Figure 3. Additional characterization of iPSCs containing mutations in lamin A/C. (A) Normal karyotype of representative iPSC clones from patients with the 3 diseases. (B) DNA methylation profile of the proximal Oct4 promoter in similar representative clones. Open circles indicate unmethylated CpGs. The respective donor cells were used as control. (C) Teratomas produced from representative iPSC clones from the 3 diseases contain tissues derived from the 3 germ layers.