Research Paper Volume 2, Issue 8 pp 504—513
Muscle-specific inositide phosphatase (MIP/MTMR14) is reduced with age and its loss accelerates skeletal muscle aging process by altering calcium homeostasis
Figure 5. Metabolic pathways showing the interconversion of PIPs and putative roles of MIP and PI(3,5)P2. Through the specific action of different phosphatases, seven phosphoinosites molecules are generated. Note that a loss of MIP activity will lead to an increase in PI(3,5)P2 concentration and activity. Even small changes in content or activity of phosphatases and/or their substrates can lead to complex pathologies, including several muscle diseases.