Research Paper Volume 1, Issue 11 pp 937—948

The circadian clock gene period extends healthspan in aging Drosophila melanogaster

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Figure 4. Neuronal degeneration is accelerated in per01mutants compared to CSp and flies with restored per function (per01{per+}) on day 50. (A) Mean number of vacuoles (with SEM) representing neuronal degeneration was significantly higher in per01mutants compared with wild type CSp and flies with rescued per. Bars with different superscripts are significantly different at p<0.05, data based on 10-15 heads for each genotype. (B-D) Photomicrographs of representative brain sections of CSp, per01, and per01{per+} males. Arrows point to vacuolization.