Research Paper Volume 1, Issue 3 pp 316—327

Oncogenic viral protein HPV E7 up-regulates the SIRT1 longevity protein in human cervical cancer cells

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Figure 5. Model for the respective effects of HPV E6 and HPV E7 on human cervical cancer cell survival and proliferation taking into account (A) up-regulation of SIRT1 protein by HPV E7, (B) SIRT1-mediated de-acetylation of p53 and (C) SIRT1 cervical cancer cell survival functions (see text).