Research Paper Volume 1, Issue 3 pp 316—327

Oncogenic viral protein HPV E7 up-regulates the SIRT1 longevity protein in human cervical cancer cells

Figure 5. Model for the respective effects of HPV E6 and HPV E7 on human cervical cancer cell survival and proliferation taking into account (A) up-regulation of SIRT1 protein by HPV E7, (B) SIRT1-mediated de-acetylation of p53 and (C) SIRT1 cervical cancer cell survival functions (see text).