Commentary Volume 2, Issue 6 pp 327—328
mTOR favors senescence over quiescence in p53-arrested cells
Figure 1. p53-induced senescence or quiescence. Cell stress factors or nutlin-3a activates p53. Rapamycin treatment inhibits mTOR signaling and cells enter a reversible quiescent state. ShTSC2-mediated activation of mTOR sends cells into senescence.