Research Perspective Volume 3, Issue 4 pp 450—454

Hyperactive when young, hypoactive and overweight when aged: Connecting the dots in the story about locomotor activity, body mass, and aging in Trpv1 knockout mice


Figure 1. Compared to genetically unaltered controls, aged Trpv1−/− mice have a suppressed locomotor activity throughout the day, a lower abdominal temperature during the inactive (light) phase, and a higher abdominal temperature during the active (dark) phase. The locomotor activity and abdominal temperature were measured by telemetry. The mice were kept in their home cages placed inside a climatic chamber; the ambient temperature was maintained at 28°C. The data are shown as means ± SE. Significant changes (P < 5 × 10−2, compared to Trpv1+/+ mice) are marked with asterisks (or horizontal lines with asterisks).