Research Paper Volume 2, Issue 5 pp 285—297

Circadian clock proteins control adaptation to novel environment and memory formation


Figure 2. Expression of circadian proteins in brain structures. (a) Immunostaining of sagittal brain sections of wt and Bmal-/- mice with BMAL1 specific antibodies. Counterstaining with DAPI was used to detect nuclei. Pyramidal neurons of hippocampal areas CA1 and CA3, granular cells of the dentate gyrus and neurons of subiculum expressing BMAL1 are shown. (b) Circadian profile of Cry1 and Per2 mRNAs in the brain of wt (filled circles) and Bmal1-/- mice (open circles) as measured by real-time PCR. (* p<0.05).