Research Paper Volume 3, Issue 6 pp 621—634

Store-Operated Ca2+ Entry (SOCE) Contributes to Normal Skeletal Muscle Contractility in young but not in aged skeletal muscle


Figure 9. Direct visualization of SOCE in mechanically EDL skinned muscle fibers of young and old muscles with BEL reveals robust SOCE in young but compromised SOCE in aged muscle. Confocal imaging of Ca movement from the sealed T-tubules of mechanically skinned muscle fibers from young and aged mice demonstrates that SOCE is fully function in young, but severely ablated in aged muscle fibers.