Commentary Volume 1, Issue 10 pp 842—844

Awakening p53 in senescent cells using nutlin-3

Figure 1. The p53 signaling pathway in response to genotoxic stress in tumorogenic cells.. (A) The MDM2 inhibitor nutln-3 increases p53-mediated senescence, apoptosis, and cell cycle arrest. (B) The SIRT1 small-molecule inhibitor Tenovin 6 works in tandem with nutlin-3 to induce apoptosis or permanent senescence in cancer cells.