A Two-tiered compensatory response to loss of DNA repair modulates aging and stress response pathways

Øyvind Fensgård; Henok Kassahun; Izabela Bombik; Torbjørn Rognes; Jessica Margareta Lindvall; Hilde Nilsen

doi:doi:10.18632/aging.100127

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Research Paper Volume 2, Issue 3 pp 133—159

A Two-tiered compensatory response to loss of DNA repair modulates aging and stress response pathways

Figure 1. Overrepresented biological processes in N2 vs. nth-1.. Enriched biological processes in nth-1 vs. N2 are Aging (p < 0.007) and Proteolysis (p < 0.01). The Aging cluster contains 17 genes involved in ILS signaling, including ins-7 and sod-3. Genes responding to stress and steroid signaling are found in the Proteolysis cluster. Genes in red and blue are found to be upregulated and downregulated, respectively.