Research Paper Volume 3, Issue 6 pp 621—634

Store-Operated Ca2+ Entry (SOCE) Contributes to Normal Skeletal Muscle Contractility in young but not in aged skeletal muscle


Figure 8. Mn+2 quenching of Fura-2 in FDB muscles of young muscle validates the use of BEL as an effective SOCE blocker. Enzymatically dissociated FDB muscle fibers were tested for their SOCE activity using the Mn+2 quenching assay. BEL was able to block most 90% of the SOCE response under these experimental conditions.