Figure 6. Effect of hUbb and hUbb+1 over-expression on developmental survival. (A) Frequency of adult flies containing both the rtTA(3)E2 driver and the indicated target transgene that emerged from crosses where larval development was allowed to occur in the presence and absence of DOX, as indicated. Control flies contained no target gene. P values obtained by chi-square test are presented in parentheses. (B) Examples of the pupal-lethal phenotype resulting from hUbb transgenic line cultured +/− DOX, as indicated.