**Figure 4.** **Dermabrasion stimulates fibroblast replication and suppresses senescence in geriatric dermis.** (**A**) Skin biopsies described in Fig. **B**) The density of fibroblasts in the papillary dermis was determined using the Nikon Elements Image Analysis software. Asterisk indicates statistical significance from control values (*p* = 0.0048), two-tailed t-test). (**C**) Sections of biopsies were stained with antibodies to Ki67. The percentage of Ki67(+) fibroblasts in the papillary dermis and the percentage of Ki67(+) keratinocytes in the basal layer of the epidermis were calculated using Nikon Elements image analysis software. Asterisks indicate statistical significance from control values (papillary dermis, *p* = 0.039; epidermis p = 0.058, two-tailed t-test).