Research Perspective Volume 2, Issue 10 pp 735—741
Epithelial-mesenchymal transition and senescence: two cancer-related processes are crossing paths
Figure 1. Working model schematically depicting how EMT and senescence are linked and contribute to cancer progression. An active oncogene can either induce senescence or EMT, dependent on the cellular context. Conversely, transcription factors like Twist and Zeb1 can have a double impact on cancer progression by simultaneously inhibiting oncogene-induced senescence and promoting EMT.