Commentary Volume 2, Issue 7 pp 387—389
Dietary restriction and other lifespan extending pathways converge at the activation of the downstream effector takeout
Figure 1. The study by Bauer et al. places takeout (to) in a central, hub-like regulatory position in the lifespan regulatory network. to might modulate lifespan via different avenues: as a component of the DR pathway (e.g., Indy, Rpd3, Sir2, p53) and by regulating food uptake; by receiving signals from nutritional signaling pathways such as IIS (e.g., chico); by its potential involvement in lipophilic hormone signaling and metabolism (ecdysone [E], juvenile hormone [JH]), for example by regulating JH bioavailability; and by unknown interactions with G protein-coupled receptor signaling (methuselah).