The Werner syndrome helicase protein is required for cell proliferation, immortalization, and tumorigenesis in Scaffold Attachment Factor B1 deficient mice

Sophie Lachapelle; Steffi Oesterreich; Michel Lebel

doi:doi:10.18632/aging.100300

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Research Paper Volume 3, Issue 3 pp 277—290

The Werner syndrome helicase protein is required for cell proliferation, immortalization, and tumorigenesis in Scaffold Attachment Factor B1 deficient mice

Figure 8. Protein levels of p53, p21Waf1, p19Arf, PCNA, p38 kinase, PKCδ, and JNK1 in MEFs. Whole cell lysates from MEFs of each genotype were analyzed by immunoblotting with antibodies against the indicated proteins. Proteins were extracted from wild type, Wrn^Δhel/Δhel, Safb1-null, and Safb1-null/Wrn^Δhel/Δhel MEFs. β-tubulin was used as a loading control.