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Research Paper Volume 2, Issue 6 pp 344—352

The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway

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Figure 6. p53 causes senescence by failing to suppress senescence. (A) Quiescence-prone cells. Upper panel. P53 causes cell cycle arrest and inhibits the mTOR pathway, thus ensuring quiescence. Lower panel. Transduction of cells with shTSC2 activates mTOR thus converting quiescence into senescence. (B) Senescence-prone cells. Upper panel. P53 causes cell cycle arrest without inhibiting the mTOR pathway, thus ensuring senescence. Lower panel. Rapamycin inhibits mTOR thus converting senescence into quiescence.