=EIF3CL PE=1 SV=1;>sp|Q99613|EIF3C_HUMAN Eukaryotic translation initiation factor 3 subunit C OS=Homo sapiens OX=9606 GN=EIF3C PE=1 SV=1Q8NG11TSPAN14 TSN14_HUMANTetraspanin-14neutrophil degranulation,positive regulation of Notch signaling pathway,protein maturation,establishment of< protein localization to plasma membraneenzyme bindingplasma membrane,integral component of plasma membrane,cell surface,specific granule membrane,tertiary granule membrane,tetraspanin-enriched microdomainR>sp|Q8NG11|TSN14_HUMAN Tetraspanin-14 OS=Homo sapiens OX=9606 GN=TSPAN14 PE=1 SV=1Q7L1Q6BZW1 BZW1_HUMAN7Basic leucine zipper and W2 domain-containing protein 1Gtranscription, DNA-templated,regulation of transcription, DNA-templatedcytoplasm,membranew>sp|Q7L1Q6|BZW1_HUMAN Basic leucine zipper and W2 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=BZW1 PE=1 SV=1Q92499DDX1 DDX1_HUMANATP-dependent RNA helicase DDX1spliceosomal complex assembly,double-strand break repair,transcription, DNA-templated,regulation of transcription, DNA-templated,tRNA splicing, via endonucleolytic cleavage and ligation,regulation of translational initiation,multicellular organism development,response to virus,RNA secondary structure unwinding,DNA duplex unwinding,response to exogenous dsRNA,nucleic acid phosphodiester bond hydrolysis,protein localization to cytoplasmic stress granule,DNA binding,chromatin binding,transcription cofactor activity,RNA binding,RNA helicase activity,double-stranded RNA binding,ATP-dependent RNA helicase activity,nuclease activity,exonuclease activity,protein binding,ATP binding,ATP-dependent helicase activity,poly(A) binding,DNA/RNA helicase activitynucleus,nucleoplasm,cytoplasm,cytosol,cytoplasmic stress granule,membrane,intracellular ribonucleoprotein complex,cleavage body,tRNA-splicing ligase complex_>sp|Q92499|DDX1_HUMAN ATP-dependent RNA helicase DDX1 OS=Homo sapiens OX=9606 GN=DDX1 PE=1 SV=2P60891PRPS1 PRPS1_HUMAN$Ribose-phosphate pyrophosphokinase 1C5-phosphoribose 1-diphosphate biosynthetic process,purine nucleobase metabolic process,purine nucleotide biosynthetic process,AMP biosynthetic process,pyrimidine nucleotide biosynthetic process,nervous system development,phosphorylation,animal organ regeneration,urate biosynthetic process,hypoxanthine biosynthetic processmagnesium ion binding,ribose phosphate diphosphokinase activity,protein binding,ATP binding,AMP binding,kinase activity,GDP binding,carbohydrate binding,identical protein binding,protein homodimerization activity,ADP binding@ribose phosphate diphosphokinase complex,cytosol,protein complexf>sp|P60891|PRPS1_HUMAN Ribose-phosphate pyrophosphokinase 1 OS=Homo sapiens OX=9606 GN=PRPS1 PE=1 SV=2P13861PRKAR2A KAP2_HUMAN>cAMP-dependent protein kinase type II-alpha regulatory subunitrenal water homeostasis,blood coagulation,activation of protein kinase A activity,intracellular signal transduction,cellular response to glucagon stimulus,negative regulation of cAMP-dependent protein kinase activitycAMP-dependent protein kinase inhibitor activity,protein binding,cAMP-dependent protein kinase regulator activity,cAMP binding,ubiquitin protein ligase binding,protein kinase A catalytic subunit bindingcytoplasm,centrosome,cytosol,plasma membrane,focal adhesion,cAMP-dependent protein kinase complex,membrane,nucleotide-activated protein kinase complex,plasma membrane raft,extracellular exosome,ciliary base>sp|P13861|KAP2_HUMAN cAMP-dependent protein kinase type II-alpha regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR2A PE=1 SV=2P16403H1-2 H12_HUMAN Histone H1.2negative regulation of transcription from RNA polymerase II promoter,nucleosome assembly,nucleosome positioning,histone H3-K4 trimethylation,histone H3-K27 trimethylation1RNA binding,protein binding,chromatin DNA bindingInucleosome,nucleus,nuclear euchromatin,transcriptionally active chromatinK>sp|P16403|H12_HUMAN Histone H1.2 OS=Homo sapiens OX=9606 GN=H1-2 PE=1 SV=2O00487PSMD14 PSDE_HUMAN/26S proteasome non-ATPase regulatory subunit 14MAPK cascade,protein polyubiquitination,double-strand break repair via homologous recombination,stimulatory C-type lectin receptor signaling pathway,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent,double-strand break repair via nonhomologous end joining,ubiquitin-dependent protein catabolic process,regulation of cellular amino acid metabolic process,positive regulation of endopeptidase activity,negative regulation of G2/M transition of mitotic cell cycle,protein deubiquitination,anaphase-promoting complex-dependent catabolic process,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process,tumor necrosis factor-mediated signaling pathway,NIK/NF-kappaB signaling,Fc-epsilon receptor signaling pathway,proteasome-mediated ubiquitin-dependent protein catabolic process,neutrophil degranulation,regulation of mRNA stability,response to ethanol,T cell receptor signaling pathway,negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition,transmembrane transport,Wnt signaling pathway, planar cell polarity pathway,regulation of proteasomal protein catabolic process,regulation of transcription from RNA polymerase II promoter in response to hypoxia,protein K63-linked deubiquitination,negative regulation of canonical Wnt signaling pathway,positive regulation of canonical Wnt signaling pathwayprotein binding,metallopeptidase activity,metal ion binding,endopeptidase activator activity,Lys63-specific deubiquitinase activity,proteasome bindingproteasome complex,extracellular region,nucleus,nucleoplasm,cytosol,proteasome regulatory particle, lid subcomplex,proteasome accessory complex,cytosolic proteasome complex,secretory granule lumen,extracellular exosome,ficolin-1-rich granule lumenq>sp|O00487|PSDE_HUMAN 26S proteasome non-ATPase regulatory subunit 14 OS=Homo sapiens OX=9606 GN=PSMD14 PE=1 SV=1P00747PLG PLMN_HUMAN Plasminogenwplatelet degranulation,proteolysis,blood coagulation,negative regulation of cell proliferation,negative regulation of cell-substrate adhesion,extracellular matrix disassembly,fibrinolysis,cellular protein metabolic process,tissue remodeling,negative regulation of fibrinolysis,positive regulation of fibrinolysis,negative regulation of cell-cell adhesion mediated by cadherinserine-type endopeptidase activity,receptor binding,protein binding,serine-type peptidase activity,protein domain specific binding,apolipoprotein bindingextracellular region,extracellular space,plasma membrane,cell surface,platelet alpha granule lumen,extrinsic component of external side of plasma membrane,extracellular exosome,blood microparticleJ>sp|P00747|PLMN_HUMAN Plasminogen OS=Homo sapiens OX=9606 GN=PLG PE=1 SV=2Q92598HSPH1 HS105_HUMANHeat shock protein 105 kDaLreceptor-mediated endocytosis,response to unfolded protein,positive regulation of MHC class I biosynthetic process,positive regulation of transcription from RNA polymerase II promoter,chaperone mediated protein folding requiring cofactor,positive regulation of NK T cell activation,positive regulation of protein tyrosine kinase activity,regulation of cellular response to heat,negative regulation of establishment of protein localization to mitochondrion,negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide,negative regulation of p38MAPK cascade\adenyl-nucleotide exchange factor activity,protein binding,ATP binding,alpha-tubulin bindinglextracellular region,nucleoplasm,cytoplasm,cytosol,microtubule,extracellular exosome,endocytic vesicle lumen\>sp|Q92598|HS105_HUMAN Heat shock protein 105 kDa OS=Homo sapiens OX=9606 GN=HSPH1 PE=1 SV=1P30050RPL12 RL12_HUMAN60S ribosomal protein L12ribosomal large subunit assembly,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,viral transcriptionvnucleolus,cytosol,focal adhesion,membrane,cytosolic large ribosomal subunit,extracellular matrix,extracellular exosomeZ>sp|P30050|RL12_HUMAN 60S ribosomal protein L12 OS=Homo sapiens OX=9606 GN=RPL12 PE=1 SV=1P12259F5 FA5_HUMANCoagulation factor< Vplatelet degranulation,proteolysis,ER to Golgi vesicle-mediated transport,blood coagulation,blood circulation,platelet activation,response to vitamin K,COPII vesicle coatingEserine-type endopeptidase activity,copper ion binding,protein bindingGolgi membrane,extracellular region,extracellular space,endoplasmic reticulum lumen,plasma membrane,membrane,ER to Golgi transport vesicle,platelet alpha granule lumen,endoplasmic reticulum-Golgi intermediate compartment membrane,extracellular vesicleQ>sp|P12259|FA5_HUMAN Coagulation factor V OS=Homo sapiens OX=9606 GN=F5 PE=1 SV=4P27635RPL10 RL10_HUMAN60S ribosomal protein L10Z>sp|P27635|RL10_HUMAN 60S ribosomal protein L10 OS=Homo sapiens OX=9606 GN=RPL10 PE=1 SV=4O00303EIF3F EIF3F_HUMAN4Eukaryotic translation initiation factor 3 subunit F_translational initiation,protein deubiquitination,IRES-dependent viral translational initiationtranslation initiation factor activity,thiol-dependent ubiquitin-specific protease activity,protein binding,translation initiation factor bindingv>sp|O00303|EIF3F_HUMAN Eukaryotic translation initiation factor 3 subunit F OS=Homo sapiens OX=9606 GN=EIF3F PE=1 SV=1P62269RPS18 RS18_HUMAN40S ribosomal protein S18bRNA binding,structural constituent of ribosome,protein binding,rRNA binding,protein kinase bindingnucleus,nucleoplasm,cytosol,ribosome,focal adhesion,small ribosomal subunit,membrane,cytosolic small ribosomal subunit,extracellular matrix,extracellular exosomeZ>sp|P62269|RS18_HUMAN 40S ribosomal protein S18 OS=Homo sapiens OX=9606 GN=RPS18 PE=1 SV=3P69905HBA1 HBA_HUMANHemoglobin subunit alphareceptor-mediated endocytosis,positive regulation of cell death,oxygen transport,bicarbonate transport,response to hydrogen peroxide,hydrogen peroxide catabolic process,protein heterooligomerization,cellular oxidant detoxificationoxygen transporter activity,iron ion binding,protein binding,oxygen binding,heme binding,peroxidase activity,haptoglobin bindingextracellular region,cytosol,hemoglobin complex,membrane,cytosolic small ribosomal subunit,haptoglobin-hemoglobin complex,extracellular exosome,endocytic vesicle lumen,blood microparticleW>sp|P69905|HBA_HUMAN Hemoglobin subunit alpha OS=Homo sapiens OX=9606 GN=HBA1 PE=1 SV=2P67775PPP2CA PP2AA_HUMANGSerine/threonine-protein phosphatase 2A catalytic subunit alpha isoformnuclear-transcribed mRNA catabolic process, nonsense-mediated decay,inactivation of MAPK activity,regulation of DNA replication,regulation of transcription, DNA-templated,protein dephosphorylation,ceramide metabolic process,apoptotic process,mitotic nuclear envelope reassembly,mesoderm development,RNA splicing,response to organic substance,negative regulation of epithelial to mesenchymal transition,second-messenger-mediated signaling,regulation of Wnt signaling pathway,regulation of cell adhesion,negative regulation of cell growth,regulation of growth,negative regulation of tyrosine phosphorylation of Stat3 protein,regulation of cell differentiation,meiotic cell cycle,positive regulation of protein serine/threonine kinase activityvphosphoprotein phosphatase activity,protein binding,protein C-terminus binding,metal ion binding,GABA receptor bindingprotein phosphatase type 2A complex,chromosome, centromeric region,spindle pole,nucleus,mitochondrion,cytosol,plasma membrane,microtubule cytoskeleton,membrane,extracellular exosome>sp|P67775|PP2AA_HUMAN Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform OS=Homo sapiens OX=9606 GN=PPP2CA PE=1 SV=1 O14950;P19105 MYL12B;MYL12AML12B_HUMAN;ML12A_HUMANCMyosin regulatory light chain 12B;Myosin regulatory light chain 12Aumuscle contraction,regulation of cell shape;muscle contraction,ephrin receptor signaling pathway,platelet aggregationbcalcium ion binding,protein binding,myosin heavy chain binding;calcium ion binding,protein bindingstress fiber,cytosol,brush border,myosin II complex,Z disc,apical part of cell,extracellular exosome;cytosol,myosin complex,extracellular exosome>sp|O14950|ML12B_HUMAN Myosin regulatory light chain 12B OS=Homo sapiens OX=9606 GN=MYL12B PE=1 SV=2;>sp|P19105|ML12A_HUMAN Myosin regulatory light chain 12A OS=Homo sapiens OX=9606 GN=MYL12A PE=1 SV=2P19823ITIH2 ITIH2_HUMAN,Inter-alpha-trypsin inhibitor heavy chain H2Jnegative regulation of endopeptidase activity,hyaluronan metabolic process>extracellular region,extracellular exosome,blood microparticlen>sp|P19823|ITIH2_HUMAN Inter-alpha-trypsin inhibitor heavy chain H2 OS=Homo sapiens OX=9606 GN=ITIH2 PE=1 SV=2P67809YBX1 YBOX1_HUMANY-box-binding protein 1negative regulation of transcription from RNA polymerase II promoter,mRNA splicing, via spliceosome,in utero embryonic development,regulation of transcription, DNA-templated,transcription from RNA polymerase II promoter,positive regulation of transcription from RNA polymerase II promoter,negative regulation of striated muscle cell differentiation,positive regulation of cell division,CRD-mediated mRNA stabilization,protein localization to cytoplasmic stress granuleyRNA polymerase II core promoter proximal region sequence-specific DNA binding,transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding,DNA binding,chromatin binding,double-stranded DNA binding,single-stranded DNA binding,transcription factor activity, sequence-specific DNA binding,RNA binding,protein binding,GTPase binding$nucleus,nucleoplasm,U12-type spliceosomal complex,cytoplasm,cytosol,cytoplasmic stress granule,intracellular ribonucleoprotein complex,nuclear membrane,intracellular membrane-bounded organelle,extracellular exosome,CRD-mediated mRNA stability complex,histone pre-mRNA 3'end processing complexX>sp|P67809|YBOX1_HUMAN Y-box-binding protein 1 OS=Homo sapiens OX=9606 GN=YBX1 PE=1 SV=3P07741APRT APT_HUMAN!Adenine phosphoribosyltransferaseadenine salvage,lactation,grooming behavior,cellular response to insulin stimulus,purine-containing compound salvage,neutrophil degranulation,AMP salvageFadenine binding,adenine phosphoribosyltransferase activity,AMP binding`extracellular region,nucleoplasm,cytoplasm,cytosol,secretory granule lumen,extracellular exosome`>sp|P07741|APT_HUMAN Adenine phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=APRT PE=1 SV=2Q86UX7FERMT3 URP2_HUMANFermitin family homolog 3platelet degranulation,leukocyte cell-cell adhesion,integrin-mediated signaling pathway,positive regulation of cell migration,integrin activation,regulation of cell-cell adhesion mediated by integrin,substrate adhesion-dependent cell spreading,platelet aggregationintegrin bindingwpodosome,extracellular region,membrane,cell junction,platelet alpha granule lumen,cell projection,extracellular exosome[>sp|Q86UX7|URP2_HUMAN Fermitin family homolog 3 OS=Homo sapiens OX=9606 GN=FERMT3 PE=1 SV=1Q13885TUBB2A TBB2A_HUMANTubulin beta-2A chain3cytoskeleton organization,microtubule-based processRGTPase activity,structural constituent of cytoskeleton,protein binding,GTP bindingbnucleus,cytoplasm,microtubule,microtubule cytoskeleton,extracellular exosome,extracellular vesicleX>sp|Q13885|TBB2A_HUMAN Tubulin beta-2A chain OS=Homo sapiens OX=9606 GN=TUBB2A PE=1 SV=1Q8N474SFRP1 SFRP1_HUMAN#Secreted frizzled-related protein 1osteoblast differentiation,ureteric bud development,positive regulation of cell-matrix adhesion,hematopoietic progenitor cell differentiation,proteolysis,positive regulation of cell proliferation,negative regulation of cell proliferation,male gonad development,female gonad development,cellular response to starvation,dorsal/ventral axis specification,regulation of cell cycle process,negative regulation of gene expression,negative regulation of epithelial to mesenchymal transition,regulation of neuron projection development,neural crest cell fate commitment,response to organic cyclic compound,menstrual cycle phase,positive regulation of Wnt signaling pathway,negative regulation of Wnt signaling pathway,negative regulation of ossification,positive regulation of cell growth,ne< gative regulation of cell growth,negative regulation of cell migration,negative regulation of BMP signaling pathway,negative regulation of osteoblast proliferation,somatic stem cell population maintenance,response to drug,positive regulation of apoptotic process,negative regulation of apoptotic process,negative regulation of JUN kinase activity,positive regulation of GTPase activity,cellular response to fibroblast growth factor stimulus,stromal-epithelial cell signaling involved in prostate gland development,negative regulation of B cell differentiation,positive regulation of fat cell differentiation,negative regulation of osteoblast differentiation,negative regulation of osteoclast differentiation,regulation of angiogenesis,positive regulation of smoothened signaling pathway,negative regulation of transcription, DNA-templated,positive regulation of transcription, DNA-templated,negative regulation of insulin secretion,negative regulation of bone remodeling,negative regulation of fibroblast proliferation,digestive tract morphogenesis,positive regulation of epithelial cell proliferation,negative regulation of epithelial cell proliferation,negative regulation of peptidyl-tyrosine phosphorylation,positive regulation of stress fiber assembly,positive regulation of focal adhesion assembly,canonical Wnt signaling pathway,hematopoietic stem cell differentiation,bone trabecula formation,prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis,regulation of branching involved in prostate gland morphogenesis,negative regulation of androgen receptor signaling pathway,cellular response to vitamin D,cellular response to interleukin-1,cellular response to tumor necrosis factor,cellular response to growth factor stimulus,cellular response to prostaglandin E stimulus,cellular response to estrogen stimulus,cellular response to estradiol stimulus,cellular response to hypoxia,cellular response to X-ray,cellular response to heparin,dopaminergic neuron differentiation,cellular response to transforming growth factor beta stimulus,cellular response to BMP stimulus,negative regulation of canonical Wnt signaling pathway,planar cell polarity pathway involved in neural tube closure,Wnt signaling pathway involved in somitogenesis,convergent extension involved in somitogenesis,positive regulation of canonical Wnt signaling pathway,positive regulation of extrinsic apoptotic signaling pathway via death domain receptors,regulation of midbrain dopaminergic neuron differentiation,negative regulation of planar cell polarity pathway involved in axis elongation,positive regulation of non-canonical Wnt signaling pathway,negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification,negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation,negative regulation of fibroblast apoptotic process,positive regulation of fibroblast apoptotic processcysteine-type endopeptidase activity,frizzled binding,protein binding,drug binding,heparin binding,Wnt-protein binding,identical protein bindingextracellular region,proteinaceous extracellular matrix,extracellular space,intracellular,cytosol,plasma membrane,cell surface,extracellular matrix,extracellular exosomee>sp|Q8N474|SFRP1_HUMAN Secreted frizzled-related protein 1 OS=Homo sapiens OX=9606 GN=SFRP1 PE=1 SV=1Q99436PSMB7 PSB7_HUMANProteasome subunit beta type-7MAPK cascade,protein polyubiquitination,stimulatory C-type lectin receptor signaling pathway,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent,regulation of cellular amino acid metabolic process,negative regulation of G2/M transition of mitotic cell cycle,viral process,protein deubiquitination,anaphase-promoting complex-dependent catabolic process,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process,tumor necrosis factor-mediated signaling pathway,NIK/NF-kappaB signaling,Fc-epsilon receptor signaling pathway,proteasome-mediated ubiquitin-dependent protein catabolic process,neutrophil degranulation,regulation of mRNA stability,T cell receptor signaling pathway,negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition,transmembrane transport,Wnt signaling pathway, planar cell polarity pathway,regulation of transcription from RNA polymerase II promoter in response to hypoxia,negative regulation of canonical Wnt signaling pathway,positive regulation of canonical Wnt signaling pathway,positive regulation of protein targeting to mitochondrionproteasome complex,extracellular region,nucleus,nucleoplasm,cytosol,proteasome core complex,secretory granule lumen,extracellular exosome,ficolin-1-rich granule lumen_>sp|Q99436|PSB7_HUMAN Proteasome subunit beta type-7 OS=Homo sapiens OX=9606 GN=PSMB7 PE=1 SV=1Q9HCU0CD248 CD248_HUMAN Endosialinbiological_process,positive regulation of cell proliferation,cell migration,lymph node development,anatomical structure regression,positive regulation of endothelial cell apoptotic processXmolecular_function,calcium ion binding,carbohydrate binding,extracellular matrix bindingaproteinaceous extracellular matrix,cytoplasm,integral component of membrane,extracellular exosomeL>sp|Q9HCU0|CD248_HUMAN Endosialin OS=Homo sapiens OX=9606 GN=CD248 PE=1 SV=1P62879GNB2 GBB2_HUMAN@Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2protein folding,G-protein coupled receptor signaling pathway,regulation of molecular function,cellular response to glucagon stimulusGTPase activity,signal transducer activity,calcium channel regulator activity,protein binding,protein complex binding,GTPase bindingextracellular space,lysosomal membrane,cytosol,plasma membrane,focal adhesion,membrane,vesicle,myelin sheath,protein complex,cell body,perinuclear region of cytoplasm,extracellular exosome>sp|P62879|GBB2_HUMAN Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 OS=Homo sapiens OX=9606 GN=GNB2 PE=1 SV=3P23528CFL1 COF1_HUMAN Cofilin-1*protein import into nucleus,cytoskeleton organization,negative regulation of cell adhesion,Rho protein signal transduction,response to virus,positive regulation of lamellipodium assembly,negative regulation of lamellipodium assembly,response to organic cyclic compound,response to activity,hippocampus development,regulation of cell morphogenesis,cell projection organization,actin cytoskeleton organization,actin filament depolymerization,positive regulation of synaptic plasticity,negative regulation of actin filament bundle assembly,negative regulation of apoptotic process,positive regulation by host of viral process,negative regulation of cell size,positive regulation of proteolysis,negative regulation of unidimensional cell growth,positive regulation of focal adhesion assembly,positive regulation of dendritic spine development,regulation of dendritic spine morphogenesis,cellular response to hydrogen peroxide,cellular response to interleukin-1,cellular response to interleukin-6,cellular response to tumor necrosis factor,cellular response to ether,cellular response to epidermal growth factor stimulus,postsynaptic density assembly,negative regulation of dendritic spine maintenance,positive regulation of protein localization to cell periphery,positive regulation of NMDA glutamate receptor activity,cellular response to insulin-like growth factor stimulus,negative regulation of cell motility,positive regulation of cell motility,positive regulation of establishment of cell polarity regulating cell shape,positive regulation of barbed-end actin filament cappinglprotein binding,protein phosphatase binding,actin filament binding,phosphatidylinositol bisphosphate binding extracellular space,nucleus,cytoplasm,focal adhesion,actin cytoskeleton,membrane,nuclear matrix,filopodium,growth cone,extracellular matrix,lamellipodium membrane,mitochondrial membrane,vesicle,ruffle membrane,neuronal cell body,dendritic spine,extracellular exosomeI>sp|P23528|COF1_HUMAN Cofilin-1 OS=Ho< mo sapiens OX=9606 GN=CFL1 PE=1 SV=3P25786PSMA1 PSA1_HUMANProteasome subunit alpha type-1MAPK cascade,protein polyubiquitination,stimulatory C-type lectin receptor signaling pathway,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent,regulation of cellular amino acid metabolic process,negative regulation of G2/M transition of mitotic cell cycle,protein deubiquitination,anaphase-promoting complex-dependent catabolic process,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process,tumor necrosis factor-mediated signaling pathway,NIK/NF-kappaB signaling,Fc-epsilon receptor signaling pathway,proteasome-mediated ubiquitin-dependent protein catabolic process,regulation of mRNA stability,T cell receptor signaling pathway,negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition,transmembrane transport,Wnt signaling pathway, planar cell polarity pathway,regulation of transcription from RNA polymerase II promoter in response to hypoxia,negative regulation of canonical Wnt signaling pathway,positive regulation of canonical Wnt signaling pathwayARNA binding,threonine-type endopeptidase activity,protein bindingproteasome complex,nucleus,nucleoplasm,centrosome,cytosol,proteasome core complex,polysome,proteasome core complex, alpha-subunit complex,extracellular exosome`>sp|P25786|PSA1_HUMAN Proteasome subunit alpha type-1 OS=Homo sapiens OX=9606 GN=PSMA1 PE=1 SV=1Q12906ILF3 ILF3_HUMAN%Interleukin enhancer-binding factor 3 transcription, DNA-templated,protein phosphorylation,negative regulation of translation,negative regulation of viral genome replication,negative regulation of transcription, DNA-templated,positive regulation of transcription, DNA-templated,defense response to virusCDNA binding,RNA binding,double-stranded RNA binding,protein bindingfnucleus,nucleoplasm,nucleolus,cytoplasm,mitochondrion,membrane,intracellular ribonucleoprotein complexe>sp|Q12906|ILF3_HUMAN Interleukin enhancer-binding factor 3 OS=Homo sapiens OX=9606 GN=ILF3 PE=1 SV=3Q9ULV4CORO1C COR1C_HUMAN Coronin-1Cneural crest cell migration,regulation of protein phosphorylation,negative regulation of protein phosphorylation,phagocytosis,signal transduction,regulation of epithelial cell migration,negative regulation of epithelial cell migration,regulation of fibroblast migration,actin cytoskeleton organization,negative regulation of protein kinase activity by regulation of protein phosphorylation,establishment of protein localization,regulation of focal adhesion assembly,negative regulation of focal adhesion assembly,activation of GTPase activity,regulation of substrate adhesion-dependent cell spreading,negative regulation of substrate adhesion-dependent cell spreading,regulation of ruffle assembly,positive regulation of lamellipodium morphogenesis9protein binding,Rac GTPase binding,actin filament bindingkcytoplasm,focal adhesion,actin cytoskeleton,lateral plasma membrane,flotillin complex,lamellipodium,vesicleM>sp|Q9ULV4|COR1C_HUMAN Coronin-1C OS=Homo sapiens OX=9606 GN=CORO1C PE=1 SV=1O43175PHGDH SERA_HUMAN"D-3-phosphoglycerate dehydrogenasexglutamine metabolic process,glycine metabolic process,L-serine biosynthetic process,threonine metabolic process,brain development,gamma-aminobutyric acid metabolic process,regulation of gene expression,taurine metabolic process,spinal cord development,glial cell development,neural tube development,neuron projection development,oxidation-reduction process,G1 to G0 transitionMphosphoglycerate dehydrogenase activity,electron carrier activity,NAD binding+cytosol,myelin sheath,extracellular exosomec>sp|O43175|SERA_HUMAN D-3-phosphoglycerate dehydrogenase OS=Homo sapiens OX=9606 GN=PHGDH PE=1 SV=4Q9H0U4RAB1B RAB1B_HUMANRas-related protein Rab-1BPER to Golgi vesicle-mediated transport,retrograde vesicle-mediated transport, Golgi to ER,autophagy,small GTPase mediated signal transduction,protein transport,virion assembly,COPII vesicle coating,positive regulation of glycoprotein metabolic process,regulation of autophagosome assembly,establishment of endothelial intestinal barrierGolgi membrane,mitochondrion,endoplasmic reticulum membrane,Golgi apparatus,cytosol,transport vesicle,endoplasmic reticulum-Golgi intermediate compartment membrane,pre-autophagosomal structure membrane,extracellular exosome\>sp|Q9H0U4|RAB1B_HUMAN Ras-related protein Rab-1B OS=Homo sapiens OX=9606 GN=RAB1B PE=1 SV=1O75351VPS4B VPS4B_HUMAN.Vacuolar protein sorting-associated protein 4Bcell separation after cytokinesis,potassium ion transport,nucleus organization,vacuole organization,mitotic metaphase plate congression,regulation of centrosome duplication,positive regulation of G2/M transition of mitotic cell cycle,protein transport,endosomal transport,macroautophagy,viral life cycle,viral release from host cell,cholesterol transport,endosome to lysosome transport via multivesicular body sorting pathway,response to lipid,multivesicular body assembly,viral budding via host ESCRT complex,ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway,positive regulation of viral process,regulation of viral process,protein depolymerization,negative regulation of cell death,late endosomal microautophagy,ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway,regulation of mitotic spindle assembly,positive regulation of viral release from host cell,negative regulation of exosomal secretion,positive regulation of exosomal secretion,positive regulation of centriole elongation,positive regulation of viral life cycle,ESCRT III complex disassembly,cytoplasmic microtubule organizationprotein binding,ATP binding,protein C-terminus binding,ATPase activity,ATPase activity, coupled,identical protein binding,protein homodimerization activity,microtubule-severing ATPase activityspindle pole,nucleus,cytoplasm,endosome,centrosome,cytosol,endosome membrane,late endosome membrane,extracellular exosome,Flemming bodyp>sp|O75351|VPS4B_HUMAN Vacuolar protein sorting-associated protein 4B OS=Homo sapiens OX=9606 GN=VPS4B PE=1 SV=2O15427SLC16A3 MOT4_HUMANMonocarboxylate transporter 4npyruvate metabolic process,monocarboxylic acid transport,plasma membrane lactate transport,leukocyte migrationRNA binding,protein binding,monocarboxylic acid transmembrane transporter activity,lactate transmembrane transporter activity,symporter activityOplasma membrane,integral component of plasma membrane,membrane,nuclear membrane`>sp|O15427|MOT4_HUMAN Monocarboxylate transporter 4 OS=Homo sapiens OX=9606 GN=SLC16A3 PE=1 SV=1Q8NBS9TXNDC5 TXND5_HUMAN'Thioredoxin domain-containing protein 5protein folding,response to endoplasmic reticulum stress,negative regulation of apoptotic process,apoptotic cell clearance,neutrophil degranulation,cell redox homeostasis4protein disulfide isomerase activity,protein bindingextracellular region,endoplasmic reticulum,endoplasmic reticulum lumen,azurophil granule lumen,lysosomal lumen,extracellular exosomej>sp|Q8NBS9|TXND5_HUMAN Thioredoxin domain-containing protein 5 OS=Homo sapiens OX=9606 GN=TXNDC5 PE=1 SV=2P22626 HNRNPA2B1 ROA2_HUMAN.Heterogeneous nuclear ribonucleoproteins A2/B1{negative regulation of transcription from RNA polymerase II promoter,mRNA splicing, via spliceosome,mRNA processing,mRNA export from nucleus,gene expression,primary miRNA processing,G-quadruplex DNA unwinding,negative regulation of mRNA splicing, via spliceosome,RNA transport,positive regulation of telomere maintenance via telomere lengthening,Requires Ontology,miRNA transportnucleotide binding,RNA binding,mRNA 3'-UTR binding,protein binding,miRNA binding,single-stranded telomeric DNA binding,pre-mRNA intronic binding,G-rich strand telomeric DNA binding,N6-methyladenosine-containing RNA bindingchromosome, telomeric region,nucleus,nucleoplasm,spliceosomal complex,cytoplasm,Cajal body,membrane,nuclear matrix,intracellul< ar ribonucleoprotein complex,extracellular exosome,catalytic step 2 spliceosomes>sp|P22626|ROA2_HUMAN Heterogeneous nuclear ribonucleoproteins A2/B1 OS=Homo sapiens OX=9606 GN=HNRNPA2B1 PE=1 SV=2O60716CTNND1 CTND1_HUMANCatenin delta-1transcription, DNA-templated,regulation of transcription, DNA-templated,cell adhesion,brain development,Wnt signaling pathway,single organismal cell-cell adhesion,adherens junction organization,entry of bacterium into host cell,negative regulation of canonical Wnt signaling pathwayHreceptor binding,protein binding,protein kinase binding,cadherin bindingnucleus,cytoplasm,cytosol,plasma membrane,cell-cell junction,zonula adherens,lamellipodium,growth cone,midbody,dendritic spine,extracellular exosomeR>sp|O60716|CTND1_HUMAN Catenin delta-1 OS=Homo sapiens OX=9606 GN=CTNND1 PE=1 SV=1P27824CANX CALX_HUMANCalnexinHantigen processing and presentation of peptide antigen via MHC class I,protein folding,aging,protein secretion,antigen processing and presentation of exogenous peptide antigen via MHC class II,protein folding in endoplasmic reticulum,synaptic vesicle endocytosis,chaperone-mediated protein folding,clathrin-dependent endocytosisglycoprotein binding,RNA binding,calcium ion binding,protein binding,carbohydrate binding,apolipoprotein binding,ionotropic glutamate receptor binding,unfolded protein bindingendoplasmic reticulum,endoplasmic reticulum lumen,endoplasmic reticulum membrane,smooth endoplasmic reticulum,rough endoplasmic reticulum,ribosome,membrane,axon,extracellular matrix,dendrite cytoplasm,melanosome,neuronal cell body,dendritic spine,myelin sheath,protein complex,ER-mitochondrion membrane contact site,extracellular exosome,integral component of lumenal side of endoplasmic reticulum membraneH>sp|P27824|CALX_HUMAN Calnexin OS=Homo sapiens OX=9606 GN=CANX PE=1 SV=2O43790KRT86 KRT86_HUMANKeratin, type II cuticular Hb6keratinization,cornificationBextracellular space,cytosol,keratin filament,extracellular exosome`>sp|O43790|KRT86_HUMAN Keratin, type II cuticular Hb6 OS=Homo sapiens OX=9606 GN=KRT86 PE=1 SV=1Q16851UGP2 UGPA_HUMAN,UTP--glucose-1-phosphate uridylyltransferaseglycogen metabolic process,glycogen biosynthetic process,UDP-glucose metabolic process,UDP-glucuronate biosynthetic process,glucose 1-phosphate metabolic processUTP:glucose-1-phosphate uridylyltransferase activity,protein binding,glucose binding,pyrimidine ribonucleotide binding,identical protein binding,metal ion binding/nucleus,cytoplasm,cytosol,extracellular exosomel>sp|Q16851|UGPA_HUMAN UTP--glucose-1-phosphate uridylyltransferase OS=Homo sapiens OX=9606 GN=UGP2 PE=1 SV=5P47756CAPZB CAPZB_HUMAN$F-actin-capping protein subunit betamovement of cell or subcellular component,cytoskeleton organization,blood coagulation,regulation of lamellipodium assembly,regulation of cell morphogenesis,actin cytoskeleton organization,barbed-end actin filament capping,negative regulation of filopodium assembly5actin binding,cadherin binding,actin filament bindingcytosol,cytoskeleton,actin filament,F-actin capping protein complex,actin cytoskeleton,sarcomere,extracellular exosome,WASH complexf>sp|P47756|CAPZB_HUMAN F-actin-capping protein subunit beta OS=Homo sapiens OX=9606 GN=CAPZB PE=1 SV=4Q9Y281CFL2 COF2_HUMAN Cofilin-2skeletal muscle tissue development,actin filament depolymerization,actin filament fragmentation,positive regulation of actin filament depolymerization,sarcomere organization,muscle cell cellular homeostasisYextracellular space,actin cytoskeleton,nuclear matrix,Z disc,I band,extracellular exosomeI>sp|Q9Y281|COF2_HUMAN Cofilin-2 OS=Homo sapiens OX=9606 GN=CFL2 PE=1 SV=1O43852CALU CALU_HUMAN Calumeninextracellular region,endoplasmic reticulum,endoplasmic reticulum membrane,Golgi apparatus,membrane,sarcoplasmic reticulum lumen,melanosomeI>sp|O43852|CALU_HUMAN Calumenin OS=Homo sapiens OX=9606 GN=CALU PE=1 SV=2Q9UKU6TRHDE TRHDE_HUMAN2Thyrotropin-releasing hormone-degrading ectoenzymejproteolysis,signal transduction,cell-cell signaling,regulation of blood pressure,peptide catabolic processWaminopeptidase activity,zinc ion binding,peptide binding,metalloaminopeptidase activityEcytoplasm,integral component of plasma membrane,extracellular exosomet>sp|Q9UKU6|TRHDE_HUMAN Thyrotropin-releasing hormone-degrading ectoenzyme OS=Homo sapiens OX=9606 GN=TRHDE PE=2 SV=1P52907CAPZA1 CAZA1_HUMAN'F-actin-capping protein subunit alpha-1extracellular region,cytosol,cytoskeleton,F-actin capping protein complex,actin cytoskeleton,extracellular exosome,WASH complexj>sp|P52907|CAZA1_HUMAN F-actin-capping protein subunit alpha-1 OS=Homo sapiens OX=9606 GN=CAPZA1 PE=1 SV=3P62873GNB1 GBB1_HUMAN@Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1protein folding,signal transduction,adenylate cyclase-activating dopamine receptor signaling pathway,phospholipase C-activating G-protein coupled receptor signaling pathway,positive regulation of cytosolic calcium ion concentration,G-protein coupled acetylcholine receptor signaling pathway,Wnt signaling pathway, calcium modulating pathway,Ras protein signal transduction,cell proliferation,cardiac muscle cell apoptotic process,rhodopsin mediated signaling pathway,platelet activation,sensory perception of taste,retina development in camera-type eye,protein heterotrimerization,cellular response to glucagon stimulus,cellular response to prostaglandin E stimulus,cellular response to hypoxia,cellular response to catecholamine stimulusGTPase activity,signal transducer activity,protein binding,spectrin binding,type 1 angiotensin receptor binding,protein complex binding,alkylglycerophosphoethanolamine phosphodiesterase activity,GTPase binding photoreceptor inner segment,intracellular,lysosomal membrane,cytosol,heterotrimeric G-protein complex,plasma membrane,membrane,dendrite,photoreceptor outer segment membrane,myelin sheath,cell body,extracellular exosome,photoreceptor disc membrane,extracellular vesicle>sp|P62873|GBB1_HUMAN Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 OS=Homo sapiens OX=9606 GN=GNB1 PE=1 SV=3Q6NZI2CAVIN1 CAVN1_HUMANCaveolae-associated protein 1regulation of transcription, DNA-templated,transcription initiation from RNA polymerase I promoter,termination of RNA polymerase I transcription;RNA binding,protein binding,rRNA primary transcript bindingnucleus,nucleoplasm,cytoplasm,mitochondrion,endoplasmic reticulum,cytosol,plasma membrane,caveola,intracellular membrane-bounded organelle,protein complex,membrane raft`>sp|Q6NZI2|CAVN1_HUMAN Caveolae-associated protein 1 OS=Homo sapiens OX=9606 GN=CAVIN1 PE=1 SV=1P62979RPS27A RS27A_HUMAN$Ubiquitin-40S ribosomal protein S27aUG2/M transition of mitotic cell cycle,negative regulation of transcription from RNA polymerase II promoter,MAPK cascade,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,activation of MAPK activity,protein polyubiquitination,nucleotide-excision repair, DNA damage recognition,nucleotide-excision repair, DNA duplex unwinding,stimulatory C-type lectin receptor signaling pathway,MyD88-dependent toll-like receptor signaling pathway,MyD88-independent toll-like receptor signaling pathway,glycogen biosynthetic process,transcription-coupled nucleotide-excision repair,nucleotide-excision repair, preincision complex assembly,nucleotide-excision repair, DNA incision, 5'-to lesion,nucleotide-excision repair, DNA gap filling,rRNA processing,translation,translational initiation,protein folding,SRP-dependent cotranslational protein targeting to membrane,DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest,transforming growth factor beta receptor signaling pathway,Notch signaling pathway,I-kappaB kinase/NF-kappaB signaling,JNK cascade,fibroblast growth factor receptor signaling pathway,regulation of tumor necrosis factor-mediated signaling pathway,negative regulation of G2/M transition of mitotic cell cycle,Wnt signaling pathway,endosomal transport,macroautophagy,protein ubiquitination,protei< n deubiquitination,viral life cycle,virion assembly,viral transcription,translesion synthesis,negative regulation of transforming growth factor beta receptor signaling pathway,anaphase-promoting complex-dependent catabolic process,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process,regulation of type I interferon production,negative regulation of type I interferon production,tumor necrosis factor-mediated signaling pathway,nucleotide-excision repair, DNA incision,ion transmembrane transport,entry of bacterium into host cell,TRIF-dependent toll-like receptor signaling pathway,interstrand cross-link repair,NIK/NF-kappaB signaling,Fc-epsilon receptor signaling pathway,ERBB2 signaling pathway,negative regulation of epidermal growth factor receptor signaling pathway,error-prone translesion synthesis,DNA damage response, detection of DNA damage,protein ubiquitination involved in ubiquitin-dependent protein catabolic process,positive regulation of apoptotic process,negative regulation of apoptotic process,positive regulation of I-kappaB kinase/NF-kappaB signaling,proteasome-mediated ubiquitin-dependent protein catabolic process,regulation of mRNA stability,cellular protein metabolic process,innate immune response,positive regulation of epidermal growth factor receptor signaling pathway,positive regulation of transcription from RNA polymerase II promoter,T cell receptor signaling pathway,positive regulation of NF-kappaB transcription factor activity,stress-activated MAPK cascade,negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition,transmembrane transport,Wnt signaling pathway, planar cell polarity pathway,regulation of necroptotic process,membrane organization,regulation of transcription from RNA polymerase II promoter in response to hypoxia,nucleotide-binding oligomerization domain containing signaling pathway,global genome nucleotide-excision repair,error-free translesion synthesis,intracellular transport of virus,negative regulation of canonical Wnt signaling pathway,positive regulation of canonical Wnt signaling pathway,regulation of signal transduction by p53 class mediator,endoplasmic reticulum mannose trimmingPRNA binding,structural constituent of ribosome,protein binding,metal ion binding6extracellular space,nucleus,nucleoplasm,nucleolus,cytoplasm,mitochondrial outer membrane,cytosol,plasma membrane,endosome membrane,small ribosomal subunit,membrane,cytosolic small ribosomal subunit,endocytic vesicle membrane,myelin sheath,endoplasmic reticulum quality control compartment,extracellular exosomeg>sp|P62979|RS27A_HUMAN Ubiquitin-40S ribosomal protein S27a OS=Homo sapiens OX=9606 GN=RPS27A PE=1 SV=2O60506SYNCRIP HNRPQ_HUMAN)Heterogeneous nuclear ribonucleoprotein QmRNA splicing, via spliceosome,osteoblast differentiation,RNA processing,RNA splicing,viral process,negative regulation of translation,CRD-mediated mRNA stabilization,cellular response to interferon-gamma>nucleotide binding,RNA binding,protein binding,poly(A) bindingnucleus,nucleoplasm,endoplasmic reticulum,membrane,intracellular ribonucleoprotein complex,CRD-mediated mRNA stability complex,catalytic step 2 spliceosome,histone pre-mRNA 3'end processing complex,GAIT complexm>sp|O60506|HNRPQ_HUMAN Heterogeneous nuclear ribonucleoprotein Q OS=Homo sapiens OX=9606 GN=SYNCRIP PE=1 SV=2O00186STXBP3 STXB3_HUMANSyntaxin-binding protein 3vesicle docking involved in exocytosis,brain development,glucose transport,protein to membrane docking,insulin secretion,response to insulin,neutrophil degranulation,negative regulation of calcium ion-dependent exocytosis,protein heterooligomerization,platelet aggregation3protein binding,syntaxin-1 binding,syntaxin bindingcytosol,plasma membrane,basolateral plasma membrane,apical plasma membrane,platelet alpha granule,specific granule,extracellular exosome,tertiary granule]>sp|O00186|STXB3_HUMAN Syntaxin-binding protein 3 OS=Homo sapiens OX=9606 GN=STXBP3 PE=1 SV=2P26639TARS1 SYTC_HUMAN%Threonine--tRNA ligase 1, cytoplasmicTtranslation,tRNA aminoacylation for protein translation,threonyl-tRNA aminoacylation\threonine-tRNA ligase activity,protein binding,ATP binding,protein homodimerization activity:cytoplasm,cytosol,actin cytoskeleton,extracellular exosomef>sp|P26639|SYTC_HUMAN Threonine--tRNA ligase 1, cytoplasmic OS=Homo sapiens OX=9606 GN=TARS1 PE=1 SV=3P15121AKR1B1 ALDR_HUMAN&Aldo-keto reductase family 1 member B1*tissue homeostasis,renal water homeostasis,carbohydrate metabolic process,sorbitol biosynthetic process,C21-steroid hormone biosynthetic process,response to stress,response to water deprivation,naphthalene metabolic process,stress-activated protein kinase signaling cascade,regulation of urine volume,norepinephrine metabolic process,negative regulation of apoptotic process,daunorubicin metabolic process,doxorubicin metabolic process,fructose biosynthetic process,positive regulation of JAK-STAT cascade,positive regulation of smooth muscle cell proliferation,oxidation-reduction process,maternal process involved in female pregnancy,cellular response to hydrogen peroxide,inner medullary collecting duct development,response to thyroid hormone,cellular response to methylglyoxal,cellular response to peptidealditol:NADP+ 1-oxidoreductase activity,aldo-keto reductase (NADP) activity,electron carrier activity,glyceraldehyde oxidoreductase activityextracellular space,nucleoplasm,cytosol,cell projection cytoplasm,paranodal junction,mast cell granule,Schmidt-Lanterman incisure,perinuclear region of cytoplasm,extracellular exosome,Schwann cell microvillush>sp|P15121|ALDR_HUMAN Aldo-keto reductase family 1 member B1 OS=Homo sapiens OX=9606 GN=AKR1B1 PE=1 SV=3Q8NBJ5COLGALT1 GT251_HUMAN#Procollagen galactosyltransferase 1*procollagen galactosyltransferase activity$endoplasmic reticulum lumen,membraneh>sp|Q8NBJ5|GT251_HUMAN Procollagen galactosyltransferase 1 OS=Homo sapiens OX=9606 GN=COLGALT1 PE=1 SV=1O95782AP2A1 AP2A1_HUMANAP-2 complex subunit alpha-1intracellular protein transport,Golgi to endosome transport,endocytosis,receptor-mediated endocytosis,microtubule-based movement,antigen processing and presentation of exogenous peptide antigen via MHC class II,ephrin receptor signaling pathway,regulation of defense response to virus by virus,Wnt signaling pathway, planar cell polarity pathway,membrane organization,clathrin-dependent endocytosis,negative regulation of hyaluronan biosynthetic processprotein binding,protein C-terminus binding,protein transporter activity,protein kinase binding,protein complex binding,clathrin adaptor activitycytosol,plasma membrane,membrane,basolateral plasma membrane,apical plasma membrane,AP-2 adaptor complex,clathrin coat of trans-Golgi network vesicle,endocytic vesicle membrane,clathrin-coated endocytic vesicle membrane,filopodium tip,endolysosome membrane^>sp|O95782|AP2A1_HUMAN AP-2 complex subunit alpha-1 OS=Homo sapiens OX=9606 GN=AP2A1 PE=1 SV=3Q16531DDB1 DDB1_HUMANDNA damage-binding protein 1)nucleotide-excision repair, DNA damage recognition,nucleotide-excision repair, DNA duplex unwinding,DNA repair,transcription-coupled nucleotide-excision repair,nucleotide-excision repair,nucleotide-excision repair, preincision complex stabilization,nucleotide-excision repair, preincision complex assembly,nucleotide-excision repair, DNA incision, 3'-to lesion,nucleotide-excision repair, DNA incision, 5'-to lesion,viral process,Wnt signaling pathway,nucleotide-excision repair, DNA incision,histone H2A monoubiquitination,DNA damage response, detection of DNA damage,protein ubiquitination involved in ubiquitin-dependent protein catabolic process,negative regulation of apoptotic process,proteasome-mediated ubiquitin-dependent protein catabolic process,positive regulation of viral genome replication,positive regulation by virus of viral protein levels in host cell,interaction with symbiont,global genome nucleotide-excision repair,UV-damage excision repair,regulation of mi< totic cell cycle phase transition,positive regulation of viral release from host cell/DNA binding,protein binding,damaged DNA bindingnuclear chromosome, telomeric region,extracellular space,nucleus,nucleoplasm,cytoplasm,Cul4A-RING E3 ubiquitin ligase complex,Cul4B-RING E3 ubiquitin ligase complex,extracellular exosome,Cul4-RING E3 ubiquitin ligase complex\>sp|Q16531|DDB1_HUMAN DNA damage-binding protein 1 OS=Homo sapiens OX=9606 GN=DDB1 PE=1 SV=1P25398RPS12 RS12_HUMAN40S ribosomal protein S12>nucleoplasm,cytosol,membrane,cytosolic small ribosomal subunitZ>sp|P25398|RS12_HUMAN 40S ribosomal protein S12 OS=Homo sapiens OX=9606 GN=RPS12 PE=1 SV=3P00750PLAT TPA_HUMAN!Tissue-type plasminogen activatorresponse to hypoxia,cellular protein modification process,proteolysis,blood coagulation,smooth muscle cell migration,plasminogen activation,fibrinolysis,negative regulation of proteolysis,platelet-derived growth factor receptor signaling pathwayoglycoprotein binding,serine-type endopeptidase activity,receptor binding,protein binding,phosphoprotein bindingextracellular region,extracellular space,cytoplasm,cell surface,secretory granule,apical part of cell,extracellular exosome,extracellular matrix`>sp|P00750|TPA_HUMAN Tissue-type plasminogen activator OS=Homo sapiens OX=9606 GN=PLAT PE=1 SV=1P01137TGFB1 TGFB1_HUMAN,Transforming growth factor beta-1 proprotein8protein import into nucleus, translocation,negative regulation of transcription from RNA polymerase II promoter,MAPK cascade,vasculogenesis,ureteric bud development,response to hypoxia,epithelial to mesenchymal transition,neural tube closure,negative regulation of protein phosphorylation,positive regulation of protein phosphorylation,regulation of sodium ion transport,chondrocyte differentiation,hematopoietic progenitor cell differentiation,connective tissue replacement involved in inflammatory response wound healing,adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains,tolerance induction to self antigen,platelet degranulation,heart valve morphogenesis,protein phosphorylation,protein export from nucleus,ATP biosynthetic process,phosphate-containing compound metabolic process,cellular calcium ion homeostasis,inflammatory response,cell cycle arrest,mitotic cell cycle checkpoint,epidermal growth factor receptor signaling pathway,transforming growth factor beta receptor signaling pathway,common-partner SMAD protein phosphorylation,SMAD protein complex assembly,SMAD protein import into nucleus,Notch signaling pathway,negative regulation of neuroblast proliferation,salivary gland morphogenesis,endoderm development,heart development,female pregnancy,aging,negative regulation of DNA replication,positive regulation of cell proliferation,negative regulation of cell proliferation,germ cell migration,response to wounding,response to glucose,defense response to fungus, incompatible interaction,positive regulation of vascular endothelial growth factor production,positive regulation of gene expression,negative regulation of gene expression,negative regulation of extracellular matrix disassembly,positive regulation of epithelial to mesenchymal transition,macrophage derived foam cell differentiation,positive regulation of fibroblast migration,positive regulation of peptidyl-threonine phosphorylation,positive regulation of pathway-restricted SMAD protein phosphorylation,negative regulation of macrophage cytokine production,oligodendrocyte development,cell growth,regulation of striated muscle tissue development,cell migration,regulation of transforming growth factor beta receptor signaling pathway,evasion or tolerance of host defenses by virus,neural tube development,negative regulation of cell-cell adhesion,hyaluronan catabolic process,negative regulation of ossification,negative regulation of cell growth,regulation of cell migration,positive regulation of cell migration,positive regulation of bone mineralization,BMP signaling pathway,negative regulation of transforming growth factor beta receptor signaling pathway,positive regulation of histone deacetylation,membrane protein intracellular domain proteolysis,positive regulation of protein complex assembly,positive regulation of exit from mitosis,lipopolysaccharide-mediated signaling pathway,positive regulation of cellular protein metabolic process,response to estradiol,response to progesterone,regulation of interleukin-23 production,negative regulation of interleukin-17 production,positive regulation of interleukin-17 production,receptor catabolic process,positive regulation of superoxide anion generation,mononuclear cell proliferation,positive regulation of collagen biosynthetic process,positive regulation of peptidyl-serine phosphorylation,response to vitamin D,response to laminar fluid shear stress,positive regulation of histone acetylation,positive regulation of protein dephosphorylation,response to immobilization stress,negative regulation of T cell proliferation,regulation of protein import into nucleus,positive regulation of protein import into nucleus,positive regulation of odontogenesis,response to drug,myelination,regulation of apoptotic process,myeloid dendritic cell differentiation,T cell homeostasis,positive regulation of apoptotic process,positive regulation of vascular permeability,positive regulation of MAP kinase activity,protein kinase B signaling,positive regulation of blood vessel endothelial cell migration,negative regulation of blood vessel endothelial cell migration,positive regulation of phosphatidylinositol 3-kinase activity,ossification involved in bone remodeling,regulatory T cell differentiation,cell-cell junction organization,positive regulation of regulatory T cell differentiation,negative regulation of cell differentiation,negative regulation of fat cell differentiation,negative regulation of myoblast differentiation,negative regulation of cell cycle,negative regulation of transcription, DNA-templated,positive regulation of transcription, DNA-templated,negative regulation of mitotic cell cycle,positive regulation of transcription from RNA polymerase II promoter,active induction of host immune response by virus,positive regulation of fibroblast proliferation,positive regulation of isotype switching to IgA isotypes,cell development,lymph node development,digestive tract development,negative regulation of skeletal muscle tissue development,inner ear development,positive regulation of epithelial cell proliferation,negative regulation of epithelial cell proliferation,positive regulation of protein secretion,positive regulation of peptidyl-tyrosine phosphorylation,negative regulation of phagocytosis,leukocyte migration,positive regulation of chemotaxis,positive regulation of NF-kappaB transcription factor activity,regulation of binding,regulation of DNA binding,positive regulation of smooth muscle cell differentiation,negative regulation of release of sequestered calcium ion into cytosol,positive regulation of cell division,positive regulation of protein kinase B signaling,ventricular cardiac muscle tissue morphogenesis,regulation of blood vessel remodeling,face morphogenesis,frontal suture morphogenesis,pathway-restricted SMAD protein phosphorylation,regulation of SMAD protein import into nucleus,positive regulation of SMAD protein import into nucleus,SMAD protein signal transduction,mammary gland branching involved in thelarche,branch elongation involved in mammary gland duct branching,regulation of branching involved in mammary gland duct morphogenesis,negative regulation of gene silencing by miRNA,regulation of cartilage development,lens fiber cell differentiation,positive regulation of ERK1 and ERK2 cascade,response to cholesterol,positive regulation of cell cycle arrest,cellular response to mechanical stimulus,cellular response to organic cyclic compound,cellular response to ionizing radiation,cellular response to dexamethasone stimulus,cellular response to transforming growth factor beta stimulus,positive regulation of mononuclear cell migration,extracellular matrix assembly,positive regulation of branching involved in ureteric bud morph< ogenesis,extrinsic apoptotic signaling pathway,liver regeneration,negative regulation of hyaluronan biosynthetic process,positive regulation of extracellular matrix assembly,positive regulation of NAD+ ADP-ribosyltransferase activity,positive regulation of pri-miRNA transcription from RNA polymerase II promoter,negative regulation of protein localization to plasma membrane,negative regulation of production of miRNAs involved in gene silencing by miRNA,positive regulation of receptor clustering,transforming growth factor beta receptor signaling pathway involved in heart development,cellular response to insulin-like growth factor stimulus,embryonic liver development,regulation of actin cytoskeleton reorganization,positive regulation of transcription regulatory region DNA binding,positive regulation of cardiac muscle cell differentiation,regulation of epithelial to mesenchymal transition involved in endocardial cushion formationglycoprotein binding,antigen binding,type II transforming growth factor beta receptor binding,cytokine activity,transforming growth factor beta receptor binding,protein binding,growth factor activity,enzyme binding,type I transforming growth factor beta receptor binding,type III transforming growth factor beta receptor binding,protein homodimerization activity,protein serine/threonine kinase activator activity,protein heterodimerization activity,protein N-terminus bindingextracellular region,proteinaceous extracellular matrix,extracellular space,nucleus,cytoplasm,Golgi lumen,plasma membrane,cell surface,axon,extracellular matrix,platelet alpha granule lumen,neuronal cell body,blood microparticle,microvillusn>sp|P01137|TGFB1_HUMAN Transforming growth factor beta-1 proprotein OS=Homo sapiens OX=9606 GN=TGFB1 PE=1 SV=2P10644PRKAR1A KAP0_HUMAN=cAMP-dependent protein kinase type I-alpha regulatory subunitmesoderm formation,renal water homeostasis,regulation of transcription from RNA polymerase II promoter,female meiotic division,blood coagulation,activation of protein kinase A activity,intracellular signal transduction,sarcomere organization,negative regulation of meiotic nuclear division,negative regulation of activated T cell proliferation,cardiac muscle cell proliferation,cellular response to glucagon stimulus,negative regulation of cAMP-dependent protein kinase activitycytoplasm,cytosol,cAMP-dependent protein kinase complex,membrane,nucleotide-activated protein kinase complex,neuromuscular junction,protein complex,plasma membrane raft,ciliary base,immunological synapse>sp|P10644|KAP0_HUMAN cAMP-dependent protein kinase type I-alpha regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR1A PE=1 SV=1Q07960ARHGAP1 RHG01_HUMANRho GTPase-activating protein 1small GTPase mediated signal transduction,Rho protein signal transduction,positive regulation of signal transduction,positive regulation of GTPase activity,regulation of small GTPase mediated signal transductionfSH3/SH2 adaptor activity,GTPase activator activity,protein binding,SH3 domain binding,cadherin bindingGcytoplasm,cytosol,perinuclear region of cytoplasm,extracellular exosomec>sp|Q07960|RHG01_HUMAN Rho GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=ARHGAP1 PE=1 SV=1P28161GSTM2 GSTM2_HUMANGlutathione S-transferase Mu 2glutathione metabolic process,regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum,regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion,regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion,nitrobenzene metabolic process,xenobiotic catabolic process,linoleic acid metabolic process,relaxation of cardiac muscle,negative regulation of ryanodine-sensitive calcium-release channel activity,positive regulation of ryanodine-sensitive calcium-release channel activity,cellular detoxification of nitrogen compound,cellular response to caffeine,cellular oxidant detoxification,glutathione derivative biosynthetic processglutathione transferase activity,glutathione peroxidase activity,receptor binding,protein binding,enzyme binding,protein homodimerization activity,glutathione binding>cytoplasm,cytosol,sarcoplasmic reticulum,extracellular exosome`>sp|P28161|GSTM2_HUMAN Glutathione S-transferase Mu 2 OS=Homo sapiens OX=9606 GN=GSTM2 PE=1 SV=2P07910HNRNPC HNRPC_HUMAN.Heterogeneous nuclear ribonucleoproteins C1/C2mRNA splicing, via spliceosome,osteoblast differentiation,RNA splicing,gene expression,negative regulation of telomere maintenance via telomerase,ATP-dependent chromatin remodeling,3'-UTR-mediated mRNA stabilizationWnucleotide binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II distal enhancer sequence-specific DNA binding,RNA binding,mRNA 3'-UTR binding,protein binding,poly(U) RNA binding,nucleosomal DNA binding,identical protein binding,telomerase RNA binding,N6-methyladenosine-containing RNA bindingnuclear chromatin,nucleus,nucleoplasm,spliceosomal complex,cytosol,membrane,protein complex,extracellular exosome,catalytic step 2 spliceosome,telomerase holoenzyme complexq>sp|P07910|HNRPC_HUMAN Heterogeneous nuclear ribonucleoproteins C1/C2 OS=Homo sapiens OX=9606 GN=HNRNPC PE=1 SV=4P78509RELN RELN_HUMANReelincell morphogenesis involved in differentiation,neuron migration,proteolysis,cell adhesion,axon guidance,central nervous system development,brain development,long-term memory,associative learning,glial cell differentiation,positive regulation of neuron projection development,positive regulation of phosphatidylinositol 3-kinase signaling,dendrite development,peptidyl-tyrosine phosphorylation,spinal cord patterning,ventral spinal cord development,hippocampus development,cerebral cortex tangential migration,layer formation in cerebral cortex,positive regulation of TOR signaling,positive regulation of CREB transcription factor activity,protein localization to synapse,reelin-mediated signaling pathway,positive regulation of protein kinase activity,response to pain,positive regulation of peptidyl-tyrosine phosphorylation,regulation of behavior,modulation of synaptic transmission,positive regulation of small GTPase mediated signal transduction,positive regulation of synaptic transmission, glutamatergic,long-term synaptic potentiation,positive regulation of dendritic spine morphogenesis,positive regulation of protein tyrosine kinase activity,positive regulation of synapse maturation,NMDA glutamate receptor clustering,postsynaptic density protein 95 clustering,receptor localization to synapse,lateral motor column neuron migration,positive regulation of long-term synaptic potentiation,positive regulation of lateral motor column neuron migration,regulation of N-methyl-D-aspartate selective glutamate receptor activity,positive regulation of excitatory postsynaptic potential,positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activityprotein serine/threonine/tyrosine kinase activity,serine-type peptidase activity,metal ion binding,lipoprotein particle receptor binding,very-low-density lipoprotein particle receptor bindingnextracellular region,proteinaceous extracellular matrix,extracellular space,cytoplasm,plasma membrane,dendriteF>sp|P78509|RELN_HUMAN Reelin OS=Homo sapiens OX=9606 GN=RELN PE=1 SV=3P61224RAP1B RAP1B_HUMANRas-related protein Rap-1bQcell proliferation,Rap protein signal transduction,neutrophil degranulation,establishment of endothelial barrier,positive regulation of ERK1 and ERK2 cascade,cellular response to cAMP,regulation of cell junction assembly,regulation of establishment of cell polarity,negative regulation of synaptic vesicle exocytosis,microvillus assemblyOGTPase activity,protein binding,GTP binding,GDP binding,protein complex bindingintracellular,lipid particle,cytosol,plasma membrane,cell-cell junction,membrane,azurophil granule membrane,extracellular exosome,membrane raft\>sp|P61224|RAP1B_HUMAN Ras-related protein Rap-1b OS=Homo sapiens OX=9606 GN=RAP1B PE=1 SV=1O43776NARS1 SYNC_HUMAN$Asparagine--tRNA ligase, c< ytoplasmicKtRNA aminoacylation for protein translation,asparaginyl-tRNA aminoacylation@nucleic acid binding,asparagine-tRNA ligase activity,ATP binding5cytoplasm,mitochondrion,cytosol,extracellular exosomee>sp|O43776|SYNC_HUMAN Asparagine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=NARS1 PE=1 SV=1Q9UPN3MACF1 MACF1_HUMAN:Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5regulation of epithelial cell migration,Wnt signaling pathway,positive regulation of Wnt signaling pathway,regulation of microtubule-based process,wound healing,Golgi to plasma membrane protein transport,positive regulation of axon extension,regulation of focal adhesion assemblyRNA binding,actin binding,calcium ion binding,protein binding,microtubule binding,ATPase activity,cadherin binding,actin filament bindingRcytoplasm,Golgi apparatus,cytoskeleton,microtubule,plasma membrane,ruffle membrane|>sp|Q9UPN3|MACF1_HUMAN Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 OS=Homo sapiens OX=9606 GN=MACF1 PE=1 SV=4Q5VYK3ECPAS ECM29_HUMAN-Proteasome adapter and scaffold protein ECM29OER-associated ubiquitin-dependent protein catabolic process,proteasome assembly;molecular_function,protein binding,protein complex scaffoldnucleus,early endosome,late endosome,multivesicular body,endoplasmic reticulum,endoplasmic reticulum-Golgi intermediate compartment,centrosome,membrane,ER to Golgi transport vesicle,endocytic vesicle,cytoplasmic vesicle,trans-Golgi network,proteasome complexo>sp|Q5VYK3|ECM29_HUMAN Proteasome adapter and scaffold protein ECM29 OS=Homo sapiens OX=9606 GN=ECPAS PE=1 SV=2P04179SOD2 SODM_HUMAN(Superoxide dismutase [Mn], mitochondrialresponse to reactive oxygen species,response to superoxide,age-dependent response to reactive oxygen species,release of cytochrome c from mitochondria,vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure,regulation of transcription from RNA polymerase II promoter,superoxide metabolic process,regulation of blood pressure,negative regulation of cell proliferation,removal of superoxide radicals,oxygen homeostasis,negative regulation of neuron apoptotic process,protein homotetramerization,oxidation-reduction process,negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathwayMsuperoxide dismutase activity,manganese ion binding,identical protein bindingh>sp|P04179|SODM_HUMAN Superoxide dismutase [Mn], mitochondrial OS=Homo sapiens OX=9606 GN=SOD2 PE=1 SV=3O76074PDE5A PDE5A_HUMAN,cGMP-specific 3',5'-cyclic phosphodiesteraseQsignal transduction,positive regulation of cardiac muscle hypertrophy,regulation of cGMP metabolic process,negative regulation of T cell proliferation,positive regulation of MAP kinase activity,cGMP catabolic process,negative regulation of cardiac muscle contraction,relaxation of cardiac muscle,positive regulation of oocyte development}3',5'-cyclic-nucleotide phosphodiesterase activity,cGMP binding,metal ion binding,3',5'-cyclic-GMP phosphodiesterase activityn>sp|O76074|PDE5A_HUMAN cGMP-specific 3',5'-cyclic phosphodiesterase OS=Homo sapiens OX=9606 GN=PDE5A PE=1 SV=2P49747COMP COMP_HUMAN#Cartilage oligomeric matrix proteinskeletal system development,growth plate cartilage development,apoptotic process,cell adhesion,animal organ morphogenesis,extracellular matrix organization,negative regulation of apoptotic process,limb developmentprotease binding,extracellular matrix structural constituent,calcium ion binding,protein binding,collagen binding,heparin binding,heparan sulfate proteoglycan bindingc>sp|P49747|COMP_HUMAN Cartilage oligomeric matrix protein OS=Homo sapiens OX=9606 GN=COMP PE=1 SV=2Q13347EIF3I EIF3I_HUMAN4Eukaryotic translation initiation factor 3 subunit Itranslational initiation6translation initiation factor activity,protein bindingcytosol,eukaryotic translation initiation factor 3 complex,extracellular exosome,eukaryotic translation initiation factor 3 complex, eIF3mv>sp|Q13347|EIF3I_HUMAN Eukaryotic translation initiation factor 3 subunit I OS=Homo sapiens OX=9606 GN=EIF3I PE=1 SV=1P49411TUFM EFTU_HUMAN#Elongation factor Tu, mitochondrial^RNA binding,translation elongation factor activity,GTPase activity,protein binding,GTP bindingnmitochondrion,mitochondrial inner membrane,membrane,mitochondrial nucleoid,myelin sheath,extracellular exosomec>sp|P49411|EFTU_HUMAN Elongation factor Tu, mitochondrial OS=Homo sapiens OX=9606 GN=TUFM PE=1 SV=2P36952SERPINB5 SPB5_HUMAN Serpin B5morphogenesis of an epithelium,movement of cell or subcellular component,negative regulation of endopeptidase activity,extracellular matrix organization,regulation of epithelial cell proliferation,prostate gland morphogenesis<serine-type endopeptidase inhibitor activity,protein binding3extracellular space,cytoplasm,extracellular exosomeM>sp|P36952|SPB5_HUMAN Serpin B5 OS=Homo sapiens OX=9606 GN=SERPINB5 PE=1 SV=2P48556PSMD8 PSMD8_HUMAN.26S proteasome non-ATPase regulatory subunit 8MAPK cascade,protein polyubiquitination,stimulatory C-type lectin receptor signaling pathway,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent,regulation of cellular amino acid metabolic process,negative regulation of G2/M transition of mitotic cell cycle,protein deubiquitination,anaphase-promoting complex-dependent catabolic process,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process,regulation of protein stability,tumor necrosis factor-mediated signaling pathway,NIK/NF-kappaB signaling,Fc-epsilon receptor signaling pathway,proteasome-mediated ubiquitin-dependent protein catabolic process,proteasome assembly,regulation of mRNA stability,T cell receptor signaling pathway,negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition,transmembrane transport,Wnt signaling pathway, planar cell polarity pathway,regulation of transcription from RNA polymerase II promoter in response to hypoxia,negative regulation of canonical Wnt signaling pathway,positive regulation of canonical Wnt signaling pathway,positive regulation of protein targeting to mitochondrionproteasome complex,nucleus,nucleoplasm,cytosol,proteasome regulatory particle,proteasome regulatory particle, lid subcomplex,proteasome accessory complex,extracellular exosomep>sp|P48556|PSMD8_HUMAN 26S proteasome non-ATPase regulatory subunit 8 OS=Homo sapiens OX=9606 GN=PSMD8 PE=1 SV=2Q8IWA5SLC44A2 CTL2_HUMAN"Choline transporter-like protein 2phosphatidylcholine biosynthetic process,signal transduction,choline transport,positive regulation of I-kappaB kinase/NF-kappaB signaling,neutrophil degranulation,transmembrane transportEsignal transducer activity,choline transmembrane transporter activityqlysosomal membrane,plasma membrane,integral component of membrane,specific granule membrane,extracellular exosomee>sp|Q8IWA5|CTL2_HUMAN Choline transporter-like protein 2 OS=Homo sapiens OX=9606 GN=SLC44A2 PE=1 SV=3P04792HSPB1 HSPB1_HUMANHeat shock protein beta-1retina homeostasis,regulation of protein phosphorylation,regulation of translational initiation,negative regulation of protein kinase activity,movement of cell or subcellular component,response to unfolded protein,response to virus,regulation of autophagy,positive regulation of interleukin-1 beta production,intracellular signal transduction,cellular response to vascular endothelial growth factor stimulus,positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway,positive regulation of tumor necrosis factor biosynthetic process,negative regulation of apoptotic process,regulation of I-kappaB kinase/NF-kappaB signaling,regulation of mRNA stability,positive regulation of blood vessel endothelial cell migration,positive regulation of angiogenesis,vascular endothelial growth factor receptor signaling pathway,chaperone-mediated protein folding,platele< t aggregation,negative regulation of protein serine/threonine kinase activity,anterograde axonal protein transport,negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway,positive regulation of endothelial cell chemotaxisRNA binding,protein kinase C binding,protein binding,protein kinase C inhibitor activity,protein kinase binding,identical protein binding,ubiquitin binding,protein binding involved in protein foldingproteasome complex,extracellular space,nucleus,cytoplasm,spindle,cytosol,cytoskeleton,plasma membrane,focal adhesion,Z disc,extracellular matrix,extracellular exosome,axon cytoplasm[>sp|P04792|HSPB1_HUMAN Heat shock protein beta-1 OS=Homo sapiens OX=9606 GN=HSPB1 PE=1 SV=2P16278GLB1 BGAL_HUMANBeta-galactosidaseglycosaminoglycan catabolic process,glycosphingolipid metabolic process,galactose catabolic process,keratan sulfate catabolic process,neutrophil degranulation,cellular carbohydrate metabolic process\exo-alpha-sialidase activity,beta-galactosidase activity,protein binding,galactoside bindingextracellular region,extracellular space,cytoplasm,vacuole,Golgi apparatus,azurophil granule lumen,lysosomal lumen,intracellular membrane-bounded organelle,perinuclear region of cytoplasm,extracellular exosome,ficolin-1-rich granule lumenR>sp|P16278|BGAL_HUMAN Beta-galactosidase OS=Homo sapiens OX=9606 GN=GLB1 PE=1 SV=2O00203AP3B1 AP3B1_HUMANAP-3 complex subunit beta-1*protein targeting to lysosome,intracellular protein transport,blood coagulation,anterograde axonal transport,melanosome organization,antigen processing and presentation, exogenous lipid antigen via MHC class Ib,anterograde synaptic vesicle transport,positive regulation of NK T cell differentiation9protein phosphatase binding,GTP-dependent protein bindinglysosomal membrane,Golgi apparatus,membrane,AP-3 adaptor complex,clathrin adaptor complex,clathrin-coated vesicle membrane,axon cytoplasm]>sp|O00203|AP3B1_HUMAN AP-3 complex subunit beta-1 OS=Homo sapiens OX=9606 GN=AP3B1 PE=1 SV=3P63151PPP2R2A 2ABA_HUMANQSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform(G2/M transition of mitotic cell cycle,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,mitotic cell cycle,protein dephosphorylation,mitotic nuclear envelope reassembly,developmental process,response to morphine,regulation of catalytic activity,peptidyl-serine dephosphorylationprotein serine/threonine phosphatase activity,protein binding,protein phosphatase regulator activity,protein complex binding,tau protein binding,protein phosphatase 2A binding7protein phosphatase type 2A complex,nucleoplasm,cytosol>sp|P63151|2ABA_HUMAN Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R2A PE=1 SV=1P0DTE7;P0DTE8;P0DUB6AMY1B;AMY1C;AMY1A#AMY1B_HUMAN;AMY1C_HUMAN;AMY1A_HUMAN2Alpha-amylase 1B;Alpha-amylase 1C;Alpha-amylase 1A>sp|P0DTE7|AMY1B_HUMAN Alpha-amylase 1B OS=Homo sapiens OX=9606 GN=AMY1B PE=1 SV=1;>sp|P0DTE8|AMY1C_HUMAN Alpha-amylase 1C OS=Homo sapiens OX=9606 GN=AMY1C PE=1 SV=1;>sp|P0DUB6|AMY1A_HUMAN Alpha-amylase 1A OS=Homo sapiens OX=9606 GN=AMY1A PE=1 SV=1Q9ULI3HEG1 HEG1_HUMANProtein HEG homolog 1vasculogenesis,in utero embryonic development,endothelial cell morphogenesis,lymph vessel development,lymph circulation,cardiac atrium morphogenesis,ventricular trabecula myocardium morphogenesis,ventricular septum development,cell-cell junction assembly,post-embryonic development,lung development,multicellular organism growth,venous blood vessel morphogenesis,regulation of body fluid levels,cardiac muscle tissue growth,pericardium development,positive regulation of fibroblast growth factor productiongextracellular region,cell-cell junction,external side of plasma membrane,integral component of membraneU>sp|Q9ULI3|HEG1_HUMAN Protein HEG homolog 1 OS=Homo sapiens OX=9606 GN=HEG1 PE=1 SV=3P46063RECQL RECQ1_HUMANATP-dependent DNA helicase Q1odouble-strand break repair via homologous recombination,DNA strand renaturation,DNA repair,DNA duplex unwindingDNA binding,DNA helicase activity,ATP-dependent DNA helicase activity,protein binding,ATP binding,four-way junction helicase activity,annealing helicase activity,ATP-dependent 3'-5' DNA helicase activity1nucleus,nucleoplasm,chromosome,cytoplasm,membrane_>sp|P46063|RECQ1_HUMAN ATP-dependent DNA helicase Q1 OS=Homo sapiens OX=9606 GN=RECQL PE=1 SV=3P18124RPL7 RL7_HUMAN60S ribosomal protein L7\nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA),cytoplasmic translation,rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,viral transcription,ribosomal large subunit biogenesisyDNA binding,RNA binding,mRNA binding,structural constituent of ribosome,protein binding,protein homodimerization activitynucleus,nucleolus,cytoplasm,cytosol,polysome,focal adhesion,membrane,cytosolic large ribosomal subunit,intracellular ribonucleoprotein complex,extracellular exosomeW>sp|P18124|RL7_HUMAN 60S ribosomal protein L7 OS=Homo sapiens OX=9606 GN=RPL7 PE=1 SV=1Q9Y285FARSA SYFA_HUMAN(Phenylalanine--tRNA ligase alpha subunitjtRNA aminoacylation for protein translation,phenylalanyl-tRNA aminoacylation,protein heterotetramerizationWtRNA binding,RNA binding,phenylalanine-tRNA ligase activity,protein binding,ATP bindingi>sp|Q9Y285|SYFA_HUMAN Phenylalanine--tRNA ligase alpha subunit OS=Homo sapiens OX=9606 GN=FARSA PE=1 SV=3P63010AP2B1 AP2B1_HUMANAP-2 complex subunit betaventricular septum development,intracellular protein transport,receptor-mediated endocytosis,microtubule-based movement,antigen processing and presentation of exogenous peptide antigen via MHC class II,aorta development,ephrin receptor signaling pathway,clathrin coat assembly,regulation of defense response to virus by virus,Wnt signaling pathway, planar cell polarity pathway,coronary vasculature development,membrane organization,clathrin-dependent endocytosis,neurotransmitter receptor internalizationsignal sequence binding,protein binding,protein transporter activity,clathrin binding,protein complex binding,clathrin adaptor activitytrans-Golgi network,cytosol,plasma membrane,membrane,AP-2 adaptor complex,endocytic vesicle membrane,clathrin-coated endocytic vesicle membrane,endolysosome membrane[>sp|P63010|AP2B1_HUMAN AP-2 complex subunit beta OS=Homo sapiens OX=9606 GN=AP2B1 PE=1 SV=1Q99988GDF15 GDF15_HUMAN Growth/differentiation factor 15Ssignal transduction,transforming growth factor beta receptor signaling pathway,cell-cell signaling,positive regulation of pathway-restricted SMAD protein phosphorylation,BMP signaling pathway,regulation of apoptotic process,regulation of MAPK cascade,cell development,SMAD protein signal transduction,positive regulation of myoblast fusionicytokine activity,transforming growth factor beta receptor binding,protein binding,growth factor activityPextracellular region,extracellular space,nucleus,cytoplasm,extracellular exosomeb>sp|Q99988|GDF15_HUMAN Growth/differentiation factor 15 OS=Homo sapiens OX=9606 GN=GDF15 PE=1 SV=3A0AVT1UBA6 UBA6_HUMAN+Ubiquitin-like modifier-activating enzyme 6ubiquitin-dependent protein catabolic process,learning,locomotory behavior,protein ubiquitination,amygdala development,hippocampus development,protein ubiquitination involved in ubiquitin-dependent protein catabolic process,dendritic spine developmentaubiquitin activating enzyme activity,protein binding,ATP binding,FAT10 activating enzyme activitycytoplasm,cytosolk>sp|A0AVT1|UBA6_HUMAN Ubiquitin-like modifier-activating enzyme 6 OS=Homo sapiens OX=9606 GN=UBA6 PE=1 SV=1P35613BSG BASI_HUMANBasiginnpyruvate metabolic process,cell surface receptor signaling pathway,embryo implantation,monocarboxylic acid transport,extracellular matrix disassembly,extracellular matrix organization,odontogenesis of dentin-containing tooth,response to peptide hormone< ,response to mercury ion,decidualization,leukocyte migration,response to cAMP,protein targeting to plasma membranegprotein binding,mannose binding,monocarboxylic acid transmembrane transporter activity,cadherin bindingGolgi membrane,acrosomal membrane,mitochondrion,plasma membrane,integral component of plasma membrane,focal adhesion,membrane,sarcolemma,melanosome,intracellular membrane-bounded organelle,membrane raft,extracellular exosomeF>sp|P35613|BASI_HUMAN Basigin OS=Homo sapiens OX=9606 GN=BSG PE=1 SV=2Q07866KLC1 KLC1_HUMANKinesin light chain 1intracellular protein transport,retrograde vesicle-mediated transport, Golgi to ER,microtubule-based movement,viral process,antigen processing and presentation of exogenous peptide antigen via MHC class II,protein localization to synapse,stress granule disassemblyImotor activity,microtubule motor activity,protein binding,tubulin bindingdcytosol,kinesin complex,microtubule,membrane,axon,growth cone,cytoplasmic vesicle,neuronal cell bodyU>sp|Q07866|KLC1_HUMAN Kinesin light chain 1 OS=Homo sapiens OX=9606 GN=KLC1 PE=1 SV=2O14617AP3D1 AP3D1_HUMANAP-3 complex subunit delta-1eye pigment biosynthetic process,intracellular protein transport,anterograde axonal transport,synaptic vesicle budding from endosome,melanosome organization,endosome to melanosome transport,antigen processing and presentation, exogenous lipid antigen via MHC class Ib,anterograde synaptic vesicle transport,synaptic vesicle membrane organization,positive regulation of NK T cell differentiation,regulation of sequestering of zinc ion,protein localization to membrane,neurotransmitter receptor transport, postsynaptic endosome to lysosometransporter activityGolgi membrane,lysosomal membrane,Golgi apparatus,endosome membrane,membrane,AP-3 adaptor complex,terminal bouton,presynaptic endosome,axon cytoplasm^>sp|O14617|AP3D1_HUMAN AP-3 complex subunit delta-1 OS=Homo sapiens OX=9606 GN=AP3D1 PE=1 SV=1P21796VDAC1 VDAC1_HUMAN3Voltage-dependent anion-selective channel protein 1kbehavioral fear response,anion transport,mitochondrial calcium ion transport,apoptotic process,neuron-neuron synaptic transmission,learning,viral process,macroautophagy,epithelial cell differentiation,anion transmembrane transport,regulation of mitophagy,regulation of anion transmembrane transport,negative regulation of reactive oxygen species metabolic processprotein binding,voltage-gated anion channel activity,porin activity,protein kinase binding,protein complex binding,ion channel bindingnucleus,mitochondrion,mitochondrial outer membrane,mitochondrial inner membrane,plasma membrane,synaptic vesicle,membrane,mitochondrial nucleoid,myelin sheath,membrane raft,pore complex,extracellular exosomeu>sp|P21796|VDAC1_HUMAN Voltage-dependent anion-selective channel protein 1 OS=Homo sapiens OX=9606 GN=VDAC1 PE=1 SV=2P61163ACTR1A ACTZ_HUMANAlpha-centractinG2/M transition of mitotic cell cycle,spermatogenesis,vesicle-mediated transport,antigen processing and presentation of exogenous peptide antigen via MHC class II,ciliary basal body docking ATP bindingmanchette,cytoplasm,centrosome,centriole,cytosol,dynactin complex,microtubule associated complex,microtubule cytoskeleton,COPI-coated vesicle,myelin sheath,extracellular exosomeR>sp|P61163|ACTZ_HUMAN Alpha-centractin OS=Homo sapiens OX=9606 GN=ACTR1A PE=1 SV=1P68032ACTC1 ACTC_HUMANActin, alpha cardiac muscle 1apoptotic process,positive regulation of gene expression,actin filament-based movement,muscle filament sliding,skeletal muscle thin filament assembly,actomyosin structure organization,actin-myosin filament sliding,response to drug,negative regulation of apoptotic process,response to ethanol,cardiac myofibril assembly,cardiac muscle tissue morphogenesis,heart contraction,cardiac muscle contraction,mesenchyme migration*ATP binding,ATPase activity,myosin bindingextracellular space,cytoplasm,cytosol,actin filament,focal adhesion,membrane,sarcomere,lamellipodium,filopodium,I band,actomyosin, actin portion,cell body,extracellular exosome,blood microparticle^>sp|P68032|ACTC_HUMAN Actin, alpha cardiac muscle 1 OS=Homo sapiens OX=9606 GN=ACTC1 PE=1 SV=1P51665PSMD7 PSMD7_HUMAN.26S proteasome non-ATPase regulatory subunit 7MAPK cascade,protein polyubiquitination,stimulatory C-type lectin receptor signaling pathway,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent,regulation of cellular amino acid metabolic process,negative regulation of G2/M transition of mitotic cell cycle,protein deubiquitination,anaphase-promoting complex-dependent catabolic process,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process,tumor necrosis factor-mediated signaling pathway,NIK/NF-kappaB signaling,Fc-epsilon receptor signaling pathway,proteasome-mediated ubiquitin-dependent protein catabolic process,neutrophil degranulation,regulation of mRNA stability,T cell receptor signaling pathway,negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition,transmembrane transport,Wnt signaling pathway, planar cell polarity pathway,regulation of transcription from RNA polymerase II promoter in response to hypoxia,negative regulation of canonical Wnt signaling pathway,positive regulation of canonical Wnt signaling pathway1protein binding,protein homodimerization activityproteasome complex,extracellular region,nucleus,nucleoplasm,cytosol,proteasome regulatory particle,membrane,secretory granule lumen,extracellular exosome,ficolin-1-rich granule lumenp>sp|P51665|PSMD7_HUMAN 26S proteasome non-ATPase regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PSMD7 PE=1 SV=2P00734F2 THRB_HUMAN Prothrombinpositive regulation of protein phosphorylation,signal peptide processing,proteolysis,ER to Golgi vesicle-mediated transport,acute-phase response,cell surface receptor signaling pathway,multicellular organism development,blood coagulation,blood coagulation, intrinsic pathway,positive regulation of cell proliferation,regulation of cell shape,response to wounding,regulation of gene expression,negative regulation of platelet activation,positive regulation of phosphatidylinositol 3-kinase signaling,peptidyl-glutamic acid carboxylation,platelet activation,regulation of blood coagulation,positive regulation of blood coagulation,positive regulation of cell growth,positive regulation of collagen biosynthetic process,fibrinolysis,cellular protein metabolic process,negative regulation of proteolysis,negative regulation of astrocyte differentiation,leukocyte migration,positive regulation of release of sequestered calcium ion into cytosol,regulation of cytosolic calcium ion concentration,negative regulation of fibrinolysis,positive regulation of lipid kinase activity,positive regulation of protein localization to nucleus,positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway,positive regulation of reactive oxygen species metabolic processserine-type endopeptidase activity,receptor binding,calcium ion binding,protein binding,growth factor activity,thrombospondin receptor activityextracellular region,extracellular space,endoplasmic reticulum lumen,Golgi lumen,plasma membrane,extracellular exosome,blood microparticleI>sp|P00734|THRB_HUMAN Prothrombin OS=Homo sapiens OX=9606 GN=F2 PE=1 SV=2P09936UCHL1 UCHL1_HUMAN0Ubiquitin carboxyl-terminal hydrolase isozyme L1uresponse to ischemia,axon target recognition,adult walking behavior,cell proliferation,regulation of macroautophagy,protein deubiquitination,sensory perception of pain,axonal transport of mitochondrion,eating behavior,proteasome-mediated ubiquitin-dependent protein catabolic process,negative regulation of MAP kinase activity,muscle fiber development,neuromuscular processcysteine-type endopeptidase activity,thiol-dependent ubiquitin-specific protease activity,protein binding,omega peptidase activity,ligase activity,ubiquitin protein ligase binding,alpha-2A adrenergic r< eceptor binding,thiol-dependent ubiquitinyl hydrolase activity,ubiquitin bindingnucleoplasm,cytoplasm,endoplasmic reticulum membrane,cytosol,neuronal cell body,myelin sheath,neuron projection terminus,extracellular exosome,axon cytoplasm,plasma membraner>sp|P09936|UCHL1_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L1 OS=Homo sapiens OX=9606 GN=UCHL1 PE=1 SV=2 P63092;Q5JWF2GNASGNAS2_HUMAN;GNAS1_HUMANGuanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas;tissue homeostasis,endochondral ossification,energy reserve metabolic process,DNA methylation,adenylate cyclase-activating G-protein coupled receptor signaling pathway,adenylate cyclase-activating dopamine receptor signaling pathway,sensory perception of chemical stimulus,embryonic hindlimb morphogenesis,multicellular organism growth,post-embryonic body morphogenesis,response to drug,positive regulation of osteoblast differentiation,positive regulation of osteoclast differentiation,developmental growth,embryonic cranial skeleton morphogenesis,cognition,cartilage development,bone development,hair follicle placode formation,platelet aggregation,genetic imprinting,regulation of parathyroid hormone secretionk;GTPase activity,signal transducer activity,insulin-like growth factor receptor binding,protein binding,GTP binding,G-protein beta/gamma-subunit complex binding,beta-2 adrenergic receptor binding,D1 dopamine receptor binding,mu-type opioid receptor binding,ionotropic glutamate receptor binding,metal ion binding,corticotropin-releasing hormone receptor 1 bindingh;cytosol,heterotrimeric G-protein complex,membrane,apical plasma membrane,dendrite,extracellular exosome >sp|P63092|GNAS2_HUMAN Guanine nucleotide-binding protein G(s) subunit alpha isoforms short OS=Homo sapiens OX=9606 GN=GNAS PE=1 SV=1;>sp|Q5JWF2|GNAS1_HUMAN Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas OS=Homo sapiens OX=9606 GN=GNAS PE=1 SV=2P61106RAB14 RAB14_HUMANRas-related protein Rab-14phosphatidylinositol biosynthetic process,Golgi to endosome transport,small GTPase mediated signal transduction,fibroblast growth factor receptor signaling pathway,embryo development,protein transport,vesicle-mediated transport,regulation of endocytosis,endocytic recycling,regulation of protein localization,defense response to bacterium,neutrophil degranulation,intracellular transport,membrane organization,phagosome maturationHGTPase activity,protein binding,GTP binding,GDP binding,myosin V bindingGolgi membrane,intracellular,lysosome,lysosomal membrane,early endosome,late endosome,rough endoplasmic reticulum,Golgi stack,trans-Golgi network,cytosol,plasma membrane,trans-Golgi network transport vesicle,cytoplasmic vesicle membrane,early endosome membrane,nuclear outer membrane-endoplasmic reticulum membrane network,intracellular membrane-bounded organelle,phagocytic vesicle,perinuclear region of cytoplasm,recycling endosome,recycling endosome membrane,extracellular exosome,tertiary granule membrane,cilium\>sp|P61106|RAB14_HUMAN Ras-related protein Rab-14 OS=Homo sapiens OX=9606 GN=RAB14 PE=1 SV=4O75131CPNE3 CPNE3_HUMANCopine-3protein phosphorylation,lipid metabolic process,vesicle-mediated transport,positive regulation of cell migration,ERBB2 signaling pathway,neutrophil degranulation,glycerophospholipid biosynthetic process,cellular response to calcium ion,cellular response to growth factor stimulusRNA binding,protein serine/threonine kinase activity,transporter activity,protein binding,calcium-dependent phospholipid binding,receptor tyrosine kinase binding,calcium-dependent protein bindingnucleus,nucleolus,cytoplasm,mitochondrion,cytosol,plasma membrane,focal adhesion,cell junction,azurophil granule membrane,extracellular exosomeJ>sp|O75131|CPNE3_HUMAN Copine-3 OS=Homo sapiens OX=9606 GN=CPNE3 PE=1 SV=1P35580MYH10 MYH10_HUMAN Myosin-10mitotic cytokinesis,in utero embryonic development,neuron migration,plasma membrane repair,cardiac septum development,exocytosis,substrate-dependent cell migration, cell extension,nuclear migration,cell adhesion,axon guidance,adult heart development,cell proliferation,regulation of cell shape,fourth ventricle development,lateral ventricle development,third ventricle development,cerebellar Purkinje cell layer development,actin filament-based movement,actomyosin structure organization,aorta development,neuromuscular process controlling balance,cardiac myofibril assembly,ventricular cardiac muscle cell development,retina development in camera-type eye,coronary vasculature development,modification of postsynaptic actin cytoskeletonmicrofilament motor activity,actin binding,protein binding,calmodulin binding,ATP binding,actin-dependent ATPase activity,ADP binding,actin filament bindingstress fiber,nucleus,cytoplasm,spindle,cytosol,plasma membrane,brush border,cell cortex,myosin complex,myosin II complex,lamellipodium,axon,growth cone,midbody,neuromuscular junction,cleavage furrow,actomyosin,neuronal cell body,dendritic spine,extracellular exosome,myosin II filamentK>sp|P35580|MYH10_HUMAN Myosin-10 OS=Homo sapiens OX=9606 GN=MYH10 PE=1 SV=3Q99816TSG101 TS101_HUMAN%Tumor susceptibility gene 101 proteinregulation of cell growth,protein monoubiquitination,cell cycle arrest,negative regulation of cell proliferation,endosome to lysosome transport,protein transport,endosomal transport,macroautophagy,viral life cycle,keratinocyte differentiation,multivesicular body assembly,viral budding via host ESCRT complex,negative regulation of epidermal growth factor receptor signaling pathway,ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway,regulation of MAP kinase activity,negative regulation of transcription, DNA-templated,viral budding,positive regulation of viral process,cell division,intracellular transport of virus,autophagosome maturation,positive regulation of viral release from host cell,positive regulation of exosomal secretion,regulation of extracellular exosome assembly,regulation of viral budding via host ESCRT complex,positive regulation of viral budding via host ESCRT complex,exosomal secretion,positive regulation of ubiquitin-dependent endocytosis,regulation of viral release from host cell DNA binding,transcription corepressor activity,protein binding,ligand-dependent nuclear receptor transcription coactivator activity,ubiquitin protein ligase binding,protein homodimerization activity,ubiquitin binding,virion binding,calcium-dependent protein bindingESCRT I complex,nucleolus,cytoplasm,endosome,early endosome,late endosome,multivesicular body,cytosol,plasma membrane,endosome membrane,late endosome membrane,extracellular exosomeh>sp|Q99816|TS101_HUMAN Tumor susceptibility gene 101 protein OS=Homo sapiens OX=9606 GN=TSG101 PE=1 SV=2P63000RAC1 RAC1_HUMAN*Ras-related C3 botulinum toxin substrate 1% positive regulation of protein phosphorylation,auditory receptor cell morphogenesis,mast cell chemotaxis,epithelial cell morphogenesis,movement of cell or subcellular component,inflammatory response,hyperosmotic response,cell adhesion,cell-matrix adhesion,G-protein coupled receptor signaling pathway,axon guidance,blood coagulation,cell proliferation,regulation of cell size,response to wounding,anatomical structure morphogenesis,regulation of hydrogen peroxide metabolic process,positive regulation of lamellipodium assembly,regulation of fibroblast migration,positive regulation of cell-substrate adhesion,regulation of neuron maturation,Rac protein signal transduction,cerebral cortex radially oriented cell migration,embryonic olfactory bulb interneuron precursor migration,cerebral cortex GABAergic interneuron development,lamellipodium assembly,actin cytoskeleton organization,actin filament polymerization,platelet activation,regulation of cell migration,positive regulation of actin filament polymerization,T cell costimulation,ruffle organization,negative regulation of interleukin-23 production,substrate adhesion-dependent cell spreading,positive regulation of Rho protein signal transduction,intr< acellular signal transduction,Fc-epsilon receptor signaling pathway,Fc-gamma receptor signaling pathway involved in phagocytosis,positive regulation of apoptotic process,neutrophil degranulation,positive regulation of phosphatidylinositol 3-kinase activity,engulfment of apoptotic cell,cell-cell junction organization,bone resorption,positive regulation of DNA replication,vascular endothelial growth factor receptor signaling pathway,ephrin receptor signaling pathway,regulation of neuronal synaptic plasticity,negative regulation of receptor-mediated endocytosis,anatomical structure arrangement,dendrite morphogenesis,cell motility,homeostasis of number of cells within a tissue,regulation of defense response to virus by virus,regulation of small GTPase mediated signal transduction,positive regulation of stress fiber assembly,localization within membrane,positive regulation of focal adhesion assembly,synaptic transmission, GABAergic,Wnt signaling pathway, planar cell polarity pathway,regulation of respiratory burst,positive regulation of dendritic spine development,cellular response to mechanical stimulus,semaphorin-plexin signaling pathway,protein localization to plasma membrane,positive regulation of neutrophil chemotaxis,cochlea morphogenesis,ruffle assembly,positive regulation of substrate adhesion-dependent cell spreading,midbrain dopaminergic neuron differentiationGTPase activity,protein binding,GTP binding,Rab GTPase binding,enzyme binding,protein kinase binding,GTP-dependent protein binding,thioesterase binding,histone deacetylase binding,Rho GDP-dissociation inhibitor binding,ATPase bindingGolgi membrane,pericentriolar material,phagocytic cup,nucleus,cytoplasm,endoplasmic reticulum membrane,trans-Golgi network,cytosol,plasma membrane,focal adhesion,membrane,extrinsic component of plasma membrane,lamellipodium,secretory granule membrane,extracellular matrix,early endosome membrane,ruffle membrane,cytoplasmic ribonucleoprotein granule,melanosome,dendritic spine,kinocilium,extracellular exosome,ficolin-1-rich granule membrane,actin filamentj>sp|P63000|RAC1_HUMAN Ras-related C3 botulinum toxin substrate 1 OS=Homo sapiens OX=9606 GN=RAC1 PE=1 SV=1Q96CG8CTHRC1 CTHR1_HUMAN1Collagen triple helix repeat-containing protein 1cell migration,positive regulation of protein binding,positive regulation of osteoblast proliferation,ossification involved in bone remodeling,positive regulation of osteoblast differentiation,Wnt signaling pathway, planar cell polarity pathway,inner ear receptor stereocilium organization,negative regulation of canonical Wnt signaling pathway,cochlea morphogenesis,establishment of planar polarity involved in neural tube closure$frizzled binding,Wnt-protein bindingPproteinaceous extracellular matrix,collagen trimer,extracellular space,cytoplasmt>sp|Q96CG8|CTHR1_HUMAN Collagen triple helix repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=CTHRC1 PE=1 SV=1Q96CW1AP2M1 AP2M1_HUMANAP-2 complex subunit muintracellular protein transport,receptor-mediated endocytosis,microtubule-based movement,antigen processing and presentation of exogenous peptide antigen via MHC class II,ephrin receptor signaling pathway,regulation of defense response to virus by virus,Wnt signaling pathway, planar cell polarity pathway,membrane organization,clathrin-dependent endocytosis,negative regulation of protein localization to plasma membranesignal sequence binding,transporter activity,protein binding,lipid binding,ion channel binding,low-density lipoprotein particle receptor binding,clathrin adaptor activitylysosomal membrane,cytosol,plasma membrane,AP-2 adaptor complex,endocytic vesicle membrane,clathrin-coated endocytic vesicle membrane,endolysosome membrane,extracellular exosomeY>sp|Q96CW1|AP2M1_HUMAN AP-2 complex subunit mu OS=Homo sapiens OX=9606 GN=AP2M1 PE=1 SV=2P28066PSMA5 PSA5_HUMANProteasome subunit alpha type-5proteasome complex,extracellular region,nucleus,nucleoplasm,cytosol,proteasome core complex,proteasome core complex, alpha-subunit complex,secretory granule lumen,extracellular exosome,ficolin-1-rich granule lumen`>sp|P28066|PSA5_HUMAN Proteasome subunit alpha type-5 OS=Homo sapiens OX=9606 GN=PSMA5 PE=1 SV=3P25705ATP5F1A ATPA_HUMAN)ATP synthase subunit alpha, mitochondrialnegative regulation of endothelial cell proliferation,lipid metabolic process,ATP biosynthetic process,embryo development,mitochondrial ATP synthesis coupled proton transport,Requires OntologyRNA binding,protein binding,ATP binding,transmembrane transporter activity,MHC class I protein binding,proton-transporting ATP synthase activity, rotational mechanism,ATPase activitymitochondrion,mitochondrial inner membrane,mitochondrial proton-transporting ATP synthase complex,mitochondrial matrix,plasma membrane,membrane,extracellular matrix,myelin sheath,proton-transporting ATP synthase complex, catalytic core F(1),extracellular exosome,COP9 signalosomel>sp|P25705|ATPA_HUMAN ATP synthase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1A PE=1 SV=1P13489RNH1 RINI_HUMANRibonuclease inhibitor[mRNA catabolic process,negative regulation of catalytic activity,regulation of angiogenesis/protein binding,ribonuclease inhibitor activity@nucleoplasm,cytosol,angiogenin-PRI complex,extracellular exosomeV>sp|P13489|RINI_HUMAN Ribonuclease inhibitor OS=Homo sapiens OX=9606 GN=RNH1 PE=1 SV=2P61978HNRNPK HNRPK_HUMAN)Heterogeneous nuclear ribonucleoprotein KmRNA splicing, via spliceosome,transcription from RNA polymerase II promoter,RNA processing,signal transduction,gene expression,regulation of low-density lipoprotein particle clearance,viral process,negative regulation of apoptotic process,positive regulation of low-density lipoprotein particle receptor biosynthetic process,positive regulation of transcription from RNA polymerase II promoter,negative regulation of mRNA splicing, via spliceosome,positive regulation of receptor-mediated endocytosis,regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter,regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorRNA polymerase II core promoter proximal region sequence-specific DNA binding,transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding,single-stranded DNA binding,RNA binding,protein binding,cadherin bindingnuclear chromatin,podosome,nucleus,nucleoplasm,cytoplasm,focal adhesion,membrane,extracellular matrix,cell projection,extracellular exosome,catalytic step 2 spliceosomel>sp|P61978|HNRPK_HUMAN Heterogeneous nuclear ribonucleoprotein K OS=Homo sapiens OX=9606 GN=HNRNPK PE=1 SV=1P17812CTPS1 PYRG1_HUMANCTP synthase 1nucleobase-containing compound metabolic process,CTP biosynthetic process,glutamine metabolic process,nucleobase-containing small molecule interconversion,T cell proliferation,B cell proliferation,response to drug,'de novo' CTP biosynthetic process;CTP synthase activity,ATP binding,identical protein bindingcytosol,membraneP>sp|P17812|PYRG1_HUMAN CTP synthase 1 OS=Homo sapiens OX=9606 GN=CTPS1 PE=1 SV=2Q9Y3F4STRAP STRAP_HUMAN3Serine-threonine kinase receptor-associated proteinnegative regulation of transcription from RNA polymerase II promoter,spliceosomal snRNP assembly,negative regulation of epithelial cell migration,negative regulation of epithelial to mesenchymal transition,maintenance of gastrointestinal epithelium,negative regulation of transforming growth factor beta receptor signaling pathway,negative regulation of epithelial cell proliferation,negative regulation of pathway-restricted SMAD protein phosphorylation,RNA binding,receptor binding,protein binding@nucleoplasm,cytoplasm,cytosol,SMN complex,SMN-Sm protein complexu>sp|Q9Y3F4|STRAP_HUMAN Serine-threonine kinase receptor-associated protein OS=Homo sapiens OX=9606 GN=STRAP PE=1 SV=1P30622CLIP1 CLIP1_HUMAN*CAP-Gly domain-containing linker protein 1microtubule bundle formation,sister chromatid cohesion,mitotic nuclear division,positive regulation of microtubule polym< erization,protein transport into plasma membrane raftprotein binding,microtubule binding,zinc ion binding,tubulin binding,protein homodimerization activity,metal ion binding,microtubule plus-end bindingkinetochore,ruffle,nuclear envelope,endosome,centrosome,cytosol,microtubule,cytoplasmic microtubule,intermediate filament,microtubule cytoskeleton,cytoplasmic vesicle membrane,microtubule plus-end,macropinosomel>sp|P30622|CLIP1_HUMAN CAP-Gly domain-containing linker protein 1 OS=Homo sapiens OX=9606 GN=CLIP1 PE=1 SV=2P04040CAT CATA_HUMANCatalase^response to reactive oxygen species,osteoblast differentiation,ureteric bud development,response to hypoxia,purine nucleotide catabolic process,triglyceride metabolic process,aging,cholesterol metabolic process,aerobic respiration,response to light intensity,UV protection,response to ozone,response to lead ion,positive regulation of phosphatidylinositol 3-kinase signaling,response to activity,response to inactivity,hemoglobin metabolic process,negative regulation of NF-kappaB transcription factor activity,response to estradiol,response to insulin,response to vitamin A,response to vitamin E,response to L-ascorbic acid,response to drug,response to hydrogen peroxide,hydrogen peroxide catabolic process,negative regulation of apoptotic process,neutrophil degranulation,response to ethanol,response to cadmium ion,positive regulation of NF-kappaB transcription factor activity,protein tetramerization,protein homotetramerization,positive regulation of cell division,response to hyperoxia,response to fatty acid,cellular response to growth factor stimulus,response to phenylpropanoid,cellular oxidant detoxificationaminoacylase activity,catalase activity,receptor binding,antioxidant activity,oxidoreductase activity, acting on peroxide as acceptor,enzyme binding,heme binding,protein homodimerization activity,metal ion binding,NADP binding^extracellular region,extracellular space,mitochondrion,mitochondrial intermembrane space,lysosome,peroxisome,peroxisomal membrane,peroxisomal matrix,endoplasmic reticulum,Golgi apparatus,cytosol,plasma membrane,focal adhesion,membrane,secretory granule lumen,intracellular membrane-bounded organelle,extracellular exosome,ficolin-1-rich granule lumenG>sp|P04040|CATA_HUMAN Catalase OS=Homo sapiens OX=9606 GN=CAT PE=1 SV=3O60664PLIN3 PLIN3_HUMAN Perilipin-3vesicle-mediated transport protein binding,cadherin bindingfcytoplasm,endosome,Golgi apparatus,lipid particle,cytosol,endosome membrane,membrane,transport vesicleM>sp|O60664|PLIN3_HUMAN Perilipin-3 OS=Homo sapiens OX=9606 GN=PLIN3 PE=1 SV=3O75165DNAJC13 DJC13_HUMAN"DnaJ homolog subfamily C member 13osteoblast differentiation,endosome organization,protein transport,neutrophil degranulation,regulation of early endosome to recycling endosome transport,regulation of early endosome to late endosome transportlysosomal membrane,cytosol,plasma membrane,endosome membrane,membrane,secretory granule membrane,early endosome membrane,azurophil granule membrane,intracellular membrane-bounded organelle,extracellular exosome,WASH complexf>sp|O75165|DJC13_HUMAN DnaJ homolog subfamily C member 13 OS=Homo sapiens OX=9606 GN=DNAJC13 PE=1 SV=5Q15746MYLK MYLK_HUMAN(Myosin light chain kinase, smooth muscle/protein phosphorylation,muscle contraction,smooth muscle contraction,tonic smooth muscle contraction,positive regulation of cell migration,bleb assembly,positive regulation of calcium ion transport,aorta smooth muscle tissue morphogenesis,cellular hypotonic response,positive regulation of wound healingqactin binding,myosin light chain kinase activity,protein binding,calmodulin binding,ATP binding,metal ion bindingRstress fiber,cytoplasm,cytosol,lamellipodium,cleavage furrow,extracellular exosomeh>sp|Q15746|MYLK_HUMAN Myosin light chain kinase, smooth muscle OS=Homo sapiens OX=9606 GN=MYLK PE=1 SV=4 P61204;P84077 ARF3;ARF1ARF3_HUMAN;ARF1_HUMAN3ADP-ribosylation factor 3;ADP-ribosylation factor 1phosphatidylinositol biosynthetic process,retrograde vesicle-mediated transport, Golgi to ER,small GTPase mediated signal transduction,protein transport;regulation of receptor internalization,phosphatidylinositol biosynthetic process,cellular copper ion homeostasis,post-Golgi vesicle-mediated transport,actin filament organization,small GTPase mediated signal transduction,protein transport,antigen processing and presentation of exogenous peptide antigen via MHC class II,regulation of Arp2/3 complex-mediated actin nucleation,very-low-density lipoprotein particle assembly,positive regulation of catalytic activity,positive regulation of endocytosis,positive regulation of calcium ion-dependent exocytosis,regulation of defense response to virus by virus,positive regulation of protein secretion,Golgi to transport vesicle transport,long term synaptic depression,positive regulation of dendritic spine development,synaptic vesicle budding,dendritic spine organization,lysosomal membrane organization,positive regulation of sodium ion transmembrane transport,positive regulation of late endosome to lysosome transport,positive regulation of ER to Golgi vesicle-mediated transport,regulation of phospholipid metabolic processGTPase activity,GTP binding;magnesium ion binding,RNA binding,GTPase activity,receptor signaling protein activity,protein binding,GTP binding,GDP binding,phospholipase D activator activityTGolgi membrane,perinuclear region of cytoplasm,extracellular exosome;Golgi membrane,late endosome,peroxisomal membrane,trans-Golgi network,cytosol,plasma membrane,focal adhesion,postsynaptic density,sarcomere,COPI-coated vesicle,cell leading edge,neuron projection,postsynaptic membrane,perinuclear region of cytoplasm,extracellular exosome>sp|P61204|ARF3_HUMAN ADP-ribosylation factor 3 OS=Homo sapiens OX=9606 GN=ARF3 PE=1 SV=2;>sp|P84077|ARF1_HUMAN ADP-ribosylation factor 1 OS=Homo sapiens OX=9606 GN=ARF1 PE=1 SV=2P34897SHMT2 GLYM_HUMAN.Serine hydroxymethyltransferase, mitochondrialglycine metabolic process,L-serine metabolic process,L-serine biosynthetic process,one-carbon metabolic process,positive regulation of cell proliferation,glycine biosynthetic process from serine,response to type I interferon,tetrahydrofolate interconversion,tetrahydrofolate metabolic process,folic acid metabolic process,protein tetramerization,protein homotetramerization,protein K63-linked deubiquitinationchromatin binding,glycine hydroxymethyltransferase activity,protein binding,L-allo-threonine aldolase activity,amino acid binding,pyridoxal phosphate binding,identical protein bindingnucleus,cytoplasm,mitochondrion,mitochondrial inner membrane,mitochondrial intermembrane space,mitochondrial matrix,microtubule cytoskeleton,mitochondrial nucleoid,extracellular exosome,BRISC complexo>sp|P34897|GLYM_HUMAN Serine hydroxymethyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=SHMT2 PE=1 SV=3P30044PRDX5 PRDX5_HUMANPeroxiredoxin-5, mitochondrialresponse to reactive oxygen species,apoptotic process,inflammatory response,response to oxidative stress,negative regulation of transcription from RNA polymerase III promoter,cellular response to reactive oxygen species,negative regulation of apoptotic process,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process,cell redox homeostasis,oxidation-reduction process,cellular oxidant detoxificationRNA polymerase III regulatory region DNA binding,peroxidase activity,receptor binding,thioredoxin peroxidase activity,cysteine-type endopeptidase inhibitor activity involved in apoptotic process,protein dimerization activityextracellular space,nucleus,cytoplasm,mitochondrion,mitochondrial matrix,peroxisome,cytosol,cytoplasmic vesicle,intracellular membrane-bounded organelle,perinuclear region of cytoplasm,extracellular exosome`>sp|P30044|PRDX5_HUMAN Peroxiredoxin-5, mitochondrial OS=Homo sapiens OX=9606 GN=PRDX5 PE=1 SV=4Q13641TPBG TPBG_HUMANTrophoblast glycoprotein5cell adhesion,positive regulation of synapse assemblyHendoplasmic reticulum,integral component of plasma membrane,cell surfaceX>sp|Q13641|TPBG_H< UMAN Trophoblast glycoprotein OS=Homo sapiens OX=9606 GN=TPBG PE=1 SV=1P05067APPA4_HUMANAmyloid-beta precursor proteinrpositive regulation of protein phosphorylation,suckling behavior,platelet degranulation,mRNA polyadenylation,regulation of translation,protein phosphorylation,cellular copper ion homeostasis,endocytosis,response to oxidative stress,cell adhesion,regulation of epidermal growth factor-activated receptor activity,Notch signaling pathway,axonogenesis,learning or memory,mating behavior,locomotory behavior,axo-dendritic transport,cholesterol metabolic process,adult locomotory behavior,visual learning,cellular process,response to lead ion,negative regulation of endopeptidase activity,positive regulation of peptidase activity,positive regulation of G2/M transition of mitotic cell cycle,axon midline choice point recognition,neuron remodeling,dendrite development,extracellular matrix organization,forebrain development,neuron projection development,ionotropic glutamate receptor signaling pathway,regulation of multicellular organism growth,regulation of protein binding,cellular protein metabolic process,innate immune response,negative regulation of neuron differentiation,positive regulation of mitotic cell cycle,positive regulation of transcription from RNA polymerase II promoter,collateral sprouting in absence of injury,regulation of synapse structure or activity,synapse organization,neuromuscular process controlling balance,synaptic growth at neuromuscular junction,positive regulation of protein metabolic process,neuron apoptotic process,smooth endoplasmic reticulum calcium ion homeostasis,cellular response to cAMP,cellular response to norepinephrine stimulus,amyloid fibril formation,cellular response to nerve growth factor stimulusDNA binding,serine-type endopeptidase inhibitor activity,receptor binding,protein binding,heparin binding,peptidase activator activity,enzyme binding,identical protein binding,transition metal ion binding,PTB domain binding,growth factor receptor bindingextracellular region,extracellular space,nuclear envelope lumen,cytoplasm,endosome,smooth endoplasmic reticulum,rough endoplasmic reticulum,Golgi apparatus,Golgi lumen,cytosol,plasma membrane,integral component of plasma membrane,clathrin-coated pit,cell-cell junction,cell surface,integral component of membrane,ER to Golgi transport vesicle,axon,platelet alpha granule lumen,neuromuscular junction,endosome lumen,trans-Golgi network membrane,ciliary rootlet,terminal bouton,dendritic spine,dendritic shaft,receptor complex,main axon,membrane raft,apical part of cell,synapse,perinuclear region of cytoplasm,spindle midzone,extracellular exosome,astrocyte projection,growth cone lamellipodium,growth cone filopodium[>sp|P05067|A4_HUMAN Amyloid-beta precursor protein OS=Homo sapiens OX=9606 GN=APP PE=1 SV=3P50281MMP14 MMP14_HUMANMatrix metalloproteinase-14angiogenesis,ovarian follicle development,response to hypoxia,endothelial cell proliferation,endochondral ossification,proteolysis,response to oxidative stress,male gonad development,response to mechanical stimulus,response to hormone,positive regulation of myotube differentiation,positive regulation of peptidase activity,response to organic cyclic compound,protein processing,extracellular matrix disassembly,positive regulation of cell growth,lung development,positive regulation of cell migration,collagen catabolic process,zymogen activation,endodermal cell differentiation,chondrocyte proliferation,astrocyte cell migration,response to estrogen,positive regulation of B cell differentiation,negative regulation of Notch signaling pathway,embryonic cranial skeleton morphogenesis,branching morphogenesis of an epithelial tube,tissue remodeling,cell motility,negative regulation of focal adhesion assembly,craniofacial suture morphogenesis,Requires Ontology,response to odorantmetalloendopeptidase activity,serine-type endopeptidase activity,integrin binding,calcium ion binding,protein binding,zinc ion binding,peptidase activator activity,metalloaminopeptidase activityGolgi lumen,cytosol,plasma membrane,integral component of plasma membrane,focal adhesion,extracellular matrix,cytoplasmic vesicle,melanosome,macropinosome,intermediate filament cytoskeleton,cytoplasm]>sp|P50281|MMP14_HUMAN Matrix metalloproteinase-14 OS=Homo sapiens OX=9606 GN=MMP14 PE=1 SV=3P55060CSE1L XPO2_HUMAN Exportin-2@protein export from nucleus,apoptotic process,cell proliferationDnucleus,nucleoplasm,cytoplasm,cytosol,membrane,extracellular exosomeK>sp|P55060|XPO2_HUMAN Exportin-2 OS=Homo sapiens OX=9606 GN=CSE1L PE=1 SV=3P62826RAN RAN_HUMANGTP-binding nuclear protein Ranribosomal large subunit export from nucleus,ribosomal small subunit export from nucleus,protein import into nucleus, translocation,DNA metabolic process,tRNA export from nucleus,protein import into nucleus,protein export from nucleus,mitotic spindle organization,mitotic nuclear division,small GTPase mediated signal transduction,spermatid development,viral process,hippocampus development,actin cytoskeleton organization,androgen receptor signaling pathway,gene silencing by RNA,positive regulation of protein binding,cellular protein complex localization,pre-miRNA export from nucleus,positive regulation of transcription, DNA-templated,cell division,cellular response to mineralocorticoid stimulus,protein transmembrane transport,intracellular transport of virus,protein localization to nucleoluschromatin binding,transcription coactivator activity,RNA binding,GTPase activity,protein binding,GTP binding,GDP binding,protein domain specific binding,protein complex binding,cadherin binding,dynein intermediate chain binding,androgen receptor binding,importin-alpha family protein binding,protein transmembrane transporter activity,pre-miRNA binding,pre-miRNA transporter activitymale germ cell nucleus,manchette,nucleus,nuclear pore,nucleoplasm,nucleolus,cytoplasm,centriole,cytosol,membrane,midbody,extracellular matrix,sperm flagellum,melanosome,RNA nuclear export complex,recycling endosome,extracellular exosome,Flemming body,chromatin]>sp|P62826|RAN_HUMAN GTP-binding nuclear protein Ran OS=Homo sapiens OX=9606 GN=RAN PE=1 SV=3P49189ALDH9A1 AL9A1_HUMAN+4-trimethylaminobutyraldehyde dehydrogenasecellular aldehyde metabolic process,neurotransmitter biosynthetic process,hormone metabolic process,carnitine biosynthetic process,oxidation-reduction process3-chloroallyl aldehyde dehydrogenase activity,aldehyde dehydrogenase (NAD) activity,aminobutyraldehyde dehydrogenase activity,1-pyrroline dehydrogenase activity,4-trimethylammoniobutyraldehyde dehydrogenase activityo>sp|P49189|AL9A1_HUMAN 4-trimethylaminobutyraldehyde dehydrogenase OS=Homo sapiens OX=9606 GN=ALDH9A1 PE=1 SV=3Q9Y315DERA DEOC_HUMANDeoxyribose-phosphate aldolasepentose-phosphate shunt,deoxyribonucleotide catabolic process,carbohydrate catabolic process,neutrophil degranulation,deoxyribonucleoside catabolic process,deoxyribose phosphate catabolic process'deoxyribose-phosphate aldolase activityoextracellular region,nucleus,cytosol,secretory granule lumen,extracellular exosome,ficolin-1-rich granule lumen^>sp|Q9Y315|DEOC_HUMAN Deoxyribose-phosphate aldolase OS=Homo sapiens OX=9606 GN=DERA PE=1 SV=2P10301RRAS RRAS_HUMANRas-related protein R-Rasleukocyte differentiation,Ras protein signal transduction,negative regulation of cell migration,positive regulation of angiogenesis,regulation of protein kinase B signaling,face morphogenesis,regulation of ERK1 and ERK2 cascadeBintracellular,plasma membrane,focal adhesion,extracellular exosomeY>sp|P10301|RRAS_HUMAN Ras-related protein R-Ras OS=Homo sapiens OX=9606 GN=RRAS PE=1 SV=1P15880RPS2 RS2_HUMAN40S ribosomal protein S2nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,rRNA processing,translation,translational initiation,protein methylation,SRP-dependent cotranslational protein targeting to membrane,viral transcription,positive regulation of transferase activityRNA binding,mRNA binding,structural constituent of ribosome,protein binding,fibroblast growth factor bin< ding,enzyme binding,cadherin bindingunucleus,nucleoplasm,cytosol,focal adhesion,membrane,cytosolic small ribosomal subunit,extracellular exosome,nucleolusW>sp|P15880|RS2_HUMAN 40S ribosomal protein S2 OS=Homo sapiens OX=9606 GN=RPS2 PE=1 SV=2P06737PYGL PYGL_HUMAN"Glycogen phosphorylase, liver formglycogen metabolic process,glycogen catabolic process,5-phosphoribose 1-diphosphate biosynthetic process,glucose homeostasis,neutrophil degranulation,necroptotic processpurine nucleobase binding,protein binding,ATP binding,glucose binding,drug binding,glycogen phosphorylase activity,AMP binding,vitamin binding,pyridoxal phosphate binding,bile acid binding,protein homodimerization activityqextracellular region,cytoplasm,cytosol,secretory granule lumen,extracellular exosome,ficolin-1-rich granule lumenb>sp|P06737|PYGL_HUMAN Glycogen phosphorylase, liver form OS=Homo sapiens OX=9606 GN=PYGL PE=1 SV=4Q9UHD8SEPTIN9 SEPT9_HUMANSeptin-9ocell cycle,protein heterooligomerization,cell division,positive regulation of nonmotile primary cilium assembly~stress fiber,cytoplasm,microtubule,axoneme,actin cytoskeleton,septin complex,perinuclear region of cytoplasm,Requires OntologyL>sp|Q9UHD8|SEPT9_HUMAN Septin-9 OS=Homo sapiens OX=9606 GN=SEPTIN9 PE=1 SV=2P60842EIF4A1 IF4A1_HUMAN!Eukaryotic initiation factor 4A-Inuclear-transcribed mRNA poly(A) tail shortening,translational initiation,regulation of gene expression,RNA secondary structure unwinding,viral processRNA cap binding,RNA binding,double-stranded RNA binding,mRNA binding,translation initiation factor activity,ATP-dependent RNA helicase activity,helicase activity,protein binding,ATP binding,translation factor activity, RNA bindingcytoplasm,cytosol,membrane,eukaryotic translation initiation factor 4F complex,extracellular matrix,extracellular exosome,nucleusd>sp|P60842|IF4A1_HUMAN Eukaryotic initiation factor 4A-I OS=Homo sapiens OX=9606 GN=EIF4A1 PE=1 SV=1P49746THBS3 TSP3_HUMANThrombospondin-3ygrowth plate cartilage development,cell-matrix adhesion,ossification involved in bone maturation,bone trabecula formation#calcium ion binding,heparin binding4extracellular region,perinuclear region of cytoplasmQ>sp|P49746|TSP3_HUMAN Thrombospondin-3 OS=Homo sapiens OX=9606 GN=THBS3 PE=1 SV=1Q10567AP1B1 AP1B1_HUMANAP-1 complex subunit beta-1intracellular protein transport,determination of left/right symmetry,heart development,vesicle-mediated transport,antigen processing and presentation of exogenous peptide antigen via MHC class II,regulation of defense response to virus by virusXtransporter activity,protein binding,protein transporter activity,protein kinase bindingGolgi membrane,lysosomal membrane,Golgi apparatus,cytosol,clathrin adaptor complex,cytoplasmic vesicle membrane,clathrin-coated endocytic vesicle membrane,trans-Golgi network membrane,intracellular membrane-bounded organelle]>sp|Q10567|AP1B1_HUMAN AP-1 complex subunit beta-1 OS=Homo sapiens OX=9606 GN=AP1B1 PE=1 SV=2Q13557CAMK2D KCC2D_HUMANACalcium/calmodulin-dependent protein kinase type II subunit deltaMAPK cascade,regulation of cell growth,regulation of the force of heart contraction,regulation of membrane depolarization,regulation of transcription from RNA polymerase II promoter,protein phosphorylation,nervous system development,regulation of heart contraction,positive regulation of cardiac muscle hypertrophy,regulation of cell communication by electrical coupling,positive regulation of cardiac muscle cell apoptotic process,regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum,regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion,peptidyl-serine phosphorylation,peptidyl-threonine phosphorylation,cell differentiation,endoplasmic reticulum calcium ion homeostasis,positive regulation of GTPase activity,protein autophosphorylation,protein oligomerization,relaxation of cardiac muscle,regulation of ryanodine-sensitive calcium-release channel activity,interferon-gamma-mediated signaling pathway,regulation of cellular localization,cellular response to calcium ion,cardiac muscle cell contraction,regulation of heart rate by cardiac conduction,regulation of cardiac muscle cell action potential,regulation of cardiac muscle cell action potential involved in regulation of contraction,regulation of cellular response to heat,regulation of histone deacetylase activity,regulation of cell communication by electrical coupling involved in cardiac conduction,regulation of relaxation of cardiac muscle,negative regulation of sodium ion transmembrane transport,regulation of calcium ion transmembrane transport via high voltage-gated calcium channel,negative regulation of sodium ion transmembrane transporter activityprotein serine/threonine kinase activity,calmodulin-dependent protein kinase activity,Ras guanyl-nucleotide exchange factor activity,protein binding,calmodulin binding,ATP binding,sodium channel inhibitor activity,titin binding,protein homodimerization activity,ion channel bindingnucleus,nucleoplasm,cytoplasm,cytosol,plasma membrane,membrane,endocytic vesicle membrane,sarcoplasmic reticulum membrane,sarcolemma,neuron projection,calcium channel complex>sp|Q13557|KCC2D_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit delta OS=Homo sapiens OX=9606 GN=CAMK2D PE=1 SV=3O00429DNM1L DNM1L_HUMANDynamin-1-like proteinmitochondrial fission,release of cytochrome c from mitochondria,dynamin family protein polymerization involved in mitochondrial fission,endocytosis,mitochondrion organization,regulation of mitochondrion organization,peroxisome fission,regulation of protein oligomerization,positive regulation of apoptotic process,positive regulation of GTPase activity,mitochondrial fragmentation involved in apoptotic process,intracellular distribution of mitochondria,positive regulation of protein secretion,protein oligomerization,protein homotetramerization,heart contraction,positive regulation of dendritic spine morphogenesis,membrane fusion,necroptotic process,mitochondrion morphogenesis,protein localization to mitochondrion,positive regulation of mitochondrial fission,mitochondrial membrane fission,positive regulation of release of cytochrome c from mitochondria,cellular response to oxygen-glucose deprivation,execution phase of apoptosis,regulation of peroxisome organization,regulation of mitophagy,regulation of ATP metabolic process,cellular response to thapsigargin,response to flavonoid,response to hypobaric hypoxia,positive regulation of intrinsic apoptotic signaling pathway,endoplasmic reticulum organizationGTPase activity,GTPase activator activity,protein binding,GTP binding,microtubule binding,lipid binding,Rab GTPase binding,GTP-dependent protein binding,ubiquitin protein ligase binding,protein homodimerization activitypGolgi membrane,cytoplasm,mitochondrion,mitochondrial outer membrane,peroxisome,endoplasmic reticulum,endoplasmic reticulum membrane,Golgi apparatus,cytosol,brush border,clathrin-coated pit,membrane,cell junction,synaptic vesicle membrane,intracellular membrane-bounded organelle,protein complex,perinuclear region of cytoplasm,microtubule,mitochondrion-derived vesicleX>sp|O00429|DNM1L_HUMAN Dynamin-1-like protein OS=Homo sapiens OX=9606 GN=DNM1L PE=1 SV=2O15143ARPC1B ARC1B_HUMAN,Actin-related protein 2/3 complex subunit 1Bmovement of cell or subcellular component,response to estradiol,Arp2/3 complex-mediated actin nucleation,Fc-gamma receptor signaling pathway involved in phagocytosis,response to estrogen,ephrin receptor signaling pathway=structural constituent of cytoskeleton,actin filament bindingkcytosol,Arp2/3 protein complex,focal adhesion,actin cytoskeleton,tubulobulbar complex,extracellular exosomeo>sp|O15143|ARC1B_HUMAN Actin-related protein 2/3 complex subunit 1B OS=Homo sapiens OX=9606 GN=ARPC1B PE=1 SV=3P50570DNM2 DYN2_HUMAN Dynamin-2G2/M transition of mitotic cell cycle,mitochondrial fission,G-protein coupled receptor internalization,ventricular septum development,dynamin family protein polymerization involv< ed in mitochondrial fission,regulation of transcription, DNA-templated,Golgi to plasma membrane transport,endocytosis,receptor-mediated endocytosis,phagocytosis,signal transduction,spermatogenesis,response to light stimulus,positive regulation of lamellipodium assembly,antigen processing and presentation of exogenous peptide antigen via MHC class II,negative regulation of transforming growth factor beta receptor signaling pathway,regulation of axon extension,receptor internalization,transferrin transport,regulation of Rac protein signal transduction,aorta development,response to cocaine,positive regulation of apoptotic process,macropinocytosis,positive regulation of nitric oxide biosynthetic process,positive regulation of transcription, DNA-templated,synaptic vesicle transport,neuron projection morphogenesis,positive regulation of phagocytosis,regulation of nitric-oxide synthase activity,coronary vasculature development,membrane organization,membrane fusion,cellular response to carbon monoxide,cellular response to X-ray,cellular response to nitric oxide,positive regulation of substrate adhesion-dependent cell spreading,negative regulation of nonmotile primary cilium assembly,cellular response to dopamine,regulation of Golgi organization,positive regulation of sodium:potassium-exchanging ATPase activity,negative regulation of membrane tubulationGTPase activity,protein binding,GTP binding,microtubule binding,SH3 domain binding,enzyme binding,protein kinase binding,D2 dopamine receptor binding,protein complex binding,phosphatidylinositol 3-kinase regulatory subunit binding,WW domain binding,nitric-oxide synthase bindingGolgi membrane,phagocytic cup,photoreceptor inner segment,nucleus,endosome,Golgi apparatus,trans-Golgi network,centrosome,cytosol,microtubule,plasma membrane,clathrin-coated pit,focal adhesion,postsynaptic density,lamellipodium,midbody,endocytic vesicle membrane,phagocytic vesicle membrane,mitochondrial membrane,ruffle membrane,protein complex,postsynaptic membrane,clathrin-coated endocytic vesicle,perinuclear region of cytoplasm,extracellular exosome,growth coneI>sp|P50570|DYN2_HUMAN Dynamin-2 OS=Homo sapiens OX=9606 GN=DNM2 PE=1 SV=2P21810BGN PGS1_HUMANBiglycanblood vessel remodeling,negative regulation of protein kinase activity,biological_process,cytokine-mediated signaling pathway,peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan,extracellular matrix organization,glycosaminoglycan metabolic process,chondroitin sulfate biosynthetic process,chondroitin sulfate catabolic process,dermatan sulfate biosynthetic process,negative regulation of JAK-STAT cascadeprotein kinase inhibitor activity,extracellular matrix structural constituent,glycosaminoglycan binding,extracellular matrix bindingextracellular region,proteinaceous extracellular matrix,extracellular space,cytoplasm,Golgi lumen,cell surface,transport vesicle,sarcolemma,lysosomal lumen,extracellular exosome,extracellular matrixG>sp|P21810|PGS1_HUMAN Biglycan OS=Homo sapiens OX=9606 GN=BGN PE=1 SV=2O95084PRSS23 PRS23_HUMANSerine protease 23"serine-type endopeptidase activity1extracellular space,nucleus,extracellular exosomeU>sp|O95084|PRS23_HUMAN Serine protease 23 OS=Homo sapiens OX=9606 GN=PRSS23 PE=1 SV=1Q14240EIF4A2 IF4A2_HUMAN"Eukaryotic initiation factor 4A-IInuclear-transcribed mRNA poly(A) tail shortening,translational initiation,regulation of translational initiation,regulation of gene expression,RNA secondary structure unwinding,viral process,negative regulation of RNA-directed RNA polymerase activityRNA binding,translation initiation factor activity,ATP-dependent RNA helicase activity,helicase activity,protein binding,ATP binding,ATPase activity[cytosol,eukaryotic translation initiation factor 4F complex,perinuclear region of cytoplasme>sp|Q14240|IF4A2_HUMAN Eukaryotic initiation factor 4A-II OS=Homo sapiens OX=9606 GN=EIF4A2 PE=1 SV=2P30419NMT1 NMT1_HUMAN*Glycylpeptide N-tetradecanoyltransferase 1 in utero embryonic development,N-terminal protein myristoylation,N-terminal peptidyl-glycine N-myristoylation,regulation of rhodopsin mediated signaling pathway,positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayOglycylpeptide N-tetradecanoyltransferase activity,myristoyltransferase activityOcytoplasm,mitochondrion,cytosol,plasma membrane,extrinsic component of membranej>sp|P30419|NMT1_HUMAN Glycylpeptide N-tetradecanoyltransferase 1 OS=Homo sapiens OX=9606 GN=NMT1 PE=1 SV=2Q9UBP4DKK3 DKK3_HUMANDickkopf-related protein 3anatomical structure morphogenesis,Wnt signaling pathway,regulation of transforming growth factor beta receptor signaling pathway,adrenal gland development,negative regulation of aldosterone biosynthetic process,negative regulation of transcription, DNA-templated,negative regulation of canonical Wnt signaling pathway,negative regulation of anti-Mullerian hormone signaling pathway,negative regulation of cortisol biosynthetic processextracellular spaceZ>sp|Q9UBP4|DKK3_HUMAN Dickkopf-related protein 3 OS=Homo sapiens OX=9606 GN=DKK3 PE=1 SV=2P40939HADHA ECHA_HUMAN1Trifunctional enzyme subunit alpha, mitochondrial`fatty acid beta-oxidation,response to insulin,cardiolipin acyl-chain remodeling,response to drugfatty-acyl-CoA binding,3-hydroxyacyl-CoA dehydrogenase activity,acetyl-CoA C-acetyltransferase activity,enoyl-CoA hydratase activity,protein binding,long-chain-enoyl-CoA hydratase activity,long-chain-3-hydroxyacyl-CoA dehydrogenase activity,protein complex binding,NAD bindingmitochondrion,mitochondrial inner membrane,mitochondrial fatty acid beta-oxidation multienzyme complex,extracellular matrix,mitochondrial nucleoidr>sp|P40939|ECHA_HUMAN Trifunctional enzyme subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=HADHA PE=1 SV=2P62241RPS8 RS8_HUMAN40S ribosomal protein S8!nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA),rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,viral transcriptionnucleus,nucleoplasm,endoplasmic reticulum,cytosol,focal adhesion,membrane,cytosolic small ribosomal subunit,intracellular ribonucleoprotein complex,extracellular exosomeW>sp|P62241|RS8_HUMAN 40S ribosomal protein S8 OS=Homo sapiens OX=9606 GN=RPS8 PE=1 SV=2P29323EPHB2 EPHB2_HUMANEphrin type-B receptor 2angiogenesis,urogenital system development,nervous system development,axon guidance,axonal fasciculation,learning,phosphorylation,peptidyl-tyrosine phosphorylation,optic nerve morphogenesis,central nervous system projection neuron axonogenesis,corpus callosum development,retinal ganglion cell axon guidance,inner ear morphogenesis,ephrin receptor signaling pathway,positive regulation of long-term neuronal synaptic plasticity,camera-type eye morphogenesis,negative regulation of axonogenesis,regulation of body fluid levels,positive regulation of synapse assembly,palate development,dendritic spine development,dendritic spine morphogenesis,commissural neuron axon guidance,trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmissionprotein tyrosine kinase activity,transmembrane-ephrin receptor activity,receptor binding,protein binding,ATP binding,axon guidance receptor activity,identical protein binding{extracellular region,nucleus,cytosol,plasma membrane,integral component of plasma membrane,axon,dendrite,neuronal cell bodyZ>sp|P29323|EPHB2_HUMAN Ephrin type-B receptor 2 OS=Homo sapiens OX=9606 GN=EPHB2 PE=1 SV=5Q93008USP9X USP9X_HUMAN4Probable ubiquitin carboxyl-terminal hydrolase FAF-Xnegative regulation of transcription from RNA polymerase II promoter,neuron migration,ubiquitin-dependent protein catabolic process,chromosome segregation,mitotic nuclear division,transforming growth factor beta receptor signaling pathway,female gamete generation,protein ubiquitination,protein deubiquitination,BMP signaling pathway,cellular protein metabolic process,axon extension,cell< divisioncysteine-type endopeptidase activity,protein binding,cysteine-type peptidase activity,thiol-dependent ubiquitinyl hydrolase activity,co-SMAD binding&cytoplasm,cytosol,membrane,growth conev>sp|Q93008|USP9X_HUMAN Probable ubiquitin carboxyl-terminal hydrolase FAF-X OS=Homo sapiens OX=9606 GN=USP9X PE=1 SV=4P35443THBS4 TSP4_HUMANThrombospondin-4positive regulation of endothelial cell proliferation,response to unfolded protein,negative regulation of angiogenesis,regulation of tissue remodeling,response to endoplasmic reticulum stress,behavioral response to pain,tissue remodeling,positive regulation of peptidyl-tyrosine phosphorylation,myoblast migration,positive regulation of cell division,endothelial cell-cell adhesion,positive regulation of neutrophil chemotaxis[integrin binding,calcium ion binding,protein binding,growth factor activity,heparin bindingextracellular region,basement membrane,extracellular space,endoplasmic reticulum,sarcoplasmic reticulum,extracellular matrix,extracellular exosomeQ>sp|P35443|TSP4_HUMAN Thrombospondin-4 OS=Homo sapiens OX=9606 GN=THBS4 PE=1 SV=2P08865RPSA RSSA_HUMAN40S ribosomal protein SA#ribosomal small subunit assembly,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA),endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA),rRNA processing,rRNA export from nucleus,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,cell adhesion,viral transcription,viral entry into host cellvirus receptor activity,RNA binding,structural constituent of ribosome,laminin receptor activity,protein binding,ribosome bindingnucleus,nucleoplasm,cytoplasm,cytosol,plasma membrane,membrane,cytosolic small ribosomal subunit,90S preribosome,extracellular exosomeX>sp|P08865|RSSA_HUMAN 40S ribosomal protein SA OS=Homo sapiens OX=9606 GN=RPSA PE=1 SV=4O95967EFEMP2 FBLN4_HUMAN:EGF-containing fibulin-like extracellular matrix protein 2Oextracellular matrix structural constituent,calcium ion binding,protein bindingRextracellular region,basement membrane,extracellular exosome,extracellular vesicle}>sp|O95967|FBLN4_HUMAN EGF-containing fibulin-like extracellular matrix protein 2 OS=Homo sapiens OX=9606 GN=EFEMP2 PE=1 SV=3P05388RPLP0 RLA0_HUMAN60S acidic ribosomal protein P0nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,viral transcription,cellular response to interleukin-4nucleus,cytoplasm,endoplasmic reticulum,cytosol,focal adhesion,membrane,cytosolic large ribosomal subunit,dendrite,intracellular ribonucleoprotein complex,cytoplasmic ribonucleoprotein granule,extracellular exosome`>sp|P05388|RLA0_HUMAN 60S acidic ribosomal protein P0 OS=Homo sapiens OX=9606 GN=RPLP0 PE=1 SV=1O75762TRPA1 TRPA1_HUMAN@Transient receptor potential cation channel subfamily A member 1ion transport,cell surface receptor signaling pathway,response to cold,response to organic substance,response to organic cyclic compound,sensory perception of pain,response to drug,response to hydrogen peroxide,response to pain,thermoception,detection of mechanical stimulus involved in sensory perception of pain,detection of chemical stimulus involved in sensory perception of pain,release of sequestered calcium ion into cytosol,protein homotetramerization,calcium ion transmembrane transporttcalcium channel activity,channel activity,calcium-release channel activity,temperature-gated cation channel activityIplasma membrane,integral component of plasma membrane,stereocilium bundle>sp|O75762|TRPA1_HUMAN Transient receptor potential cation channel subfamily A member 1 OS=Homo sapiens OX=9606 GN=TRPA1 PE=1 SV=3P54652HSPA2 HSP72_HUMAN#Heat shock-related 70 kDa protein 2response to unfolded protein,male meiosis,spermatogenesis,spermatid development,response to heat,response to cold,protein refolding,negative regulation of inclusion body assemblyCprotein binding,ATP binding,enzyme binding,unfolded protein bindingbnucleus,cytosol,membrane,CatSper complex,extracellular exosome,blood microparticle,meiotic spindlee>sp|P54652|HSP72_HUMAN Heat shock-related 70 kDa protein 2 OS=Homo sapiens OX=9606 GN=HSPA2 PE=1 SV=1P17302GJA1 CXA1_HUMANGap junction alpha-1 protein}negative regulation of endothelial cell proliferation,chronic inflammatory response,response to ischemia,positive regulation of glomerular filtration,endothelium development,transport,apoptotic process,muscle contraction,signal transduction,positive regulation of cytosolic calcium ion concentration,cell-cell signaling,heart development,response to pH,response to glucose,vascular transport,cell communication by electrical coupling,positive regulation of cell communication by chemical coupling,ATP transport,gap junction assembly,negative regulation of cell growth,positive regulation of insulin secretion,response to lipopolysaccharide,response to retinoic acid,ion transmembrane transport,response to fluid shear stress,positive regulation of I-kappaB kinase/NF-kappaB signaling,response to peptide hormone,positive regulation of protein catabolic process,positive regulation of vasoconstriction,decidualization,neuron projection morphogenesis,protein oligomerization,regulation of calcium ion transport,negative regulation of cardiac muscle cell proliferation,negative regulation of wound healing,cellular response to mechanical stimulus,atrial cardiac muscle cell action potential,cell communication by electrical coupling involved in cardiac conduction,negative regulation of DNA biosynthetic process,regulation of bicellular tight junction assembly,positive regulation of behavioral fear responseKsignal transducer activity,gap junction channel activity,protein binding,ion transmembrane transporter activity,SH3 domain binding,PDZ domain binding,connexin binding,gap junction channel activity involved in cardiac conduction electrical coupling,gap junction channel activity involved in cell communication by electrical coupling_Golgi membrane,mitochondrion,mitochondrial outer membrane,lysosome,early endosome,multivesicular body,endoplasmic reticulum membrane,Golgi apparatus,plasma membrane,integral component of plasma membrane,fascia adherens,gap junction,connexin complex,focal adhesion,intercalated disc,Golgi-associated vesicle membrane,membrane raft,extracellular exosome\>sp|P17302|CXA1_HUMAN Gap junction alpha-1 protein OS=Homo sapiens OX=9606 GN=GJA1 PE=1 SV=2O43143DHX15 DHX15_HUMAN9Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15lmRNA splicing, via spliceosome,mRNA processing,RNA splicing,response to toxic substance,response to alkaloid}RNA binding,RNA helicase activity,double-stranded RNA binding,ATP-dependent RNA helicase activity,protein binding,ATP bindingnucleus,nucleoplasm,U12-type spliceosomal complex,nucleolus,cytoplasm,nuclear speck,U2-type post-mRNA release spliceosomal complex{>sp|O43143|DHX15_HUMAN Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 OS=Homo sapiens OX=9606 GN=DHX15 PE=1 SV=2P60660MYL6 MYL6_HUMANMyosin light polypeptide 6Mmuscle contraction,skeletal muscle tissue development,muscle filament slidingsmotor activity,calcium ion binding,protein binding,structural constituent of muscle,actin-dependent ATPase activity}cytosol,brush border,membrane,myosin complex,unconventional myosin complex,extracellular matrix,vesicle,extracellular exosomeZ>sp|P60660|MYL6_HUMAN Myosin light polypeptide 6 OS=Homo sapiens OX=9606 GN=MYL6 PE=1 SV=2Q9UKK3PARP4 PARP4_HUMAN)Protein mono-ADP-ribosyltransferase PARP4DNA repair,cellular protein modification process,protein ADP-ribosylation,transport,inflammatory response,cellular response to DNA damage stimulus,cell death,response to drugODNA binding,NAD+ ADP-ribosyltransferase activity,protein binding,enzyme bindingtnucleus,cytoplasm,cyt< osol,spindle microtubule,membrane,intracellular ribonucleoprotein complex,extracellular exosomek>sp|Q9UKK3|PARP4_HUMAN Protein mono-ADP-ribosyltransferase PARP4 OS=Homo sapiens OX=9606 GN=PARP4 PE=1 SV=3P13797PLS3 PLST_HUMAN Plastin-3jactin filament bundle assembly,actin filament network formation,actin crosslink formation,bone development*calcium ion binding,actin filament bindingFcytoplasm,cytosol,actin filament,plasma membrane,actin filament bundleI>sp|P13797|PLST_HUMAN Plastin-3 OS=Homo sapiens OX=9606 GN=PLS3 PE=1 SV=4P05106ITGB3 ITB3_HUMANIntegrin beta-32positive regulation of protein phosphorylation,positive regulation of endothelial cell proliferation,platelet degranulation,cell-substrate junction assembly,cell adhesion,cell-matrix adhesion,integrin-mediated signaling pathway,blood coagulation,positive regulation of endothelial cell migration,negative regulation of macrophage derived foam cell differentiation,negative regulation of lipid storage,smooth muscle cell migration,cell growth,cell migration,platelet activation,extracellular matrix organization,positive regulation of vascular endothelial growth factor receptor signaling pathway,cell-substrate adhesion,activation of protein kinase activity,negative regulation of lipid transport,cell adhesion mediated by integrin,heterotypic cell-cell adhesion,substrate adhesion-dependent cell spreading,tube development,apolipoprotein A-I-mediated signaling pathway,wound healing,regulation of bone resorption,negative regulation of low-density lipoprotein particle receptor biosynthetic process,viral entry into host cell,vascular endothelial growth factor receptor signaling pathway,mesodermal cell differentiation,positive regulation of peptidyl-tyrosine phosphorylation,negative regulation of lipoprotein metabolic process,leukocyte migration,negative chemotaxis,angiogenesis involved in wound healing,platelet aggregationvirus receptor activity,fibronectin binding,protease binding,protein disulfide isomerase activity,platelet-derived growth factor receptor binding,protein binding,coreceptor activity,enzyme binding,identical protein binding,vascular endothelial growth factor receptor 2 binding,cell adhesion molecule binding,extracellular matrix binding,fibroblast growth factor binding,C-X3-C chemokine binding,insulin-like growth factor I binding,neuregulin binding~nucleus,plasma membrane,integral component of plasma membrane,focal adhesion,integrin complex,cell surface,platelet alpha granule membrane,lamellipodium membrane,filopodium membrane,microvillus membrane,ruffle membrane,integrin alphav-beta3 complex,alphav-beta3 integrin-IGF-1-IGF1R complex,melanosome,receptor complex,extracellular exosome,alphav-beta3 integrin-vitronectin complexP>sp|P05106|ITB3_HUMAN Integrin beta-3 OS=Homo sapiens OX=9606 GN=ITGB3 PE=1 SV=2Q13488TCIRG1 VPP3_HUMAN'V-type proton ATPase 116 kDa subunit a3cellular defense response,vacuolar acidification,protein catabolic process in the vacuole,positive regulation of cell proliferation,insulin receptor signaling pathway,ATP synthesis coupled proton transport,ATP hydrolysis coupled proton transport,proton transport,macroautophagy,transferrin transport,ion transmembrane transport,neutrophil degranulation,vacuolar proton-transporting V-type ATPase complex assembly,phagosome acidification]transporter activity,proton-transporting ATPase activity, rotational mechanism,ATPase binding$vacuolar proton-transporting V-type ATPase, V0 domain,mitochondrion,lysosomal membrane,plasma membrane,integral component of plasma membrane,endosome membrane,apical plasma membrane,vacuolar proton-transporting V-type ATPase complex,phagocytic vesicle membrane,ficolin-1-rich granule membranei>sp|Q13488|VPP3_HUMAN V-type proton ATPase 116 kDa subunit a3 OS=Homo sapiens OX=9606 GN=TCIRG1 PE=1 SV=3Q8NBJ4GOLM1 GOLM1_HUMANGolgi membrane protein 1:nucleus organization,regulation of lipid metabolic process_extracellular space,Golgi apparatus,integral component of plasma membrane,extracellular exosomeZ>sp|Q8NBJ4|GOLM1_HUMAN Golgi membrane protein 1 OS=Homo sapiens OX=9606 GN=GOLM1 PE=1 SV=1Q6KB66KRT80 K2C80_HUMAN Keratin, type II cytoskeletal 80;cytosol,keratin filament,intermediate filament cytoskeletonb>sp|Q6KB66|K2C80_HUMAN Keratin, type II cytoskeletal 80 OS=Homo sapiens OX=9606 GN=KRT80 PE=1 SV=2P52209PGD 6PGD_HUMAN16-phosphogluconate dehydrogenase, decarboxylatingpentose-phosphate shunt,pentose-phosphate shunt, oxidative branch,pentose biosynthetic process,D-gluconate metabolic process,oxidation-reduction process9phosphogluconate dehydrogenase (decarboxylating) activity%nucleus,cytosol,extracellular exosomep>sp|P52209|6PGD_HUMAN 6-phosphogluconate dehydrogenase, decarboxylating OS=Homo sapiens OX=9606 GN=PGD PE=1 SV=3P05155SERPING1 IC1_HUMANPlasma protease C1 inhibitor negative regulation of complement activation, lectin pathway,platelet degranulation,complement activation, classical pathway,aging,blood coagulation, intrinsic pathway,blood circulation,negative regulation of endopeptidase activity,fibrinolysis,innate immune responseoextracellular region,extracellular space,platelet alpha granule lumen,extracellular exosome,blood microparticle_>sp|P05155|IC1_HUMAN Plasma protease C1 inhibitor OS=Homo sapiens OX=9606 GN=SERPING1 PE=1 SV=2P09486SPARC SPRC_HUMANossification,negative regulation of endothelial cell proliferation,platelet degranulation,receptor-mediated endocytosis,signal transduction,heart development,response to gravity,response to lead ion,positive regulation of endothelial cell migration,negative regulation of angiogenesis,regulation of cell morphogenesis,extracellular matrix organization,lung development,response to lipopolysaccharide,response to L-ascorbic acid,response to cytokine,wound healing,response to peptide hormone,pigmentation,response to ethanol,response to cadmium ion,inner ear development,response to glucocorticoid,response to cAMP,response to calcium ion,bone development,cellular response to growth factor stimulusQcalcium ion binding,protein binding,collagen binding,extracellular matrix bindingextracellular region,basement membrane,extracellular space,cytoplasm,cell surface,nuclear matrix,platelet alpha granule,platelet alpha granule membrane,platelet alpha granule lumen,endocytic vesicle lumen,mitochondrion,plasma membraneF>sp|P09486|SPRC_HUMAN SPARC OS=Homo sapiens OX=9606 GN=SPARC PE=1 SV=1P07858CTSB CATB_HUMAN Cathepsin BYtoll-like receptor signaling pathway,proteolysis,collagen catabolic process,epithelial cell differentiation,regulation of apoptotic process,neutrophil degranulation,decidualization,viral entry into host cell,regulation of catalytic activity,proteolysis involved in cellular protein catabolic process,cellular response to thyroid hormone stimuluscysteine-type endopeptidase activity,serine-type endopeptidase activity,protein binding,collagen binding,peptidase activity,cysteine-type peptidase activity,proteoglycan bindingextracellular region,extracellular space,intracellular,nucleolus,mitochondrion,lysosome,endolysosome lumen,melanosome,intracellular membrane-bounded organelle,perinuclear region of cytoplasm,extracellular exosome,ficolin-1-rich granule lumenK>sp|P07858|CATB_HUMAN Cathepsin B OS=Homo sapiens OX=9606 GN=CTSB PE=1 SV=3P28838LAP3 AMPL_HUMANCytosol aminopeptidaseJaminopeptidase activity,metalloexopeptidase activity,manganese ion bindingjnucleus,nucleoplasm,mitochondrion,trans-Golgi network,cytosol,focal adhesion,midbody,extracellular exosomeV>sp|P28838|AMPL_HUMAN Cytosol aminopeptidase OS=Homo sapiens OX=9606 GN=LAP3 PE=1 SV=3O14786NRP1 NRP1_HUMAN Neuropilin-1 angiogenesis,patterning of blood vessels,neuron migration,positive regulation of endothelial cell proliferation,sprouting angiogenesis,cell migration involved in sprouting angiogenesis,signal transduction,cell-cell signaling,axon guidance,axonal fasciculation,response to wounding,animal organ morphogenesis,positive regulation of endothelial cell migration,positive regulation of smooth muscle cell migration,dendrite development,fa< cial nerve structural organization,trigeminal nerve structural organization,vestibulocochlear nerve structural organization,nerve development,branchiomotor neuron axon guidance,gonadotrophin-releasing hormone neuronal migration to the hypothalamus,retinal ganglion cell axon guidance,cellular response to hepatocyte growth factor stimulus,endothelial cell chemotaxis,cellular response to vascular endothelial growth factor stimulus,ventral trunk neural crest cell migration,VEGF-activated neuropilin signaling pathway,negative regulation of neuron apoptotic process,platelet-derived growth factor receptor signaling pathway,vascular endothelial growth factor receptor signaling pathway,hepatocyte growth factor receptor signaling pathway,positive regulation of axon extension involved in axon guidance,negative regulation of axon extension involved in axon guidance,artery morphogenesis,axon extension involved in axon guidance,positive regulation of peptidyl-tyrosine phosphorylation,positive chemotaxis,positive regulation of cytokine activity,axonogenesis involved in innervation,regulation of vesicle-mediated transport,dichotomous subdivision of terminal units involved in salivary gland branching,angiogenesis involved in coronary vascular morphogenesis,coronary artery morphogenesis,retina vasculature morphogenesis in camera-type eye,renal artery morphogenesis,sympathetic ganglion development,trigeminal ganglion development,positive regulation of ERK1 and ERK2 cascade,semaphorin-plexin signaling pathway,commissural neuron axon guidance,regulation of retinal ganglion cell axon guidance,endothelial tip cell fate specification,sensory neuron axon guidance,sympathetic neuron projection extension,sympathetic neuron projection guidance,neural crest cell migration involved in autonomic nervous system development,toxin transport,semaphorin-plexin signaling pathway involved in neuron projection guidance,semaphorin-plexin signaling pathway involved in axon guidance,positive regulation of retinal ganglion cell axon guidance,VEGF-activated neuropilin signaling pathway involved in axon guidance,protein localization to early endosome,facioacoustic ganglion development,dorsal root ganglion morphogenesis,otic placode development,negative regulation of extrinsic apoptotic signaling pathwayvascular endothelial growth factor-activated receptor activity,protein binding,heparin binding,coreceptor activity,semaphorin receptor activity,growth factor binding,cytokine binding,vascular endothelial growth factor binding,metal ion bindingsemaphorin receptor complex,extracellular space,early endosome,cytosol,neurofilament,plasma membrane,focal adhesion,cell surface,integral component of membrane,axon,growth cone,cytoplasmic vesicle,neuronal cell body,receptor complex,sorting endosomeL>sp|O14786|NRP1_HUMAN Neuropilin-1 OS=Homo sapiens OX=9606 GN=NRP1 PE=1 SV=3Q02818NUCB1 NUCB1_HUMANNucleobindin-15response to cisplatin,regulation of protein targetingOG-protein alpha-subunit binding,DNA binding,calcium ion binding,protein binding6extracellular space,nucleus,early endosome,rough endoplasmic reticulum,endoplasmic reticulum-Golgi intermediate compartment,Golgi-associated vesicle,cis-Golgi network,trans-Golgi network,membrane,Golgi cisterna membrane,extracellular exosome,extrinsic component of Golgi membrane,lumenal side of Golgi membraneP>sp|Q02818|NUCB1_HUMAN Nucleobindin-1 OS=Homo sapiens OX=9606 GN=NUCB1 PE=1 SV=4P02675FGB FIBB_HUMANFibrinogen beta chaintoll-like receptor signaling pathway,adaptive immune response,platelet degranulation,cell-matrix adhesion,blood coagulation,extracellular matrix organization,plasminogen activation,positive regulation of heterotypic cell-cell adhesion,fibrinolysis,induction of bacterial agglutination,cellular protein complex assembly,cellular response to leptin stimulus,innate immune response,positive regulation of vasoconstriction,positive regulation of exocytosis,positive regulation of protein secretion,protein polymerization,response to calcium ion,positive regulation of ERK1 and ERK2 cascade,platelet aggregation,cellular response to interleukin-1,blood coagulation, fibrin clot formation,positive regulation of peptide hormone secretion,positive regulation of substrate adhesion-dependent cell spreading,negative regulation of extrinsic apoptotic signaling pathway via death domain receptors,negative regulation of endothelial cell apoptotic processstructural molecule activity,protein binding,protein binding, bridging,chaperone binding,receptor binding,cell adhesion molecule bindingextracellular region,fibrinogen complex,extracellular space,plasma membrane,cell cortex,external side of plasma membrane,cell surface,platelet alpha granule,platelet alpha granule lumen,extracellular exosome,blood microparticle,extracellular vesicleT>sp|P02675|FIBB_HUMAN Fibrinogen beta chain OS=Homo sapiens OX=9606 GN=FGB PE=1 SV=2O15144ARPC2 ARPC2_HUMAN+Actin-related protein 2/3 complex subunit 28movement of cell or subcellular component,positive regulation of lamellipodium assembly,Arp2/3 complex-mediated actin nucleation,Fc-gamma receptor signaling pathway involved in phagocytosis,ephrin receptor signaling pathway,membrane organization,positive regulation of substrate adhesion-dependent cell spreadingendosome,cytosol,Arp2/3 protein complex,focal adhesion,actin cytoskeleton,cell leading edge,muscle cell projection membrane,neuron projection,synapse,extracellular exosomem>sp|O15144|ARPC2_HUMAN Actin-related protein 2/3 complex subunit 2 OS=Homo sapiens OX=9606 GN=ARPC2 PE=1 SV=1P0C0L4C4A CO4A_HUMANComplement C4-Aproteolysis,inflammatory response,complement activation,complement activation, classical pathway,negative regulation of endopeptidase activity,regulation of complement activation,innate immune response,positive regulation of apoptotic cell clearancedcomplement component C1q binding,serine-type endopeptidase activity,endopeptidase inhibitor activityextracellular region,extracellular space,plasma membrane,cell junction,axon,dendrite,neuronal cell body,synapse,extracellular exosome,blood microparticleN>sp|P0C0L4|CO4A_HUMAN Complement C4-A OS=Homo sapiens OX=9606 GN=C4A PE=1 SV=2Q00839HNRNPU HNRPU_HUMAN)Heterogeneous nuclear ribonucleoprotein UmRNA splicing, via spliceosome,osteoblast differentiation,RNA processing,gene expression,negative regulation of telomere maintenance via telomerase,circadian regulation of gene expression,CRD-mediated mRNA stabilization`core promoter binding,DNA binding,RNA binding,protein binding,ATP binding,telomerase RNA bindingnucleus,nucleoplasm,cell surface,membrane,intracellular ribonucleoprotein complex,extracellular matrix,cytoplasmic ribonucleoprotein granule,CRD-mediated mRNA stability complex,catalytic step 2 spliceosome,telomerase holoenzyme complexl>sp|Q00839|HNRPU_HUMAN Heterogeneous nuclear ribonucleoprotein U OS=Homo sapiens OX=9606 GN=HNRNPU PE=1 SV=6Q9Y696CLIC4 CLIC4_HUMAN(Chloride intracellular channel protein 4 angiogenesis,endothelial cell morphogenesis,chloride transport,vacuolar acidification,fertilization,cell differentiation,keratinocyte differentiation,negative regulation of cell migration,regulation of ion transmembrane transport,establishment or maintenance of apical/basal cell polarity,multicellular organism growth,branching morphogenesis of an epithelial tube,regulation of cytoskeleton organization,retina vasculature morphogenesis in camera-type eye,cellular response to calcium ion,chloride transmembrane transportLvoltage-gated ion channel activity,chloride channel activity,protein binding7intracellular,cytoplasm,mitochondrion,centrosome,cytosol,plasma membrane,microvillus,cell-cell junction,cell surface,actin cytoskeleton,nuclear matrix,midbody,cytoplasmic vesicle membrane,chloride channel complex,apical part of cell,perinuclear region of cytoplasm,extracellular exosome,microtubule cytoskeletonj>sp|Q9Y696|CLIC4_HUMAN Chloride intracellular channel protein 4 OS=Homo sapiens OX=9606 GN=CLIC4 PE=1 SV=4Q9H4M9EHD1 EHD1_HUMANEH domain-containing protein 1intracellular protein transport,endocytosis,blood coagulatio< n,positive regulation of cholesterol storage,neuron projection development,endocytic recycling,low-density lipoprotein particle clearance,cholesterol homeostasis,protein homooligomerization,cilium morphogenesis,protein localization to cilium,positive regulation of myoblast fusion,cellular response to nerve growth factor stimulus,positive regulation of endocytic recycling_calcium ion binding,protein binding,ATP binding,GTP binding,Rab GTPase binding,cadherin bindinglipid particle,plasma membrane,endosome membrane,membrane,ciliary pocket membrane,platelet dense tubular network membrane,early endosome membrane,recycling endosome membrane,extracellular exosome^>sp|Q9H4M9|EHD1_HUMAN EH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=EHD1 PE=1 SV=2O95373IPO7 IPO7_HUMAN Importin-7uprotein import into nucleus,signal transduction,viral process,innate immune response,regulation of catalytic activityntransporter activity,protein binding,Ran GTPase binding,GTPase regulator activity,histone binding,SMAD binding)nuclear pore,nucleoplasm,cytosol,membraneJ>sp|O95373|IPO7_HUMAN Importin-7 OS=Homo sapiens OX=9606 GN=IPO7 PE=1 SV=1P09603CSF1 CSF1_HUMAN&Macrophage colony-stimulating factor 1positive regulation of cell-matrix adhesion,osteoclast proliferation,developmental process involved in reproduction,inflammatory response,transmembrane receptor protein tyrosine kinase signaling pathway,cell proliferation,positive regulation of cell proliferation,positive regulation of gene expression,regulation of macrophage derived foam cell differentiation,positive regulation of macrophage derived foam cell differentiation,positive regulation of macrophage chemotaxis,hemopoiesis,cell differentiation,macrophage differentiation,regulation of ossification,osteoclast differentiation,positive regulation of cell migration,positive regulation of cellular protein metabolic process,positive regulation of mononuclear cell proliferation,macrophage colony-stimulating factor signaling pathway,positive regulation of multicellular organism growth,monocyte activation,positive regulation of odontogenesis of dentin-containing tooth,innate immune response,positive regulation of macrophage differentiation,positive regulation of monocyte differentiation,positive regulation of osteoclast differentiation,positive regulation of protein kinase activity,positive regulation of Ras protein signal transduction,homeostasis of number of cells within a tissue,branching involved in mammary gland duct morphogenesis,mammary gland fat development,mammary duct terminal end bud growth,positive regulation of macrophage colony-stimulating factor signaling pathway,positive regulation of microglial cell migrationcytokine activity,macrophage colony-stimulating factor receptor binding,protein binding,growth factor activity,protein homodimerization activityextracellular space,plasma membrane,membrane,integral component of membrane,perinuclear region of cytoplasm,extracellular exosome,CSF1-CSF1R complexf>sp|P09603|CSF1_HUMAN Macrophage colony-stimulating factor 1 OS=Homo sapiens OX=9606 GN=CSF1 PE=1 SV=2P35237SERPINB6 SPB6_HUMAN Serpin B6sensory perception of sound,negative regulation of endopeptidase activity,neutrophil degranulation,cellular response to osmotic stress=protease binding,serine-type endopeptidase inhibitor activityextracellular space,cytoplasm,cytosol,plasma membrane,secretory granule membrane,protein complex,extracellular exosome,tertiary granule membrane,ficolin-1-rich granule membrane,nucleusM>sp|P35237|SPB6_HUMAN Serpin B6 OS=Homo sapiens OX=9606 GN=SERPINB6 PE=1 SV=3Q15758SLC1A5 AAAT_HUMAN#Neutral amino acid transporter B(0)amino acid transmembrane transport,extracellular amino acid transport,amino acid transport,glutamine transport,neutral amino acid transport,L-serine transport,viral entry into host cell virus receptor activity,receptor activity,protein binding,amino acid transmembrane transporter activity,neutral amino acid transmembrane transporter activity,L-glutamine transmembrane transporter activity,L-serine transmembrane transporter activity,symporter activity_plasma membrane,integral component of plasma membrane,membrane,melanosome,extracellular exosomee>sp|Q15758|AAAT_HUMAN Neutral amino acid transporter B(0) OS=Homo sapiens OX=9606 GN=SLC1A5 PE=1 SV=2P42025ACTR1B ACTY_HUMANBeta-centractinjantigen processing and presentation of exogenous peptide antigen via MHC class II,neutrophil degranulationprotein binding,ATP bindingextracellular region,cytoplasm,centrosome,cytosol,dynactin complex,microtubule cytoskeleton,membrane,secretory granule lumen,extracellular exosome,ficolin-1-rich granule lumenQ>sp|P42025|ACTY_HUMAN Beta-centractin OS=Homo sapiens OX=9606 GN=ACTR1B PE=1 SV=1P28482MAPK1 MK01_HUMAN"Mitogen-activated protein kinase 1 MAPK cascade,activation of MAPK activity,MAPK import into nucleus,transcription, DNA-templated,protein phosphorylation,apoptotic process,chemotaxis,response to stress,cellular response to DNA damage stimulus,cell cycle,signal transduction,chemical synaptic transmission,axon guidance,learning or memory,positive regulation of cell proliferation,fibroblast growth factor receptor signaling pathway,response to toxic substance,regulation of gene expression,positive regulation of peptidyl-threonine phosphorylation,regulation of phosphatidylinositol 3-kinase signaling,viral process,peptidyl-serine phosphorylation,peptidyl-threonine phosphorylation,sensory perception of pain,cytosine metabolic process,platelet activation,regulation of ossification,positive regulation of cell migration,thyroid gland development,regulation of protein stability,lipopolysaccharide-mediated signaling pathway,positive regulation of telomere maintenance via telomerase,regulation of stress-activated MAPK cascade,mammary gland epithelial cell proliferation,response to nicotine,Fc-epsilon receptor signaling pathway,Fc-gamma receptor signaling pathway involved in phagocytosis,ERBB signaling pathway,outer ear morphogenesis,neutrophil degranulation,response to exogenous dsRNA,response to estrogen,negative regulation of cell differentiation,positive regulation of translation,positive regulation of transcription, DNA-templated,thymus development,T cell receptor signaling pathway,B cell receptor signaling pathway,regulation of sequence-specific DNA binding transcription factor activity,regulation of cytoskeleton organization,positive regulation of telomerase activity,Bergmann glial cell differentiation,long-term synaptic potentiation,face development,JAK-STAT cascade involved in growth hormone signaling pathway,lung morphogenesis,trachea formation,labyrinthine layer blood vessel development,cardiac neural crest cell development involved in heart development,ERK1 and ERK2 cascade,response to epidermal growth factor,cellular response to organic substance,caveolin-mediated endocytosis,regulation of Golgi inheritance,cellular response to granulocyte macrophage colony-stimulating factor stimulus,regulation of cellular response to heat,positive regulation of telomere capping,regulation of early endosome to late endosome transportHphosphotyrosine binding,DNA binding,protein serine/threonine kinase activity,MAP kinase activity,protein binding,ATP binding,transcription factor binding,RNA polymerase II carboxy-terminal domain kinase activity,kinase activity,phosphatase binding,mitogen-activated protein kinase kinase kinase binding,identical protein bindingRextracellular region,nucleus,nucleoplasm,cytoplasm,mitochondrion,early endosome,late endosome,Golgi apparatus,microtubule organizing center,cytosol,cytoskeleton,caveola,focal adhesion,axon,pseudopodium,dendrite cytoplasm,azurophil granule lumen,perikaryon,protein complex,extracellular exosome,mitotic spindle,ficolin-1-rich granule lumenc>sp|P28482|MK01_HUMAN Mitogen-activated protein kinase 1 OS=Homo sapiens OX=9606 GN=MAPK1 PE=1 SV=3O94973AP2A2 AP2A2_HUMANAP-2 complex subunit alpha-2intracellular protein transport,receptor-mediated endocytosis,microtubule-based movement,antigen processing and presentation of exogenous peptide antigen via MHC < class II,neutrophil degranulation,ephrin receptor signaling pathway,regulation of defense response to virus by virus,Wnt signaling pathway, planar cell polarity pathway,membrane organization,clathrin-dependent endocytosis~molecular_function,protein binding,lipid binding,protein transporter activity,protein kinase binding,clathrin adaptor activitycytosol,plasma membrane,AP-2 adaptor complex,endocytic vesicle membrane,secretory granule membrane,clathrin-coated endocytic vesicle membrane,cytoplasmic vesicle,endolysosome membrane,ficolin-1-rich granule membrane^>sp|O94973|AP2A2_HUMAN AP-2 complex subunit alpha-2 OS=Homo sapiens OX=9606 GN=AP2A2 PE=1 SV=2P61247RPS3A RS3A_HUMAN40S ribosomal protein S3anuclear-transcribed mRNA catabolic process, nonsense-mediated decay,rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,viral transcription,cell differentiation,negative regulation of apoptotic processnucleus,nucleoplasm,nucleolus,cytoplasm,endoplasmic reticulum,cytosol,focal adhesion,cytosolic small ribosomal subunit,intracellular ribonucleoprotein complex,extracellular matrix,extracellular exosomeZ>sp|P61247|RS3A_HUMAN 40S ribosomal protein S3a OS=Homo sapiens OX=9606 GN=RPS3A PE=1 SV=2P55884EIF3B EIF3B_HUMAN4Eukaryotic translation initiation factor 3 subunit Btranslational initiation,regulation of translational initiation,IRES-dependent viral translational initiation,viral translational termination-reinitiationnucleotide binding,RNA binding,translation initiation factor activity,protein binding,translation initiation factor binding,protein complex scaffoldv>sp|P55884|EIF3B_HUMAN Eukaryotic translation initiation factor 3 subunit B OS=Homo sapiens OX=9606 GN=EIF3B PE=1 SV=3P62249RPS16 RS16_HUMAN40S ribosomal protein S16Dnuclear-transcribed mRNA catabolic process, nonsense-mediated decay,maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA),rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,viral transcription,ribosomal small subunit biogenesisnucleoplasm,cytosol,focal adhesion,small ribosomal subunit,membrane,cytosolic small ribosomal subunit,extracellular matrix,extracellular exosomeZ>sp|P62249|RS16_HUMAN 40S ribosomal protein S16 OS=Homo sapiens OX=9606 GN=RPS16 PE=1 SV=2Q9NQC3RTN4 RTN4_HUMAN Reticulon-4apoptotic process,axonal fasciculation,cerebral cortex radial glia guided migration,negative regulation of cell growth,negative regulation of axon extension,regulation of apoptotic process,negative regulation of axonogenesis,nuclear pore complex assembly,cardiac epithelial to mesenchymal transition,endoplasmic reticulum tubular network organization,endoplasmic reticulum tubular network assembly,regulation of branching morphogenesis of a nerve,RNA binding,protein binding,cadherin bindingintracellular,nuclear envelope,endoplasmic reticulum,endoplasmic reticulum membrane,plasma membrane,postsynaptic density,integral component of endoplasmic reticulum membrane,cell projection,extracellular exosomeK>sp|Q9NQC3|RTN4_HUMAN Reticulon-4 OS=Homo sapiens OX=9606 GN=RTN4 PE=1 SV=2P46781RPS9 RS9_HUMAN40S ribosomal protein S9 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,positive regulation of cell proliferation,viral transcription,positive regulation of translational fidelityjRNA binding,structural constituent of ribosome,protein binding,rRNA binding,translation regulator activitynucleus,nucleoplasm,nucleolus,cytoplasm,cytosol,ribosome,focal adhesion,membrane,cytosolic small ribosomal subunit,intracellular ribonucleoprotein complex,extracellular exosomeW>sp|P46781|RS9_HUMAN 40S ribosomal protein S9 OS=Homo sapiens OX=9606 GN=RPS9 PE=1 SV=3P13726F3TF_HUMAN Tissue factorgpositive regulation of endothelial cell proliferation,activation of plasma proteins involved in acute inflammatory response,activation of blood coagulation via clotting cascade,activation of cysteine-type endopeptidase activity involved in apoptotic process,blood coagulation,blood coagulation, extrinsic pathway,positive regulation of platelet-derived growth factor receptor signaling pathway,protein processing,cytokine-mediated signaling pathway,positive regulation of cell migration,positive regulation of angiogenesis,positive regulation of positive chemotaxis,positive regulation of protein kinase B signalingsprotease binding,cytokine receptor activity,protein binding,phospholipid binding,serine-type endopeptidase activityextracellular space,plasma membrane,cell surface,integral component of membrane,extracellular matrix,intrinsic component of external side of plasma membrane,extracellular exosome,serine-type peptidase complexI>sp|P13726|TF_HUMAN Tissue factor OS=Homo sapiens OX=9606 GN=F3 PE=1 SV=1P39023RPL3 RL3_HUMAN60S ribosomal protein L3jnucleus,nucleolus,cytoplasm,cytosol,focal adhesion,cytosolic large ribosomal subunit,extracellular exosomeW>sp|P39023|RL3_HUMAN 60S ribosomal protein L3 OS=Homo sapiens OX=9606 GN=RPL3 PE=1 SV=2Q99873PRMT1 ANM1_HUMAN&Protein arginine N-methyltransferase 1 protein methylation,DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest,cell surface receptor signaling pathway,histone methylation,peptidyl-arginine methylation,peptidyl-arginine methylation, to asymmetrical-dimethyl arginine,neuron projection development,histone H4-R3 methylation,positive regulation of erythrocyte differentiation,negative regulation of megakaryocyte differentiation,positive regulation of hemoglobin biosynthetic process,positive regulation of p38MAPK cascadeRNA binding,protein binding,methyltransferase activity,N-methyltransferase activity,protein methyltransferase activity,methyl-CpG binding,protein-arginine N-methyltransferase activity,enzyme binding,protein-arginine omega-N asymmetric methyltransferase activity,histone methyltransferase activity,identical protein binding,histone methyltransferase activity (H4-R3 specific),mitogen-activated protein kinase p38 binding1nucleus,nucleoplasm,cytoplasm,cytosol,methylosomeg>sp|Q99873|ANM1_HUMAN Protein arginine N-methyltransferase 1 OS=Homo sapiens OX=9606 GN=PRMT1 PE=1 SV=3P02462COL4A1 CO4A1_HUMANCollagen alpha-1(IV) chainpatterning of blood vessels,brain development,neuromuscular junction development,extracellular matrix organization,collagen catabolic process,epithelial cell differentiation,collagen-activated tyrosine kinase receptor signaling pathway,blood vessel morphogenesis,retinal blood vessel morphogenesis,renal tubule morphogenesis,cellular response to amino acid stimulus,basement membrane organizationextracellular matrix structural constituent,protein binding,extracellular matrix constituent conferring elasticity,platelet-derived growth factor bindingextracellular region,collagen type IV trimer,basement membrane,extracellular space,endoplasmic reticulum lumen,extracellular matrix]>sp|P02462|CO4A1_HUMAN Collagen alpha-1(IV) chain OS=Homo sapiens OX=9606 GN=COL4A1 PE=1 SV=4Q12841FSTL1 FSTL1_HUMANFollistatin-related protein 1,BMP signaling pathway,response to starvation3calcium ion binding,protein binding,heparin binding_>sp|Q12841|FSTL1_HUMAN Follistatin-related protein 1 OS=Homo sapiens OX=9606 GN=FSTL1 PE=1 SV=1P38606ATP6V1A VATA_HUMAN(V-type proton ATPase catalytic subunit Atransport,insulin receptor signaling pathway,ATP hydrolysis coupled proton transport,regulation of macroautophagy,transferrin transport,ion transmembrane transport,ATP metabolic process,phagosome acidificationEATP binding,proton-transporting ATPase activity, rotational mechanismmitochondrion,lysosomal membrane,cytosol,plasma membrane,integral component of plasma membrane,microvillus,apical plasma membrane,proton-transporting two-sector ATPase complex,proton-transporting V-type ATPase, V1 domain,myelin sheath,extracellular exosomek>sp|P38606|VATA_HUMA< N V-type proton ATPase catalytic subunit A OS=Homo sapiens OX=9606 GN=ATP6V1A PE=1 SV=2Q92859NEO1 NEO1_HUMANNeogenin]cell adhesion,axon guidance,positive regulation of BMP signaling pathway,iron ion homeostasis5receptor activity,protein binding,co-receptor bindingqnucleoplasm,Golgi apparatus,plasma membrane,integral component of plasma membrane,plasma membrane protein complexH>sp|Q92859|NEO1_HUMAN Neogenin OS=Homo sapiens OX=9606 GN=NEO1 PE=1 SV=2Q13418ILK ILK_HUMANIntegrin-linked protein kinaseGMAPK cascade,branching involved in ureteric bud morphogenesis,positive regulation of cell-matrix adhesion,outflow tract morphogenesis,protein phosphorylation,negative regulation of protein kinase activity,cell cycle arrest,cell-matrix adhesion,integrin-mediated signaling pathway,multicellular organism development,cell aging,cell proliferation,positive regulation of cell proliferation,negative regulation of cardiac muscle cell apoptotic process,fibroblast migration,negative regulation of smooth muscle cell migration,peptidyl-serine phosphorylation,nerve development,myelination in peripheral nervous system,positive regulation of cell migration,positive regulation of BMP signaling pathway,myelin assembly,regulation of actin cytoskeleton organization,cell junction assembly,substrate adhesion-dependent cell spreading,positive regulation of phosphorylation,positive regulation of MAP kinase activity,protein kinase B signaling,negative regulation of neuron apoptotic process,establishment or maintenance of epithelial cell apical/basal polarity,positive regulation of myoblast differentiation,positive regulation of osteoblast differentiation,positive regulation of axon extension,positive regulation of transcription, DNA-templated,negative regulation of smooth muscle cell proliferation,neuron projection morphogenesis,positive regulation of dendrite morphogenesis,protein heterooligomerization,positive regulation of protein kinase B signaling,platelet aggregation,positive regulation of canonical Wnt signaling pathway,fibril organization,negative regulation of neural precursor cell proliferationprotein serine/threonine kinase activity,signal transducer activity,integrin binding,protein binding,ATP binding,SH3 domain binding,protein kinase bindingnucleoplasm,cytoplasm,cytosol,plasma membrane,cell-cell junction,focal adhesion,membrane,sarcomere,lamellipodium,cell junction,neuronal cell body,costamere,terminal bouton,dendritic shaft,protein complex,stress fiber\>sp|Q13418|ILK_HUMAN Integrin-linked protein kinase OS=Homo sapiens OX=9606 GN=ILK PE=1 SV=2P29317EPHA2 EPHA2_HUMANEphrin type-A receptor 2qskeletal system development,vasculogenesis,osteoblast differentiation,blood vessel endothelial cell proliferation involved in sprouting angiogenesis,inflammatory response,cell adhesion,multicellular organism development,intrinsic apoptotic signaling pathway in response to DNA damage,regulation of lamellipodium assembly,notochord formation,viral process,cell migration,negative regulation of angiogenesis,peptidyl-tyrosine phosphorylation,neural tube development,neuron differentiation,keratinocyte differentiation,osteoclast differentiation,negative regulation of chemokine production,mammary gland epithelial cell proliferation,regulation of cell adhesion mediated by integrin,post-anal tail morphogenesis,protein kinase B signaling,regulation of blood vessel endothelial cell migration,regulation of angiogenesis,cAMP metabolic process,bone remodeling,ephrin receptor signaling pathway,axial mesoderm formation,cell motility,defense response to Gram-positive bacterium,negative regulation of protein kinase B signaling,notochord cell development,cell chemotaxis,branching involved in mammary gland duct morphogenesis,lens fiber cell morphogenesis,regulation of ERK1 and ERK2 cascade,response to growth factor,positive regulation of establishment of protein localization to plasma membrane,activation of GTPase activity,negative regulation of lymphangiogenesis,pericyte cell differentiation}transmembrane receptor protein tyrosine kinase activity,ephrin receptor activity,protein binding,ATP binding,cadherin bindingintracellular,plasma membrane,integral component of plasma membrane,focal adhesion,cell surface,lamellipodium,leading edge membrane,lamellipodium membrane,ruffle membraneZ>sp|P29317|EPHA2_HUMAN Ephrin type-A receptor 2 OS=Homo sapiens OX=9606 GN=EPHA2 PE=1 SV=2Q15019SEPTIN2 SEPT2_HUMANSeptin-2mitotic nuclear division,smoothened signaling pathway,spermatogenesis,neuron projection development,cell division,cilium morphogenesis,protein binding,GTP binding,cadherin binding)exocyst,condensed chromosome kinetochore,nucleus,nucleolus,cytoplasm,spindle,cytosol,axoneme,actin cytoskeleton,midbody,septin complex,cleavage furrow,photoreceptor connecting cilium,perinuclear region of cytoplasm,ciliary membrane,extracellular exosome,sperm annulus,Requires Ontology,cell cortexL>sp|Q15019|SEPT2_HUMAN Septin-2 OS=Homo sapiens OX=9606 GN=SEPTIN2 PE=1 SV=1P00387CYB5R3 NB5R3_HUMANNADH-cytochrome b5 reductase 3cholesterol biosynthetic process,xenobiotic metabolic process,blood circulation,L-ascorbic acid metabolic process,neutrophil degranulation,oxidation-reduction processcytochrome-b5 reductase activity, acting on NAD(P)H,AMP binding,oxidoreductase activity,ADP binding,flavin adenine dinucleotide binding,NAD bindingextracellular region,cytoplasm,mitochondrion,mitochondrial outer membrane,mitochondrial inner membrane,endoplasmic reticulum,endoplasmic reticulum membrane,lipid particle,hemoglobin complex,membrane,azurophil granule lumen,extracellular exosomea>sp|P00387|NB5R3_HUMAN NADH-cytochrome b5 reductase 3 OS=Homo sapiens OX=9606 GN=CYB5R3 PE=1 SV=3O00299CLIC1 CLIC1_HUMAN(Chloride intracellular channel protein 1chloride transport,signal transduction,regulation of ion transmembrane transport,positive regulation of osteoblast differentiation,regulation of cell cycle,regulation of mitochondrial membrane potential,platelet aggregation,chloride transmembrane transport]voltage-gated ion channel activity,chloride channel activity,protein binding,cadherin bindingextracellular space,nucleus,nuclear envelope,cytoplasm,mitochondrion,plasma membrane,brush border,membrane,nuclear membrane,vesicle,chloride channel complex,perinuclear region of cytoplasm,extracellular exosome,blood microparticlej>sp|O00299|CLIC1_HUMAN Chloride intracellular channel protein 1 OS=Homo sapiens OX=9606 GN=CLIC1 PE=1 SV=4P45880VDAC2 VDAC2_HUMAN3Voltage-dependent anion-selective channel protein 2anion transport,negative regulation of protein polymerization,transmembrane transport,regulation of anion transmembrane transport,negative regulation of intrinsic apoptotic signaling pathwayVnucleotide binding,protein binding,voltage-gated anion channel activity,porin activitynucleus,mitochondrion,mitochondrial outer membrane,mitochondrial inner membrane,synaptic vesicle,mitochondrial nucleoid,myelin sheath,pore complex,extracellular exosomeu>sp|P45880|VDAC2_HUMAN Voltage-dependent anion-selective channel protein 2 OS=Homo sapiens OX=9606 GN=VDAC2 PE=1 SV=2P16152CBR1 CBR1_HUMANCarbonyl reductase [NADPH] 1drug metabolic process,cyclooxygenase pathway,epithelial cell differentiation,vitamin K metabolic process,oxidation-reduction processcarbonyl reductase (NADPH) activity,oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor,15-hydroxyprostaglandin dehydrogenase (NADP+) activity,prostaglandin-E2 9-reductase activity3cytosol,extracellular exosome,extracellular vesicle\>sp|P16152|CBR1_HUMAN Carbonyl reductase [NADPH] 1 OS=Homo sapiens OX=9606 GN=CBR1 PE=1 SV=3O00571DDX3X DDX3X_HUMAN ATP-dependent RNA helicase DDX3Xtranscription, DNA-templated,chromosome segregation,extrinsic apoptotic signaling pathway via death domain receptors,response to virus,RNA secondary structure unwinding,positive regulation of gene expression,Wnt signaling pathway,negative regulation of translation,positive regulation of cell growth,negative regulation of cell growth,negative regulation of protein co< mplex assembly,DNA duplex unwinding,positive regulation of interferon-beta production,stress granule assembly,intracellular signal transduction,mature ribosome assembly,positive regulation of apoptotic process,negative regulation of apoptotic process,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process,positive regulation of cysteine-type endopeptidase activity involved in apoptotic process,neutrophil degranulation,positive regulation of viral genome replication,innate immune response,positive regulation of translation,positive regulation of transcription from RNA polymerase II promoter,positive regulation of translational initiation,cellular response to arsenic-containing substance,cellular response to osmotic stress,positive regulation of chemokine (C-C motif) ligand 5 production,intrinsic apoptotic signaling pathway,positive regulation of G1/S transition of mitotic cell cycle,protein localization to cytoplasmic stress granule,negative regulation of intrinsic apoptotic signaling pathwayDNA binding,RNA binding,GTPase activity,ATP-dependent DNA helicase activity,ATP-dependent RNA helicase activity,protein binding,ATP binding,transcription factor binding,poly(A) binding,eukaryotic initiation factor 4E binding,ATPase activity,nucleoside-triphosphatase activity,translation initiation factor binding,RNA stem-loop binding,ribosomal small subunit binding,CTPase activity,cadherin binding,mRNA 5'-UTR bindingextracellular region,nucleus,cytoplasm,mitochondrial outer membrane,cytosol,cytoplasmic stress granule,nuclear speck,secretory granule lumen,extracellular exosome,ficolin-1-rich granule lumen,eukaryotic translation initiation factor 3 complex,cytosolic small ribosomal subunitb>sp|O00571|DDX3X_HUMAN ATP-dependent RNA helicase DDX3X OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=3P19338NCL NUCL_HUMAN Nucleolinangiogenesis,positive regulation of transcription from RNA polymerase II promoter,cellular response to epidermal growth factor stimulus,positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoterynucleotide binding,RNA binding,protein binding,protein C-terminus binding,telomeric DNA binding,identical protein bindingnucleus,nucleoplasm,nucleolus,cell cortex,membrane,intracellular ribonucleoprotein complex,cytoplasmic ribonucleoprotein granule,extracellular exosomeH>sp|P19338|NUCL_HUMAN Nucleolin OS=Homo sapiens OX=9606 GN=NCL PE=1 SV=3Q9NVA2SEPTIN11 SEP11_HUMAN Septin-116cell cycle,protein heterooligomerization,cell divisionOstress fiber,cytoplasm,cell junction,axon,dendritic spine,extracellular exosomeN>sp|Q9NVA2|SEP11_HUMAN Septin-11 OS=Homo sapiens OX=9606 GN=SEPTIN11 PE=1 SV=3Q7Z6Z7HUWE1 HUWE1_HUMAN!E3 ubiquitin-protein ligase HUWE1protein polyubiquitination,base-excision repair,protein monoubiquitination,histone ubiquitination,cell differentiation,neutrophil degranulation,positive regulation of protein targeting to mitochondrionNDNA binding,RNA binding,ubiquitin-protein transferase activity,protein bindingextracellular region,nucleus,nucleoplasm,cytoplasm,cytosol,membrane,secretory granule lumen,extracellular exosome,ficolin-1-rich granule lumenc>sp|Q7Z6Z7|HUWE1_HUMAN E3 ubiquitin-protein ligase HUWE1 OS=Homo sapiens OX=9606 GN=HUWE1 PE=1 SV=3Q9Y3I0RTCB RTCB_HUMAN RNA-splicing ligase RtcB homologlin utero embryonic development,placenta development,tRNA splicing, via endonucleolytic cleavage and ligationdRNA binding,RNA ligase (ATP) activity,protein binding,ATP binding,vinculin binding,metal ion bindingnucleus,nuclear envelope,nucleoplasm,cytoplasm,endoplasmic reticulum membrane,cytosol,intracellular membrane-bounded organelle,tRNA-splicing ligase complex`>sp|Q9Y3I0|RTCB_HUMAN RNA-splicing ligase RtcB homolog OS=Homo sapiens OX=9606 GN=RTCB PE=1 SV=1P62191PSMC1 PRS4_HUMAN#26S proteasome regulatory subunit 4MAPK cascade,protein polyubiquitination,stimulatory C-type lectin receptor signaling pathway,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent,protein folding,regulation of cellular amino acid metabolic process,negative regulation of G2/M transition of mitotic cell cycle,protein deubiquitination,ER-associated ubiquitin-dependent protein catabolic process,anaphase-promoting complex-dependent catabolic process,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process,tumor necrosis factor-mediated signaling pathway,NIK/NF-kappaB signaling,Fc-epsilon receptor signaling pathway,proteasome-mediated ubiquitin-dependent protein catabolic process,regulation of mRNA stability,positive regulation of RNA polymerase II transcriptional preinitiation complex assembly,T cell receptor signaling pathway,negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition,transmembrane transport,Wnt signaling pathway, planar cell polarity pathway,regulation of transcription from RNA polymerase II promoter in response to hypoxia,negative regulation of canonical Wnt signaling pathway,positive regulation of canonical Wnt signaling pathway,negative regulation of neuron death,positive regulation of proteasomal protein catabolic processwRNA binding,protein binding,ATP binding,ATPase activity,TBP-class protein binding,proteasome-activating ATPase activityproteasome complex,nucleus,nucleoplasm,cytosol,proteasome regulatory particle, base subcomplex,membrane,proteasome accessory complex,nuclear proteasome complex,cytosolic proteasome complexd>sp|P62191|PRS4_HUMAN 26S proteasome regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PSMC1 PE=1 SV=1O15439ABCC4 MRP4_HUMAN*ATP-binding cassette sub-family C member 4-platelet degranulation,biological_process,response to organonitrogen compound,response to organic cyclic compound,prostaglandin secretion,response to drug,positive regulation of smooth muscle cell proliferation,transmembrane transport,oxidation-reduction process,cilium morphogenesis,Requires OntologyATP binding,ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism,15-hydroxyprostaglandin dehydrogenase (NAD+) activity,ATPase activity, coupled to transmembrane movement of substances,ATPase-coupled anion transmembrane transporter activityzplasma membrane,integral component of plasma membrane,membrane,basolateral plasma membrane,platelet dense granule membranek>sp|O15439|MRP4_HUMAN ATP-binding cassette sub-family C member 4 OS=Homo sapiens OX=9606 GN=ABCC4 PE=1 SV=3P06576ATP5F1B ATPB_HUMAN(ATP synthase subunit beta, mitochondrialiangiogenesis,osteoblast differentiation,generation of precursor metabolites and energy,lipid metabolic process,ATP biosynthetic process,negative regulation of cell adhesion involved in substrate-bound cell migration,mitochondrion organization,proton transport,mitochondrial ATP synthesis coupled proton transport,regulation of intracellular pH,Requires Ontologytransporter activity,protein binding,ATP binding,transmembrane transporter activity,MHC class I protein binding,proton-transporting ATP synthase activity, rotational mechanism,proton-transporting ATPase activity, rotational mechanism,ATPase activity-nucleus,mitochondrion,mitochondrial proton-transporting ATP synthase complex,mitochondrial proton-transporting ATP synthase, catalytic core,mitochondrial matrix,plasma membrane,cell surface,membrane,extracellular matrix,mitochondrial membrane,mitochondrial nucleoid,myelin sheath,extracellular exosomek>sp|P06576|ATPB_HUMAN ATP synthase subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1B PE=1 SV=3O94979SEC31A SC31A_HUMAN Protein transport protein Sec31A'antigen processing and presentation of peptide antigen via MHC class I,ER to Golgi vesicle-mediated transport,protein transport,antigen processing and presentation of exogenous peptide antigen via MHC class II,IRE1-mediated unfolded protein response,COPII vesicle coating,response to calcium ion#Golgi membrane,cytoplasm,endoplasmic reticulum,endoplasmic reticulum membran< e,cytosol,ER to Golgi transport vesicle membrane,vesicle coat,COPII vesicle coat,ER to Golgi transport vesicle,intracellular membrane-bounded organelle,perinuclear region of cytoplasm,endoplasmic reticulum exit sitec>sp|O94979|SC31A_HUMAN Protein transport protein Sec31A OS=Homo sapiens OX=9606 GN=SEC31A PE=1 SV=3P17980PSMC3 PRS6A_HUMAN$26S proteasome regulatory subunit 6AMAPK cascade,protein polyubiquitination,blastocyst development,stimulatory C-type lectin receptor signaling pathway,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent,regulation of cellular amino acid metabolic process,negative regulation of G2/M transition of mitotic cell cycle,viral process,protein deubiquitination,ER-associated ubiquitin-dependent protein catabolic process,anaphase-promoting complex-dependent catabolic process,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process,tumor necrosis factor-mediated signaling pathway,NIK/NF-kappaB signaling,Fc-epsilon receptor signaling pathway,proteasome-mediated ubiquitin-dependent protein catabolic process,neutrophil degranulation,regulation of mRNA stability,positive regulation of RNA polymerase II transcriptional preinitiation complex assembly,T cell receptor signaling pathway,negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition,transmembrane transport,Wnt signaling pathway, planar cell polarity pathway,regulation of transcription from RNA polymerase II promoter in response to hypoxia,negative regulation of canonical Wnt signaling pathway,positive regulation of canonical Wnt signaling pathway,positive regulation of proteasomal protein catabolic process,negative regulation of nucleic acid-templated transcriptiontranscription coactivator activity,transcription corepressor activity,protein binding,ATP binding,ATPase activity,TBP-class protein binding,proteasome-activating ATPase activity,identical protein binding'proteasome complex,cytoplasmic mRNA processing body,extracellular region,nucleus,nucleoplasm,cytosol,proteasome regulatory particle, base subcomplex,membrane,proteasome accessory complex,nuclear proteasome complex,cytosolic proteasome complex,secretory granule lumen,ficolin-1-rich granule lumenf>sp|P17980|PRS6A_HUMAN 26S proteasome regulatory subunit 6A OS=Homo sapiens OX=9606 GN=PSMC3 PE=1 SV=3Q92900UPF1 RENT1_HUMAN#Regulator of nonsense transcripts 1\nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay,telomere maintenance,nuclear-transcribed mRNA catabolic process,DNA replication,DNA repair,mRNA export from nucleus,regulation of translational termination,dosage compensation by inactivation of X chromosome,telomere maintenance via semi-conservative replication,positive regulation of mRNA catabolic process,3'-UTR-mediated mRNA destabilization,histone mRNA catabolic process,cellular response to lipopolysaccharide,cellular response to interleukin-1chromatin binding,RNA binding,ATP-dependent RNA helicase activity,helicase activity,protein binding,ATP binding,zinc ion binding,telomeric DNA bindingnuclear chromosome, telomeric region,chromatin,cytoplasmic mRNA processing body,nucleus,nucleoplasm,cytoplasm,cytosol,exon-exon junction complex,supraspliceosomal complexd>sp|Q92900|RENT1_HUMAN Regulator of nonsense transcripts 1 OS=Homo sapiens OX=9606 GN=UPF1 PE=1 SV=2Q13561DCTN2 DCTN2_HUMANDynactin subunit 2:G2/M transition of mitotic cell cycle,ER to Golgi vesicle-mediated transport,mitotic spindle organization,mitotic nuclear division,cell proliferation,antigen processing and presentation of exogenous peptide antigen via MHC class II,melanosome transport,protein localization to centrosome,ciliary basal body dockingImotor activity,protein binding,spectrin binding,identical protein bindingkinetochore,cytoplasm,centrosome,cytosol,dynactin complex,microtubule,membrane,dynein complex,growth cone,vesicle,extracellular exosomeT>sp|Q13561|DCTN2_HUMAN Dynactin subunit 2 OS=Homo sapiens OX=9606 GN=DCTN2 PE=1 SV=4P62333PSMC6 PRS10_HUMAN%26S proteasome regulatory subunit 10BMAPK cascade,protein polyubiquitination,stimulatory C-type lectin receptor signaling pathway,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent,ubiquitin-dependent protein catabolic process,regulation of cellular amino acid metabolic process,negative regulation of G2/M transition of mitotic cell cycle,protein deubiquitination,ER-associated ubiquitin-dependent protein catabolic process,anaphase-promoting complex-dependent catabolic process,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process,tumor necrosis factor-mediated signaling pathway,NIK/NF-kappaB signaling,Fc-epsilon receptor signaling pathway,proteasome-mediated ubiquitin-dependent protein catabolic process,regulation of mRNA stability,positive regulation of RNA polymerase II transcriptional preinitiation complex assembly,T cell receptor signaling pathway,negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition,transmembrane transport,Wnt signaling pathway, planar cell polarity pathway,regulation of transcription from RNA polymerase II promoter in response to hypoxia,negative regulation of canonical Wnt signaling pathway,positive regulation of canonical Wnt signaling pathway,positive regulation of proteasomal protein catabolic processprotein binding,ATP binding,ATPase activity,TBP-class protein binding,protein binding, bridging,proteasome-activating ATPase activity,identical protein bindingproteasome complex,nucleus,nucleoplasm,cytosol,proteasome regulatory particle, base subcomplex,membrane,proteasome accessory complex,nuclear proteasome complex,cytosolic proteasome complex,extracellular exosomeg>sp|P62333|PRS10_HUMAN 26S proteasome regulatory subunit 10B OS=Homo sapiens OX=9606 GN=PSMC6 PE=1 SV=1Q13308PTK7 PTK7_HUMAN"Inactive tyrosine-protein kinase 7'establishment of planar polarity,ventricular septum development,axis elongation,protein phosphorylation,cell adhesion,signal transduction,positive regulation of neuron projection development,cell migration,actin cytoskeleton reorganization,wound healing,establishment of epithelial cell apical/basal polarity,convergent extension,canonical Wnt signaling pathway,lung-associated mesenchyme development,coronary vasculature development,cellular response to retinoic acid,cochlea morphogenesis,planar cell polarity pathway involved in neural tube closureprotein kinase activity,protein binding,ATP binding,coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathwayGintegral component of plasma membrane,cell-cell junction,focal adhesionb>sp|Q13308|PTK7_HUMAN Inactive tyrosine-protein kinase 7 OS=Homo sapiens OX=9606 GN=PTK7 PE=1 SV=2P07195LDHB LDHB_HUMANL-lactate dehydrogenase B chaincarbohydrate metabolic process,lactate metabolic process,pyruvate metabolic process,NAD metabolic process,oxidation-reduction processeL-lactate dehydrogenase activity,protein binding,kinase binding,identical protein binding,NAD bindingZcytoplasm,mitochondrion,cytosol,membrane,myelin sheath,membrane raft,extracellular exosome_>sp|P07195|LDHB_HUMAN L-lactate dehydrogenase B chain OS=Homo sapiens OX=9606 GN=LDHB PE=1 SV=2O00560SDCBP SDCB1_HUMAN Syntenin-1negative regulation of receptor internalization,protein targeting to membrane,substrate-dependent cell migration, cell extension,chemical synaptic transmission,regulation of mitotic cell cycle,positive regulation of cell proliferation,positive regulation of epithelial to mesenchymal transition,positive regulation of pathway-restricted SMAD protein phosphorylation,actin cytoskeleton organization,positive regulation of cell growth,positive regulation of cell migration,positive regulation of transforming gr< owth factor beta receptor signaling pathway,negative regulation of proteasomal ubiquitin-dependent protein catabolic process,intracellular signal transduction,positive regulation of phosphorylation,neutrophil degranulation,positive regulation of JNK cascade,ephrin receptor signaling pathway,positive regulation of exosomal secretion,positive regulation of extracellular exosome assemblyfrizzled binding,interleukin-5 receptor binding,protein binding,phosphatidylinositol-4,5-bisphosphate binding,cytoskeletal adaptor activity,identical protein binding,cadherin binding,syndecan binding,protein heterodimerization activity,protein N-terminus binding~extracellular region,extracellular space,nucleus,nucleoplasm,cytoplasm,endoplasmic reticulum membrane,cytosol,cytoskeleton,plasma membrane,interleukin-5 receptor complex,adherens junction,focal adhesion,membrane,nuclear membrane,azurophil granule lumen,melanosome,intracellular membrane-bounded organelle,membrane raft,extracellular exosome,blood microparticle,extracellular vesicleL>sp|O00560|SDCB1_HUMAN Syntenin-1 OS=Homo sapiens OX=9606 GN=SDCBP PE=1 SV=1P09619PDGFRB PGFRB_HUMAN,Platelet-derived growth factor receptor beta MAPK cascade,glycosaminoglycan biosynthetic process,signal transduction,G-protein coupled receptor signaling pathway,aging,positive regulation of cell proliferation,male gonad development,response to toxic substance,positive regulation of phospholipase C activity,regulation of phosphatidylinositol 3-kinase signaling,positive regulation of phosphatidylinositol 3-kinase signaling,positive regulation of smooth muscle cell migration,cell migration,peptidyl-tyrosine phosphorylation,positive regulation of cell migration,response to estradiol,positive regulation of phosphoprotein phosphatase activity,response to retinoic acid,regulation of actin cytoskeleton organization,positive regulation of collagen biosynthetic process,response to fluid shear stress,positive regulation of Rho protein signal transduction,cell migration involved in vasculogenesis,metanephric mesenchymal cell migration,platelet-derived growth factor receptor-beta signaling pathway,positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway,aorta morphogenesis,cellular response to platelet-derived growth factor stimulus,positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway,wound healing,response to hydrogen peroxide,positive regulation of apoptotic process,negative regulation of apoptotic process,positive regulation of MAP kinase activity,positive regulation of GTPase activity,positive regulation of phosphatidylinositol 3-kinase activity,response to estrogen,positive regulation of mitotic nuclear division,phosphatidylinositol metabolic process,protein autophosphorylation,phosphatidylinositol phosphorylation,platelet-derived growth factor receptor signaling pathway,phosphatidylinositol-mediated signaling,positive regulation of fibroblast proliferation,positive regulation of smooth muscle cell proliferation,inner ear development,positive regulation of chemotaxis,cardiac myofibril assembly,response to hyperoxia,cell chemotaxis,lung growth,cell migration involved in coronary angiogenesis,retina vasculature development in camera-type eye,positive regulation of ERK1 and ERK2 cascade,smooth muscle cell chemotaxis,metanephric mesenchyme development,metanephric glomerular mesangial cell proliferation involved in metanephros development,metanephric glomerular capillary formation,metanephric comma-shaped body morphogenesis,metanephric S-shaped body morphogenesis,positive regulation of calcium ion import,positive regulation of reactive oxygen species metabolic process,positive regulation of hepatic stellate cell activation,positive regulation of DNA biosynthetic process,negative regulation of platelet-derived growth factor receptor-beta signaling pathway protein tyrosine kinase activity,platelet activating factor receptor activity,platelet-derived growth factor-activated receptor activity,platelet-derived growth factor beta-receptor activity,Ras guanyl-nucleotide exchange factor activity,receptor binding,platelet-derived growth factor receptor binding,protein binding,ATP binding,enzyme binding,protein kinase binding,vascular endothelial growth factor binding,phosphatidylinositol 3-kinase binding,phosphatidylinositol-4,5-bisphosphate 3-kinase activity,platelet-derived growth factor bindingnucleus,cytoplasm,plasma membrane,focal adhesion,cell surface,membrane,integral component of membrane,apical plasma membrane,intrinsic component of plasma membrane,cytoplasmic vesicle,lysosomal lumen,extracellular exosomeo>sp|P09619|PGFRB_HUMAN Platelet-derived growth factor receptor beta OS=Homo sapiens OX=9606 GN=PDGFRB PE=1 SV=1P35442THBS2 TSP2_HUMANThrombospondin-2Ycell adhesion,negative regulation of angiogenesis,positive regulation of synapse assemblyQextracellular region,basement membrane,extracellular space,platelet alpha granuleQ>sp|P35442|TSP2_HUMAN Thrombospondin-2 OS=Homo sapiens OX=9606 GN=THBS2 PE=1 SV=2P27797CALR CALR_HUMAN Calreticulinnegative regulation of transcription from RNA polymerase II promoter,antigen processing and presentation of peptide antigen via MHC class I,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent,peptide antigen assembly with MHC class I protein complex,regulation of transcription, DNA-templated,protein folding,protein export from nucleus,cellular calcium ion homeostasis,receptor-mediated endocytosis,spermatogenesis,positive regulation of cell proliferation,positive regulation of gene expression,negative regulation of translation,protein maturation by protein folding,cortical actin cytoskeleton organization,response to estradiol,negative regulation of intracellular steroid hormone receptor signaling pathway,response to testosterone,protein localization to nucleus,protein folding in endoplasmic reticulum,ATF6-mediated unfolded protein response,regulation of meiotic nuclear division,response to drug,glucocorticoid receptor signaling pathway,regulation of apoptotic process,negative regulation of neuron differentiation,positive regulation of DNA replication,positive regulation of cell cycle,negative regulation of transcription, DNA-templated,negative regulation of retinoic acid receptor signaling pathway,positive regulation of phagocytosis,protein stabilization,sequestering of calcium ion,cardiac muscle cell differentiation,chaperone-mediated protein folding,negative regulation of cell cycle arrest,cellular response to lithium ion,cellular senescence,positive regulation of substrate adhesion-dependent cell spreading,positive regulation of NIK/NF-kappaB signaling,vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane,positive regulation of dendritic cell chemotaxisxcomplement component C1q binding,glycoprotein binding,DNA binding,RNA binding,mRNA binding,integrin binding,iron ion binding,calcium ion binding,protein binding,zinc ion binding,carbohydrate binding,ubiquitin protein ligase binding,peptide binding,hormone binding,protein binding involved in protein folding,androgen receptor binding,unfolded protein binding,chaperone bindingaacrosomal vesicle,extracellular region,proteinaceous extracellular matrix,extracellular space,intracellular,nucleus,cytoplasm,endoplasmic reticulum,endoplasmic reticulum lumen,smooth endoplasmic reticulum,Golgi apparatus,cytosol,polysome,focal adhesion,external side of plasma membrane,cell surface,membrane,phagocytic vesicle membrane,sarcoplasmic reticulum lumen,endoplasmic reticulum-Golgi intermediate compartment membrane,MHC class I peptide loading complex,perinuclear region of cytoplasm,extracellular exosome,integral component of lumenal side of endoplasmic reticulum membrane,endocytic vesicle lumenL>sp|P27797|CALR_HUMAN Calreticulin OS=Homo sapiens OX=9606 GN=CALR PE=1 SV=1P60900PSMA6 PSA6_HUMANProteasome subunit alpha type-6)MAPK cascade,protein polyubiquitination,stimulatory C-type lectin receptor signaling pathway,antigen pr< ocessing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent,regulation of cellular amino acid metabolic process,negative regulation of G2/M transition of mitotic cell cycle,protein deubiquitination,anaphase-promoting complex-dependent catabolic process,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process,tumor necrosis factor-mediated signaling pathway,NIK/NF-kappaB signaling,Fc-epsilon receptor signaling pathway,proteasome-mediated ubiquitin-dependent protein catabolic process,regulation of mRNA stability,regulation of inflammatory response,T cell receptor signaling pathway,positive regulation of NF-kappaB transcription factor activity,negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition,proteolysis involved in cellular protein catabolic process,transmembrane transport,Wnt signaling pathway, planar cell polarity pathway,regulation of transcription from RNA polymerase II promoter in response to hypoxia,negative regulation of canonical Wnt signaling pathway,positive regulation of canonical Wnt signaling pathwayRNA binding,endopeptidase activity,threonine-type endopeptidase activity,protein binding,purine ribonucleoside triphosphate binding,NF-kappaB bindingproteasome complex,cytoplasmic mRNA processing body,nucleus,nucleoplasm,cytosol,proteasome core complex,polysome,nuclear matrix,proteasome core complex, alpha-subunit complex,myofibril,sarcomere,extracellular exosome`>sp|P60900|PSA6_HUMAN Proteasome subunit alpha type-6 OS=Homo sapiens OX=9606 GN=PSMA6 PE=1 SV=1P07384CAPN1 CAN1_HUMANCalpain-1 catalytic subunitproteolysis,positive regulation of cell proliferation,regulation of macroautophagy,extracellular matrix disassembly,receptor catabolic process,neutrophil degranulation,regulation of catalytic activity,mammary gland involution,cornification,self proteolysisextracellular region,mitochondrion,lysosome,cytosol,plasma membrane,focal adhesion,membrane,extracellular exosome,ficolin-1-rich granule lumen\>sp|P07384|CAN1_HUMAN Calpain-1 catalytic subunit OS=Homo sapiens OX=9606 GN=CAPN1 PE=1 SV=1P54289CACNA2D1 CA2D1_HUMAN9Voltage-dependent calcium channel subunit alpha-2/delta-1Zcalcium ion transport,regulation of calcium ion transport,regulation of ventricular cardiac muscle cell membrane repolarization,calcium ion transport into cytosol,cardiac conduction,calcium ion transmembrane transport via high voltage-gated calcium channel,cardiac muscle cell action potential involved in contraction,membrane depolarization during bundle of His cell action potential,regulation of heart rate by cardiac conduction,calcium ion import across plasma membrane,regulation of membrane repolarization during action potential,positive regulation of high voltage-gated calcium channel activityvoltage-gated calcium channel activity,metal ion binding,voltage-gated calcium channel activity involved in cardiac muscle cell action potential,voltage-gated calcium channel activity involved in bundle of His cell action potentialplasma membrane,voltage-gated calcium channel complex,sarcoplasmic reticulum,extracellular exosome,L-type voltage-gated calcium channel complex~>sp|P54289|CA2D1_HUMAN Voltage-dependent calcium channel subunit alpha-2/delta-1 OS=Homo sapiens OX=9606 GN=CACNA2D1 PE=1 SV=3P07602PSAP SAP_HUMAN Prosaposinplatelet degranulation,glycosphingolipid metabolic process,lipid transport,adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway,regulation of autophagy,regulation of lipid metabolic process,positive regulation of catalytic activity,neutrophil degranulation,positive regulation of MAPK cascade,prostate gland growth,epithelial cell differentiation involved in prostate gland development,cellular response to organic substance,negative regulation of hydrogen peroxide-induced cell deathZG-protein coupled receptor binding,protein binding,enzyme activator activity,lipid bindingextracellular region,extracellular space,mitochondrion,lysosome,lysosomal membrane,plasma membrane,integral component of membrane,azurophil granule membrane,lysosomal lumen,intracellular membrane-bounded organelle,extracellular exosomeI>sp|P07602|SAP_HUMAN Prosaposin OS=Homo sapiens OX=9606 GN=PSAP PE=1 SV=2P02649APOE APOE_HUMANApolipoprotein EJ response to reactive oxygen species,retinoid metabolic process,negative regulation of endothelial cell proliferation,response to dietary excess,regulation of transcription from RNA polymerase II promoter,triglyceride metabolic process,cholesterol catabolic process,cellular calcium ion homeostasis,receptor-mediated endocytosis,cytoskeleton organization,G-protein coupled receptor signaling pathway,nitric oxide mediated signal transduction,synaptic transmission, cholinergic,cholesterol metabolic process,negative regulation of platelet activation,positive regulation of cholesterol esterification,positive regulation of cholesterol efflux,lipid transport involved in lipid storage,positive regulation of neuron projection development,negative regulation of neuron projection development,long-chain fatty acid transport,protein import,virion assembly,triglyceride catabolic process,cGMP-mediated signaling,negative regulation of blood coagulation,regulation of axon extension,positive regulation of cGMP biosynthetic process,neuron projection regeneration,negative regulation of cellular protein metabolic process,regulation of Cdc42 protein signal transduction,positive regulation of low-density lipoprotein particle receptor catabolic process,cholesterol efflux,phospholipid efflux,very-low-density lipoprotein particle remodeling,low-density lipoprotein particle remodeling,high-density lipoprotein particle remodeling,high-density lipoprotein particle assembly,chylomicron remnant clearance,high-density lipoprotein particle clearance,very-low-density lipoprotein particle clearance,lipoprotein metabolic process,lipoprotein biosynthetic process,lipoprotein catabolic process,vasodilation,cholesterol homeostasis,negative regulation of MAP kinase activity,negative regulation of neuron apoptotic process,negative regulation of blood vessel endothelial cell migration,reverse cholesterol transport,positive regulation by host of viral process,negative regulation of cholesterol biosynthetic process,positive regulation of endocytosis,positive regulation of lipid biosynthetic process,intracellular transport,regulation of neuronal synaptic plasticity,artery morphogenesis,negative regulation of inflammatory response,positive regulation of nitric-oxide synthase activity,positive regulation of membrane protein ectodomain proteolysis,maintenance of location in cell,fatty acid homeostasis,positive regulation of dendritic spine development,triglyceride homeostasis,negative regulation of canonical Wnt signaling pathway,negative regulation of triglyceride metabolic process,AMPA glutamate receptor clustering,NMDA glutamate receptor clustering,cellular oxidant detoxification,regulation of beta-amyloid clearance,negative regulation of long-term synaptic potentiation,negative regulation of neuron death,positive regulation of postsynaptic membrane organization,negative regulation of presynaptic membrane organization,negative regulation of beta-amyloid formation,positive regulation of dendritic spine maintenance,positive regulation of phospholipid efflux,positive regulation of lipid transport across blood brain barrier,Requires Ontologybeta-amyloid binding,lipid transporter activity,protein binding,phospholipid binding,heparin binding,lipid binding,cholesterol binding,antioxidant activity,cholesterol transporter activity,identical protein binding,protein homodimerization activity,metal chelating activity,tau protein binding,low-density lipoprotein particle receptor binding,phosphatidylcholine-sterol O-acyltransferase activator activity,very-low-density lipoprotein particle receptor binding,lipoprotein particle bindingextracellular region,extracellular space,nucleus,cytoplasm,early endosome,endoplasmic reticulum,Golgi apparatus,plasma< membrane,membrane,dendrite,extracellular matrix,very-low-density lipoprotein particle,low-density lipoprotein particle,intermediate-density lipoprotein particle,high-density lipoprotein particle,chylomicron,neuronal cell body,extracellular exosome,endocytic vesicle lumen,blood microparticle,extracellular vesicleP>sp|P02649|APOE_HUMAN Apolipoprotein E OS=Homo sapiens OX=9606 GN=APOE PE=1 SV=1Q8N6Y2LRRC17 LRC17_HUMAN)Leucine-rich repeat-containing protein 17}negative regulation of osteoclast differentiation,bone marrow development,osteoblast differentiation,osteoblast proliferationl>sp|Q8N6Y2|LRC17_HUMAN Leucine-rich repeat-containing protein 17 OS=Homo sapiens OX=9606 GN=LRRC17 PE=2 SV=1P29992GNA11 GNA11_HUMAN3Guanine nucleotide-binding protein subunit alpha-11skeletal system development,action potential,signal transduction,adenylate cyclase-modulating G-protein coupled receptor signaling pathway,G-protein coupled acetylcholine receptor signaling pathway,heart development,phototransduction, visible light,entrainment of circadian clock,platelet activation,regulation of melanocyte differentiation,developmental pigmentation,phospholipase C-activating dopamine receptor signaling pathway,cellular response to pHGTPase activity,signal transducer activity,GTP binding,G-protein beta/gamma-subunit complex binding,type 2A serotonin receptor binding,metal ion bindingphotoreceptor outer segment,cytoplasm,lysosomal membrane,heterotrimeric G-protein complex,plasma membrane,extracellular exosomeu>sp|P29992|GNA11_HUMAN Guanine nucleotide-binding protein subunit alpha-11 OS=Homo sapiens OX=9606 GN=GNA11 PE=1 SV=2Q02878RPL6 RL6_HUMAN60S ribosomal protein L6,ribosomal large subunit assembly,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,cytoplasmic translation,regulation of transcription, DNA-templated,rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,viral transcriptionKDNA binding,RNA binding,structural constituent of ribosome,cadherin bindingonucleus,cytosol,focal adhesion,membrane,cytosolic large ribosomal subunit,cytoplasmic ribonucleoprotein granuleW>sp|Q02878|RL6_HUMAN 60S ribosomal protein L6 OS=Homo sapiens OX=9606 GN=RPL6 PE=1 SV=3P36871PGM1 PGM1_HUMANPhosphoglucomutase-1glycogen biosynthetic process,glycogen catabolic process,glucose metabolic process,gluconeogenesis,glycolytic process,galactose catabolic process,neutrophil degranulationAmagnesium ion binding,phosphoglucomutase activity,protein bindingextracellular region,cytoplasm,cytosol,actin cytoskeleton,extracellular exosome,tertiary granule lumen,ficolin-1-rich granule lumenT>sp|P36871|PGM1_HUMAN Phosphoglucomutase-1 OS=Homo sapiens OX=9606 GN=PGM1 PE=1 SV=3O15460P4HA2 P4HA2_HUMAN$Prolyl 4-hydroxylase subunit alpha-2:peptidyl-proline hydroxylation,oxidation-reduction processprocollagen-proline 4-dioxygenase activity,iron ion binding,electron carrier activity,oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen,L-ascorbic acid bindingnnucleoplasm,endoplasmic reticulum,endoplasmic reticulum lumen,cytosol,intracellular membrane-bounded organellef>sp|O15460|P4HA2_HUMAN Prolyl 4-hydroxylase subunit alpha-2 OS=Homo sapiens OX=9606 GN=P4HA2 PE=1 SV=1Q15818NPTX1 NPTX1_HUMANNeuronal pentraxin-1ptransport,chemical synaptic transmission,central nervous system development,axonogenesis involved in innervationmetal ion bindingtransport vesicleV>sp|Q15818|NPTX1_HUMAN Neuronal pentraxin-1 OS=Homo sapiens OX=9606 GN=NPTX1 PE=1 SV=2Q96TA1NIBAN2 NIBA2_HUMANProtein Niban 2(negative regulation of apoptotic processcadherin bindingSnucleoplasm,cytosol,plasma membrane,adherens junction,extracellular exosome,nucleusR>sp|Q96TA1|NIBA2_HUMAN Protein Niban 2 OS=Homo sapiens OX=9606 GN=NIBAN2 PE=1 SV=3P23526AHCY SAHH_HUMANAdenosylhomocysteinase*sulfur amino acid metabolic process,response to hypoxia,chronic inflammatory response to antigenic stimulus,one-carbon metabolic process,response to nutrient,S-adenosylhomocysteine catabolic process,methylation,S-adenosylmethionine cycle,circadian sleep/wake cycle,homocysteine biosynthetic processoadenosylhomocysteinase activity,protein binding,adenyl nucleotide binding,identical protein binding,NAD bindingBnucleus,cytosol,melanosome,neuron projection,extracellular exosomeV>sp|P23526|SAHH_HUMAN Adenosylhomocysteinase OS=Homo sapiens OX=9606 GN=AHCY PE=1 SV=4Q9Y4L1HYOU1 HYOU1_HUMANHypoxia up-regulated protein 1}response to ischemia,ER to Golgi vesicle-mediated transport,receptor-mediated endocytosis,response to endoplasmic reticulum stress,IRE1-mediated unfolded protein response,cellular response to hypoxia,negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway,negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathwayATP binding,chaperone bindingextracellular region,endoplasmic reticulum,endoplasmic reticulum lumen,smooth endoplasmic reticulum,focal adhesion,membrane,endoplasmic reticulum chaperone complex,extracellular exosome,endocytic vesicle lumen`>sp|Q9Y4L1|HYOU1_HUMAN Hypoxia up-regulated protein 1 OS=Homo sapiens OX=9606 GN=HYOU1 PE=1 SV=1Q08211DHX9 DHX9_HUMANATP-dependent RNA helicase AmRNA splicing, via spliceosome,osteoblast differentiation,RNA processing,positive regulation of type I interferon production,DNA duplex unwinding,rhythmic process,CRD-mediated mRNA stabilization,protein localization to cytoplasmic stress granuleRNA polymerase II transcription factor binding,DNA binding,RNA binding,RNA helicase activity,ATP-dependent DNA helicase activity,ATP-dependent RNA helicase activity,protein binding,ATP bindingnucleus,nucleoplasm,nucleolus,cytoplasm,centrosome,cytosol,membrane,intracellular ribonucleoprotein complex,cytoplasmic ribonucleoprotein granule,CRD-mediated mRNA stability complex,nuclear stress granule\>sp|Q08211|DHX9_HUMAN ATP-dependent RNA helicase A OS=Homo sapiens OX=9606 GN=DHX9 PE=1 SV=4Q969P0IGSF8 IGSF8_HUMAN#Immunoglobulin superfamily member 8movement of cell or subcellular component,single fertilization,nervous system development,skeletal muscle tissue development,cell proliferatione>sp|Q969P0|IGSF8_HUMAN Immunoglobulin superfamily member 8 OS=Homo sapiens OX=9606 GN=IGSF8 PE=1 SV=1P30153PPP2R1A 2AAA_HUMANQSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoformG2/M transition of mitotic cell cycle,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,inactivation of MAPK activity,regulation of DNA replication,regulation of transcription, DNA-templated,protein complex assembly,protein dephosphorylation,ceramide metabolic process,apoptotic process,chromosome segregation,mitotic nuclear envelope reassembly,female meiotic division,RNA splicing,response to organic substance,second-messenger-mediated signaling,regulation of Wnt signaling pathway,regulation of cell adhesion,negative regulation of cell growth,regulation of growth,negative regulation of tyrosine phosphorylation of Stat3 protein,regulation of cell differentiation,meiotic spindle elongation,mitotic sister chromatid separation,meiotic sister chromatid cohesion, centromeric,peptidyl-serine dephosphorylation,ciliary basal body docking,regulation of meiotic cell cycle process involved in oocyte maturation,positive regulation of extrinsic apoptotic signaling pathway in absence of ligandantigen binding,protein serine/threonine phosphatase activity,protein binding,protein phosphatase regulator activity,protein heterodimerization activityprotein phosphatase type 2A complex,chromosome, centromeric region,nucleus,mitochondrion,cytosol,microtubule cytoskeleton,membrane,extracellular exosome>sp|P30153|2AAA_HUMAN Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R1A PE=1 SV=4P41091EIF2S3 IF2G_HUMAN4Eukaryotic translation initiation factor 2 subunit 30translational initiat< ion,transmembrane transporttranslation initiation factor activity,GTPase activity,protein binding,GTP binding,translation factor activity, RNA binding,cadherin bindingbcytoplasm,cytosol,eukaryotic translation initiation factor 2 complex,extracellular exosome,nucleusv>sp|P41091|IF2G_HUMAN Eukaryotic translation initiation factor 2 subunit 3 OS=Homo sapiens OX=9606 GN=EIF2S3 PE=1 SV=3P11586MTHFD1 C1TC_HUMAN*C-1-tetrahydrofolate synthase, cytoplasmicUhistidine biosynthetic process,neutrophil homeostasis,neural tube closure,purine nucleotide biosynthetic process,methionine metabolic process,one-carbon metabolic process,heart development,serine family amino acid metabolic process,serine family amino acid biosynthetic process,methionine biosynthetic process,purine nucleobase biosynthetic process,10-formyltetrahydrofolate biosynthetic process,transsulfuration,tetrahydrofolate interconversion,folic acid metabolic process,embryonic neurocranium morphogenesis,embryonic viscerocranium morphogenesis,oxidation-reduction process,somite development!formate-tetrahydrofolate ligase activity,methenyltetrahydrofolate cyclohydrolase activity,methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity,methylenetetrahydrofolate dehydrogenase (NAD+) activity,methylenetetrahydrofolate dehydrogenase (NADP+) activity,protein binding,ATP binding>cytoplasm,mitochondrion,cytosol,membrane,extracellular exosomel>sp|P11586|C1TC_HUMAN C-1-tetrahydrofolate synthase, cytoplasmic OS=Homo sapiens OX=9606 GN=MTHFD1 PE=1 SV=4Q9UJ70NAGK NAGK_HUMANN-acetyl-D-glucosamine kinaseN-acetylglucosamine metabolic process,UDP-N-acetylglucosamine biosynthetic process,N-acetylmannosamine metabolic process,N-acetylneuraminate catabolic process,carbohydrate phosphorylationaprotein binding,ATP binding,N-acylmannosamine kinase activity,N-acetylglucosamine kinase activity]>sp|Q9UJ70|NAGK_HUMAN N-acetyl-D-glucosamine kinase OS=Homo sapiens OX=9606 GN=NAGK PE=1 SV=4P26006ITGA3 ITA3_HUMANIntegrin alpha-3neuron migration,cell-matrix adhesion,integrin-mediated signaling pathway,heart development,memory,positive regulation of gene expression,positive regulation of epithelial cell migration,positive regulation of cell-substrate adhesion,positive regulation of neuron projection development,regulation of transforming growth factor beta receptor signaling pathway,regulation of Wnt signaling pathway,extracellular matrix organization,lung development,regulation of BMP signaling pathway,negative regulation of cell projection organization,response to gonadotropin,negative regulation of Rho protein signal transduction,exploration behavior,response to drug,skin development,mesodermal cell differentiation,leukocyte migration,maternal process involved in female pregnancy,nephron development,positive regulation of establishment of protein localization to plasma membrane,dendritic spine maintenance,renal filtrationglycoprotein binding,fibronectin binding,protease binding,integrin binding,protein binding,collagen binding,protein domain specific binding,laminin binding,metal ion binding,protein heterodimerization activityHplasma membrane,focal adhesion,integrin complex,external side of plasma membrane,cell surface,basolateral plasma membrane,growth cone,filopodium membrane,integrin alpha3-beta1 complex,receptor complex,perinuclear region of cytoplasm,excitatory synapse,extracellular exosome,invadopodium membrane,cell periphery,synaptic membraneQ>sp|P26006|ITA3_HUMAN Integrin alpha-3 OS=Homo sapiens OX=9606 GN=ITGA3 PE=1 SV=5Q16658FSCN1 FSCN1_HUMANFascincell-cell junction assembly,cell proliferation,anatomical structure morphogenesis,positive regulation of lamellipodium assembly,cell migration,microspike assembly,actin cytoskeleton organization,regulation of microvillus assembly,regulation of actin cytoskeleton organization,establishment of apical/basal cell polarity,cell motility,actin filament bundle assembly,positive regulation of filopodium assembly,positive regulation of podosome assembly,positive regulation of extracellular matrix disassemblyxRNA binding,actin binding,protein binding,drug binding,protein binding, bridging,cadherin binding,actin filament bindingstress fiber,ruffle,podosome,cytoplasm,cytosol,cytoskeleton,microvillus,cell-cell junction,actin cytoskeleton,lamellipodium,filopodium,growth cone,cell projection membrane,filamentous actin,myelin sheath,microspike,extracellular exosome,invadopodiumH>sp|Q16658|FSCN1_HUMAN Fascin OS=Homo sapiens OX=9606 GN=FSCN1 PE=1 SV=3P27105STOM STOM_HUMANStomatinneutrophil degranulation,positive regulation by host of viral genome replication,protein homooligomerization,positive regulation of protein targeting to membrane,regulation of acid-sensing ion channel activityHprotein binding,protein homodimerization activity,RNA polymerase bindingEextracellular space,mitochondrion,endoplasmic reticulum,cytosol,cytoskeleton,plasma membrane,integral component of plasma membrane,membrane,vesicle,azurophil granule membrane,specific granule membrane,melanosome,membrane raft,perinuclear region of cytoplasm,extracellular exosome,tertiary granule membrane,blood microparticleH>sp|P27105|STOM_HUMAN Stomatin OS=Homo sapiens OX=9606 GN=STOM PE=1 SV=3P56199ITGA1 ITA1_HUMANIntegrin alpha-1activation of MAPK activity,muscle contraction,cell-matrix adhesion,integrin-mediated signaling pathway,negative regulation of cell proliferation,extracellular matrix organization,neutrophil chemotaxis,positive regulation of phosphoprotein phosphatase activity,negative regulation of epidermal growth factor receptor signaling pathway,vasodilation,positive regulation of neuron apoptotic process,cellular extravasation,neuron projection morphogenesisreceptor binding,protein binding,collagen binding,protein phosphatase binding,metal ion binding,collagen binding involved in cell-matrix adhesionacrosomal vesicle,plasma membrane,focal adhesion,integrin complex,external side of plasma membrane,cell surface,membrane,integrin alpha1-beta1 complex,neuron projection,perikaryon,membrane raft,basal part of cell,extracellular exosomeQ>sp|P56199|ITA1_HUMAN Integrin alpha-1 OS=Homo sapiens OX=9606 GN=ITGA1 PE=1 SV=2P46976GYG1 GLYG_HUMAN Glycogenin-1Qglycogen biosynthetic process,glycogen catabolic process,neutrophil degranulationIprotein binding,glycogenin glucosyltransferase activity,metal ion bindingextracellular region,cytosol,membrane,secretory granule lumen,lysosomal lumen,extracellular exosome,ficolin-1-rich granule lumenL>sp|P46976|GLYG_HUMAN Glycogenin-1 OS=Homo sapiens OX=9606 GN=GYG1 PE=1 SV=4O75955FLOT1 FLOT1_HUMAN Flotillin-1lmembrane raft assembly,positive regulation of cytokine production,positive regulation of protein phosphorylation,regulation of receptor internalization,axonogenesis,extracellular matrix disassembly,positive regulation of protein binding,positive regulation of synaptic transmission, dopaminergic,positive regulation of interferon-beta production,dsRNA transport,positive regulation of heterotypic cell-cell adhesion,positive regulation of toll-like receptor 3 signaling pathway,response to endoplasmic reticulum stress,regulation of Rho protein signal transduction,plasma membrane raft assembly,positive regulation of endocytosis,positive regulation of skeletal muscle tissue development,protein homooligomerization,positive regulation of cell adhesion molecule production,protein kinase C signaling,cellular response to exogenous dsRNA,establishment of protein localization to plasma membrane,positive regulation of myoblast fusion,positive regulation of cell junction assembly,protein localization to membrane raft,positive regulation of cell-cell adhesion mediated by cadherin,regulation of toll-like receptor 4 signaling pathwayjprotease binding,protein binding,ionotropic glutamate receptor binding,protein heterodimerization activityuropod,lysosomal membrane,endosome,early endosome,microtubule organizing center,plasma membrane,caveola,cell-cell junction,cell-cell adherens junction,focal adhesion,membrane,integral component of membrane,basolateral plasma membrane,flotillin c< omplex,lamellipodium,cytoplasmic vesicle,centriolar satellite,sarcolemma,melanosome,cell-cell contact zone,membrane raft,extracellular exosome,apical plasma membrane,COP9 signalosome,cortical actin cytoskeletonM>sp|O75955|FLOT1_HUMAN Flotillin-1 OS=Homo sapiens OX=9606 GN=FLOT1 PE=1 SV=3Q16555DPYSL2 DPYL2_HUMAN%Dihydropyrimidinase-related protein 2nucleobase-containing compound metabolic process,endocytosis,cytoskeleton organization,signal transduction,nervous system development,axon guidance,brain development,regulation of axon extensionZdihydropyrimidinase activity,protein binding,microtubule binding,identical protein bindingBcytosol,plasma membrane,extracellular exosome,microtubule,membraneh>sp|Q16555|DPYL2_HUMAN Dihydropyrimidinase-related protein 2 OS=Homo sapiens OX=9606 GN=DPYSL2 PE=1 SV=1P36955SERPINF1 PEDF_HUMAN!Pigment epithelium-derived factorkidney development,multicellular organism development,aging,short-term memory,cell proliferation,response to acidic pH,negative regulation of endothelial cell migration,negative regulation of gene expression,negative regulation of endopeptidase activity,positive regulation of neuron projection development,negative regulation of angiogenesis,ovulation cycle,response to arsenic-containing substance,negative regulation of inflammatory response,positive regulation of neurogenesis,retina development in camera-type eye,negative regulation of epithelial cell proliferation involved in prostate gland development,cellular response to cobalt ion,cellular response to retinoic acid,cellular response to glucose stimulus,cellular response to dexamethasone stimulus,negative regulation of neuron deathextracellular region,basement membrane,extracellular space,melanosome,axon hillock,perinuclear region of cytoplasm,extracellular exosome,extracellular matrixe>sp|P36955|PEDF_HUMAN Pigment epithelium-derived factor OS=Homo sapiens OX=9606 GN=SERPINF1 PE=1 SV=4O60701UGDH UGDH_HUMANUDP-glucose 6-dehydrogenasegastrulation with mouth forming second,UDP-glucose metabolic process,glycosaminoglycan biosynthetic process,UDP-glucuronate biosynthetic process,oxidation-reduction processJUDP-glucose 6-dehydrogenase activity,electron carrier activity,NAD binding)nucleoplasm,cytosol,extracellular exosome[>sp|O60701|UGDH_HUMAN UDP-glucose 6-dehydrogenase OS=Homo sapiens OX=9606 GN=UGDH PE=1 SV=1O75367 MACROH2A1 H2AY_HUMANCore histone macro-H2A.1&negative regulation of transcription from RNA polymerase II promoter,nucleosome assembly,chromatin silencing,dosage compensation,chromatin modification,regulation of lipid metabolic process,negative regulation of histone phosphorylation,positive regulation of maintenance of mitotic sister chromatid cohesion,regulation of gene expression, epigenetic,positive regulation of keratinocyte differentiation,negative regulation of gene expression, epigenetic,positive regulation of gene expression, epigenetic,negative regulation of histone H3-K4 methylation,negative regulation of histone H3-K27 methylation,establishment of protein localization to chromatin,negative regulation of protein serine/threonine kinase activity,negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter,negative regulation of cell cycle G2/M phase transition,regulation of response to oxidative stress,negative regulation of protein localization to chromosome, telomeric region,regulation of cell growth,regulation of chromatin silencing at rDNArDNA binding,RNA polymerase II regulatory region sequence-specific DNA binding,RNA polymerase II core promoter sequence-specific DNA binding,core promoter sequence-specific DNA binding,DNA binding,protein binding,double-stranded methylated DNA binding,enzyme binding,protein kinase binding,protein serine/threonine kinase inhibitor activity,chromatin DNA binding,nucleosomal DNA binding,transcription regulatory region DNA binding,protein heterodimerization activitynuclear chromosome,nuclear chromosome, telomeric region,nucleosome,nuclear chromatin,condensed chromosome,sex chromatin,Barr body,nucleus,pericentric heterochromatin,nucleolus,extracellular exosome,ESC/E(Z) complex]>sp|O75367|H2AY_HUMAN Core histone macro-H2A.1 OS=Homo sapiens OX=9606 GN=MACROH2A1 PE=1 SV=4O94985CLSTN1 CSTN1_HUMAN Calsyntenin-1regulation of cell growth,cell adhesion,homophilic cell adhesion via plasma membrane adhesion molecules,positive regulation of synaptic transmission,positive regulation of synapse assemblyabeta-amyloid binding,calcium ion binding,protein binding,kinesin binding,X11-like protein bindingGolgi membrane,extracellular space,nucleus,endoplasmic reticulum membrane,cell surface,postsynaptic density,integral component of membrane,cell junction,cell projection,postsynaptic membrane,extracellular exosomeP>sp|O94985|CSTN1_HUMAN Calsyntenin-1 OS=Homo sapiens OX=9606 GN=CLSTN1 PE=1 SV=1O14980XPO1 XPO1_HUMAN Exportin-1ribosomal subunit export from nucleus,ribosomal large subunit export from nucleus,ribosomal small subunit export from nucleus,negative regulation of transcription from RNA polymerase II promoter,protein export from nucleus,sister chromatid cohesion,regulation of centrosome duplication,viral process,protein localization to nucleus,regulation of protein catabolic process,response to drug,regulation of mRNA stability,regulation of protein export from nucleus,mRNA transport,intracellular transport of virusRNA binding,nuclear export signal receptor activity,transporter activity,nucleocytoplasmic transporter activity,protein binding,Ran GTPase binding,protein domain specific bindingkinetochore,nucleus,nuclear envelope,annulate lamellae,nucleoplasm,nucleolus,cytoplasm,cytosol,Cajal body,membrane,intracellular ribonucleoprotein complex,nuclear membrane,intracellular membrane-bounded organelleJ>sp|O14980|XPO1_HUMAN Exportin-1 OS=Homo sapiens OX=9606 GN=XPO1 PE=1 SV=1P26641EEF1G EF1G_HUMANElongation factor 1-gamma*translational elongation,response to virusGtranslation elongation factor activity,protein binding,cadherin bindingNnucleus,cytoplasm,cytosol,membrane,extracellular exosome,endoplasmic reticulumZ>sp|P26641|EF1G_HUMAN Elongation factor 1-gamma OS=Homo sapiens OX=9606 GN=EEF1G PE=1 SV=3Q9NZN3EHD3 EHD3_HUMANEH domain-containing protein 3receptor recycling,blood coagulation,endocytic recycling,early endosome to Golgi transport,protein homooligomerization,regulation of cardiac muscle contraction,cilium morphogenesis,protein targeting to plasma membrane,regulation of cardiac muscle cell membrane potential,Golgi to lysosome transport,positive regulation of voltage-gated calcium channel activity,regulation of Golgi organization,regulation of cardiac conductionPnucleic acid binding,calcium ion binding,protein binding,ATP binding,GTP bindingnucleus,cytoplasm,cytosol,focal adhesion,endosome membrane,ciliary pocket membrane,endocytic vesicle,myelin sheath,perinuclear region of cytoplasm,recycling endosome membrane^>sp|Q9NZN3|EHD3_HUMAN EH domain-containing protein 3 OS=Homo sapiens OX=9606 GN=EHD3 PE=1 SV=2P60228EIF3E EIF3E_HUMAN4Eukaryotic translation initiation factor 3 subunit Enuclear-transcribed mRNA catabolic process, nonsense-mediated decay,translational initiation,regulation of translational initiation,positive regulation of translation,negative regulation of translational initiation,positive regulation of mRNA bindingnRNA binding,translation initiation factor activity,protein binding,cadherin binding,protein N-terminus bindingnucleus,nucleoplasm,cytoplasm,cytosol,eukaryotic translation initiation factor 3 complex,membrane,nuclear body,extracellular exosome,chromatin,PML bodyv>sp|P60228|EIF3E_HUMAN Eukaryotic translation initiation factor 3 subunit E OS=Homo sapiens OX=9606 GN=EIF3E PE=1 SV=1P04114APOB APOB_HUMANApolipoprotein B-100retinoid metabolic process,in utero embryonic development,toll-like receptor signaling pathway,triglyceride mobilization,receptor-mediated endocytosis,spermatogenesis,nervous system development,cholesterol metabolic process,fertilization,response to virus,response< to carbohydrate,post-embryonic development,response to selenium ion,positive regulation of gene expression,positive regulation of macrophage derived foam cell differentiation,positive regulation of lipid storage,positive regulation of cholesterol storage,triglyceride catabolic process,cholesterol transport,flagellated sperm motility,response to estradiol,response to lipopolysaccharide,cholesterol efflux,low-density lipoprotein particle remodeling,very-low-density lipoprotein particle assembly,low-density lipoprotein particle clearance,lipoprotein metabolic process,lipoprotein biosynthetic process,lipoprotein catabolic process,cholesterol homeostasis,lipoprotein transport,cellular protein catabolic process,regulation of cholesterol biosynthetic process,artery morphogenesis,leukocyte migration,membrane organization,cellular response to tumor necrosis factor,cellular response to prostaglandin stimulusprotein binding,phospholipid binding,heparin binding,cholesterol transporter activity,lipase binding,low-density lipoprotein particle receptor binding;extracellular region,extracellular space,cytoplasm,early endosome,endoplasmic reticulum lumen,endoplasmic reticulum membrane,smooth endoplasmic reticulum,cytosol,plasma membrane,endosome membrane,clathrin-coated endocytic vesicle membrane,endosome lumen,mature chylomicron,chylomicron remnant,very-low-density lipoprotein particle,low-density lipoprotein particle,intermediate-density lipoprotein particle,chylomicron,neuronal cell body,lysosomal lumen,intracellular membrane-bounded organelle,extracellular exosome,endoplasmic reticulum exit site,endocytic vesicle lumenT>sp|P04114|APOB_HUMAN Apolipoprotein B-100 OS=Homo sapiens OX=9606 GN=APOB PE=1 SV=2P07900HSP90AA1 HS90A_HUMANHeat shock protein HSP 90-alphaG2/M transition of mitotic cell cycle,mitochondrial transport,receptor-mediated endocytosis,response to unfolded protein,telomere maintenance via telomerase,signal transduction,response to heat,response to cold,peptidyl-tyrosine phosphorylation,regulation of protein ubiquitination,Fc-gamma receptor signaling pathway involved in phagocytosis,ERBB2 signaling pathway,protein refolding,regulation of protein complex assembly,neutrophil degranulation,protein unfolding,protein import into mitochondrial outer membrane,positive regulation of nitric oxide biosynthetic process,response to antibiotic,vascular endothelial growth factor receptor signaling pathway,protein stabilization,regulation of nitric-oxide synthase activity,chaperone-mediated protein complex assembly,positive regulation of telomerase activity,chaperone-mediated autophagy,ciliary basal body docking,regulation of cellular response to heat,telomerase holoenzyme complex assemblynucleotide binding,RNA binding,protein tyrosine kinase activity,protein binding,ATP binding,ATPase activity,MHC class II protein complex binding,nitric-oxide synthase regulator activity,TPR domain binding,identical protein binding,protein homodimerization activity,histone deacetylase binding,GTPase binding,unfolded protein binding,DNA polymerase binding,protein tyrosine kinase bindingextracellular region,nucleus,nucleoplasm,cytoplasm,cytosol,plasma membrane,membrane,ruffle membrane,secretory granule lumen,melanosome,lysosomal lumen,myelin sheath,extracellular exosome,endocytic vesicle lumen,ficolin-1-rich granule lumend>sp|P07900|HS90A_HUMAN Heat shock protein HSP 90-alpha OS=Homo sapiens OX=9606 GN=HSP90AA1 PE=1 SV=5P46459NSF NSF_HUMANVesicle-fusing ATPaserpositive regulation of receptor recycling,potassium ion transport,intracellular protein transport,exocytosis,ER to Golgi vesicle-mediated transport,retrograde vesicle-mediated transport, Golgi to ER,vesicle-mediated transport,regulation of exocytosis,SNARE complex disassembly,plasma membrane fusion,positive regulation of protein catabolic process,COPII vesicle coatingSNARE binding,protein binding,ATP binding,ATPase activity,syntaxin-1 binding,Rab GTPase binding,protein kinase binding,PDZ domain binding,protein complex binding,ionotropic glutamate receptor binding,ATPase activity, coupled,metal ion bindingGolgi membrane,lysosomal membrane,Golgi stack,cytosol,plasma membrane,postsynaptic density,dendritic shaft,myelin sheath,extracellular exosomeS>sp|P46459|NSF_HUMAN Vesicle-fusing ATPase OS=Homo sapiens OX=9606 GN=NSF PE=1 SV=3P62280RPS11 RS11_HUMAN40S ribosomal protein S11nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,osteoblast differentiation,rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,viral transcriptionnucleoplasm,nucleolus,cytoplasm,cytosol,ribosome,focal adhesion,membrane,cytosolic small ribosomal subunit,extracellular matrix,extracellular exosomeZ>sp|P62280|RS11_HUMAN 40S ribosomal protein S11 OS=Homo sapiens OX=9606 GN=RPS11 PE=1 SV=3Q16270IGFBP7 IBP7_HUMAN,Insulin-like growth factor-binding protein 7regulation of cell growth,cell adhesion,embryo implantation,negative regulation of cell proliferation,response to heat,response to retinoic acid,cellular response to hormone stimulus,regulation of steroid biosynthetic process,response to cortisol2protein binding,insulin-like growth factor bindingSextracellular region,extracellular space,extracellular exosome,extracellular matrixn>sp|Q16270|IBP7_HUMAN Insulin-like growth factor-binding protein 7 OS=Homo sapiens OX=9606 GN=IGFBP7 PE=1 SV=1P13807GYS1 GYS1_HUMAN"Glycogen [starch] synthase, muscle/glycogen biosynthetic process,heart developmentglycogen (starch) synthase activity,protein binding,glucose binding,protein kinase binding,glycogen synthase activity, transferring glucose-1-phosphatecytosol,membrane,inclusion bodyb>sp|P13807|GYS1_HUMAN Glycogen [starch] synthase, muscle OS=Homo sapiens OX=9606 GN=GYS1 PE=1 SV=2P16234PDGFRA PGFRA_HUMAN-Platelet-derived growth factor receptor alphaMAPK cascade,luteinization,cell activation,positive regulation of cytosolic calcium ion concentration,positive regulation of cell proliferation,negative regulation of platelet activation,positive regulation of phospholipase C activity,regulation of phosphatidylinositol 3-kinase signaling,positive regulation of phosphatidylinositol 3-kinase signaling,viral process,peptidyl-tyrosine phosphorylation,positive regulation of cell migration,cellular response to reactive oxygen species,platelet-derived growth factor receptor-alpha signaling pathway,positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway,wound healing,positive regulation of GTPase activity,positive regulation of phosphatidylinositol 3-kinase activity,positive regulation of DNA replication,protein autophosphorylation,phosphatidylinositol phosphorylation,platelet-derived growth factor receptor signaling pathway,phosphatidylinositol-mediated signaling,positive regulation of fibroblast proliferation,embryonic digestive tract morphogenesis,embryonic cranial skeleton morphogenesis,embryonic skeletal system morphogenesis,regulation of chemotaxis,cardiac myofibril assembly,cell chemotaxis,retina vasculature development in camera-type eye,positive regulation of ERK1 and ERK2 cascade,platelet aggregation,metanephric glomerular capillary formation,regulation of actin cytoskeleton reorganization,negative regulation of platelet-derived growth factor receptor-beta signaling pathway,regulation of mesenchymal stem cell differentiationprotein kinase activity,transmembrane receptor protein tyrosine kinase activity,platelet-derived growth factor alpha-receptor activity,vascular endothelial growth factor-activated receptor activity,Ras guanyl-nucleotide exchange factor activity,platelet-derived growth factor receptor binding,protein binding,ATP binding,vascular endothelial growth factor binding,protein homodimerization activity,phosphatidylinositol-4,5-bisphosphate 3-kinase activity,platelet-derived growth factor bindingnucleus,cytoplasm,plasma membrane,integral component of plasma membrane,membrane,cell junction,intrinsic component of plasma membrane,protein complexp>sp|P16234|PGFRA_HUMAN Platelet-< derived growth factor receptor alpha OS=Homo sapiens OX=9606 GN=PDGFRA PE=1 SV=1P07093SERPINE2 GDN_HUMANGlia-derived nexinblood coagulation,negative regulation of cell proliferation,negative regulation of plasminogen activation,negative regulation of sodium ion transport,negative regulation of endopeptidase activity,negative regulation of protein processing,negative regulation of phosphatidylinositol 3-kinase signaling,cerebellar granular layer morphogenesis,negative regulation of blood coagulation,negative regulation of cell growth,regulation of cell migration,secretion by cell,secretory granule organization,negative regulation of protein catabolic process,mating plug formation,negative regulation of proteolysis,negative regulation of smoothened signaling pathway,regulation of timing of cell differentiation,positive regulation of astrocyte differentiation,detection of mechanical stimulus involved in sensory perception,regulation of synaptic transmission, glutamatergic,long-term synaptic potentiation,innervation,seminal vesicle epithelium development,negative regulation of platelet aggregationwserine-type endopeptidase inhibitor activity,receptor binding,protein binding,glycosaminoglycan binding,heparin bindingextracellular region,extracellular space,cytosol,extracellular matrix,platelet alpha granule,extrinsic component of external side of plasma membrane,neuromuscular junction,extracellular vesicleU>sp|P07093|GDN_HUMAN Glia-derived nexin OS=Homo sapiens OX=9606 GN=SERPINE2 PE=1 SV=1P05362ICAM1 ICAM1_HUMAN!Intercellular adhesion molecule 1?ovarian follicle development,regulation of leukocyte mediated cytotoxicity,response to amphetamine,T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell,acute inflammatory response to antigenic stimulus,T cell antigen processing and presentation,positive regulation of cellular extravasation,cell adhesion,heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules,leukocyte cell-cell adhesion,cell aging,sensory perception of sound,regulation of cell shape,response to ionizing radiation,response to sulfur dioxide,membrane to membrane docking,extracellular matrix organization,positive regulation of actin filament polymerization,cellular response to nutrient levels,response to insulin,cell adhesion mediated by integrin,response to gonadotropin,response to drug,response to amino acid,positive regulation of GTPase activity,adhesion of symbiont to host,positive regulation of nitric oxide biosynthetic process,response to ethanol,positive regulation of vasoconstriction,response to copper ion,viral entry into host cell,receptor-mediated virion attachment to host cell,positive regulation of peptidyl-tyrosine phosphorylation,regulation of immune response,leukocyte migration,positive regulation of NF-kappaB transcription factor activity,negative regulation of calcium ion transport,interferon-gamma-mediated signaling pathway,establishment of endothelial barrier,positive regulation of ERK1 and ERK2 cascade,cellular response to lipopolysaccharide,cellular response to alkaloid,cellular response to glucose stimulus,cellular response to interleukin-1,cellular response to interleukin-6,cellular response to tumor necrosis factor,cellular response to hypoxia,cellular response to dexamethasone stimulus,establishment of endothelial intestinal barrier,establishment of Sertoli cell barrier,regulation of ruffle assembly,negative regulation of extrinsic apoptotic signaling pathway via death domain receptors,positive regulation of leukocyte adhesion to vascular endothelial cell,negative regulation of endothelial cell apoptotic processtvirus receptor activity,receptor activity,transmembrane signaling receptor activity,integrin binding,protein bindingimmunological synapse,extracellular space,plasma membrane,integral component of plasma membrane,focal adhesion,external side of plasma membrane,cell surface,membrane,membrane raft,extracellular exosomec>sp|P05362|ICAM1_HUMAN Intercellular adhesion molecule 1 OS=Homo sapiens OX=9606 GN=ICAM1 PE=1 SV=2P10909CLU CLUS_HUMAN Clusterin5cell morphogenesis,microglial cell activation,release of cytochrome c from mitochondria,platelet degranulation,lipid metabolic process,complement activation,complement activation, classical pathway,response to virus,protein import,antimicrobial humoral response,central nervous system myelin maintenance,positive regulation of proteasomal ubiquitin-dependent protein catabolic process,negative regulation of protein homooligomerization,positive regulation of protein homooligomerization,positive regulation of tumor necrosis factor production,reverse cholesterol transport,innate immune response,positive regulation of nitric oxide biosynthetic process,protein stabilization,positive regulation of NF-kappaB transcription factor activity,chaperone-mediated protein complex assembly,response to misfolded protein,negative regulation of cell death,chaperone-mediated protein folding,microglial cell proliferation,negative regulation of release of cytochrome c from mitochondria,regulation of beta-amyloid clearance,regulation of neuron death,positive regulation of neuron death,positive regulation of beta-amyloid formation,negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage,negative regulation of beta-amyloid formation,regulation of neuronal signal transduction,positive regulation of tau-protein kinase activity,positive regulation of neurofibrillary tangle assembly,negative regulation of response to endoplasmic reticulum stress,Requires Ontology,positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processlprotein binding,ubiquitin protein ligase binding,chaperone binding,misfolded protein binding,ATPase activityextracellular region,extracellular space,nucleus,cytoplasm,mitochondrion,endoplasmic reticulum,Golgi apparatus,cytosol,cell surface,extracellular matrix,platelet alpha granule lumen,mitochondrial membrane,spherical high-density lipoprotein particle,chromaffin granule,protein complex,perinuclear region of cytoplasm,extracellular exosome,blood microparticle,neurofibrillary tangle,apical dendrite,cell peripheryH>sp|P10909|CLUS_HUMAN Clusterin OS=Homo sapiens OX=9606 GN=CLU PE=1 SV=1P11940PABPC1 PABP1_HUMANPolyadenylate-binding protein 1^nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,nuclear-transcribed mRNA poly(A) tail shortening,mRNA splicing, via spliceosome,mRNA polyadenylation,translational initiation,gene silencing by RNA,regulation of mRNA stability,positive regulation of viral genome replication,positive regulation of translation,mRNA stabilization,positive regulation of nuclear-transcribed mRNA poly(A) tail shortening,positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay,negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decaynucleotide binding,RNA binding,mRNA 3'-UTR binding,protein binding,protein C-terminus binding,poly(A) binding,poly(U) RNA binding,translation activator activitynucleus,cytoplasm,cytosol,focal adhesion,cytoplasmic stress granule,membrane,intracellular ribonucleoprotein complex,cytoplasmic ribonucleoprotein granule,extracellular exosome,catalytic step 2 spliceosomeb>sp|P11940|PABP1_HUMAN Polyadenylate-binding protein 1 OS=Homo sapiens OX=9606 GN=PABPC1 PE=1 SV=2Q9Y265RUVBL1 RUVB1_HUMAN RuvB-like 1DNA repair,DNA recombination,transcription, DNA-templated,regulation of transcription from RNA polymerase II promoter,mitotic nuclear division,spermatogenesis,protein deubiquitination,DNA duplex unwinding,CENP-A containing nucleosome assembly,regulation of growth,histone H4 acetylation,histone H2A acetylation,cell division,regulation of mitophagy,positive regulation of protein targeting to mitochondrion,beta-catenin-TCF complex assembly,positive regulation of telomerase RNA localization to Cajal body|DNA helicase activity,protein binding,ATP binding,ATPase activity,ATP-dependent 5'-3' DNA helicase activity,cadherin bindingSwr1 complex,nucleus,nuc< leoplasm,microtubule organizing center,cytosol,membrane,nuclear matrix,Ino80 complex,NuA4 histone acetyltransferase complex,extracellular exosome,MLL1 complex,R2TP complexN>sp|Q9Y265|RUVB1_HUMAN RuvB-like 1 OS=Homo sapiens OX=9606 GN=RUVBL1 PE=1 SV=1O14818PSMA7 PSA7_HUMANProteasome subunit alpha type-7MAPK cascade,protein polyubiquitination,stimulatory C-type lectin receptor signaling pathway,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent,regulation of cellular amino acid metabolic process,negative regulation of G2/M transition of mitotic cell cycle,viral process,protein deubiquitination,anaphase-promoting complex-dependent catabolic process,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process,tumor necrosis factor-mediated signaling pathway,NIK/NF-kappaB signaling,Fc-epsilon receptor signaling pathway,proteasome-mediated ubiquitin-dependent protein catabolic process,regulation of mRNA stability,T cell receptor signaling pathway,negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition,transmembrane transport,Wnt signaling pathway, planar cell polarity pathway,regulation of transcription from RNA polymerase II promoter in response to hypoxia,negative regulation of canonical Wnt signaling pathway,positive regulation of canonical Wnt signaling pathwayOthreonine-type endopeptidase activity,protein binding,identical protein bindingproteasome complex,nucleus,nucleoplasm,cytosol,proteasome core complex,proteasome core complex, alpha-subunit complex,extracellular exosome,postsynapse`>sp|O14818|PSA7_HUMAN Proteasome subunit alpha type-7 OS=Homo sapiens OX=9606 GN=PSMA7 PE=1 SV=1P08648ITGA5 ITA5_HUMANIntegrin alpha-5angiogenesis,cell-substrate junction assembly,cell adhesion,heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules,leukocyte cell-cell adhesion,integrin-mediated signaling pathway,memory,positive regulation of cell-substrate adhesion,extracellular matrix organization,positive regulation of cell migration,positive regulation of vascular endothelial growth factor receptor signaling pathway,cell-substrate adhesion,cell adhesion mediated by integrin,cell-cell adhesion mediated by integrin,heterotypic cell-cell adhesion,wound healing, spreading of epidermal cells,endodermal cell differentiation,viral entry into host cell,positive regulation of peptidyl-tyrosine phosphorylation,leukocyte migration,positive regulation of sprouting angiogenesis,negative regulation of anoikisvirus receptor activity,epidermal growth factor receptor binding,platelet-derived growth factor receptor binding,integrin binding,protein binding,vascular endothelial growth factor receptor 2 binding,metal ion bindingruffle,endoplasmic reticulum,Golgi apparatus,plasma membrane,focal adhesion,integrin complex,external side of plasma membrane,cell surface,cytoplasmic vesicle,synapse,alphav-beta3 integrin-vitronectin complex,cell-cell junction,ruffle membraneQ>sp|P08648|ITA5_HUMAN Integrin alpha-5 OS=Homo sapiens OX=9606 GN=ITGA5 PE=1 SV=2P51149RAB7A RAB7A_HUMANRas-related protein Rab-7a7protein targeting to lysosome,endocytosis,epidermal growth factor catabolic process,small GTPase mediated signal transduction,endosome to lysosome transport,protein transport,viral release from host cell,antigen processing and presentation of exogenous peptide antigen via MHC class II,protein to membrane docking,retrograde transport, endosome to Golgi,neutrophil degranulation,early endosome to late endosome transport,positive regulation of protein catabolic process,positive regulation of viral process,membrane organization,lipophagy,phagosome maturation,phagosome acidification,phagosome-lysosome fusion,multi-organism intracellular transport,negative regulation of exosomal secretion,positive regulation of exosomal secretion,negative regulation of intralumenal vesicle formation,regulation of autophagosome assemblyPGTPase activity,protein binding,GTP binding,GDP binding,retromer complex bindingtautophagosome membrane,lysosome,lysosomal membrane,late endosome,Golgi apparatus,lipid particle,cytosol,plasma membrane,endosome membrane,secretory granule membrane,phagocytic vesicle membrane,late endosome membrane,extrinsic component of lysosome membrane,melanosome membrane,pre-autophagosomal structure membrane,phagocytic vesicle,extracellular exosome,retromer complex\>sp|P51149|RAB7A_HUMAN Ras-related protein Rab-7a OS=Homo sapiens OX=9606 GN=RAB7A PE=1 SV=1P67936TPM4 TPM4_HUMANTropomyosin alpha-4 chainosteoblast differentiation,movement of cell or subcellular component,muscle contraction,actin filament organization,muscle filament sliding[calcium ion binding,protein binding,structural constituent of muscle,actin filament bindingstress fiber,podosome,cytosol,cytoskeleton,muscle thin filament tropomyosin,actin filament,focal adhesion,membrane,cortical cytoskeleton,filamentous actin,extracellular exosomeY>sp|P67936|TPM4_HUMAN Tropomyosin alpha-4 chain OS=Homo sapiens OX=9606 GN=TPM4 PE=1 SV=3Q99536VAT1 VAT1_HUMAN/Synaptic vesicle membrane protein VAT-1 homolog`negative regulation of mitochondrial fusion,neutrophil degranulation,oxidation-reduction process(zinc ion binding,oxidoreductase activity~extracellular region,mitochondrial outer membrane,integral component of membrane,azurophil granule lumen,extracellular exosomeo>sp|Q99536|VAT1_HUMAN Synaptic vesicle membrane protein VAT-1 homolog OS=Homo sapiens OX=9606 GN=VAT1 PE=1 SV=2Q14974KPNB1 IMB1_HUMANImportin subunit beta-1protein import into nucleus, translocation,apoptotic DNA fragmentation,protein import into nucleus,NLS-bearing protein import into nucleus,ribosomal protein import into nucleus,mitotic chromosome movement towards spindle pole,mitotic metaphase plate congression,modulation by virus of host process,astral microtubule organization,Ran protein signal transduction,establishment of mitotic spindle localization,neutrophil degranulation,establishment of protein localization,intracellular transport of virus,mitotic spindle assemblyRNA binding,protein binding,nuclear localization sequence binding,zinc ion binding,Ran GTPase binding,protein transporter activity,enzyme binding,protein domain specific binding,Hsp90 protein bindingextracellular region,nuclear envelope,nuclear pore,nucleoplasm,cytoplasm,cytosol,membrane,nuclear membrane,nuclear periphery,specific granule lumen,extracellular exosome,endoplasmic reticulum tubular network,ficolin-1-rich granule lumenX>sp|Q14974|IMB1_HUMAN Importin subunit beta-1 OS=Homo sapiens OX=9606 GN=KPNB1 PE=1 SV=2P07686HEXB HEXB_HUMAN Beta-hexosaminidase subunit betaskeletal system development,glycosphingolipid metabolic process,ganglioside catabolic process,cellular calcium ion homeostasis,lysosome organization,penetration of zona pellucida,sensory perception of sound,locomotory behavior,male courtship behavior,regulation of cell shape,phospholipid biosynthetic process,oligosaccharide catabolic process,lipid storage,chondroitin sulfate catabolic process,hyaluronan catabolic process,keratan sulfate catabolic process,myelination,neutrophil degranulation,astrocyte cell migration,cellular protein metabolic process,positive regulation of transcription from RNA polymerase II promoter,oogenesis,neuromuscular process controlling balancebeta-N-acetylhexosaminidase activity,acetylglucosaminyltransferase activity,protein homodimerization activity,protein heterodimerization activityacrosomal vesicle,extracellular region,extracellular space,membrane,azurophil granule lumen,azurophil granule,lysosomal lumen,extracellular exosome`>sp|P07686|HEXB_HUMAN Beta-hexosaminidase subunit beta OS=Homo sapiens OX=9606 GN=HEXB PE=1 SV=3O60568PLOD3 PLOD3_HUMANJMultifunctional procollagen lysine hydroxylase and glycosyltransferase LH3in utero embryonic development,endothelial cell morphogenesis,protein localization,neural tube development,collagen fibril organization,cellular response t< o hormone stimulus,vasodilation,epidermis morphogenesis,oxidation-reduction process,lung morphogenesis,basement membrane assemblyiron ion binding,protein binding,procollagen-lysine 5-dioxygenase activity,L-ascorbic acid binding,procollagen glucosyltransferase activity,procollagen galactosyltransferase activityYendoplasmic reticulum membrane,rough endoplasmic reticulum membrane,extracellular exosome>sp|O60568|PLOD3_HUMAN Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 OS=Homo sapiens OX=9606 GN=PLOD3 PE=1 SV=1Q14393GAS6 GAS6_HUMAN Growth arrest-specific protein 6 neuron migration,positive regulation of protein phosphorylation,positive regulation of cytokine-mediated signaling pathway,platelet degranulation,positive regulation of glomerular filtration,signal peptide processing,protein phosphorylation,ER to Golgi vesicle-mediated transport,phagocytosis,apoptotic process,cell cycle arrest,cell adhesion,signal transduction,enzyme linked receptor protein signaling pathway,cell proliferation,cellular response to starvation,positive regulation of gene expression,negative regulation of tumor necrosis factor-mediated signaling pathway,macrophage cytokine production,cell migration,peptidyl-serine phosphorylation,fusion of virus membrane with host plasma membrane,viral genome replication,platelet activation,animal organ regeneration,cell-substrate adhesion,positive regulation of TOR signaling,activation of protein kinase B activity,negative regulation of interferon-gamma production,negative regulation of interleukin-6 production,negative regulation of tumor necrosis factor production,positive regulation of natural killer cell differentiation,positive regulation of peptidyl-serine phosphorylation,negative regulation of protein import into nucleus, translocation,cellular response to interferon-alpha,cellular response to drug,B cell chemotaxis,regulation of growth,negative regulation of apoptotic process,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process,apoptotic cell clearance,negative regulation of sequence-specific DNA binding transcription factor activity,protein kinase B signaling,positive regulation of protein kinase activity,negative regulation of transcription, DNA-templated,viral entry into host cell,receptor-mediated virion attachment to host cell,positive regulation of protein export from nucleus,positive regulation of fibroblast proliferation,negative regulation of interleukin-1 secretion,positive regulation of phagocytosis,leukocyte migration,positive regulation of protein kinase B signaling,positive regulation of protein tyrosine kinase activity,negative regulation of biomineral tissue development,positive regulation of ERK1 and ERK2 cascade,platelet aggregation,calcium ion transmembrane transport,cellular response to vitamin K,cellular response to glucose stimulus,cellular response to growth factor stimulus,protein targeting to plasma membrane,extracellular matrix assembly,dendritic cell differentiation,hematopoietic stem cell migration to bone marrow,negative regulation of oligodendrocyte apoptotic process,negative regulation of interleukin-6 secretion,negative regulation of fibroblast apoptotic process,negative regulation of endothelial cell apoptotic process,positive regulation of dendritic cell chemotaxis,negative regulation of renal albumin absorption,negative regulation of dendritic cell apoptotic process;phosphatidylserine binding,receptor binding,voltage-gated calcium channel activity,calcium ion binding,protein binding,protein tyrosine kinase activator activity,receptor tyrosine kinase binding,cysteine-type endopeptidase inhibitor activity involved in apoptotic process,receptor agonist activity,binding, bridgingextracellular region,extracellular space,cytoplasm,endoplasmic reticulum lumen,Golgi lumen,platelet alpha granule lumen,extracellular exosome`>sp|Q14393|GAS6_HUMAN Growth arrest-specific protein 6 OS=Homo sapiens OX=9606 GN=GAS6 PE=1 SV=3Q7KZF4SND1 SND1_HUMAN3Staphylococcal nuclease domain-containing protein 1osteoblast differentiation,transcription, DNA-templated,regulation of transcription, DNA-templated,RNA catabolic process,viral process,gene silencing by RNA,nucleic acid phosphodiester bond hydrolysis^transcription cofactor activity,RNA binding,nuclease activity,protein binding,cadherin bindinginucleus,cytoplasm,mitochondrion,cytosol,membrane,RISC complex,melanosome,extracellular exosome,dense bodys>sp|Q7KZF4|SND1_HUMAN Staphylococcal nuclease domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SND1 PE=1 SV=1Q7L576CYFIP1 CYFP1_HUMAN&Cytoplasmic FMR1-interacting protein 1regulation of cell shape,Rac protein signal transduction,lamellipodium assembly,ruffle organization,cellular response to insulin stimulus,Fc-gamma receptor signaling pathway involved in phagocytosis,neutrophil degranulation,positive regulation of axon extension,vascular endothelial growth factor receptor signaling pathway,axon extension,cognition,positive regulation of neurotrophin TRK receptor signaling pathway,response to electrical stimulus,dendrite extension,positive regulation of dendrite development,positive regulation of ruffle assembly,negative regulation of synaptic vesicle recycling,positive regulation of Arp2/3 complex-mediated actin nucleationsRNA 7-methylguanosine cap binding,protein binding,protein complex binding,Rac GTPase binding,actin filament bindingruffle,extracellular region,cytosol,mRNA cap binding complex,focal adhesion,lamellipodium,SCAR complex,filopodium tip,secretory granule lumen,specific granule lumen,neuron projection,neuronal cell body,terminal bouton,dendritic spine,dendritic growth cone,axonal growth cone,perinuclear region of cytoplasm,excitatory synapse,extracellular exosome,Requires Ontology,tertiary granule lumeni>sp|Q7L576|CYFP1_HUMAN Cytoplasmic FMR1-interacting protein 1 OS=Homo sapiens OX=9606 GN=CYFIP1 PE=1 SV=1P34932HSPA4 HSP74_HUMANHeat shock 70 kDa protein 4yresponse to unfolded protein,protein import into mitochondrial outer membrane,chaperone-mediated protein complex assembly]>sp|P34932|HSP74_HUMAN Heat shock 70 kDa protein 4 OS=Homo sapiens OX=9606 GN=HSPA4 PE=1 SV=4Q6DD88ATL3 ATLA3_HUMAN Atlastin-3xendoplasmic reticulum organization,Golgi organization,protein homooligomerization,ER to Golgi vesicle-mediated transportEGTPase activity,protein binding,GTP binding,identical protein bindingendoplasmic reticulum,endoplasmic reticulum membrane,membrane,integral component of membrane,endoplasmic reticulum tubular networkK>sp|Q6DD88|ATLA3_HUMAN Atlastin-3 OS=Homo sapiens OX=9606 GN=ATL3 PE=1 SV=1P05997COL5A2 CO5A2_HUMANCollagen alpha-2(V) chainskeletal system development,ossification,extracellular matrix organization,collagen fibril organization,collagen catabolic process,skin development,eye morphogenesis,cellular response to amino acid stimulus,negative regulation of endodermal cell differentiation]molecular_function,extracellular matrix structural constituent,SMAD binding,metal ion bindingpextracellular region,collagen type V trimer,extracellular space,endoplasmic reticulum lumen,extracellular matrix\>sp|P05997|CO5A2_HUMAN Collagen alpha-2(V) chain OS=Homo sapiens OX=9606 GN=COL5A2 PE=1 SV=3O75083WDR1 WDR1_HUMANWD repeat-containing protein 1Sneutrophil mediated immunity,platelet degranulation,sensory perception of sound,regulation of cell shape,actin filament fragmentation,platelet formation,regulation of actin filament depolymerization,positive regulation of actin filament depolymerization,cortical cytoskeleton organization,locomotion,establishment of planar polarity of follicular epithelium,apical junction assembly,maintenance of epithelial cell apical/basal polarity,sarcomere organization,regulation of oligodendrocyte differentiation,regulation of ventricular cardiac muscle cell membrane repolarization,neutrophil migrationactin filament bindingpodosome,extracellular region,cytosol,cell-cell junction,cortical actin cytoskeleton,actomyosin, actin portion,cell projection,myelin sheath,extracellular exosome^>sp|O75083|WDR1_HUMAN WD < repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=WDR1 PE=1 SV=4P49591SARS1 SYSC_HUMAN Serine--tRNA ligase, cytoplasmictranslation,tRNA aminoacylation for protein translation,seryl-tRNA aminoacylation,tRNA processing,selenocysteine metabolic process,selenocysteinyl-tRNA(Sec) biosynthetic processWRNA binding,serine-tRNA ligase activity,ATP binding,selenocysteine-tRNA ligase activitya>sp|P49591|SYSC_HUMAN Serine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=SARS1 PE=1 SV=3Q14203DCTN1 DCTN1_HUMANDynactin subunit 1>G2/M transition of mitotic cell cycle,ER to Golgi vesicle-mediated transport,mitotic nuclear division,nervous system development,centriole-centriole cohesion,transport along microtubule,antigen processing and presentation of exogenous peptide antigen via MHC class II,positive regulation of microtubule polymerization,melanosome transport,microtubule anchoring at centrosome,IRE1-mediated unfolded protein response,retrograde transport, endosome to Golgi,nuclear envelope disassembly,positive regulation of microtubule nucleation,ciliary basal body docking,Requires OntologyYmotor activity,protein binding,microtubule binding,tubulin binding,dynein complex bindingkinetochore,spindle pole,nuclear envelope,cytoplasm,centrosome,centriole,spindle,cytosol,dynactin complex,microtubule,actin cytoskeleton,membrane,dynein complex,cell leading edge,microtubule plus-end,retromer complexT>sp|Q14203|DCTN1_HUMAN Dynactin subunit 1 OS=Homo sapiens OX=9606 GN=DCTN1 PE=1 SV=3P23396RPS3 RS3_HUMAN40S ribosomal protein S3nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,DNA repair,transcription, DNA-templated,regulation of transcription, DNA-templated,rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,apoptotic process,cellular response to DNA damage stimulus,response to oxidative stress,chromosome segregation,mitotic nuclear division,positive regulation of gene expression,negative regulation of translation,viral transcription,positive regulation of microtubule polymerization,negative regulation of protein ubiquitination,positive regulation of endodeoxyribonuclease activity,DNA damage response, detection of DNA damage,regulation of apoptotic process,positive regulation of JUN kinase activity,negative regulation of DNA repair,positive regulation of DNA repair,spindle assembly,cell division,response to TNF agonist,cellular response to hydrogen peroxide,positive regulation of NIK/NF-kappaB signaling,positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage,positive regulation of DNA N-glycosylase activity,positive regulation of base-excision repair,positive regulation of apoptotic signaling pathway,positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosisgDNA binding,damaged DNA binding,RNA binding,mRNA binding,structural constituent of ribosome,DNA-(apurinic or apyrimidinic site) lyase activity,endodeoxyribonuclease activity,protein binding,microtubule binding,transcription factor binding,tubulin binding,enzyme binding,kinase binding,protein kinase binding,Hsp70 protein binding,SUMO binding,oxidized purine DNA binding,oxidized pyrimidine DNA binding,ubiquitin-like protein conjugating enzyme binding,protein kinase A binding,iron-sulfur cluster binding,Hsp90 protein binding,small ribosomal subunit rRNA binding,supercoiled DNA binding,DNA N-glycosylase activityFnucleus,nucleoplasm,nucleolus,cytoplasm,mitochondrial inner membrane,mitochondrial matrix,endoplasmic reticulum,cytosol,ribosome,polysome,plasma membrane,focal adhesion,membrane,cytosolic small ribosomal subunit,intracellular ribonucleoprotein complex,extracellular matrix,ruffle membrane,extracellular exosome,mitotic spindleW>sp|P23396|RS3_HUMAN 40S ribosomal protein S3 OS=Homo sapiens OX=9606 GN=RPS3 PE=1 SV=2O00232PSMD12 PSD12_HUMAN/26S proteasome non-ATPase regulatory subunit 12proteasome complex,extracellular region,nucleoplasm,cytoplasm,cytosol,proteasome regulatory particle,proteasome regulatory particle, lid subcomplex,membrane,proteasome accessory complex,nuclear proteasome complex,secretory granule lumen,extracellular exosome,ficolin-1-rich granule lumenr>sp|O00232|PSD12_HUMAN 26S proteasome non-ATPase regulatory subunit 12 OS=Homo sapiens OX=9606 GN=PSMD12 PE=1 SV=3Q9UNM6PSMD13 PSD13_HUMAN/26S proteasome non-ATPase regulatory subunit 13MAPK cascade,protein polyubiquitination,stimulatory C-type lectin receptor signaling pathway,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent,ubiquitin-dependent protein catabolic process,regulation of cellular amino acid metabolic process,meiosis I,negative regulation of G2/M transition of mitotic cell cycle,protein deubiquitination,anaphase-promoting complex-dependent catabolic process,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process,tumor necrosis factor-mediated signaling pathway,NIK/NF-kappaB signaling,Fc-epsilon receptor signaling pathway,proteasome-mediated ubiquitin-dependent protein catabolic process,proteasome assembly,neutrophil degranulation,regulation of mRNA stability,T cell receptor signaling pathway,negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition,transmembrane transport,Wnt signaling pathway, planar cell polarity pathway,regulation of transcription from RNA polymerase II promoter in response to hypoxia,negative regulation of canonical Wnt signaling pathway,positive regulation of canonical Wnt signaling pathwaystructural molecule activityproteasome complex,extracellular region,nucleus,nucleoplasm,cytosol,proteasome regulatory particle,proteasome regulatory particle, lid subcomplex,membrane,proteasome accessory complex,secretory granule lumen,extracellular exosome,ficolin-1-rich granule lumenr>sp|Q9UNM6|PSD13_HUMAN 26S proteasome non-ATPase regulatory subunit 13 OS=Homo sapiens OX=9606 GN=PSMD13 PE=1 SV=2P43686PSMC4 PRS6B_HUMAN$26S proteasome regulatory subunit 6BMAPK cascade,protein polyubiquitination,blastocyst development,stimulatory C-type lectin receptor signaling pathway,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent,proteolysis,regulation of cellular amino acid metabolic process,negative regulation of G2/M transition of mitotic cell cycle,protein deubiquitination,ER-associated ubiquitin-dependent protein catabolic process,anaphase-promoting complex-dependent catabolic process,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process,tumor necrosis factor-mediated signaling pathway,NIK/NF-kappaB signaling,Fc-epsilon receptor signaling pathway,proteasome-mediated ubiquitin-dependent protein catabolic process,regulation of mRNA stability,positive regulation of RNA polymerase II transcriptional preinitiation complex assembly,T cell receptor signaling pathway,negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition,transmembrane transport,Wnt signaling pathway, planar cell polarity pathway,regulation of transcription from RNA polymerase II promoter in response to hypoxia,negative regulation of canonical Wnt signaling pathway,positive regulation of canonical Wnt signaling pathway,positive regulation of proteasomal protein catabolic processkprotein binding,ATP binding,ATPase activity,TBP-class protein binding,proteasome-activating ATPase activityproteasome complex,nucleus,nucleoplasm,cytosol,proteasome regulatory particle, base subcomplex,membrane,inclusion body,proteasome accessory complex,nuclear proteasome complex,cytosolic proteasome complex,synapsef>sp|P43686|PRS6B_HUMAN 26S proteasome regulatory subunit 6B OS=Homo sapiens OX=9606 GN=PSMC4 PE=1 SV=2Q9Y230RUVBL2 RUVB2_HUMAN RuvB-like 2DDNA repair,DNA recombination,chromatin remodeling,transcription, DNA-templated,protein < folding,DNA duplex unwinding,cellular response to UV,positive regulation of histone acetylation,regulation of growth,histone H4 acetylation,histone H2A acetylation,positive regulation of transcription from RNA polymerase II promoter,establishment of protein localization to chromatin,cellular response to estradiol stimulus,transcriptional activation by promoter-enhancer looping,negative regulation of estrogen receptor binding,positive regulation of telomerase RNA localization to Cajal bodyRNA polymerase II core promoter sequence-specific DNA binding,RNA polymerase II distal enhancer sequence-specific DNA binding,TFIID-class transcription factor binding,DNA helicase activity,ATP-dependent DNA helicase activity,protein binding,ATP binding,chromatin DNA binding,identical protein binding,protein homodimerization activity,ATP-dependent 5'-3' DNA helicase activity,ADP binding,unfolded protein binding,ATPase binding,ATPase activitySwr1 complex,intracellular,nucleus,nucleoplasm,nuclear euchromatin,centrosome,cytosol,membrane,nuclear matrix,intracellular ribonucleoprotein complex,Ino80 complex,NuA4 histone acetyltransferase complex,extracellular exosome,MLL1 complex,R2TP complexN>sp|Q9Y230|RUVB2_HUMAN RuvB-like 2 OS=Homo sapiens OX=9606 GN=RUVBL2 PE=1 SV=3P60174TPI1 TPIS_HUMANTriosephosphate isomerasegluconeogenesis,glycolytic process,pentose-phosphate shunt,multicellular organism development,glycerol catabolic process,glyceraldehyde-3-phosphate biosynthetic process,canonical glycolysisTtriose-phosphate isomerase activity,protein binding,ubiquitin protein ligase binding9extracellular space,nucleus,cytosol,extracellular exosomeY>sp|P60174|TPIS_HUMAN Triosephosphate isomerase OS=Homo sapiens OX=9606 GN=TPI1 PE=1 SV=4P20908COL5A1 CO5A1_HUMANCollagen alpha-1(V) chainblood vessel development,heart morphogenesis,cell adhesion,cell migration,extracellular matrix organization,collagen fibril organization,collagen catabolic process,collagen biosynthetic process,wound healing, spreading of epidermal cells,tendon development,skin development,integrin biosynthetic process,eye morphogenesis,regulation of cellular component organization,fibril organization,negative regulation of endodermal cell differentiationintegrin binding,extracellular matrix structural constituent,heparin binding,proteoglycan binding,metal ion binding,platelet-derived growth factor bindingextracellular region,collagen type V trimer,basement membrane,extracellular space,endoplasmic reticulum lumen,extracellular matrix,extracellular exosome\>sp|P20908|CO5A1_HUMAN Collagen alpha-1(V) chain OS=Homo sapiens OX=9606 GN=COL5A1 PE=1 SV=3Q14254FLOT2 FLOT2_HUMAN Flotillin-2membrane raft assembly,cell adhesion,epidermis development,negative regulation of gene expression,protein localization to plasma membrane raft,regulation of myoblast differentiation,protein stabilization,establishment of protein localization to plasma membrane,negative regulation of amyloid precursor protein catabolic process,positive regulation of establishment of T cell polarity,regulation of heterotypic cell-cell adhesion,regulation of toll-like receptor 3 signaling pathwayXuropod,acrosomal membrane,endosome,plasma membrane,caveola,cell-cell adherens junction,focal adhesion,membrane,basolateral plasma membrane,flotillin complex,lamellipodium,endocytic vesicle,cytoplasmic vesicle,vesicle,cell-cell contact zone,perinuclear region of cytoplasm,extracellular exosome,apical plasma membrane,cortical actin cytoskeletonM>sp|Q14254|FLOT2_HUMAN Flotillin-2 OS=Homo sapiens OX=9606 GN=FLOT2 PE=1 SV=2P27487DPP4 DPP4_HUMANDipeptidyl peptidase 4behavioral fear response,response to hypoxia,proteolysis,cell adhesion,positive regulation of cell proliferation,negative regulation of extracellular matrix disassembly,T cell costimulation,regulation of cell-cell adhesion mediated by integrin,locomotory exploration behavior,psychomotor behavior,T cell activation,endothelial cell migration,viral entry into host cell,regulation of insulin secretionvirus receptor activity,protease binding,serine-type endopeptidase activity,receptor binding,protein binding,serine-type peptidase activity,dipeptidyl-peptidase activity,identical protein binding,protein homodimerization activityextracellular region,lysosomal membrane,plasma membrane,focal adhesion,cell surface,membrane,integral component of membrane,apical plasma membrane,lamellipodium,endocytic vesicle,lamellipodium membrane,membrane raft,intercellular canaliculus,extracellular exosome,invadopodium membraneV>sp|P27487|DPP4_HUMAN Dipeptidyl peptidase 4 OS=Homo sapiens OX=9606 GN=DPP4 PE=1 SV=2P35052GPC1 GPC1_HUMAN Glypican-1retinoid metabolic process,glycosaminoglycan biosynthetic process,glycosaminoglycan catabolic process,axon guidance,Schwann cell differentiation,heparan sulfate proteoglycan catabolic process,glycosaminoglycan metabolic process,myelin assembly,negative regulation of fibroblast growth factor receptor signaling pathway,leukocyte migration,positive regulation of skeletal muscle cell differentiationhcopper ion binding,fibroblast growth factor binding,laminin binding,heparan sulfate proteoglycan bindingproteinaceous extracellular matrix,extracellular space,nucleoplasm,endosome,Golgi lumen,cytosol,plasma membrane,integral component of plasma membrane,anchored component of membrane,lysosomal lumen,membrane raft,extracellular exosomeJ>sp|P35052|GPC1_HUMAN Glypican-1 OS=Homo sapiens OX=9606 GN=GPC1 PE=1 SV=2O00469PLOD2 PLOD2_HUMAN1Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2Uresponse to hypoxia,cellular protein modification process,oxidation-reduction processRiron ion binding,procollagen-lysine 5-dioxygenase activity,L-ascorbic acid bindingoendoplasmic reticulum,endoplasmic reticulum membrane,rough endoplasmic reticulum membrane,extracellular exosomes>sp|O00469|PLOD2_HUMAN Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 OS=Homo sapiens OX=9606 GN=PLOD2 PE=1 SV=2Q13835PKP1 PKP1_HUMAN Plakophilin-1cell adhesion,signal transduction,single organismal cell-cell adhesion,keratinization,neutrophil degranulation,intermediate filament bundle assembly,cornificationzsignal transducer activity,protein binding,lamin binding,intermediate filament binding,structural constituent of epidermiscornified envelope,nucleus,nucleoplasm,intermediate filament,plasma membrane,desmosome,intracellular membrane-bounded organelle,extracellular exosome,ficolin-1-rich granule membraneM>sp|Q13835|PKP1_HUMAN Plakophilin-1 OS=Homo sapiens OX=9606 GN=PKP1 PE=1 SV=2Q86VP6CAND1 CAND1_HUMAN-Cullin-associated NEDD8-dissociated protein 1SCF complex assembly,protein ubiquitination,cell differentiation,negative regulation of catalytic activity,neutrophil degranulation,positive regulation of RNA polymerase II transcriptional preinitiation complex assembly)protein binding,TBP-class protein bindingubiquitin ligase complex,extracellular region,nucleus,nucleoplasm,cytoplasm,Golgi apparatus,cytosol,membrane,cullin-RING ubiquitin ligase complex,secretory granule lumen,extracellular exosome,ficolin-1-rich granule lumeno>sp|Q86VP6|CAND1_HUMAN Cullin-associated NEDD8-dissociated protein 1 OS=Homo sapiens OX=9606 GN=CAND1 PE=1 SV=2Q7Z7M9GALNT5 GALT5_HUMAN/Polypeptide N-acetylgalactosaminyltransferase 5:glycosaminoglycan biosynthetic process,O-glycan processing]polypeptide N-acetylgalactosaminyltransferase activity,carbohydrate binding,metal ion binding@Golgi membrane,cellular_component,integral component of membraner>sp|Q7Z7M9|GALT5_HUMAN Polypeptide N-acetylgalactosaminyltransferase 5 OS=Homo sapiens OX=9606 GN=GALNT5 PE=1 SV=1Q07065CKAP4 CKAP4_HUMAN!Cytoskeleton-associated protein 4;neutrophil degranulation,cellular protein metabolic processMcytoplasmic mRNA processing body,endoplasmic reticulum,endoplasmic reticulum membrane,lipid particle,cytosol,cytoskeleton,plasma membrane,membrane,integral component of membrane,nuclear speck,extracellular matrix,azurophil granule membrane,specific granule membrane,lamellar body,perinuclear region of cytoplasm,extracellular exosome< c>sp|Q07065|CKAP4_HUMAN Cytoskeleton-associated protein 4 OS=Homo sapiens OX=9606 GN=CKAP4 PE=1 SV=2Q6YHK3CD109 CD109_HUMAN CD109 antigennegative regulation of protein phosphorylation,hair follicle development,platelet degranulation,C-terminal protein lipidation,negative regulation of keratinocyte proliferation,negative regulation of endopeptidase activity,negative regulation of transforming growth factor beta receptor signaling pathway,regulation of keratinocyte differentiation,negative regulation of wound healing,osteoclast fusionTserine-type endopeptidase inhibitor activity,transforming growth factor beta bindingextracellular region,extracellular space,plasma membrane,cell surface,platelet alpha granule membrane,anchored component of membraneO>sp|Q6YHK3|CD109_HUMAN CD109 antigen OS=Homo sapiens OX=9606 GN=CD109 PE=1 SV=2O14672ADAM10 ADA10_HUMAN>Disintegrin and metalloproteinase domain-containing protein 10in utero embryonic development,protein phosphorylation,membrane protein ectodomain proteolysis,negative regulation of cell adhesion,Notch signaling pathway,Notch receptor processing,integrin-mediated signaling pathway,cell-cell signaling,positive regulation of cell proliferation,positive regulation of T cell chemotaxis,protein processing,extracellular matrix disassembly,positive regulation of cell growth,positive regulation of cell migration,response to tumor necrosis factor,monocyte activation,neutrophil degranulation,ephrin receptor signaling pathway,PMA-inducible membrane protein ectodomain proteolysis,constitutive protein ectodomain proteolysisendopeptidase activity,metalloendopeptidase activity,receptor binding,integrin binding,protein binding,metallopeptidase activity,SH3 domain binding,protein kinase binding,protein homodimerization activity,metal ion bindingSGolgi membrane,extracellular space,nucleus,cytoplasm,Golgi apparatus,Golgi-associated vesicle,plasma membrane,focal adhesion,cell surface,postsynaptic density,membrane,integral component of membrane,specific granule membrane,extracellular exosome,tertiary granule membrane,perinuclear endoplasmic reticulum,tetraspanin-enriched microdomain>sp|O14672|ADA10_HUMAN Disintegrin and metalloproteinase domain-containing protein 10 OS=Homo sapiens OX=9606 GN=ADAM10 PE=1 SV=1P36578RPL4 RL4_HUMAN60S ribosomal protein L4W>sp|P36578|RL4_HUMAN 60S ribosomal protein L4 OS=Homo sapiens OX=9606 GN=RPL4 PE=1 SV=5P62701RPS4X RS4X_HUMAN#40S ribosomal protein S4, X isoform8nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,multicellular organism development,positive regulation of cell proliferation,viral transcription,positive regulation of translationnucleoplasm,cytosol,ribosome,polysome,focal adhesion,small ribosomal subunit,membrane,cytosolic small ribosomal subunit,intracellular ribonucleoprotein complex,extracellular matrix,cytoplasmic ribonucleoprotein granule,extracellular exosomed>sp|P62701|RS4X_HUMAN 40S ribosomal protein S4, X isoform OS=Homo sapiens OX=9606 GN=RPS4X PE=1 SV=2P46821MAP1B MAP1B_HUMAN!Microtubule-associated protein 1Bmicrotubule bundle formation,cellular process,dendrite development,negative regulation of intracellular transport,positive regulation of axon extension,mitochondrion transport along microtubule,axon extension,establishment of monopolar cell polarityphotoreceptor outer segment,cytosol,microtubule,microtubule associated complex,plasma membrane,postsynaptic density,cell junction,dendritic spinec>sp|P46821|MAP1B_HUMAN Microtubule-associated protein 1B OS=Homo sapiens OX=9606 GN=MAP1B PE=1 SV=2Q92743HTRA1 HTRA1_HUMANSerine protease HTRA1zregulation of cell growth,placenta development,proteolysis,extracellular matrix disassembly,negative regulation of transforming growth factor beta receptor signaling pathway,negative regulation of BMP signaling pathway,positive regulation of epithelial cell proliferation,negative regulation of defense response to virus,chorionic trophoblast cell differentiation,dentinogenesisdserine-type endopeptidase activity,insulin-like growth factor binding,serine-type peptidase activitykextracellular region,extracellular space,cytosol,plasma membrane,extracellular matrix,extracellular exosomeW>sp|Q92743|HTRA1_HUMAN Serine protease HTRA1 OS=Homo sapiens OX=9606 GN=HTRA1 PE=1 SV=1Q9BUF5TUBB6 TBB6_HUMANTubulin beta-6 chainUmolecular_function,GTPase activity,structural constituent of cytoskeleton,GTP bindingLnucleus,cytoplasm,microtubule,microtubule cytoskeleton,extracellular exosomeU>sp|Q9BUF5|TBB6_HUMAN Tubulin beta-6 chain OS=Homo sapiens OX=9606 GN=TUBB6 PE=1 SV=1P39060COL18A1 COIA1_HUMANCollagen alpha-1(XVIII) chainangiogenesis,endothelial cell morphogenesis,cell adhesion,visual perception,positive regulation of cell proliferation,negative regulation of cell proliferation,animal organ morphogenesis,extracellular matrix organization,positive regulation of cell migration,collagen catabolic process,response to drug,response to hydrostatic pressure,positive regulation of endothelial cell apoptotic process.structural molecule activity,metal ion bindingextracellular region,collagen trimer,basement membrane,extracellular space,endoplasmic reticulum lumen,extracellular matrix,extracellular exosomea>sp|P39060|COIA1_HUMAN Collagen alpha-1(XVIII) chain OS=Homo sapiens OX=9606 GN=COL18A1 PE=1 SV=5P02786TFRC TFR1_HUMANTransferrin receptor protein 1cellular iron ion homeostasis,osteoclast differentiation,positive regulation of B cell proliferation,receptor internalization,transferrin transport,cellular response to drug,positive regulation of T cell proliferation,positive regulation of bone resorption,positive regulation of isotype switching,viral entry into host cell,membrane organization,iron ion import,regulation of cell growth,regulation of cell proliferationvirus receptor activity,glycoprotein binding,RNA binding,double-stranded RNA binding,transferrin receptor activity,protein binding,transferrin transmembrane transporter activity,identical protein binding,protein homodimerization activityextracellular region,extracellular space,endosome,plasma membrane,integral component of plasma membrane,clathrin-coated pit,external side of plasma membrane,cell surface,membrane,basolateral plasma membrane,clathrin-coated vesicle membrane,cytoplasmic vesicle,melanosome,perinuclear region of cytoplasm,recycling endosome,extracellular exosome,blood microparticle,extracellular vesicle,HFE-transferrin receptor complex^>sp|P02786|TFR1_HUMAN Transferrin receptor protein 1 OS=Homo sapiens OX=9606 GN=TFRC PE=1 SV=2P08779KRT16 K1C16_HUMANKeratin, type I cytoskeletal 16dmorphogenesis of an epithelium,inflammatory response,cytoskeleton organization,aging,cell proliferation,epidermis development,keratinocyte differentiation,negative regulation of cell migration,keratinization,hair cycle,innate immune response,intermediate filament cytoskeleton organization,keratinocyte migration,establishment of skin barrier,cornificationHnucleus,cytosol,cytoskeleton,intermediate filament,extracellular exosomea>sp|P08779|K1C16_HUMAN Keratin, type I cytoskeletal 16 OS=Homo sapiens OX=9606 GN=KRT16 PE=1 SV=4P04899GNAI2 GNAI2_HUMAN7Guanine nucleotide-binding protein G(i) subunit alpha-2Qactivation of MAPKK activity,adenosine receptor signaling pathway,protein folding,cell cycle,signal transduction,G-protein coupled receptor signaling pathway,adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway,negative regulation of adenylate cyclase activity,G-protein coupled acetylcholine receptor signaling pathway,gamma-aminobutyric acid signaling pathway,response to nutrient,cell proliferation,positive regulation of cell proliferation,intracellular signal transduction,negative regulation of synaptic transmission,cell division,regulation of calcium ion transportG-protein coupled receptor binding,GTPase activity,signal transducer activity,protein binding,GTP binding,G-protein beta/gamma-subuni< t complex binding,metal ion bindingnucleoplasm,cytoplasm,centrosome,cytosol,heterotrimeric G-protein complex,plasma membrane,membrane,dendrite,midbody,cell body,membrane raft,extracellular exosome,extracellular vesicley>sp|P04899|GNAI2_HUMAN Guanine nucleotide-binding protein G(i) subunit alpha-2 OS=Homo sapiens OX=9606 GN=GNAI2 PE=1 SV=3P50995ANXA11 ANX11_HUMAN Annexin A11=phagocytosis,cell cycle,cell division,response to calcium ionRNA binding,calcium ion binding,protein binding,calcium-dependent phospholipid binding,phosphatidylethanolamine binding,MHC class II protein complex binding,S100 protein binding,calcium-dependent protein bindingnuclear envelope,nucleoplasm,cytoplasm,spindle,cytosol,membrane,midbody,melanosome,specific granule,azurophil granule,phagocytic vesicle,extracellular exosomeN>sp|P50995|ANX11_HUMAN Annexin A11 OS=Homo sapiens OX=9606 GN=ANXA11 PE=1 SV=1P61158ACTR3 ARP3_HUMANActin-related protein 3}movement of cell or subcellular component,establishment or maintenance of cell polarity,asymmetric cell division,meiotic chromosome movement towards spindle pole,meiotic cytokinesis,Arp2/3 complex-mediated actin nucleation,Fc-gamma receptor signaling pathway involved in phagocytosis,ephrin receptor signaling pathway,spindle localization,cilium morphogenesis,membrane organizationYstructural constituent of cytoskeleton,protein binding,ATP binding,actin filament bindingcytosol,Arp2/3 protein complex,brush border,cell-cell junction,focal adhesion,actin cytoskeleton,membrane,lamellipodium,extracellular exosomeX>sp|P61158|ARP3_HUMAN Actin-related protein 3 OS=Homo sapiens OX=9606 GN=ACTR3 PE=1 SV=3P23229ITGA6 ITA6_HUMANIntegrin alpha-6cell-substrate junction assembly,cell-matrix adhesion,integrin-mediated signaling pathway,ectodermal cell differentiation,positive regulation of cell-substrate adhesion,single organismal cell-cell adhesion,positive regulation of cell-cell adhesion,extracellular matrix organization,positive regulation of cell migration,hemidesmosome assembly,cell-substrate adhesion,cellular response to extracellular stimulus,cell adhesion mediated by integrin,nail development,positive regulation of phosphorylation,positive regulation of apoptotic process,positive regulation of GTPase activity,skin development,positive regulation of transcription from RNA polymerase II promoter,filopodium assembly,digestive tract development,brown fat cell differentiation,leukocyte migration,cellular response to organic cyclic compound,renal system development,amelogenesis,negative regulation of extrinsic apoptotic signaling pathwayintegrin binding,protein binding,laminin binding,cadherin binding,metal ion binding,insulin-like growth factor I binding,neuregulin bindingbasement membrane,plasma membrane,cell-cell adherens junction,focal adhesion,external side of plasma membrane,basal plasma membrane,cell surface,hemidesmosome,filopodium,integrin alpha6-beta4 complexQ>sp|P23229|ITA6_HUMAN Integrin alpha-6 OS=Homo sapiens OX=9606 GN=ITGA6 PE=1 SV=5Q9Y262EIF3L EIF3L_HUMAN4Eukaryotic translation initiation factor 3 subunit LEtranslational initiation,viral translational termination-reinitiationBRNA binding,protein binding,translation initiation factor activity`fibrillar center,nucleoplasm,cytosol,eukaryotic translation initiation factor 3 complex,membranev>sp|Q9Y262|EIF3L_HUMAN Eukaryotic translation initiation factor 3 subunit L OS=Homo sapiens OX=9606 GN=EIF3L PE=1 SV=1P40227CCT6A TCPZ_HUMAN T-complex protein 1 subunit zetaaprotein folding,'de novo' protein folding,positive regulation of telomere maintenance via telomerase,protein stabilization,chaperone-mediated protein folding,positive regulation of establishment of protein localization to telomere,positive regulation of protein localization to Cajal body,positive regulation of telomerase RNA localization to Cajal bodyRNA binding,protein binding,ATP binding,protein binding involved in protein folding,unfolded protein binding,WD40-repeat domain bindinghcytoplasm,cytosol,chaperonin-containing T-complex,microtubule,extracellular matrix,extracellular exosomea>sp|P40227|TCPZ_HUMAN T-complex protein 1 subunit zeta OS=Homo sapiens OX=9606 GN=CCT6A PE=1 SV=3Q9UKU9ANGPTL2 ANGL2_HUMANAngiopoietin-related protein 2"multicellular organism developmentreceptor binding)extracellular space,extracellular exosomeb>sp|Q9UKU9|ANGL2_HUMAN Angiopoietin-related protein 2 OS=Homo sapiens OX=9606 GN=ANGPTL2 PE=1 SV=1P54136RARS1 SYRC_HUMAN"Arginine--tRNA ligase, cytoplasmicGtRNA aminoacylation for protein translation,arginyl-tRNA aminoacylationhtRNA binding,arginine-tRNA ligase activity,protein binding,ATP binding,arginine binding,cadherin bindingxnucleoplasm,cytoplasm,mitochondrion,cytosol,membrane,aminoacyl-tRNA synthetase multienzyme complex,extracellular exosomec>sp|P54136|SYRC_HUMAN Arginine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=RARS1 PE=1 SV=2Q9Y678COPG1 COPG1_HUMANCoatomer subunit gamma-1intracellular protein transport,ER to Golgi vesicle-mediated transport,retrograde vesicle-mediated transport, Golgi to ER,establishment of Golgi localization,organelle transport along microtubuleiGolgi membrane,endoplasmic reticulum membrane,Golgi apparatus,cytosol,COPI vesicle coat,transport vesicleZ>sp|Q9Y678|COPG1_HUMAN Coatomer subunit gamma-1 OS=Homo sapiens OX=9606 GN=COPG1 PE=1 SV=1P07585DCN PGS2_HUMANDecorinkidney development,placenta development,negative regulation of protein kinase activity,skeletal muscle tissue development,aging,response to mechanical stimulus,animal organ morphogenesis,positive regulation of autophagy,negative regulation of endothelial cell migration,positive regulation of phosphatidylinositol 3-kinase signaling,positive regulation of macroautophagy,negative regulation of angiogenesis,cytokine-mediated signaling pathway,peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan,extracellular matrix disassembly,extracellular matrix organization,glycosaminoglycan metabolic process,chondroitin sulfate biosynthetic process,chondroitin sulfate catabolic process,dermatan sulfate biosynthetic process,response to lipopolysaccharide,wound healing,positive regulation of transcription from RNA polymerase II promoter,negative regulation of JAK-STAT cascade,positive regulation of mitochondrial depolarization,positive regulation of mitochondrial fission,negative regulation of vascular endothelial growth factor signaling pathwayRNA binding,protein kinase inhibitor activity,protein binding,collagen binding,glycosaminoglycan binding,protein N-terminus binding,extracellular matrix bindingextracellular region,proteinaceous extracellular matrix,collagen type VI trimer,extracellular space,cytoplasm,Golgi lumen,lysosomal lumen,extracellular matrixF>sp|P07585|PGS2_HUMAN Decorin OS=Homo sapiens OX=9606 GN=DCN PE=1 SV=1P09871C1S C1S_HUMANComplement C1s subcomponentpcomplement activation, lectin pathway,proteolysis,complement activation,complement activation, classical pathway`serine-type endopeptidase activity,calcium ion binding,protein binding,identical protein bindingY>sp|P09871|C1S_HUMAN Complement C1s subcomponent OS=Homo sapiens OX=9606 GN=C1S PE=1 SV=1Q14697GANAB GANAB_HUMANNeutral alpha-glucosidase AB.carbohydrate metabolic process,protein foldingFRNA binding,carbohydrate binding,glucan 1,3-alpha-glucosidase activityendoplasmic reticulum lumen,Golgi apparatus,membrane,glucosidase II complex,extracellular matrix,melanosome,extracellular exosome^>sp|Q14697|GANAB_HUMAN Neutral alpha-glucosidase AB OS=Homo sapiens OX=9606 GN=GANAB PE=1 SV=3P05556ITGB1 ITB1_HUMANIntegrin beta-1G1/S transition of mitotic cell cycle,in utero embryonic development,cell fate specification,cell migration involved in sprouting angiogenesis,cellular defense response,homophilic cell adhesion via plasma membrane adhesion molecules,leukocyte cell-cell adhesion,cell-matrix adhesion,calcium-independent cell-matrix adhesion,integrin-mediated signaling pathway,positive regulation of cell proliferation,germ cell migration,vis< ual learning,regulation of collagen catabolic process,cell migration,formation of radial glial scaffolds,B cell differentiation,extracellular matrix organization,cell-substrate adhesion,receptor internalization,cell adhesion mediated by integrin,cell-cell adhesion mediated by integrin,heterotypic cell-cell adhesion,negative regulation of Rho protein signal transduction,positive regulation of apoptotic process,positive regulation of GTPase activity,sarcomere organization,negative regulation of cell differentiation,viral entry into host cell,mesodermal cell differentiation,axon extension,dendrite morphogenesis,regulation of immune response,leukocyte migration,leukocyte tethering or rolling,regulation of cell cycle,cardiac muscle cell differentiation,cellular response to low-density lipoprotein particle stimulus,positive regulation of establishment of protein localization to plasma membrane,negative regulation of anoikis,transforming growth factor beta receptor signaling pathway,stress fiber assemblyXvirus receptor activity,fibronectin binding,protease binding,actin binding,integrin binding,protein binding,coreceptor activity,protein complex binding,laminin binding,cadherin binding,metal ion binding,protein heterodimerization activity,cell adhesion molecule binding,collagen binding involved in cell-matrix adhesion,C-X3-C chemokine bindingruffle,cytoplasm,plasma membrane,focal adhesion,integrin complex,external side of plasma membrane,cell surface,intercalated disc,membrane,lamellipodium,filopodium,neuromuscular junction,cleavage furrow,ruffle membrane,integrin alpha1-beta1 complex,integrin alpha2-beta1 complex,integrin alpha3-beta1 complex,integrin alpha7-beta1 complex,integrin alpha8-beta1 complex,integrin alpha10-beta1 complex,integrin alpha11-beta1 complex,myelin sheath abaxonal region,sarcolemma,melanosome,dendritic spine,receptor complex,membrane raft,perinuclear region of cytoplasm,recycling endosome,extracellular exosome,invadopodium membrane,synaptic membraneP>sp|P05556|ITB1_HUMAN Integrin beta-1 OS=Homo sapiens OX=9606 GN=ITGB1 PE=1 SV=2P04406GAPDH G3P_HUMAN(Glyceraldehyde-3-phosphate dehydrogenasemicrotubule cytoskeleton organization,gluconeogenesis,regulation of macroautophagy,negative regulation of translation,peptidyl-cysteine S-trans-nitrosylation,protein stabilization,neuron apoptotic process,canonical glycolysis,cellular response to interferon-gammaglyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity,protein binding,microtubule binding,peptidyl-cysteine S-nitrosylase activity,identical protein binding,NADP binding,NAD bindingnucleus,cytoplasm,lipid particle,cytosol,plasma membrane,microtubule cytoskeleton,membrane,intracellular ribonucleoprotein complex,extracellular matrix,nuclear membrane,vesicle,intracellular membrane-bounded organelle,perinuclear region of cytoplasm,extracellular exosome,GAIT complexh>sp|P04406|G3P_HUMAN Glyceraldehyde-3-phosphate dehydrogenase OS=Homo sapiens OX=9606 GN=GAPDH PE=1 SV=3P06733ENO1 ENOA_HUMAN Alpha-enolasegluconeogenesis,transcription, DNA-templated,response to virus,negative regulation of cell growth,negative regulation of transcription, DNA-templated,canonical glycolysismagnesium ion binding,DNA binding,RNA binding,phosphopyruvate hydratase activity,protein binding,cadherin binding,GTPase bindingphosphopyruvate hydratase complex,extracellular space,nucleus,cytoplasm,cytosol,plasma membrane,membrane,M band,extracellular exosomeM>sp|P06733|ENOA_HUMAN Alpha-enolase OS=Homo sapiens OX=9606 GN=ENO1 PE=1 SV=2Q15008PSMD6 PSMD6_HUMAN.26S proteasome non-ATPase regulatory subunit 6MAPK cascade,protein polyubiquitination,stimulatory C-type lectin receptor signaling pathway,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent,proteolysis,regulation of cellular amino acid metabolic process,negative regulation of G2/M transition of mitotic cell cycle,protein deubiquitination,anaphase-promoting complex-dependent catabolic process,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process,tumor necrosis factor-mediated signaling pathway,NIK/NF-kappaB signaling,Fc-epsilon receptor signaling pathway,proteasome-mediated ubiquitin-dependent protein catabolic process,neutrophil degranulation,regulation of mRNA stability,T cell receptor signaling pathway,negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition,transmembrane transport,Wnt signaling pathway, planar cell polarity pathway,regulation of transcription from RNA polymerase II promoter in response to hypoxia,negative regulation of canonical Wnt signaling pathway,positive regulation of canonical Wnt signaling pathwayprotein binding,ATPase activityproteasome complex,extracellular region,nucleoplasm,cytosol,proteasome regulatory particle,proteasome accessory complex,secretory granule lumen,extracellular exosome,ficolin-1-rich granule lumenp>sp|Q15008|PSMD6_HUMAN 26S proteasome non-ATPase regulatory subunit 6 OS=Homo sapiens OX=9606 GN=PSMD6 PE=1 SV=1P07814EPRS1 SYEP_HUMAN+Bifunctional glutamate/proline--tRNA ligasetRNA aminoacylation for protein translation,glutamyl-tRNA aminoacylation,prolyl-tRNA aminoacylation,protein complex assembly,negative regulation of translation,cellular response to interferon-gamma|glutamate-tRNA ligase activity,proline-tRNA ligase activity,protein binding,ATP binding,RNA stem-loop binding,GTPase binding}cytoplasm,cytosol,membrane,aminoacyl-tRNA synthetase multienzyme complex,intracellular ribonucleoprotein complex,GAIT complexl>sp|P07814|SYEP_HUMAN Bifunctional glutamate/proline--tRNA ligase OS=Homo sapiens OX=9606 GN=EPRS1 PE=1 SV=5P31939ATIC PUR9_HUMAN-Bifunctional purine biosynthesis protein ATICrbrainstem development,nucleobase-containing compound metabolic process,'de novo' IMP biosynthetic process,nucleoside metabolic process,purine ribonucleoside monophosphate biosynthetic process,response to inorganic substance,cerebellum development,cerebral cortex development,animal organ regeneration,dihydrofolate metabolic process,tetrahydrofolate biosynthetic processIMP cyclohydrolase activity,phosphoribosylaminoimidazolecarboxamide formyltransferase activity,protein homodimerization activity,cadherin binding4mitochondrion,cytosol,membrane,extracellular exosomem>sp|P31939|PUR9_HUMAN Bifunctional purine biosynthesis protein ATIC OS=Homo sapiens OX=9606 GN=ATIC PE=1 SV=3Q9P2J5LARS1 SYLC_HUMAN!Leucine--tRNA ligase, cytoplasmictRNA aminoacylation for protein translation,leucyl-tRNA aminoacylation,valyl-tRNA aminoacylation,regulation of translational fidelitytaminoacyl-tRNA editing activity,leucine-tRNA ligase activity,valine-tRNA ligase activity,protein binding,ATP bindingcytosol,nuclear bodyb>sp|Q9P2J5|SYLC_HUMAN Leucine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=LARS1 PE=1 SV=2P63244RACK1 RACK1_HUMAN(Receptor of activated protein C kinase 1nosteoblast differentiation,positive regulation of protein phosphorylation,translation,apoptotic process,activation of cysteine-type endopeptidase activity involved in apoptotic process,cell cycle,gastrulation,negative regulation of gene expression,regulation of tumor necrosis factor-mediated signaling pathway,viral process,negative regulation of translation,negative regulation of Wnt signaling pathway,negative regulation of cell growth,positive regulation of cell migration,positive regulation of cAMP catabolic process,positive regulation of proteasomal ubiquitin-dependent protein catabolic process,positive regulation of protein homooligomerization,regulation of protein localization,negative regulation of peptidyl-serine phosphorylation,positive regulation of Golgi to plasma membrane protein transport,positive regulation of apoptotic process,pigmentation,positive regulation of GTPase activity,rhythmic process,negative regulation of phagocytosis,regulation of cell division,positive regulation of cyclic-nucleotide phosphodiesterase activity,regulation of cell cycl< e,negative regulation of protein kinase B signaling,positive regulation of mitochondrial depolarization,negative regulation of protein tyrosine kinase activity,cellular response to glucose stimulus,cellular response to growth factor stimulus,negative regulation of endoplasmic reticulum unfolded protein response,negative regulation of hydrogen peroxide-induced neuron death,regulation of establishment of cell polarity,positive regulation of ceramide biosynthetic process,positive regulation of gastrulation,positive regulation of intrinsic apoptotic signaling pathwayRNA binding,protein kinase C binding,receptor binding,protein binding,ion channel inhibitor activity,cysteine-type endopeptidase activator activity involved in apoptotic process,enzyme binding,protein phosphatase binding,protein tyrosine kinase inhibitor activity,receptor tyrosine kinase binding,protein complex scaffold,signaling adaptor activity,SH2 domain binding,protein homodimerization activity,cadherin bindingphagocytic cup,nucleus,nucleoplasm,cytoplasm,mitochondrion,cytosol,small ribosomal subunit,dendrite,midbody,neuronal cell body,perikaryon,perinuclear region of cytoplasm,extracellular exosome,IRE1-RACK1-PP2A complexj>sp|P63244|RACK1_HUMAN Receptor of activated protein C kinase 1 OS=Homo sapiens OX=9606 GN=RACK1 PE=1 SV=3P26022PTX3 PTX3_HUMANPentraxin-related protein PTX3response to yeast,inflammatory response,opsonization,neutrophil degranulation,negative regulation by host of viral exo-alpha-sialidase activity,negative regulation by host of viral glycoprotein metabolic process,innate immune response,positive regulation of nitric oxide biosynthetic process,negative regulation of viral entry into host cell,positive regulation of phagocytosis,negative regulation of exo-alpha-sialidase activity,negative regulation of glycoprotein metabolic processvcomplement component C1q binding,(1->3)-beta-D-glucan binding,protein binding,identical protein binding,virion bindingVextracellular region,extracellular space,specific granule lumen,tertiary granule lumen^>sp|P26022|PTX3_HUMAN Pentraxin-related protein PTX3 OS=Homo sapiens OX=9606 GN=PTX3 PE=1 SV=3P11717IGF2R MPRI_HUMAN/Cation-independent mannose-6-phosphate receptor]liver development,receptor-mediated endocytosis,signal transduction,G-protein coupled receptor signaling pathway,spermatogenesis,post-embryonic development,animal organ regeneration,response to retinoic acid,positive regulation of apoptotic process,neutrophil degranulation,insulin-like growth factor receptor signaling pathway,membrane organizationRglycoprotein binding,G-protein alpha-subunit binding,retinoic acid binding,receptor activity,G-protein coupled receptor activity,insulin-like growth factor-activated receptor activity,transporter activity,protein binding,mannose binding,enzyme binding,insulin-like growth factor II binding,identical protein binding,phosphoprotein bindingextracellular space,nuclear envelope lumen,lysosomal membrane,endosome,early endosome,late endosome,Golgi apparatus,trans-Golgi network,plasma membrane,integral component of plasma membrane,focal adhesion,cell surface,membrane,clathrin coat,transport vesicle,endocytic vesicle,trans-Golgi network transport vesicle,clathrin-coated vesicle membrane,secretory granule membrane,trans-Golgi network membrane,perinuclear region of cytoplasm,extracellular exosomep>sp|P11717|MPRI_HUMAN Cation-independent mannose-6-phosphate receptor OS=Homo sapiens OX=9606 GN=IGF2R PE=1 SV=3P50395GDI2 GDIB_HUMAN#Rab GDP dissociation inhibitor betasignal transduction,small GTPase mediated signal transduction,protein transport,neutrophil degranulation,positive regulation of GTPase activity,regulation of small GTPase mediated signal transduction,oxidation-reduction process,membrane organizationRNA binding,Rab GDP-dissociation inhibitor activity,GTPase activator activity,protein binding,oxidoreductase activity,small GTPase bindingextracellular region,cytoplasm,Golgi apparatus,cytosol,focal adhesion,membrane,vesicle,secretory granule lumen,azurophil granule lumen,myelin sheath,extracellular exosomec>sp|P50395|GDIB_HUMAN Rab GDP dissociation inhibitor beta OS=Homo sapiens OX=9606 GN=GDI2 PE=1 SV=2P30101PDIA3 PDIA3_HUMANProtein disulfide-isomerase A3antigen processing and presentation of peptide antigen via MHC class I,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent,protein folding,proteolysis,protein import into nucleus,protein retention in ER lumen,signal transduction,protein folding in endoplasmic reticulum,response to endoplasmic reticulum stress,cell redox homeostasis,oxidation-reduction process,positive regulation of extrinsic apoptotic signaling pathwayRNA binding,protein disulfide isomerase activity,cysteine-type endopeptidase activity,phospholipase C activity,protein binding,disulfide oxidoreductase activitynucleus,endoplasmic reticulum,endoplasmic reticulum lumen,focal adhesion,cell surface,melanosome,myelin sheath,phagocytic vesicle,recycling endosome membrane,extracellular exosome`>sp|P30101|PDIA3_HUMAN Protein disulfide-isomerase A3 OS=Homo sapiens OX=9606 GN=PDIA3 PE=1 SV=4P50454SERPINH1 SERPH_HUMAN Serpin H1chondrocyte development involved in endochondral bone morphogenesis,response to unfolded protein,negative regulation of endopeptidase activity,collagen fibril organization,collagen biosynthetic process,protein maturationbRNA binding,serine-type endopeptidase inhibitor activity,collagen binding,unfolded protein bindingendoplasmic reticulum,endoplasmic reticulum lumen,endoplasmic reticulum-Golgi intermediate compartment,membrane raft,extracellular exosome,extracellular spaceN>sp|P50454|SERPH_HUMAN Serpin H1 OS=Homo sapiens OX=9606 GN=SERPINH1 PE=1 SV=2P14923JUP PLAK_HUMANJunction plakoglobinJdesmosome assembly,cytoskeletal anchoring at plasma membrane,signal transduction,single organismal cell-cell adhesion,cell migration,keratinization,adherens junction organization,adherens junction assembly,regulation of cell proliferation,positive regulation of protein import into nucleus,neutrophil degranulation,detection of mechanical stimulus,positive regulation of sequence-specific DNA binding transcription factor activity,protein heterooligomerization,cornification,endothelial cell-cell adhesion,cellular response to indole-3-methanol,bundle of His cell-Purkinje myocyte adhesion involved in cell communication,regulation of heart rate by cardiac conduction,establishment of protein localization to plasma membrane,positive regulation of canonical Wnt signaling pathway,regulation of ventricular cardiac muscle cell action potentialtranscription coactivator activity,signal transducer activity,structural molecule activity,structural constituent of cell wall,protein binding,protein kinase binding,protein phosphatase binding,protein homodimerization activity,alpha-catenin binding,cadherin binding,cell adhesion molecule binding,cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communicationcornified envelope,extracellular region,nucleus,cytoplasm,cytosol,cytoskeleton,intermediate filament,plasma membrane,cell-cell junction,cell-cell adherens junction,zonula adherens,fascia adherens,focal adhesion,cytoplasmic side of plasma membrane,intercalated disc,actin cytoskeleton,apicolateral plasma membrane,lateral plasma membrane,catenin complex,Z disc,desmosome,extracellular matrix,protein-DNA complex,specific granule lumen,extracellular exosome,gamma-catenin-TCF7L2 complex,ficolin-1-rich granule lumen,hemidesmosomeS>sp|P14923|PLAK_HUMAN Junction plakoglobin OS=Homo sapiens OX=9606 GN=JUP PE=1 SV=3Q01518CAP1 CAP1_HUMAN%Adenylyl cyclase-associated protein 1cell morphogenesis,ameboidal-type cell migration,receptor-mediated endocytosis,establishment or maintenance of cell polarity,signal transduction,activation of adenylate cyclase activity,actin polymerization or depolymerization,neutrophil degranulation'actin binding,adenylate cyclase bindingextracellular region,extracellular space,plasma membrane,focal adhesion,cortical actin cytoskeleton,azuroph< il granule lumen,extracellular exosomee>sp|Q01518|CAP1_HUMAN Adenylyl cyclase-associated protein 1 OS=Homo sapiens OX=9606 GN=CAP1 PE=1 SV=5P08758ANXA5 ANXA5_HUMAN Annexin A5platelet degranulation,signal transduction,blood coagulation,response to organic substance,negative regulation of apoptotic process,negative regulation of catalytic activity,negative regulation of coagulationphospholipase inhibitor activity,calcium ion binding,protein binding,phospholipid binding,calcium-dependent phospholipid bindingextracellular region,intracellular,cytoplasm,cytosol,focal adhesion,external side of plasma membrane,membrane,extracellular exosome,endothelial microparticleL>sp|P08758|ANXA5_HUMAN Annexin A5 OS=Homo sapiens OX=9606 GN=ANXA5 PE=1 SV=2P00558PGK1 PGK1_HUMANPhosphoglycerate kinase 1Tgluconeogenesis,phosphorylation,epithelial cell differentiation,canonical glycolysis<phosphoglycerate kinase activity,protein binding,ATP binding4cytosol,membrane,membrane raft,extracellular exosomeY>sp|P00558|PGK1_HUMAN Phosphoglycerate kinase 1 OS=Homo sapiens OX=9606 GN=PGK1 PE=1 SV=3P17858PFKL PFKAL_HUMAN/ATP-dependent 6-phosphofructokinase, liver typefructose 6-phosphate metabolic process,glycolytic process,response to glucose,fructose 1,6-bisphosphate metabolic process,neutrophil degranulation,negative regulation of insulin secretion,protein oligomerization,protein homotetramerization,canonical glycolysis6-phosphofructokinase activity,protein binding,ATP binding,kinase binding,identical protein binding,metal ion binding,fructose binding,fructose-6-phosphate bindingextracellular region,cytosol,6-phosphofructokinase complex,membrane,secretory granule lumen,extracellular exosome,ficolin-1-rich granule lumenp>sp|P17858|PFKAL_HUMAN ATP-dependent 6-phosphofructokinase, liver type OS=Homo sapiens OX=9606 GN=PFKL PE=1 SV=6O43242PSMD3 PSMD3_HUMAN.26S proteasome non-ATPase regulatory subunit 3MAPK cascade,protein polyubiquitination,stimulatory C-type lectin receptor signaling pathway,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent,ubiquitin-dependent protein catabolic process,regulation of cellular amino acid metabolic process,negative regulation of G2/M transition of mitotic cell cycle,protein deubiquitination,anaphase-promoting complex-dependent catabolic process,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process,tumor necrosis factor-mediated signaling pathway,NIK/NF-kappaB signaling,Fc-epsilon receptor signaling pathway,proteasome-mediated ubiquitin-dependent protein catabolic process,neutrophil degranulation,regulation of mRNA stability,T cell receptor signaling pathway,negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition,transmembrane transport,Wnt signaling pathway, planar cell polarity pathway,regulation of transcription from RNA polymerase II promoter in response to hypoxia,negative regulation of canonical Wnt signaling pathway,positive regulation of canonical Wnt signaling pathway)protein binding,enzyme regulator activityproteasome complex,extracellular region,nucleus,nucleoplasm,cytosol,proteasome regulatory particle, lid subcomplex,membrane,proteasome accessory complex,secretory granule lumen,extracellular exosome,ficolin-1-rich granule lumenp>sp|O43242|PSMD3_HUMAN 26S proteasome non-ATPase regulatory subunit 3 OS=Homo sapiens OX=9606 GN=PSMD3 PE=1 SV=2P39059COL15A1 COFA1_HUMANCollagen alpha-1(XV) chain^angiogenesis,cell adhesion,signal transduction,cell differentiation,collagen catabolic process+extracellular matrix structural constituentextracellular region,collagen type XV trimer,extracellular space,endoplasmic reticulum lumen,integral component of membrane,extracellular exosome,extracellular matrix^>sp|P39059|COFA1_HUMAN Collagen alpha-1(XV) chain OS=Homo sapiens OX=9606 GN=COL15A1 PE=1 SV=2Q14152EIF3A EIF3A_HUMAN4Eukaryotic translation initiation factor 3 subunit Aformation of cytoplasmic translation initiation complex,translation reinitiation,translational initiation,negative regulation of ERK1 and ERK2 cascade,IRES-dependent viral translational initiation,viral translational termination-reinitiationRNA binding,mRNA binding,structural molecule activity,protein binding,receptor tyrosine kinase binding,translation initiation factor activitynucleus,nucleolus,cytoplasm,cytosol,eukaryotic translation initiation factor 3 complex,microtubule,membrane,multi-eIF complex,eukaryotic translation initiation factor 3 complex, eIF3e,eukaryotic translation initiation factor 3 complex, eIF3mv>sp|Q14152|EIF3A_HUMAN Eukaryotic translation initiation factor 3 subunit A OS=Homo sapiens OX=9606 GN=EIF3A PE=1 SV=1 P68104;Q5VTE0EEF1A1;EEF1A1P5EF1A1_HUMAN;EF1A3_HUMANEElongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3transcription, DNA-templated,regulation of transcription, DNA-templated,translational elongation,protein methylation,neutrophil degranulation,cellular response to epidermal growth factor stimulus,regulation of chaperone-mediated autophagy;translational elongation,biological_processtRNA binding,RNA binding,translation elongation factor activity,GTPase activity,protein binding,GTP binding,protein kinase binding;molecular_function,translation elongation factor activity,GTPase activity,GTP bindingpextracellular region,extracellular space,nucleus,nucleolus,cytoplasm,cytosol,eukaryotic translation elongation factor 1 complex,membrane,cortical actin cytoskeleton,ruffle membrane,secretory granule lumen,myelin sheath,extracellular exosome,cytoplasmic side of lysosomal membrane,ficolin-1-rich granule lumen;extracellular space,nucleus,cytoplasm,extracellular exosome1;5>sp|P68104|EF1A1_HUMAN Elongation factor 1-alpha 1 OS=Homo sapiens OX=9606 GN=EEF1A1 PE=1 SV=1;>sp|Q5VTE0|EF1A3_HUMAN Putative elongation factor 1-alpha-like 3 OS=Homo sapiens OX=9606 GN=EEF1A1P5 PE=5 SV=1P62195PSMC5 PRS8_HUMAN#26S proteasome regulatory subunit 8rMAPK cascade,protein polyubiquitination,stimulatory C-type lectin receptor signaling pathway,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent,transcription from RNA polymerase II promoter,regulation of cellular amino acid metabolic process,negative regulation of G2/M transition of mitotic cell cycle,protein deubiquitination,ER-associated ubiquitin-dependent protein catabolic process,anaphase-promoting complex-dependent catabolic process,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process,tumor necrosis factor-mediated signaling pathway,NIK/NF-kappaB signaling,Fc-epsilon receptor signaling pathway,negative regulation of programmed cell death,proteasome-mediated ubiquitin-dependent protein catabolic process,regulation of mRNA stability,negative regulation of transcription, DNA-templated,positive regulation of transcription, DNA-templated,positive regulation of RNA polymerase II transcriptional preinitiation complex assembly,modulation of synaptic transmission,T cell receptor signaling pathway,negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition,transmembrane transport,Wnt signaling pathway, planar cell polarity pathway,regulation of transcription from RNA polymerase II promoter in response to hypoxia,negative regulation of canonical Wnt signaling pathway,positive regulation of inclusion body assembly,positive regulation of canonical Wnt signaling pathway,positive regulation of proteasomal protein catabolic processtranscription cofactor activity,protein binding,ATP binding,transcription factor binding,ATPase activity,TBP-class protein binding,thyrotropin-releasing hormone receptor binding,proteasome-activating ATPase activityproteasome complex,nucleus,nucleoplasm,cytoplasm,cytosol,proteasome regulatory particle, base subcomplex,membrane,inclusion body,proteasome accessory comp< lex,cytoplasmic vesicle,nuclear proteasome complex,cytosolic proteasome complex,extracellular exosome,blood microparticle,postsynapsed>sp|P62195|PRS8_HUMAN 26S proteasome regulatory subunit 8 OS=Homo sapiens OX=9606 GN=PSMC5 PE=1 SV=1O00231PSMD11 PSD11_HUMAN/26S proteasome non-ATPase regulatory subunit 11MAPK cascade,protein polyubiquitination,stimulatory C-type lectin receptor signaling pathway,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent,ubiquitin-dependent protein catabolic process,regulation of cellular amino acid metabolic process,negative regulation of G2/M transition of mitotic cell cycle,protein deubiquitination,anaphase-promoting complex-dependent catabolic process,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process,tumor necrosis factor-mediated signaling pathway,NIK/NF-kappaB signaling,Fc-epsilon receptor signaling pathway,proteasome-mediated ubiquitin-dependent protein catabolic process,proteasome assembly,neutrophil degranulation,regulation of mRNA stability,stem cell differentiation,T cell receptor signaling pathway,negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition,transmembrane transport,Wnt signaling pathway, planar cell polarity pathway,regulation of transcription from RNA polymerase II promoter in response to hypoxia,negative regulation of canonical Wnt signaling pathway,positive regulation of canonical Wnt signaling pathwayr>sp|O00231|PSD11_HUMAN 26S proteasome non-ATPase regulatory subunit 11 OS=Homo sapiens OX=9606 GN=PSMD11 PE=1 SV=3P35606COPB2 COPB2_HUMANCoatomer subunit beta'X>sp|P35606|COPB2_HUMAN Coatomer subunit beta' OS=Homo sapiens OX=9606 GN=COPB2 PE=1 SV=2Q9Y4K0LOXL2 LOXL2_HUMANLysyl oxidase homolog 2response to hypoxia,epithelial to mesenchymal transition,endothelial cell proliferation,sprouting angiogenesis,transcription, DNA-templated,cellular protein modification process,receptor-mediated endocytosis,cell adhesion,aging,histone modification,protein deamination,collagen fibril organization,positive regulation of chondrocyte differentiation,endothelial cell migration,negative regulation of transcription, DNA-templated,response to copper ion,oxidation-reduction processchromatin binding,transcription corepressor activity,protein-lysine 6-oxidase activity,scavenger receptor activity,copper ion binding,protein binding,electron carrier activity,methylated histone binding,oligosaccharide bindingbbasement membrane,extracellular space,nucleus,nucleoplasm,chromosome,membrane,extracellular matrixY>sp|Q9Y4K0|LOXL2_HUMAN Lysyl oxidase homolog 2 OS=Homo sapiens OX=9606 GN=LOXL2 PE=1 SV=1P11021HSPA5 BIP_HUMAN#Endoplasmic reticulum chaperone BiPeER overload response,activation of signaling protein activity involved in unfolded protein response,response to radiation,positive regulation of neuron projection development,cerebellum structural organization,cerebellar Purkinje cell layer development,substantia nigra development,neuron differentiation,positive regulation of cell migration,ER-associated ubiquitin-dependent protein catabolic process,negative regulation of transforming growth factor beta receptor signaling pathway,endoplasmic reticulum unfolded protein response,positive regulation of protein ubiquitination,protein folding in endoplasmic reticulum,maintenance of protein localization in endoplasmic reticulum,cellular response to drug,IRE1-mediated unfolded protein response,PERK-mediated unfolded protein response,ATF6-mediated unfolded protein response,cellular response to glucose starvation,response to cocaine,negative regulation of apoptotic process,neuron apoptotic process,regulation of protein folding in endoplasmic reticulum,cellular response to antibiotic,cellular response to calcium ion,cellular response to manganese ion,cellular response to cAMP,cellular response to interleukin-4,negative regulation of protein homodimerization activity,stress response to metal ion,toxin transport,regulation of ATF6-mediated unfolded protein response,regulation of IRE1-mediated unfolded protein response,regulation of PERK-mediated unfolded protein response,response to methamphetamine hydrochloride,cellular response to nerve growth factor stimulus,positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress glycoprotein binding,calcium ion binding,protein binding,ATP binding,ATPase activity,enzyme binding,protein domain specific binding,ubiquitin protein ligase binding,ribosome binding,cadherin binding,unfolded protein binding,chaperone binding,misfolded protein bindingnucleus,mitochondrion,endoplasmic reticulum,endoplasmic reticulum lumen,endoplasmic reticulum membrane,smooth endoplasmic reticulum,endoplasmic reticulum-Golgi intermediate compartment,plasma membrane,focal adhesion,cell surface,membrane,integral component of endoplasmic reticulum membrane,midbody,extracellular matrix,endoplasmic reticulum chaperone complex,melanosome,myelin sheath,extracellular exosome,COP9 signalosomec>sp|P11021|BIP_HUMAN Endoplasmic reticulum chaperone BiP OS=Homo sapiens OX=9606 GN=HSPA5 PE=1 SV=2P00533EGFR EGFR_HUMAN Epidermal growth factor receptorp MAPK cascade,activation of MAPKK activity,ossification,embryonic placenta development,positive regulation of protein phosphorylation,hair follicle development,regulation of transcription from RNA polymerase II promoter,translation,response to stress,response to osmotic stress,response to oxidative stress,signal transduction,cell surface receptor signaling pathway,epidermal growth factor receptor signaling pathway,activation of phospholipase C activity,salivary gland morphogenesis,midgut development,learning or memory,circadian rhythm,cell proliferation,positive regulation of cell proliferation,magnesium ion homeostasis,regulation of phosphatidylinositol 3-kinase signaling,diterpenoid metabolic process,single organismal cell-cell adhesion,peptidyl-tyrosine phosphorylation,cerebral cortex cell migration,positive regulation of cell growth,lung development,positive regulation of cell migration,positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle,positive regulation of superoxide anion generation,response to cobalamin,response to hydroxyisoflavone,positive regulation of catenin import into nucleus,cellular response to drug,peptidyl-tyrosine autophosphorylation,ERBB2 signaling pathway,negative regulation of epidermal growth factor receptor signaling pathway,wound healing,negative regulation of protein catabolic process,positive regulation of phosphorylation,ovulation cycle,hydrogen peroxide metabolic process,activation of phospholipase A2 activity by calcium-mediated signaling,negative regulation of apoptotic process,positive regulation of MAP kinase activity,positive regulation of GTPase activity,tongue development,positive regulation of nitric oxide biosynthetic process,positive regulation of DNA repair,positive regulation of DNA replication,positive regulation of bone resorption,positive regulation of vasoconstriction,negative regulation of mitotic cell cycle,positive regulation of transcription from RNA polymerase II promoter,protein autophosphorylation,phosphatidylinositol phosphorylation,phosphatidylinositol-mediated signaling,astrocyte activation,positive regulation of fibroblast proliferation,digestive tract morphogenesis,positive regulation of smooth muscle cell proliferation,neuron projection morphogenesis,positive regulation of epithelial cell proliferation,positive regulation of inflammatory response,regulation of peptidyl-tyrosine phosphorylation,regulation of nitric-oxide synthase activity,protein insertion into membrane,response to calcium ion,positive regulation of protein kinase B signaling,positive regulation of synaptic transmission, glutamatergic,morphogenesis of an epithelial fold,membrane organization,eyelid development in camera-type eye,response to UV-A,positive regulation of ERK1 < and ERK2 cascade,cellular response to amino acid stimulus,cellular response to mechanical stimulus,cellular response to epidermal growth factor stimulus,cellular response to estradiol stimulus,cellular response to dexamethasone stimulus,liver regeneration,positive regulation of protein kinase C activity,negative regulation of ERBB signaling pathway,positive regulation of prolactin secretion,positive regulation of protein localization to plasma membrane,positive regulation of production of miRNAs involved in gene silencing by miRNA,negative regulation of cardiocyte differentiation,regulation of cell motilityglycoprotein binding,chromatin binding,double-stranded DNA binding,MAP kinase kinase kinase activity,protein tyrosine kinase activity,transmembrane receptor protein tyrosine kinase activity,receptor signaling protein tyrosine kinase activity,transmembrane signaling receptor activity,epidermal growth factor-activated receptor activity,Ras guanyl-nucleotide exchange factor activity,integrin binding,protein binding,calmodulin binding,ATP binding,enzyme binding,protein kinase binding,protein phosphatase binding,ubiquitin protein ligase binding,identical protein binding,cadherin binding,phosphatidylinositol-4,5-bisphosphate 3-kinase activity,protein heterodimerization activity,epidermal growth factor binding,actin filament binding,nitric-oxide synthase regulator activityGolgi membrane,extracellular space,nucleus,cytoplasm,endosome,endoplasmic reticulum membrane,plasma membrane,focal adhesion,cell surface,endosome membrane,membrane,integral component of membrane,basolateral plasma membrane,apical plasma membrane,clathrin-coated vesicle membrane,early endosome membrane,nuclear membrane,receptor complex,membrane raft,synapse,perinuclear region of cytoplasm,Shc-EGFR complex,multivesicular body, internal vesicle lumen,AP-2 adaptor complex`>sp|P00533|EGFR_HUMAN Epidermal growth factor receptor OS=Homo sapiens OX=9606 GN=EGFR PE=1 SV=2Q96QK1VPS35 VPS35_HUMAN.Vacuolar protein sorting-associated protein 35Glysosome organization,positive regulation of gene expression,negative regulation of gene expression,regulation of mitochondrion organization,Wnt signaling pathway,regulation of macroautophagy,regulation of protein stability,protein destabilization,regulation of cellular protein metabolic process,negative regulation of protein homooligomerization,protein localization to organelle,retrograde transport, endosome to Golgi,mitochondrial fragmentation involved in apoptotic process,transcytosis,voluntary musculoskeletal movement,positive regulation of dopamine receptor signaling pathway,positive regulation of Wnt protein secretion,positive regulation of mitochondrial fission,positive regulation of canonical Wnt signaling pathway,positive regulation of locomotion involved in locomotory behavior,mitochondrion to lysosome transport,neurotransmitter receptor transport, endosome to plasma membrane,negative regulation of neuron death,negative regulation of late endosome to lysosome transport,regulation of dendritic spine maintenance,positive regulation of dopamine biosynthetic process,positive regulation of cellular protein catabolic process,negative regulation of cellular protein localization,negative regulation of lysosomal protein catabolic process,retrograde transport, endosome to plasma membrane,regulation of terminal button organizationIprotein binding,protein transporter activity,D1 dopamine receptor binding;lysosome,lysosomal membrane,endosome,early endosome,late endosome,cytosol,endosome membrane,postsynaptic density,retromer complex,retromer, cargo-selective complex,neuron projection,neuronal cell body,perinuclear region of cytoplasm,extracellular exosome,tubular endosome,mitochondrion-derived vesicle,mitochondrionp>sp|Q96QK1|VPS35_HUMAN Vacuolar protein sorting-associated protein 35 OS=Homo sapiens OX=9606 GN=VPS35 PE=1 SV=2P17655CAPN2 CAN2_HUMANCalpain-2 catalytic subunit response to hypoxia,blastocyst development,proteolysis,myoblast fusion,protein autoprocessing,extracellular matrix disassembly,regulation of cytoskeleton organization,proteolysis involved in cellular protein catabolic process,cellular response to amino acid stimuluscalcium-dependent cysteine-type endopeptidase activity,calcium ion binding,protein binding,cytoskeletal protein binding,cysteine-type peptidase activity,protein heterodimerization activitychromatin,nucleus,cytoplasm,lysosome,endoplasmic reticulum,Golgi apparatus,cytosol,plasma membrane,focal adhesion,dendrite,cortical actin cytoskeleton,pseudopodium,membrane raft,extracellular exosome,perinuclear endoplasmic reticulum\>sp|P17655|CAN2_HUMAN Calpain-2 catalytic subunit OS=Homo sapiens OX=9606 GN=CAPN2 PE=1 SV=6Q99832CCT7 TCPH_HUMANT-complex protein 1 subunit etaprotein folding,'de novo' protein folding,binding of sperm to zona pellucida,positive regulation of telomere maintenance via telomerase,protein stabilization,chaperone-mediated protein folding,toxin transport,positive regulation of establishment of protein localization to telomere,positive regulation of protein localization to Cajal body,positive regulation of telomerase RNA localization to Cajal bodyzprotein binding,ATP binding,identical protein binding,protein binding involved in protein folding,unfolded protein bindingzona pellucida receptor complex,cytoplasm,mitochondrion,cytosol,chaperonin-containing T-complex,microtubule,cell body,extracellular exosome_>sp|Q99832|TCPH_HUMAN T-complex protein 1 subunit eta OS=Homo sapiens OX=9606 GN=CCT7 PE=1 SV=2Q99460PSMD1 PSMD1_HUMAN.26S proteasome non-ATPase regulatory subunit 1enzyme regulator activityproteasome complex,extracellular region,nucleoplasm,cytosol,proteasome regulatory particle,membrane,proteasome accessory complex,azurophil granule lumen,extracellular exosomep>sp|Q99460|PSMD1_HUMAN 26S proteasome non-ATPase regulatory subunit 1 OS=Homo sapiens OX=9606 GN=PSMD1 PE=1 SV=2Q16610ECM1 ECM1_HUMANExtracellular matrix protein 1ossification,angiogenesis,positive regulation of endothelial cell proliferation,negative regulation of cytokine-mediated signaling pathway,platelet degranulation,regulation of type 2 immune response,regulation of transcription from RNA polymerase II promoter,inflammatory response,signal transduction,negative regulation of peptidase activity,negative regulation of bone mineralization,biomineral tissue development,positive regulation of I-kappaB kinase/NF-kappaB signaling,positive regulation of angiogenesis,regulation of T cell migrationprotease binding,signal transducer activity,interleukin-2 receptor binding,protein binding,protein C-terminus binding,enzyme binding,laminin bindingextracellular region,proteinaceous extracellular matrix,extracellular space,extracellular matrix,platelet dense granule lumen,extracellular exosome^>sp|Q16610|ECM1_HUMAN Extracellular matrix protein 1 OS=Homo sapiens OX=9606 GN=ECM1 PE=1 SV=2P50991CCT4 TCPD_HUMAN!T-complex protein 1 subunit deltaprotein folding,'de novo' protein folding,binding of sperm to zona pellucida,positive regulation of telomere maintenance via telomerase,protein stabilization,positive regulation of telomerase activity,chaperone-mediated protein folding,scaRNA localization to Cajal body,toxin transport,positive regulation of establishment of protein localization to telomere,positive regulation of protein localization to Cajal body,positive regulation of telomerase RNA localization to Cajal bodylRNA binding,protein binding,ATP binding,protein binding involved in protein folding,unfolded protein bindingzona pellucida receptor complex,nucleoplasm,centrosome,cytosol,chaperonin-containing T-complex,microtubule,melanosome,cell projection,cell body,extracellular exosomea>sp|P50991|TCPD_HUMAN T-complex protein 1 subunit delta OS=Homo sapiens OX=9606 GN=CCT4 PE=1 SV=4P14210HGF HGF_HUMANHepatocyte growth factorMAPK cascade,activation of MAPK activity,cell morphogenesis,epithelial to mesenchymal transition,liver development,platelet degranulation,mitotic nuclear division,positive regulation of cell proliferation,negative regulation of autophagy,< regulation of phosphatidylinositol 3-kinase signaling,positive regulation of phosphatidylinositol 3-kinase signaling,peptidyl-tyrosine phosphorylation,hyaluronan metabolic process,positive regulation of cell migration,animal organ regeneration,positive regulation of myelination,negative regulation of interleukin-6 production,positive regulation of interleukin-10 production,negative regulation of peptidyl-serine phosphorylation,cellular response to hepatocyte growth factor stimulus,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process,positive regulation of GTPase activity,positive regulation of osteoblast differentiation,positive regulation of angiogenesis,positive regulation of transcription from RNA polymerase II promoter,phosphatidylinositol phosphorylation,hepatocyte growth factor receptor signaling pathway,phosphatidylinositol-mediated signaling,negative regulation of inflammatory response,positive regulation of peptidyl-tyrosine phosphorylation,positive chemotaxis,myoblast proliferation,cell chemotaxis,regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling,positive regulation of neuron projection regeneration,negative regulation of release of cytochrome c from mitochondria,regulation of p38MAPK cascade,negative regulation of hydrogen peroxide-mediated programmed cell death,negative regulation of extrinsic apoptotic signaling pathway via death domain receptors,regulation of tau-protein kinase activity,positive regulation of DNA biosynthetic process,proteolysisprotein tyrosine kinase activity,Ras guanyl-nucleotide exchange factor activity,protein binding,growth factor activity,chemoattractant activity,phosphatidylinositol-4,5-bisphosphate 3-kinase activity,protein heterodimerization activity,serine-type endopeptidase activityNextracellular region,extracellular space,membrane,platelet alpha granule lumenV>sp|P14210|HGF_HUMAN Hepatocyte growth factor OS=Homo sapiens OX=9606 GN=HGF PE=1 SV=2P13674P4HA1 P4HA1_HUMAN$Prolyl 4-hydroxylase subunit alpha-1npeptidyl-proline hydroxylation to 4-hydroxy-L-proline,collagen fibril organization,oxidation-reduction processprocollagen-proline 4-dioxygenase activity,iron ion binding,protein binding,oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen,L-ascorbic acid bindingmitochondrion,endoplasmic reticulum,endoplasmic reticulum lumen,membrane,procollagen-proline 4-dioxygenase complex,intracellular membrane-bounded organellef>sp|P13674|P4HA1_HUMAN Prolyl 4-hydroxylase subunit alpha-1 OS=Homo sapiens OX=9606 GN=P4HA1 PE=1 SV=2P53618COPB1 COPB_HUMANCoatomer subunit betaintracellular protein transport,ER to Golgi vesicle-mediated transport,retrograde vesicle-mediated transport, Golgi to ER,intra-Golgi vesicle-mediated transport,viral process,neutrophil degranulationNGolgi membrane,endoplasmic reticulum membrane,endoplasmic reticulum-Golgi intermediate compartment,Golgi apparatus,Golgi-associated vesicle,cytosol,plasma membrane,membrane,COPI vesicle coat,transport vesicle,secretory granule membrane,intracellular membrane-bounded organelle,tertiary granule membrane,ficolin-1-rich granule membraneV>sp|P53618|COPB_HUMAN Coatomer subunit beta OS=Homo sapiens OX=9606 GN=COPB1 PE=1 SV=3P11216PYGB PYGB_HUMAN"Glycogen phosphorylase, brain form3glycogen catabolic process,neutrophil degranulationKprotein binding,glycogen phosphorylase activity,pyridoxal phosphate bindingUextracellular region,cytoplasm,membrane,azurophil granule lumen,extracellular exosomeb>sp|P11216|PYGB_HUMAN Glycogen phosphorylase, brain form OS=Homo sapiens OX=9606 GN=PYGB PE=1 SV=5Q86UP2KTN1 KTN1_HUMANKinectinmicrotubule-based movement<RNA binding,protein binding,kinesin binding,cadherin bindingendoplasmic reticulum,endoplasmic reticulum membrane,integral component of plasma membrane,membrane,integral component of membraneH>sp|Q86UP2|KTN1_HUMAN Kinectin OS=Homo sapiens OX=9606 GN=KTN1 PE=1 SV=1P26640VARS1 SYVC_HUMANValine--tRNA ligasejtRNA aminoacylation for protein translation,valyl-tRNA aminoacylation,regulation of translational fidelityWaminoacyl-tRNA editing activity,valine-tRNA ligase activity,protein binding,ATP bindingT>sp|P26640|SYVC_HUMAN Valine--tRNA ligase OS=Homo sapiens OX=9606 GN=VARS1 PE=1 SV=4Q15113PCOLCE PCOC1_HUMAN&Procollagen C-endopeptidase enhancer 1Xproteolysis,multicellular organism development,positive regulation of peptidase activityMprotein binding,collagen binding,heparin binding,peptidase activator activity>extracellular space,extracellular exosome,extracellular matrixi>sp|Q15113|PCOC1_HUMAN Procollagen C-endopeptidase enhancer 1 OS=Homo sapiens OX=9606 GN=PCOLCE PE=1 SV=2Q08431MFGE8 MFGM_HUMAN Lactadherinangiogenesis,phagocytosis, recognition,phagocytosis, engulfment,cell adhesion,single fertilization,viral process,cellular protein metabolic process,positive regulation of apoptotic cell clearanceLphosphatidylserine binding,integrin binding,phosphatidylethanolamine bindingextracellular region,extracellular space,external side of plasma membrane,membrane,extrinsic component of plasma membrane,extracellular exosome,extracellular vesicle,extracellular matrixL>sp|Q08431|MFGM_HUMAN Lactadherin OS=Homo sapiens OX=9606 GN=MFGE8 PE=1 SV=3P08253MMP2 MMP2_HUMAN72 kDa type IV collagenaseangiogenesis,response to hypoxia,blood vessel maturation,intramembranous ossification,proteolysis,embryo implantation,extracellular matrix disassembly,collagen catabolic process,endodermal cell differentiation,cellular protein metabolic process,positive regulation of innate immune response,ephrin receptor signaling pathway,face morphogenesis,bone trabecula formation,cellular response to amino acid stimulus,positive regulation of vascular smooth muscle cell proliferation{metalloendopeptidase activity,serine-type endopeptidase activity,protein binding,metallopeptidase activity,zinc ion bindingextracellular region,proteinaceous extracellular matrix,extracellular space,nucleus,mitochondrion,plasma membrane,sarcomere,extracellular matrixZ>sp|P08253|MMP2_HUMAN 72 kDa type IV collagenase OS=Homo sapiens OX=9606 GN=MMP2 PE=1 SV=2P14625HSP90B1 ENPL_HUMAN Endoplasminresponse to hypoxia,toll-like receptor signaling pathway,receptor-mediated endocytosis,protein transport,ER-associated ubiquitin-dependent protein catabolic process,retrograde protein transport, ER to cytosol,actin rod assembly,protein folding in endoplasmic reticulum,response to endoplasmic reticulum stress,ATF6-mediated unfolded protein response,negative regulation of apoptotic process,regulation of phosphoprotein phosphatase activity,sequestering of calcium ion,cellular response to ATPRNA binding,calcium ion binding,protein binding,ATP binding,protein phosphatase binding,virion binding,low-density lipoprotein particle receptor binding,unfolded protein binding;extracellular region,nucleus,endoplasmic reticulum,endoplasmic reticulum lumen,endoplasmic reticulum membrane,cytosol,plasma membrane,focal adhesion,membrane,midbody,extracellular matrix,endoplasmic reticulum chaperone complex,melanosome,perinuclear region of cytoplasm,extracellular exosome,endocytic vesicle lumenN>sp|P14625|ENPL_HUMAN Endoplasmin OS=Homo sapiens OX=9606 GN=HSP90B1 PE=1 SV=1P00736C1R C1R_HUMANComplement C1r subcomponentqproteolysis,immune response,complement activation,complement activation, classical pathway,innate immune responseeserine-type endopeptidase activity,calcium ion binding,protein binding,serine-type peptidase activityY>sp|P00736|C1R_HUMAN Complement C1r subcomponent OS=Homo sapiens OX=9606 GN=C1R PE=1 SV=2Q71U36TUBA1A TBA1A_HUMANTubulin alpha-1A chainG2/M transition of mitotic cell cycle,cytoskeleton organization,microtubule-based process,cytoskeleton-dependent intracellular transport,cell division,ciliary basal body dockingGTPase activity,structural molecule activity,structural constituent of cytoskeleton,protein binding,GTP binding,protein domain specific binding< nucleus,cytosol,microtubule,cytoplasmic microtubule,microtubule cytoskeleton,cytoplasmic ribonucleoprotein granule,myelin sheath,recycling endosome,extracellular exosomeY>sp|Q71U36|TBA1A_HUMAN Tubulin alpha-1A chain OS=Homo sapiens OX=9606 GN=TUBA1A PE=1 SV=1P41250GARS1 GARS_HUMANGlycine--tRNA ligasevtRNA aminoacylation for protein translation,glycyl-tRNA aminoacylation,diadenosine tetraphosphate biosynthetic processbis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity,glycine-tRNA ligase activity,ATP binding,protein dimerization activityScytoplasm,mitochondrial matrix,cytosol,secretory granule,axon,extracellular exosomeU>sp|P41250|GARS_HUMAN Glycine--tRNA ligase OS=Homo sapiens OX=9606 GN=GARS1 PE=1 SV=3P55072VCP TERA_HUMAN)Transitional endoplasmic reticulum ATPaseDNA repair,double-strand break repair,protein folding,protein methylation,NADH metabolic process,ER to Golgi vesicle-mediated transport,autophagy,activation of cysteine-type endopeptidase activity involved in apoptotic process,cellular response to DNA damage stimulus,positive regulation of mitochondrial membrane potential,protein ubiquitination,protein deubiquitination,protein N-linked glycosylation via asparagine,viral genome replication,translesion synthesis,ER-associated ubiquitin-dependent protein catabolic process,endoplasmic reticulum unfolded protein response,retrograde protein transport, ER to cytosol,positive regulation of protein complex assembly,positive regulation of proteasomal ubiquitin-dependent protein catabolic process,protein hexamerization,ERAD pathway,regulation of apoptotic process,proteasome-mediated ubiquitin-dependent protein catabolic process,neutrophil degranulation,establishment of protein localization,positive regulation of protein catabolic process,ATP metabolic process,protein homooligomerization,transmembrane transport,aggresome assembly,error-free translesion synthesis,ER-associated misfolded protein catabolic process,flavin adenine dinucleotide catabolic process,autophagosome maturation,positive regulation of protein K63-linked deubiquitination,positive regulation of Lys63-specific deubiquitinase activity,regulation of aerobic respiration,positive regulation of oxidative phosphorylation,positive regulation of ubiquitin-specific protease activity,positive regulation of ATP biosynthetic processRNA binding,protein binding,ATP binding,lipid binding,ATPase activity,protein phosphatase binding,protein domain specific binding,polyubiquitin binding,ubiquitin protein ligase binding,deubiquitinase activator activity,K48-linked polyubiquitin binding,MHC class I protein binding,identical protein binding,ADP binding,ubiquitin-like protein ligase binding,BAT3 complex binding,ubiquitin-specific protease bindingproteasome complex,extracellular region,nucleus,nucleoplasm,endoplasmic reticulum,endoplasmic reticulum membrane,lipid particle,cytosol,VCP-NPL4-UFD1 AAA ATPase complex,secretory granule lumen,azurophil granule lumen,site of double-strand break,Derlin-1 retrotranslocation complex,myelin sheath,intracellular membrane-bounded organelle,perinuclear region of cytoplasm,extracellular exosome,ficolin-1-rich granule lumen,VCP-NSFL1C complexh>sp|P55072|TERA_HUMAN Transitional endoplasmic reticulum ATPase OS=Homo sapiens OX=9606 GN=VCP PE=1 SV=4P04083ANXA1 ANXA1_HUMAN Annexin A1DNA strand renaturation,neutrophil homeostasis,adaptive immune response,monocyte chemotaxis,regulation of leukocyte migration,phagocytosis,inflammatory response,signal transduction,cell surface receptor signaling pathway,G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger,regulation of cell shape,response to X-ray,myoblast migration involved in skeletal muscle regeneration,peptide cross-linking,insulin secretion,keratinocyte differentiation,prostate gland development,endocrine pancreas development,positive regulation of vesicle fusion,positive regulation of prostaglandin biosynthetic process,actin cytoskeleton reorganization,response to estradiol,DNA duplex unwinding,regulation of interleukin-1 production,positive regulation of interleukin-2 production,positive regulation of neutrophil apoptotic process,DNA rewinding,gliogenesis,positive regulation of T cell proliferation,response to drug,negative regulation of apoptotic process,response to peptide hormone,estrous cycle,innate immune response,positive regulation of T-helper 1 cell differentiation,negative regulation of T-helper 2 cell differentiation,negative regulation of exocytosis,alpha-beta T cell differentiation,regulation of hormone secretion,arachidonic acid secretion,regulation of inflammatory response,cellular response to hydrogen peroxide,hepatocyte differentiation,prolactin secretion,response to interleukin-1,cellular response to glucocorticoid stimulus,granulocyte chemotaxis,positive regulation of wound healing,neutrophil clearance,cell-cell adhesion,positive regulation of G1/S transition of mitotic cell cycle,negative regulation of phospholipase A2 activity,negative regulation of interleukin-8 secretionsingle-stranded DNA binding,single-stranded RNA binding,helicase activity,receptor binding,structural molecule activity,calcium ion binding,protein binding,phospholipid binding,calcium-dependent phospholipid binding,phospholipase A2 inhibitor activity,protein binding, bridging,double-stranded DNA-dependent ATPase activity,annealing helicase activity,protein homodimerization activity,calcium-dependent protein binding,cadherin binding involved in cell-cell adhesion2cornified envelope,phagocytic cup,extracellular region,extracellular space,nucleus,nucleoplasm,cytoplasm,endosome,cytosol,plasma membrane,cell-cell adherens junction,focal adhesion,cell surface,basolateral plasma membrane,apical plasma membrane,lateral plasma membrane,extrinsic component of membrane,cytoplasmic vesicle membrane,extrinsic component of external side of plasma membrane,extrinsic component of endosome membrane,motile cilium,early endosome membrane,mitochondrial membrane,vesicle,sarcolemma,mast cell granule,protein complex,extracellular exosomeL>sp|P04083|ANXA1_HUMAN Annexin A1 OS=Homo sapiens OX=9606 GN=ANXA1 PE=1 SV=2P07237P4HB PDIA1_HUMANProtein disulfide-isomerasefresponse to reactive oxygen species,protein folding,peptidyl-proline hydroxylation to 4-hydroxy-L-proline,response to endoplasmic reticulum stress,lipoprotein biosynthetic process,cell redox homeostasis,positive regulation of viral entry into host cell,cellular response to hypoxia,regulation of oxidative stress-induced intrinsic apoptotic signaling pathwayRNA binding,protein disulfide isomerase activity,integrin binding,protein binding,enzyme binding,protein heterodimerization activity,procollagen-proline 4-dioxygenase activity3extracellular region,endoplasmic reticulum,endoplasmic reticulum lumen,endoplasmic reticulum-Golgi intermediate compartment,focal adhesion,external side of plasma membrane,procollagen-proline 4-dioxygenase complex,extracellular matrix,endoplasmic reticulum chaperone complex,melanosome,extracellular exosome\>sp|P07237|PDIA1_HUMAN Protein disulfide-isomerase OS=Homo sapiens OX=9606 GN=P4HB PE=1 SV=3P55268LAMB2 LAMB2_HUMANLaminin subunit beta-2`cell adhesion,axon guidance,neuromuscular junction development,visual perception,astrocyte development,Schwann cell development,extracellular matrix organization,axon extension involved in regeneration,retina development in camera-type eye,metanephric glomerular visceral epithelial cell development,metanephric glomerular basement membrane development-integrin binding,structural molecule activityextracellular region,basement membrane,basal lamina,laminin-3 complex,extracellular space,synaptic cleft,laminin-11 complex,extracellular exosome,extracellular matrixX>sp|P55268|LAMB2_HUMAN Laminin subunit beta-2 OS=Homo sapiens OX=9606 GN=LAMB2 PE=1 SV=2Q9NZN4EHD2 EHD2_HUMANEH domain-containing protein 2endocytosis,blood coagulation,cortical actin cytoskeleton organization,endocytic recycling,protein localization to plasma membrane,membrane tubulation,positive regulation of myoblast fusion,positive regulation < of endocytic recyclingnucleic acid binding,calcium ion binding,protein binding,ATP binding,GTP binding,hydrolase activity,protein domain specific bindingnucleus,cytosol,plasma membrane,caveola,endosome membrane,microtubule cytoskeleton,extrinsic component of membrane,intercellular bridge,perinuclear region of cytoplasm,recycling endosome membrane,extracellular exosome^>sp|Q9NZN4|EHD2_HUMAN EH domain-containing protein 2 OS=Homo sapiens OX=9606 GN=EHD2 PE=1 SV=2P06396GSN GELS_HUMANGelsolinphagocytosis, engulfment,aging,positive regulation of gene expression,oligodendrocyte development,striated muscle atrophy,actin filament polymerization,protein destabilization,tissue regeneration,sequestering of actin monomers,neutrophil degranulation,cellular protein metabolic process,actin nucleation,response to ethanol,negative regulation of viral entry into host cell,phosphatidylinositol-mediated signaling,actin filament severing,barbed-end actin filament capping,positive regulation of actin nucleation,response to folic acid,actin filament capping,cilium morphogenesis,cellular response to cadmium ion,regulation of podosome assembly,actin filament reorganization,renal protein absorption,hepatocyte apoptotic process,positive regulation of keratinocyte apoptotic process,regulation of wound healing, spreading of epidermal cells,regulation of establishment of T cell polarity,regulation of plasma membrane raft polarization,regulation of receptor clustering,positive regulation of protein processing in phagocytic vesicle,amyloid fibril formation,positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway,extracellular matrix disassemblycactin binding,calcium ion binding,protein binding,protein domain specific binding,myosin II bindingPruffle,podosome,extracellular region,extracellular space,cytoplasm,cytosol,plasma membrane,focal adhesion,actin cytoskeleton,sarcoplasm,lamellipodium,actin cap,cortical actin cytoskeleton,secretory granule lumen,myelin sheath,perinuclear region of cytoplasm,extracellular exosome,blood microparticle,ficolin-1-rich granule lumen,nucleusG>sp|P06396|GELS_HUMAN Gelsolin OS=Homo sapiens OX=9606 GN=GSN PE=1 SV=1A1L4H1SSC5D SRCRL_HUMANHSoluble scavenger receptor cysteine-rich domain-containing protein SSC5Dreceptor-mediated endocytosis,multicellular organism development,detection of bacterial lipoprotein,innate immune response,defense response to Gram-negative bacterium,defense response to Gram-positive bacterium,negative regulation of interleukin-8 secretionlfibronectin binding,scavenger receptor activity,protein binding,laminin binding,extracellular matrix bindingIextracellular space,intracellular,cytoplasm,membrane,extracellular matrix>sp|A1L4H1|SRCRL_HUMAN Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D OS=Homo sapiens OX=9606 GN=SSC5D PE=1 SV=3Q14766LTBP1 LTBP1_HUMAN8Latent-transforming growth factor beta-binding protein 1ventricular septum development,transmembrane receptor protein serine/threonine kinase signaling pathway,sequestering of TGFbeta in extracellular matrix,aorta development,coronary vasculature developmenttransforming growth factor beta-activated receptor activity,calcium ion binding,protein binding,transforming growth factor beta binding,microfibril binding|microfibril,extracellular region,proteinaceous extracellular matrix,extracellular space,extracellular matrix,protein complexz>sp|Q14766|LTBP1_HUMAN Latent-transforming growth factor beta-binding protein 1 OS=Homo sapiens OX=9606 GN=LTBP1 PE=1 SV=4P78527PRKDC PRKDC_HUMAN.DNA-dependent protein kinase catalytic subunitsomitogenesis,negative regulation of protein phosphorylation,B cell lineage commitment,pro-B cell differentiation,T cell lineage commitment,negative regulation of immunoglobulin production,positive regulation of immune system process,double-strand break repair,double-strand break repair via nonhomologous end joining,cellular protein modification process,brain development,heart development,cell proliferation,intrinsic apoptotic signaling pathway in response to DNA damage,response to gamma radiation,response to activity,telomere capping,protein ubiquitination,peptidyl-serine phosphorylation,protein destabilization,positive regulation of type I interferon production,cellular response to insulin stimulus,T cell differentiation in thymus,immunoglobulin V(D)J recombination,T cell receptor V(D)J recombination,ectopic germ cell programmed cell death,regulation of circadian rhythm,positive regulation of apoptotic process,negative regulation of apoptotic process,positive regulation of transcription from RNA polymerase II promoter,positive regulation of fibroblast proliferation,rhythmic process,spleen development,thymus development,positive regulation of developmental growth,regulation of smooth muscle cell proliferation,signal transduction involved in mitotic G1 DNA damage checkpoint,double-strand break repair via alternative nonhomologous end joining,negative regulation of cellular senescence,negative regulation of response to gamma radiationdouble-stranded DNA binding,RNA binding,protein kinase activity,protein serine/threonine kinase activity,DNA-dependent protein kinase activity,protein binding,ATP binding,transcription factor binding,enzyme bindingnuclear chromosome, telomeric region,nucleoplasm,transcription factor complex,nucleolus,cytosol,DNA-dependent protein kinase-DNA ligase 4 complex,membrane,extracellular matrix,nonhomologous end joining complexp>sp|P78527|PRKDC_HUMAN DNA-dependent protein kinase catalytic subunit OS=Homo sapiens OX=9606 GN=PRKDC PE=1 SV=3P27708CAD PYR1_HUMAN CAD proteinVliver development,'de novo' pyrimidine nucleobase biosynthetic process,UTP biosynthetic process,glutamine metabolic process,heart development,female pregnancy,lactation,response to amine,drug metabolic process,peptidyl-threonine phosphorylation,citrulline biosynthetic process,response to caffeine,animal organ regeneration,response to insulin,response to testosterone,cellular response to drug,response to starvation,'de novo' UMP biosynthetic process,pyrimidine nucleoside biosynthetic process,protein autophosphorylation,response to cortisol,cellular response to epidermal growth factor stimulusaspartate carbamoyltransferase activity,carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity,dihydroorotase activity,protein kinase activity,ATP binding,zinc ion binding,enzyme binding,identical protein binding,aspartate bindingnucleus,nucleoplasm,cytosol,membrane,nuclear matrix,cell projection,neuronal cell body,terminal bouton,protein complex,extracellular exosomeJ>sp|P27708|PYR1_HUMAN CAD protein OS=Homo sapiens OX=9606 GN=CAD PE=1 SV=3Q96RW7HMCN1 HMCN1_HUMAN Hemicentin-1?cell cycle,visual perception,response to stimulus,cell divisionfbasement membrane,cell cortex,cell junction,cleavage furrow,extracellular exosome,extracellular matrixN>sp|Q96RW7|HMCN1_HUMAN Hemicentin-1 OS=Homo sapiens OX=9606 GN=HMCN1 PE=1 SV=2Q01813PFKP PFKAP_HUMAN2ATP-dependent 6-phosphofructokinase, platelet type;fructose 6-phosphate metabolic process,canonical glycolysise6-phosphofructokinase activity,ATP binding,protein complex binding,cadherin binding,metal ion bindingMnucleus,cytoplasm,cytosol,membrane,extracellular matrix,extracellular exosomes>sp|Q01813|PFKAP_HUMAN ATP-dependent 6-phosphofructokinase, platelet type OS=Homo sapiens OX=9606 GN=PFKP PE=1 SV=2P14868DARS1 SYDC_HUMAN#Aspartate--tRNA ligase, cytoplasmicmtranslation,tRNA aminoacylation for protein translation,aspartyl-tRNA aminoacylation,protein complex assembly\RNA binding,aminoacylase activity,aspartate-tRNA ligase activity,protein binding,ATP bindingd>sp|P14868|SYDC_HUMAN Aspartate--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=DARS1 PE=1 SV=2Q7Z304MAMDC2 MAMC2_HUMANMAM domain-containing protein 2Aproteinaceous extracellular matrix,endoplasmic reticulum,membraneb>sp|Q7Z304|MAMC2_HUMAN MAM domain-containing protein 2 OS=Homo sapiens OX=9606 GN=MAMDC2 PE=1 SV=3P68371TUBB4B TBB4B_HUMANTubulin beta-4B chain< G2/M transition of mitotic cell cycle,movement of cell or subcellular component,cytoskeleton organization,microtubule-based process,natural killer cell mediated cytotoxicity,neutrophil degranulation,ciliary basal body dockingdouble-stranded RNA binding,GTPase activity,structural constituent of cytoskeleton,GTP binding,MHC class I protein binding,unfolded protein bindingextracellular region,nucleus,cytosol,cytoskeleton,microtubule,microtubule cytoskeleton,extracellular matrix,azurophil granule lumen,myelin sheath,extracellular exosome,extracellular vesicleX>sp|P68371|TBB4B_HUMAN Tubulin beta-4B chain OS=Homo sapiens OX=9606 GN=TUBB4B PE=1 SV=1Q9H5V8CDCP1 CDCP1_HUMANCUB domain-containing protein 1Cextracellular region,plasma membrane,integral component of membranea>sp|Q9H5V8|CDCP1_HUMAN CUB domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CDCP1 PE=1 SV=3P35998PSMC2 PRS7_HUMAN#26S proteasome regulatory subunit 7MAPK cascade,protein polyubiquitination,osteoblast differentiation,stimulatory C-type lectin receptor signaling pathway,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent,ubiquitin-dependent protein catabolic process,regulation of cellular amino acid metabolic process,negative regulation of G2/M transition of mitotic cell cycle,viral process,protein deubiquitination,ER-associated ubiquitin-dependent protein catabolic process,anaphase-promoting complex-dependent catabolic process,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process,tumor necrosis factor-mediated signaling pathway,NIK/NF-kappaB signaling,Fc-epsilon receptor signaling pathway,proteasome-mediated ubiquitin-dependent protein catabolic process,neutrophil degranulation,regulation of mRNA stability,positive regulation of RNA polymerase II transcriptional preinitiation complex assembly,T cell receptor signaling pathway,negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition,transmembrane transport,Wnt signaling pathway, planar cell polarity pathway,regulation of transcription from RNA polymerase II promoter in response to hypoxia,negative regulation of canonical Wnt signaling pathway,positive regulation of canonical Wnt signaling pathway,positive regulation of proteasomal protein catabolic process1proteasome complex,cytoplasmic mRNA processing body,extracellular region,nucleus,nucleoplasm,cytoplasm,cytosol,proteasome regulatory particle, base subcomplex,membrane,proteasome accessory complex,nuclear proteasome complex,cytosolic proteasome complex,secretory granule lumen,ficolin-1-rich granule lumend>sp|P35998|PRS7_HUMAN 26S proteasome regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PSMC2 PE=1 SV=3P63261ACTG1 ACTG_HUMANActin, cytoplasmic 2jretina homeostasis,movement of cell or subcellular component,response to mechanical stimulus,cell junction assembly,Fc-gamma receptor signaling pathway involved in phagocytosis,sarcomere organization,vascular endothelial growth factor receptor signaling pathway,ephrin receptor signaling pathway,response to calcium ion,membrane organization,platelet aggregation}structural constituent of cytoskeleton,protein binding,ATP binding,ubiquitin protein ligase binding,identical protein bindingextracellular space,nucleus,cytosol,cytoskeleton,plasma membrane,focal adhesion,membrane,myofibril,extracellular matrix,filamentous actin,myelin sheath,extracellular exosome,blood microparticle,dense bodyU>sp|P63261|ACTG_HUMAN Actin, cytoplasmic 2 OS=Homo sapiens OX=9606 GN=ACTG1 PE=1 SV=1P49368CCT3 TCPG_HUMAN!T-complex protein 1 subunit gammaaprotein folding,'de novo' protein folding,binding of sperm to zona pellucida,positive regulation of telomere maintenance via telomerase,pore complex assembly,protein stabilization,chaperone-mediated protein folding,toxin transport,positive regulation of protein localization to Cajal body,positive regulation of telomerase RNA localization to Cajal bodyzona pellucida receptor complex,cytosol,chaperonin-containing T-complex,cytoskeleton,microtubule,plasma membrane,myelin sheath,cell body,extracellular exosomea>sp|P49368|TCPG_HUMAN T-complex protein 1 subunit gamma OS=Homo sapiens OX=9606 GN=CCT3 PE=1 SV=4Q92616GCN1 GCN1_HUMAN!eIF-2-alpha kinase activator GCN1 translation,regulation of translation,positive regulation of kinase activity,cellular response to amino acid starvation,positive regulation of transcription from RNA polymerase II promoter in response to stress,regulation of protein kinase activity,cellular response to leucine starvationRNA binding,translation factor activity, RNA binding,protein kinase regulator activity,protein kinase binding,ribosome binding,cadherin binding,cytoplasm,cytosol,ribosome,polysome,membranea>sp|Q92616|GCN1_HUMAN eIF-2-alpha kinase activator GCN1 OS=Homo sapiens OX=9606 GN=GCN1 PE=1 SV=6Q08380LGALS3BP LG3BP_HUMANGalectin-3-binding proteinpplatelet degranulation,receptor-mediated endocytosis,cellular defense response,cell adhesion,signal transductionscavenger receptor activityextracellular region,proteinaceous extracellular matrix,extracellular space,membrane,platelet dense granule lumen,extracellular exosome,blood microparticle,extracellular matrix_>sp|Q08380|LG3BP_HUMAN Galectin-3-binding protein OS=Homo sapiens OX=9606 GN=LGALS3BP PE=1 SV=1P12956XRCC6 XRCC6_HUMAN*X-ray repair cross-complementing protein 6telomere maintenance,DNA ligation,double-strand break repair via nonhomologous end joining,DNA recombination,transcription, DNA-templated,brain development,positive regulation of type I interferon production,DNA duplex unwinding,neutrophil degranulation,negative regulation of transcription, DNA-templated,positive regulation of transcription, DNA-templated,positive regulation of transcription from RNA polymerase II promoter,regulation of smooth muscle cell proliferation,protein heterotetramerization,cellular hyperosmotic salinity response,cellular response to gamma radiation,cellular response to X-ray,establishment of integrated proviral latency,double-strand break repair via classical nonhomologous end joining=DNA binding,damaged DNA binding,double-stranded DNA binding,RNA binding,ATP-dependent DNA helicase activity,protein binding,ATP binding,protein C-terminus binding,transcription regulatory region DNA binding,macromolecular complex binding,5'-deoxyribose-5-phosphate lyase activity,double-stranded telomeric DNA binding nuclear telomere cap complex,nuclear chromosome, telomeric region,extracellular region,nucleus,nucleoplasm,transcription factor complex,nucleolus,cytosol,membrane,secretory granule lumen,Ku70:Ku80 complex,nonhomologous end joining complex,ficolin-1-rich granule lumenl>sp|P12956|XRCC6_HUMAN X-ray repair cross-complementing protein 6 OS=Homo sapiens OX=9606 GN=XRCC6 PE=1 SV=2P05023ATP1A1 AT1A1_HUMAN4Sodium/potassium-transporting ATPase subunit alpha-1Wregulation of the force of heart contraction,regulation of sodium ion transport,cellular sodium ion homeostasis,regulation of blood pressure,potassium ion import,establishment or maintenance of transmembrane electrochemical gradient,dephosphorylation,cellular potassium ion homeostasis,negative regulation of glucocorticoid biosynthetic process,ion transmembrane transport,sodium ion export from cell,response to drug,negative regulation of heart contraction,positive regulation of heart contraction,positive regulation of striated muscle contraction,relaxation of cardiac muscle,membrane hyperpolarization,cellular response to mechanical stimulus,cellular response to steroid hormone stimulus,cardiac muscle cell action potential involved in contraction,regulation of cardiac muscle cell contraction,membrane repolarization,membrane repolarization during cardiac muscle cell action potential,cell communication by electrical coupling involved in cardiac conduction,ATP hydrolysis coupled transmembrane transport,response to glycoside,regulation of cardiac conduction,potassium ion import across plasma membrane< (sodium:potassium-exchanging ATPase activity,protein binding,ATP binding,phosphatase activity,protein kinase binding,protein domain specific binding,ankyrin binding,potassium ion binding,sodium ion binding,ADP binding,phosphatidylinositol 3-kinase binding,chaperone binding,steroid hormone binding\endosome,endoplasmic reticulum,Golgi apparatus,plasma membrane,sodium:potassium-exchanging ATPase complex,caveola,postsynaptic density,intercalated disc,membrane,integral component of membrane,basolateral plasma membrane,apical plasma membrane,T-tubule,sarcolemma,melanosome,myelin sheath,protein complex,extracellular exosome,extracellular vesiclew>sp|P05023|AT1A1_HUMAN Sodium/potassium-transporting ATPase subunit alpha-1 OS=Homo sapiens OX=9606 GN=ATP1A1 PE=1 SV=1P08473MME NEP_HUMAN Neprilysin1kidney development,angiotensin maturation,proteolysis,peptide metabolic process,sensory perception of pain,neutrophil degranulation,creatinine metabolic process,beta-amyloid metabolic process,cellular response to cytokine stimulus,cellular response to UV-A,cellular response to UV-B,replicative senescenceendopeptidase activity,metalloendopeptidase activity,protein binding,metallopeptidase activity,exopeptidase activity,zinc ion binding,peptide bindingcytoplasm,plasma membrane,integral component of plasma membrane,brush border,focal adhesion,synaptic vesicle,integral component of membrane,axon,dendrite,secretory granule membrane,neuron projection terminus,synapse,extracellular exosomeH>sp|P08473|NEP_HUMAN Neprilysin OS=Homo sapiens OX=9606 GN=MME PE=1 SV=2O43854EDIL3 EDIL3_HUMAN@EGF-like repeat and discoidin I-like domain-containing protein 3_cell adhesion,multicellular organism development,positive regulation of cell-substrate adhesion$integrin binding,calcium ion binding@extracellular matrix,extracellular exosome,extracellular vesicle>sp|O43854|EDIL3_HUMAN EGF-like repeat and discoidin I-like domain-containing protein 3 OS=Homo sapiens OX=9606 GN=EDIL3 PE=1 SV=1P50990CCT8 TCPQ_HUMAN!T-complex protein 1 subunit thetaprotein folding,'de novo' protein folding,binding of sperm to zona pellucida,positive regulation of telomere maintenance via telomerase,neutrophil degranulation,pore complex assembly,protein stabilization,chaperone-mediated protein folding,toxin transport,positive regulation of establishment of protein localization to telomere,positive regulation of protein localization to Cajal body,positive regulation of telomerase RNA localization to Cajal bodyprotein binding,ATP binding,ATPase activity, coupled,protein binding involved in protein folding,cadherin binding,unfolded protein binding zona pellucida receptor complex,extracellular region,nucleoplasm,cytoplasm,centrosome,cytosol,chaperonin-containing T-complex,microtubule,cilium,secretory granule lumen,azurophil granule lumen,cell body,intermediate filament cytoskeleton,extracellular exosome,ficolin-1-rich granule lumena>sp|P50990|TCPQ_HUMAN T-complex protein 1 subunit theta OS=Homo sapiens OX=9606 GN=CCT8 PE=1 SV=4P21980TGM2 TGM2_HUMAN-Protein-glutamine gamma-glutamyltransferase 2blood vessel remodeling,isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine,negative regulation of endoplasmic reticulum calcium ion concentration,positive regulation of apoptotic process,positive regulation of I-kappaB kinase/NF-kappaB signaling,apoptotic cell clearance,positive regulation of cell adhesion,positive regulation of smooth muscle cell proliferation,positive regulation of inflammatory response,protein homooligomerization,positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway,positive regulation of mitochondrial calcium ion concentration,branching involved in salivary gland morphogenesis,salivary gland cavitationprotein-glutamine gamma-glutamyltransferase activity,protein binding,GTP binding,protein domain specific binding,metal ion bindingmitochondrion,endoplasmic reticulum,cytosol,focal adhesion,extracellular matrix,intrinsic component of plasma membrane,extracellular exosomem>sp|P21980|TGM2_HUMAN Protein-glutamine gamma-glutamyltransferase 2 OS=Homo sapiens OX=9606 GN=TGM2 PE=1 SV=2P22314UBA1 UBA1_HUMAN+Ubiquitin-like modifier-activating enzyme 1?cellular response to DNA damage stimulus,protein ubiquitinationLRNA binding,ubiquitin activating enzyme activity,protein binding,ATP bindingnucleus,nucleoplasm,cytoplasm,mitochondrion,cytosol,extracellular exosome,heterochromatin,lysosomal membrane,endosome membrane,desmosome,rough endoplasmic reticulum membranek>sp|P22314|UBA1_HUMAN Ubiquitin-like modifier-activating enzyme 1 OS=Homo sapiens OX=9606 GN=UBA1 PE=1 SV=3P21399ACO1 ACOC_HUMANCytoplasmic aconitate hydratasetricarboxylic acid cycle,citrate metabolic process,regulation of translation,cellular iron ion homeostasis,post-embryonic development,response to iron(II) ion,intestinal absorptionRNA binding,aconitate hydratase activity,protein binding,iron-responsive element binding,metal ion binding,4 iron, 4 sulfur cluster binding[cytoplasm,mitochondrion,endoplasmic reticulum,Golgi apparatus,cytosol,extracellular exosome_>sp|P21399|ACOC_HUMAN Cytoplasmic aconitate hydratase OS=Homo sapiens OX=9606 GN=ACO1 PE=1 SV=3P17987TCP1 TCPA_HUMAN!T-complex protein 1 subunit alphadprotein folding,'de novo' protein folding,tubulin complex assembly,binding of sperm to zona pellucida,positive regulation of telomere maintenance via telomerase,translocation of peptides or proteins into host cell cytoplasm,protein stabilization,positive regulation of telomerase activity,chaperone-mediated protein folding,scaRNA localization to Cajal body,toxin transport,positive regulation of establishment of protein localization to telomere,positive regulation of protein localization to Cajal body,positive regulation of telomerase RNA localization to Cajal body,regulation of macrophage apoptotic processRNA binding,protein binding,ATP binding,ubiquitin protein ligase binding,protein binding involved in protein folding,unfolded protein bindingpericentriolar material,acrosomal vesicle,zona pellucida receptor complex,nuclear heterochromatin,Golgi apparatus,centrosome,cytosol,chaperonin-containing T-complex,microtubule,myelin sheath,cell body,extracellular exosomea>sp|P17987|TCPA_HUMAN T-complex protein 1 subunit alpha OS=Homo sapiens OX=9606 GN=TCP1 PE=1 SV=1P11142HSPA8 HSP7C_HUMAN!Heat shock cognate 71 kDa protein2mRNA splicing, via spliceosome,transcription, DNA-templated,protein folding,protein methylation,response to unfolded protein,neurotransmitter secretion,cellular response to starvation,viral process,regulation of protein stability,protein refolding,regulation of protein complex assembly,neutrophil degranulation,regulation of mRNA stability,positive regulation by host of viral genome replication,negative regulation of transcription, DNA-templated,ATP metabolic process,positive regulation of mRNA splicing, via spliceosome,chaperone mediated protein folding requiring cofactor,regulation of cell cycle,membrane organization,regulation of protein complex stability,chaperone-mediated autophagy,late endosomal microautophagy,protein targeting to lysosome involved in chaperone-mediated autophagy,chaperone-mediated protein transport involved in chaperone-mediated autophagy,clathrin coat disassembly,regulation of cellular response to heat,negative regulation of fibril organization,regulation of protein import,chaperone-mediated autophagy translocation complex disassemblyNG-protein coupled receptor binding,phosphatidylserine binding,RNA binding,protein binding,ATP binding,ATPase activity,enzyme binding,MHC class II protein complex binding,heat shock protein binding,ubiquitin protein ligase binding,ATPase activity, coupled,cadherin binding,unfolded protein binding,C3HC4-type RING finger domain bindingPrp19 complex,extracellular region,extracellular space,intracellular,nucleus,nucleoplasm,spliceosomal complex,nucleolus,lysosomal membrane,late endosome,cytosol,plasma membrane,focal adhesion,membrane,intracellular ribonucleoprotein complex,extrace< llular matrix,secretory granule lumen,melanosome,lysosomal lumen,myelin sheath,clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane,extracellular exosome,blood microparticle,lumenal side of lysosomal membrane,presynapse,ficolin-1-rich granule lumen,ubiquitin ligase complexc>sp|P11142|HSP7C_HUMAN Heat shock cognate 71 kDa protein OS=Homo sapiens OX=9606 GN=HSPA8 PE=1 SV=1P23634ATP2B4 AT2B4_HUMAN-Plasma membrane calcium-transporting ATPase 4neural retina development,regulation of transcription from RNA polymerase II promoter,cellular calcium ion homeostasis,spermatogenesis,negative regulation of nitric oxide mediated signal transduction,hippocampus development,flagellated sperm motility,positive regulation of peptidyl-serine phosphorylation,ion transmembrane transport,negative regulation of nitric oxide biosynthetic process,negative regulation of nitric-oxide synthase activity,response to hydrostatic pressure,calcium ion transmembrane transport,negative regulation of calcineurin-NFAT signaling cascade,cellular response to epinephrine stimulus,calcium ion transmembrane import into cytosol,calcium ion import across plasma membrane,negative regulation of the force of heart contraction,Requires Ontology,negative regulation of arginine catabolic process,negative regulation of adrenergic receptor signaling pathway involved in heart process,calcium ion export,negative regulation of peptidyl-cysteine S-nitrosylation,regulation of sodium ion transmembrane transport,regulation of cell cycle G1/S phase transition,negative regulation of cardiac muscle hypertrophy in response to stress,negative regulation of citrulline biosynthetic process,regulation of cardiac conduction,positive regulation of cAMP-dependent protein kinase activity0calcium-transporting ATPase activity,protein binding,calmodulin binding,ATP binding,protein kinase binding,PDZ domain binding,protein phosphatase 2B binding,nitric-oxide synthase inhibitor activity,metal ion binding,nitric-oxide synthase binding,scaffold protein binding,sodium channel regulator activityplasma membrane,integral component of plasma membrane,caveola,membrane,basolateral plasma membrane,Z disc,T-tubule,sperm flagellum,neuron projection,intracellular membrane-bounded organelle,protein complex,sperm principal piecep>sp|P23634|AT2B4_HUMAN Plasma membrane calcium-transporting ATPase 4 OS=Homo sapiens OX=9606 GN=ATP2B4 PE=1 SV=2P02545LMNA LMNA_HUMAN Prelamin-A/Czmitotic nuclear envelope disassembly,mitotic nuclear envelope reassembly,regulation of cell migration,establishment or maintenance of microtubule cytoskeleton polarity,protein localization to nucleus,sterol regulatory element binding protein import into nucleus,IRE1-mediated unfolded protein response,ventricular cardiac muscle cell development,cellular response to hypoxia,negative regulation of mesenchymal cell proliferation,negative regulation of release of cytochrome c from mitochondria,positive regulation of cell aging,regulation of protein localization to nucleus,negative regulation of extrinsic apoptotic signaling pathwayonucleus,nuclear envelope,lamin filament,nucleoplasm,cytosol,nuclear speck,extracellular matrix,nuclear membraneL>sp|P02545|LMNA_HUMAN Prelamin-A/C OS=Homo sapiens OX=9606 GN=LMNA PE=1 SV=1Q9NR99MXRA5 MXRA5_HUMAN&Matrix-remodeling-associated protein 5h>sp|Q9NR99|MXRA5_HUMAN Matrix-remodeling-associated protein 5 OS=Homo sapiens OX=9606 GN=MXRA5 PE=1 SV=3P41252IARS1 SYIC_HUMAN$Isoleucine--tRNA ligase, cytoplasmicosteoblast differentiation,tRNA aminoacylation for protein translation,isoleucyl-tRNA aminoacylation,regulation of translational fidelitywtRNA binding,aminoacyl-tRNA editing activity,isoleucine-tRNA ligase activity,protein binding,ATP binding,GTPase bindinge>sp|P41252|SYIC_HUMAN Isoleucine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=IARS1 PE=1 SV=2P21589NT5E 5NTD_HUMAN5'-nucleotidasepurine nucleotide catabolic process,AMP catabolic process,DNA metabolic process,leukocyte cell-cell adhesion,dephosphorylation,NAD metabolic process,adenosine biosynthetic process,pyrimidine nucleoside catabolic process,negative regulation of inflammatory response=nucleotide binding,5'-nucleotidase activity,metal ion bindingbcytosol,plasma membrane,cell surface,membrane,anchored component of membrane,extracellular exosomeO>sp|P21589|5NTD_HUMAN 5'-nucleotidase OS=Homo sapiens OX=9606 GN=NT5E PE=1 SV=1Q06210GFPT1 GFPT1_HUMAN@Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1fructose 6-phosphate metabolic process,UDP-N-acetylglucosamine biosynthetic process,energy reserve metabolic process,glutamine metabolic process,circadian regulation of gene expression,IRE1-mediated unfolded protein responsebglutamine-fructose-6-phosphate transaminase (isomerizing) activity,carbohydrate derivative binding>sp|Q06210|GFPT1_HUMAN Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 OS=Homo sapiens OX=9606 GN=GFPT1 PE=1 SV=3P78371CCT2 TCPB_HUMAN T-complex protein 1 subunit beta$protein folding,binding of sperm to zona pellucida,positive regulation of telomere maintenance via telomerase,neutrophil degranulation,protein stabilization,chaperone mediated protein folding independent of cofactor,chaperone-mediated protein complex assembly,positive regulation of telomerase activity,scaRNA localization to Cajal body,toxin transport,positive regulation of establishment of protein localization to telomere,positive regulation of protein localization to Cajal body,positive regulation of telomerase RNA localization to Cajal bodyprotein binding,ATP binding,ubiquitin protein ligase binding,protein binding involved in protein folding,unfolded protein bindingzona pellucida receptor complex,extracellular region,cytosol,chaperonin-containing T-complex,microtubule,extracellular matrix,azurophil granule lumen,myelin sheath,cell body,extracellular exosome`>sp|P78371|TCPB_HUMAN T-complex protein 1 subunit beta OS=Homo sapiens OX=9606 GN=CCT2 PE=1 SV=4O00159MYO1C MYO1C_HUMANUnconventional myosin-IcVprotein targeting,protein targeting to membrane,positive regulation of cell migration,positive regulation of actin filament polymerization,positive regulation of cell migration by vascular endothelial growth factor signaling pathway,Fc-gamma receptor signaling pathway involved in phagocytosis,positive regulation of gene expression, epigenetic,mRNA transport,positive regulation of protein targeting to membrane,positive regulation of cellular response to insulin stimulus,positive regulation of vascular endothelial growth factor signaling pathway,regulation of bicellular tight junction assemblymicrofilament motor activity,receptor binding,protein binding,calmodulin binding,ATP binding,protein C-terminus binding,Ral GTPase binding,actin-dependent ATPase activity,actin filament bindingMnuclear pore,nucleoplasm,nucleolus,cytoplasm,cytosol,plasma membrane,microvillus,brush border,basal plasma membrane,membrane,lateral plasma membrane,unconventional myosin complex,nuclear body,cytoplasmic vesicle,filamentous actin,ruffle membrane,membrane raft,myosin I complex,stereocilium membrane,extracellular exosome,stress fiberZ>sp|O00159|MYO1C_HUMAN Unconventional myosin-Ic OS=Homo sapiens OX=9606 GN=MYO1C PE=1 SV=4Q14980NUMA1 NUMA1_HUMAN#Nuclear mitotic apparatus protein 1establishment of mitotic spindle orientation,nucleus organization,mitotic nuclear division,cell division,meiotic cell cycle,lung epithelial cell differentiationGolgi membrane,spindle pole,nucleus,nucleoplasm,chromosome,centrosome,spindle,cytosol,spindle microtubule,cell cortex,nuclear matrix,dendrite,neuronal cell body,apical part of cell,mitotic spindle astral microtubule,extracellular exosome,mitotic spindle,mitotic spindle polee>sp|Q14980|NUMA1_HUMAN Nuclear mitotic apparatus protein 1 OS=Homo sapiens OX=9606 GN=NUMA1 PE=1 SV=2P13639EEF2 EF2_HUMANElongation factor 2Uhematopoietic progenitor cell differentiation,response to ischemia,skeletal muscle contraction,translational elongation,protein methylation,aging,glial cell proliferation,peptidyl-diphthamide< biosynthetic process from peptidyl-histidine,response to estradiol,response to endoplasmic reticulum stress,skeletal muscle cell differentiation,response to drug,response to hydrogen peroxide,neutrophil degranulation,response to ethanol,positive regulation of translation,response to folic acid,cellular response to brain-derived neurotrophic factor stimulus,positive regulation of cytoplasmic translationp53 binding,RNA binding,translation elongation factor activity,GTPase activity,protein binding,GTP binding,5S rRNA binding,protein kinase binding,ribosome binding,cadherin binding,actin filament bindingextracellular region,nucleus,cytoplasm,cytosol,plasma membrane,membrane,aggresome,intracellular ribonucleoprotein complex,extracellular matrix,secretory granule lumen,polysomal ribosome,membrane raft,extracellular exosome,ficolin-1-rich granule lumenR>sp|P13639|EF2_HUMAN Elongation factor 2 OS=Homo sapiens OX=9606 GN=EEF2 PE=1 SV=4P48643CCT5 TCPE_HUMAN#T-complex protein 1 subunit epsilonprotein folding,'de novo' protein folding,binding of sperm to zona pellucida,response to virus,positive regulation of telomere maintenance via telomerase,protein stabilization,chaperone-mediated protein folding,toxin transport,positive regulation of establishment of protein localization to telomere,positive regulation of protein localization to Cajal body,positive regulation of telomerase RNA localization to Cajal bodyprotein binding,ATP binding,G-protein beta-subunit binding,protein binding involved in protein folding,beta-tubulin binding,unfolded protein bindingzona pellucida receptor complex,nucleolus,centrosome,cytosol,chaperonin-containing T-complex,microtubule,myelin sheath,cell body,extracellular exosomec>sp|P48643|TCPE_HUMAN T-complex protein 1 subunit epsilon OS=Homo sapiens OX=9606 GN=CCT5 PE=1 SV=1P02461COL3A1 CO3A1_HUMANCollagen alpha-1(III) chainskeletal system development,cell-matrix adhesion,transforming growth factor beta receptor signaling pathway,integrin-mediated signaling pathway,heart development,aging,response to radiation,response to mechanical stimulus,peptide cross-linking,cerebral cortex development,platelet activation,extracellular matrix organization,collagen fibril organization,collagen catabolic process,response to cytokine,positive regulation of Rho protein signal transduction,wound healing,skin development,digestive tract development,regulation of immune response,negative regulation of immune response,aorta smooth muscle tissue morphogenesis,cellular response to amino acid stimulus,fibril organization,negative regulation of neuron migrationintegrin binding,extracellular matrix structural constituent,protein binding,SMAD binding,metal ion binding,platelet-derived growth factor bindingrextracellular region,collagen type III trimer,extracellular space,endoplasmic reticulum lumen,extracellular matrix^>sp|P02461|CO3A1_HUMAN Collagen alpha-1(III) chain OS=Homo sapiens OX=9606 GN=COL3A1 PE=1 SV=4P07355ANXA2 ANXA2_HUMAN Annexin A2Sangiogenesis,membrane raft assembly,positive regulation of receptor recycling,positive regulation of protein phosphorylation,membrane budding,body fluid secretion,collagen fibril organization,positive regulation of vesicle fusion,negative regulation of low-density lipoprotein particle receptor catabolic process,osteoclast development,fibrinolysis,negative regulation of catalytic activity,neutrophil degranulation,positive regulation of fibroblast proliferation,protein heterotetramerization,protein targeting to plasma membrane,response to thyroid hormone,cell-cell adhesion,Requires Ontologylprotease binding,RNA binding,calcium ion binding,protein binding,calcium-dependent phospholipid binding,phosphatidylinositol-4,5-bisphosphate binding,cytoskeletal protein binding,Rab GTPase binding,phospholipase A2 inhibitor activity,S100 protein binding,calcium-dependent protein binding,cadherin binding involved in cell-cell adhesion,receptor activator activity%ruffle,extracellular region,basement membrane,extracellular space,nucleus,lysosomal membrane,endosome,early endosome,lipid particle,cytosol,plasma membrane,cell-cell adherens junction,cell cortex,cell surface,membrane,basolateral plasma membrane,extrinsic component of plasma membrane,midbody,late endosome membrane,vesicle,azurophil granule lumen,myelin sheath adaxonal region,sarcolemma,melanosome,Schmidt-Lanterman incisure,macropinosome,perinuclear region of cytoplasm,extracellular exosome,PCSK9-AnxA2 complex,extracellular matrix,membrane raftL>sp|P07355|ANXA2_HUMAN Annexin A2 OS=Homo sapiens OX=9606 GN=ANXA2 PE=1 SV=2P02533KRT14 K1C14_HUMANKeratin, type I cytoskeletal 14aging,epidermis development,response to zinc ion,response to ionizing radiation,keratinization,hemidesmosome assembly,hair cycle,intermediate filament bundle assembly,cornificationOstructural constituent of cytoskeleton,protein binding,keratin filament bindingxnucleus,cytoplasm,cytosol,intermediate filament,keratin filament,basal part of cell,extracellular exosome,cell peripherya>sp|P02533|K1C14_HUMAN Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4Q15063POSTN POSTN_HUMAN Periostinskeletal system development,response to hypoxia,negative regulation of cell-matrix adhesion,regulation of systemic arterial blood pressure,cell adhesion,regulation of Notch signaling pathway,response to mechanical stimulus,response to muscle activity,positive regulation of smooth muscle cell migration,extracellular matrix organization,response to estradiol,cellular response to fibroblast growth factor stimulus,cellular response to vitamin K,cellular response to tumor necrosis factor,cellular response to transforming growth factor beta stimulus,negative regulation of substrate adhesion-dependent cell spreading,positive regulation of chemokine (C-C motif) ligand 2 secretion,neuron projection extension,bone regeneration1protein binding,heparin binding,metal ion bindingvproteinaceous extracellular matrix,extracellular space,trans-Golgi network,extracellular matrix,neuromuscular junctionK>sp|Q15063|POSTN_HUMAN Periostin OS=Homo sapiens OX=9606 GN=POSTN PE=1 SV=2P26038MSN MOES_HUMANMoesinmovement of cell or subcellular component,cytoskeleton organization,leukocyte cell-cell adhesion,regulation of cell shape,regulation of cell size,positive regulation of gene expression,gland morphogenesis,membrane to membrane docking,establishment of epithelial cell apical/basal polarity,leukocyte migration,establishment of endothelial barrier,cellular response to testosterone stimulus,positive regulation of podosome assembly,regulation of organelle assembly,positive regulation of protein localization to early endosome,positive regulation of cellular protein catabolic process,regulation of lymphocyte migration,positive regulation of early endosome to late endosome transportdouble-stranded RNA binding,actin binding,receptor binding,structural constituent of cytoskeleton,protein binding,protein kinase binding,cell adhesion molecule bindingouropod,extracellular space,nucleus,cytoplasm,cytosol,cytoskeleton,plasma membrane,microvillus,focal adhesion,basolateral plasma membrane,apical plasma membrane,extrinsic component of membrane,filopodium,pseudopodium,microvillus membrane,vesicle,myelin sheath,apical part of cell,perinuclear region of cytoplasm,extracellular exosome,cell periphery,blood microparticleE>sp|P26038|MOES_HUMAN Moesin OS=Homo sapiens OX=9606 GN=MSN PE=1 SV=3P29144TPP2 TPP2_HUMANTripeptidyl-peptidase 2&protein polyubiquitination,proteolysisendopeptidase activity,aminopeptidase activity,serine-type endopeptidase activity,protein binding,tripeptidyl-peptidase activity*nucleoplasm,cytoplasm,cytosol,nuclear bodyW>sp|P29144|TPP2_HUMAN Tripeptidyl-peptidase 2 OS=Homo sapiens OX=9606 GN=TPP2 PE=1 SV=4P48681NES NEST_HUMANNestinG2/M transition of mitotic cell cycle,central nervous system development,brain development,positive regulation of intermediate filament depolymerization,embryonic camera-type eye development,negative regulation of protein binding,negative regulation of catalytic activi< ty,negative regulation of neuron apoptotic process,cell projection morphogenesis,stem cell proliferation,positive regulation of neural precursor cell proliferationMmolecular_function,structural molecule activity,intermediate filament bindingWcytoplasm,intermediate filament,extracellular matrix,intermediate filament cytoskeletonE>sp|P48681|NEST_HUMAN Nestin OS=Homo sapiens OX=9606 GN=NES PE=1 SV=2P08238HSP90AB1 HS90B_HUMANHeat shock protein HSP 90-betaplacenta development,protein folding,xenobiotic metabolic process,response to unfolded protein,telomere maintenance via telomerase,response to salt stress,virion attachment to host cell,positive regulation of transforming growth factor beta receptor signaling pathway,regulation of protein ubiquitination,positive regulation of protein binding,negative regulation of proteasomal ubiquitin-dependent protein catabolic process,positive regulation of phosphoprotein phosphatase activity,positive regulation of protein import into nucleus, translocation,cellular response to drug,Fc-gamma receptor signaling pathway involved in phagocytosis,response to cocaine,neutrophil degranulation,negative regulation of neuron apoptotic process,positive regulation of nitric oxide biosynthetic process,positive regulation of cell differentiation,positive regulation of cell size,protein stabilization,positive regulation of telomerase activity,regulation of interferon-gamma-mediated signaling pathway,regulation of type I interferon-mediated signaling pathway,negative regulation of cell cycle arrest,cellular response to interleukin-4,cellular response to organic cyclic compound,positive regulation of protein serine/threonine kinase activity,fibril organization,regulation of cellular response to heat,negative regulation of complement-dependent cytotoxicity,telomerase holoenzyme complex assembly,positive regulation of protein localization to cell surface)glycoprotein binding,UTP binding,CTP binding,RNA binding,double-stranded RNA binding,protein binding,ATP binding,GTP binding,drug binding,sulfonylurea receptor binding,protein kinase regulator activity,kinase binding,protein kinase binding,MHC class II protein complex binding,nitric-oxide synthase regulator activity,TPR domain binding,heat shock protein binding,dATP binding,histone deacetylase binding,ion channel binding,cadherin binding,protein dimerization activity,unfolded protein binding,DNA polymerase binding,histone methyltransferase bindinguextracellular region,nucleus,nucleoplasm,cytoplasm,mitochondrion,lysosomal membrane,cytosol,cell surface,membrane,inclusion body,basolateral plasma membrane,apical plasma membrane,brush border membrane,aryl hydrocarbon receptor complex,secretory granule lumen,melanosome,extracellular exosome,ficolin-1-rich granule lumen,sperm head plasma membrane,ooplasm,COP9 signalosomec>sp|P08238|HS90B_HUMAN Heat shock protein HSP 90-beta OS=Homo sapiens OX=9606 GN=HSP90AB1 PE=1 SV=4P15144ANPEP AMPN_HUMANAminopeptidase Nangiogenesis,proteolysis,signal transduction,cell-cell signaling,regulation of blood pressure,cell differentiation,peptide catabolic process,neutrophil degranulation,viral entry into host cellvirus receptor activity,aminopeptidase activity,receptor activity,metallopeptidase activity,zinc ion binding,peptide binding,metalloaminopeptidase activityextracellular space,nucleus,lysosomal membrane,endoplasmic reticulum-Golgi intermediate compartment,cytosol,plasma membrane,external side of plasma membrane,integral component of membrane,secretory granule membrane,extracellular exosomeQ>sp|P15144|AMPN_HUMAN Aminopeptidase N OS=Homo sapiens OX=9606 GN=ANPEP PE=1 SV=4P01024C3 CO3_HUMAN Complement C3positive regulation of type IIa hypersensitivity,positive regulation of protein phosphorylation,positive regulation of activation of membrane attack complex,proteolysis,fatty acid metabolic process,inflammatory response,immune response,complement activation,complement activation, alternative pathway,complement activation, classical pathway,signal transduction,G-protein coupled receptor signaling pathway,positive regulation of vascular endothelial growth factor production,positive regulation of glucose transport,regulation of triglyceride biosynthetic process,positive regulation of lipid storage,negative regulation of endopeptidase activity,regulation of complement activation,neutrophil degranulation,positive regulation of G-protein coupled receptor protein signaling pathway,positive regulation of angiogenesis,regulation of immune response,positive regulation of apoptotic cell clearanceserine-type endopeptidase activity,endopeptidase inhibitor activity,receptor binding,protein binding,C5L2 anaphylatoxin chemotactic receptor bindingextracellular region,extracellular space,plasma membrane,secretory granule lumen,azurophil granule lumen,extracellular exosome,blood microparticleJ>sp|P01024|CO3_HUMAN Complement C3 OS=Homo sapiens OX=9606 GN=C3 PE=1 SV=2P17301ITGA2 ITA2_HUMANIntegrin alpha-2response to hypoxia,positive regulation of leukocyte migration,substrate-dependent cell migration,hypotonic response,cell adhesion,cell-matrix adhesion,integrin-mediated signaling pathway,female pregnancy,blood coagulation,cell proliferation,animal organ morphogenesis,positive regulation of epithelial cell migration,positive regulation of alkaline phosphatase activity,response to amine,response to muscle activity,positive regulation of smooth muscle cell migration,extracellular matrix organization,mammary gland development,positive regulation of cell projection organization,cell-substrate adhesion,positive regulation of collagen biosynthetic process,positive regulation of collagen binding,response to L-ascorbic acid,cell adhesion mediated by integrin,collagen-activated signaling pathway,response to drug,positive regulation of DNA binding,skin morphogenesis,establishment of protein localization,positive regulation of translation,positive regulation of cell adhesion,positive regulation of smooth muscle contraction,viral entry into host cell,focal adhesion assembly,mesodermal cell differentiation,positive regulation of smooth muscle cell proliferation,positive regulation of inflammatory response,positive regulation of positive chemotaxis,detection of mechanical stimulus involved in sensory perception of pain,positive regulation of transmission of nerve impulse,positive regulation of phagocytosis, engulfment,hepatocyte differentiation,response to parathyroid hormone,cellular response to mechanical stimulus,cellular response to estradiol stimulusvirus receptor activity,integrin binding,protein binding,collagen binding,protein complex binding,collagen receptor activity,laminin binding,metal ion binding,protein heterodimerization activity,collagen binding involved in cell-matrix adhesionnucleus,plasma membrane,focal adhesion,integrin complex,external side of plasma membrane,cell surface,axon,integrin alpha2-beta1 complex,axon terminus,basal part of cell,perinuclear region of cytoplasmQ>sp|P17301|ITA2_HUMAN Integrin alpha-2 OS=Homo sapiens OX=9606 GN=ITGA2 PE=1 SV=1Q13200PSMD2 PSMD2_HUMAN.26S proteasome non-ATPase regulatory subunit 2proteasome complex,extracellular region,nucleoplasm,cytosol,proteasome regulatory particle,membrane,proteasome accessory complex,secretory granule lumen,extracellular exosome,ficolin-1-rich granule lumenp>sp|Q13200|PSMD2_HUMAN 26S proteasome non-ATPase regulatory subunit 2 OS=Homo sapiens OX=9606 GN=PSMD2 PE=1 SV=3O00391QSOX1 QSOX1_HUMANSulfhydryl oxidase 1platelet degranulation,negative regulation of macroautophagy,neutrophil degranulation,cell redox homeostasis,oxidation-reduction processNprotein disulfide isomerase activity,flavin-linked sulfhydryl oxidase activityextracellular region,extracellular space,Golgi apparatus,integral component of Golgi membrane,platelet alpha granule lumen,specific granule lumen,intracellular membrane-bounded organelle,intercellular bridge,extracellular exosome,tertiary granule lumenV>sp|O00391|QSOX1_HUMAN Sulfhydryl oxidase 1 OS=Homo sapiens OX=9606 GN=QSOX1 PE=1 SV=3Q15582TGFBI BGH3_HUMAN5Transforming grow< th factor-beta-induced protein ig-h3angiogenesis,chondrocyte differentiation,cell adhesion,negative regulation of cell adhesion,visual perception,cell proliferation,extracellular matrix organization,cellular protein metabolic process,response to stimulusNintegrin binding,protein binding,collagen binding,extracellular matrix bindingextracellular region,basement membrane,extracellular space,trans-Golgi network,plasma membrane,extracellular matrix,extracellular exosomev>sp|Q15582|BGH3_HUMAN Transforming growth factor-beta-induced protein ig-h3 OS=Homo sapiens OX=9606 GN=TGFBI PE=1 SV=1P14618PKM KPYM_HUMANPyruvate kinase PKMiprogrammed cell death,cellular response to insulin stimulus,neutrophil degranulation,canonical glycolysismagnesium ion binding,RNA binding,pyruvate kinase activity,protein binding,ATP binding,kinase activity,MHC class II protein complex binding,potassium ion binding,cadherin bindingextracellular region,nucleus,cytoplasm,mitochondrion,cytosol,cilium,extracellular matrix,vesicle,secretory granule lumen,myelin sheath,extracellular exosome,extracellular vesicle,ficolin-1-rich granule lumenR>sp|P14618|KPYM_HUMAN Pyruvate kinase PKM OS=Homo sapiens OX=9606 GN=PKM PE=1 SV=4P53621COPA COPA_HUMANCoatomer subunit alphaintracellular protein transport,ER to Golgi vesicle-mediated transport,retrograde vesicle-mediated transport, Golgi to ER,intra-Golgi vesicle-mediated transport,pancreatic juice secretion-hormone activity,structural molecule activityGolgi membrane,extracellular space,cytoplasm,endoplasmic reticulum membrane,cytosol,membrane,COPI vesicle coat,transport vesicle,extracellular exosomeV>sp|P53621|COPA_HUMAN Coatomer subunit alpha OS=Homo sapiens OX=9606 GN=COPA PE=1 SV=2P13645KRT10 K1C10_HUMANKeratin, type I cytoskeletal 109keratinocyte differentiation,keratinization,cornification#structural constituent of epidermisbextracellular space,nucleus,cytoplasm,cytosol,intermediate filament,membrane,extracellular exosomea>sp|P13645|K1C10_HUMAN Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6P04259KRT6B K2C6B_HUMAN Keratin, type II cytoskeletal 6BKcytoskeleton organization,ectoderm development,keratinization,cornification.cytosol,keratin filament,extracellular exosomeb>sp|P04259|K2C6B_HUMAN Keratin, type II cytoskeletal 6B OS=Homo sapiens OX=9606 GN=KRT6B PE=1 SV=5Q02809PLOD1 PLOD1_HUMAN1Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1response to hypoxia,cellular protein modification process,epidermis development,hydroxylysine biosynthetic process,oxidation-reduction processtiron ion binding,procollagen-lysine 5-dioxygenase activity,L-ascorbic acid binding,protein homodimerization activitys>sp|Q02809|PLOD1_HUMAN Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 OS=Homo sapiens OX=9606 GN=PLOD1 PE=1 SV=2Q5T4S7UBR4 UBR4_HUMAN E3 ubiquitin-protein ligase UBR4wviral process,protein ubiquitination involved in ubiquitin-dependent protein catabolic process,neutrophil degranulationZubiquitin-protein transferase activity,protein binding,calmodulin binding,zinc ion bindingnucleoplasm,centrosome,cytosol,plasma membrane,membrane,integral component of membrane,specific granule membrane,tertiary granule membrane,ficolin-1-rich granule membrane`>sp|Q5T4S7|UBR4_HUMAN E3 ubiquitin-protein ligase UBR4 OS=Homo sapiens OX=9606 GN=UBR4 PE=1 SV=1P33176KIF5B KINH_HUMANKinesin-1 heavy chainmicrotubule-based movement,cytoplasm organization,axon guidance,cytoskeleton-dependent intracellular transport,positive regulation of vesicle fusion,positive regulation of synaptic transmission, GABAergic,stress granule disassembly,positive regulation of insulin secretion involved in cellular response to glucose stimulus,regulation of membrane potential,positive regulation of potassium ion transport,vesicle transport along microtubule,centrosome localization,plus-end-directed vesicle transport along microtubule,positive regulation of establishment of protein localization to plasma membrane,positive regulation of intracellular protein transport,positive regulation of voltage-gated sodium channel activitymicrotubule motor activity,protein binding,ATP binding,microtubule binding,JUN kinase binding,ATP-dependent microtubule motor activity, plus-end-directed,cadherin bindingmicrotubule organizing center,cytosol,kinesin complex,microtubule,membrane,endocytic vesicle,vesicle,ciliary rootlet,axonal growth cone,perinuclear region of cytoplasmV>sp|P33176|KINH_HUMAN Kinesin-1 heavy chain OS=Homo sapiens OX=9606 GN=KIF5B PE=1 SV=1P08670VIM VIME_HUMANVimentinEmovement of cell or subcellular component,positive regulation of gene expression,negative regulation of neuron projection development,astrocyte development,viral process,muscle filament sliding,intermediate filament organization,Bergmann glial cell differentiation,SMAD protein signal transduction,lens fiber cell developmentglycoprotein binding,double-stranded RNA binding,structural constituent of cytoskeleton,structural constituent of eye lens,protein binding,protein C-terminus binding,identical protein binding,scaffold protein binding,keratin filament bindingcytoplasm,peroxisome,cytosol,cytoskeleton,intermediate filament,focal adhesion,extracellular matrix,cell leading edge,neuron projection,extracellular exosome,plasma membraneG>sp|P08670|VIME_HUMAN Vimentin OS=Homo sapiens OX=9606 GN=VIM PE=1 SV=4P13611VCAN CSPG2_HUMANVersican core proteinVskeletal system development,osteoblast differentiation,cell adhesion,multicellular organism development,central nervous system development,cell recognition,extracellular matrix organization,glycosaminoglycan metabolic process,chondroitin sulfate biosynthetic process,chondroitin sulfate catabolic process,dermatan sulfate biosynthetic processextracellular matrix structural constituent,calcium ion binding,protein binding,glycosaminoglycan binding,hyaluronic acid binding,carbohydrate bindingextracellular region,proteinaceous extracellular matrix,extracellular space,Golgi lumen,membrane,extracellular matrix,lysosomal lumenV>sp|P13611|CSPG2_HUMAN Versican core protein OS=Homo sapiens OX=9606 GN=VCAN PE=1 SV=3O43707ACTN4 ACTN4_HUMANAlpha-actinin-4response to hypoxia,platelet degranulation,protein transport,vesicle transport along actin filament,positive regulation of cell migration,positive regulation of sodium:proton antiporter activity,peroxisome proliferator activated receptor signaling pathway,regulation of apoptotic process,retinoic acid receptor signaling pathway,positive regulation of pinocytosis,actin filament bundle assembly,negative regulation of cellular component movement,positive regulation of cellular component movement,bicellular tight junction assembly,negative regulation of substrate adhesion-dependent cell spreading,positive regulation of NIK/NF-kappaB signaling,protein localization to bicellular tight junction,regulation of nucleic acid-templated transcriptionRNA polymerase II regulatory region sequence-specific DNA binding,nucleoside binding,RNA binding,actin binding,integrin binding,calcium ion binding,protein binding,ligand-dependent nuclear receptor transcription coactivator activity,chromatin DNA binding,nuclear hormone receptor binding,protein homodimerization activity,retinoic acid receptor binding,ion channel binding,protein N-terminus binding,actin filament bindingsstress fiber,extracellular region,extracellular space,intracellular,nucleus,cytoplasm,cytosol,brush border,cell-cell junction,focal adhesion,nuclear body,Z disc,intracellular ribonucleoprotein complex,cortical cytoskeleton,platelet alpha granule lumen,pseudopodium,neuron projection,protein complex,perinuclear region of cytoplasm,extracellular exosome,actin cytoskeletonQ>sp|O43707|ACTN4_HUMAN Alpha-actinin-4 OS=Homo sapiens OX=9606 GN=ACTN4 PE=1 SV=2Q13219PAPPA PAPP1_HUMAN Pappalysin-1proteolysis,female pregnancy,response to follicle-stimulating hormone,cellular protein metabolic process,response to glucocorticoidHmetalloendopeptidase activity,metallopeptidase activity,zinc ion binding< N>sp|Q13219|PAPP1_HUMAN Pappalysin-1 OS=Homo sapiens OX=9606 GN=PAPPA PE=1 SV=3Q14112NID2 NID2_HUMAN Nidogen-2ccell adhesion,cell-matrix adhesion,extracellular matrix organization,basement membrane organization4calcium ion binding,protein binding,collagen bindinguextracellular region,basement membrane,extracellular space,plasma membrane,extracellular matrix,extracellular exosomeI>sp|Q14112|NID2_HUMAN Nidogen-2 OS=Homo sapiens OX=9606 GN=NID2 PE=1 SV=3P18206VCL VINC_HUMANVinculinmorphogenesis of an epithelium,platelet degranulation,movement of cell or subcellular component,muscle contraction,cell adhesion,cell-matrix adhesion,lamellipodium assembly,negative regulation of cell migration,adherens junction assembly,protein localization to cell surface,apical junction assembly,neutrophil degranulation,axon extension,platelet aggregation,epithelial cell-cell adhesiondystroglycan binding,actin binding,structural molecule activity,protein binding,beta-catenin binding,ubiquitin protein ligase binding,alpha-catenin binding,cadherin bindingLpodosome,extracellular region,cytosol,cytoskeleton,plasma membrane,cell-cell junction,adherens junction,cell-cell adherens junction,fascia adherens,focal adhesion,cell-substrate junction,secretory granule lumen,specific granule lumen,costamere,protein complex,extracellular exosome,extracellular vesicle,ficolin-1-rich granule lumenG>sp|P18206|VINC_HUMAN Vinculin OS=Homo sapiens OX=9606 GN=VCL PE=1 SV=4Q9Y6C2EMILIN1 EMIL1_HUMANEMILIN-1 cell adhesion`protein binding,extracellular matrix constituent conferring elasticity,identical protein bindingextracellular region,proteinaceous extracellular matrix,collagen trimer,extracellular space,extracellular matrix,extracellular exosomeL>sp|Q9Y6C2|EMIL1_HUMAN EMILIN-1 OS=Homo sapiens OX=9606 GN=EMILIN1 PE=1 SV=3P35556FBN2 FBN2_HUMAN Fibrillin-2wextracellular matrix disassembly,extracellular matrix organization,embryonic limb morphogenesis,positive regulation of bone mineralization,sequestering of TGFbeta in extracellular matrix,camera-type eye development,positive regulation of osteoblast differentiation,embryonic eye morphogenesis,bone trabecula formation,regulation of cellular response to growth factor stimulusextracellular matrix structural constituent,calcium ion binding,protein binding,extracellular matrix constituent conferring elasticityXmicrofibril,extracellular region,proteinaceous extracellular matrix,extracellular matrixK>sp|P35556|FBN2_HUMAN Fibrillin-2 OS=Homo sapiens OX=9606 GN=FBN2 PE=1 SV=3Q14517FAT1 FAT1_HUMANProtocadherin Fat 1actin filament organization,cell adhesion,homophilic cell adhesion via plasma membrane adhesion molecules,establishment or maintenance of cell polarity,cell-cell signaling,anatomical structure morphogenesis,single organismal cell-cell adhesion,cell migrationnucleus,plasma membrane,integral component of plasma membrane,cell-cell junction,focal adhesion,lamellipodium,filopodium,perinuclear region of cytoplasm,extracellular exosomeS>sp|Q14517|FAT1_HUMAN Protocadherin Fat 1 OS=Homo sapiens OX=9606 GN=FAT1 PE=1 SV=2P53396ACLY ACLY_HUMANATP-citrate synthase.acetyl-CoA biosynthetic process,citrate metabolic process,oxaloacetate metabolic process,fatty acid biosynthetic process,cholesterol biosynthetic process,lipid biosynthetic process,positive regulation of cellular metabolic process,long-chain fatty-acyl-CoA biosynthetic process,neutrophil degranulation\ATP citrate synthase activity,protein binding,ATP binding,metal ion binding,cofactor bindingextracellular region,nucleoplasm,cytosol,plasma membrane,citrate lyase complex,membrane,azurophil granule lumen,extracellular exosome,ficolin-1-rich granule lumenT>sp|P53396|ACLY_HUMAN ATP-citrate synthase OS=Homo sapiens OX=9606 GN=ACLY PE=1 SV=3P08133ANXA6 ANXA6_HUMAN Annexin A6calcium ion transport,regulation of muscle contraction,ion transmembrane transport,protein homooligomerization,mitochondrial calcium ion homeostasis,apoptotic signaling pathwaycalcium ion binding,protein binding,GTP binding,calcium-dependent phospholipid binding,lipid binding,ligand-gated ion channel activity,cholesterol binding,protein homodimerization activity,calcium-dependent protein bindingmitochondrion,lysosomal membrane,focal adhesion,membrane,late endosome membrane,melanosome,perinuclear region of cytoplasm,extracellular exosomeL>sp|P08133|ANXA6_HUMAN Annexin A6 OS=Homo sapiens OX=9606 GN=ANXA6 PE=1 SV=3P35527KRT9 K1C9_HUMANKeratin, type I cytoskeletal 9vspermatogenesis,epidermis development,keratinization,skin development,intermediate filament organization,cornification&structural constituent of cytoskeletonXextracellular space,nucleus,cytosol,intermediate filament,membrane,extracellular exosome^>sp|P35527|K1C9_HUMAN Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3Q8WUM4PDCD6IP PDC6I_HUMAN+Programmed cell death 6-interacting proteinactomyosin contractile ring assembly,cell separation after cytokinesis,apoptotic process,regulation of centrosome duplication,protein transport,viral life cycle,multivesicular body assembly,viral budding via host ESCRT complex,maintenance of epithelial cell apical/basal polarity,bicellular tight junction assembly,regulation of membrane permeability,ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway,positive regulation of exosomal secretion,regulation of extracellular exosome assembly,positive regulation of extracellular exosome assembly,nucleus organization,mitotic metaphase plate congression,regulation of mitotic spindle assemblyyprotein binding,proteinase activated receptor binding,protein homodimerization activity,calcium-dependent protein bindingimmunological synapse,microtubule organizing center,cytosol,focal adhesion,membrane,melanosome,actomyosin,myelin sheath,extracellular exosome,endoplasmic reticulum exit site,extracellular vesicleo>sp|Q8WUM4|PDC6I_HUMAN Programmed cell death 6-interacting protein OS=Homo sapiens OX=9606 GN=PDCD6IP PE=1 SV=1Q92626PXDN PXDN_HUMANPeroxidasin homolognegative regulation of cytokine-mediated signaling pathway,immune response,response to oxidative stress,extracellular matrix organization,hydrogen peroxide catabolic process,oxidation-reduction process,cellular oxidant detoxificationperoxidase activity,interleukin-1 receptor antagonist activity,extracellular matrix structural constituent,heme binding,metal ion bindingwproteinaceous extracellular matrix,extracellular space,endoplasmic reticulum,extracellular matrix,extracellular exosomeS>sp|Q92626|PXDN_HUMAN Peroxidasin homolog OS=Homo sapiens OX=9606 GN=PXDN PE=1 SV=2P01023A2M A2MG_HUMANAlpha-2-macroglobulin@negative regulation of complement activation, lectin pathway,platelet degranulation,blood coagulation, intrinsic pathway,negative regulation of endopeptidase activity,extracellular matrix disassembly,positive regulation of GTPase activity,stem cell differentiation,regulation of small GTPase mediated signal transduction protease binding,serine-type endopeptidase inhibitor activity,GTPase activator activity,receptor binding,protein binding,growth factor binding,enzyme binding,interleukin-8 binding,interleukin-1 binding,tumor necrosis factor binding,calcium-dependent protein bindingcextracellular region,cytosol,platelet alpha granule lumen,extracellular exosome,blood microparticleT>sp|P01023|A2MG_HUMAN Alpha-2-macroglobulin OS=Homo sapiens OX=9606 GN=A2M PE=1 SV=3P14543NID1 NID1_HUMAN Nidogen-1cell-matrix adhesion,positive regulation of cell-substrate adhesion,extracellular matrix disassembly,extracellular matrix organization,glomerular basement membrane development,basement membrane organization[calcium ion binding,collagen binding,laminin binding,laminin-1 binding,proteoglycan bindingextracellular region,basement membrane,basal lamina,extracellular space,extracellular matrix,extracellular exosome,cell peripheryI>sp|P14543|NID1_HUMAN Nidogen-1 OS=Homo sapiens OX=9606 GN=NID1 PE=1 SV=3P46940IQGAP1 IQGA1_HUMAN)Ras GTPase-acti< vating-like protein IQGAP1regulation of cytokine production,signal transduction,epidermal growth factor receptor signaling pathway,fibroblast growth factor receptor signaling pathway,negative regulation of GTPase activity,negative regulation of dephosphorylation,cellular response to platelet-derived growth factor stimulus,neutrophil degranulation,positive regulation of MAP kinase activity,positive regulation of GTPase activity,positive regulation of protein kinase activity,platelet-derived growth factor receptor signaling pathway,positive regulation of focal adhesion assembly,cellular response to calcium ion,cellular response to epidermal growth factor stimulus,glomerular visceral epithelial cell development,positive regulation of dendrite development,positive regulation of peptidyl-tyrosine autophosphorylation,positive regulation of cellular protein localization,positive regulation of vascular associated smooth muscle cell migration,neuron projection extension,response to angiotensinGTPase inhibitor activity,GTPase activator activity,calcium ion binding,protein binding,calmodulin binding,phosphatidylinositol-3,4,5-trisphosphate binding,protein kinase binding,protein phosphatase binding,protein domain specific binding,protein complex binding,protein serine/threonine kinase activator activity,S100 protein binding,cadherin binding,Rac GTPase binding,mitogen-activated protein kinase bindingruffle,nucleus,cytoplasm,cytosol,microtubule,actin filament,plasma membrane,focal adhesion,lateral plasma membrane,axon,growth cone,midbody,secretory granule membrane,extrinsic component of cytoplasmic side of plasma membrane,slit diaphragm,cytoplasmic ribonucleoprotein granule,neuron projection,protein complex,membrane raft,extracellular exosome,actin cytoskeleton,microtubule cytoskeletonl>sp|P46940|IQGA1_HUMAN Ras GTPase-activating-like protein IQGAP1 OS=Homo sapiens OX=9606 GN=IQGAP1 PE=1 SV=1Q14764MVP MVP_HUMANMajor vault proteinprotein transport,negative regulation of signaling,negative regulation of protein autophosphorylation,ERBB signaling pathway,neutrophil degranulation,mRNA transport,negative regulation of protein tyrosine kinase activity\protein binding,protein kinase binding,protein phosphatase binding,identical protein bindingextracellular region,nucleus,nuclear pore,cytoplasm,cytosol,cytoskeleton,membrane,intracellular ribonucleoprotein complex,secretory granule lumen,perinuclear region of cytoplasm,extracellular exosome,ficolin-1-rich granule lumenQ>sp|Q14764|MVP_HUMAN Major vault protein OS=Homo sapiens OX=9606 GN=MVP PE=1 SV=4P07996THBS1 TSP1_HUMANThrombospondin-1Q activation of MAPK activity,response to hypoxia,negative regulation of endothelial cell proliferation,negative regulation of cell-matrix adhesion,sprouting angiogenesis,chronic inflammatory response,platelet degranulation,negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II,negative regulation of dendritic cell antigen processing and presentation,inflammatory response,immune response,response to unfolded protein,cell cycle arrest,cell adhesion,positive regulation of cell proliferation,response to mechanical stimulus,response to glucose,positive regulation of endothelial cell migration,negative regulation of endothelial cell migration,negative regulation of plasma membrane long-chain fatty acid transport,negative regulation of nitric oxide mediated signal transduction,negative regulation of cGMP-mediated signaling,negative regulation of plasminogen activation,positive regulation of macrophage chemotaxis,positive regulation of fibroblast migration,cell migration,negative regulation of angiogenesis,peptide cross-linking,positive regulation of blood coagulation,extracellular matrix organization,positive regulation of cell migration,positive regulation of transforming growth factor beta receptor signaling pathway,regulation of cGMP metabolic process,response to magnesium ion,response to progesterone,negative regulation of interleukin-12 production,positive regulation of transforming growth factor beta1 production,response to testosterone,cellular response to heat,response to endoplasmic reticulum stress,protein O-linked fucosylation,negative regulation of fibroblast growth factor receptor signaling pathway,positive regulation of phosphorylation,response to drug,positive regulation of tumor necrosis factor biosynthetic process,positive regulation of macrophage activation,negative regulation of apoptotic process,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process,positive regulation of blood vessel endothelial cell migration,negative regulation of blood vessel endothelial cell migration,engulfment of apoptotic cell,positive regulation of translation,positive regulation of angiogenesis,behavioral response to pain,positive regulation of smooth muscle cell proliferation,positive regulation of chemotaxis,response to calcium ion,negative regulation of focal adhesion assembly,positive regulation of protein kinase B signaling,negative regulation of fibrinolysis,cellular response to tumor necrosis factor,cellular response to growth factor stimulus,positive regulation of extrinsic apoptotic signaling pathway via death domain receptors,positive regulation of endothelial cell apoptotic process,positive regulation of reactive oxygen species metabolic process,negative regulation of endothelial cell chemotaxis,negative regulation of extrinsic apoptotic signaling pathway_phosphatidylserine binding,glycoprotein binding,fibronectin binding,integrin binding,calcium ion binding,protein binding,heparin binding,fibroblast growth factor binding,low-density lipoprotein particle binding,identical protein binding,laminin binding,proteoglycan binding,transforming growth factor beta binding,fibrinogen binding,collagen V binding#extracellular region,fibrinogen complex,extracellular space,endoplasmic reticulum,endoplasmic reticulum lumen,external side of plasma membrane,cell surface,sarcoplasmic reticulum,secretory granule,extracellular matrix,platelet alpha granule,platelet alpha granule lumen,extracellular exosomeQ>sp|P07996|TSP1_HUMAN Thrombospondin-1 OS=Homo sapiens OX=9606 GN=THBS1 PE=1 SV=2P12814ACTN1 ACTN1_HUMANAlpha-actinin-1}platelet degranulation,actin filament organization,platelet formation,platelet morphogenesis,regulation of apoptotic process,focal adhesion assembly,actin filament bundle assembly,negative regulation of cellular component movement,actin filament network formation,actin crosslink formation,regulation of nucleic acid-templated transcription,platelet activation,platelet aggregationdouble-stranded RNA binding,integrin binding,calcium ion binding,protein binding,vinculin binding,ligand-dependent nuclear receptor transcription coactivator activity,protein homodimerization activity,ion channel binding,actin filament bindingstress fiber,ruffle,extracellular region,extracellular space,intracellular,cytoplasm,cytosol,plasma membrane,brush border,cell-cell junction,fascia adherens,focal adhesion,Z disc,platelet alpha granule lumen,pseudopodium,cell projection,extracellular exosome,actin filamentQ>sp|P12814|ACTN1_HUMAN Alpha-actinin-1 OS=Homo sapiens OX=9606 GN=ACTN1 PE=1 SV=2Q02388COL7A1 CO7A1_HUMANCollagen alpha-1(VII) chainER to Golgi vesicle-mediated transport,cell adhesion,epidermis development,negative regulation of endopeptidase activity,extracellular matrix organization,collagen catabolic process,endodermal cell differentiation,COPII vesicle coatingVserine-type endopeptidase inhibitor activity,protein binding,identical protein bindingGolgi membrane,extracellular region,collagen type VII trimer,basement membrane,extracellular space,endoplasmic reticulum lumen,ER to Golgi transport vesicle,endoplasmic reticulum-Golgi intermediate compartment membrane,extracellular matrix^>sp|Q02388|CO7A1_HUMAN Collagen alpha-1(VII) chain OS=Homo sapiens OX=9606 GN=COL7A1 PE=1 SV=2P08123COL1A2 CO1A2_HUMANCollagen alpha-2(I) chainskeletal system development,blood vessel development,transforming growth factor beta receptor signaling path< way,Rho protein signal transduction,blood coagulation,regulation of blood pressure,platelet activation,extracellular matrix organization,collagen fibril organization,collagen catabolic process,odontogenesis,skin morphogenesis,regulation of immune response,leukocyte migration,protein heterotrimerization,cellular response to amino acid stimulusextracellular matrix structural constituent,protein binding,protein binding, bridging,identical protein binding,SMAD binding,metal ion binding,platelet-derived growth factor bindingextracellular region,collagen type I trimer,extracellular space,endoplasmic reticulum,endoplasmic reticulum lumen,extracellular matrix,extracellular exosome\>sp|P08123|CO1A2_HUMAN Collagen alpha-2(I) chain OS=Homo sapiens OX=9606 GN=COL1A2 PE=1 SV=7Q6UVK1CSPG4 CSPG4_HUMAN"Chondroitin sulfate proteoglycan 4activation of MAPK activity,angiogenesis,transmembrane receptor protein tyrosine kinase signaling pathway,cell proliferation,glial cell migration,glycosaminoglycan metabolic process,chondroitin sulfate biosynthetic process,chondroitin sulfate catabolic process,dermatan sulfate biosynthetic process,intracellular signal transduction,tissue remodeling,positive regulation of peptidyl-tyrosine phosphorylation1signal transducer activity,protein kinase bindingextracellular region,Golgi lumen,integral component of plasma membrane,focal adhesion,cell surface,apical plasma membrane,lamellipodium membrane,lysosomal lumen,extracellular exosomed>sp|Q6UVK1|CSPG4_HUMAN Chondroitin sulfate proteoglycan 4 OS=Homo sapiens OX=9606 GN=CSPG4 PE=1 SV=2P49327FASN FAS_HUMANFatty acid synthaseMosteoblast differentiation,acetyl-CoA metabolic process,fatty acid metabolic process,fatty acid biosynthetic process,pantothenate metabolic process,mammary gland development,positive regulation of cellular metabolic process,long-chain fatty-acyl-CoA biosynthetic process,oxidation-reduction process,cellular response to interleukin-4LRNA binding,fatty acid synthase activity,[acyl-carrier-protein] S-acetyltransferase activity,[acyl-carrier-protein] S-malonyltransferase activity,3-oxoacyl-[acyl-carrier-protein] synthase activity,3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity,3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity,enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity,oleoyl-[acyl-carrier-protein] hydrolase activity,protein binding,drug binding,myristoyl-[acyl-carrier-protein] hydrolase activity,palmitoyl-[acyl-carrier-protein] hydrolase activity,phosphopantetheine binding,protein homodimerization activity,cadherin binding,enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity,3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity,NADPH binding,3-oxo-pimeloyl-[acp] methyl ester reductase activitypmitochondrion,Golgi apparatus,cytosol,plasma membrane,membrane,melanosome,glycogen granule,extracellular exosomeR>sp|P49327|FAS_HUMAN Fatty acid synthase OS=Homo sapiens OX=9606 GN=FASN PE=1 SV=3Q9NZM1MYOF MYOF_HUMAN Myoferlinplasma membrane repair,muscle contraction,myoblast fusion,blood circulation,regulation of vascular endothelial growth factor receptor signaling pathway,cellular response to heat$protein binding,phospholipid bindingnuclear envelope,plasma membrane,caveola,integral component of membrane,cytoplasmic vesicle membrane,cytoplasmic vesicle,nuclear membrane,intracellular membrane-bounded organelle,extracellular exosomeI>sp|Q9NZM1|MYOF_HUMAN Myoferlin OS=Homo sapiens OX=9606 GN=MYOF PE=1 SV=1P02452COL1A1 CO1A1_HUMANCollagen alpha-1(I) chainskeletal system development,blood vessel development,osteoblast differentiation,intramembranous ossification,endochondral ossification,blood coagulation,visual perception,sensory perception of sound,positive regulation of epithelial to mesenchymal transition,negative regulation of cell-substrate adhesion,protein transport,platelet activation,extracellular matrix organization,collagen fibril organization,positive regulation of cell migration,collagen catabolic process,response to corticosteroid,response to estradiol,collagen biosynthetic process,protein localization to nucleus,tooth mineralization,collagen-activated tyrosine kinase receptor signaling pathway,response to drug,response to hydrogen peroxide,response to peptide hormone,skin morphogenesis,cellular response to fibroblast growth factor stimulus,tooth eruption,positive regulation of transcription, DNA-templated,embryonic skeletal system development,regulation of immune response,leukocyte migration,response to cAMP,response to hyperoxia,face morphogenesis,bone trabecula formation,cartilage development involved in endochondral bone morphogenesis,protein heterotrimerization,cellular response to amino acid stimulus,cellular response to mechanical stimulus,cellular response to retinoic acid,cellular response to vitamin E,cellular response to tumor necrosis factor,cellular response to epidermal growth factor stimulus,cellular response to transforming growth factor beta stimulus,positive regulation of canonical Wnt signaling pathway,cellular response to fluorideextracellular matrix structural constituent,protein binding,identical protein binding,metal ion binding,platelet-derived growth factor bindingextracellular region,collagen type I trimer,extracellular space,endoplasmic reticulum lumen,Golgi apparatus,secretory granule,extracellular matrix\>sp|P02452|CO1A1_HUMAN Collagen alpha-1(I) chain OS=Homo sapiens OX=9606 GN=COL1A1 PE=1 SV=5O00468AGRN AGRIN_HUMANAgrinAretinoid metabolic process,glycosaminoglycan biosynthetic process,glycosaminoglycan catabolic process,cytoskeleton organization,signal transduction,G-protein coupled acetylcholine receptor signaling pathway,extracellular matrix organization,glycosaminoglycan metabolic process,receptor clustering,positive regulation of GTPase activity,clustering of voltage-gated sodium channels,positive regulation of synaptic growth at neuromuscular junction,positive regulation of transcription from RNA polymerase II promoter,synapse organization,positive regulation of filopodium assemblydystroglycan binding,structural constituent of cytoskeleton,calcium ion binding,protein binding,sialic acid binding,chondroitin sulfate binding,laminin binding,heparan sulfate proteoglycan bindingextracellular region,basal lamina,Golgi lumen,cytosol,plasma membrane,integral component of membrane,cell junction,extracellular matrix,lysosomal lumen,synapse,extracellular exosomeF>sp|O00468|AGRIN_HUMAN Agrin OS=Homo sapiens OX=9606 GN=AGRN PE=1 SV=6Q9Y490TLN1 TLN1_HUMANTalin-1.platelet degranulation,movement of cell or subcellular component,muscle contraction,cytoskeletal anchoring at plasma membrane,cell-cell junction assembly,cell-substrate junction assembly,viral process,cortical actin cytoskeleton organization,IRE1-mediated unfolded protein response,platelet aggregationintegrin binding,structural constituent of cytoskeleton,protein binding,vinculin binding,LIM domain binding,cadherin binding,actin filament bindingruffle,extracellular region,cytosol,cytoskeleton,cell-cell junction,focal adhesion,cell surface,ruffle membrane,extracellular exosomeG>sp|Q9Y490|TLN1_HUMAN Talin-1 OS=Homo sapiens OX=9606 GN=TLN1 PE=1 SV=3O15230LAMA5 LAMA5_HUMANLaminin subunit alpha-53angiogenesis,branching involved in ureteric bud morphogenesis,morphogenesis of a polarized epithelium,neural crest cell migration,hair follicle development,cytoskeleton organization,integrin-mediated signaling pathway,muscle organ development,cell recognition,cell proliferation,embryo development,morphogenesis of embryonic epithelium,cell migration,cell differentiation,regulation of cell adhesion,extracellular matrix organization,lung development,regulation of cell migration,substrate adhesion-dependent cell spreading,regulation of cell proliferation,odontogenesis of dentin-containing tooth,endothelial cell differentiation,regulation of embryonic development,focal adhesion assembly,cilium morphogenesis,branching involved in salivary gland morphogenesis,establishment of protein localization to plasma membrane< extracellular region,basement membrane,basal lamina,laminin-5 complex,extracellular space,nucleus,extracellular matrix,synaptic cleft,laminin-10 complex,laminin-11 complex,extracellular exosomeY>sp|O15230|LAMA5_HUMAN Laminin subunit alpha-5 OS=Homo sapiens OX=9606 GN=LAMA5 PE=1 SV=8Q4LDE5SVEP1 SVEP1_HUMANRSushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1%chromatin binding,calcium ion binding&extracellular space,cytoplasm,membrane>sp|Q4LDE5|SVEP1_HUMAN Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SVEP1 PE=1 SV=3Q01082SPTBN1 SPTB2_HUMAN'Spectrin beta chain, non-erythrocytic 1MAPK cascade,mitotic cytokinesis,ER to Golgi vesicle-mediated transport,plasma membrane organization,cytoskeleton organization,common-partner SMAD protein phosphorylation,SMAD protein import into nucleus,axon guidance,Golgi to plasma membrane protein transport,positive regulation of GTPase activity,actin filament capping,membrane assembly,protein targeting to plasma membrane,positive regulation of interleukin-2 secretion,regulation of protein localization to plasma membrane,positive regulation of protein localization to plasma membraneRNA binding,actin binding,Ras guanyl-nucleotide exchange factor activity,structural constituent of cytoskeleton,protein binding,calmodulin binding,phospholipid binding,ankyrin binding,protein complex binding,cadherin binding,GTPase bindingnucleolus,cytoplasm,cytosol,spectrin,postsynaptic density,spectrin-associated cytoskeleton,axolemma,M band,cuticular plate,protein complex,extracellular exosomej>sp|Q01082|SPTB2_HUMAN Spectrin beta chain, non-erythrocytic 1 OS=Homo sapiens OX=9606 GN=SPTBN1 PE=1 SV=2Q15075EEA1 EEA1_HUMANEarly endosome antigen 1endocytosis,vesicle fusion,synaptic vesicle to endosome fusion,viral RNA genome replication,early endosome to late endosome transportprotein binding,calmodulin binding,1-phosphatidylinositol binding,zinc ion binding,GTP-dependent protein binding,protein homodimerization activitycytoplasm,early endosome,cytosol,serine-pyruvate aminotransferase complex,membrane,extrinsic component of plasma membrane,early endosome membrane,axonal spine,recycling endosome,extracellular exosome,presynapseX>sp|Q15075|EEA1_HUMAN Early endosome antigen 1 OS=Homo sapiens OX=9606 GN=EEA1 PE=1 SV=2O75369FLNB FLNB_HUMAN Filamin-Bkeratinocyte development,epithelial cell morphogenesis,cytoskeletal anchoring at plasma membrane,signal transduction,skeletal muscle tissue development,actin cytoskeleton organizationTRNA binding,actin binding,protein binding,identical protein binding,cadherin bindingstress fiber,cytoplasm,cytosol,plasma membrane,brush border,focal adhesion,cell cortex,actin cytoskeleton,integral component of membrane,Z disc,extracellular matrix,extracellular exosomeI>sp|O75369|FLNB_HUMAN Filamin-B OS=Homo sapiens OX=9606 GN=FLNB PE=1 SV=2P15924DSP DESP_HUMAN Desmoplakindesmosome organization,ventricular compact myocardium morphogenesis,epidermis development,peptide cross-linking,keratinocyte differentiation,keratinization,adherens junction organization,wound healing,neutrophil degranulation,intermediate filament organization,cornification,protein localization to adherens junction,bundle of His cell-Purkinje myocyte adhesion involved in cell communication,regulation of heart rate by cardiac conduction,regulation of ventricular cardiac muscle cell action potential&RNA binding,protein kinase C binding,structural molecule activity,structural constituent of cytoskeleton,protein binding,protein binding, bridging,cell adhesion molecule binding,cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication,scaffold protein bindingcornified envelope,nucleus,plasma membrane,fascia adherens,intercalated disc,basolateral plasma membrane,desmosome,extracellular matrix,extracellular exosome,ficolin-1-rich granule membrane,intermediate filamentJ>sp|P15924|DESP_HUMAN Desmoplakin OS=Homo sapiens OX=9606 GN=DSP PE=1 SV=3P07942LAMB1 LAMB1_HUMANLaminin subunit beta-1Vcell adhesion,neuronal-glial interaction involved in cerebral cortex radial glia guided migration,extracellular matrix organization,positive regulation of cell migration,neuron projection development,substrate adhesion-dependent cell spreading,endodermal cell differentiation,odontogenesis,positive regulation of epithelial cell proliferationHstructural molecule activity,extracellular matrix structural constituentextracellular region,basement membrane,laminin-1 complex,laminin-2 complex,extracellular space,extracellular matrix,laminin-8 complex,laminin-10 complex,perinuclear region of cytoplasm,extracellular exosomeX>sp|P07942|LAMB1_HUMAN Laminin subunit beta-1 OS=Homo sapiens OX=9606 GN=LAMB1 PE=1 SV=2P11047LAMC1 LAMC1_HUMANLaminin subunit gamma-13protein complex assembly,cell adhesion,endoderm development,cell migration,extracellular matrix disassembly,extracellular matrix organization,hemidesmosome assembly,substrate adhesion-dependent cell spreading,system development,positive regulation of epithelial cell proliferation,basement membrane assemblyextracellular region,basement membrane,laminin-1 complex,extracellular space,extracellular matrix,laminin-10 complex,laminin-11 complex,extracellular exosomeY>sp|P11047|LAMC1_HUMAN Laminin subunit gamma-1 OS=Homo sapiens OX=9606 GN=LAMC1 PE=1 SV=3Q00610CLTC CLH1_HUMANClathrin heavy chain 18osteoblast differentiation,intracellular protein transport,receptor-mediated endocytosis,autophagy,microtubule-based movement,mitotic nuclear division,antigen processing and presentation of exogenous peptide antigen via MHC class II,receptor internalization,transferrin transport,retrograde transport, endosome to Golgi,cell division,Wnt signaling pathway, planar cell polarity pathway,regulation of mitotic spindle organization,membrane organization,negative regulation of hyaluronan biosynthetic process,negative regulation of protein localization to plasma membraneRNA binding,double-stranded RNA binding,structural molecule activity,protein binding,protein kinase binding,clathrin light chain bindinglysosome,endosome,spindle,cytosol,plasma membrane,focal adhesion,membrane,clathrin coat,clathrin coat of trans-Golgi network vesicle,clathrin coat of coated pit,clathrin-coated vesicle,clathrin-coated endocytic vesicle membrane,extracellular matrix,trans-Golgi network membrane,endolysosome membrane,melanosome,protein complex,extracellular exosome,clathrin complex,extracellular vesicle,mitotic spindle microtubuleV>sp|Q00610|CLH1_HUMAN Clathrin heavy chain 1 OS=Homo sapiens OX=9606 GN=CLTC PE=1 SV=5Q16363LAMA4 LAMA4_HUMANLaminin subunit alpha-4cell adhesion,regulation of cell adhesion,extracellular matrix organization,regulation of cell migration,regulation of embryonic developmentLreceptor binding,extracellular matrix structural constituent,protein binding^extracellular region,basement membrane,basal lamina,extracellular exosome,extracellular matrixY>sp|Q16363|LAMA4_HUMAN Laminin subunit alpha-4 OS=Homo sapiens OX=9606 GN=LAMA4 PE=1 SV=4P24043LAMA2 LAMA2_HUMANLaminin subunit alpha-2 cell adhesion,axon guidance,muscle organ development,Schwann cell differentiation,regulation of cell adhesion,extracellular matrix organization,regulation of cell migration,positive regulation of synaptic transmission, cholinergic,regulation of embryonic development-receptor binding,structural molecule activityextracellular region,basement membrane,basal lamina,extracellular space,sarcolemma,dendritic spine,extracellular exosome,extracellular matrixY>sp|P24043|LAMA2_HUMAN Laminin subunit alpha-2 OS=Homo sapiens OX=9606 GN=LAMA2 PE=1 SV=4Q09666AHNAK AHNK_HUMAN3Neuroblast differentiation-associated protein AHNAKgregulation of RNA splicing,protein oligomerization,regulation of voltage-gated calcium channel activitytRNA binding,protein binding,S100 protein binding,cadherin binding,structural molecule activity conferring elasticitynucleus,cytoplasm,lysosomal membrane,cyto< sol,plasma membrane,focal adhesion,actin cytoskeleton,membrane,T-tubule,vesicle,sarcolemma,costamere,cell-cell contact zone,extracellular exosome,membrane raftt>sp|Q09666|AHNK_HUMAN Neuroblast differentiation-associated protein AHNAK OS=Homo sapiens OX=9606 GN=AHNAK PE=1 SV=2Q13813SPTAN1 SPTN1_HUMAN(Spectrin alpha chain, non-erythrocytic 1MAPK cascade,ER to Golgi vesicle-mediated transport,cytoskeleton organization,axon guidance,neutrophil degranulation,positive regulation of GTPase activity,actin filament cappingactin binding,Ras guanyl-nucleotide exchange factor activity,structural constituent of cytoskeleton,calcium ion binding,protein binding,calmodulin binding,cadherin bindingextracellular region,cytosol,spectrin,microtubule cytoskeleton,membrane,specific granule lumen,intracellular membrane-bounded organelle,extracellular exosome,extracellular vesicle,tertiary granule lumenk>sp|Q13813|SPTN1_HUMAN Spectrin alpha chain, non-erythrocytic 1 OS=Homo sapiens OX=9606 GN=SPTAN1 PE=1 SV=3Q14315FLNC FLNC_HUMAN Filamin-C/cell junction assembly,muscle fiber developmentSprotein binding,cytoskeletal protein binding,ankyrin binding,actin filament bindingdcytoplasm,cytosol,cytoskeleton,plasma membrane,focal adhesion,sarcoplasm,Z disc,sarcolemma,costamereI>sp|Q14315|FLNC_HUMAN Filamin-C OS=Homo sapiens OX=9606 GN=FLNC PE=1 SV=3P25391LAMA1 LAMA1_HUMANLaminin subunit alpha-1cell adhesion,cell surface receptor signaling pathway,regulation of cell adhesion,extracellular matrix organization,regulation of cell migration,regulation of embryonic developmentextracellular region,proteinaceous extracellular matrix,basement membrane,laminin-1 complex,laminin-3 complex,extracellular space,extracellular matrixY>sp|P25391|LAMA1_HUMAN Laminin subunit alpha-1 OS=Homo sapiens OX=9606 GN=LAMA1 PE=1 SV=2P21333FLNA FLNA_HUMAN Filamin-Aplatelet degranulation,adenylate cyclase-inhibiting dopamine receptor signaling pathway,negative regulation of transcription from RNA polymerase I promoter,formation of radial glial scaffolds,cerebral cortex development,platelet activation,regulation of cell migration,actin cytoskeleton reorganization,cell junction assembly,protein localization to cell surface,negative regulation of protein catabolic process,mRNA transcription from RNA polymerase II promoter,positive regulation of transcription factor import into nucleus,negative regulation of apoptotic process,receptor clustering,positive regulation of I-kappaB kinase/NF-kappaB signaling,negative regulation of sequence-specific DNA binding transcription factor activity,wound healing, spreading of cells,establishment of protein localization,protein stabilization,cytoplasmic sequestering of protein,actin crosslink formation,cilium morphogenesis,platelet aggregation,semaphorin-plexin signaling pathway,protein localization to plasma membrane,mitotic spindle assembly,positive regulation of substrate adhesion-dependent cell spreading,positive regulation of potassium ion transmembrane transport,regulation of membrane repolarization during atrial cardiac muscle cell action potential,regulation of membrane repolarization during cardiac muscle cell action potential,positive regulation of neural precursor cell proliferation,positive regulation of integrin-mediated signaling pathway,positive regulation of neuron migrationG-protein coupled receptor binding,glycoprotein binding,RNA binding,signal transducer activity,protein binding,transcription factor binding,potassium channel regulator activity,Rho GTPase binding,Ral GTPase binding,kinase binding,small GTPase binding,mu-type opioid receptor binding,Fc-gamma receptor I complex binding,protein homodimerization activity,ion channel binding,cadherin binding,SMAD binding,Rac GTPase binding,actin filament binding,GTPase binding?extracellular region,nucleus,nucleolus,cytoplasm,cytosol,plasma membrane,cell-cell junction,focal adhesion,actin cytoskeleton,membrane,Z disc,cortical cytoskeleton,extracellular matrix,Myb complex,neuronal cell body,dendritic shaft,perinuclear region of cytoplasm,extracellular exosome,apical dendrite,filamentous actinI>sp|P21333|FLNA_HUMAN Filamin-A OS=Homo sapiens OX=9606 GN=FLNA PE=1 SV=4P02751FN1 FINC_HUMAN FibronectinMangiogenesis,regulation of protein phosphorylation,platelet degranulation,acute-phase response,cell-substrate junction assembly,cell adhesion,calcium-independent cell-matrix adhesion,positive regulation of cell proliferation,regulation of cell shape,response to wounding,positive regulation of gene expression,positive regulation of peptidase activity,peptide cross-linking,extracellular matrix disassembly,extracellular matrix organization,integrin activation,substrate adhesion-dependent cell spreading,endodermal cell differentiation,wound healing,positive regulation of axon extension,positive regulation of fibroblast proliferation,leukocyte migration,regulation of ERK1 and ERK2 cascade,positive regulation of substrate-dependent cell migration, cell attachment to substrate,negative regulation of transforming growth factor-beta secretionprotease binding,integrin binding,protein binding,collagen binding,heparin binding,peptidase activator activity,identical protein bindingextracellular region,fibrinogen complex,proteinaceous extracellular matrix,basal lamina,extracellular space,endoplasmic reticulum-Golgi intermediate compartment,apical plasma membrane,extracellular matrix,platelet alpha granule lumen,extracellular exosome,blood microparticleJ>sp|P02751|FINC_HUMAN Fibronectin OS=Homo sapiens OX=9606 GN=FN1 PE=1 SV=5P98160HSPG2 PGBM_HUMANDBasement membrane-specific heparan sulfate proteoglycan core proteinretinoid metabolic process,angiogenesis,glycosaminoglycan biosynthetic process,glycosaminoglycan catabolic process,extracellular matrix disassembly,extracellular matrix organization,glycosaminoglycan metabolic process,cellular protein metabolic process>calcium ion binding,protein binding,protein C-terminus bindingextracellular region,basement membrane,extracellular space,Golgi lumen,plasma membrane,focal adhesion,extracellular matrix,lysosomal lumen,extracellular exosome>sp|P98160|PGBM_HUMAN Basement membrane-specific heparan sulfate proteoglycan core protein OS=Homo sapiens OX=9606 GN=HSPG2 PE=1 SV=4P35579MYH9 MYH9_HUMANMyosin-9meiotic spindle organization,cytokinesis,angiogenesis,in utero embryonic development,establishment of T cell polarity,membrane protein ectodomain proteolysis,phagocytosis, engulfment,integrin-mediated signaling pathway,myoblast fusion,regulation of cell shape,protein transport,actin filament-based movement,platelet formation,monocyte differentiation,actomyosin structure organization,actin cytoskeleton reorganization,uropod organization,blood vessel endothelial cell migration,leukocyte migration,establishment of meiotic spindle localization,platelet aggregation,negative regulation of actin filament severing,positive regulation of protein processing in phagocytic vesicle)microfilament motor activity,RNA binding,motor activity,actin binding,protein binding,calmodulin binding,ATP binding,ATPase activity,protein domain specific binding,actin-dependent ATPase activity,protein homodimerization activity,protein anchor,ADP binding,cadherin binding,actin filament bindingstress fiber,ruffle,uropod,nucleus,cytoplasm,spindle,actomyosin contractile ring,cytosol,plasma membrane,brush border,cell-cell adherens junction,actin cytoskeleton,membrane,myosin II complex,extracellular matrix,cell leading edge,neuromuscular junction,cleavage furrow,actomyosin,protein complex,extracellular exosome,myosin II filament,immunological synapse,focal adhesion,COP9 signalosome,integrin complexH>sp|P35579|MYH9_HUMAN Myosin-9 OS=Homo sapiens OX=9606 GN=MYH9 PE=1 SV=4Q99715COL12A1 COCA1_HUMANCollagen alpha-1(XII) chainskeletal system development,cell adhesion,collagen fibril organization,collagen catabolic process,endodermal cell differentiationGextracellular matrix structural constituent conferring tensile strengthextracellular region,collagen type XII trimer,extracellular space,endoplasmic reticulum< lumen,extracellular matrix,extracellular exosome,extracellular vesicle_>sp|Q99715|COCA1_HUMAN Collagen alpha-1(XII) chain OS=Homo sapiens OX=9606 GN=COL12A1 PE=1 SV=2Q15149PLEC PLEC_HUMANPlectinhemidesmosome assemblykRNA binding,actin binding,protein binding,structural constituent of muscle,ankyrin binding,cadherin bindingcytosol,plasma membrane,brush border,focal adhesion,sarcoplasm,hemidesmosome,extracellular matrix,sarcolemma,costamere,intermediate filament cytoskeleton,extracellular exosomeG>sp|Q15149|PLEC_HUMAN Plectin OS=Homo sapiens OX=9606 GN=PLEC PE=1 SV=3Q14204DYNC1H1 DYHC1_HUMAN"Cytoplasmic dynein 1 heavy chain 1rG2/M transition of mitotic cell cycle,ER to Golgi vesicle-mediated transport,microtubule-based movement,mitotic spindle organization,antigen processing and presentation of exogenous peptide antigen via MHC class II,cytoplasmic mRNA processing body assembly,stress granule assembly,neutrophil degranulation,establishment of spindle localization,ciliary basal body dockingRNA binding,protein binding,ATP binding,dynein light intermediate chain binding,ATP-dependent microtubule motor activity, minus-end-directedextracellular region,centrosome,cytosol,cytoplasmic dynein complex,microtubule,membrane,filopodium,extracellular matrix,azurophil granule lumen,extracellular exosomef>sp|Q14204|DYHC1_HUMAN Cytoplasmic dynein 1 heavy chain 1 OS=Homo sapiens OX=9606 GN=DYNC1H1 PE=1 SV=5P12111COL6A3 CO6A3_HUMANCollagen alpha-3(VI) chaincell adhesion,muscle organ development,negative regulation of endopeptidase activity,extracellular matrix organization,collagen catabolic processextracellular region,proteinaceous extracellular matrix,collagen type VI trimer,extracellular space,endoplasmic reticulum lumen,extracellular matrix,sarcolemma,extracellular exosome,extracellular vesicle]>sp|P12111|CO6A3_HUMAN Collagen alpha-3(VI) chain OS=Homo sapiens OX=9606 GN=COL6A3 PE=1 SV=5742 proteins are up-regulated. 120 proteins are down-regulated.Doxo / QuiescentDoxoP46108CRK CRK_HUMANAdapter molecule crkgactivation of MAPKK activity,response to yeast,regulation of transcription from RNA polymerase II promoter,positive regulation of smooth muscle cell migration,regulation of actin cytoskeleton organization,regulation of Rac protein signal transduction,response to hepatocyte growth factor,Fc-gamma receptor signaling pathway involved in phagocytosis,response to hydrogen peroxide,regulation of GTPase activity,negative regulation of natural killer cell mediated cytotoxicity,vascular endothelial growth factor receptor signaling pathway,ephrin receptor signaling pathway,cellular response to transforming growth factor beta stimulus,cellular response to nitric oxide,positive regulation of substrate adhesion-dependent cell spreading,cellular response to nerve growth factor stimulus,cellular response to insulin-like growth factor stimulus,cellular response to endothelinSH3/SH2 adaptor activity,insulin-like growth factor receptor binding,protein binding,cytoskeletal protein binding,SH2 domain binding,protein phosphorylated amino acid binding,ephrin receptor binding,scaffold protein binding,protein tyrosine kinase binding`nucleus,cytoplasm,cytosol,plasma membrane,actin cytoskeleton,membrane raft,extracellular exosomeR>sp|P46108|CRK_HUMAN Adapter molecule crk OS=Homo sapiens OX=9606 GN=CRK PE=1 SV=2P43487RANBP1 RANG_HUMAN&Ran-specific GTPase-activating proteinG1/S transition of mitotic cell cycle,RNA export from nucleus,ubiquitin-dependent protein catabolic process,protein import into nucleus,spindle organization,signal transduction,viral process,positive regulation of GTPase activity,positive regulation of mitotic centrosome separationqGDP-dissociation inhibitor activity,protein binding,Ran GTPase binding,cadherin binding,GTPase activator activity5nucleus,nuclear envelope,cytoplasm,centrosome,cytosolh>sp|P43487|RANG_HUMAN Ran-specific GTPase-activating protein OS=Homo sapiens OX=9606 GN=RANBP1 PE=1 SV=1Q9H3N1TMX1 TMX1_HUMAN+Thioredoxin-related transmembrane protein 1kprotein folding,response to endoplasmic reticulum stress,cell redox homeostasis,oxidation-reduction processFprotein disulfide isomerase activity,disulfide oxidoreductase activity=endoplasmic reticulum membrane,integral component of membranek>sp|Q9H3N1|TMX1_HUMAN Thioredoxin-related transmembrane protein 1 OS=Homo sapiens OX=9606 GN=TMX1 PE=1 SV=1Q13501SQSTM1 SQSTM_HUMANSequestosome-1knegative regulation of transcription from RNA polymerase II promoter,mitophagy,positive regulation of protein phosphorylation,immune system process,protein phosphorylation,ubiquitin-dependent protein catabolic process,autophagy,apoptotic process,response to stress,protein localization,regulation of mitochondrion organization,endosomal transport,macroautophagy,positive regulation of macroautophagy,cell differentiation,intracellular signal transduction,positive regulation of apoptotic process,negative regulation of apoptotic process,regulation of I-kappaB kinase/NF-kappaB signaling,negative regulation of growth of symbiont in host,positive regulation of transcription from RNA polymerase II promoter,regulation of Ras protein signal transduction,protein heterooligomerization,regulation of protein complex stability,mitophagy in response to mitochondrial depolarization=protein serine/threonine kinase activity,protein kinase C binding,protein binding,zinc ion binding,protein kinase binding,receptor tyrosine kinase binding,ubiquitin protein ligase binding,SH2 domain binding,identical protein binding,protein homodimerization activity,ubiquitin binding,K63-linked polyubiquitin bindingpre-autophagosomal structure,cytoplasmic mRNA processing body,nucleoplasm,cytoplasm,late endosome,autophagosome,endoplasmic reticulum,cytosol,inclusion body,aggresome,PML body,intracellular membrane-bounded organelle,amphisome,autolysosome,extracellular exosome,sperm midpieceQ>sp|Q13501|SQSTM_HUMAN Sequestosome-1 OS=Homo sapiens OX=9606 GN=SQSTM1 PE=1 SV=1Q15181PPA1 IPYR_HUMANInorganic pyrophosphataseytRNA aminoacylation for protein translation,phosphate-containing compound metabolic process,diphosphate metabolic process6magnesium ion binding,inorganic diphosphatase activityY>sp|Q15181|IPYR_HUMAN Inorganic pyrophosphatase OS=Homo sapiens OX=9606 GN=PPA1 PE=1 SV=2O14964HGS HGS_HUMAN<Hepatocyte growth factor-regulated tyrosine kinase substrateprotein targeting to lysosome,signal transduction,negative regulation of cell proliferation,membrane invagination,positive regulation of gene expression,endosomal transport,macroautophagy,protein deubiquitination,multivesicular body assembly,negative regulation of epidermal growth factor receptor signaling pathway,regulation of protein catabolic process,regulation of MAP kinase activity,negative regulation of JAK-STAT cascade,membrane organization,protein localization to membrane,positive regulation of exosomal secretionAprotein binding,protein domain specific binding,metal ion bindinglysosome,endosome,early endosome,cytosol,early endosome membrane,multivesicular body membrane,ESCRT-0 complex,intracellular membrane-bounded organelle,extracellular exosomez>sp|O14964|HGS_HUMAN Hepatocyte growth factor-regulated tyrosine kinase substrate OS=Homo sapiens OX=9606 GN=HGS PE=1 SV=1Q6IBS0TWF2 TWF2_HUMAN Twinfilin-2positive regulation of lamellipodium assembly,positive regulation of neuron projection development,cell projection organization,negative regulation of actin filament polymerization,regulation of microvillus length,regulation of actin cytoskeleton organization,sequestering of actin monomers,positive regulation of axon extension,barbed-end actin filament capping,cellular response to retinoic acid,cellular response to growth factor stimulusRNA binding,actin monomer binding,protein kinase C binding,protein binding,ATP binding,phosphatidylinositol-4,5-bisphosphate binding,cadherin bindingcytoplasm,cytoskeleton,myofibril,lamellipodium,filopodium,growth cone,stereocilium,perinuclear region of cytoplasm,extracellular exos< omeK>sp|Q6IBS0|TWF2_HUMAN Twinfilin-2 OS=Homo sapiens OX=9606 GN=TWF2 PE=1 SV=2P07099EPHX1 HYEP_HUMANEpoxide hydrolase 1xenobiotic metabolic process,response to toxic substance,response to organic cyclic compound,aromatic compound catabolic process@epoxide hydrolase activity,cis-stilbene-oxide hydrolase activityPendoplasmic reticulum membrane,integral component of membrane,organelle membraneT>sp|P07099|HYEP_HUMAN Epoxide hydrolase 1 OS=Homo sapiens OX=9606 GN=EPHX1 PE=1 SV=1P48506GCLC GSH1_HUMAN,Glutamate--cysteine ligase catalytic subunitsulfur amino acid metabolic process,cysteine metabolic process,glutamate metabolic process,glutathione biosynthetic process,response to oxidative stress,aging,response to nutrient,apoptotic mitochondrial changes,response to heat,response to xenobiotic stimulus,response to hormone,response to activity,L-ascorbic acid metabolic process,negative regulation of protein ubiquitination,positive regulation of proteasomal ubiquitin-dependent protein catabolic process,cellular response to insulin stimulus,cellular response to hepatocyte growth factor stimulus,negative regulation of apoptotic process,negative regulation of neuron apoptotic process,cellular response to fibroblast growth factor stimulus,response to human chorionic gonadotropin,cell redox homeostasis,negative regulation of transcription, DNA-templated,response to arsenic-containing substance,response to cadmium ion,regulation of blood vessel size,response to nitrosative stress,regulation of mitochondrial depolarization,response to interleukin-1,cellular response to mechanical stimulus,cellular response to glucose stimulus,cellular response to follicle-stimulating hormone stimulus,cellular response to thyroxine stimulus,negative regulation of hepatic stellate cell activation,negative regulation of extrinsic apoptotic signaling pathwaymagnesium ion binding,glutamate-cysteine ligase activity,ATP binding,glutamate binding,ADP binding,protein heterodimerization activity,coenzyme binding)cytosol,glutamate-cysteine ligase complexl>sp|P48506|GSH1_HUMAN Glutamate--cysteine ligase catalytic subunit OS=Homo sapiens OX=9606 GN=GCLC PE=1 SV=2 P16298;Q08209 PPP3CB;PPP3CAPP2BB_HUMAN;PP2BA_HUMANSerine/threonine-protein phosphatase 2B catalytic subunit beta isoform;Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoformnegative regulation of T cell mediated cytotoxicity,lymphangiogenesis,protein phosphorylation,protein dephosphorylation,signal transduction,Wnt signaling pathway, calcium modulating pathway,heart development,learning,memory,dephosphorylation,calcium ion regulated exocytosis,T cell differentiation,locomotion involved in locomotory behavior,calcineurin-NFAT signaling cascade,response to cytokine,social behavior,cellular response to drug,positive regulation of insulin secretion involved in cellular response to glucose stimulus,Fc-epsilon receptor signaling pathway,T cell proliferation,T cell activation,T cell homeostasis,positive regulation of transcription, DNA-templated,positive regulation of transcription from RNA polymerase II promoter,regulation of synaptic plasticity,axon extension,regulation of insulin secretion,positive regulation of NFAT protein import into nucleus;G1/S transition of mitotic cell cycle,response to amphetamine,protein dephosphorylation,protein import into nucleus,calcium ion transport,Wnt signaling pathway, calcium modulating pathway,transition between fast and slow fiber,cardiac muscle hypertrophy in response to stress,dephosphorylation,calcineurin-NFAT signaling cascade,multicellular organismal response to stress,negative regulation of chromatin binding,cellular response to drug,Fc-epsilon receptor signaling pathway,T cell activation,positive regulation of transcription from RNA polymerase II promoter,negative regulation of insulin secretion,skeletal muscle fiber development,negative regulation of dendrite morphogenesis,modulation of synaptic transmission,positive regulation of sequence-specific DNA binding transcription factor activity,positive regulation of NFAT protein import into nucleus,response to calcium ion,excitatory postsynaptic potential,cellular response to glucose stimulus,positive regulation of cardiac muscle hypertrophy in response to stress,negative regulation of production of miRNAs involved in gene silencing by miRNA,positive regulation of connective tissue replacementprotein serine/threonine phosphatase activity,calcium ion binding,protein binding,calmodulin binding,drug binding,enzyme binding,protein phosphatase 2B binding,calmodulin-dependent protein phosphatase activity,protein dimerization activity;protein serine/threonine phosphatase activity,calcium ion binding,protein binding,calmodulin binding,drug binding,enzyme binding,calmodulin-dependent protein phosphatase activity,protein heterodimerization activity,protein dimerization activitynucleoplasm,cytosol,plasma membrane,calcineurin complex,Z disc,T-tubule;nucleoplasm,mitochondrion,cytosol,calcineurin complex,Z disc,sarcolemma,postsynapse>sp|P16298|PP2BB_HUMAN Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform OS=Homo sapiens OX=9606 GN=PPP3CB PE=1 SV=2;>sp|Q08209|PP2BA_HUMAN Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform OS=Homo sapiens OX=9606 GN=PPP3CA PE=1 SV=1P23470PTPRG PTPRG_HUMAN0Receptor-type tyrosine-protein phosphatase gammatransmembrane receptor protein tyrosine kinase signaling pathway,brain development,negative regulation of epithelial cell migration,negative regulation of neuron projection development,peptidyl-tyrosine dephosphorylation,regulation of homophilic cell adhesionprotein tyrosine phosphatase activity,transmembrane receptor protein tyrosine phosphatase activity,protein binding,identical protein bindingOextracellular space,integral component of plasma membrane,extracellular exosomer>sp|P23470|PTPRG_HUMAN Receptor-type tyrosine-protein phosphatase gamma OS=Homo sapiens OX=9606 GN=PTPRG PE=1 SV=4P46934NEDD4 NEDD4_HUMAN!E3 ubiquitin-protein ligase NEDD4adaptive immune response,outflow tract morphogenesis,endocardial cushion development,protein monoubiquitination,protein targeting to lysosome,lysosomal transport,neuromuscular junction development,negative regulation of sodium ion transport,negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage,positive regulation of phosphatidylinositol 3-kinase signaling,regulation of macroautophagy,protein ubiquitination,transmission of virus,negative regulation of vascular endothelial growth factor receptor signaling pathway,neuron projection development,receptor internalization,receptor catabolic process,cellular response to UV,regulation of ion transmembrane transport,T cell activation,regulation of membrane potential,protein ubiquitination involved in ubiquitin-dependent protein catabolic process,glucocorticoid receptor signaling pathway,ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway,development involved in symbiotic interaction,positive regulation of protein catabolic process,positive regulation of nucleocytoplasmic transport,blood vessel morphogenesis,regulation of dendrite morphogenesis,regulation of synapse organization,progesterone receptor signaling pathway,response to calcium ion,protein K63-linked ubiquitination,regulation of potassium ion transmembrane transporter activity,negative regulation of sodium ion transmembrane transporter activity0protein binding,sodium channel inhibitor activity,protein domain specific binding,beta-2 adrenergic receptor binding,ionotropic glutamate receptor binding,ubiquitin binding,phosphoserine binding,phosphothreonine binding,ubiquitin protein ligase activity,RNA polymerase binding,proline-rich region bindingubiquitin ligase complex,chromatin,cytoplasm,Golgi apparatus,cytosol,plasma membrane,cell cortex,apicolateral plasma membrane,dendritic spine,perinuclear region of cytoplasm,extracellular exosomec>sp|P46934|NEDD4_HUMAN E3 ubiquitin-protein ligase NEDD4 OS=Homo sapiens OX=9606 GN=NEDD4 PE=1 SV=4P35030PRSS3 TRY3_HUMAN< Trypsin-3proteolysis,digestion,cobalamin metabolic process,antimicrobial humoral response,zymogen activation,neutrophil degranulation,endothelial cell migrationUextracellular region,extracellular space,extracellular exosome,tertiary granule lumenJ>sp|P35030|TRY3_HUMAN Trypsin-3 OS=Homo sapiens OX=9606 GN=PRSS3 PE=1 SV=2O95816BAG2 BAG2_HUMAN*BAG family molecular chaperone regulator 2rprotein folding,protein metabolic process,regulation of catalytic activity,regulation of cellular response to heatfadenyl-nucleotide exchange factor activity,protein binding,identical protein binding,chaperone bindingj>sp|O95816|BAG2_HUMAN BAG family molecular chaperone regulator 2 OS=Homo sapiens OX=9606 GN=BAG2 PE=1 SV=1Q7L5N1COPS6 CSN6_HUMAN"COP9 signalosome complex subunit 6protein deneddylation,nucleotide-excision repair, DNA damage recognition,transcription-coupled nucleotide-excision repair,viral process:nucleoplasm,cytosol,COP9 signalosome,extracellular exosomec>sp|Q7L5N1|CSN6_HUMAN COP9 signalosome complex subunit 6 OS=Homo sapiens OX=9606 GN=COPS6 PE=1 SV=1P51153RAB13 RAB13_HUMANRas-related protein Rab-13small GTPase mediated signal transduction,protein kinase A signaling,protein transport,endosomal transport,cortical actin cytoskeleton organization,neuron projection development,endocytic recycling,cellular response to insulin stimulus,endothelial cell chemotaxis,trans-Golgi network to recycling endosome transport,membrane organization,bicellular tight junction assembly,establishment of protein localization to plasma membrane,establishment of Sertoli cell barrier,protein localization to cell leading edgeVGTPase activity,protein binding,GTP binding,protein kinase A catalytic subunit bindingBtrans-Golgi network,cytosol,plasma membrane,bicellular tight junction,lateral plasma membrane,lamellipodium,cell junction,endocytic vesicle,cytoplasmic vesicle membrane,cytoplasmic vesicle,insulin-responsive compartment,neuron projection,recycling endosome,recycling endosome membrane,extracellular exosome,Golgi apparatus\>sp|P51153|RAB13_HUMAN Ras-related protein Rab-13 OS=Homo sapiens OX=9606 GN=RAB13 PE=1 SV=1P61586RHOA RHOA_HUMANTransforming protein RhoA/transforming growth factor beta receptor signaling pathway,Rho protein signal transduction,viral process,cell migration,protein deubiquitination,substantia nigra development,actin cytoskeleton organization,platelet activation,regulation of cell migration,actin cytoskeleton reorganization,positive regulation of cytokinesis,regulation of actin cytoskeleton organization,regulation of osteoblast proliferation,Roundabout signaling pathway,cleavage furrow formation,apolipoprotein A-I-mediated signaling pathway,positive regulation of NF-kappaB import into nucleus,positive regulation of I-kappaB kinase/NF-kappaB signaling,stress fiber assembly,apical junction assembly,neutrophil degranulation,endothelial cell migration,ossification involved in bone maturation,wound healing, spreading of cells,positive regulation of neuron differentiation,vascular endothelial growth factor receptor signaling pathway,ephrin receptor signaling pathway,phosphatidylinositol-mediated signaling,negative regulation of axonogenesis,positive regulation of axonogenesis,negative chemotaxis,regulation of small GTPase mediated signal transduction,positive regulation of stress fiber assembly,Wnt signaling pathway, planar cell polarity pathway,positive regulation of lipase activity,trabecula morphogenesis,positive regulation of protein serine/threonine kinase activity,negative regulation of cell migration involved in sprouting angiogenesis,mitotic spindle assembly,endothelial tube lumen extension,skeletal muscle satellite cell migration,mitotic cleavage furrow formation,regulation of cell motility:GTPase activity,protein binding,GTP binding,myosin bindingfendosome,endoplasmic reticulum membrane,cytosol,cytoskeleton,plasma membrane,focal adhesion,cell cortex,lamellipodium,cell junction,midbody,secretory granule membrane,extrinsic component of cytoplasmic side of plasma membrane,vesicle,dendritic spine,apical junction complex,extracellular exosome,cell periphery,ficolin-1-rich granule membrane,cleavage furrowY>sp|P61586|RHOA_HUMAN Transforming protein RhoA OS=Homo sapiens OX=9606 GN=RHOA PE=1 SV=1P42356PI4KA PI4KA_HUMAN#Phosphatidylinositol 4-kinase alphaphosphatidylinositol biosynthetic process,signal transduction,phosphorylation,viral RNA genome replication,multi-organism membrane organization,viral replication complex formation and maintenance,phosphatidylinositol phosphorylation,phosphatidylinositol-mediated signalinge1-phosphatidylinositol 4-kinase activity,protein binding,ATP binding,kinase activity,cadherin bindingcytoplasm,cytosol,plasma membrane,focal adhesion,membrane,viral replication complex,Golgi-associated vesicle membrane,extracellular exosomee>sp|P42356|PI4KA_HUMAN Phosphatidylinositol 4-kinase alpha OS=Homo sapiens OX=9606 GN=PI4KA PE=1 SV=4Q13867BLMH BLMH_HUMANBleomycin hydrolaserprotein polyubiquitination,proteolysis,response to toxic substance,response to drug,homocysteine catabolic processaminopeptidase activity,carboxypeptidase activity,cysteine-type endopeptidase activity,protein binding,cysteine-type peptidase activity,identical protein bindingS>sp|Q13867|BLMH_HUMAN Bleomycin hydrolase OS=Homo sapiens OX=9606 GN=BLMH PE=1 SV=1Q9HB90RRAGC RRAGC_HUMAN!Ras-related GTP-binding protein CUtranscription, DNA-templated,apoptotic process,cell cycle arrest,small GTPase mediated signal transduction,RNA splicing,cell growth,macroautophagy,regulation of TOR signaling,cellular response to amino acid starvation,cellular protein localization,response to amino acid,cellular response to amino acid stimulus,regulation of TORC1 signalingqmagnesium ion binding,GTPase activity,protein binding,GTP binding,GDP binding,protein heterodimerization activityKnucleus,cytoplasm,lysosome,cytosol,intracellular membrane-bounded organellec>sp|Q9HB90|RRAGC_HUMAN Ras-related GTP-binding protein C OS=Homo sapiens OX=9606 GN=RRAGC PE=1 SV=1Q01650SLC7A5 LAT1_HUMAN5Large neutral amino acids transporter small subunit 1cellular amino acid metabolic process,tryptophan catabolic process,transport,amino acid transport,nervous system development,neutral amino acid transport,cell differentiation,leukocyte migration,L-alpha-amino acid transmembrane transportamino acid transmembrane transporter activity,neutral amino acid transmembrane transporter activity,L-amino acid transmembrane transporter activity,antiporter activity,peptide antigen bindingcytosol,plasma membrane,integral component of plasma membrane,membrane,apical plasma membrane,intracellular membrane-bounded organelle,extracellular exosomew>sp|Q01650|LAT1_HUMAN Large neutral amino acids transporter small subunit 1 OS=Homo sapiens OX=9606 GN=SLC7A5 PE=1 SV=2P31947SFN 1433S_HUMAN14-3-3 protein sigmaregulation of cyclin-dependent protein serine/threonine kinase activity,release of cytochrome c from mitochondria,keratinocyte development,negative regulation of protein kinase activity,DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest,signal transduction,intrinsic apoptotic signaling pathway in response to DNA damage,regulation of epidermal cell division,negative regulation of keratinocyte proliferation,positive regulation of cell growth,keratinization,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process,positive regulation of epidermal cell differentiation,positive regulation of protein export from nucleus,membrane organization,establishment of skin barrier,negative regulation of protein serine/threonine kinase activity,positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayprotein binding,protein kinase C inhibitor activity,protein kinase binding,protein domain specific binding,identical protein binding,cadherin binding,phosphoprotein bindingdextracellular space,nucleus,mitochondrion,cytosol,cytoplasmic vesicle membrane,extracellular exosome< T>sp|P31947|1433S_HUMAN 14-3-3 protein sigma OS=Homo sapiens OX=9606 GN=SFN PE=1 SV=1Q9UEU0VTI1B VTI1B_HUMAN>Vesicle transport through interaction with t-SNAREs homolog 1Bplatelet degranulation,protein targeting to vacuole,ER to Golgi vesicle-mediated transport,intra-Golgi vesicle-mediated transport,Golgi to vacuole transport,vesicle docking involved in exocytosis,cell proliferation,vesicle-mediated transport,retrograde transport, endosome to Golgi,vesicle fusion with Golgi apparatus,membrane fusion,regulation of molecular function,regulation of protein localization to plasma membrane,autophagosome maturationXSNARE binding,SNAP receptor activity,protein binding,chloride channel inhibitor activityextracellular region,lysosomal membrane,endoplasmic reticulum membrane,Golgi apparatus,cytosol,synaptic vesicle,ER to Golgi transport vesicle membrane,integral component of membrane,platelet alpha granule lumen,SNARE complex,early endosome membrane,late endosome membrane,vesicle,neuronal cell body,intracellular membrane-bounded organelle,perinuclear region of cytoplasm,recycling endosome,recycling endosome membrane>sp|Q9UEU0|VTI1B_HUMAN Vesicle transport through interaction with t-SNAREs homolog 1B OS=Homo sapiens OX=9606 GN=VTI1B PE=1 SV=3P60520 GABARAPL2 GBRL2_HUMAN:Gamma-aminobutyric acid receptor-associated protein-like 2intra-Golgi vesicle-mediated transport,autophagy,protein transport,macroautophagy,positive regulation of ATPase activity,membrane organization,autophagosome maturation,negative regulation of proteasomal protein catabolic processSNARE binding,protein binding,microtubule binding,ubiquitin protein ligase binding,beta-tubulin binding,GABA receptor binding,ATPase bindingwGolgi membrane,autophagosome membrane,intracellular,cytoplasm,autophagosome,Golgi apparatus,cytosol,cytoplasmic vesicle>sp|P60520|GBRL2_HUMAN Gamma-aminobutyric acid receptor-associated protein-like 2 OS=Homo sapiens OX=9606 GN=GABARAPL2 PE=1 SV=1P26599PTBP1 PTBP1_HUMAN&Polypyrimidine tract-binding protein 1alternative mRNA splicing, via spliceosome,regulation of alternative mRNA splicing, via spliceosome,mRNA splicing, via spliceosome,mRNA processing,RNA splicing,fibroblast growth factor receptor signaling pathway,gene expression,negative regulation of RNA splicing,negative regulation of mRNA splicing, via spliceosome,negative regulation of muscle cell differentiation,IRES-dependent viral translational initiation]nucleotide binding,RNA binding,protein binding,poly-pyrimidine tract binding,pre-mRNA binding4nucleoplasm,nucleolus,membrane,extracellular exosomeh>sp|P26599|PTBP1_HUMAN Polypyrimidine tract-binding protein 1 OS=Homo sapiens OX=9606 GN=PTBP1 PE=1 SV=1Q14847LASP1 LASP1_HUMANLIM and SH3 domain protein 1Tion transport,positive regulation of signal transduction,ion transmembrane transportSH3/SH2 adaptor activity,protein binding,zinc ion binding,ion transmembrane transporter activity,cadherin binding,actin filament bindingJcytoplasm,focal adhesion,cortical actin cytoskeleton,extracellular exosome^>sp|Q14847|LASP1_HUMAN LIM and SH3 domain protein 1 OS=Homo sapiens OX=9606 GN=LASP1 PE=1 SV=2P08174CD55 DAF_HUMAN$Complement decay-accelerating factor/ER to Golgi vesicle-mediated transport,complement activation, classical pathway,positive regulation of cytosolic calcium ion concentration,regulation of complement activation,regulation of lipopolysaccharide-mediated signaling pathway,CD4-positive, alpha-beta T cell cytokine production,neutrophil degranulation,innate immune response,respiratory burst,negative regulation of complement activation,viral entry into host cell,positive regulation of CD4-positive, alpha-beta T cell activation,positive regulation of CD4-positive, alpha-beta T cell proliferation5virus receptor activity,protein binding,lipid binding4Golgi membrane,extracellular region,plasma membrane,integral component of plasma membrane,cell surface,transport vesicle,secretory granule membrane,anchored component of membrane,endoplasmic reticulum-Golgi intermediate compartment membrane,membrane raft,extracellular exosome,ficolin-1-rich granule membranec>sp|P08174|DAF_HUMAN Complement decay-accelerating factor OS=Homo sapiens OX=9606 GN=CD55 PE=1 SV=4P10586;P23468;Q13332PTPRF;PTPRD;PTPRS#PTPRF_HUMAN;PTPRD_HUMAN;PTPRS_HUMANReceptor-type tyrosine-protein phosphatase F;Receptor-type tyrosine-protein phosphatase delta;Receptor-type tyrosine-protein phosphatase Scell adhesion,transmembrane receptor protein tyrosine phosphatase signaling pathway,cell migration,neuron projection regeneration,peptidyl-tyrosine dephosphorylation,regulation of axon regeneration,negative regulation of receptor binding;protein dephosphorylation,phosphate-containing compound metabolic process,heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules,transmembrane receptor protein tyrosine phosphatase signaling pathway,neuron differentiation,peptidyl-tyrosine dephosphorylation,positive regulation of dendrite morphogenesis,presynaptic membrane assembly;protein dephosphorylation,cell adhesion,negative regulation of neuron projection development,spinal cord development,cerebellum development,hippocampus development,cerebral cortex development,corpus callosum development,negative regulation of axon extension,negative regulation of interferon-alpha production,negative regulation of interferon-beta production,negative regulation of toll-like receptor 9 signaling pathway,peptidyl-tyrosine dephosphorylation,negative regulation of collateral sprouting,negative regulation of axon regeneration,negative regulation of dendritic spine development,establishment of endothelial intestinal barrierprotein tyrosine phosphatase activity,transmembrane receptor protein tyrosine phosphatase activity,heparin binding,protein complex binding,chondroitin sulfate proteoglycan binding;transmembrane receptor protein tyrosine phosphatase activity,receptor binding,protein binding,cell adhesion molecule binding;phosphoprotein phosphatase activity,protein tyrosine phosphatase activity,protein binding,heparin binding,chondroitin sulfate binding,heparan sulfate proteoglycan bindingqplasma membrane,integral component of plasma membrane,neuron projection,neuronal cell body,extracellular exosome;plasma membrane,integral component of plasma membrane,extracellular exosome;plasma membrane,integral component of plasma membrane,integral component of synaptic vesicle membrane,axon,extracellular exosome,integral component of postsynaptic density membraneP>sp|P10586|PTPRF_HUMAN Receptor-type tyrosine-protein phosphatase F OS=Homo sapiens OX=9606 GN=PTPRF PE=1 SV=2;>sp|P23468|PTPRD_HUMAN Receptor-type tyrosine-protein phosphatase delta OS=Homo sapiens OX=9606 GN=PTPRD PE=1 SV=2;>sp|Q13332|PTPRS_HUMAN Receptor-type tyrosine-protein phosphatase S OS=Homo sapiens OX=9606 GN=PTPRS PE=1 SV=3A0FGR8ESYT2 ESYT2_HUMANExtended synaptotagmin-2?glycosphingolipid metabolic process,lipid transport,endocytosiscalcium ion binding,protein binding,calcium-dependent phospholipid binding,phosphatidylethanolamine binding,phosphatidylcholine binding,phosphatidylinositol binding,identical protein binding,cadherin bindingendoplasmic reticulum membrane,integral component of plasma membrane,membrane,intrinsic component of endoplasmic reticulum membrane,extrinsic component of cytoplasmic side of plasma membrane,organelle membrane contact siteZ>sp|A0FGR8|ESYT2_HUMAN Extended synaptotagmin-2 OS=Homo sapiens OX=9606 GN=ESYT2 PE=1 SV=1Q06323PSME1 PSME1_HUMAN&Proteasome activator complex subunit 10protein binding,endopeptidase activator activitycproteasome complex,nucleoplasm,cytoplasm,cytosol,proteasome activator complex,extracellular exosomeh>sp|Q06323|PSME1_HUMAN Proteasome activator complex subunit 1 OS=Homo sapiens OX=9606 GN=PSME1 PE=1 SV=1P12236SLC25A6 ADT3_HUMANADP/ATP translocase 3protein targeting to mitochondrion,apoptotic process,adenine transport,ADP transport,ATP transport,active induction of host immune response by virus,regulation of mitochondrial membrane permeability,regulation of insulin secretion< ,transmembrane transportVATP:ADP antiporter activity,protein binding,adenine transmembrane transporter activitynucleus,mitochondrion,mitochondrial inner membrane,mitochondrial inner membrane presequence translocase complex,integral component of membrane,extracellular matrixX>sp|P12236|ADT3_HUMAN ADP/ATP translocase 3 OS=Homo sapiens OX=9606 GN=SLC25A6 PE=1 SV=4O95336PGLS 6PGL_HUMAN6-phosphogluconolactonase`carbohydrate metabolic process,pentose-phosphate shunt,pentose-phosphate shunt, oxidative branch2protein binding,6-phosphogluconolactonase activityY>sp|O95336|6PGL_HUMAN 6-phosphogluconolactonase OS=Homo sapiens OX=9606 GN=PGLS PE=1 SV=2P10619CTSA PPGB_HUMANLysosomal protective proteinLproteolysis,glycosphingolipid metabolic process,intracellular protein transport,regulation of protein stability,positive regulation of catalytic activity,neutrophil degranulation,proteolysis involved in cellular protein catabolic process,regulation of chaperone-mediated autophagy,negative regulation of chaperone-mediated autophagyvcarboxypeptidase activity,serine-type carboxypeptidase activity,exo-alpha-sialidase activity,enzyme activator activityextracellular region,nucleoplasm,lysosome,endoplasmic reticulum,membrane,azurophil granule lumen,lysosomal lumen,intracellular membrane-bounded organelle,extracellular exosome,lumenal side of lysosomal membrane\>sp|P10619|PPGB_HUMAN Lysosomal protective protein OS=Homo sapiens OX=9606 GN=CTSA PE=1 SV=2Q5T750XP32 XP32_HUMANSkin-specific protein 32Hepidermis development,peptide cross-linking,keratinocyte differentiation/molecular_function,structural molecule activity2cornified envelope,cytoplasm,extracellular exosomeX>sp|Q5T750|XP32_HUMAN Skin-specific protein 32 OS=Homo sapiens OX=9606 GN=XP32 PE=1 SV=1P10599TXN THIO_HUMAN Thioredoxinnegative regulation of transcription from RNA polymerase II promoter,response to reactive oxygen species,transcription, DNA-templated,glycerol ether metabolic process,movement of cell or subcellular component,signal transduction,cell-cell signaling,cell proliferation,response to radiation,nucleobase-containing small molecule interconversion,protein repair,activation of protein kinase B activity,positive regulation of peptidyl-serine phosphorylation,regulation of protein import into nucleus, translocation,positive regulation of DNA binding,cell redox homeostasis,negative regulation of protein export from nucleus,positive regulation of protein kinase B signaling,oxidation-reduction process,cellular oxidant detoxification,negative regulation of hydrogen peroxide-induced cell deathRNA binding,thioredoxin-disulfide reductase activity,protein binding,protein disulfide oxidoreductase activity,peptide disulfide oxidoreductase activity,oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor,protein-disulfide reductase activity=nucleus,cytoplasm,mitochondrion,cytosol,extracellular exosomeJ>sp|P10599|THIO_HUMAN Thioredoxin OS=Homo sapiens OX=9606 GN=TXN PE=1 SV=3 P38159;Q96E39 RBMX;RBMXL1RBMX_HUMAN;RMXL1_HUMANRRNA-binding motif protein, X chromosome;RNA binding motif protein, X-linked-like-1regulation of alternative mRNA splicing, via spliceosome,mRNA splicing, via spliceosome,osteoblast differentiation,transcription from RNA polymerase II promoter,mRNA splice site selection,membrane protein ectodomain proteolysis,gene expression,positive regulation of transcription from RNA polymerase II promoter,negative regulation of mRNA splicing, via spliceosome,positive regulation of mRNA splicing, via spliceosome,protein homooligomerization,cellular response to interleukin-1;mRNA processing,RNA splicingnucleotide binding,core promoter binding,chromatin binding,RNA binding,single-stranded RNA binding,mRNA binding,protein binding,identical protein binding;nucleotide binding,RNA bindingextracellular space,nucleus,nucleoplasm,nuclear euchromatin,membrane,intracellular ribonucleoprotein complex,supraspliceosomal complex,extracellular exosome,catalytic step 2 spliceosome;nucleus,intracellular ribonucleoprotein complex3;1>sp|P38159|RBMX_HUMAN RNA-binding motif protein, X chromosome OS=Homo sapiens OX=9606 GN=RBMX PE=1 SV=3;>sp|Q96E39|RMXL1_HUMAN RNA binding motif protein, X-linked-like-1 OS=Homo sapiens OX=9606 GN=RBMXL1 PE=1 SV=1Q13530SERINC3 SERC3_HUMANSerine incorporator 3L-serine biosynthetic process,phosphatidylserine metabolic process,sphingolipid metabolic process,detection of virus,L-serine transport,innate immune response,defense response to virus,positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwayIL-serine transmembrane transporter activity,L-serine transporter activity]Golgi membrane,plasma membrane,integral component of membrane,perinuclear region of cytoplasmY>sp|Q13530|SERC3_HUMAN Serine incorporator 3 OS=Homo sapiens OX=9606 GN=SERINC3 PE=1 SV=2P36543ATP6V1E1 VATE1_HUMAN V-type proton ATPase subunit E 1protein binding,hydrogen-exporting ATPase activity, phosphorylative mechanism,proton-transporting ATPase activity, rotational mechanism,ATPase bindingmitochondrion,lysosomal membrane,endosome,cytosol,microvillus,apical plasma membrane,proton-transporting two-sector ATPase complex,proton-transporting two-sector ATPase complex, catalytic domain,extracellular exosomee>sp|P36543|VATE1_HUMAN V-type proton ATPase subunit E 1 OS=Homo sapiens OX=9606 GN=ATP6V1E1 PE=1 SV=1O75084FZD7 FZD7_HUMAN Frizzled-7regulation of transcription, DNA-templated,G-protein coupled receptor signaling pathway,negative regulation of cell-substrate adhesion,skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration,stem cell population maintenance,neuron differentiation,T cell differentiation in thymus,substrate adhesion-dependent cell spreading,regulation of catenin import into nucleus,non-canonical Wnt signaling pathway via JNK cascade,positive regulation of phosphorylation,negative regulation of ectodermal cell fate specification,positive regulation of transcription, DNA-templated,positive regulation of JNK cascade,somatic stem cell division,positive regulation of epithelial cell proliferation involved in wound healing,canonical Wnt signaling pathway,Wnt signaling pathway, planar cell polarity pathway,mesenchymal to epithelial transition,cellular response to retinoic acid,negative regulation of cardiac muscle cell differentiationG-protein coupled receptor activity,frizzled binding,protein binding,phosphatidylinositol-4,5-bisphosphate binding,Wnt-protein binding,PDZ domain binding,Wnt-activated receptor activityJplasma membrane,integral component of membrane,recycling endosome membraneJ>sp|O75084|FZD7_HUMAN Frizzled-7 OS=Homo sapiens OX=9606 GN=FZD7 PE=1 SV=2Q9NP72RAB18 RAB18_HUMANRas-related protein Rab-18eye development,small GTPase mediated signal transduction,brain development,protein transport,lipid particle organization,neutrophil degranulation,membrane organization,endoplasmic reticulum tubular network organization,single-organism nuclear importintracellular,endoplasmic reticulum membrane,cytosol,plasma membrane,secretory granule membrane,extracellular exosome,endoplasmic reticulum tubular network\>sp|Q9NP72|RAB18_HUMAN Ras-related protein Rab-18 OS=Homo sapiens OX=9606 GN=RAB18 PE=1 SV=1Q96KP4CNDP2 CNDP2_HUMAN"Cytosolic non-specific dipeptidasePsulfur amino acid metabolic process,proteolysis,glutathione biosynthetic processvcarboxypeptidase activity,metallopeptidase activity,metal ion binding,cytosolic dipeptidase activity,Requires Ontologyd>sp|Q96KP4|CNDP2_HUMAN Cytosolic non-specific dipeptidase OS=Homo sapiens OX=9606 GN=CNDP2 PE=1 SV=2Q9BS26ERP44 ERP44_HUMAN)Endoplasmic reticulum resident protein 44protein folding,response to unfolded protein,glycoprotein metabolic process,response to endoplasmic reticulum stress,neutrophil degranulation,cell redox homeostasisextracellular region,endoplasmic reticulum lumen,endoplasmic reticulum membrane,endoplasmic reticulum-Golgi intermediate compartment,cell surface,specific granule lumen,extracellul< ar exosomek>sp|Q9BS26|ERP44_HUMAN Endoplasmic reticulum resident protein 44 OS=Homo sapiens OX=9606 GN=ERP44 PE=1 SV=1P62314SNRPD1 SMD1_HUMAN%Small nuclear ribonucleoprotein Sm D1tspliceosomal complex assembly,spliceosomal snRNP assembly,mRNA splicing, via spliceosome,RNA splicing,nuclear import,RNA binding,protein binding,U1 snRNP binding8commitment complex,nucleus,nucleoplasm,U5 snRNP,U1 snRNP,U2 snRNP,U4 snRNP,U12-type spliceosomal complex,cytosol,small nuclear ribonucleoprotein complex,methylosome,pICln-Sm protein complex,SMN-Sm protein complex,prespliceosome,precatalytic spliceosome,catalytic step 2 spliceosome,spliceosomal tri-snRNP complexg>sp|P62314|SMD1_HUMAN Small nuclear ribonucleoprotein Sm D1 OS=Homo sapiens OX=9606 GN=SNRPD1 PE=1 SV=1P52565ARHGDIA GDIR1_HUMAN Rho GDP-dissociation inhibitor 1movement of cell or subcellular component,negative regulation of cell adhesion,regulation of Rho protein signal transduction,negative regulation of apoptotic process,positive regulation of GTPase activity,negative regulation of axonogenesis,positive regulation of axonogenesis,regulation of small GTPase mediated signal transduction,semaphorin-plexin signaling pathway,regulation of actin cytoskeleton reorganizationQRho GDP-dissociation inhibitor activity,GTPase activator activity,protein binding*cytosol,cytoskeleton,extracellular exosomed>sp|P52565|GDIR1_HUMAN Rho GDP-dissociation inhibitor 1 OS=Homo sapiens OX=9606 GN=ARHGDIA PE=1 SV=3P14314PRKCSH GLU2B_HUMANGlucosidase 2 subunit betaEprotein folding,N-glycan processing,intracellular signal transductionWprotein kinase C binding,calcium ion binding,ion channel binding,phosphoprotein binding?intracellular,endoplasmic reticulum,endoplasmic reticulum lumen]>sp|P14314|GLU2B_HUMAN Glucosidase 2 subunit beta OS=Homo sapiens OX=9606 GN=PRKCSH PE=1 SV=2P62942FKBP1A FKB1A_HUMAN*Peptidyl-prolyl cis-trans isomerase FKBP1Aprotein peptidyl-prolyl isomerization,heart morphogenesis,protein folding,'de novo' protein folding,transforming growth factor beta receptor signaling pathway,SMAD protein complex assembly,protein maturation by protein folding,positive regulation of protein ubiquitination,positive regulation of protein binding,negative regulation of phosphoprotein phosphatase activity,regulation of protein localization,regulation of activin receptor signaling pathway,protein refolding,T cell activation,positive regulation of I-kappaB kinase/NF-kappaB signaling,regulation of immune response,ventricular cardiac muscle tissue morphogenesis,regulation of ryanodine-sensitive calcium-release channel activity,heart trabecula formation,chaperone-mediated protein folding,calcium ion transmembrane transport,fibril organization,regulation of amyloid precursor protein catabolic process,amyloid fibril formation,negative regulation of release of sequestered calcium ion into cytosol,negative regulation of ryanodine-sensitive calcium-release channel activity4peptidyl-prolyl cis-trans isomerase activity,signal transducer activity,transforming growth factor beta receptor binding,protein binding,macrolide binding,FK506 binding,type I transforming growth factor beta receptor binding,ion channel binding,SMAD binding,activin binding,calcium channel inhibitor activityIcytoplasm,cytosol,terminal cisterna,membrane,Z disc,extracellular exosomem>sp|P62942|FKB1A_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP1A OS=Homo sapiens OX=9606 GN=FKBP1A PE=1 SV=2P01116KRAS RASK_HUMAN GTPase KRasMAPK cascade,liver development,positive regulation of protein phosphorylation,stimulatory C-type lectin receptor signaling pathway,epidermal growth factor receptor signaling pathway,Ras protein signal transduction,axon guidance,female pregnancy,positive regulation of cell proliferation,visual learning,positive regulation of gene expression,cytokine-mediated signaling pathway,forebrain astrocyte development,actin cytoskeleton organization,regulation of protein stability,regulation of synaptic transmission, GABAergic,positive regulation of Rac protein signal transduction,response to isolation stress,endocrine signaling,Fc-epsilon receptor signaling pathway,ERBB2 signaling pathway,positive regulation of MAP kinase activity,negative regulation of neuron apoptotic process,negative regulation of cell differentiation,regulation of long-term neuronal synaptic plasticity,homeostasis of number of cells within a tissue,leukocyte migration,positive regulation of nitric-oxide synthase activity,positive regulation of NF-kappaB transcription factor activity,striated muscle cell differentiation,response to glucocorticoid,response to mineralocorticoid,epithelial tube branching involved in lung morphogenesis,positive regulation of cellular senescencenGTPase activity,protein binding,GTP binding,GMP binding,GDP binding,LRR domain binding,protein complex bindingcytoplasm,mitochondrion,cytosol,plasma membrane,focal adhesion,membrane,extrinsic component of cytoplasmic side of plasma membrane,membrane raftK>sp|P01116|RASK_HUMAN GTPase KRas OS=Homo sapiens OX=9606 GN=KRAS PE=1 SV=1Q8IWB7WDFY1 WDFY1_HUMAN.WD repeat and FYVE domain-containing protein 1biological_process,positive regulation of toll-like receptor 3 signaling pathway,positive regulation of toll-like receptor 4 signaling pathway?protein binding,1-phosphatidylinositol binding,zinc ion bindingnucleus,early endosome,cytosolp>sp|Q8IWB7|WDFY1_HUMAN WD repeat and FYVE domain-containing protein 1 OS=Homo sapiens OX=9606 GN=WDFY1 PE=1 SV=1Q15517CDSN CDSN_HUMANCorneodesmosincell adhesion,epidermis development,single organismal cell-cell adhesion,keratinocyte differentiation,skin morphogenesis,cornificationUcornified envelope,plasma membrane,cell-cell junction,desmosome,extracellular exosomeN>sp|Q15517|CDSN_HUMAN Corneodesmosin OS=Homo sapiens OX=9606 GN=CDSN PE=1 SV=3Q9NP79VTA1 VTA1_HUMAN8Vacuolar protein sorting-associated protein VTA1 homologprotein transport,endosomal transport,macroautophagy,viral life cycle,multivesicular body assembly,viral budding,multivesicular body sorting pathway,ESCRT III complex disassembly*protein binding,protein C-terminus bindingdnucleoplasm,cytosol,endosome membrane,intracellular membrane-bounded organelle,extracellular exosomex>sp|Q9NP79|VTA1_HUMAN Vacuolar protein sorting-associated protein VTA1 homolog OS=Homo sapiens OX=9606 GN=VTA1 PE=1 SV=1P04080CSTB CYTB_HUMAN Cystatin-Badult locomotory behavior,negative regulation of peptidase activity,negative regulation of endopeptidase activity,neutrophil degranulation,negative regulation of proteolysislprotease binding,RNA binding,endopeptidase inhibitor activity,cysteine-type endopeptidase inhibitor activityextracellular region,extracellular space,nucleolus,cytoplasm,cytosol,secretory granule lumen,extracellular exosome,tertiary granule lumen,ficolin-1-rich granule lumenJ>sp|P04080|CYTB_HUMAN Cystatin-B OS=Homo sapiens OX=9606 GN=CSTB PE=1 SV=2Q07021C1QBP C1QBP_HUMANDComplement component 1 Q subcomponent-binding protein, mitochondrial%negative regulation of transcription from RNA polymerase II promoter,transcription, DNA-templated,mRNA processing,apoptotic process,immune response,complement activation, classical pathway,blood coagulation, intrinsic pathway,RNA splicing,phosphatidylinositol 3-kinase signaling,viral process,regulation of complement activation,negative regulation of interferon-gamma production,negative regulation of interleukin-12 production,negative regulation of MDA-5 signaling pathway,negative regulation of RIG-I signaling pathway,mature ribosome assembly,positive regulation of apoptotic process,innate immune response,positive regulation of cell adhesion,negative regulation of mRNA splicing, via spliceosome,negative regulation of defense response to virus,positive regulation of protein kinase B signaling,positive regulation of mitochondrial translation,positive regulation of neutrophil chemotaxis,positive regulation of substrate adhesion-dependent cell spreading,positive regulation of trophoblast cell migration,positive regulation of dendritic cell chemotaxiscomplement< component C1q binding,transcription corepressor activity,mRNA binding,protein kinase C binding,protein binding,hyaluronic acid binding,transcription factor binding,kininogen binding,adrenergic receptor binding,mitochondrial ribosome bindingextracellular space,nucleus,nucleolus,cytoplasm,mitochondrion,mitochondrial matrix,cytosol,plasma membrane,cell surface,membrane>sp|Q07021|C1QBP_HUMAN Complement component 1 Q subcomponent-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=C1QBP PE=1 SV=1Q86YZ3HRNR HORN_HUMANHornerin`keratinization,cell envelope organization,neutrophil degranulation,establishment of skin barrier0calcium ion binding,transition metal ion bindingcornified envelope,extracellular region,nucleus,cytoplasm,cell envelope,azurophil granule lumen,keratohyalin granule,perinuclear region of cytoplasm,extracellular exosomeH>sp|Q86YZ3|HORN_HUMAN Hornerin OS=Homo sapiens OX=9606 GN=HRNR PE=1 SV=2Q9UNK0STX8 STX8_HUMAN Syntaxin-8transport,intracellular protein transport,vesicle fusion,endosome to lysosome transport,early endosome to late endosome transport,vesicle docking,regulation of molecular function,regulation of protein localization to plasma membrane|SNAP receptor activity,protein binding,chloride channel inhibitor activity,syntaxin binding,ubiquitin protein ligase bindinglysosomal membrane,endosome,early endosome,late endosome,endoplasmic reticulum,trans-Golgi network,cytosol,integral component of plasma membrane,SNARE complex,late endosome membrane,vesicle,perinuclear region of cytoplasm,recycling endosomeJ>sp|Q9UNK0|STX8_HUMAN Syntaxin-8 OS=Homo sapiens OX=9606 GN=STX8 PE=1 SV=2O95865DDAH2 DDAH2_HUMAN3N(G),N(G)-dimethylarginine dimethylaminohydrolase 2citrulline metabolic process,arginine catabolic process,nitric oxide biosynthetic process,nitric oxide mediated signal transduction,negative regulation of apoptotic process,positive regulation of nitric oxide biosynthetic process,regulation of nitric-oxide synthase activityQcatalytic activity,protein binding,dimethylargininase activity,amino acid bindingImitochondrion,microtubule organizing center,cytosol,extracellular exosomeu>sp|O95865|DDAH2_HUMAN N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 OS=Homo sapiens OX=9606 GN=DDAH2 PE=1 SV=1P30626SRI SORCN_HUMANSorcinaction potential,proteolysis,transport,calcium ion transport,intracellular sequestering of iron ion,regulation of striated muscle contraction,signal transduction,heart development,muscle organ development,regulation of heart contraction,negative regulation of heart rate,regulation of cell communication by electrical coupling,regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum,positive regulation of insulin secretion involved in cellular response to glucose stimulus,cytoplasmic sequestering of transcription factor,positive regulation of release of sequestered calcium ion into cytosol,regulation of calcium ion transport,negative regulation of ryanodine-sensitive calcium-release channel activity,regulation of cardiac muscle cell contraction,regulation of relaxation of muscle,regulation of high voltage-gated calcium channel activity,regulation of cell communication by electrical coupling involved in cardiac conduction,negative regulation of transcription regulatory region DNA bindingprotease binding,calcium-dependent cysteine-type endopeptidase activity,receptor binding,calcium channel regulator activity,calcium ion binding,protein binding,ion channel binding,protein heterodimerization activity,repressing transcription factor bindingnucleoplasm,cytoplasm,mitochondrion,endoplasmic reticulum membrane,smooth endoplasmic reticulum,cytosol,membrane,sarcoplasmic reticulum,Z disc,T-tubule,axon,sarcoplasmic reticulum membrane,axon terminus,dendritic spine neck,extracellular exosome,chromaffin granule membraneF>sp|P30626|SORCN_HUMAN Sorcin OS=Homo sapiens OX=9606 GN=SRI PE=1 SV=1P02765AHSG FETUA_HUMANAlpha-2-HS-glycoproteinskeletal system development,ossification,platelet degranulation,pinocytosis,acute-phase response,negative regulation of endopeptidase activity,regulation of bone mineralization,negative regulation of bone mineralization,negative regulation of phosphorylation,neutrophil degranulation,negative regulation of insulin receptor signaling pathway,regulation of inflammatory response,positive regulation of phagocytosis,negative regulation of biomineral tissue developmentiendopeptidase inhibitor activity,cysteine-type endopeptidase inhibitor activity,kinase inhibitor activityextracellular region,extracellular space,Golgi apparatus,extracellular matrix,platelet alpha granule lumen,secretory granule lumen,extracellular exosome,blood microparticleX>sp|P02765|FETUA_HUMAN Alpha-2-HS-glycoprotein OS=Homo sapiens OX=9606 GN=AHSG PE=1 SV=2Q9NRA2SLC17A5 S17A5_HUMANSialinion transport,anion transport,amino acid transport,sialic acid transport,proton transport,carboxylic acid transmembrane transporttsugar:proton symporter activity,sialic acid transmembrane transporter activity,sialic acid:proton symporter activitylysosomal membrane,cytosol,plasma membrane,integral component of plasma membrane,membrane,cell junction,synaptic vesicle membraneJ>sp|Q9NRA2|S17A5_HUMAN Sialin OS=Homo sapiens OX=9606 GN=SLC17A5 PE=1 SV=2Q9P0L0VAPA VAPA_HUMAN8Vesicle-associated membrane protein-associated protein A,ER to Golgi vesicle-mediated transport,signal transduction,cell death,sphingolipid biosynthetic process,neuron projection development,positive regulation of I-kappaB kinase/NF-kappaB signaling,neutrophil degranulation,positive regulation by host of viral release from host cell,negative regulation by host of viral genome replication,positive regulation by host of viral genome replication,membrane fusion,protein localization to endoplasmic reticulum,COPII-coated vesicle budding,endoplasmic reticulum organization,protein folding in endoplasmic reticulumsignal transducer activity,protein binding,microtubule binding,protein domain specific binding,FFAT motif binding,cadherin binding,protein heterodimerization activityGolgi membrane,endoplasmic reticulum,endoplasmic reticulum membrane,plasma membrane,microtubule cytoskeleton,integral component of membrane,nuclear membrane,vesicle,azurophil granule membrane,endoplasmic reticulum exit site,bicellular tight junction,perinuclear region of cytoplasmx>sp|Q9P0L0|VAPA_HUMAN Vesicle-associated membrane protein-associated protein A OS=Homo sapiens OX=9606 GN=VAPA PE=1 SV=3Q12907LMAN2 LMAN2_HUMAN)Vesicular integral-membrane protein VIP36hretrograde vesicle-mediated transport, Golgi to ER,protein transport,positive regulation of phagocytosisfglycoprotein binding,mannose binding,carbohydrate binding,heat shock protein binding,metal ion binding Golgi membrane,extracellular space,endoplasmic reticulum membrane,endoplasmic reticulum-Golgi intermediate compartment,Golgi apparatus,integral component of plasma membrane,cell surface,endoplasmic reticulum-Golgi intermediate compartment membrane,extracellular exosomek>sp|Q12907|LMAN2_HUMAN Vesicular integral-membrane protein VIP36 OS=Homo sapiens OX=9606 GN=LMAN2 PE=1 SV=1Q96EY5MVB12A MB12A_HUMANMultivesicular body subunit 12Afprotein transport,macroautophagy,virus maturation,multivesicular body assembly,viral budding via host ESCRT complex,regulation of epidermal growth factor receptor signaling pathway,ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway,positive regulation of viral process,regulation of viral budding via host ESCRT complexBprotein binding,lipid binding,SH3 domain binding,ubiquitin bindingsESCRT I complex,nucleoplasm,Golgi apparatus,centrosome,cytosol,late endosome membrane,vesicle,extracellular exosomeb>sp|Q96EY5|MB12A_HUMAN Multivesicular body subunit 12A OS=Homo sapiens OX=9606 GN=MVB12A PE=1 SV=10P0C0S8;P20671;Q16777;Q6FI13;Q96KK5;Q99878;Q9BTM1-H2AC11;H2AC7;H2AC20;H2AC18;H2AC12;H2AC14;H2AJQH2A1_HUMAN;H2A1D_HUMAN;H2A2C_HUMAN;H2A2A_HUMAN;H2A1H_HUMAN;H2A1J_HUMAN;H2AJ_HUMANHistone H2A type 1;Histone H2A type 1-< D;Histone H2A type 2-C;Histone H2A type 2-A;Histone H2A type 1-H;Histone H2A type 1-J;Histone H2A.Jchromatin silencing,biological_process;chromatin silencing,biological_process;chromatin silencing,biological_process;chromatin silencing,biological_process;chromatin silencing,biological_process;chromatin silencing,biological_process;chromatin silencing,biological_processDNA binding,protein binding,enzyme binding,protein heterodimerization activity;molecular_function,DNA binding,protein heterodimerization activity;molecular_function,DNA binding,protein heterodimerization activity;molecular_function,DNA binding,protein heterodimerization activity;molecular_function,DNA binding,protein heterodimerization activity;molecular_function,DNA binding,protein heterodimerization activity;molecular_function,DNA binding,protein heterodimerization activitynucleosome,nuclear chromatin,nucleus,extracellular exosome;nucleosome,nuclear chromatin,nucleus,extracellular exosome;nucleosome,nuclear chromatin,nucleus,extracellular exosome;nucleosome,nuclear chromatin,nucleus,extracellular exosome;nucleosome,nuclear chromatin,extracellular exosome;nucleosome,nuclear chromatin,nucleus,extracellular exosome;nucleosome,nuclear chromatin,extracellular exosome 2;2;4;3;3;3;1Y>sp|P0C0S8|H2A1_HUMAN Histone H2A type 1 OS=Homo sapiens OX=9606 GN=H2AC11 PE=1 SV=2;>sp|P20671|H2A1D_HUMAN Histone H2A type 1-D OS=Homo sapiens OX=9606 GN=H2AC7 PE=1 SV=2;>sp|Q16777|H2A2C_HUMAN Histone H2A type 2-C OS=Homo sapiens OX=9606 GN=H2AC20 PE=1 SV=4;>sp|Q6FI13|H2A2A_HUMAN Histone H2A type 2-A OS=Homo sapiens OX=9606 GN=H2AC18 PE=1 SV=3;>sp|Q96KK5|H2A1H_HUMAN Histone H2A type 1-H OS=Homo sapiens OX=9606 GN=H2AC12 PE=1 SV=3;>sp|Q99878|H2A1J_HUMAN Histone H2A type 1-J OS=Homo sapiens OX=9606 GN=H2AC14 PE=1 SV=3;>sp|Q9BTM1|H2AJ_HUMAN Histone H2A.J OS=Homo sapiens OX=9606 GN=H2AJ PE=1 SV=1P63096GNAI1 GNAI1_HUMAN7Guanine nucleotide-binding protein G(i) subunit alpha-1wprotein folding,cell cycle,G-protein coupled receptor signaling pathway,adenylate cyclase-modulating G-protein coupled receptor signaling pathway,adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway,response to peptide hormone,regulation of cAMP-mediated signaling,negative regulation of synaptic transmission,cell division,cellular response to forskolinmagnesium ion binding,G-protein coupled receptor binding,GTPase activity,signal transducer activity,protein binding,GTP binding,GDP binding,G-protein beta/gamma-subunit complex binding,G-protein coupled serotonin receptor binding,GTPase activating protein bindingnucleus,nucleolus,cytoplasm,lysosomal membrane,centrosome,heterotrimeric G-protein complex,plasma membrane,midbody,membrane raft,extracellular exosomey>sp|P63096|GNAI1_HUMAN Guanine nucleotide-binding protein G(i) subunit alpha-1 OS=Homo sapiens OX=9606 GN=GNAI1 PE=1 SV=2Q9BXS5AP1M1 AP1M1_HUMANAP-1 complex subunit mu-1intracellular protein transport,viral process,antigen processing and presentation of exogenous peptide antigen via MHC class II,melanosome organization,endosome to melanosome transport,neutrophil degranulation,regulation of defense response to virus by virusGolgi membrane,lysosomal membrane,cytosol,plasma membrane,membrane,clathrin adaptor complex,cytoplasmic vesicle membrane,clathrin-coated endocytic vesicle membrane,trans-Golgi network membrane,specific granule membrane,extracellular exosome[>sp|Q9BXS5|AP1M1_HUMAN AP-1 complex subunit mu-1 OS=Homo sapiens OX=9606 GN=AP1M1 PE=1 SV=3P30086PEBP1 PEBP1_HUMAN*Phosphatidylethanolamine-binding protein 1:MAPK cascade,negative regulation of endopeptidase activityRNA binding,serine-type endopeptidase inhibitor activity,protein binding,ATP binding,phosphatidylethanolamine binding,enzyme binding,protein kinase bindingl>sp|P30086|PEBP1_HUMAN Phosphatidylethanolamine-binding protein 1 OS=Homo sapiens OX=9606 GN=PEBP1 PE=1 SV=3Q16832DDR2 DDR2_HUMAN&Discoidin domain-containing receptor 2ossification,endochondral bone growth,cell adhesion,signal transduction,regulation of extracellular matrix disassembly,positive regulation of fibroblast migration,peptidyl-tyrosine phosphorylation,extracellular matrix organization,collagen fibril organization,regulation of bone mineralization,biomineral tissue development,chondrocyte proliferation,collagen-activated tyrosine kinase receptor signaling pathway,positive regulation of osteoblast differentiation,positive regulation of protein kinase activity,protein autophosphorylation,positive regulation of fibroblast proliferation,positive regulation of sequence-specific DNA binding transcription factor activity,positive regulation of extracellular matrix disassemblytransmembrane receptor protein tyrosine kinase activity,protein binding,collagen binding,ATP binding,protein tyrosine kinase collagen receptor activityplasma membrane,integral component of plasma membrane,focal adhesion,actin cytoskeleton,apical plasma membrane,extracellular exosomef>sp|Q16832|DDR2_HUMAN Discoidin domain-containing receptor 2 OS=Homo sapiens OX=9606 GN=DDR2 PE=1 SV=2O00300 TNFRSF11B TR11B_HUMAN5Tumor necrosis factor receptor superfamily member 11B skeletal system development,inflammatory response,immune response,signal transduction,response to nutrient,extracellular matrix organization,response to magnesium ion,response to lipopolysaccharide,tumor necrosis factor-mediated signaling pathway,regulation of cell proliferation,negative regulation of odontogenesis of dentin-containing tooth,response to drug,regulation of apoptotic process,response to estrogen,negative regulation of bone resorption,response to arsenic-containing substance,apoptotic signaling pathwayUreceptor activity,tumor necrosis factor-activated receptor activity,cytokine activityextracellular region,proteinaceous extracellular matrix,extracellular space,plasma membrane,integral component of plasma membrane{>sp|O00300|TR11B_HUMAN Tumor necrosis factor receptor superfamily member 11B OS=Homo sapiens OX=9606 GN=TNFRSF11B PE=1 SV=3P51659HSD17B4 DHB4_HUMAN)Peroxisomal multifunctional enzyme type 2very long-chain fatty acid metabolic process,osteoblast differentiation,fatty acid beta-oxidation,bile acid biosynthetic process,androgen metabolic process,estrogen metabolic process,fatty acid beta-oxidation using acyl-CoA oxidase,alpha-linolenic acid metabolic process,very long-chain fatty-acyl-CoA metabolic process,medium-chain fatty-acyl-CoA metabolic process,Sertoli cell development3-hydroxyacyl-CoA dehydrogenase activity,receptor binding,long-chain-enoyl-CoA hydratase activity,isomerase activity,3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity,protein homodimerization activity,17-beta-hydroxysteroid dehydrogenase (NAD+) activityImitochondrion,peroxisome,peroxisomal membrane,peroxisomal matrix,membranel>sp|P51659|DHB4_HUMAN Peroxisomal multifunctional enzyme type 2 OS=Homo sapiens OX=9606 GN=HSD17B4 PE=1 SV=3P02671FGA FIBA_HUMANFibrinogen alpha chaintoll-like receptor signaling pathway,adaptive immune response,platelet degranulation,protein complex assembly,cell-matrix adhesion,blood coagulation,extracellular matrix organization,plasminogen activation,positive regulation of heterotypic cell-cell adhesion,fibrinolysis,induction of bacterial agglutination,cellular protein complex assembly,cellular protein metabolic process,innate immune response,positive regulation of vasoconstriction,positive regulation of exocytosis,positive regulation of protein secretion,protein polymerization,response to calcium ion,positive regulation of ERK1 and ERK2 cascade,platelet aggregation,blood coagulation, common pathway,blood coagulation, fibrin clot formation,positive regulation of peptide hormone secretion,positive regulation of substrate adhesion-dependent cell spreading,negative regulation of extrinsic apoptotic signaling pathway via death domain receptors,negative regulation of endothelial cell apoptotic processstructural molecule activity,protein binding,protein binding, bridging,metal ion binding,receptor binding,cell adhesion molecule bindingU>sp|P02671|FIBA_HU< MAN Fibrinogen alpha chain OS=Homo sapiens OX=9606 GN=FGA PE=1 SV=2P61020RAB5B RAB5B_HUMANRas-related protein Rab-5Bendosome organization,small GTPase mediated signal transduction,protein transport,antigen processing and presentation,regulation of endocytosis,neutrophil degranulation,plasma membrane to endosome transport,membrane organizationUGTPase activity,protein binding,GTP binding,GDP binding,GTP-dependent protein bindingintracellular,endosome,early endosome,plasma membrane,membrane,endocytic vesicle,secretory granule membrane,early endosome membrane,melanosome,intracellular membrane-bounded organelle,extracellular exosome\>sp|P61020|RAB5B_HUMAN Ras-related protein Rab-5B OS=Homo sapiens OX=9606 GN=RAB5B PE=1 SV=1P48449LSS LSS_HUMANLanosterol synthase]steroid biosynthetic process,cholesterol biosynthetic process,regulation of protein stabilitylanosterol synthase activity6endoplasmic reticulum membrane,lipid particle,membraneQ>sp|P48449|LSS_HUMAN Lanosterol synthase OS=Homo sapiens OX=9606 GN=LSS PE=1 SV=1P10321HLA-C HLAC_HUMAN5HLA class I histocompatibility antigen, C alpha chainv>sp|P10321|HLAC_HUMAN HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=3>O60814;P57053;P58876;P62807;Q5QNW6;Q93079;Q99877;Q99879;Q99880:H2BC12;H2BS1;H2BC5;H2BC4;H2BC18;H2BC9;H2BC15;H2BC14;H2BC13kH2B1K_HUMAN;H2BFS_HUMAN;H2B1D_HUMAN;H2B1C_HUMAN;H2B2F_HUMAN;H2B1H_HUMAN;H2B1N_HUMAN;H2B1M_HUMAN;H2B1L_HUMANHistone H2B type 1-K;Histone H2B type F-S;Histone H2B type 1-D;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-F;Histone H2B type 1-H;Histone H2B type 1-N;Histone H2B type 1-M;Histone H2B type 1-Linnate immune response in mucosa,nucleosome assembly,protein ubiquitination,antibacterial humoral response,defense response to Gram-positive bacterium;innate immune response in mucosa,nucleosome assembly,antibacterial humoral response,substantia nigra development,defense response to Gram-positive bacterium;nucleosome assembly,protein ubiquitination;innate immune response in mucosa,nucleosome assembly,protein ubiquitination,antibacterial humoral response,defense response to Gram-positive bacterium;nucleosome assembly;nucleosome assembly,protein ubiquitination;nucleosome assembly,protein ubiquitination;nucleosome assembly,protein ubiquitination;nucleosome assembly,protein ubiquitinationmolecular_function,DNA binding,protein heterodimerization activity;DNA binding,protein heterodimerization activity;molecular_function,DNA binding,protein heterodimerization activity;DNA binding,protein binding,protein heterodimerization activity;molecular_function,DNA binding,protein heterodimerization activity;DNA binding,protein heterodimerization activity;DNA binding,protein heterodimerization activity;DNA binding,protein heterodimerization activity;DNA binding,protein heterodimerization activity4nucleosome,extracellular space,nucleus,nucleoplasm,cytosol;nucleosome,extracellular space,nucleus,nucleoplasm,cytosol;nucleosome,nucleus,nucleoplasm,cytosol,extracellular exosome;nucleosome,extracellular space,nucleus,nucleoplasm,cytosol,extracellular exosome;nucleosome,nucleus,nucleoplasm,cytosol,extracellular exosome;nucleosome,nucleus,nucleoplasm,cytosol,extracellular exosome;nucleosome,nucleus,nucleoplasm,cytosol,extracellular exosome;nucleosome,nucleus,nucleoplasm,cytosol,extracellular exosome;nucleosome,nucleus,nucleoplasm,cytosol,extracellular exosome3;2;2;4;3;3;3;3;3>sp|O60814|H2B1K_HUMAN Histone H2B type 1-K OS=Homo sapiens OX=9606 GN=H2BC12 PE=1 SV=3;>sp|P57053|H2BFS_HUMAN Histone H2B type F-S OS=Homo sapiens OX=9606 GN=H2BS1 PE=1 SV=2;>sp|P58876|H2B1D_HUMAN Histone H2B type 1-D OS=Homo sapiens OX=9606 GN=H2BC5 PE=1 SV=2;>sp|P62807|H2B1C_HUMAN Histone H2B type 1-C/E/F/G/I OS=Homo sapiens OX=9606 GN=H2BC4 PE=1 SV=4;>sp|Q5QNW6|H2B2F_HUMAN Histone H2B type 2-F OS=Homo sapiens OX=9606 GN=H2BC18 PE=1 SV=3;>sp|Q93079|H2B1H_HUMAN Histone H2B type 1-H OS=Homo sapiens OX=9606 GN=H2BC9 PE=1 SV=3;>sp|Q99877|H2B1N_HUMAN Histone H2B type 1-N OS=Homo sapiens OX=9606 GN=H2BC15 PE=1 SV=3;>sp|Q99879|H2B1M_HUMAN Histone H2B type 1-M OS=Homo sapiens OX=9606 GN=H2BC14 PE=1 SV=3;>sp|Q99880|H2B1L_HUMAN Histone H2B type 1-L OS=Homo sapiens OX=9606 GN=H2BC13 PE=1 SV=3Q9Y639NPTN NPTN_HUMAN Neuroplastinpositive regulation of protein phosphorylation,homophilic cell adhesion via plasma membrane adhesion molecules,transmembrane receptor protein tyrosine kinase signaling pathway,positive regulation of cytosolic calcium ion concentration,visual learning,positive regulation of neuron projection development,peptidyl-tyrosine phosphorylation,positive regulation of fibroblast growth factor receptor signaling pathway,positive regulation of long-term neuronal synaptic plasticity,long-term synaptic potentiation,positive regulation of ERK1 and ERK2 cascade,positive regulation of long-term synaptic potentiation,regulation of receptor localization to synapse,positive regulation of cellular protein localization,excitatory synapse assemblytransmembrane receptor protein tyrosine kinase activity,type 1 fibroblast growth factor receptor binding,ion channel binding,cell adhesion molecule bindingqcell surface,postsynaptic density,integral component of membrane,dendrite,presynaptic membrane,inhibitory synapseL>sp|Q9Y639|NPTN_HUMAN Neuroplastin OS=Homo sapiens OX=9606 GN=NPTN PE=1 SV=2O95980RECK RECK_HUMAN:Reversion-inducing cysteine-rich protein with Kazal motifsblood vessel maturation,C-terminal protein lipidation,embryo implantation,extracellular matrix organization,negative regulation of cell migration,embryonic forelimb morphogenesis,negative regulation of metalloendopeptidase activityendopeptidase inhibitor activity,serine-type endopeptidase inhibitor activity,protein binding,metalloendopeptidase inhibitor activityLextracellular region,plasma membrane,membrane,anchored component of membranez>sp|O95980|RECK_HUMAN Reversion-inducing cysteine-rich protein with Kazal motifs OS=Homo sapiens OX=9606 GN=RECK PE=1 SV=1P23458JAK1 JAK1_HUMANTyrosine-protein kinase JAK1cMAPK cascade,protein phosphorylation,transmembrane receptor protein tyrosine kinase signaling pathway,cell migration,cell differentiation,intracellular signal transduction,peptidyl-tyrosine autophosphorylation,interleukin-2-mediated signaling pathway,regulation of cell proliferation,positive regulation of GTPase activity,innate immune response,response to antibiotic,interferon-gamma-mediated signaling pathway,regulation of interferon-gamma-mediated signaling pathway,type I interferon signaling pathway,regulation of type I interferon-mediated signaling pathway,positive regulation of sprouting angiogenesisBprotein tyrosine kinase activity,non-membrane spanning protein tyrosine kinase activity,Ras guanyl-nucleotide exchange factor activity,receptor binding,growth hormone receptor binding,protein binding,ATP binding,protein phosphatase binding,ubiquitin protein ligase binding,CCR5 chemokine receptor binding,metal ion bindingnucleus,cytoplasm,cytosol,cytoskeleton,focal adhesion,endomembrane system,extrinsic component of cytoplasmic side of plasma membrane\>sp|P23458|JAK1_HUMAN Tyrosine-protein kinase JAK1 OS=Homo sapiens OX=9606 GN=JAK1 PE=1 SV=2P54920NAPA SNAA_HUMAN$Alpha-soluble NSF attachment proteinqintracellular protein transport,ER to Golgi vesicle-mediated transport,retrograde vesicle-mediated transport, Golgi to ER,intra-Golgi vesicle-mediated transport,brain development,regulation of synaptic vesicle priming,neuron differentiation,synaptic transmission, glutamatergic,SNARE complex disassembly,apical protein localization,COPII vesicle coating,membrane fusionnSNARE binding,soluble NSF attachment protein activity,protein binding,syntaxin binding,protein complex bindingGolgi membrane,vacuolar membrane,cytosol,membrane,SNARE complex,terminal bouton,myelin sheath,synaptobrevin 2-SNAP-25-syntaxin-1a complex,extracellular exosomed>sp|P54920|SNAA_HUMAN Alpha-soluble NSF attachment protein OS=Homo sapiens OX=9606 GN=NAPA PE=1 SV=3O75396SEC22B SC22B_HUMAN"Vesicle-trafficking protein SEC22bantigen pr< ocessing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent,ER to Golgi vesicle-mediated transport,retrograde vesicle-mediated transport, Golgi to ER,protein transport,regulation of organelle organization,positive regulation of protein catabolic process,COPII vesicle coating,vesicle fusion with Golgi apparatus,vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane,exocytosis-Golgi membrane,endoplasmic reticulum membrane,endoplasmic reticulum-Golgi intermediate compartment,ER to Golgi transport vesicle membrane,integral component of membrane,transport vesicle,phagocytic vesicle membrane,SNARE complex,endoplasmic reticulum-Golgi intermediate compartment membrane,melanosomee>sp|O75396|SC22B_HUMAN Vesicle-trafficking protein SEC22b OS=Homo sapiens OX=9606 GN=SEC22B PE=1 SV=4P04439HLA-A HLAA_HUMAN5HLA class I histocompatibility antigen, A alpha chainv>sp|P04439|HLAA_HUMAN HLA class I histocompatibility antigen, A alpha chain OS=Homo sapiens OX=9606 GN=HLA-A PE=1 SV=2P13646KRT13 K1C13_HUMANKeratin, type I cytoskeletal 13cytoskeleton organization,response to radiation,keratinization,tongue morphogenesis,cornification,cellular response to retinoic acidYnucleus,cytosol,keratin filament,intermediate filament cytoskeleton,extracellular exosomea>sp|P13646|K1C13_HUMAN Keratin, type I cytoskeletal 13 OS=Homo sapiens OX=9606 GN=KRT13 PE=1 SV=4P36405ARL3 ARL3_HUMAN&ADP-ribosylation factor-like protein 3cytokinesis,kidney development,post-Golgi vesicle-mediated transport,smoothened signaling pathway,small GTPase mediated signal transduction,intraciliary transport,photoreceptor cell development,cilium morphogenesis]GTPase activity,protein binding,GTP binding,microtubule binding,GDP binding,metal ion bindingGolgi membrane,nucleus,Golgi apparatus,centrosome,spindle microtubule,cytoplasmic microtubule,cilium,midbody,photoreceptor connecting cilium,extracellular exosomef>sp|P36405|ARL3_HUMAN ADP-ribosylation factor-like protein 3 OS=Homo sapiens OX=9606 GN=ARL3 PE=1 SV=2P09972ALDOC ALDOC_HUMAN Fructose-bisphosphate aldolase Cfructose metabolic process,gluconeogenesis,fructose 1,6-bisphosphate metabolic process,epithelial cell differentiation,neutrophil degranulation,canonical glycolysisTfructose-bisphosphate aldolase activity,protein binding,cytoskeletal protein bindingextracellular region,mitochondrion,cytosol,cytoskeleton,secretory granule lumen,extracellular exosome,tertiary granule lumen,ficolin-1-rich granule lumenb>sp|P09972|ALDOC_HUMAN Fructose-bisphosphate aldolase C OS=Homo sapiens OX=9606 GN=ALDOC PE=1 SV=2P05109S100A8 S10A8_HUMANProtein S100-A8cytokine production,toll-like receptor signaling pathway,leukocyte migration involved in inflammatory response,acute inflammatory response,chronic inflammatory response,positive regulation of peptide secretion,autophagy,apoptotic process,activation of cysteine-type endopeptidase activity involved in apoptotic process,inflammatory response,response to zinc ion,astrocyte development,peptidyl-cysteine S-nitrosylation,antimicrobial humoral response,positive regulation of cell growth,neutrophil chemotaxis,sequestering of zinc ion,response to lipopolysaccharide,chemokine production,wound healing,defense response to bacterium,neutrophil degranulation,innate immune response,response to ethanol,positive regulation of inflammatory response,defense response to fungus,positive regulation of NF-kappaB transcription factor activity,regulation of cytoskeleton organization,neutrophil aggregation,positive regulation of intrinsic apoptotic signaling pathwaycalcium ion binding,protein binding,microtubule binding,zinc ion binding,Toll-like receptor 4 binding,arachidonic acid binding,RAGE receptor bindingextracellular region,extracellular space,nucleus,cytosol,cytoskeleton,plasma membrane,secretory granule lumen,intermediate filament cytoskeleton,extracellular exosomeR>sp|P05109|S10A8_HUMAN Protein S100-A8 OS=Homo sapiens OX=9606 GN=S100A8 PE=1 SV=1P11766ADH5 ADHX_HUMANAlcohol dehydrogenase class-3retinoid metabolic process,respiratory system process,ethanol oxidation,peptidyl-cysteine S-nitrosylation,response to lipopolysaccharide,positive regulation of blood pressure,formaldehyde catabolic process,response to nitrosative stress,response to redox statealcohol dehydrogenase (NAD) activity,fatty acid binding,zinc ion binding,electron carrier activity,formaldehyde dehydrogenase activity,protein homodimerization activity,S-(hydroxymethyl)glutathione dehydrogenase activity]>sp|P11766|ADHX_HUMAN Alcohol dehydrogenase class-3 OS=Homo sapiens OX=9606 GN=ADH5 PE=1 SV=4Q96S97MYADM MYADM_HUMAN)Myeloid-associated differentiation markernegative regulation of protein phosphorylation,negative regulation of gene expression,positive regulation of cell migration,negative regulation of actin filament polymerization,membrane raft organization,negative regulation of heterotypic cell-cell adhesion,establishment of endothelial barrier,protein targeting to plasma membrane,negative regulation of protein kinase C signaling,positive regulation of substrate adhesion-dependent cell spreading,regulation of cell-substrate adhesion,cell-cell junction maintenanceruffle,plasma membrane,cell-cell junction,integral component of membrane,cortical actin cytoskeleton,membrane raft,extracellular exosomek>sp|Q96S97|MYADM_HUMAN Myeloid-associated differentiation marker OS=Homo sapiens OX=9606 GN=MYADM PE=1 SV=2Q13443ADAM9 ADAM9_HUMAN=Disintegrin and metalloproteinase domain-containing protein 9\activation of MAPKK activity,membrane protein ectodomain proteolysis,cell adhesion,cell-matrix adhesion,transforming growth factor beta receptor signaling pathway,integrin-mediated signaling pathway,response to manganese ion,cell migration,keratinocyte differentiation,cell adhesion mediated by integrin,positive regulation of cell adhesion mediated by integrin,cell-cell adhesion mediated by integrin,positive regulation of macrophage fusion,response to tumor necrosis factor,response to laminar fluid shear stress,monocyte activation,response to hydrogen peroxide,positive regulation of protein secretion,positive regulation of membrane protein ectodomain proteolysis,PMA-inducible membrane protein ectodomain proteolysis,response to glucocorticoid,positive regulation of keratinocyte migration,response to calcium ion,cellular response to lipopolysaccharidemetalloendopeptidase activity,protein kinase C binding,integrin binding,protein binding,collagen binding,metallopeptidase activity,SH3 domain binding,laminin binding,metal ion bindingextracellular space,focal adhesion,cell surface,integral component of membrane,basolateral plasma membrane,intrinsic component of external side of plasma membrane,extracellular exosome>sp|Q13443|ADAM9_HUMAN Disintegrin and metalloproteinase domain-containing protein 9 OS=Homo sapiens OX=9606 GN=ADAM9 PE=1 SV=1P11279LAMP1 LAMP1_HUMAN+Lysosome-associated membrane glycoprotein 1granzyme-mediated apoptotic signaling pathway,neutrophil degranulation,positive regulation of natural killer cell degranulation,positive regulation of natural killer cell mediated cytotoxicity,viral entry into host cell,autophagic cell death,protein stabilization,establishment of protein localization to organelle,Golgi to lysosome transport,regulation of organelle transport along microtubuleVvirus receptor activity,protein binding,enzyme binding,protein domain specific bindingcytoplasm,lysosome,lysosomal membrane,late endosome,multivesicular body,cytosol,plasma membrane,integral component of plasma membrane,synaptic vesicle,external side of plasma membrane,endosome membrane,membrane,dendrite,azurophil granule membrane,sarcolemma,melanosome,neuronal cell body,cytolytic granule,autolysosome,perinuclear region of cytoplasm,phagolysosome membrane,extracellular exosome,alveolar lamellar body,ficolin-1-rich granule membranem>sp|P11279|LAMP1_HUMAN Lysosome-associated membrane glycoprotein 1 OS=Homo sapiens OX=9606 GN=LAMP1 PE=1 SV=3P60903S100A10 S10AA_HUMANProtein S100-A10< tmembrane raft assembly,membrane budding,response to drug,positive regulation of GTPase activity,positive regulation of binding,protein heterotetramerization,positive regulation of stress fiber assembly,positive regulation of focal adhesion assembly,establishment of protein localization to plasma membrane,positive regulation of substrate adhesion-dependent cell spreadinggcalcium ion binding,protein binding,protein homodimerization activity,ion channel binding,lipid binding`endoplasmic reticulum,extrinsic component of plasma membrane,extracellular exosome,membrane raftT>sp|P60903|S10AA_HUMAN Protein S100-A10 OS=Homo sapiens OX=9606 GN=S100A10 PE=1 SV=2P08962CD63 CD63_HUMAN CD63 antigenpositive regulation of receptor internalization,platelet degranulation,cell-matrix adhesion,protein transport,cell migration,cellular protein localization,endosome to melanosome transport,neutrophil degranulation,pigment granule maturation,regulation of vascular endothelial growth factor signaling pathway,regulation of rubidium ion transport,positive regulation of integrin-mediated signaling pathwaygextracellular space,lysosomal membrane,plasma membrane,integral component of plasma membrane,cell surface,endosome membrane,platelet dense granule membrane,intrinsic component of plasma membrane,late endosome membrane,endosome lumen,multivesicular body membrane,azurophil granule membrane,melanosome,extracellular exosome,multivesicular body, internal vesicleL>sp|P08962|CD63_HUMAN CD63 antigen OS=Homo sapiens OX=9606 GN=CD63 PE=1 SV=2P54709ATP1B3 AT1B3_HUMAN3Sodium/potassium-transporting ATPase subunit beta-3htransport,cellular sodium ion homeostasis,potassium ion import,establishment or maintenance of transmembrane electrochemical gradient,cellular potassium ion homeostasis,positive regulation of ATPase activity,ion transmembrane transport,sodium ion export from cell,protein stabilization,leukocyte migration,protein localization to plasma membrane,membrane repolarization,ATP hydrolysis coupled transmembrane transport,positive regulation of potassium ion transmembrane transporter activity,positive regulation of sodium ion export from cell,positive regulation of potassium ion import,regulation of cardiac conductionTATPase activator activity,sodium:potassium-exchanging ATPase activity,ATPase bindingcplasma membrane,sodium:potassium-exchanging ATPase complex,caveola,melanosome,extracellular exosomev>sp|P54709|AT1B3_HUMAN Sodium/potassium-transporting ATPase subunit beta-3 OS=Homo sapiens OX=9606 GN=ATP1B3 PE=1 SV=1P31150GDI1 GDIA_HUMAN$Rab GDP dissociation inhibitor alphaGsignal transduction,protein transport,Rab protein signal transduction,positive regulation of GTPase activity,negative regulation of axonogenesis,regulation of small GTPase mediated signal transduction,response to calcium ion,oxidation-reduction process,membrane organization,negative regulation of protein targeting to membraneGDP-dissociation inhibitor activity,Rab GDP-dissociation inhibitor activity,GTPase activator activity,protein binding,oxidoreductase activity,Rab GTPase bindingYcytoplasm,Golgi apparatus,cytosol,midbody,neuron projection,myelin sheath,protein complexd>sp|P31150|GDIA_HUMAN Rab GDP dissociation inhibitor alpha OS=Homo sapiens OX=9606 GN=GDI1 PE=1 SV=2P32119PRDX2 PRDX2_HUMANPeroxiredoxin-2%response to reactive oxygen species,response to oxidative stress,removal of superoxide radicals,cellular response to oxidative stress,hydrogen peroxide catabolic process,regulation of apoptotic process,negative regulation of apoptotic process,cell redox homeostasis,oxidation-reduction process4thioredoxin peroxidase activity,antioxidant activityQ>sp|P32119|PRDX2_HUMAN Peroxiredoxin-2 OS=Homo sapiens OX=9606 GN=PRDX2 PE=1 SV=5P17931LGALS3 LEG3_HUMAN Galectin-3omonocyte chemotaxis,mRNA processing,RNA splicing,neutrophil chemotaxis,epithelial cell differentiation,regulation of T cell proliferation,neutrophil degranulation,innate immune response,negative regulation of endocytosis,eosinophil chemotaxis,macrophage chemotaxis,negative regulation of T cell receptor signaling pathway,positive chemotaxis,regulation of T cell apoptotic process,mononuclear cell migration,positive regulation of mononuclear cell migration,positive regulation of calcium ion import,regulation of extrinsic apoptotic signaling pathway via death domain receptors,negative regulation of immunological synapse formation,negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell,negative regulation of extrinsic apoptotic signaling pathway,positive regulation of dendritic cell differentiationeRNA binding,protein binding,IgE binding,carbohydrate binding,chemoattractant activity,laminin bindingimmunological synapse,extracellular space,nucleus,spliceosomal complex,cytoplasm,mitochondrial inner membrane,plasma membrane,membrane,secretory granule membrane,extracellular exosome,ficolin-1-rich granule membrane,extracellular matrixL>sp|P17931|LEG3_HUMAN Galectin-3 OS=Homo sapiens OX=9606 GN=LGALS3 PE=1 SV=5P59998ARPC4 ARPC4_HUMAN+Actin-related protein 2/3 complex subunit 4actin filament polymerization,Arp2/3 complex-mediated actin nucleation,Fc-gamma receptor signaling pathway involved in phagocytosis,actin nucleation,ephrin receptor signaling pathway,membrane organizationvstructural constituent of cytoskeleton,protein binding,enzyme binding,protein binding, bridging,actin filament bindingDcytosol,Arp2/3 protein complex,cell projection,extracellular exosomem>sp|P59998|ARPC4_HUMAN Actin-related protein 2/3 complex subunit 4 OS=Homo sapiens OX=9606 GN=ARPC4 PE=1 SV=3P09651HNRNPA1 ROA1_HUMAN*Heterogeneous nuclear ribonucleoprotein A1`mRNA splicing, via spliceosome,mRNA processing,RNA export from nucleus,fibroblast growth factor receptor signaling pathway,gene expression,viral process,negative regulation of telomere maintenance via telomerase,positive regulation of telomere maintenance via telomerase,mRNA transport,nuclear export,nuclear import,cellular response to sodium arsenitenucleotide binding,single-stranded DNA binding,RNA binding,single-stranded RNA binding,protein binding,telomeric repeat-containing RNA binding,G-rich strand telomeric DNA bindingnucleus,nucleoplasm,spliceosomal complex,cytoplasm,membrane,intracellular ribonucleoprotein complex,extracellular exosome,catalytic step 2 spliceosomem>sp|P09651|ROA1_HUMAN Heterogeneous nuclear ribonucleoprotein A1 OS=Homo sapiens OX=9606 GN=HNRNPA1 PE=1 SV=5P30530AXL UFO_HUMAN$Tyrosine-protein kinase receptor UFOneuron migration,natural killer cell differentiation,positive regulation of cytokine-mediated signaling pathway,blood vessel remodeling,phagocytosis,inflammatory response,signal transduction,spermatogenesis,peptidyl-tyrosine phosphorylation,forebrain cell migration,platelet activation,animal organ regeneration,cellular response to extracellular stimulus,negative regulation of interferon-gamma production,negative regulation of tumor necrosis factor production,positive regulation of natural killer cell differentiation,secretion by cell,erythrocyte homeostasis,substrate adhesion-dependent cell spreading,cellular response to interferon-alpha,ovulation cycle,apoptotic cell clearance,protein kinase B signaling,negative regulation of neuron apoptotic process,innate immune response,viral entry into host cell,vascular endothelial growth factor receptor signaling pathway,cell maturation,positive regulation of pinocytosis,negative regulation of lymphocyte activation,positive regulation of protein kinase B signaling,vagina development,cellular response to hydrogen peroxide,cellular response to lipopolysaccharide,dendritic cell differentiation,neutrophil clearance,negative regulation of dendritic cell apoptotic process virus receptor activity,phosphatidylserine binding,protein tyrosine kinase activity,transmembrane receptor protein tyrosine kinase activity,protein binding,ATP binding,myosin heavy chain binding,phosphatidylinositol 3-kinase binding,protein heterodimerization activityextracellular space,intracellu< lar,plasma membrane,integral component of plasma membrane,cell surface,host cell surface,extracellular exosomeb>sp|P30530|UFO_HUMAN Tyrosine-protein kinase receptor UFO OS=Homo sapiens OX=9606 GN=AXL PE=1 SV=4P49721PSMB2 PSB2_HUMANProteasome subunit beta type-2MAPK cascade,protein polyubiquitination,stimulatory C-type lectin receptor signaling pathway,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent,regulation of cellular amino acid metabolic process,response to organonitrogen compound,negative regulation of G2/M transition of mitotic cell cycle,response to organic cyclic compound,viral process,protein deubiquitination,anaphase-promoting complex-dependent catabolic process,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process,tumor necrosis factor-mediated signaling pathway,NIK/NF-kappaB signaling,Fc-epsilon receptor signaling pathway,proteasome-mediated ubiquitin-dependent protein catabolic process,regulation of mRNA stability,T cell receptor signaling pathway,negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition,transmembrane transport,Wnt signaling pathway, planar cell polarity pathway,regulation of transcription from RNA polymerase II promoter in response to hypoxia,negative regulation of canonical Wnt signaling pathway,positive regulation of canonical Wnt signaling pathwayeproteasome complex,nucleus,nucleoplasm,cytosol,proteasome core complex,membrane,extracellular exosome_>sp|P49721|PSB2_HUMAN Proteasome subunit beta type-2 OS=Homo sapiens OX=9606 GN=PSMB2 PE=1 SV=1Q9BZG1RAB34 RAB34_HUMANRas-related protein Rab-34small GTPase mediated signal transduction,antigen processing and presentation,lysosome localization,Golgi to plasma membrane protein transport,protein localization to plasma membrane,phagosome maturation,phagosome-lysosome fusion,macropinocytosisLprotein binding,GTP binding,Ral GTPase binding,GTP-dependent protein bindingGolgi apparatus,Golgi stack,phagocytic vesicle membrane,vesicle,Golgi cisterna,phagocytic vesicle,perinuclear region of cytoplasm,extracellular exosome,ruffle membrane\>sp|Q9BZG1|RAB34_HUMAN Ras-related protein Rab-34 OS=Homo sapiens OX=9606 GN=RAB34 PE=1 SV=1P21281ATP6V1B2 VATB2_HUMAN-V-type proton ATPase subunit B, brain isoforminsulin receptor signaling pathway,ATP hydrolysis coupled proton transport,proton transport,regulation of macroautophagy,transferrin transport,ion transmembrane transport,ATP metabolic process,phagosome acidificationprotein binding,ATP binding,hydrogen ion transmembrane transporter activity,proton-transporting ATPase activity, rotational mechanismruffle,lysosomal membrane,cytosol,plasma membrane,microvillus,endomembrane system,integral component of membrane,proton-transporting V-type ATPase, V1 domain,melanosome,myelin sheath,intracellular membrane-bounded organelle,extracellular exosomer>sp|P21281|VATB2_HUMAN V-type proton ATPase subunit B, brain isoform OS=Homo sapiens OX=9606 GN=ATP6V1B2 PE=1 SV=3P05089ARG1 ARGI1_HUMAN Arginase-1uurea cycle,liver development,positive regulation of endothelial cell proliferation,arginine catabolic process,aging,response to herbicide,response to manganese ion,response to zinc ion,response to selenium ion,regulation of L-arginine import,response to amine,arginine catabolic process to ornithine,lung development,collagen biosynthetic process,response to vitamin A,response to vitamin E,response to drug,response to amino acid,neutrophil degranulation,response to cadmium ion,response to axon injury,response to methylmercury,mammary gland involution,maternal process involved in female pregnancy,protein homotrimerization,cellular response to hydrogen peroxide,cellular response to lipopolysaccharide,cellular response to interleukin-4,cellular response to glucagon stimulus,cellular response to dexamethasone stimulus,cellular response to transforming growth factor beta stimulus'arginase activity,manganese ion bindingextracellular region,extracellular space,nucleus,cytoplasm,mitochondrial outer membrane,cytosol,azurophil granule lumen,specific granule lumen,neuron projection,neuronal cell body,extracellular exosomeK>sp|P05089|ARGI1_HUMAN Arginase-1 OS=Homo sapiens OX=9606 GN=ARG1 PE=1 SV=2Q5ZPR3CD276 CD276_HUMAN CD276 antigenimmune response,cell proliferation,positive regulation of T cell proliferation,T cell activation,positive regulation of interferon-gamma biosynthetic process,regulation of immune responseUexternal side of plasma membrane,integral component of membrane,extracellular exosomeO>sp|Q5ZPR3|CD276_HUMAN CD276 antigen OS=Homo sapiens OX=9606 GN=CD276 PE=1 SV=1P13667PDIA4 PDIA4_HUMANProtein disulfide-isomerase A4protein folding,protein secretion,response to endoplasmic reticulum stress,cell redox homeostasis,chaperone-mediated protein folding@RNA binding,protein disulfide isomerase activity,protein bindingIendoplasmic reticulum,endoplasmic reticulum lumen,cell surface,melanosome`>sp|P13667|PDIA4_HUMAN Protein disulfide-isomerase A4 OS=Homo sapiens OX=9606 GN=PDIA4 PE=1 SV=2P23381WARS1 SYWC_HUMAN$Tryptophan--tRNA ligase, cytoplasmicangiogenesis,translation,tRNA aminoacylation for protein translation,tryptophanyl-tRNA aminoacylation,negative regulation of cell proliferation,regulation of angiogenesis;tryptophan-tRNA ligase activity,protein binding,ATP bindinge>sp|P23381|SYWC_HUMAN Tryptophan--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=WARS1 PE=1 SV=2O43491EPB41L2 E41L2_HUMANBand 4.1-like protein 2Jcortical actin cytoskeleton organization,actomyosin structure organizationWactin binding,structural constituent of cytoskeleton,spectrin binding,PH domain bindingnucleus,nucleoplasm,cytosol,plasma membrane,focal adhesion,spectrin,extrinsic component of membrane,cell junction,extracellular exosome,COP9 signalosome[>sp|O43491|E41L2_HUMAN Band 4.1-like protein 2 OS=Homo sapiens OX=9606 GN=EPB41L2 PE=1 SV=1P20339RAB5A RAB5A_HUMANRas-related protein Rab-5Aphosphatidylinositol biosynthetic process,endocytosis,phagocytosis,small GTPase mediated signal transduction,blood coagulation,protein transport,regulation of endocytosis,synaptic vesicle recycling,viral RNA genome replication,early endosome to late endosome transport,positive regulation of exocytosis,regulation of endosome size,regulation of filopodium assembly,membrane organization,receptor internalization involved in canonical Wnt signaling pathway,regulation of synaptic vesicle exocytosis,regulation of autophagosome assemblyruffle,cytoplasm,endosome,early endosome,cytosol,plasma membrane,synaptic vesicle,endosome membrane,actin cytoskeleton,endocytic vesicle,axon,dendrite,clathrin-coated vesicle membrane,phagocytic vesicle membrane,early endosome membrane,somatodendritic compartment,melanosome,neuronal cell body,terminal bouton,axon terminus,membrane raft,extracellular exosome,cytoplasmic side of early endosome membrane\>sp|P20339|RAB5A_HUMAN Ras-related protein Rab-5A OS=Homo sapiens OX=9606 GN=RAB5A PE=1 SV=2P62258YWHAE 1433E_HUMAN14-3-3 protein epsilonG2/M transition of mitotic cell cycle,MAPK cascade,neuron migration,regulation of heart rate by hormone,protein targeting,viral process,substantia nigra development,hippocampus development,cerebral cortex development,cellular response to heat,hippo signaling,intracellular signal transduction,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process,positive regulation of GTPase activity,positive regulation of protein export from nucleus,regulation of membrane repolarization,membrane organization,membrane repolarization during cardiac muscle cell action potential,regulation of heart rate by cardiac conduction,ciliary basal body docking,regulation of cellular response to heat,positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway,regulation of potassium ion transmembrane transporter activity,negative r< egulation of peptidyl-serine dephosphorylationvRNA binding,protein binding,potassium channel regulator activity,Rab guanyl-nucleotide exchange factor activity,enzyme binding,protein domain specific binding,MHC class II protein complex binding,ubiquitin protein ligase binding,histone deacetylase binding,ion channel binding,cadherin binding,protein heterodimerization activity,phosphoserine binding,phosphoprotein bindingnucleus,cytoplasm,mitochondrion,cytosol,kinesin complex,focal adhesion,membrane,axon,cytoplasmic vesicle membrane,melanosome,extracellular exosomeX>sp|P62258|1433E_HUMAN 14-3-3 protein epsilon OS=Homo sapiens OX=9606 GN=YWHAE PE=1 SV=1P42892ECE1 ECE1_HUMANEndothelin-converting enzyme 1positive regulation of receptor recycling,regulation of systemic arterial blood pressure by endothelin,heart development,substance P catabolic process,bradykinin catabolic process,calcitonin catabolic process,protein processing,peptide hormone processing,regulation of vasoconstriction,endothelin maturation,hormone catabolic process,embryonic digit morphogenesis,ear development,pharyngeal system developmentendopeptidase activity,metalloendopeptidase activity,protein binding,zinc ion binding,peptide hormone binding,protein homodimerization activitylysosomal membrane,endosome,plasma membrane,external side of plasma membrane,membrane,integral component of membrane,intrinsic component of endosome membrane,vesicle,Weibel-Palade body,perinuclear region of cytoplasm,extracellular exosome^>sp|P42892|ECE1_HUMAN Endothelin-converting enzyme 1 OS=Homo sapiens OX=9606 GN=ECE1 PE=1 SV=2P61019RAB2A RAB2A_HUMANRas-related protein Rab-2AuGolgi organization,small GTPase mediated signal transduction,protein transport,ER to Golgi vesicle-mediated transportGolgi membrane,nucleus,lysosomal membrane,endoplasmic reticulum membrane,Golgi apparatus,cytosol,endoplasmic reticulum-Golgi intermediate compartment membrane,melanosome,extracellular exosome\>sp|P61019|RAB2A_HUMAN Ras-related protein Rab-2A OS=Homo sapiens OX=9606 GN=RAB2A PE=1 SV=1P01111NRAS RASN_HUMAN GTPase NRas<MAPK cascade,stimulatory C-type lectin receptor signaling pathway,epidermal growth factor receptor signaling pathway,Ras protein signal transduction,axon guidance,Fc-epsilon receptor signaling pathway,ERBB2 signaling pathway,neutrophil degranulation,leukocyte migration,establishment of protein localization to Golgi#GTP binding,protein complex bindinggGolgi membrane,Golgi apparatus,plasma membrane,membrane,extracellular exosome,tertiary granule membraneK>sp|P01111|RASN_HUMAN GTPase NRas OS=Homo sapiens OX=9606 GN=NRAS PE=1 SV=1O76009KRT33A KT33A_HUMANKeratin, type I cuticular Ha3-I1extracellular space,cytosol,intermediate filamentb>sp|O76009|KT33A_HUMAN Keratin, type I cuticular Ha3-I OS=Homo sapiens OX=9606 GN=KRT33A PE=2 SV=2Q9NSB2KRT84 KRT84_HUMANKeratin, type II cuticular Hb4hair follicle development,cytoskeleton organization,keratinization,nail development,regulation of keratinocyte differentiation,cornificationJstructural constituent of cytoskeleton,structural constituent of epidermis`>sp|Q9NSB2|KRT84_HUMAN Keratin, type II cuticular Hb4 OS=Homo sapiens OX=9606 GN=KRT84 PE=2 SV=2Q96AC1FERMT2 FERM2_HUMANFermitin family homolog 22cell-matrix adhesion,transforming growth factor beta receptor signaling pathway,integrin-mediated signaling pathway,regulation of cell shape,Wnt signaling pathway,integrin activation,cell junction assembly,substrate adhesion-dependent cell spreading,focal adhesion assembly,protein localization to membrane@protein binding,phosphatidylinositol-3,4,5-trisphosphate bindingstress fiber,nucleus,nucleoplasm,cytoplasm,cytosol,focal adhesion,cell cortex,cell surface,extrinsic component of cytoplasmic side of plasma membrane,lamellipodium membrane,I band,filamentous actin\>sp|Q96AC1|FERM2_HUMAN Fermitin family homolog 2 OS=Homo sapiens OX=9606 GN=FERMT2 PE=1 SV=1P49720PSMB3 PSB3_HUMANProteasome subunit beta type-3proteasome complex,nucleus,nucleoplasm,cytosol,proteasome core complex,proteasome core complex, beta-subunit complex,extracellular exosome_>sp|P49720|PSB3_HUMAN Proteasome subunit beta type-3 OS=Homo sapiens OX=9606 GN=PSMB3 PE=1 SV=2O75874IDH1 IDHC_HUMAN+Isocitrate dehydrogenase [NADP] cytoplasmic`glyoxylate cycle,tricarboxylic acid cycle,isocitrate metabolic process,2-oxoglutarate metabolic process,NADPH regeneration,glutathione metabolic process,response to oxidative stress,female gonad development,neutrophil degranulation,response to steroid hormone,regulation of phospholipid catabolic process,regulation of phospholipid biosynthetic processmagnesium ion binding,isocitrate dehydrogenase (NADP+) activity,receptor binding,protein homodimerization activity,cadherin binding,NADP binding,NAD binding,(R)-2-hydroxyglutarate dehydrogenase activityextracellular region,cytoplasm,mitochondrion,peroxisome,peroxisomal matrix,cytosol,secretory granule lumen,extracellular exosome,tertiary granule lumen,ficolin-1-rich granule lumenk>sp|O75874|IDHC_HUMAN Isocitrate dehydrogenase [NADP] cytoplasmic OS=Homo sapiens OX=9606 GN=IDH1 PE=1 SV=2P31946YWHAB 1433B_HUMAN14-3-3 protein beta/alphaMAPK cascade,protein targeting,viral process,negative regulation of protein dephosphorylation,hippo signaling,positive regulation of catalytic activity,regulation of mRNA stability,negative regulation of G-protein coupled receptor protein signaling pathway,negative regulation of transcription, DNA-templated,cytoplasmic sequestering of protein,protein heterooligomerization,membrane organization,positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwaytranscription corepressor activity,protein binding,protein C-terminus binding,enzyme binding,protein domain specific binding,protein complex binding,histone deacetylase binding,cadherin binding,phosphoserine binding,phosphoprotein bindingnucleus,cytoplasm,mitochondrion,cytosol,focal adhesion,membrane,transcriptional repressor complex,cytoplasmic vesicle membrane,melanosome,protein complex,perinuclear region of cytoplasm,extracellular exosome[>sp|P31946|1433B_HUMAN 14-3-3 protein beta/alpha OS=Homo sapiens OX=9606 GN=YWHAB PE=1 SV=3P08754GNAI3 GNAI3_HUMAN7Guanine nucleotide-binding protein G(i) subunit alpha-3protein folding,transport,vesicle fusion,cell cycle,adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway,negative regulation of adenylate cyclase activity,dopamine receptor signaling pathway,GTP metabolic process,cell division#G-protein coupled receptor binding,GTPase activity,signal transducer activity,protein binding,GTP binding,GDP binding,protein domain specific binding,G-protein beta/gamma-subunit complex binding,G-protein coupled serotonin receptor binding,GTPase activating protein binding,metal ion bindingnucleus,nucleolus,cytoplasm,lysosomal membrane,Golgi apparatus,centrosome,heterotrimeric G-protein complex,plasma membrane,membrane,midbody,zymogen granule,membrane raft,extracellular exosomey>sp|P08754|GNAI3_HUMAN Guanine nucleotide-binding protein G(i) subunit alpha-3 OS=Homo sapiens OX=9606 GN=GNAI3 PE=1 SV=3O60488ACSL4 ACSL4_HUMAN#Long-chain-fatty-acid--CoA ligase 4long-chain fatty acid metabolic process,lipid metabolic process,triglyceride metabolic process,response to nutrient,fatty acid transport,long-chain fatty-acyl-CoA biosynthetic process,embryonic process involved in female pregnancy,dendritic spine development,response to interleukin-15long-chain fatty acid-CoA ligase activity,ATP binding,very long-chain fatty acid-CoA ligase activity,arachidonate-CoA ligase activity,decanoate--CoA ligase activitycytoplasm,mitochondrial outer membrane,peroxisomal membrane,endoplasmic reticulum membrane,lipid particle,membrane,integral component of membrane,neuronal cell body,ER-mitochondrion membrane contact site,extracellular exosomee>sp|O60488|ACSL4_HUMAN Long-chain-fatty-acid--CoA ligase 4 OS=Homo sapiens OX=9606 GN=ACSL4 PE=1 SV=2Q9BSJ8ESYT1 ESYT1_HUMANExtended synaptotagmin-1< 3glycosphingolipid metabolic process,lipid transport/protein binding,lipid binding,metal ion bindingendoplasmic reticulum,endoplasmic reticulum membrane,plasma membrane,membrane,integral component of endoplasmic reticulum membrane,intracellular membrane-bounded organelle,organelle membrane contact siteZ>sp|Q9BSJ8|ESYT1_HUMAN Extended synaptotagmin-1 OS=Homo sapiens OX=9606 GN=ESYT1 PE=1 SV=1Q13162PRDX4 PRDX4_HUMANPeroxiredoxin-4tI-kappaB phosphorylation,spermatogenesis,male gonad development,4-hydroxyproline metabolic process,protein maturation by protein folding,extracellular matrix organization,neutrophil degranulation,cell redox homeostasis,oxidation-reduction process,reactive oxygen species metabolic process,cellular oxidant detoxification,negative regulation of male germ cell proliferationQprotein binding,thioredoxin peroxidase activity,protein homodimerization activityextracellular region,extracellular space,nucleus,mitochondrion,smooth endoplasmic reticulum,cytosol,secretory granule lumen,extracellular exosome,ficolin-1-rich granule lumenQ>sp|Q13162|PRDX4_HUMAN Peroxiredoxin-4 OS=Homo sapiens OX=9606 GN=PRDX4 PE=1 SV=1P25787PSMA2 PSA2_HUMANProteasome subunit alpha type-2MAPK cascade,protein polyubiquitination,stimulatory C-type lectin receptor signaling pathway,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent,regulation of cellular amino acid metabolic process,response to virus,negative regulation of G2/M transition of mitotic cell cycle,protein deubiquitination,anaphase-promoting complex-dependent catabolic process,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process,tumor necrosis factor-mediated signaling pathway,NIK/NF-kappaB signaling,Fc-epsilon receptor signaling pathway,proteasome-mediated ubiquitin-dependent protein catabolic process,neutrophil degranulation,regulation of mRNA stability,T cell receptor signaling pathway,negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition,transmembrane transport,Wnt signaling pathway, planar cell polarity pathway,regulation of transcription from RNA polymerase II promoter in response to hypoxia,negative regulation of canonical Wnt signaling pathway,positive regulation of canonical Wnt signaling pathwayproteasome complex,cytoplasmic mRNA processing body,extracellular region,nucleus,nucleoplasm,cytosol,proteasome core complex,proteasome core complex, alpha-subunit complex,secretory granule lumen,extracellular exosome,ficolin-1-rich granule lumen`>sp|P25787|PSA2_HUMAN Proteasome subunit alpha type-2 OS=Homo sapiens OX=9606 GN=PSMA2 PE=1 SV=2P23284PPIB PPIB_HUMAN%Peptidyl-prolyl cis-trans isomerase B?protein peptidyl-prolyl isomerization,positive regulation of multicellular organism growth,positive regulation by host of viral process,positive regulation by host of viral genome replication,protein stabilization,bone development,chaperone-mediated protein folding,regulation of post-translational protein modificationRNA binding,peptidyl-prolyl cis-trans isomerase activity,protein binding,protein complex binding,unfolded protein binding,RNA polymerase binding,collagen bindingnucleus,endoplasmic reticulum,endoplasmic reticulum lumen,smooth endoplasmic reticulum,focal adhesion,membrane,macromolecular complex,endoplasmic reticulum chaperone complex,melanosome,perinuclear region of cytoplasm,extracellular exosomee>sp|P23284|PPIB_HUMAN Peptidyl-prolyl cis-trans isomerase B OS=Homo sapiens OX=9606 GN=PPIB PE=1 SV=2P80723BASP1 BASP1_HUMANBrain acid soluble protein 1~thorax and anterior abdomen determination,gonad development,substantia nigra development,negative regulation of transcription, DNA-templated,mesenchymal to epithelial transition,positive regulation of heart growth,diaphragm development,metanephric mesenchyme development,glomerular visceral epithelial cell differentiation,positive regulation of metanephric ureteric bud development~transcription corepressor activity,protein binding,protein domain specific binding,transcription regulatory region DNA bindingnucleus,cytoplasm,cytoskeleton,plasma membrane,nuclear speck,cell junction,growth cone,vesicle,extracellular exosome,COP9 signalosome^>sp|P80723|BASP1_HUMAN Brain acid soluble protein 1 OS=Homo sapiens OX=9606 GN=BASP1 PE=1 SV=2Q04695KRT17 K1C17_HUMANKeratin, type I cytoskeletal 17signal transduction,epidermis development,positive regulation of cell growth,hair follicle morphogenesis,keratinization,intermediate filament organization,positive regulation of translation,positive regulation of hair follicle development,cornificationrstructural constituent of cytoskeleton,protein binding,MHC class II receptor activity,MHC class II protein bindingecytosol,intermediate filament,intermediate filament cytoskeleton,extracellular exosome,cell peripherya>sp|Q04695|K1C17_HUMAN Keratin, type I cytoskeletal 17 OS=Homo sapiens OX=9606 GN=KRT17 PE=1 SV=2P09104ENO2 ENOG_HUMAN Gamma-enolase$gluconeogenesis,canonical glycolysisHmagnesium ion binding,phosphopyruvate hydratase activity,protein bindingphosphopyruvate hydratase complex,photoreceptor inner segment,extracellular space,cytosol,plasma membrane,perikaryon,myelin sheath,extracellular exosomeM>sp|P09104|ENOG_HUMAN Gamma-enolase OS=Homo sapiens OX=9606 GN=ENO2 PE=1 SV=3P18084ITGB5 ITB5_HUMANIntegrin beta-5wantigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent,muscle contraction,cell-matrix adhesion,transforming growth factor beta receptor signaling pathway,integrin-mediated signaling pathway,extracellular matrix organization,endodermal cell differentiation,stress fiber assembly,viral entry into host cell,epithelial cell-cell adhesion'virus receptor activity,protein bindingplasma membrane,focal adhesion,cell surface,integrin alphav-beta5 complex,receptor complex,phagocytic vesicle,extracellular exosomeP>sp|P18084|ITB5_HUMAN Integrin beta-5 OS=Homo sapiens OX=9606 GN=ITGB5 PE=1 SV=1Q9UHG3PCYOX1 PCYOX_HUMANPrenylcysteine oxidase 1prenylated protein catabolic process,prenylcysteine catabolic process,prenylcysteine metabolic process,oxidation-reduction process,Requires Ontology,chloride transmembrane transportEprenylcysteine oxidase activity,chloride-transporting ATPase activityflysosome,vacuolar membrane,plasma membrane,very-low-density lipoprotein particle,extracellular exosome[>sp|Q9UHG3|PCYOX_HUMAN Prenylcysteine oxidase 1 OS=Homo sapiens OX=9606 GN=PCYOX1 PE=1 SV=3Q15293RCN1 RCN1_HUMANReticulocalbin-1:in utero embryonic development,camera-type eye development1endoplasmic reticulum,endoplasmic reticulum lumenP>sp|Q15293|RCN1_HUMAN Reticulocalbin-1 OS=Homo sapiens OX=9606 GN=RCN1 PE=1 SV=1P25311AZGP1 ZA2G_HUMANZinc-alpha-2-glycoproteindetection of chemical stimulus involved in sensory perception of bitter taste,retina homeostasis,cell adhesion,negative regulation of cell proliferation,antigen processing and presentation,transmembrane transport,protein transmembrane transport,RNA phosphodiester bond hydrolysisuglycoprotein binding,antigen binding,ribonuclease activity,protein binding,protein transmembrane transporter activityVextracellular region,extracellular space,nucleus,plasma membrane,extracellular exosomeZ>sp|P25311|ZA2G_HUMAN Zinc-alpha-2-glycoprotein OS=Homo sapiens OX=9606 GN=AZGP1 PE=1 SV=2P02794FTH1 FRIH_HUMANFerritin heavy chaincellular iron ion homeostasis,intracellular sequestering of iron ion,immune response,negative regulation of cell proliferation,neutrophil degranulation,negative regulation of fibroblast proliferation,oxidation-reduction process,iron ion importIferroxidase activity,iron ion binding,protein binding,ferric iron bindingextracellular region,nucleus,mitochondrion,cytosol,intracellular ferritin complex,autolysosome,extracellular exosome,tertiary granule lumen,ficolin-1-rich granule lumenT>sp|P02794|FRIH_HUMAN Ferritin heavy chain OS=Homo sap< iens OX=9606 GN=FTH1 PE=1 SV=2P62937PPIA PPIA_HUMAN%Peptidyl-prolyl cis-trans isomerase Aprotein peptidyl-prolyl isomerization,RNA-dependent DNA biosynthetic process,protein folding,viral life cycle,uncoating of virus,fusion of virus membrane with host plasma membrane,virion assembly,viral release from host cell,entry into host cell,lipid particle organization,neutrophil degranulation,regulation of viral genome replication,positive regulation of viral genome replication,positive regulation of protein secretion,leukocyte migration,establishment of integrated proviral latencypRNA binding,peptidyl-prolyl cis-trans isomerase activity,protein binding,virion binding,unfolded protein bindingextracellular region,extracellular space,nucleus,cytosol,focal adhesion,membrane,secretory granule lumen,extracellular exosome,ficolin-1-rich granule lumene>sp|P62937|PPIA_HUMAN Peptidyl-prolyl cis-trans isomerase A OS=Homo sapiens OX=9606 GN=PPIA PE=1 SV=2Q8N1N4KRT78 K2C78_HUMAN Keratin, type II cytoskeletal 78b>sp|Q8N1N4|K2C78_HUMAN Keratin, type II cytoskeletal 78 OS=Homo sapiens OX=9606 GN=KRT78 PE=1 SV=2P09382LGALS1 LEG1_HUMAN Galectin-1^plasma cell differentiation,apoptotic process,signal transduction,negative regulation of cell-substrate adhesion,negative regulation of neuron projection development,T cell costimulation,positive regulation of erythrocyte aggregation,response to isolation stress,response to drug,regulation of apoptotic process,positive regulation of I-kappaB kinase/NF-kappaB signaling,myoblast differentiation,positive regulation of viral entry into host cell,response to axon injury,cellular response to glucose stimulus,cellular response to organic cyclic compound,positive regulation of dendritic cell differentiationglycoprotein binding,RNA binding,signal transducer activity,protein binding,lactose binding,protein homodimerization activity,laminin bindingproteinaceous extracellular matrix,extracellular space,intracellular,nucleus,cytoplasm,cytosol,cell surface,extracellular matrix,extracellular exosomeL>sp|P09382|LEG1_HUMAN Galectin-1 OS=Homo sapiens OX=9606 GN=LGALS1 PE=1 SV=2O43795MYO1B MYO1B_HUMANUnconventional myosin-Ib~post-Golgi vesicle-mediated transport,actin filament organization,actin filament-based movement,actin filament bundle assemblymicrofilament motor activity,calmodulin binding,ATP binding,phosphatidylinositol-4,5-bisphosphate binding,phosphatidylinositol-3,4,5-trisphosphate binding,actin-dependent ATPase activity,cadherin binding,actin filament bindingcytoplasm,early endosome,actin filament,plasma membrane,brush border,endosome membrane,myosin complex,filopodium,apical part of cell,perinuclear region of cytoplasm,extracellular exosome,cell periphery,trans-Golgi network membraneZ>sp|O43795|MYO1B_HUMAN Unconventional myosin-Ib OS=Homo sapiens OX=9606 GN=MYO1B PE=1 SV=3P25788PSMA3 PSA3_HUMANProteasome subunit alpha type-3MAPK cascade,protein polyubiquitination,stimulatory C-type lectin receptor signaling pathway,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent,regulation of cellular amino acid metabolic process,negative regulation of G2/M transition of mitotic cell cycle,viral process,protein deubiquitination,anaphase-promoting complex-dependent catabolic process,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process,tumor necrosis factor-mediated signaling pathway,NIK/NF-kappaB signaling,Fc-epsilon receptor signaling pathway,proteasome-mediated ubiquitin-dependent protein catabolic process,regulation of mRNA stability,T cell receptor signaling pathway,negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition,regulation of endopeptidase activity,transmembrane transport,Wnt signaling pathway, planar cell polarity pathway,regulation of transcription from RNA polymerase II promoter in response to hypoxia,negative regulation of canonical Wnt signaling pathway,positive regulation of canonical Wnt signaling pathwayproteasome complex,nucleus,nucleoplasm,cytoplasm,cytosol,proteasome core complex,proteasome core complex, alpha-subunit complex,synapse,extracellular exosome`>sp|P25788|PSA3_HUMAN Proteasome subunit alpha type-3 OS=Homo sapiens OX=9606 GN=PSMA3 PE=1 SV=2P06744GPI G6PI_HUMANGlucose-6-phosphate isomeraseangiogenesis,in utero embryonic development,mesoderm formation,carbohydrate metabolic process,gluconeogenesis,humoral immune response,hemostasis,learning or memory,methylglyoxal biosynthetic process,response to estradiol,response to progesterone,response to testosterone,erythrocyte homeostasis,response to immobilization stress,response to muscle stretch,glucose homeostasis,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process,response to morphine,neutrophil degranulation,negative regulation of neuron apoptotic process,aldehyde catabolic process,response to cadmium ion,glucose 6-phosphate metabolic process,canonical glycolysisglucose-6-phosphate isomerase activity,cytokine activity,growth factor activity,intramolecular transferase activity,ubiquitin protein ligase binding,monosaccharide bindingextracellular region,extracellular space,nucleoplasm,cytosol,plasma membrane,membrane,secretory granule lumen,neuron projection,myelin sheath,ciliary membrane,extracellular exosome,ficolin-1-rich granule lumen\>sp|P06744|G6PI_HUMAN Glucose-6-phosphate isomerase OS=Homo sapiens OX=9606 GN=GPI PE=1 SV=4Q9UBG0MRC2 MRC2_HUMANC-type mannose receptor 2Uosteoblast differentiation,endocytosis,signal transduction,collagen catabolic process_transmembrane signaling receptor activity,protein binding,collagen binding,carbohydrate binding=integral component of plasma membrane,focal adhesion,membraneY>sp|Q9UBG0|MRC2_HUMAN C-type mannose receptor 2 OS=Homo sapiens OX=9606 GN=MRC2 PE=1 SV=2P33527ABCC1 MRP1_HUMAN)Multidrug resistance-associated protein 1leukotriene metabolic process,transport,drug transmembrane transport,cobalamin metabolic process,cobalamin transport,glutathione transmembrane transport,vitamin transmembrane transport,response to drug,xenobiotic transport,transmembrane transport,Requires OntologyYtransporter activity,ATP binding,xenobiotic-transporting ATPase activity,cobalamin-transporting ATPase activity,glutathione S-conjugate-exporting ATPase activity,ATPase activity,glutathione transmembrane transporter activity,ATPase activity, coupled to transmembrane movement of substances,ATPase-coupled anion transmembrane transporter activitypplasma membrane,integral component of plasma membrane,membrane,basolateral plasma membrane,extracellular exosomej>sp|P33527|MRP1_HUMAN Multidrug resistance-associated protein 1 OS=Homo sapiens OX=9606 GN=ABCC1 PE=1 SV=3P11117ACP2 PPAL_HUMANLysosomal acid phosphataseCskeletal system development,lysosome organization,dephosphorylationacid phosphatase activityilysosome,lysosomal membrane,membrane,integral component of membrane,lysosomal lumen,extracellular exosomeZ>sp|P11117|PPAL_HUMAN Lysosomal acid phosphatase OS=Homo sapiens OX=9606 GN=ACP2 PE=1 SV=3Q15907RAB11B RB11B_HUMANRas-related protein Rab-11Breceptor recycling,small GTPase mediated signal transduction,melanosome transport,transferrin transport,insulin secretion involved in cellular response to glucose stimulus,regulation of anion transport,constitutive secretory pathway,regulated exocytosis,membrane organization,cellular response to acidic pH,establishment of protein localization to membrane,retrograde transport, endosome to plasma membrane,regulation of protein localization to cell surface,regulation of endocytic recyclingYGTPase activity,protein binding,GTP binding,GDP binding,myosin V binding,cadherin bindingmitochondrion,cytosol,synaptic vesicle,cell junction,phagocytic vesicle membrane,phagocytic vesicle,recycling endosome,recycling endosome membrane,extracellular exosome,anchored component of synaptic vesicle membrane^>sp|Q15907|RB11B_HUMAN < Ras-related protein Rab-11B OS=Homo sapiens OX=9606 GN=RAB11B PE=1 SV=4P51884LUM LUM_HUMANLumicanvisual perception,response to organic cyclic compound,keratan sulfate biosynthetic process,extracellular matrix organization,collagen fibril organization,positive regulation of transforming growth factor beta1 production,keratan sulfate catabolic process,positive regulation of transcription from RNA polymerase II promoter,cartilage development,response to growth factor,axonogenesisLextracellular matrix structural constituent,protein binding,collagen bindingextracellular region,proteinaceous extracellular matrix,fibrillar collagen trimer,extracellular space,Golgi lumen,lysosomal lumen,extracellular exosome,extracellular matrixE>sp|P51884|LUM_HUMAN Lumican OS=Homo sapiens OX=9606 GN=LUM PE=1 SV=2Q14699RFTN1 RFTN1_HUMANRaftlinDmembrane raft assembly,T cell antigen processing and presentation,protein transport into membrane raft,interleukin-17 production,dsRNA transport,toll-like receptor 3 signaling pathway,growth,response to exogenous dsRNA,T cell receptor signaling pathway,B cell receptor signaling pathway,protein localization to membrane raftdouble-stranded RNA bindingVcytoplasm,endosome,plasma membrane,protein complex,membrane raft,extracellular exosomeI>sp|Q14699|RFTN1_HUMAN Raftlin OS=Homo sapiens OX=9606 GN=RFTN1 PE=1 SV=4P37802TAGLN2 TAGL2_HUMAN Transgelin-26platelet degranulation,epithelial cell differentiation:extracellular region,cytosol,vesicle,extracellular exosomeO>sp|P37802|TAGL2_HUMAN Transgelin-2 OS=Homo sapiens OX=9606 GN=TAGLN2 PE=1 SV=3P09211GSTP1 GSTP1_HUMANGlutathione S-transferase PQresponse to reactive oxygen species,negative regulation of acute inflammatory response,negative regulation of protein kinase activity,glutathione metabolic process,xenobiotic metabolic process,central nervous system development,negative regulation of biosynthetic process,negative regulation of tumor necrosis factor-mediated signaling pathway,oligodendrocyte development,animal organ regeneration,response to estradiol,negative regulation of interleukin-1 beta production,negative regulation of tumor necrosis factor production,cellular response to insulin stimulus,regulation of stress-activated MAPK cascade,negative regulation of stress-activated MAPK cascade,positive regulation of superoxide anion generation,response to L-ascorbic acid,common myeloid progenitor cell proliferation,nitric oxide storage,negative regulation of apoptotic process,negative regulation of I-kappaB kinase/NF-kappaB signaling,response to amino acid,neutrophil degranulation,negative regulation of MAP kinase activity,negative regulation of MAPK cascade,negative regulation of JUN kinase activity,linoleic acid metabolic process,response to ethanol,negative regulation of fibroblast proliferation,negative regulation of nitric-oxide synthase biosynthetic process,regulation of ERK1 and ERK2 cascade,negative regulation of ERK1 and ERK2 cascade,negative regulation of leukocyte proliferation,cellular response to lipopolysaccharide,cellular response to epidermal growth factor stimulus,cellular response to glucocorticoid stimulus,cellular response to cell-matrix adhesion,negative regulation of monocyte chemotactic protein-1 production,negative regulation of smooth muscle cell chemotaxis,cellular oxidant detoxification,glutathione derivative biosynthetic process,negative regulation of vascular smooth muscle cell proliferation,negative regulation of extrinsic apoptotic signaling pathwayglutathione transferase activity,glutathione peroxidase activity,protein binding,drug binding,JUN kinase binding,kinase regulator activity,S-nitrosoglutathione binding,dinitrosyl-iron complex binding,glutathione binding,nitric oxide bindingextracellular region,extracellular space,intracellular,nucleus,cytoplasm,mitochondrion,cytosol,plasma membrane,vesicle,secretory granule lumen,extracellular exosome,TRAF2-GSTP1 complex,ficolin-1-rich granule lumen]>sp|P09211|GSTP1_HUMAN Glutathione S-transferase P OS=Homo sapiens OX=9606 GN=GSTP1 PE=1 SV=2P55786NPEPPS PSA_HUMAN"Puromycin-sensitive aminopeptidaseprotein polyubiquitination,proteolysis,peptide catabolic process,cellular response to hypoxia,positive regulation of protein targeting to mitochondrionc>sp|P55786|PSA_HUMAN Puromycin-sensitive aminopeptidase OS=Homo sapiens OX=9606 GN=NPEPPS PE=1 SV=2P48740MASP1 MASP1_HUMAN'Mannan-binding lectin serine protease 1ecomplement activation, lectin pathway,proteolysis,receptor-mediated endocytosis,complement activationserine-type endopeptidase activity,calcium ion binding,protein binding,peptidase activity,protein homodimerization activity,calcium-dependent protein binding<extracellular region,extracellular space,nucleoplasm,cytosoli>sp|P48740|MASP1_HUMAN Mannan-binding lectin serine protease 1 OS=Homo sapiens OX=9606 GN=MASP1 PE=1 SV=3Q16881TXNRD1 TRXR1_HUMAN$Thioredoxin reductase 1, cytoplasmicresponse to reactive oxygen species,response to oxygen radical,selenium compound metabolic process,signal transduction,nucleobase-containing small molecule interconversion,cell redox homeostasis,oxidation-reduction process,cellular oxidant detoxificationthioredoxin-disulfide reductase activity,protein binding,electron carrier activity,protein disulfide oxidoreductase activity,flavin adenine dinucleotide binding,methylselenol reductase activity,methylseleninic acid reductase activityHfibrillar center,nucleoplasm,mitochondrion,cytosol,extracellular exosomeg>sp|Q16881|TRXR1_HUMAN Thioredoxin reductase 1, cytoplasmic OS=Homo sapiens OX=9606 GN=TXNRD1 PE=1 SV=3P28074PSMB5 PSB5_HUMANProteasome subunit beta type-5MAPK cascade,protein polyubiquitination,stimulatory C-type lectin receptor signaling pathway,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent,proteolysis,regulation of cellular amino acid metabolic process,response to oxidative stress,negative regulation of G2/M transition of mitotic cell cycle,viral process,protein deubiquitination,anaphase-promoting complex-dependent catabolic process,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process,tumor necrosis factor-mediated signaling pathway,NIK/NF-kappaB signaling,Fc-epsilon receptor signaling pathway,proteasome-mediated ubiquitin-dependent protein catabolic process,regulation of mRNA stability,T cell receptor signaling pathway,negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition,transmembrane transport,Wnt signaling pathway, planar cell polarity pathway,regulation of transcription from RNA polymerase II promoter in response to hypoxia,negative regulation of canonical Wnt signaling pathway,positive regulation of canonical Wnt signaling pathwayHthreonine-type endopeptidase activity,protein binding,peptidase activitygproteasome complex,nucleus,nucleoplasm,centrosome,cytosol,proteasome core complex,extracellular exosome_>sp|P28074|PSB5_HUMAN Proteasome subunit beta type-5 OS=Homo sapiens OX=9606 GN=PSMB5 PE=1 SV=3P25789PSMA4 PSA4_HUMANProteasome subunit alpha type-4proteasome complex,cytoplasmic mRNA processing body,nucleus,nucleoplasm,cytosol,proteasome core complex,proteasome core complex, alpha-subunit complex,intracellular membrane-bounded organelle,extracellular exosome`>sp|P25789|PSA4_HUMAN Proteasome subunit alpha type-4 OS=Homo sapiens OX=9606 GN=PSMA4 PE=1 SV=1Q01995TAGLN TAGL_HUMAN Transgelin8muscle organ development,epithelial cell differentiationK>sp|Q01995|TAGL_HUMAN Transgelin OS=Homo sapiens OX=9606 GN=TAGLN PE=1 SV=4P18669PGAM1 PGAM1_HUMANPhosphoglycerate mutase 1gluconeogenesis,glycolytic process,regulation of glycolytic process,neutrophil degranulation,regulation of pentose-phosphate shunt,respiratory burst,canonical glycolysisbisphosphoglycerate mutase activity,phosphoglycerate mutase activity,protein binding,hydrolase activity,protein kinase binding,2,3-bisphosphoglycerate-dependent phospho< glycerate mutase activityextracellular region,nucleus,cytoplasm,cytosol,membrane,secretory granule lumen,myelin sheath,extracellular exosome,ficolin-1-rich granule lumen[>sp|P18669|PGAM1_HUMAN Phosphoglycerate mutase 1 OS=Homo sapiens OX=9606 GN=PGAM1 PE=1 SV=2P11413G6PD G6PD_HUMAN#Glucose-6-phosphate 1-dehydrogenasehglucose metabolic process,pentose-phosphate shunt,lipid metabolic process,cholesterol biosynthetic process,NADP metabolic process,NADPH regeneration,glutathione metabolic process,pentose-phosphate shunt, oxidative branch,response to iron(III) ion,negative regulation of protein glutathionylation,response to organic cyclic compound,pentose biosynthetic process,substantia nigra development,response to food,cellular response to oxidative stress,erythrocyte maturation,regulation of neuron apoptotic process,response to ethanol,ribose phosphate biosynthetic process,glucose 6-phosphate metabolic process,oxidation-reduction process,negative regulation of cell growth involved in cardiac muscle cell development,positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel,negative regulation of reactive oxygen species metabolic processglucose-6-phosphate dehydrogenase activity,protein binding,glucose binding,identical protein binding,protein homodimerization activity,NADP binding\nucleus,cytoplasm,cytosol,cytoplasmic side of plasma membrane,membrane,extracellular exosomec>sp|P11413|G6PD_HUMAN Glucose-6-phosphate 1-dehydrogenase OS=Homo sapiens OX=9606 GN=G6PD PE=1 SV=4Q14108SCARB2 SCRB2_HUMANLysosome membrane protein 2protein targeting to lysosome,positive regulation of neuron projection development,viral entry into host cell,membrane organization,regulation of endosome organization,regulation of glucosylceramidase activity,Requires Ontology6virus receptor activity,protein binding,enzyme bindinglysosomal membrane,plasma membrane,focal adhesion,membrane,integral component of membrane,clathrin-coated vesicle membrane,late endosome membrane,lysosomal lumen,extracellular exosome^>sp|Q14108|SCRB2_HUMAN Lysosome membrane protein 2 OS=Homo sapiens OX=9606 GN=SCARB2 PE=1 SV=2P29508SERPINB3 SPB3_HUMAN Serpin B3positive regulation of cell proliferation,negative regulation of peptidase activity,positive regulation of epithelial to mesenchymal transition,positive regulation of endopeptidase activity,negative regulation of endopeptidase activity,positive regulation of cell migration,autocrine signaling,paracrine signaling,negative regulation of catalytic activity,neutrophil degranulation,negative regulation of JUN kinase activity,negative regulation of proteolysis,viral entry into host cellvirus receptor activity,protease binding,serine-type endopeptidase inhibitor activity,cysteine-type endopeptidase inhibitor activityextracellular region,extracellular space,nucleus,cytoplasm,cytoplasmic vesicle,vesicle,azurophil granule lumen,extracellular exosomeM>sp|P29508|SPB3_HUMAN Serpin B3 OS=Homo sapiens OX=9606 GN=SERPINB3 PE=1 SV=2Q08554DSC1 DSC1_HUMAN Desmocollin-1uhomophilic cell adhesion via plasma membrane adhesion molecules,keratinization,neutrophil degranulation,cornificationcornified envelope,plasma membrane,gap junction,membrane,integral component of membrane,desmosome,extracellular exosome,ficolin-1-rich granule membraneM>sp|Q08554|DSC1_HUMAN Desmocollin-1 OS=Homo sapiens OX=9606 GN=DSC1 PE=1 SV=2P30041PRDX6 PRDX6_HUMANPeroxiredoxin-6response to reactive oxygen species,lipid catabolic process,hydrogen peroxide catabolic process,neutrophil degranulation,cell redox homeostasis,oxidation-reduction process,cellular oxidant detoxificationglutathione peroxidase activity,protein binding,hydrolase activity,ubiquitin protein ligase binding,cadherin binding,peroxiredoxin activityqextracellular region,extracellular space,cytoplasm,cytosol,membrane,azurophil granule lumen,extracellular exosomeQ>sp|P30041|PRDX6_HUMAN Peroxiredoxin-6 OS=Homo sapiens OX=9606 GN=PRDX6 PE=1 SV=3P07339CTSD CATD_HUMAN Cathepsin Dproteolysis,autophagy,antigen processing and presentation of exogenous peptide antigen via MHC class II,protein catabolic process,collagen catabolic process,neutrophil degranulation|aspartic-type endopeptidase activity,cysteine-type endopeptidase activity,serine-type endopeptidase activity,protein bindingextracellular region,extracellular space,lysosome,specific granule lumen,melanosome,lysosomal lumen,membrane raft,extracellular exosome,tertiary granule lumen,ficolin-1-rich granule lumen,extracellular matrixK>sp|P07339|CATD_HUMAN Cathepsin D OS=Homo sapiens OX=9606 GN=CTSD PE=1 SV=1Q06830PRDX1 PRDX1_HUMANPeroxiredoxin-1uresponse to reactive oxygen species,skeletal system development,retina homeostasis,cell proliferation,removal of superoxide radicals,regulation of stress-activated MAPK cascade,erythrocyte homeostasis,natural killer cell mediated cytotoxicity,regulation of NF-kappaB import into nucleus,hydrogen peroxide catabolic process,cell redox homeostasis,oxidation-reduction processzRNA binding,peroxidase activity,protein binding,thioredoxin peroxidase activity,identical protein binding,cadherin bindingextracellular space,nucleus,cytoplasm,mitochondrion,cytosol,extracellular matrix,melanosome,myelin sheath,extracellular exosomeQ>sp|Q06830|PRDX1_HUMAN Peroxiredoxin-1 OS=Homo sapiens OX=9606 GN=PRDX1 PE=1 SV=1P09525ANXA4 ANXA4_HUMAN Annexin A4Hregulation of transcription from RNA polymerase II promoter,signal transduction,Notch signaling pathway,epithelial cell differentiation,negative regulation of NF-kappaB transcription factor activity,negative regulation of apoptotic process,negative regulation of catalytic activity,negative regulation of interleukin-8 secretionphospholipase inhibitor activity,calcium ion binding,protein binding,calcium-dependent phospholipid binding,identical protein binding,calcium-dependent protein binding,NF-kappaB bindingnucleus,cytoplasm,plasma membrane,cell surface,vesicle membrane,nuclear membrane,perinuclear region of cytoplasm,extracellular exosomeL>sp|P09525|ANXA4_HUMAN Annexin A4 OS=Homo sapiens OX=9606 GN=ANXA4 PE=1 SV=4O15118NPC1 NPC1_HUMAN+NPC intracellular cholesterol transporter 1lprotein glycosylation,receptor-mediated endocytosis,autophagy,lysosomal transport,signal transduction,adult walking behavior,cholesterol metabolic process,bile acid metabolic process,negative regulation of macroautophagy,cholesterol transport,membrane raft organization,cholesterol efflux,response to drug,cholesterol homeostasis,response to cadmium ion,viral entry into host cell,negative regulation of cell death,cellular response to steroid hormone stimulus,cellular response to low-density lipoprotein particle stimulus,establishment of protein localization to membrane,positive regulation of cholesterol homeostasisvirus receptor activity,receptor activity,transmembrane signaling receptor activity,protein binding,sterol transporter activity,cholesterol bindingextracellular region,nuclear envelope,lysosome,lysosomal membrane,endoplasmic reticulum,Golgi apparatus,integral component of plasma membrane,membrane,integral component of membrane,late endosome membrane,membrane raft,perinuclear region of cytoplasm,extracellular exosomek>sp|O15118|NPC1_HUMAN NPC intracellular cholesterol transporter 1 OS=Homo sapiens OX=9606 GN=NPC1 PE=1 SV=2Q12884FAP SEPR_HUMANProlyl endopeptidase FAP'angiogenesis,proteolysis,cell adhesion,regulation of collagen catabolic process,negative regulation of extracellular matrix disassembly,endothelial cell migration,proteolysis involved in cellular protein catabolic process,regulation of fibrinolysis,negative regulation of cell proliferation involved in contact inhibition,positive regulation of cell cycle arrest,mitotic cell cycle arrest,melanocyte proliferation,positive regulation of execution phase of apoptosis,melanocyte apoptotic process,negative regulation of extracellular matrix organizationprotease binding,endopeptidase activity,metalloendopeptidase activity,serine-type endopeptidase activity,integrin binding,prot< ein binding,peptidase activity,serine-type peptidase activity,dipeptidyl-peptidase activity,protein homodimerization activity,protein dimerization activityextracellular space,cytoplasm,plasma membrane,focal adhesion,cell surface,integral component of membrane,lamellipodium,lamellipodium membrane,ruffle membrane,apical part of cell,basal part of cell,invadopodium membraneW>sp|Q12884|SEPR_HUMAN Prolyl endopeptidase FAP OS=Homo sapiens OX=9606 GN=FAP PE=1 SV=5P10809HSPD1 CH60_HUMAN(60 kDa heat shock protein, mitochondrialresponse to hypoxia,detection of misfolded protein,B cell cytokine production,MyD88-dependent toll-like receptor signaling pathway,positive regulation of T cell mediated immune response to tumor cell,response to ischemia,regulation of transcription from RNA polymerase II promoter,'de novo' protein folding,activation of cysteine-type endopeptidase activity involved in apoptotic process,response to unfolded protein,apoptotic mitochondrial changes,response to heat,response to cold,response to activity,viral process,response to lipopolysaccharide,positive regulation of interferon-alpha production,positive regulation of interferon-gamma production,positive regulation of interleukin-10 production,positive regulation of interleukin-12 production,positive regulation of interleukin-6 production,response to ATP,protein refolding,B cell proliferation,T cell activation,B cell activation,response to cocaine,response to drug,response to hydrogen peroxide,positive regulation of macrophage activation,positive regulation of apoptotic process,negative regulation of apoptotic process,negative regulation of neuron apoptotic process,response to estrogen,protein import into mitochondrial intermembrane space,isotype switching to IgG isotypes,positive regulation of inflammatory response,protein stabilization,positive regulation of T cell activation,chaperone mediated protein folding requiring cofactor,chaperone-mediated protein complex assembly,response to glucocorticoid,protein maturation,chaperone-mediated protein folding,negative regulation of apoptotic process in bone marrow,negative regulation of reactive oxygen species biosynthetic process,positive regulation of tumor necrosis factor secretion,positive regulation of interleukin-6 secretionlipopolysaccharide binding,protease binding,p53 binding,DNA replication origin binding,single-stranded DNA binding,RNA binding,double-stranded RNA binding,protein binding,ATP binding,ATPase activity,ubiquitin protein ligase binding,protein complex binding,insulin binding,protein binding involved in protein folding,protein heterodimerization activity,unfolded protein binding,chaperone binding,misfolded protein bindingextracellular space,cytoplasm,mitochondrion,mitochondrial inner membrane,mitochondrial matrix,early endosome,peroxisomal matrix,rough endoplasmic reticulum,Golgi apparatus,cytosol,plasma membrane,clathrin-coated pit,cell surface,membrane,mitochondrial crista,coated vesicle,secretory granule,extracellular matrix,zymogen granule,myelin sheath,protein complex,membrane raft,lipopolysaccharide receptor complex,extracellular exosome,cyclin-dependent protein kinase activating kinase holoenzyme complexi>sp|P10809|CH60_HUMAN 60 kDa heat shock protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPD1 PE=1 SV=2P29401TKT TKT_HUMAN Transketolasexylulose biosynthetic process,pentose-phosphate shunt,pentose-phosphate shunt, non-oxidative branch,regulation of growth,glyceraldehyde-3-phosphate biosynthetic processktransketolase activity,protein binding,protein homodimerization activity,metal ion binding,cofactor bindingenucleoplasm,peroxisome,cytosol,nuclear body,nuclear speck,vesicle,myelin sheath,extracellular exosomeK>sp|P29401|TKT_HUMAN Transketolase OS=Homo sapiens OX=9606 GN=TKT PE=1 SV=3P13647KRT5 K2C5_HUMANKeratin, type II cytoskeletal 5ccytoskeleton organization,epidermis development,keratinization,hemidesmosome assembly,cornificationOstructural constituent of cytoskeleton,protein binding,scaffold protein binding}nucleus,cytoplasm,mitochondrion,cytosol,intermediate filament,plasma membrane,membrane,keratin filament,extracellular exosome_>sp|P13647|K2C5_HUMAN Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3P08572COL4A2 CO4A2_HUMANCollagen alpha-2(IV) chain&angiogenesis,transcription, DNA-templated,negative regulation of angiogenesis,extracellular matrix organization,collagen catabolic process,endodermal cell differentiation,collagen-activated tyrosine kinase receptor signaling pathway,cellular response to transforming growth factor beta stimulus;extracellular matrix structural constituent,protein bindingextracellular region,collagen type IV trimer,extracellular space,endoplasmic reticulum lumen,extracellular matrix,extracellular exosome]>sp|P08572|CO4A2_HUMAN Collagen alpha-2(IV) chain OS=Homo sapiens OX=9606 GN=COL4A2 PE=1 SV=4O15031PLXNB2 PLXB2_HUMAN Plexin-B2neural tube closure,regulation of protein phosphorylation,homophilic cell adhesion via plasma membrane adhesion molecules,negative regulation of cell adhesion,neuroblast proliferation,brain development,regulation of cell shape,positive regulation of neuron projection development,regulation of GTPase activity,positive regulation of axonogenesis,semaphorin-plexin signaling pathway,regulation of neuron migration,protein binding,semaphorin receptor activityHintegral component of plasma membrane,cell surface,extracellular exosomeL>sp|O15031|PLXB2_HUMAN Plexin-B2 OS=Homo sapiens OX=9606 GN=PLXNB2 PE=1 SV=3 P0DMV8;P0DMV9 HSPA1A;HSPA1BHS71A_HUMAN;HS71B_HUMAN9Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1B positive regulation of gene expression,negative regulation of transforming growth factor beta receptor signaling pathway,regulation of protein ubiquitination,negative regulation of protein ubiquitination,positive regulation of proteasomal ubiquitin-dependent protein catabolic process,positive regulation of interleukin-8 production,cellular response to oxidative stress,cellular response to heat,protein refolding,neutrophil degranulation,regulation of mRNA stability,ATP metabolic process,viral entry into host cell,protein stabilization,positive regulation of NF-kappaB transcription factor activity,negative regulation of cell death,cellular heat acclimation,positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway,positive regulation of microtubule nucleation,negative regulation of inclusion body assembly,negative regulation of transcription from RNA polymerase II promoter in response to stress,regulation of cellular response to heat,negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway,regulation of mitotic spindle assembly,negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway,positive regulation of endoribonuclease activity,positive regulation of tumor necrosis factor-mediated signaling pathway,positive regulation of mRNA endonucleolytic cleavage involved in unfolded protein response,negative regulation of extrinsic apoptotic signaling pathway in absence of ligand,regulation of cell death;positive regulation of gene expression,regulation of protein ubiquitination,negative regulation of protein ubiquitination,positive regulation of interleukin-8 production,cellular response to oxidative stress,cellular response to heat,protein refolding,neutrophil degranulation,ATP metabolic process,viral entry into host cell,protein stabilization,positive regulation of NF-kappaB transcription factor activity,negative regulation of cell death,cellular heat acclimation,positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway,positive regulation of microtubule nucleation,negative regulation of inclusion body assembly,regulation of cellular response to heat,regulation of mitotic spindle assembly,positive regulation of tumor necrosis factor-mediated signaling pathway,negative regulation of extrinsic apoptotic signaling pathway in absence of ligand,regulation of cell death RNA polymerase < II transcription corepressor activity,virus receptor activity,G-protein coupled receptor binding,receptor binding,protein binding,ATP binding,ATPase activity,enzyme binding,heat shock protein binding,ubiquitin protein ligase binding,ATPase activity, coupled,histone deacetylase binding,protein binding involved in protein folding,cadherin binding,unfolded protein binding,C3HC4-type RING finger domain binding;virus receptor activity,G-protein coupled receptor binding,receptor binding,protein binding,ATP binding,ATPase activity,enzyme binding,heat shock protein binding,ubiquitin protein ligase binding,ATPase activity, coupled,histone deacetylase binding,protein binding involved in protein folding,unfolded protein binding,C3HC4-type RING finger domain bindingextracellular region,nucleoplasm,cytoplasm,mitochondrion,centrosome,centriole,cytosol,focal adhesion,inclusion body,perinuclear region of cytoplasm,blood microparticle,ficolin-1-rich granule lumen,ubiquitin ligase complex;extracellular region,nucleoplasm,cytoplasm,centrosome,centriole,cytosol,focal adhesion,inclusion body,perinuclear region of cytoplasm,blood microparticle,ficolin-1-rich granule lumen,ubiquitin ligase complex>sp|P0DMV8|HS71A_HUMAN Heat shock 70 kDa protein 1A OS=Homo sapiens OX=9606 GN=HSPA1A PE=1 SV=1;>sp|P0DMV9|HS71B_HUMAN Heat shock 70 kDa protein 1B OS=Homo sapiens OX=9606 GN=HSPA1B PE=1 SV=1Q02413DSG1 DSG1_HUMAN Desmoglein-1dcell-cell junction assembly,homophilic cell adhesion via plasma membrane adhesion molecules,single organismal cell-cell adhesion,calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules,keratinization,response to progesterone,neutrophil degranulation,protein stabilization,maternal process involved in female pregnancy,cornificationQcalcium ion binding,protein binding,toxic substance binding,gamma-catenin bindingcornified envelope,cytosol,plasma membrane,cytoplasmic side of plasma membrane,integral component of membrane,apical plasma membrane,lateral plasma membrane,desmosome,extracellular matrix,extracellular exosome,ficolin-1-rich granule membrane,cell-cell junctionL>sp|Q02413|DSG1_HUMAN Desmoglein-1 OS=Homo sapiens OX=9606 GN=DSG1 PE=1 SV=2P04075ALDOA ALDOA_HUMAN Fructose-bisphosphate aldolase AUplatelet degranulation,fructose metabolic process,gluconeogenesis,glycolytic process,ATP biosynthetic process,striated muscle contraction,actin filament organization,regulation of cell shape,fructose 1,6-bisphosphate metabolic process,neutrophil degranulation,muscle cell cellular homeostasis,protein homotetramerization,canonical glycolysisRNA binding,actin binding,fructose-bisphosphate aldolase activity,protein binding,cytoskeletal protein binding,tubulin binding,identical protein binding,cadherin binding,fructose bindingextracellular region,extracellular space,nucleus,cytosol,actin cytoskeleton,membrane,platelet alpha granule lumen,M band,I band,secretory granule lumen,extracellular exosome,tertiary granule lumen,ficolin-1-rich granule lumenb>sp|P04075|ALDOA_HUMAN Fructose-bisphosphate aldolase A OS=Homo sapiens OX=9606 GN=ALDOA PE=1 SV=2P23142FBLN1 FBLN1_HUMAN Fibulin-1negative regulation of protein phosphorylation,negative regulation of cell adhesion,embryo implantation,positive regulation of peptidase activity,viral process,extracellular matrix organization,negative regulation of ERK1 and ERK2 cascade,blood coagulation, fibrin clot formation,negative regulation of substrate adhesion-dependent cell spreading,negative regulation of cell motility,negative regulation of stem cell proliferation,integrin-mediated signaling pathwayfibronectin binding,extracellular matrix structural constituent,calcium ion binding,protein C-terminus binding,peptidase activator activity,protein complex binding,identical protein binding,fibrinogen bindingextracellular region,proteinaceous extracellular matrix,basement membrane,extracellular space,extracellular exosome,elastic fiber,fibrinogen complex,extracellular matrixK>sp|P23142|FBLN1_HUMAN Fibulin-1 OS=Homo sapiens OX=9606 GN=FBLN1 PE=1 SV=4P02787TF TRFE_HUMANSerotransferrinretina homeostasis,platelet degranulation,cellular iron ion homeostasis,regulation of protein stability,transferrin transport,positive regulation of receptor-mediated endocytosis,iron ion homeostasis,membrane organization,cellular response to iron ion,ferrous iron import into cellprotein binding,ferrous iron binding,ferric iron binding,ferric iron transmembrane transporter activity,transferrin receptor bindingextracellular region,extracellular space,early endosome,late endosome,clathrin-coated pit,basal plasma membrane,cell surface,endosome membrane,apical plasma membrane,endocytic vesicle,clathrin-coated vesicle membrane,extrinsic component of external side of plasma membrane,cytoplasmic vesicle,vesicle,secretory granule lumen,basal part of cell,perinuclear region of cytoplasm,recycling endosome,extracellular exosome,blood microparticle,HFE-transferrin receptor complexM>sp|P02787|TRFE_HUMAN Serotransferrin OS=Homo sapiens OX=9606 GN=TF PE=1 SV=3P06756ITGAV ITAV_HUMANIntegrin alpha-Vangiogenesis,vasculogenesis,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent,cell adhesion,cell-matrix adhesion,positive regulation of cytosolic calcium ion concentration,integrin-mediated signaling pathway,positive regulation of cell proliferation,negative regulation of macrophage derived foam cell differentiation,negative regulation of lipid storage,cell growth,cell migration,extracellular matrix organization,positive regulation of cell migration,cell-substrate adhesion,negative regulation of lipid transport,cell adhesion mediated by integrin,positive regulation of osteoblast proliferation,heterotypic cell-cell adhesion,substrate adhesion-dependent cell spreading,endodermal cell differentiation,apolipoprotein A-I-mediated signaling pathway,apoptotic cell clearance,neutrophil degranulation,positive regulation of MAPK cascade,negative regulation of low-density lipoprotein particle receptor biosynthetic process,positive regulation of cell adhesion,viral entry into host cell,vascular endothelial growth factor receptor signaling pathway,negative regulation of lipoprotein metabolic process,regulation of phagocytosis,leukocyte migration,negative chemotaxis,entry of symbiont into host cell by promotion of host phagocytosis,ERK1 and ERK2 cascade,calcium ion transmembrane transport,extrinsic apoptotic signaling pathway in absence of ligand,regulation of apoptotic cell clearance,negative regulation of entry of bacterium into host cell,negative regulation of extrinsic apoptotic signaling pathwayvirus receptor activity,fibronectin binding,protease binding,receptor binding,voltage-gated calcium channel activity,protein binding,coreceptor activity,peptide binding,metal ion binding,transforming growth factor beta binding,extracellular matrix binding,extracellular matrix protein binding,opsonin binding,protein kinase C binding,fibroblast growth factor binding,C-X3-C chemokine binding,insulin-like growth factor I binding,neuregulin bindingcytosol,plasma membrane,integral component of plasma membrane,focal adhesion,integrin complex,external side of plasma membrane,cell surface,membrane,lamellipodium membrane,filopodium membrane,microvillus membrane,ruffle membrane,integrin alphav-beta3 complex,integrin alphav-beta5 complex,integrin alphav-beta8 complex,specific granule membrane,alphav-beta3 integrin-IGF-1-IGF1R complex,phagocytic vesicle,extracellular exosomeQ>sp|P06756|ITAV_HUMAN Integrin alpha-V OS=Homo sapiens OX=9606 GN=ITGAV PE=1 SV=2P04264KRT1 K2C1_HUMANKeratin, type II cytoskeletal 1complement activation, lectin pathway,retina homeostasis,response to oxidative stress,keratinization,fibrinolysis,neutrophil degranulation,regulation of angiogenesis,negative regulation of inflammatory response,establishment of skin barrier,cornificationSreceptor activity,structural molecule activity,protein binding,carbohydrate bindingextracellular region,extracellular space,nucleus,cytosol,cytoskeleton,plasma membrane,membrane,extracellu< lar matrix,keratin filament,extracellular exosome,blood microparticle,ficolin-1-rich granule lumen_>sp|P04264|K2C1_HUMAN Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6P12109COL6A1 CO6A1_HUMANCollagen alpha-1(VI) chainosteoblast differentiation,cell adhesion,extracellular matrix organization,collagen catabolic process,endodermal cell differentiation,protein heterotrimerization,cellular response to amino acid stimulus&platelet-derived growth factor bindingextracellular region,proteinaceous extracellular matrix,collagen type VI trimer,extracellular space,lysosomal membrane,endoplasmic reticulum lumen,membrane,extracellular matrix,sarcolemma,protein complex,extracellular exosome]>sp|P12109|CO6A1_HUMAN Collagen alpha-1(VI) chain OS=Homo sapiens OX=9606 GN=COL6A1 PE=1 SV=3P35908KRT2 K22E_HUMAN)Keratin, type II cytoskeletal 2 epidermalkeratinocyte development,epidermis development,keratinization,keratinocyte activation,keratinocyte proliferation,intermediate filament organization,keratinocyte migration,cornificationSstructural constituent of cytoskeleton,protein binding,cytoskeletal protein bindingiextracellular space,nucleus,cytosol,intermediate filament,membrane,keratin filament,extracellular exosomei>sp|P35908|K22E_HUMAN Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2P12110COL6A2 CO6A2_HUMANCollagen alpha-2(VI) chainzcell adhesion,response to glucose,extracellular matrix organization,collagen catabolic process,protein heterotrimerizationextracellular region,proteinaceous extracellular matrix,collagen trimer,extracellular space,endoplasmic reticulum lumen,extracellular matrix,sarcolemma,protein complex,extracellular exosome,extracellular vesicle]>sp|P12110|CO6A2_HUMAN Collagen alpha-2(VI) chain OS=Homo sapiens OX=9606 GN=COL6A2 PE=1 SV=4P24821TNC TENA_HUMANTenascinosteoblast differentiation,cell adhesion,negative regulation of cell adhesion,neuromuscular junction development,positive regulation of cell proliferation,response to wounding,response to mechanical stimulus,positive regulation of gene expression,peripheral nervous system axon regeneration,extracellular matrix organization,wound healing,odontogenesis of dentin-containing tooth,response to ethanol,bud outgrowth involved in lung branching,mesenchymal-epithelial cell signaling involved in prostate gland development,prostate gland epithelium morphogenesis,cellular response to retinoic acid,cellular response to vitamin D,response to fibroblast growth factor,cellular response to prostaglandin D stimulussyndecan binding{extracellular region,basement membrane,interstitial matrix,extracellular space,focal adhesion,membrane,extracellular matrixG>sp|P24821|TENA_HUMAN Tenascin OS=Homo sapiens OX=9606 GN=TNC PE=1 SV=3P35555FBN1 FBN1_HUMAN Fibrillin-1qskeletal system development,metanephros development,heart development,extracellular matrix disassembly,extracellular matrix organization,cell adhesion mediated by integrin,sequestering of BMP in extracellular matrix,sequestering of TGFbeta in extracellular matrix,camera-type eye development,negative regulation of osteoclast differentiation,embryonic eye morphogenesis,post-embryonic eye morphogenesis,cellular response to transforming growth factor beta stimulus,regulation of cellular response to growth factor stimulus,cellular response to insulin-like growth factor stimulus,negative regulation of osteoclast developmentintegrin binding,hormone activity,extracellular matrix structural constituent,calcium ion binding,protein binding,heparin binding,extracellular matrix constituent conferring elasticity,protein complex bindingmicrofibril,extracellular region,proteinaceous extracellular matrix,basement membrane,extracellular space,extracellular matrix,extracellular exosomeK>sp|P35555|FBN1_HUMAN Fibrillin-1 OS=Homo sapiens OX=9606 GN=FBN1 PE=1 SV=4Q07954LRP1 LRP1_HUMAN5Prolow-density lipoprotein receptor-related protein 1mretinoid metabolic process,receptor-mediated endocytosis,protein kinase C-activating G-protein coupled receptor signaling pathway,aging,cell proliferation,regulation of extracellular matrix disassembly,positive regulation of cholesterol efflux,negative regulation of neuron projection development,negative regulation of smooth muscle cell migration,cerebral cortex development,negative regulation of Wnt signaling pathway,positive regulation of lipid transport,regulation of cholesterol transport,regulation of phospholipase A2 activity,regulation of actin cytoskeleton organization,aorta morphogenesis,lipoprotein metabolic process,lipoprotein transport,apoptotic cell clearance,negative regulation of neuron apoptotic process,positive regulation of protein transport,beta-amyloid clearance,negative regulation of platelet-derived growth factor receptor-beta signaling pathwayprotease binding,RNA binding,receptor activity,low-density lipoprotein receptor activity,calcium ion binding,protein binding,protein complex binding,apolipoprotein binding,lipoprotein transporter activity,lipoprotein particle receptor bindingnucleolus,lysosomal membrane,endosome,cytosol,plasma membrane,integral component of plasma membrane,clathrin-coated pit,focal adhesion,clathrin-coated vesicle,dendrite,endocytic vesicle membrane,neuronal cell body,receptor complexu>sp|Q07954|LRP1_HUMAN Prolow-density lipoprotein receptor-related protein 1 OS=Homo sapiens OX=9606 GN=LRP1 PE=1 SV=2295 proteins are up-regulated.MIDAS / QuiescentMIDASO75342ALOX12B LX12B_HUMAN&Arachidonate 12-lipoxygenase, 12R-typerprotein lipidation,sphingolipid metabolic process,positive regulation of gene expression,arachidonic acid metabolic process,lipoxygenase pathway,positive regulation of MAPK cascade,linoleic acid metabolic process,ceramide biosynthetic process,hepoxilin biosynthetic process,oxidation-reduction process,establishment of skin barrier,positive regulation of mucus secretionarachidonate 12-lipoxygenase activity,iron ion binding,protein binding,oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen,linoleate 9S-lipoxygenase activityj>sp|O75342|LX12B_HUMAN Arachidonate 12-lipoxygenase, 12R-type OS=Homo sapiens OX=9606 GN=ALOX12B PE=1 SV=1P43652AFM AFAM_HUMANAfaminvitamin transportvitamin E bindingRextracellular region,extracellular space,extracellular exosome,blood microparticleE>sp|P43652|AFAM_HUMAN Afamin OS=Homo sapiens OX=9606 GN=AFM PE=1 SV=1P07358C8B CO8B_HUMAN"Complement component C8 beta chainimmune response,complement activation,complement activation, alternative pathway,complement activation, classical pathway,cytolysis,regulation of complement activationuextracellular region,membrane attack complex,extracellular space,membrane,extracellular exosome,extracellular vesiclea>sp|P07358|CO8B_HUMAN Complement component C8 beta chain OS=Homo sapiens OX=9606 GN=C8B PE=1 SV=3P40189IL6ST IL6RB_HUMAN#Interleukin-6 receptor subunit betapositive regulation of acute inflammatory response,positive regulation of adaptive immune response,glycogen metabolic process,positive regulation of cell proliferation,regulation of Notch signaling pathway,positive regulation of vascular endothelial growth factor production,positive regulation of cardiac muscle hypertrophy,viral process,cytokine-mediated signaling pathway,response to cytokine,interleukin-11-mediated signaling pathway,oncostatin-M-mediated signaling pathway,positive regulation of T cell proliferation,positive regulation of tyrosine phosphorylation of Stat1 protein,positive regulation of tyrosine phosphorylation of Stat3 protein,negative regulation of apoptotic process,positive regulation of osteoblast differentiation,positive regulation of astrocyte differentiation,leukemia inhibitory factor signaling pathway,interleukin-6-mediated signaling pathway,interleukin-27-mediated signaling pathway,ciliary neurotrophic factor-mediated signaling pathwayciliary neurotrophic factor receptor activity,interleukin-11 receptor activity,ciliary neurotr< ophic factor receptor binding,protein binding,growth factor binding,interleukin-11 binding,protein homodimerization activity,interleukin-27 receptor activity,interleukin-6 receptor activity,leukemia inhibitory factor receptor activity,oncostatin-M receptor activity,interleukin-6 receptor binding,interleukin-6 bindingextracellular region,plasma membrane,interleukin-6 receptor complex,oncostatin-M receptor complex,external side of plasma membrane,membrane,dendrite,neuronal cell body,extracellular exosome,ciliary neurotrophic factor receptor complexe>sp|P40189|IL6RB_HUMAN Interleukin-6 receptor subunit beta OS=Homo sapiens OX=9606 GN=IL6ST PE=1 SV=2Q9HCY8S100A14 S10AE_HUMANProtein S100-A14apoptotic process,response to lipopolysaccharide,toll-like receptor 4 signaling pathway,defense response to bacterium,calcium ion homeostasis,positive regulation of granulocyte chemotaxis,positive regulation of monocyte chemotaxis>calcium ion binding,protein binding,chemokine receptor bindingXcytosol,nuclear body,cell junction,perinuclear region of cytoplasm,extracellular exosomeT>sp|Q9HCY8|S10AE_HUMAN Protein S100-A14 OS=Homo sapiens OX=9606 GN=S100A14 PE=1 SV=1O95498VNN2 VNN2_HUMAN$Vascular non-inflammatory molecule 2fC-terminal protein lipidation,movement of cell or subcellular component,pantothenate metabolic processpantetheine hydrolase activityCextracellular region,plasma membrane,anchored component of membraned>sp|O95498|VNN2_HUMAN Vascular non-inflammatory molecule 2 OS=Homo sapiens OX=9606 GN=VNN2 PE=1 SV=3Q92734TFG TFG_HUMAN Protein TFGdsignal transduction,positive regulation of I-kappaB kinase/NF-kappaB signaling,COPII vesicle coatingDsignal transducer activity,protein binding,identical protein binding6Golgi membrane,cytoplasm,cytosol,extracellular exosomeI>sp|Q92734|TFG_HUMAN Protein TFG OS=Homo sapiens OX=9606 GN=TFG PE=1 SV=2O43633CHMP2A CHM2A_HUMAN&Charged multivesicular body protein 2acell separation after cytokinesis,nucleus organization,vacuolar transport,mitotic metaphase plate congression,membrane invagination,exit from mitosis,regulation of centrosome duplication,protein transport,endosomal transport,macroautophagy,viral life cycle,nuclear envelope reassembly,multivesicular body assembly,viral budding via host ESCRT complex,establishment of protein localization,regulation of viral process,protein polymerization,protein homooligomerization,protein heterooligomerization,negative regulation of cell death,regulation of mitotic spindle assembly,positive regulation of viral release from host cell,positive regulation of exosomal secretion,negative regulation of centriole elongation,ESCRT III complex disassemblyKprotein binding,protein domain specific binding,phosphatidylcholine bindingnESCRT III complex,nuclear envelope,cytosol,membrane,membrane coat,late endosome membrane,extracellular exosomei>sp|O43633|CHM2A_HUMAN Charged multivesicular body protein 2a OS=Homo sapiens OX=9606 GN=CHMP2A PE=1 SV=1P06703S100A6 S10A6_HUMANProtein S100-A6lsignal transduction,axonogenesis,ion transmembrane transport,positive regulation of fibroblast proliferationcalcium ion binding,protein binding,tropomyosin binding,zinc ion binding,ion transmembrane transporter activity,protein homodimerization activity,S100 protein binding,calcium-dependent protein bindingruffle,nucleus,nuclear envelope,cytoplasm,cytosol,extrinsic component of cytoplasmic side of plasma membrane,perinuclear region of cytoplasm,extracellular exosomeR>sp|P06703|S10A6_HUMAN Protein S100-A6 OS=Homo sapiens OX=9606 GN=S100A6 PE=1 SV=1O95497VNN1 VNN1_HUMAN Pantetheinaseacute inflammatory response,chronic inflammatory response,C-terminal protein lipidation,movement of cell or subcellular component,inflammatory response,response to oxidative stress,pantothenate metabolic process,single organismal cell-cell adhesion,positive regulation of T cell differentiation in thymus,neutrophil degranulation,innate immune response,negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathwayextracellular region,plasma membrane,integral component of membrane,anchored component of membrane,azurophil granule membrane,extracellular exosomeM>sp|O95497|VNN1_HUMAN Pantetheinase OS=Homo sapiens OX=9606 GN=VNN1 PE=1 SV=2P01011SERPINA3 AACT_HUMANAlpha-1-antichymotrypsinplatelet degranulation,acute-phase response,inflammatory response,negative regulation of endopeptidase activity,regulation of lipid metabolic process,maintenance of gastrointestinal epithelium,neutrophil degranulationHDNA binding,serine-type endopeptidase inhibitor activity,protein bindingextracellular region,extracellular space,intracellular,nucleus,platelet alpha granule lumen,secretory granule lumen,azurophil granule lumen,extracellular exosome,blood microparticle\>sp|P01011|AACT_HUMAN Alpha-1-antichymotrypsin OS=Homo sapiens OX=9606 GN=SERPINA3 PE=1 SV=2P01876IGHA1 IGHA1_HUMAN%Immunoglobulin heavy constant alpha 1retina homeostasis,glomerular filtration,receptor-mediated endocytosis,phagocytosis, recognition,phagocytosis, engulfment,immune response,complement activation, classical pathway,protein-chromophore linkage,antibacterial humoral response,innate immune response,B cell receptor signaling pathway,positive regulation of B cell activation,leukocyte migration,positive regulation of respiratory burst/antigen binding,immunoglobulin receptor bindingextracellular region,extracellular space,external side of plasma membrane,extracellular exosome,monomeric IgA immunoglobulin complex,secretory IgA immunoglobulin complex,secretory dimeric IgA immunoglobulin complex,blood microparticleg>sp|P01876|IGHA1_HUMAN Immunoglobulin heavy constant alpha 1 OS=Homo sapiens OX=9606 GN=IGHA1 PE=1 SV=2Q9BVK6TMED9 TMED9_HUMAN/Transmembrane emp24 domain-containing protein 9ER to Golgi vesicle-mediated transport,retrograde vesicle-mediated transport, Golgi to ER,Golgi organization,positive regulation of organelle organization,COPI coating of Golgi vesicle,protein exit from endoplasmic reticulum,early endosome to Golgi transport protein binding,syntaxin binding3Golgi membrane,endoplasmic reticulum,endoplasmic reticulum membrane,endoplasmic reticulum-Golgi intermediate compartment,Golgi apparatus,integral component of membrane,transport vesicle,trans-Golgi network transport vesicle,endoplasmic reticulum-Golgi intermediate compartment membrane,extracellular exosomeq>sp|Q9BVK6|TMED9_HUMAN Transmembrane emp24 domain-containing protein 9 OS=Homo sapiens OX=9606 GN=TMED9 PE=1 SV=2O60462NRP2 NRP2_HUMAN Neuropilin-2angiogenesis,positive regulation of endothelial cell proliferation,cell adhesion,axon guidance,positive regulation of endothelial cell migration,nerve development,vascular endothelial growth factor signaling pathway,vascular endothelial growth factor receptor signaling pathway,axon extension involved in axon guidance,sympathetic ganglion development,sympathetic neuron projection extension,sympathetic neuron projection guidance,semaphorin-plexin signaling pathway involved in neuron projection guidancereceptor activity,vascular endothelial growth factor-activated receptor activity,heparin binding,semaphorin receptor activity,growth factor binding,cytokine binding,metal ion bindinghsemaphorin receptor complex,extracellular region,plasma membrane,membrane,integral component of membraneL>sp|O60462|NRP2_HUMAN Neuropilin-2 OS=Homo sapiens OX=9606 GN=NRP2 PE=1 SV=3Q9HAB3SLC52A2 S52A2_HUMAN:Solute carrier family 52, riboflavin transporter, member 2Lriboflavin metabolic process,riboflavin transport,viral entry into host cellGvirus receptor activity,protein binding,riboflavin transporter activity~>sp|Q9HAB3|S52A2_HUMAN Solute carrier family 52, riboflavin transporter, member 2 OS=Homo sapiens OX=9606 GN=SLC52A2 PE=1 SV=1P68036UBE2L3 UB2L3_HUMAN"Ubiquitin-conjugating enzyme E2 L3pprotein polyubiquitination,transcription, DNA-templated,regulation of transcription, DNA-templated,cellular protein modification process,ubiquitin-dependent protein catabolic process,cell prolife< ration,protein ubiquitination,positive regulation of protein ubiquitination,protein ubiquitination involved in ubiquitin-dependent protein catabolic process,cell cycle phase transition,positive regulation of ubiquitin-protein transferase activity,protein K11-linked ubiquitination,cellular response to steroid hormone stimulus,cellular response to glucocorticoid stimulus,positive regulation of protein targeting to mitochondriontranscription coactivator activity,RNA binding,ubiquitin-protein transferase activity,protein binding,ATP binding,enzyme binding,ubiquitin protein ligase binding,ubiquitin conjugating enzyme activity,ubiquitin-protein transferase activator activityTubiquitin ligase complex,nucleus,nucleoplasm,cytoplasm,cytosol,extracellular exosomee>sp|P68036|UB2L3_HUMAN Ubiquitin-conjugating enzyme E2 L3 OS=Homo sapiens OX=9606 GN=UBE2L3 PE=1 SV=1Q6UX71PLXDC2 PXDC2_HUMAN"Plexin domain-containing protein 2e>sp|Q6UX71|PXDC2_HUMAN Plexin domain-containing protein 2 OS=Homo sapiens OX=9606 GN=PLXDC2 PE=1 SV=1Q15286RAB35 RAB35_HUMANRas-related protein Rab-35Ucytokinesis,small GTPase mediated signal transduction,protein localization,protein transport,endosomal transport,antigen processing and presentation,neuron projection development,endocytic recycling,protein localization to endosome,plasma membrane to endosome transport,membrane organization,cellular response to nerve growth factor stimuluseGTPase activity,protein binding,GTP binding,phosphatidylinositol-4,5-bisphosphate binding,GDP bindingmitochondrion,cytosol,plasma membrane,clathrin-coated pit,endosome membrane,clathrin-coated vesicle membrane,cell projection membrane,melanosome,intercellular bridge,clathrin-coated endocytic vesicle,recycling endosome membrane,extracellular exosome\>sp|Q15286|RAB35_HUMAN Ras-related protein Rab-35 OS=Homo sapiens OX=9606 GN=RAB35 PE=1 SV=1Q8N697SLC15A4 S15A4_HUMAN!Solute carrier family 15 member 4xion transport,oligopeptide transport,protein transport,proton transport,neutrophil degranulation,transmembrane transport!peptide:proton symporter activity[lysosomal membrane,plasma membrane,integral component of membrane,specific granule membranee>sp|Q8N697|S15A4_HUMAN Solute carrier family 15 member 4 OS=Homo sapiens OX=9606 GN=SLC15A4 PE=1 SV=1Q9NZ08ERAP1 ERAP1_HUMAN&Endoplasmic reticulum aminopeptidase 1angiogenesis,adaptive immune response,antigen processing and presentation of peptide antigen via MHC class I,membrane protein ectodomain proteolysis,signal transduction,cell-cell signaling,regulation of blood pressure,response to bacterium,antigen processing and presentation of endogenous peptide antigen via MHC class I,peptide catabolic process,regulation of innate immune response,fat cell differentiation,positive regulation of angiogenesisendopeptidase activity,aminopeptidase activity,interleukin-6 receptor binding,interleukin-1, Type II receptor binding,protein binding,metalloexopeptidase activity,zinc ion binding,peptide binding,metalloaminopeptidase activityextracellular region,extracellular space,endoplasmic reticulum,endoplasmic reticulum lumen,endoplasmic reticulum membrane,cytosol,membrane,integral component of membrane,extracellular exosomeh>sp|Q9NZ08|ERAP1_HUMAN Endoplasmic reticulum aminopeptidase 1 OS=Homo sapiens OX=9606 GN=ERAP1 PE=1 SV=3Q68CP4HGSNAT HGNAT_HUMAN/Heparan-alpha-glucosaminide N-acetyltransferasehglycosaminoglycan catabolic process,lysosomal transport,neutrophil degranulation,protein oligomerizationgheparan-alpha-glucosaminide N-acetyltransferase activity,transferase activity, transferring acyl groupsulysosomal membrane,plasma membrane,integral component of membrane,specific granule membrane,tertiary granule membraner>sp|Q68CP4|HGNAT_HUMAN Heparan-alpha-glucosaminide N-acetyltransferase OS=Homo sapiens OX=9606 GN=HGSNAT PE=1 SV=2Q9UEY8ADD3 ADDG_HUMAN Gamma-adducin1cytoskeleton organization,transmembrane transportGactin binding,structural constituent of cytoskeleton,calmodulin bindingcondensed nuclear chromosome,nucleoplasm,cytosol,cytoskeleton,plasma membrane,brush border,cell-cell junction,cell cortex,postsynaptic density,membraneM>sp|Q9UEY8|ADDG_HUMAN Gamma-adducin OS=Homo sapiens OX=9606 GN=ADD3 PE=1 SV=1P68402PAFAH1B2 PA1B2_HUMAN<Platelet-activating factor acetylhydrolase IB subunit alpha2lipid metabolic process,spermatogenesis,brain development,lipid catabolic process,positive regulation of macroautophagy,neutrophil degranulation1-alkyl-2-acetylglycerophosphocholine esterase activity,phospholipase A2 activity,protein binding,protein homodimerization activity,protein heterodimerization activity,platelet-activating factor acetyltransferase activityfibrillar center,extracellular region,nucleolus,cytoplasm,cytosol,plasma membrane,secretory granule lumen,extracellular exosome,ficolin-1-rich granule lumen>sp|P68402|PA1B2_HUMAN Platelet-activating factor acetylhydrolase IB subunit alpha2 OS=Homo sapiens OX=9606 GN=PAFAH1B2 PE=1 SV=1P53985SLC16A1 MOT1_HUMANMonocarboxylate transporter 1Epyruvate metabolic process,lipid metabolic process,monocarboxylic acid transport,mevalonate transport,response to food,plasma membrane lactate transport,glucose homeostasis,regulation of insulin secretion,leukocyte migration,centrosome organization,behavioral response to nutrient,cellular response to organic cyclic compoundmonocarboxylic acid transmembrane transporter activity,lactate transmembrane transporter activity,mevalonate transmembrane transporter activity,symporter activity,protein homodimerization activity,organic cyclic compound bindingmitochondrion,centrosome,plasma membrane,integral component of plasma membrane,membrane,integral component of membrane,cell junction,intracellular membrane-bounded organelle,extracellular exosome`>sp|P53985|MOT1_HUMAN Monocarboxylate transporter 1 OS=Homo sapiens OX=9606 GN=SLC16A1 PE=1 SV=3P01040CSTA CYTA_HUMAN Cystatin-Anegative regulation of peptidase activity,negative regulation of endopeptidase activity,single organismal cell-cell adhesion,peptide cross-linking,keratinocyte differentiation,negative regulation of proteolysis,cornificationvprotease binding,cysteine-type endopeptidase inhibitor activity,structural molecule activity,protein binding, bridgingccornified envelope,extracellular space,cytoplasm,cytosol,extracellular matrix,extracellular exosomeJ>sp|P01040|CYTA_HUMAN Cystatin-A OS=Homo sapiens OX=9606 GN=CSTA PE=1 SV=1Q5T9L3WLS WLS_HUMANProtein wntless homologmesoderm formation,intracellular protein transport,anterior/posterior axis specification,Wnt signaling pathway,positive regulation of Wnt signaling pathway,midbrain development,hindbrain development,exocrine pancreas development,positive regulation of I-kappaB kinase/NF-kappaB signaling,Wnt protein secretion,positive regulation of Wnt protein secretion,positive regulation of canonical Wnt signaling pathway^signal transducer activity,protein binding,Wnt-protein binding,mu-type opioid receptor binding'Golgi membrane,early endosome,endoplasmic reticulum,endoplasmic reticulum membrane,Golgi apparatus,trans-Golgi network,plasma membrane,integral component of membrane,endocytic vesicle membrane,cytoplasmic vesicle,early endosome membrane,dendrite membrane,dendrite cytoplasm,extracellular exosomeU>sp|Q5T9L3|WLS_HUMAN Protein wntless homolog OS=Homo sapiens OX=9606 GN=WLS PE=1 SV=2 E9PAV3;Q13765NACANACAM_HUMAN;NACA_HUMANNascent polypeptide-associated complex subunit alpha, muscle-specific form;Nascent polypeptide-associated complex subunit alphaHtranscription, DNA-templated,regulation of transcription, DNA-templated; DNA binding;nucleus,cytoplasm;>sp|E9PAV3|NACAM_HUMAN Nascent polypeptide-associated complex subunit alpha, muscle-specific form OS=Homo sapiens OX=9606 GN=NACA PE=1 SV=1;>sp|Q13765|NACA_HUMAN Nascent polypeptide-associated complex subunit alpha OS=Homo sapiens OX=9606 GN=NACA PE=1 SV=1Q7Z7N9TMEM179B T179B_HUMANTransmembrane protein 179Bnucleolus,plasma membrane,integral component of membrane,nuclear speck,secretory granule membrane,azu< rophil granule membrane,ficolin-1-rich granule membrane_>sp|Q7Z7N9|T179B_HUMAN Transmembrane protein 179B OS=Homo sapiens OX=9606 GN=TMEM179B PE=1 SV=1Q99439CNN2 CNN2_HUMAN Calponin-2cytoskeleton organization,actomyosin structure organization,regulation of actin filament-based process,neutrophil degranulation,cellular response to mechanical stimulus1actin binding,calmodulin binding,cadherin bindingstress fiber,extracellular region,cytoskeleton,cell-cell junction,focal adhesion,membrane,specific granule lumen,extracellular exosome,tertiary granule lumenJ>sp|Q99439|CNN2_HUMAN Calponin-2 OS=Homo sapiens OX=9606 GN=CNN2 PE=1 SV=4P40261NNMT NNMT_HUMAN Nicotinamide N-methyltransferaseresponse to organonitrogen compound,animal organ regeneration,methylation,NAD biosynthesis via nicotinamide riboside salvage pathway,response to drugOnicotinamide N-methyltransferase activity,pyridine N-methyltransferase activity`>sp|P40261|NNMT_HUMAN Nicotinamide N-methyltransferase OS=Homo sapiens OX=9606 GN=NNMT PE=1 SV=1Q15904ATP6AP1 VAS1_HUMANV-type proton ATPase subunit S1insulin receptor signaling pathway,ATP hydrolysis coupled proton transport,proton transport,transferrin transport,ion transmembrane transport,positive regulation of osteoblast differentiation,positive regulation of bone resorption,pH reduction,positive regulation of exocytosis,establishment of organelle localization,positive regulation of ERK1 and ERK2 cascade,positive regulation of osteoclast developmenttransporter activity,ATP binding,Rab GTPase binding,proton-transporting ATP synthase activity, rotational mechanism,proton-transporting ATPase activity, rotational mechanismendoplasmic reticulum membrane,endosome membrane,integral component of membrane,proton-transporting two-sector ATPase complex,endoplasmic reticulum-Golgi intermediate compartment membrane,proton-transporting V-type ATPase, V1 domain,extracellular exosomeb>sp|Q15904|VAS1_HUMAN V-type proton ATPase subunit S1 OS=Homo sapiens OX=9606 GN=ATP6AP1 PE=1 SV=2"P06899;P23527;P33778;Q16778;Q8N257 H2BC11;H2BC17;H2BC3;H2BC21;H2BU1;H2B1J_HUMAN;H2B1O_HUMAN;H2B1B_HUMAN;H2B2E_HUMAN;H2B3B_HUMANhHistone H2B type 1-J;Histone H2B type 1-O;Histone H2B type 1-B;Histone H2B type 2-E;Histone H2B type 3-Binnate immune response in mucosa,nucleosome assembly,protein ubiquitination,antibacterial humoral response,defense response to Gram-positive bacterium;nucleosome assembly,protein ubiquitination;nucleosome assembly,protein ubiquitination;innate immune response in mucosa,nucleosome assembly,antibacterial humoral response,defense response to Gram-positive bacterium;nucleosome assemblyDNA binding,protein heterodimerization activity;DNA binding,protein heterodimerization activity;DNA binding,protein binding,protein heterodimerization activity;DNA binding,protein heterodimerization activity;molecular_function,DNA binding,protein heterodimerization activity%nucleosome,extracellular space,nucleus,nucleoplasm,cytosol;nucleosome,nucleus,nucleoplasm,cytosol;nuclear chromosome, telomeric region,nucleosome,nucleus,nucleoplasm,cytosol;nucleosome,extracellular space,nucleus,nucleoplasm,cytosol,extracellular exosome;nucleosome,nucleus,nucleoplasm,cytosol 3;3;2;3;3>sp|P06899|H2B1J_HUMAN Histone H2B type 1-J OS=Homo sapiens OX=9606 GN=H2BC11 PE=1 SV=3;>sp|P23527|H2B1O_HUMAN Histone H2B type 1-O OS=Homo sapiens OX=9606 GN=H2BC17 PE=1 SV=3;>sp|P33778|H2B1B_HUMAN Histone H2B type 1-B OS=Homo sapiens OX=9606 GN=H2BC3 PE=1 SV=2;>sp|Q16778|H2B2E_HUMAN Histone H2B type 2-E OS=Homo sapiens OX=9606 GN=H2BC21 PE=1 SV=3;>sp|Q8N257|H2B3B_HUMAN Histone H2B type 3-B OS=Homo sapiens OX=9606 GN=H2BU1 PE=1 SV=3P49419ALDH7A1 AL7A1_HUMAN,Alpha-aminoadipic semialdehyde dehydrogenasecellular aldehyde metabolic process,lysine catabolic process,sensory perception of sound,glycine betaine biosynthetic process from choline,choline catabolic process,oxidation-reduction processaldehyde dehydrogenase (NAD) activity,L-aminoadipate-semialdehyde dehydrogenase activity,protein binding,betaine-aldehyde dehydrogenase activityHnucleus,mitochondrion,mitochondrial matrix,cytosol,extracellular exosomep>sp|P49419|AL7A1_HUMAN Alpha-aminoadipic semialdehyde dehydrogenase OS=Homo sapiens OX=9606 GN=ALDH7A1 PE=1 SV=5Q9BR76CORO1B COR1B_HUMAN Coronin-1Bcell migration,actin cytoskeleton organization,ruffle organization,regulation of Arp2/3 complex-mediated actin nucleation,negative regulation of Arp2/3 complex-mediated actin nucleation,endothelial cell chemotaxis,cellular response to platelet-derived growth factor stimulus,wound healing,actin filament bundle assembly,negative regulation of smooth muscle cell chemotaxis,actin filament branching,protein localization to cell leading edge,positive regulation of lamellipodium morphogenesishprotein binding,identical protein binding,cadherin binding,actin filament binding,Arp2/3 complex bindingstress fiber,cytoplasm,cytosol,actin filament,plasma membrane,focal adhesion,lamellipodium,cell leading edge,perinuclear region of cytoplasm,extracellular exosome,cell peripheryM>sp|Q9BR76|COR1B_HUMAN Coronin-1B OS=Homo sapiens OX=9606 GN=CORO1B PE=1 SV=1Q8WWB7GLMP GLMP_HUMAN'Glycosylated lysosomal membrane proteinmintracellular receptor signaling pathway,positive regulation of transcription from RNA polymerase II promoter transcription factor activity, sequence-specific DNA binding,RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding,ligand-dependent nuclear receptor transcription coactivator activity,transcription regulatory region DNA bindingJnucleus,lysosome,lysosomal membrane,cytosol,integral component of membraneg>sp|Q8WWB7|GLMP_HUMAN Glycosylated lysosomal membrane protein OS=Homo sapiens OX=9606 GN=GLMP PE=1 SV=1P01859IGHG2 IGHG2_HUMAN%Immunoglobulin heavy constant gamma 2:proteolysis,phagocytosis, recognition,phagocytosis, engulfment,complement activation,complement activation, classical pathway,Fc-gamma receptor signaling pathway involved in phagocytosis,defense response to bacterium,innate immune response,B cell receptor signaling pathway,positive regulation of B cell activationbantigen binding,serine-type endopeptidase activity,protein binding,immunoglobulin receptor bindingextracellular region,extracellular space,external side of plasma membrane,immunoglobulin complex, circulating,extracellular exosome,blood microparticleg>sp|P01859|IGHG2_HUMAN Immunoglobulin heavy constant gamma 2 OS=Homo sapiens OX=9606 GN=IGHG2 PE=1 SV=2P02766TTR TTHY_HUMAN Transthyretinretinoid metabolic process,transport,extracellular matrix organization,retinol metabolic process,neutrophil degranulation,cellular protein metabolic process,thyroid hormone transport,purine nucleobase metabolic processvhormone activity,protein binding,identical protein binding,protein heterodimerization activity,thyroid hormone bindingfextracellular region,extracellular space,azurophil granule lumen,protein complex,extracellular exosomeL>sp|P02766|TTHY_HUMAN Transthyretin OS=Homo sapiens OX=9606 GN=TTR PE=1 SV=1P22735TGM1 TGM1_HUMAN-Protein-glutamine gamma-glutamyltransferase Kcellular protein modification process,positive regulation of keratinocyte proliferation,peptide cross-linking,keratinocyte differentiation,cell envelope organization,positive regulation of cell cycle,cornificationVprotein-glutamine gamma-glutamyltransferase activity,protein binding,metal ion binding`cornified envelope,cytosol,plasma membrane,intrinsic component of membrane,extracellular exosomem>sp|P22735|TGM1_HUMAN Protein-glutamine gamma-glutamyltransferase K OS=Homo sapiens OX=9606 GN=TGM1 PE=1 SV=4Q9HD45TM9SF3 TM9S3_HUMAN$Transmembrane 9 superfamily member 3g>sp|Q9HD45|TM9S3_HUMAN Transmembrane 9 superfamily member 3 OS=Homo sapiens OX=9606 GN=TM9SF3 PE=1 SV=2O14828SCAMP3 SCAM3_HUMAN/Secretory carrier-associated membrane protein 3Qpost-Golgi vesicle-mediated transport,protein transport,response to retinoic acid ubiquitin protein ligase bindinglGolgi membrane,integral component of membrane,intracellular< membrane-bounded organelle,extracellular exosomer>sp|O14828|SCAM3_HUMAN Secretory carrier-associated membrane protein 3 OS=Homo sapiens OX=9606 GN=SCAMP3 PE=1 SV=3Q9NVJ2ARL8B ARL8B_HUMAN'ADP-ribosylation factor-like protein 8Bocell cycle,chromosome segregation,small GTPase mediated signal transduction,lysosome localization,cell divisionbGTPase activity,protein binding,GTP binding,GDP binding,alpha-tubulin binding,beta-tubulin bindingjcytoplasm,membrane,midbody,late endosome membrane,spindle midzone,extracellular exosome,lysosomal membranei>sp|Q9NVJ2|ARL8B_HUMAN ADP-ribosylation factor-like protein 8B OS=Homo sapiens OX=9606 GN=ARL8B PE=1 SV=1P08603CFH CFAH_HUMANComplement factor Hdcomplement activation,complement activation, alternative pathway,regulation of complement activationDprotein binding,heparin binding,heparan sulfate proteoglycan bindingR>sp|P08603|CFAH_HUMAN Complement factor H OS=Homo sapiens OX=9606 GN=CFH PE=1 SV=4P49768PSEN1 PSN1_HUMAN Presenilin-1 autophagosome assembly,negative regulation of transcription from RNA polymerase II promoter,activation of MAPKK activity,blood vessel development,cell fate specification,somitogenesis,neuron migration,positive regulation of receptor recycling,heart looping,hematopoietic progenitor cell differentiation,T cell activation involved in immune response,neural retina development,protein glycosylation,membrane protein ectodomain proteolysis,mitochondrial transport,cellular response to DNA damage stimulus,response to oxidative stress,negative regulation of epidermal growth factor-activated receptor activity,Notch signaling pathway,Notch receptor processing,memory,post-embryonic development,protein transport,L-glutamate transport,choline transport,synaptic vesicle targeting,single organismal cell-cell adhesion,protein processing,cerebral cortex cell migration,Cajal-Retzius cell differentiation,dorsal/ventral neural tube patterning,embryonic limb morphogenesis,positive regulation of proteasomal ubiquitin-dependent protein catabolic process,endoplasmic reticulum calcium ion homeostasis,beta-amyloid formation,intracellular signal transduction,regulation of phosphorylation,amyloid precursor protein metabolic process,amyloid precursor protein catabolic process,myeloid dendritic cell differentiation,positive regulation of apoptotic process,negative regulation of apoptotic process,positive regulation of catalytic activity,neutrophil degranulation,regulation of protein binding,positive regulation of MAP kinase activity,negative regulation of neuron apoptotic process,skin morphogenesis,positive regulation of transcription, DNA-templated,regulation of synaptic plasticity,thymus development,neuron development,skeletal system morphogenesis,brain morphogenesis,beta-amyloid metabolic process,epithelial cell proliferation,negative regulation of axonogenesis,positive regulation of coagulation,T cell receptor signaling pathway,neuron apoptotic process,negative regulation of ubiquitin-protein transferase activity,smooth endoplasmic reticulum calcium ion homeostasis,regulation of synaptic transmission, glutamatergic,canonical Wnt signaling pathway,regulation of resting membrane potential,regulation of canonical Wnt signaling pathway,positive regulation of dendritic spine development,calcium ion transmembrane transport,negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process,negative regulation of apoptotic signaling pathwayendopeptidase activity,calcium channel activity,protein binding,beta-catenin binding,PDZ domain binding,aspartic endopeptidase activity, intramembrane cleaving,cadherin binding[Golgi membrane,kinetochore,nucleus,nuclear outer membrane,mitochondrion,mitochondrial inner membrane,endoplasmic reticulum,endoplasmic reticulum membrane,smooth endoplasmic reticulum,rough endoplasmic reticulum,Golgi apparatus,centrosome,plasma membrane,integral component of plasma membrane,cell cortex,cell surface,membrane,integral component of membrane,aggresome,Z disc,cell junction,axon,growth cone,neuromuscular junction,nuclear membrane,ciliary rootlet,azurophil granule membrane,neuronal cell body,dendritic shaft,membrane raft,perinuclear region of cytoplasm,gamma-secretase complex,presynapseM>sp|P49768|PSN1_HUMAN Presenilin-1 OS=Homo sapiens OX=9606 GN=PSEN1 PE=1 SV=1Q14344GNA13 GNA13_HUMAN3Guanine nucleotide-binding protein subunit alpha-13+patterning of blood vessels,in utero embryonic development,movement of cell or subcellular component,signal transduction,adenylate cyclase-activating G-protein coupled receptor signaling pathway,positive regulation of cytosolic calcium ion concentration,Rho protein signal transduction,regulation of cell shape,cell differentiation,platelet activation,regulation of cell migration,activation of phospholipase D activity,positive regulation of apoptotic process,positive regulation of GTPase activity,regulation of small GTPase mediated signal transduction GTPase activity,signal transducer activity,guanyl-nucleotide exchange factor activity,Rho guanyl-nucleotide exchange factor activity,protein binding,GTP binding,G-protein beta/gamma-subunit complex binding,type 1 angiotensin receptor binding,D5 dopamine receptor binding,metal ion bindingnucleus,cytosol,heterotrimeric G-protein complex,plasma membrane,focal adhesion,membrane,brush border membrane,melanosome,extracellular exosomeu>sp|Q14344|GNA13_HUMAN Guanine nucleotide-binding protein subunit alpha-13 OS=Homo sapiens OX=9606 GN=GNA13 PE=1 SV=2P52788SMS SPSY_HUMANSpermine synthaseVmethionine metabolic process,polyamine metabolic process,spermine biosynthetic processspermine synthase activityP>sp|P52788|SPSY_HUMAN Spermine synthase OS=Homo sapiens OX=9606 GN=SMS PE=1 SV=2P02763ORM1 A1AG1_HUMANAlpha-1-acid glycoprotein 1platelet degranulation,regulation of immune system process,acute-phase response,inflammatory response,negative regulation of interleukin-6 production,negative regulation of tumor necrosis factor production,neutrophil degranulationextracellular region,extracellular space,platelet alpha granule lumen,specific granule lumen,extracellular exosome,blood microparticle,tertiary granule lumen\>sp|P02763|A1AG1_HUMAN Alpha-1-acid glycoprotein 1 OS=Homo sapiens OX=9606 GN=ORM1 PE=1 SV=1Q13393PLD1 PLD1_HUMANPhospholipase D1phosphatidic acid biosynthetic process,chemotaxis,small GTPase mediated signal transduction,Ras protein signal transduction,lipid catabolic process,regulation of microvillus assembly,neutrophil degranulation,inositol lipid-mediated signaling,cell motilityphospholipase D activity,protein binding,phosphatidylinositol binding,N-acylphosphatidylethanolamine-specific phospholipase D activityGolgi membrane,lysosomal membrane,endosome,endoplasmic reticulum membrane,Golgi apparatus,plasma membrane,membrane,apical plasma membrane,endocytic vesicle,late endosome membrane,specific granule membrane,perinuclear region of cytoplasm,tertiary granule membraneP>sp|Q13393|PLD1_HUMAN Phospholipase D1 OS=Homo sapiens OX=9606 GN=PLD1 PE=1 SV=1Q14525KRT33B KT33B_HUMAN Keratin, type I cuticular Ha3-II-aging,keratinization,hair cycle,cornificationc>sp|Q14525|KT33B_HUMAN Keratin, type I cuticular Ha3-II OS=Homo sapiens OX=9606 GN=KRT33B PE=1 SV=3O60637TSPAN3 TSN3_HUMAN Tetraspanin-3:cell surface receptor signaling pathway,biological_processO>sp|O60637|TSN3_HUMAN Tetraspanin-3 OS=Homo sapiens OX=9606 GN=TSPAN3 PE=2 SV=1Q5D862FLG2 FILA2_HUMAN Filaggrin-26neutrophil degranulation,establishment of skin barrierMstructural molecule activity,calcium ion binding,transition metal ion bindingSextracellular region,nucleus,cytoplasm,extracellular exosome,tertiary granule lumenL>sp|Q5D862|FILA2_HUMAN Filaggrin-2 OS=Homo sapiens OX=9606 GN=FLG2 PE=1 SV=1P24593IGFBP5 IBP5_HUMAN,Insulin-like growth factor-binding protein 5*regulation of cell growth,osteoblast differentiation,glucose metabolic process,signal transduction,female pregnancy,aging,regulation of glucose metabolic process,negative regulation of smooth muscle cell migration,negative < regulation of translation,negative regulation of cell migration,hair follicle morphogenesis,intracellular signal transduction,glucose homeostasis,positive regulation of insulin-like growth factor receptor signaling pathway,negative regulation of insulin-like growth factor receptor signaling pathway,cellular protein metabolic process,type B pancreatic cell proliferation,negative regulation of osteoblast differentiation,negative regulation of growth,lung alveolus development,negative regulation of smooth muscle cell proliferation,striated muscle cell differentiation,positive regulation of protein kinase B signaling,mammary gland involution,response to growth hormone,cellular response to cAMP,cellular response to organic cyclic compound,negative regulation of muscle tissue development,negative regulation of skeletal muscle hypertrophynfibronectin binding,protein binding,insulin-like growth factor I binding,insulin-like growth factor II bindingextracellular region,intracellular,insulin-like growth factor binding protein complex,insulin-like growth factor ternary complexn>sp|P24593|IBP5_HUMAN Insulin-like growth factor-binding protein 5 OS=Homo sapiens OX=9606 GN=IGFBP5 PE=1 SV=1P62750RPL23A RL23A_HUMAN60S ribosomal protein L23aribosomal large subunit assembly,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,rRNA processing,translation,translational initiation,SRP-dependent cotranslational protein targeting to membrane,cell proliferation,viral transcriptiononucleotide binding,RNA binding,structural constituent of ribosome,protein binding,rRNA binding,cadherin bindinginucleus,nucleolus,cytoplasm,cytosol,cytosolic large ribosomal subunit,extracellular exosome,TORC2 complex]>sp|P62750|RL23A_HUMAN 60S ribosomal protein L23a OS=Homo sapiens OX=9606 GN=RPL23A PE=1 SV=1P52823STC1 STC1_HUMANStanniocalcin-1kossification,endothelial cell morphogenesis,growth plate cartilage axis specification,cellular calcium ion homeostasis,embryo implantation,negative regulation of endothelial cell migration,negative regulation of cell migration,response to vitamin D,chondrocyte proliferation,regulation of anion transport,decidualization,negative regulation of calcium ion transport,bone development,cellular response to cAMP,cellular response to glucocorticoid stimulus,cellular response to hypoxia,regulation of cardiac muscle cell contraction,positive regulation of calcium ion import,negative regulation of renal phosphate excretion<extracellular space,nucleus,cytoplasm,apical plasma membraneO>sp|P52823|STC1_HUMAN Stanniocalcin-1 OS=Homo sapiens OX=9606 GN=STC1 PE=1 SV=1Q5VW32BROX BROX_HUMAN#BRO1 domain-containing protein BROXc>sp|Q5VW32|BROX_HUMAN BRO1 domain-containing protein BROX OS=Homo sapiens OX=9606 GN=BROX PE=1 SV=1Q15631TSN TSN_HUMANTransliniDNA recombination,RNA metabolic process,gene silencing by RNA,nucleic acid phosphodiester bond hydrolysisDNA binding,single-stranded DNA binding,mRNA binding,endonuclease activity,protein binding,protein complex binding,identical protein binding,sequence-specific DNA bindingF>sp|Q15631|TSN_HUMAN Translin OS=Homo sapiens OX=9606 GN=TSN PE=1 SV=1P01834IGKC IGKC_HUMANImmunoglobulin kappa constantretina homeostasis,proteolysis,receptor-mediated endocytosis,phagocytosis, recognition,phagocytosis, engulfment,immune response,complement activation,complement activation, classical pathway,Fc-epsilon receptor signaling pathway,Fc-gamma receptor signaling pathway involved in phagocytosis,defense response to bacterium,innate immune response,regulation of immune response,B cell receptor signaling pathway,positive regulation of B cell activation,leukocyte migrationRantigen binding,serine-type endopeptidase activity,immunoglobulin receptor bindingextracellular region,extracellular space,plasma membrane,external side of plasma membrane,immunoglobulin complex, circulating,extracellular exosome,blood microparticle]>sp|P01834|IGKC_HUMAN Immunoglobulin kappa constant OS=Homo sapiens OX=9606 GN=IGKC PE=1 SV=2Q15365PCBP1 PCBP1_HUMANPoly(rC)-binding protein 1mRNA splicing, via spliceosome,gene expression,viral RNA genome replication,positive regulation of transcription from RNA polymerase II promoterRNA polymerase II transcription factor activity, sequence-specific DNA binding,single-stranded DNA binding,RNA binding,mRNA binding,protein binding,cadherin binding,sequence-specific single stranded DNA bindingkcytoplasmic mRNA processing body,nucleoplasm,cytoplasm,cytosol,membrane,nuclear speck,extracellular exosome\>sp|Q15365|PCBP1_HUMAN Poly(rC)-binding protein 1 OS=Homo sapiens OX=9606 GN=PCBP1 PE=1 SV=2P58107EPPK1 EPIPL_HUMAN EpiplakinIbiological_process,negative regulation of keratinocyte proliferation,negative regulation of cell migration,wound healing,intermediate filament organization,negative regulation of epithelial cell proliferation,negative regulation of keratinocyte migration,negative regulation of wound healing,regulation of epithelium regenerationFRNA binding,cytoskeletal protein binding,intermediate filament bindingcytoplasm,cytoskeleton,bicellular tight junction,basolateral plasma membrane,apicolateral plasma membrane,hemidesmosome,cell projection,keratin filament,cell periphery,perinucleolar compartmentK>sp|P58107|EPIPL_HUMAN Epiplakin OS=Homo sapiens OX=9606 GN=EPPK1 PE=1 SV=3P61421ATP6V0D1 VA0D1_HUMAN V-type proton ATPase subunit d 1brain development,insulin receptor signaling pathway,ATP hydrolysis coupled proton transport,proton transport,regulation of macroautophagy,transferrin transport,ion transmembrane transport,IRE1-mediated unfolded protein response,cilium morphogenesis,phagosome acidificationeprotein binding,hydrogen-exporting ATPase activity, phosphorylative mechanism,protein complex bindinglysosomal membrane,early endosome,synaptic vesicle,endosome membrane,membrane,apical plasma membrane,vacuolar proton-transporting V-type ATPase complex,phagocytic vesicle membrane,proton-transporting V-type ATPase, V0 domain,axon terminus,extracellular exosome,centrosomee>sp|P61421|VA0D1_HUMAN V-type proton ATPase subunit d 1 OS=Homo sapiens OX=9606 GN=ATP6V0D1 PE=1 SV=1P54802NAGLU ANAG_HUMANAlpha-N-acetylglucosaminidaseglycosaminoglycan catabolic process,lysosome organization,nervous system development,cerebellar Purkinje cell layer development,middle ear morphogenesis,locomotor rhythm,retinal rod cell development,inner ear receptor cell development&alpha-N-acetylglucosaminidase activity.lysosome,lysosomal lumen,extracellular exosome^>sp|P54802|ANAG_HUMAN Alpha-N-acetylglucosaminidase OS=Homo sapiens OX=9606 GN=NAGLU PE=1 SV=2Q12846STX4 STX4_HUMAN Syntaxin-4intracellular protein transport,post-Golgi vesicle-mediated transport,positive regulation of cell proliferation,regulation of exocytosis,positive regulation of cell migration,synaptic vesicle fusion to presynaptic active zone membrane,response to hydroperoxide,SNARE complex assembly,positive regulation of insulin secretion involved in cellular response to glucose stimulus,positive regulation of catalytic activity,positive regulation of eosinophil degranulation,positive regulation of cell adhesion,vesicle docking,organelle fusion,positive regulation of chemotaxis,positive regulation of immunoglobulin secretion,long-term synaptic potentiation,positive regulation of establishment of protein localization to plasma membrane,regulation of extrinsic apoptotic signaling pathway via death domain receptors,positive regulation of protein localization to plasma membrane,vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane,positive regulation of protein localization to cell surfacegSNARE binding,SNAP receptor activity,protein binding,sphingomyelin phosphodiesterase activator activitystorage vacuole,extracellular space,intracellular,endosome,vacuole,trans-Golgi network,cytosol,plasma membrane,synaptic vesicle,cell surface,membrane,integral component of membrane,basolateral plasma membrane,lamellipodium,phagocytic vesicle membrane,SNARE complex,myelin sheath adaxonal region,som< atodendritic compartment,specific granule,dendritic spine,lateral loop,synapse,perinuclear region of cytoplasm,extracellular exosomeJ>sp|Q12846|STX4_HUMAN Syntaxin-4 OS=Homo sapiens OX=9606 GN=STX4 PE=1 SV=2Q9H2V7SPNS1 SPNS1_HUMANProtein spinster homolog 1\sphingosine-1-phosphate signaling pathway,lipid transport,locomotion,transmembrane transport1protein binding,sphingolipid transporter activityVmitochondrial inner membrane,lysosomal membrane,integral component of membrane,vesicle\>sp|Q9H2V7|SPNS1_HUMAN Protein spinster homolog 1 OS=Homo sapiens OX=9606 GN=SPNS1 PE=1 SV=1Q06481APLP2 APLP2_HUMANAmyloid-like protein 2qplatelet degranulation,G-protein coupled receptor signaling pathway,negative regulation of endopeptidase activityDNA binding,serine-type endopeptidase inhibitor activity,protein binding,heparin binding,identical protein binding,transition metal ion bindingunucleus,plasma membrane,membrane,integral component of membrane,platelet alpha granule membrane,extracellular exosomeX>sp|Q06481|APLP2_HUMAN Amyloid-like protein 2 OS=Homo sapiens OX=9606 GN=APLP2 PE=1 SV=2O14558HSPB6 HSPB6_HUMANHeat shock protein beta-6regulation of muscle contraction,negative regulation of cardiac muscle cell apoptotic process,positive regulation of angiogenesis,chaperone-mediated protein foldingstructural constituent of eye lens,protein binding,protein homodimerization activity,unfolded protein binding,chaperone binding&extracellular region,nucleus,cytoplasm[>sp|O14558|HSPB6_HUMAN Heat shock protein beta-6 OS=Homo sapiens OX=9606 GN=HSPB6 PE=1 SV=2O43657TSPAN6 TSN6_HUMAN Tetraspanin-6cell surface receptor signaling pathway,negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway,positive regulation of I-kappaB kinase/NF-kappaB signaling,negative regulation of NIK/NF-kappaB signalingO>sp|O43657|TSN6_HUMAN Tetraspanin-6 OS=Homo sapiens OX=9606 GN=TSPAN6 PE=1 SV=1P27482CALML3 CALL3_HUMANCalmodulin-like protein 3\>sp|P27482|CALL3_HUMAN Calmodulin-like protein 3 OS=Homo sapiens OX=9606 GN=CALML3 PE=1 SV=2Q92896GLG1 GSLG1_HUMANGolgi apparatus protein 1negative regulation of protein processing,negative regulation of transforming growth factor beta receptor signaling pathway,regulation of chondrocyte differentiation,leukocyte migration,bone morphogenesis1receptor binding,fibroblast growth factor bindingGolgi membrane,proteinaceous extracellular matrix,Golgi apparatus,plasma membrane,membrane,integral component of membrane,extracellular exosomeZ>sp|Q92896|GSLG1_HUMAN Golgi apparatus protein 1 OS=Homo sapiens OX=9606 GN=GLG1 PE=1 SV=2O60884DNAJA2 DNJA2_HUMAN!DnaJ homolog subfamily A member 2spositive regulation of cell proliferation,response to heat,positive regulation of ATPase activity,protein refoldingATPase activator activity,protein binding,ATP binding,heat shock protein binding,metal ion binding,unfolded protein binding,chaperone bindingd>sp|O60884|DNJA2_HUMAN DnaJ homolog subfamily A member 2 OS=Homo sapiens OX=9606 GN=DNAJA2 PE=1 SV=1P31944CASP14 CASPE_HUMAN Caspase-14[proteolysis,epidermis development,keratinization,cornification,execution phase of apoptosisendopeptidase activity,cysteine-type endopeptidase activity,protein binding,cysteine-type endopeptidase activity involved in execution phase of apoptosisUnucleus,cytoplasm,cytosol,extracellular matrix,keratin filament,extracellular exosomeM>sp|P31944|CASPE_HUMAN Caspase-14 OS=Homo sapiens OX=9606 GN=CASP14 PE=1 SV=2P13473LAMP2 LAMP2_HUMAN+Lysosome-associated membrane glycoprotein 2hplatelet degranulation,protein targeting,cellular response to starvation,protein import,regulation of protein stability,neutrophil degranulation,muscle cell cellular homeostasis,protein stabilization,chaperone-mediated autophagy,protein targeting to lysosome involved in chaperone-mediated autophagy,autophagosome maturation,lysosomal protein catabolic process>protein binding,enzyme binding,protein domain specific bindingYextracellular space,lysosome,lysosomal membrane,late endosome,plasma membrane,membrane,phagocytic vesicle membrane,platelet dense granule membrane,late endosome membrane,azurophil granule membrane,lysosomal lumen,autolysosome,extracellular exosome,integral component of autophagosome membrane,ficolin-1-rich granule membrane,membrane microdomainm>sp|P13473|LAMP2_HUMAN Lysosome-associated membrane glycoprotein 2 OS=Homo sapiens OX=9606 GN=LAMP2 PE=1 SV=2P53634CTSC CATC_HUMANDipeptidyl peptidase 1T cell mediated cytotoxicity,proteolysis,ER to Golgi vesicle-mediated transport,apoptotic process,immune response,aging,response to organic substance,neutrophil degranulation,COPII vesicle coating,proteolysis involved in cellular protein catabolic process,positive regulation of proteolysis involved in cellular protein catabolic process,positive regulation of apoptotic signaling pathway!cysteine-type endopeptidase activity,serine-type endopeptidase activity,protein binding,cysteine-type peptidase activity,peptidase activator activity involved in apoptotic process,phosphatase binding,chloride ion binding,identical protein binding,protein self-association,chaperone binding/Golgi membrane,extracellular region,extracellular space,nucleoplasm,lysosome,endoplasmic reticulum lumen,centrosome,membrane,ER to Golgi transport vesicle,endoplasmic reticulum-Golgi intermediate compartment membrane,azurophil granule lumen,intracellular membrane-bounded organelle,extracellular exosomeV>sp|P53634|CATC_HUMAN Dipeptidyl peptidase 1 OS=Homo sapiens OX=9606 GN=CTSC PE=1 SV=2P06702S100A9 S10A9_HUMANProtein S100-A9cytokine production,toll-like receptor signaling pathway,leukocyte migration involved in inflammatory response,positive regulation of peptide secretion,regulation of translation,autophagy,apoptotic process,activation of cysteine-type endopeptidase activity involved in apoptotic process,inflammatory response,cell-cell signaling,astrocyte development,antimicrobial humoral response,positive regulation of blood coagulation,positive regulation of cell growth,neutrophil chemotaxis,actin cytoskeleton reorganization,sequestering of zinc ion,chemokine production,peptidyl-cysteine S-trans-nitrosylation,defense response to bacterium,neutrophil degranulation,innate immune response,regulation of integrin biosynthetic process,positive regulation of inflammatory response,defense response to fungus,positive regulation of NF-kappaB transcription factor activity,regulation of cytoskeleton organization,neutrophil aggregation,cellular oxidant detoxification,positive regulation of intrinsic apoptotic signaling pathwaysignal transducer activity,calcium ion binding,protein binding,microtubule binding,zinc ion binding,antioxidant activity,Toll-like receptor 4 binding,arachidonic acid binding,RAGE receptor bindingextracellular region,extracellular space,nucleus,nucleoplasm,cytosol,cytoskeleton,plasma membrane,cell junction,extracellular matrix,secretory granule lumen,extracellular exosomeR>sp|P06702|S10A9_HUMAN Protein S100-A9 OS=Homo sapiens OX=9606 GN=S100A9 PE=1 SV=1Q08188TGM3 TGM3_HUMAN-Protein-glutamine gamma-glutamyltransferase Ecellular protein modification process,peptide cross-linking,keratinocyte differentiation,hair follicle morphogenesis,keratinization,cell envelope organization,protein tetramerizationprotein-glutamine gamma-glutamyltransferase activity,catalytic activity,calcium ion binding,transferase activity, transferring acyl groupsZcytoplasm,extrinsic component of cytoplasmic side of plasma membrane,extracellular exosomem>sp|Q08188|TGM3_HUMAN Protein-glutamine gamma-glutamyltransferase E OS=Homo sapiens OX=9606 GN=TGM3 PE=1 SV=4P00450CP CERU_HUMAN CeruloplasminNcopper ion transport,cellular iron ion homeostasis,oxidation-reduction process9ferroxidase activity,copper ion binding,chaperone bindingeextracellular region,extracellular space,lysosomal membrane,extracellular exosome,blood microparticleK>sp|P00450|CERU_HUMAN Ceruloplasmin OS=Homo sapiens OX=9606 GN=CP PE=1 SV=1P28070PSMB4< PSB4_HUMANProteasome subunit beta type-4MAPK cascade,protein polyubiquitination,stimulatory C-type lectin receptor signaling pathway,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent,negative regulation of inflammatory response to antigenic stimulus,regulation of cellular amino acid metabolic process,negative regulation of G2/M transition of mitotic cell cycle,viral process,protein deubiquitination,anaphase-promoting complex-dependent catabolic process,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process,tumor necrosis factor-mediated signaling pathway,NIK/NF-kappaB signaling,Fc-epsilon receptor signaling pathway,proteasome-mediated ubiquitin-dependent protein catabolic process,regulation of mRNA stability,T cell receptor signaling pathway,negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition,transmembrane transport,Wnt signaling pathway, planar cell polarity pathway,regulation of transcription from RNA polymerase II promoter in response to hypoxia,negative regulation of canonical Wnt signaling pathway,positive regulation of canonical Wnt signaling pathwayPlipopolysaccharide binding,threonine-type endopeptidase activity,protein binding\proteasome complex,nucleus,nucleoplasm,cytosol,proteasome core complex,extracellular exosome_>sp|P28070|PSB4_HUMAN Proteasome subunit beta type-4 OS=Homo sapiens OX=9606 GN=PSMB4 PE=1 SV=4P38646HSPA9 GRP75_HUMAN Stress-70 protein, mitochondrialprotein folding,protein export from nucleus,erythrocyte differentiation,negative regulation of apoptotic process,negative regulation of erythrocyte differentiation,negative regulation of hematopoietic stem cell differentiationaRNA binding,protein binding,ATP binding,ubiquitin protein ligase binding,unfolded protein bindingnucleolus,cytoplasm,mitochondrion,focal adhesion,extracellular matrix,mitochondrial nucleoid,myelin sheath,extracellular exosomeb>sp|P38646|GRP75_HUMAN Stress-70 protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPA9 PE=1 SV=2P20930FLG FILA_HUMAN Filaggrinkmulticellular organism development,keratinocyte differentiation,establishment of skin barrier,cornification]structural molecule activity,calcium ion binding,protein binding,transition metal ion bindingcnucleus,cytosol,intermediate filament,keratohyalin granule,intracellular membrane-bounded organelleH>sp|P20930|FILA_HUMAN Filaggrin OS=Homo sapiens OX=9606 GN=FLG PE=1 SV=3P06865HEXA HEXA_HUMAN!Beta-hexosaminidase subunit alphacarbohydrate metabolic process,glycosaminoglycan biosynthetic process,glycosphingolipid metabolic process,chondroitin sulfate catabolic process,hyaluronan catabolic process,keratan sulfate catabolic processobeta-N-acetylhexosaminidase activity,acetylglucosaminyltransferase activity,protein heterodimerization activity@membrane,azurophil granule,lysosomal lumen,extracellular exosomea>sp|P06865|HEXA_HUMAN Beta-hexosaminidase subunit alpha OS=Homo sapiens OX=9606 GN=HEXA PE=1 SV=2P08476INHBA INHBA_HUMANInhibin beta A chainBG1/S transition of mitotic cell cycle,ovarian follicle development,hair follicle development,hematopoietic progenitor cell differentiation,regulation of transcription from RNA polymerase II promoter,defense response,cell cycle arrest,cell surface receptor signaling pathway,cell-cell signaling,nervous system development,negative regulation of cell proliferation,male gonad development,positive regulation of gene expression,positive regulation of pathway-restricted SMAD protein phosphorylation,striatal medium spiny neuron differentiation,cell differentiation,erythrocyte differentiation,negative regulation of cell growth,positive regulation of cellular protein metabolic process,activin receptor signaling pathway,endodermal cell differentiation,negative regulation of phosphorylation,odontogenesis,response to drug,hemoglobin biosynthetic process,progesterone secretion,regulation of MAPK cascade,negative regulation of interferon-gamma biosynthetic process,negative regulation of B cell differentiation,positive regulation of erythrocyte differentiation,negative regulation of macrophage differentiation,negative regulation of cell cycle,positive regulation of transcription, DNA-templated,positive regulation of transcription from RNA polymerase II promoter,regulation of follicle-stimulating hormone secretion,positive regulation of follicle-stimulating hormone secretion,negative regulation of follicle-stimulating hormone secretion,mesodermal cell differentiation,cell development,palate development,positive regulation of ovulation,SMAD protein signal transduction,eyelid development in camera-type eye,cellular response to follicle-stimulating hormone stimulus,cellular response to cholesterol,GABAergic neuron differentiation,extrinsic apoptotic signaling pathway,positive regulation of extrinsic apoptotic signaling pathway in absence of ligandcytokine activity,transforming growth factor beta receptor binding,hormone activity,protein binding,growth factor activity,peptide hormone binding,inhibin binding,identical protein binding,protein heterodimerization activity,type II activin receptor bindingXextracellular region,activin A complex,inhibin A complex,perinuclear region of cytoplasmV>sp|P08476|INHBA_HUMAN Inhibin beta A chain OS=Homo sapiens OX=9606 GN=INHBA PE=1 SV=2Q9Y4F1FARP1 FARP1_HUMAN7FERM, ARHGEF and pleckstrin domain-containing protein 1synapse assembly,negative regulation of phosphatase activity,regulation of Rho protein signal transduction,positive regulation of GTPase activity,dendrite morphogenesiszRho guanyl-nucleotide exchange factor activity,cytoskeletal protein binding,Rac guanyl-nucleotide exchange factor activitycytosol,cytoskeleton,cell junction,filopodium,dendrite,extrinsic component of cytoplasmic side of plasma membrane,dendritic spiney>sp|Q9Y4F1|FARP1_HUMAN FERM, ARHGEF and pleckstrin domain-containing protein 1 OS=Homo sapiens OX=9606 GN=FARP1 PE=1 SV=1P07737PFN1 PROF1_HUMAN Profilin-1neural tube closure,positive regulation of epithelial cell migration,actin cytoskeleton organization,negative regulation of actin filament polymerization,positive regulation of actin filament polymerization,negative regulation of actin filament bundle assembly,positive regulation of actin filament bundle assembly,positive regulation of ATPase activity,positive regulation of transcription from RNA polymerase II promoter,positive regulation of viral transcription,protein stabilization,positive regulation of DNA metabolic process,positive regulation of stress fiber assembly,negative regulation of stress fiber assembly,Wnt signaling pathway, planar cell polarity pathway,cellular response to growth factor stimulus,positive regulation of ruffle assemblyadenyl-nucleotide exchange factor activity,RNA binding,actin binding,actin monomer binding,receptor binding,protein binding,phosphatidylinositol-4,5-bisphosphate binding,Rho GTPase binding,cadherin binding,proline-rich region bindingnucleus,cytoplasm,cytosol,cytoskeleton,focal adhesion,cell cortex,membrane,neuron projection,synapse,extracellular exosome,blood microparticleK>sp|P07737|PROF1_HUMAN Profilin-1 OS=Homo sapiens OX=9606 GN=PFN1 PE=1 SV=2P02788LTF TRFL_HUMANLactotransferrinsossification,regulation of cytokine production,retina homeostasis,innate immune response in mucosa,transcription, DNA-templated,proteolysis,ion transport,humoral immune response,antimicrobial humoral response,antibacterial humoral response,antifungal humoral response,negative regulation of lipopolysaccharide-mediated signaling pathway,regulation of tumor necrosis factor production,negative regulation of ATPase activity,iron assimilation by chelation and transport,positive regulation of osteoblast proliferation,positive regulation of toll-like receptor 4 signaling pathway,negative regulation of apoptotic process,positive regulation of I-kappaB kinase/NF-kappaB signaling,neutrophil degranulation,cellular protein metabolic process,nega< tive regulation by host of viral process,negative regulation of viral genome replication,positive regulation of osteoblast differentiation,negative regulation of viral process,positive regulation of NF-kappaB transcription factor activity,bone morphogenesis,positive regulation of protein serine/threonine kinase activity,positive regulation of bone mineralization involved in bone maturation,negative regulation of single-species biofilm formation in or on host organism,positive regulation of chondrocyte proliferation,negative regulation of tumor necrosis factor (ligand) superfamily member 11 production,negative regulation of osteoclast developmentDNA binding,serine-type endopeptidase activity,iron ion binding,protein binding,heparin binding,protein serine/threonine kinase activator activityextracellular region,extracellular space,nucleus,cytoplasm,cell surface,secretory granule,specific granule lumen,specific granule,protein complex,extracellular exosome,phagocytic vesicle lumen,tertiary granule lumenO>sp|P02788|TRFL_HUMAN Lactotransferrin OS=Homo sapiens OX=9606 GN=LTF PE=1 SV=6Q96BM9ARL8A ARL8A_HUMAN'ADP-ribosylation factor-like protein 8Achromosome segregation,mitotic nuclear division,small GTPase mediated signal transduction,neutrophil degranulation,cell divisionVGTPase activity,protein binding,GTP binding,alpha-tubulin binding,beta-tubulin bindingcytoplasm,lysosomal membrane,plasma membrane,membrane,midbody,late endosome membrane,azurophil granule membrane,spindle midzone,extracellular exosome,ficolin-1-rich granule membranei>sp|Q96BM9|ARL8A_HUMAN ADP-ribosylation factor-like protein 8A OS=Homo sapiens OX=9606 GN=ARL8A PE=1 SV=1Q96P63 SERPINB12 SPB12_HUMAN Serpin B12hematopoietic progenitor cell differentiation,negative regulation of endopeptidase activity,negative regulation of protein catabolic process,neutrophil degranulation;serine-type endopeptidase inhibitor activity,enzyme bindingcextracellular space,cytoplasm,plasma membrane,extracellular exosome,ficolin-1-rich granule membraneP>sp|Q96P63|SPB12_HUMAN Serpin B12 OS=Homo sapiens OX=9606 GN=SERPINB12 PE=1 SV=1P08134RHOC RHOC_HUMAN$Rho-related GTP-binding protein RhoC3cytokinesis,small GTPase mediated signal transduction,positive regulation of I-kappaB kinase/NF-kappaB signaling,apical junction assembly,wound healing, spreading of cells,regulation of small GTPase mediated signal transduction,positive regulation of lipase activity,skeletal muscle satellite cell migration6signal transducer activity,protein binding,GTP bindingEnucleus,cytosol,plasma membrane,cleavage furrow,extracellular exosomed>sp|P08134|RHOC_HUMAN Rho-related GTP-binding protein RhoC OS=Homo sapiens OX=9606 GN=RHOC PE=1 SV=1P35222CTNNB1 CTNB1_HUMANCatenin beta-1Mnegative regulation of transcription from RNA polymerase II promoter,embryonic axis specification,cell morphogenesis involved in differentiation,patterning of blood vessels,branching involved in ureteric bud morphogenesis,in utero embryonic development,gastrulation with mouth forming second,cell fate specification,endodermal cell fate commitment,neuron migration,epithelial to mesenchymal transition,neural plate development,positive regulation of neuroblast proliferation,positive regulation of mesenchymal cell proliferation,lens morphogenesis in camera-type eye,regulation of secondary heart field cardioblast proliferation,metanephros morphogenesis,negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis,transcription, DNA-templated,cell adhesion,cell-matrix adhesion,Wnt signaling pathway, calcium modulating pathway,chemical synaptic transmission,ectoderm development,glial cell fate determination,negative regulation of cell proliferation,anterior/posterior axis specification,dorsal/ventral axis specification,proximal/distal pattern formation,positive regulation of epithelial to mesenchymal transition,positive regulation of heparan sulfate proteoglycan biosynthetic process,Wnt signaling pathway,single organismal cell-cell adhesion,stem cell population maintenance,layer formation in cerebral cortex,central nervous system vasculogenesis,osteoclast differentiation,androgen receptor signaling pathway,male genitalia development,hindbrain development,regulation of centriole-centriole cohesion,pancreas development,hair follicle morphogenesis,regulation of myelination,positive regulation of telomere maintenance via telomerase,negative regulation of chondrocyte differentiation,response to estradiol,positive regulation of type I interferon production,T cell differentiation in thymus,negative regulation of protein sumoylation,adherens junction assembly,protein localization to cell surface,embryonic heart tube development,genitalia morphogenesis,embryonic forelimb morphogenesis,embryonic hindlimb morphogenesis,hair cell differentiation,catenin import into nucleus,entry of bacterium into host cell,embryonic skeletal limb joint morphogenesis,regulation of T cell proliferation,odontogenesis of dentin-containing tooth,response to drug,embryonic digit morphogenesis,positive regulation of apoptotic process,positive regulation of I-kappaB kinase/NF-kappaB signaling,proteasome-mediated ubiquitin-dependent protein catabolic process,positive regulation of MAPK cascade,positive regulation of neuron apoptotic process,canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition,canonical Wnt signaling pathway involved in negative regulation of apoptotic process,bone resorption,positive regulation of endothelial cell differentiation,positive regulation of osteoblast differentiation,negative regulation of osteoclast differentiation,positive regulation of fibroblast growth factor receptor signaling pathway,regulation of angiogenesis,negative regulation of transcription, DNA-templated,positive regulation of transcription, DNA-templated,positive regulation of transcription from RNA polymerase II promoter,negative regulation of mitotic cell cycle, embryonic,chromatin-mediated maintenance of transcription,regulation of fibroblast proliferation,cell maturation,synaptic vesicle transport,thymus development,oocyte development,embryonic foregut morphogenesis,positive regulation of skeletal muscle tissue development,regulation of smooth muscle cell proliferation,negative regulation of oligodendrocyte differentiation,regulation of neurogenesis,synapse organization,positive regulation of sequence-specific DNA binding transcription factor activity,smooth muscle cell differentiation,positive regulation of muscle cell differentiation,positive regulation of histone H3-K4 methylation,positive regulation of telomerase activity,oviduct development,canonical Wnt signaling pathway,trachea formation,epithelial tube branching involved in lung morphogenesis,lung cell differentiation,lung-associated mesenchyme development,lung induction,epithelial cell differentiation involved in prostate gland development,positive regulation of epithelial cell proliferation involved in prostate gland development,hair follicle placode formation,mesenchymal cell proliferation involved in lung development,endothelial tube morphogenesis,fungiform papilla formation,canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation,sympathetic ganglion development,cranial ganglion development,regulation of centromeric sister chromatid cohesion,cellular response to growth factor stimulus,cellular response to indole-3-methanol,renal vesicle formation,renal inner medulla development,renal outer medulla development,nephron tubule formation,regulation of nephron tubule epithelial cell differentiation,regulation of calcium ion import,negative regulation of oxidative stress-induced neuron death,positive regulation of chromatin-mediated maintenance of transcription,regulation of euchromatin binding,positive regulation of core promoter binding,beta-catenin-TCF complex assembly,beta-catenin destruction complex disassembly,cranial skeletal system development,midbrain dopaminergic neuron differentiation,canonical Wnt signaling pathway involved in midbrain dopaminergic neuron< differentiation,embryonic brain development,dorsal root ganglion development,regulation of protein localization to cell surface,positive regulation of determination of dorsal identity,positive regulation of DNA-templated transcription, initiation,negative regulation of apoptotic signaling pathwayRNA polymerase II core promoter sequence-specific DNA binding,RNA polymerase II transcription factor binding,RNA polymerase II activating transcription factor binding,chromatin binding,transcription factor activity, sequence-specific DNA binding,transcription coactivator activity,signal transducer activity,protein binding,protein C-terminus binding,transcription factor binding,enzyme binding,kinase binding,protein kinase binding,protein phosphatase binding,estrogen receptor binding,nuclear hormone receptor binding,transcription regulatory region DNA binding,ion channel binding,alpha-catenin binding,cadherin binding,SMAD binding,protein heterodimerization activity,androgen receptor binding,I-SMAD binding,repressing transcription factor bindingspindle pole,nucleus,nucleoplasm,transcription factor complex,nuclear euchromatin,cytoplasm,centrosome,cytosol,plasma membrane,cell-cell junction,adherens junction,cell-cell adherens junction,fascia adherens,bicellular tight junction,focal adhesion,cell cortex,membrane,basolateral plasma membrane,lateral plasma membrane,catenin complex,flotillin complex,Z disc,lamellipodium,cell junction,beta-catenin destruction complex,microvillus membrane,protein-DNA complex,Scrib-APC-beta-catenin complex,protein complex,apical part of cell,synapse,perinuclear region of cytoplasm,extracellular exosome,beta-catenin-TCF7L2 complex,cell periphery,beta-catenin-TCF complex,Wnt signalosomeQ>sp|P35222|CTNB1_HUMAN Catenin beta-1 OS=Homo sapiens OX=9606 GN=CTNNB1 PE=1 SV=1O75882ATRN ATRN_HUMAN Attractininflammatory response,response to oxidative stress,cerebellum development,regulation of multicellular organism growth,myelination,pigmentation&receptor activity,carbohydrate bindingiextracellular space,cytoplasm,plasma membrane,integral component of plasma membrane,extracellular exosomeI>sp|O75882|ATRN_HUMAN Attractin OS=Homo sapiens OX=9606 GN=ATRN PE=1 SV=2P01889HLA-B HLAB_HUMAN5HLA class I histocompatibility antigen, B alpha chainv>sp|P01889|HLAB_HUMAN HLA class I histocompatibility antigen, B alpha chain OS=Homo sapiens OX=9606 GN=HLA-B PE=1 SV=3Q15084PDIA6 PDIA6_HUMANProtein disulfide-isomerase A6protein folding,response to endoplasmic reticulum stress,IRE1-mediated unfolded protein response,apoptotic cell clearance,cell redox homeostasisendoplasmic reticulum,endoplasmic reticulum lumen,endoplasmic reticulum membrane,endoplasmic reticulum-Golgi intermediate compartment,cytosol,plasma membrane,endoplasmic reticulum chaperone complex,melanosome,extracellular exosome`>sp|Q15084|PDIA6_HUMAN Protein disulfide-isomerase A6 OS=Homo sapiens OX=9606 GN=PDIA6 PE=1 SV=1Q9C0H2TTYH3 TTYH3_HUMANProtein tweety homolog 3Ochloride transport,ion transmembrane transport,chloride transmembrane transportSintracellular calcium activated chloride channel activity,chloride channel activity>plasma membrane,chloride channel complex,extracellular exosomeZ>sp|Q9C0H2|TTYH3_HUMAN Protein tweety homolog 3 OS=Homo sapiens OX=9606 GN=TTYH3 PE=1 SV=3Q7Z794KRT77 K2C1B_HUMAN Keratin, type II cytoskeletal 1b/biological_process,keratinization,cornification;cytosol,cytoskeleton,keratin filament,extracellular exosomeb>sp|Q7Z794|K2C1B_HUMAN Keratin, type II cytoskeletal 1b OS=Homo sapiens OX=9606 GN=KRT77 PE=1 SV=3O00462MANBA MANBA_HUMANBeta-mannosidase`cellular protein modification process,oligosaccharide catabolic process,neutrophil degranulation)beta-mannosidase activity,mannose bindingcplasma membrane,azurophil granule membrane,lysosomal lumen,intracellular membrane-bounded organelleR>sp|O00462|MANBA_HUMAN Beta-mannosidase OS=Homo sapiens OX=9606 GN=MANBA PE=1 SV=3P35221CTNNA1 CTNA1_HUMANCatenin alpha-1Kovarian follicle development,actin filament organization,cell adhesion,establishment or maintenance of cell polarity,negative regulation of neuroblast proliferation,aging,male gonad development,gap junction assembly,axon regeneration,adherens junction organization,cellular protein localization,odontogenesis of dentin-containing tooth,apical junction assembly,response to estrogen,positive regulation of smoothened signaling pathway,positive regulation of muscle cell differentiation,protein heterooligomerization,cellular response to indole-3-methanol,epithelial cell-cell adhesion,negative regulation of cell motility,negative regulation of integrin-mediated signaling pathway,negative regulation of extrinsic apoptotic signaling pathway in absence of ligand,positive regulation of extrinsic apoptotic signaling pathway in absence of ligandRNA binding,structural molecule activity,protein binding,beta-catenin binding,vinculin binding,gamma-catenin binding,cadherin binding,protein heterodimerization activity,actin filament bindingacrosomal vesicle,Golgi apparatus,cytosol,plasma membrane,cell-cell junction,zonula adherens,focal adhesion,intercalated disc,actin cytoskeleton,catenin complex,flotillin complex,lamellipodium,cell junction,intracellular membrane-bounded organelleR>sp|P35221|CTNA1_HUMAN Catenin alpha-1 OS=Homo sapiens OX=9606 GN=CTNNA1 PE=1 SV=1P08195SLC3A2 4F2_HUMAN$4F2 cell-surface antigen heavy chaincarbohydrate metabolic process,tryptophan catabolic process,calcium ion transport,amino acid transport,tryptophan transport,cell growth,sodium ion transmembrane transport,response to exogenous dsRNA,leukocyte migration,leucine importRNA binding,double-stranded RNA binding,catalytic activity,calcium:sodium antiporter activity,protein binding,neutral amino acid transmembrane transporter activity,cadherin bindingnucleus,cytosol,plasma membrane,cell surface,membrane,integral component of membrane,apical plasma membrane,melanosome,extracellular exosomee>sp|P08195|4F2_HUMAN 4F2 cell-surface antigen heavy chain OS=Homo sapiens OX=9606 GN=SLC3A2 PE=1 SV=3P00338LDHA LDHA_HUMANL-lactate dehydrogenase A chain\response to hypoxia,lactate metabolic process,pyruvate metabolic process,glycolytic process,response to nutrient,response to glucose,NAD metabolic process,response to drug,response to hydrogen peroxide,positive regulation of apoptotic process,response to estrogen,post-embryonic animal organ development,response to cAMP,oxidation-reduction processvL-lactate dehydrogenase activity,protein binding,kinase binding,identical protein binding,cadherin binding,NAD binding.nucleus,cytosol,membrane,extracellular exosome_>sp|P00338|LDHA_HUMAN L-lactate dehydrogenase A chain OS=Homo sapiens OX=9606 GN=LDHA PE=1 SV=2P02768ALB ALBU_HUMANAlbuminretina homeostasis,platelet degranulation,transport,receptor-mediated endocytosis,cellular response to starvation,bile acid and bile salt transport,hemolysis by symbiont of host erythrocytes,lipoprotein metabolic process,negative regulation of apoptotic process,negative regulation of programmed cell death,sodium-independent organic anion transport,maintenance of mitochondrion location,cellular oxidant detoxificationDNA binding,fatty acid binding,copper ion binding,protein binding,drug binding,toxic substance binding,antioxidant activity,pyridoxal phosphate binding,identical protein binding,chaperone binding,oxygen bindingextracellular region,extracellular space,nucleus,endoplasmic reticulum,Golgi apparatus,platelet alpha granule lumen,myelin sheath,protein complex,extracellular exosome,blood microparticleF>sp|P02768|ALBU_HUMAN Albumin OS=Homo sapiens OX=9606 GN=ALB PE=1 SV=266 proteins are up-regulated.!1078 proteins are down-regulated.MiDAS7710 elements included exclusively in "IR_Exosome SASP":7433 elements included exclusively in "IR_soluble SASP":?152 common elements in "IR_Exosome SASP" and "IR_soluble SASP":FBLCLASP1KPNA1TRAPPC6BCAMK2BCXCL1CXCL8PSMB1RSF1CLPXAGAP3HPLNPEPGFM1CPOXAURKAIP1< CSTF2TPGGT1B HIST1H2BKTCAF1MIFCFHR2DSTNR3C1MT2AMRTO4IGFBP2LACTBTBC1D4EPM2AIP1CALM1GPLD1NRD1BTDAK2ABCF1GLRXCAND2UPF2PRPS2XPNPEP3PTGES3LAD1DDX39AUTRNNAA25PCHK1GTF3C5COQ6MATR3MOSTSPAN9 HIST1H2ABMLLT1RABEP2DPYSTXNDC17AAMDCTXNL1IMMTCPQKIF1BSUMO1EEF1A1ACTBNUP93SDAD1H2AZ1RBM7FHOD1ECDPCCANEK1VPS33BPHC2ACOT9EGFCDC34TXLNGGNL2MTHFD2THOC5DARS2NUMBERCC6LPPP1CCTXLNALRBANaNTOR1AIP1SUCLA2RALBP1SLC33A1GSTT1ACAP1TRRAPACBD3ALDH1B1BMS1CPSF1MYL12BPTPN13BAG3RRM2BYEATS4LCKCDS2RAB38RBMS2TBCADDX19APPIDNUFIP2VILLCHD4AUHTMEM259AOC3CLASP2PLEKHA7VWA8IPO9MORC3SURF2PCDH1ITPR1MRPS5CC2D1BGOLGA1HBDFBXL18DDAH1ALDH1L2RASA3RNPS1PPIP5K2MTMR12PRODH2PFDN6AKR1C4UFD1LEIF4EBP1OPTNCBWD7NOP14NEDD1CDK16MAPK14ITGAXTBC1D7UQCRBBLZF1IGFBP4SART1IRS2GRIP1SNRPBEHBP1SPECC1LATP5F1CAB39ATP6V1C2PRKAG3ATOX1ZCCHC3DARSEHHADHNOMO3LARP7PANK2PPATADSLCTSZDMGDHHSPA1ALRPPRCRPEL1FTCDPOTEFGLYR1VARSDOCK11IGF2SPIN1BTKMOB1BNUP85DOCK8MUC13VPS39HSPA4LDIDO1CLUHPAFAH2IMPA1FBP1SMARCA4PDZK1P1GGT3PASCC3ITCHPIGKIDH3BSULT1B1PSMB6CPTPHK2AIMP1USF2RB1ARHGEF12DNASE2NCF2HMGA1FAHU2AF1L5HMGB1CSRP2PUM2NELFCDAARSCMTM6IRF5ETFARIC8BSKIV2L2IARS2URB1RPS4Y1TWSG1SORBS3SAMD4AMTMR3WDR37RBM3PROCRHMGN2GOLGB1SERPINA1SYNPOACTBL2SETD3FTSJ3NME2GAAENO3RPS21TPM2RICTORNUTF2ATF7IPELAVL1COG1NCOA5GP5CASP12DENND4ATCEB1TWF1CHMP4APRPF38ACSNK1A1GNB2L1IL18GLO1C9orf152RPL26KRT73QARSQPRTPPIHSOD1RBBP4TALDO1ALYREFDHFRACTA2MSH2SH3BGRL3STIM2DBIPRPF8CTGFCST3ACAP2LRP8PAIP1BCL2L13STMN1UBE2V1SLKCDAA1BGHN1KIAA0930API5ZNF750MRPL53 CTTNBP2NLTANC1 C14orf166KLF4S100A7THUMPD1PRSS2SOD3KIAA1671TYMSGTF2F2IFI35EIF3CLHBE1AMY1B/30 common elements in "IR", "Doxo" and "miDAS": 387 proteins are down-regulated.P00491PNP PNPH_HUMANPurine nucleoside phosphorylasenucleobase-containing compound metabolic process,inosine catabolic process,purine nucleotide catabolic process,nicotinamide riboside catabolic process,immune response,NAD biosynthesis via nicotinamide riboside salvage pathway,urate biosynthetic process,positive regulation of T cell proliferation,response to drug,purine-containing compound salvage,neutrophil degranulation,positive regulation of alpha-beta T cell differentiation,interleukin-2 secretionxnucleoside binding,purine nucleobase binding,purine-nucleoside phosphorylase activity,drug binding,phosphate ion bindingextracellular region,intracellular,nucleus,cytoplasm,cytosol,cytoskeleton,secretory granule lumen,extracellular exosome,ficolin-1-rich granule lumen^>sp|P00491|PNPH_HUMAN Purine nucleoside phosphorylase OS=Homo sapiens OX=9606 GN=PNP PE=1 SV=2P00738 HPT_HUMAN HaptoglobinDreceptor-mediated endocytosis,defense response,acute-phase response,positive regulation of cell death,response to hydrogen peroxide,defense response to bacterium,neutrophil degranulation,negative regulation of oxidoreductase activity,cellular oxidant detoxification,negative regulation of hydrogen peroxide catabolic process7protein binding,antioxidant activity,hemoglobin bindingextracellular region,extracellular space,haptoglobin-hemoglobin complex,specific granule lumen,extracellular exosome,endocytic vesicle lumen,blood microparticle,tertiary granule lumenH>sp|P00738|HPT_HUMAN Haptoglobin OS=Homo sapiens OX=9606 GN=HP PE=1 SV=1P00742F10 FA10_HUMANCoagulation factor Xsignal peptide processing,ER to Golgi vesicle-mediated transport,blood coagulation,blood coagulation, intrinsic pathway,blood coagulation, extrinsic pathway,peptidyl-glutamic acid carboxylation,positive regulation of cell migration,positive regulation of protein kinase B signaling[serine-type endopeptidase activity,calcium ion binding,protein binding,phospholipid bindingextracellular region,endoplasmic reticulum lumen,Golgi lumen,plasma membrane,intrinsic component of external side of plasma membraneS>sp|P00742|FA10_HUMAN Coagulation factor X OS=Homo sapiens OX=9606 GN=F10 PE=1 SV=2P01009 A1AT_HUMANAlpha-1-antitrypsinplatelet degranulation,ER to Golgi vesicle-mediated transport,acute-phase response,blood coagulation,negative regulation of endopeptidase activity,neutrophil degranulation,COPII vesicle coating|glycoprotein binding,protease binding,serine-type endopeptidase inhibitor activity,protein binding,identical protein bindingqGolgi membrane,extracellular region,proteinaceous extracellular matrix,extracellular space,endoplasmic reticulum,endoplasmic reticulum lumen,Golgi apparatus,ER to Golgi transport vesicle,platelet alpha granule lumen,endoplasmic reticulum-Golgi intermediate compartment membrane,intracellular membrane-bounded organelle,extracellular exosome,ficolin-1-rich granule lumenW>sp|P01009|A1AT_HUMAN Alpha-1-antitrypsin OS=Homo sapiens OX=9606 GN=SERPINA1 PE=1 SV=3P01019AGT ANGT_HUMANAngiotensinogen9regulation of cell growth,positive regulation of cytokine production,kidney development,blood vessel remodeling,angiotensin maturation,regulation of blood volume by renin-angiotensin,renin-angiotensin regulation of aldosterone production,regulation of renal output by angiotensin,regulation of heart rate,regulation of blood vessel size by renin-angiotensin,renal system process,angiotensin-mediated drinking behavior,positive regulation of extracellular matrix constituent secretion,cellular sodium ion homeostasis,cell surface receptor signaling pathway,G-protein coupled receptor signaling pathway,G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger,phospholipase C-activating G-protein coupled receptor signaling pathway,activation of phospholipase C activity,positive regulation of cytosolic calcium ion concentration,nitric oxide mediated signal transduction,cell-cell signaling,female pregnancy,aging,regulation of blood pressure,positive regulation of activation of JAK2 kinase activity,positive regulation of endothelial cell migration,positive regulation of cardiac muscle hypertrophy,positive regulation of cardiac muscle cell apoptotic process,positive regulation of macrophage derived foam cell differentiation,positive regulation of cholesterol esterification,negative regulation of endopeptidase activity,regulation of norepinephrine secretion,positive regulation of phosphatidylinositol 3-kinase signaling,artery smooth muscle contraction,response to muscle activity involved in regulation of muscle adaptation,negative regulation of angiogenesis,regulation of vasoconstriction,negative regulation of cell growth,positive regulation of cellular protein metabolic process,positive regulation of superoxide anion generation,positive regulation of NAD(P)H oxidase activity,negative regulation of tissue remodeling,low-density lipoprotein particle remodeling,catenin import into nucleus,regulation of renal sodium excretion,positive regulation of renal sodium excretion,regulation of cell proliferation,vasodilation,positive regulation of nitric oxide biosynthetic process,positive regulation of epidermal growth factor receptor signaling pathway,positive regulation of blood pressure,positive regulation of transcription, DNA-templated,fibroblast proliferation,positive regulation of fibroblast proliferation,regulation of long-term neuronal synaptic plasticity,smooth muscle cell proliferation,cytokine secretion,positive regulation of inflammatory response,positive regulation of peptidyl-tyrosine phosphorylation,positive regulation of NF-kappaB transcription factor activity,ne< gative regulation of neurotrophin TRK receptor signaling pathway,stress-activated MAPK cascade,regulation of calcium ion transport,regulation of transmission of nerve impulse,cell growth involved in cardiac muscle cell development,positive regulation of protein tyrosine kinase activity,ERK1 and ERK2 cascade,uterine smooth muscle contraction,cellular response to mechanical stimulus,positive regulation of branching involved in ureteric bud morphogenesis,regulation of extracellular matrix assembly,positive regulation of L-arginine import into cell,positive regulation of gap junction assembly,regulation of cardiac conduction,positive regulation of vascular smooth muscle cell proliferation,positive regulation of vascular associated smooth muscle cell migration,positive regulation of L-lysine import into cell,positive regulation of reactive oxygen species metabolic process,positive regulation of extrinsic apoptotic signaling pathway,positive regulation of glucose import in response to insulin stimulusserine-type endopeptidase inhibitor activity,hormone activity,protein binding,growth factor activity,type 1 angiotensin receptor binding,type 2 angiotensin receptor bindingZextracellular region,extracellular space,cytosol,extracellular exosome,blood microparticleN>sp|P01019|ANGT_HUMAN Angiotensinogen OS=Homo sapiens OX=9606 GN=AGT PE=1 SV=1 P01857;P0DOX5IGHG1;IGHG1_HUMAN;IGG1_HUMANHImmunoglobulin heavy constant gamma 1;Immunoglobulin gamma-1 heavy chain;proteolysis,phagocytosis, recognition,phagocytosis, engulfment,complement activation,complement activation, classical pathway,Fc-gamma receptor signaling pathway involved in phagocytosis,defense response to bacterium,innate immune response,B cell receptor signaling pathway,positive regulation of B cell activation;cantigen binding,serine-type endopeptidase activity,protein binding,immunoglobulin receptor binding;extracellular region,extracellular space,external side of plasma membrane,immunoglobulin complex, circulating,extracellular exosome,blood microparticle;>sp|P01857|IGHG1_HUMAN Immunoglobulin heavy constant gamma 1 OS=Homo sapiens OX=9606 GN=IGHG1 PE=1 SV=1;>sp|P0DOX5|IGG1_HUMAN Immunoglobulin gamma-1 heavy chain OS=Homo sapiens OX=9606 PE=1 SV=2P01860IGHG3 IGHG3_HUMAN%Immunoglobulin heavy constant gamma 3Mretina homeostasis,proteolysis,phagocytosis, recognition,phagocytosis, engulfment,complement activation,complement activation, classical pathway,Fc-gamma receptor signaling pathway involved in phagocytosis,defense response to bacterium,innate immune response,B cell receptor signaling pathway,positive regulation of B cell activationg>sp|P01860|IGHG3_HUMAN Immunoglobulin heavy constant gamma 3 OS=Homo sapiens OX=9606 GN=IGHG3 PE=1 SV=2P02647APOA1 APOA1_HUMANApolipoprotein A-Iretinoid metabolic process,regulation of protein phosphorylation,endothelial cell proliferation,platelet degranulation,negative regulation of cytokine secretion involved in immune response,phosphatidylcholine biosynthetic process,cholesterol biosynthetic process,receptor-mediated endocytosis,G-protein coupled receptor signaling pathway,integrin-mediated signaling pathway,response to nutrient,cholesterol metabolic process,glucocorticoid metabolic process,negative regulation of tumor necrosis factor-mediated signaling pathway,positive regulation of cholesterol esterification,positive regulation of triglyceride catabolic process,negative regulation of very-low-density lipoprotein particle remodeling,peripheral nervous system axon regeneration,protein oxidation,peptidyl-methionine modification,triglyceride catabolic process,lipid storage,regulation of intestinal cholesterol absorption,cholesterol transport,adrenal gland development,animal organ regeneration,neuron projection regeneration,regulation of Cdc42 protein signal transduction,cholesterol efflux,phospholipid efflux,negative regulation of heterotypic cell-cell adhesion,high-density lipoprotein particle remodeling,high-density lipoprotein particle assembly,high-density lipoprotein particle clearance,positive regulation of Rho protein signal transduction,lipoprotein metabolic process,lipoprotein biosynthetic process,response to drug,cholesterol homeostasis,blood vessel endothelial cell migration,response to estrogen,reverse cholesterol transport,cellular protein metabolic process,positive regulation of fatty acid biosynthetic process,negative regulation of interleukin-1 beta secretion,negative regulation of inflammatory response,protein stabilization,negative chemotaxis,positive regulation of lipoprotein lipase activity,vitamin transport,positive regulation of hydrolase activity,positive regulation of stress fiber assembly,transmembrane transport,phospholipid homeostasis,negative regulation of lipase activity,negative regulation of cell adhesion molecule production,negative regulation of response to cytokine stimulus,triglyceride homeostasis,cholesterol import,positive regulation of substrate adhesion-dependent cell spreading,transforming growth factor beta receptor signaling pathway,ERK1 and ERK2 cascadebeta-amyloid binding,protein binding,phospholipid binding,phospholipid transporter activity,high-density lipoprotein particle binding,cholesterol binding,cholesterol transporter activity,enzyme binding,phosphatidylcholine binding,apolipoprotein receptor binding,apolipoprotein A-I receptor binding,identical protein binding,chemorepellent activity,lipase inhibitor activity,phosphatidylcholine-sterol O-acyltransferase activator activity,high-density lipoprotein particle receptor bindingextracellular region,extracellular space,nucleus,early endosome,endoplasmic reticulum lumen,cytosol,plasma membrane,cell surface,endocytic vesicle,cytoplasmic vesicle,very-low-density lipoprotein particle,high-density lipoprotein particle,discoidal high-density lipoprotein particle,spherical high-density lipoprotein particle,secretory granule lumen,chylomicron,extracellular exosome,endocytic vesicle lumen,blood microparticle,extracellular vesicleT>sp|P02647|APOA1_HUMAN Apolipoprotein A-I OS=Homo sapiens OX=9606 GN=APOA1 PE=1 SV=1P02790HPX HEMO_HUMAN Hemopexinpositive regulation of immunoglobulin production,positive regulation of humoral immune response mediated by circulating immunoglobulin,cellular iron ion homeostasis,receptor-mediated endocytosis,heme transport,viral process,hemoglobin metabolic process,heme metabolic process,positive regulation of tyrosine phosphorylation of Stat1 protein,positive regulation of interferon-gamma-mediated signaling pathway;protein binding,heme transporter activity,metal ion bindingjextracellular region,extracellular space,extracellular exosome,endocytic vesicle lumen,blood microparticleH>sp|P02790|HEMO_HUMAN Hemopexin OS=Homo sapiens OX=9606 GN=HPX PE=1 SV=2P04196HRG HRG_HUMANHistidine-rich glycoprotein(angiogenesis,platelet degranulation,positive regulation of immune response to tumor cell,chemotaxis,negative regulation of cell adhesion,negative regulation of cell proliferation,regulation of gene expression,regulation of platelet activation,negative regulation of lamellipodium assembly,negative regulation of endopeptidase activity,heme transport,negative regulation of angiogenesis,platelet activation,regulation of blood coagulation,negative regulation of cell growth,regulation of actin cytoskeleton organization,negative regulation of cell adhesion mediated by integrin,fibrinolysis,positive regulation of apoptotic process,regulation of protein complex assembly,negative regulation of blood vessel endothelial cell migration,regulation of peptidyl-tyrosine phosphorylation,defense response to fungus,positive regulation of focal adhesion assembly,negative regulation of fibrinolysis,negative regulation of vascular endothelial growth factor signaling pathway,positive regulation of blood vessel remodeling,negative regulation of endothelial cell chemotaxisserine-type endopeptidase inhibitor activity,cysteine-type endopeptidase inhibitor activity,receptor binding,protein binding,heparin binding,zinc ion binding,immunoglobulin binding,heme binding,heparan sulfate proteoglycan binding,metal ion binding< xextracellular region,plasma membrane,platelet alpha granule lumen,endolysosome,extracellular exosome,blood microparticleY>sp|P04196|HRG_HUMAN Histidine-rich glycoprotein OS=Homo sapiens OX=9606 GN=HRG PE=1 SV=1P09496CLTA CLCA_HUMANClathrin light chain Aintracellular protein transport,receptor-mediated endocytosis,microtubule-based movement,mitotic nuclear division,antigen processing and presentation of exogenous peptide antigen via MHC class II,cell division,membrane organization,clathrin-dependent endocytosislmolecular_function,structural molecule activity,protein binding,clathrin heavy chain binding,peptide bindingspindle,cytosol,plasma membrane,membrane,clathrin coat,clathrin vesicle coat,clathrin coat of trans-Golgi network vesicle,clathrin coat of coated pit,cytoplasmic vesicle,trans-Golgi network membrane,endolysosome membrane,clathrin complexV>sp|P09496|CLCA_HUMAN Clathrin light chain A OS=Homo sapiens OX=9606 GN=CLTA PE=1 SV=1P10253 LYAG_HUMANLysosomal alpha-glucosidasemaltose metabolic process,regulation of the force of heart contraction,diaphragm contraction,heart morphogenesis,glycogen catabolic process,sucrose metabolic process,glucose metabolic process,lysosome organization,locomotory behavior,tissue development,vacuolar sequestering,neutrophil degranulation,muscle cell cellular homeostasis,neuromuscular process controlling posture,neuromuscular process controlling balance,cardiac muscle contractionualpha-1,4-glucosidase activity,oligo-1,6-glucosidase activity,carbohydrate binding,maltose alpha-glucosidase activitylysosome,lysosomal membrane,plasma membrane,membrane,azurophil granule membrane,lysosomal lumen,extracellular exosome,tertiary granule membrane,ficolin-1-rich granule membraneZ>sp|P10253|LYAG_HUMAN Lysosomal alpha-glucosidase OS=Homo sapiens OX=9606 GN=GAA PE=1 SV=4P11169SLC2A3 GTR3_HUMANASolute carrier family 2, facilitated glucose transporter member 3carbohydrate metabolic process,glucose transport,L-ascorbic acid metabolic process,neutrophil degranulation,dehydroascorbic acid transport,glucose transmembrane transportglucose transmembrane transporter activity,glucose binding,dehydroascorbic acid transporter activity,D-glucose transmembrane transporter activityplasma membrane,integral component of plasma membrane,integral component of membrane,secretory granule membrane,specific granule membrane,extracellular exosome,tertiary granule membrane,ficolin-1-rich granule membrane>sp|P11169|GTR3_HUMAN Solute carrier family 2, facilitated glucose transporter member 3 OS=Homo sapiens OX=9606 GN=SLC2A3 PE=1 SV=1P12081HARS1 HARS1_HUMAN#Histidine--tRNA ligase, cytoplasmicntranslation,tRNA aminoacylation for protein translation,histidyl-tRNA aminoacylation,mitochondrial translation*histidine-tRNA ligase activity,ATP bindingcytoplasm,mitochondrion,cytosole>sp|P12081|HARS1_HUMAN Histidine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=HARS1 PE=1 SV=2P13010XRCC5 XRCC5_HUMAN*X-ray repair cross-complementing protein 5telomere maintenance,double-strand break repair,double-strand break repair via nonhomologous end joining,DNA recombination,transcription, DNA-templated,brain development,cell proliferation,positive regulation of type I interferon production,DNA duplex unwinding,response to drug,neutrophil degranulation,negative regulation of transcription, DNA-templated,regulation of smooth muscle cell proliferation,positive regulation of neurogenesis,hematopoietic stem cell differentiation,cellular response to fatty acid,cellular hyperosmotic salinity response,cellular response to gamma radiation,cellular response to X-ray,establishment of integrated proviral latency,negative regulation of t-circle formationtDNA binding,damaged DNA binding,double-stranded DNA binding,RNA binding,ATP-dependent DNA helicase activity,protein binding,ATP binding,protein C-terminus binding,ubiquitin protein ligase binding,telomeric DNA binding,transcription regulatory region DNA binding,macromolecular complex binding,double-stranded telomeric DNA binding,5'-deoxyribose-5-phosphate lyase activitynuclear telomere cap complex,nuclear chromosome, telomeric region,extracellular region,nucleus,nucleoplasm,nucleolus,cytosol,plasma membrane,membrane,secretory granule lumen,Ku70:Ku80 complex,nonhomologous end joining complexl>sp|P13010|XRCC5_HUMAN X-ray repair cross-complementing protein 5 OS=Homo sapiens OX=9606 GN=XRCC5 PE=1 SV=3P19013KRT4 K2C4_HUMANKeratin, type II cytoskeletal 4cytoskeleton organization,epithelial cell differentiation,keratinization,negative regulation of epithelial cell proliferation,cornificationfnucleus,cytosol,intermediate filament,cell surface,keratin filament,intermediate filament cytoskeleton_>sp|P19013|K2C4_HUMAN Keratin, type II cytoskeletal 4 OS=Homo sapiens OX=9606 GN=KRT4 PE=1 SV=5P19320VCAM1 VCAM1_HUMAN Vascular cell adhesion protein 1Wresponse to hypoxia,acute inflammatory response,chronic inflammatory response,cell adhesion,heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules,leukocyte cell-cell adhesion,cell-matrix adhesion,aging,response to nutrient,amine metabolic process,response to zinc ion,response to ionizing radiation,viral process,membrane to membrane docking,B cell differentiation,extracellular matrix organization,response to lipopolysaccharide,response to nicotine,calcium-mediated signaling using intracellular calcium source,cellular response to vascular endothelial growth factor stimulus,positive regulation of T cell proliferation,response to ethanol,regulation of immune response,leukocyte tethering or rolling,oxidation-reduction process,cell chemotaxis,interferon-gamma-mediated signaling pathway,cellular response to tumor necrosis factorNintegrin binding,primary amine oxidase activity,cell adhesion molecule binding:podosome,extracellular space,early endosome,endoplasmic reticulum,Golgi apparatus,plasma membrane,microvillus,external side of plasma membrane,cell surface,integral component of membrane,filopodium,sarcolemma,apical part of cell,extracellular exosome,alpha9-beta1 integrin-vascular cell adhesion molecule-1 complexb>sp|P19320|VCAM1_HUMAN Vascular cell adhesion protein 1 OS=Homo sapiens OX=9606 GN=VCAM1 PE=1 SV=1P19652ORM2 A1AG2_HUMANAlpha-1-acid glycoprotein 2hplatelet degranulation,regulation of immune system process,acute-phase response,neutrophil degranulationextracellular region,extracellular space,platelet alpha granule lumen,azurophil granule lumen,specific granule lumen,extracellular exosome,blood microparticle\>sp|P19652|A1AG2_HUMAN Alpha-1-acid glycoprotein 2 OS=Homo sapiens OX=9606 GN=ORM2 PE=1 SV=2P19827ITIH1 ITIH1_HUMAN,Inter-alpha-trypsin inhibitor heavy chain H1@serine-type endopeptidase inhibitor activity,calcium ion bindingn>sp|P19827|ITIH1_HUMAN Inter-alpha-trypsin inhibitor heavy chain H1 OS=Homo sapiens OX=9606 GN=ITIH1 PE=1 SV=3P20618 PSB1_HUMANProteasome subunit beta type-1MAPK cascade,protein polyubiquitination,stimulatory C-type lectin receptor signaling pathway,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent,regulation of cellular amino acid metabolic process,negative regulation of G2/M transition of mitotic cell cycle,viral process,protein deubiquitination,anaphase-promoting complex-dependent catabolic process,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process,tumor necrosis factor-mediated signaling pathway,NIK/NF-kappaB signaling,Fc-epsilon receptor signaling pathway,proteasome-mediated ubiquitin-dependent protein catabolic process,neutrophil degranulation,regulation of mRNA stability,T cell receptor signaling pathway,negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition,transmembrane transport,Wnt signaling pathway, planar cell polarity pathway,regulation of transcription from RNA polymerase II promoter in response to hypoxia,negative regulation of canonical Wnt signaling pathway,positive r< egulation of canonical Wnt signaling pathway_>sp|P20618|PSB1_HUMAN Proteasome subunit beta type-1 OS=Homo sapiens OX=9606 GN=PSMB1 PE=1 SV=2P28072 PSB6_HUMANProteasome subunit beta type-6Mendopeptidase activity,threonine-type endopeptidase activity,cadherin binding_>sp|P28072|PSB6_HUMAN Proteasome subunit beta type-6 OS=Homo sapiens OX=9606 GN=PSMB6 PE=1 SV=4P31151 S10A7_HUMANProtein S100-A7response to reactive oxygen species,angiogenesis,epidermis development,positive regulation of T cell chemotaxis,antimicrobial humoral response,keratinocyte differentiation,response to lipopolysaccharide,neutrophil degranulation,innate immune response,defense response to Gram-negative bacterium,sequestering of metal ion,positive regulation of ERK1 and ERK2 cascade,positive regulation of granulocyte chemotaxis,positive regulation of monocyte chemotaxisJcalcium ion binding,protein binding,zinc ion binding,RAGE receptor bindingextracellular region,nucleus,cytoplasm,endoplasmic reticulum,cytosol,focal adhesion,azurophil granule lumen,extracellular exosomeR>sp|P31151|S10A7_HUMAN Protein S100-A7 OS=Homo sapiens OX=9606 GN=S100A7 PE=1 SV=4P47929LGALS7 LEG7_HUMAN Galectin-7]apoptotic process,heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculescarbohydrate bindingL>sp|P47929|LEG7_HUMAN Galectin-7 OS=Homo sapiens OX=9606 GN=LGALS7 PE=1 SV=2P48163ME1 MAOX_HUMANNADP-dependent malic enzymecarbohydrate metabolic process,pyruvate metabolic process,malate metabolic process,NADP biosynthetic process,response to hormone,response to carbohydrate,protein tetramerization,oxidation-reduction process,regulation of NADP metabolic processmalic enzyme activity,malate dehydrogenase (decarboxylating) (NAD+) activity,malate dehydrogenase (decarboxylating) (NADP+) activity,oxaloacetate decarboxylase activity,electron carrier activity,manganese ion binding,ADP binding,NADP binding,NAD bindingZ>sp|P48163|MAOX_HUMAN NADP-dependent malic enzyme OS=Homo sapiens OX=9606 GN=ME1 PE=1 SV=1P58335ANTXR2 ANTR2_HUMANAnthrax toxin receptor 2$reproductive process,toxin transport3receptor activity,protein binding,metal ion bindingextracellular region,endoplasmic reticulum membrane,plasma membrane,external side of plasma membrane,endosome membrane,integral component of membrane[>sp|P58335|ANTR2_HUMAN Anthrax toxin receptor 2 OS=Homo sapiens OX=9606 GN=ANTXR2 PE=1 SV=5P61626LYZ LYSC_HUMAN Lysozyme Cretina homeostasis,inflammatory response,antimicrobial humoral response,cytolysis,defense response to bacterium,neutrophil degranulation,cellular protein metabolic process+lysozyme activity,identical protein bindingextracellular region,extracellular space,azurophil granule lumen,specific granule lumen,extracellular exosome,tertiary granule lumenI>sp|P61626|LYSC_HUMAN Lysozyme C OS=Homo sapiens OX=9606 GN=LYZ PE=1 SV=1P61769B2M B2MG_HUMANBeta-2-microglobulin,retina homeostasis,positive regulation of T cell mediated cytotoxicity,antigen processing and presentation of peptide antigen via MHC class I,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent,antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent,positive regulation of T cell cytokine production,regulation of membrane depolarization,negative regulation of neuron projection development,antibacterial humoral response,antigen processing and presentation of endogenous peptide antigen via MHC class I,positive regulation of protein binding,T cell differentiation in thymus,ferric iron import,protein refolding,response to drug,neutrophil degranulation,cellular protein metabolic process,innate immune response,regulation of erythrocyte differentiation,response to cadmium ion,positive regulation of receptor-mediated endocytosis,regulation of defense response to virus by virus,regulation of immune response,defense response to Gram-negative bacterium,defense response to Gram-positive bacterium,iron ion homeostasis,interferon-gamma-mediated signaling pathway,cellular response to lipopolysaccharide,cellular response to iron ion,cellular response to iron(III) ion,negative regulation of receptor binding,positive regulation of receptor binding,positive regulation of ferrous iron import into cell,positive regulation of ferrous iron binding,positive regulation of transferrin receptor binding>glycoprotein binding,protein binding,identical protein bindingGolgi membrane,extracellular region,extracellular space,endoplasmic reticulum lumen,Golgi apparatus,cytosol,plasma membrane,focal adhesion,external side of plasma membrane,ER to Golgi transport vesicle membrane,membrane,phagocytic vesicle membrane,early endosome membrane,early endosome lumen,specific granule lumen,MHC class I protein complex,recycling endosome membrane,extracellular exosome,tertiary granule lumen,HFE-transferrin receptor complexS>sp|P61769|B2MG_HUMAN Beta-2-microglobulin OS=Homo sapiens OX=9606 GN=B2M PE=1 SV=1P81605DCD DCD_HUMAN Dermcidinproteolysis,antimicrobial humoral response,killing of cells of other organism,defense response to bacterium,defense response to fungus.RNA binding,protein binding,peptidase activity?extracellular region,extracellular matrix,extracellular exosomeG>sp|P81605|DCD_HUMAN Dermcidin OS=Homo sapiens OX=9606 GN=DCD PE=1 SV=2Q00796SORD DHSO_HUMANSorbitol dehydrogenaseglucose metabolic process,sorbitol catabolic process,response to osmotic stress,response to hormone,glucuronate catabolic process to xylulose 5-phosphate,flagellated sperm motility,response to nutrient levels,response to drug,fructose biosynthetic process,response to cadmium ion,response to copper ion,L-xylitol catabolic process,L-xylitol metabolic process,oxidation-reduction processL-iditol 2-dehydrogenase activity,zinc ion binding,carbohydrate binding,identical protein binding,D-xylulose reductase activity,NAD binding_extracellular space,cytosol,membrane,motile cilium,mitochondrial membrane,extracellular exosomeV>sp|Q00796|DHSO_HUMAN Sorbitol dehydrogenase OS=Homo sapiens OX=9606 GN=SORD PE=1 SV=4Q01105SET SET_HUMAN Protein SET:DNA replication,nucleosome assembly,nucleosome disassembly,nucleocytoplasmic transport,viral process,negative regulation of histone acetylation,negative regulation of catalytic activity,regulation of mRNA stability,negative regulation of neuron apoptotic process,negative regulation of transcription, DNA-templatedyDNA binding,protein phosphatase inhibitor activity,protein binding,protein phosphatase regulator activity,histone bindingznucleus,nucleoplasm,cytoplasm,endoplasmic reticulum,lipid particle,cytosol,protein complex,perinuclear region of cytoplasmI>sp|Q01105|SET_HUMAN Protein SET OS=Homo sapiens OX=9606 GN=SET PE=1 SV=3Q01628IFITM3 IFM3_HUMAN*Interferon-induced transmembrane protein 3Bimmune response,response to virus,negative regulation of viral transcription,response to interferon-gamma,response to interferon-alpha,response to interferon-beta,negative regulation of viral genome replication,negative regulation of viral entry into host cell,defense response to virus,type I interferon signaling pathwaynlysosomal membrane,plasma membrane,integral component of membrane,late endosome membrane,extracellular exosomel>sp|Q01628|IFM3_HUMAN Interferon-induced transmembrane protein 3 OS=Homo sapiens OX=9606 GN=IFITM3 PE=1 SV=2Q14520HABP2 HABP2_HUMANHyaluronan-binding protein 2proteolysis,cell adhesionPserine-type endopeptidase activity,calcium ion binding,glycosaminoglycan binding^>sp|Q14520|HABP2_HUMAN Hyaluronan-binding protein 2 OS=Homo sapiens OX=9606 GN=HABP2 PE=1 SV=1Q53RT3ASPRV1 APRV1_HUMAN#Retroviral-like aspartic protease 1#protein processing,skin development$aspartic-type endopeptidase activityf>sp|Q53RT3|APRV1_HUMAN Retroviral-like aspartic protease 1 OS=Homo sapiens OX=9606 GN=ASPRV1 PE=1 SV=1Q5TEC6H3-2 H3PS2_HUMANHistone HIST2H3PS2/DNA binding,protein heterodimeriza< tion activitynucleosome,nucleusS>sp|Q5TEC6|H3PS2_HUMAN Histone HIST2H3PS2 OS=Homo sapiens OX=9606 GN=H3-2 PE=1 SV=1Q7Z7M0MEGF8 MEGF8_HUMAN7Multiple epidermal growth factor-like domains protein 8jembryonic heart tube morphogenesis,regulation of gene expression,embryonic limb morphogenesis,BMP signaling pathway,limb morphogenesis,cell migration involved in gastrulation,embryonic skeletal system morphogenesis,positive regulation of axon extension involved in axon guidance,epiboly involved in gastrulation with mouth forming second,embryonic heart tube left/right pattern formation,left/right pattern formation,coronary vasculature development,determination of heart left/right asymmetry,determination of digestive tract left/right asymmetry,craniofacial suture morphogenesis,fasciculation of sensory neuron axon<nucleus,integral component of membrane,extracellular exosomey>sp|Q7Z7M0|MEGF8_HUMAN Multiple epidermal growth factor-like domains protein 8 OS=Homo sapiens OX=9606 GN=MEGF8 PE=1 SV=2Q8WVV4POF1B POF1B_HUMAN Protein POF1B#bicellular tight junction,desmosomeO>sp|Q8WVV4|POF1B_HUMAN Protein POF1B OS=Homo sapiens OX=9606 GN=POF1B PE=1 SV=3Q93050ATP6V0A1 VPP1_HUMAN'V-type proton ATPase 116 kDa subunit a1Tvacuolar acidification,insulin receptor signaling pathway,ATP synthesis coupled proton transport,ATP hydrolysis coupled proton transport,regulation of macroautophagy,transferrin transport,ion transmembrane transport,neutrophil degranulation,vacuolar proton-transporting V-type ATPase complex assembly,phagosome acidification,toxin transportXprotein binding,proton-transporting ATPase activity, rotational mechanism,ATPase bindingvacuolar proton-transporting V-type ATPase, V0 domain,lysosomal membrane,Golgi apparatus,cytosol,plasma membrane,endosome membrane,integral component of membrane,vacuolar proton-transporting V-type ATPase complex,nuclear speck,secretory granule membrane,phagocytic vesicle membrane,melanosome,intracellular membrane-bounded organelle,extracellular exosome,ficolin-1-rich granule membranek>sp|Q93050|VPP1_HUMAN V-type proton ATPase 116 kDa subunit a1 OS=Homo sapiens OX=9606 GN=ATP6V0A1 PE=1 SV=3Q9H299 SH3L3_HUMAN4SH3 domain-binding glutamic acid-rich-like protein 3regulation of actin filament depolymerization,regulation of actin cytoskeleton organization,regulation of blood vessel endothelial cell migration,positive regulation of GTPase activity,cell redox homeostasis,oxidation-reduction processyGTPase activator activity,electron carrier activity,protein disulfide oxidoreductase activity,semaphorin receptor binding:cytoplasm,nuclear body,lamellipodium,extracellular exosomey>sp|Q9H299|SH3L3_HUMAN SH3 domain-binding glutamic acid-rich-like protein 3 OS=Homo sapiens OX=9606 GN=SH3BGRL3 PE=1 SV=1Q9NRX5SERINC1 SERC1_HUMANSerine incorporator 1 phosphatidylserine metabolic process,sphingolipid metabolic process,phospholipid biosynthetic process,L-serine transport,positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity,positive regulation of serine C-palmitoyltransferase activity;protein binding,L-serine transmembrane transporter activitycendoplasmic reticulum membrane,plasma membrane,integral component of membrane,extracellular exosomeY>sp|Q9NRX5|SERC1_HUMAN Serine incorporator 1 OS=Homo sapiens OX=9606 GN=SERINC1 PE=1 SV=1Q9NZT1CALML5 CALL5_HUMANCalmodulin-like protein 5Bsignal transduction,epidermis development,neutrophil degranulationGextracellular region,extracellular exosome,ficolin-1-rich granule lumen\>sp|Q9NZT1|CALL5_HUMAN Calmodulin-like protein 5 OS=Homo sapiens OX=9606 GN=CALML5 PE=1 SV=2Q9NZZ3CHMP5 CHMP5_HUMAN%Charged multivesicular body protein 5cell separation after cytokinesis,regulation of receptor recycling,nucleus organization,lysosome organization,mitotic metaphase plate congression,endosome to lysosome transport,regulation of centrosome duplication,protein transport,endosomal transport,viral life cycle,multivesicular body assembly,viral budding,multivesicular body sorting pathway,regulation of mitotic spindle assembly,ESCRT III complex disassembly7nucleus,cytosol,endosome membrane,extracellular exosomeg>sp|Q9NZZ3|CHMP5_HUMAN Charged multivesicular body protein 5 OS=Homo sapiens OX=9606 GN=CHMP5 PE=1 SV=1Q9P0M6 MACROH2A2 H2AW_HUMANCore histone macro-H2A.2negative regulation of transcription from RNA polymerase II promoter,nucleosome assembly,chromatin silencing,brain development,dosage compensation,chromatin modification,positive regulation of keratinocyte differentiation,negative regulation of gene expression, epigenetic,establishment of protein localization to chromatin,negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter,regulation of cell growthRNA polymerase II regulatory region sequence-specific DNA binding,chromatin DNA binding,transcription regulatory region DNA binding,protein heterodimerization activity~nuclear chromosome, telomeric region,nucleosome,nuclear chromatin,Barr body,nucleoplasm,extracellular exosome,ESC/E(Z) complex]>sp|Q9P0M6|H2AW_HUMAN Core histone macro-H2A.2 OS=Homo sapiens OX=9606 GN=MACROH2A2 PE=1 SV=3Q9UIQ6 LCAP_HUMANLeucyl-cystinyl aminopeptidaseIprotein polyubiquitination,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent,proteolysis,signal transduction,cell-cell signaling,female pregnancy,regulation of blood pressure,protein catabolic process,peptide catabolic process,SMAD protein signal transduction,membrane organizationaminopeptidase activity,protein binding,metallopeptidase activity,zinc ion binding,peptide binding,metalloaminopeptidase activityextracellular region,intracellular,lysosomal membrane,cytosol,plasma membrane,integral component of plasma membrane,membrane,cytoplasmic vesicle membrane,early endosome lumen,perinuclear region of cytoplasm_>sp|Q9UIQ6|LCAP_HUMAN Leucyl-cystinyl aminopeptidase OS=Homo sapiens OX=9606 GN=LNPEP PE=1 SV=3Q9Y287ITM2B ITM2B_HUMANIntegral membrane protein 2Bnervous system development,negative regulation of amyloid precursor protein biosynthetic process,cellular protein metabolic processGolgi membrane,extracellular region,extracellular space,Golgi apparatus,plasma membrane,endosome membrane,membrane,Golgi-associated vesicle membrane,integral component of organelle membrane,intracellular membrane-bounded organelle,extracellular exosome^>sp|Q9Y287|ITM2B_HUMAN Integral membrane protein 2B OS=Homo sapiens OX=9606 GN=ITM2B PE=1 SV=1;1426 protein groups are quantifiable (e" 2 unique peptides).P862 protein groups are significantly altered (Qvalue < 0.05, and Abs.FC > 0.58).P682 protein groups are significantly altered (Qvalue < 0.05, and Abs.FC > 0.58).Q1144 protein groups are significantly altered (Qvalue < 0.05, and Abs.FC > 0.58).Supplementary Table 3A. List of all proteins ( e" 2 unique peptides) identified in IR induced senescent IMR90 cells (IR / Quiescent) .Supplementary Table 3B. List of significantly altered proteins identified in IR induced senescent IMR90 cells (IR / Quiescent).Supplementary Table 3C. List of all proteins ( e" 2 unique peptides) identified in Doxo induced senescent IMR90 cells (Doxo / Quiescent).Supplementary Table 3D. List of significantly altered proteins identified in Doxo induced senescent IMR90 cells (Doxo / Quiescent).Supplementary Table 3E. List of all proteins ( e" 2 unique peptides) identified in MiDAS induced senescent IMR90 cells (MiDAS / Quiescent).pSupplementary Table 3F. List of significantly altered proteins in MiDAS induced IMR90 cells (MiDAS / Quiescent).xSupplementa<ry Table 3G. List of common up-regulated exosome proteins in IR,Doxo and MiDAS induced IMR90 senescent cells.zSupplementary Table 3H. List of common down-regulated exosome proteins in IR,Doxo and MiDAS induced IMR90 senescent cells.ZSupplementary Table 3I. List of common and unique proteins in IR exosome and soluble SASP.Supplementary Table 3J. 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