Commentary Volume 2, Issue 5 pp 251—254
The aging clock: to ‘BMAL'icious toward learning and memory
Figure 1. (A) Wild-type (WT) mice exhibit a decrease in exploratory behavior in a novel environment over time, called "Intrasession" habituation, a form of short-term memory (STM). (B) Upon reintroduction to the same environment 24 hours later, WT mice have a further decrease in exploratory behavior, attributable to remembering the previous experience. This is called "Intersession" habituation, and is considered a form of long-term memory (LTM). (C) Bmal1 KO mice fail to display normal Intrasession, and (D) Intersession habituation, suggesting deficits in both STM and LTM.