Research Perspective Volume 1, Issue 10 pp 870—874

Dopamine suppresses octopamine signaling in C. elegans: possible involvement of dopamine in the regulation of lifespan

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Figure 1. Regulation of CREB activation in the SIA neurons. In the presence of food, dopamine is released from the dopaminergic neurons and activates the dopamine receptor DOP-3 in the RIC neurons, possibly to decrease octopamine release. Dopamine also inhibits octopamine-mediated signaling in the SIA neurons through the dopamine receptors DOP-2 and DOP-3. In the absence of food, cessation of dopamine signaling results in octopamine-mediated CREB activation through the octopamine receptor SER-3. Exposure to water also induces CREB activation in the SIA neurons independently of dopamine and octopamine.