Figure 5.Schematic diagram of potential SIRT3 action in the skeletal myocyte. Collectively,
our data support a working model in which SIRT3 responds dynamically to
various nutritional and physiological signals to potentially impact muscle
energy homeostasis via AMPK and PGC-1α. Since AMPK can also phosphorylate and activate
CREB [52], SIRT3 may activate CREB directly or through AMPK. Given its
dynamic role, SIRT3 action within the skeletal muscle cells may serve as an
important diagnostic and therapeutic target for impacting human health and
disease.
