Research Perspective Volume 3, Issue 6 pp 635—642

SIRT1 and SIRT3 Deacetylate Homologous Substrates: AceCS1,2 and HMGCS1,2


Figure 1. Phylogenetic analysis of the sirtuins. An unrooted tree diagram of the phylogenetic analysis of sirtuin domain sequences, divided into Class I, II, III, IV and U groups. Classes I and IV are further divided into subclasses indicated by lowercase letters. Organism abbreviations: A. act, Actinobacillus actinomycetemcomitans; A. aeo, Aquifex aeolicus; A. ful, Archaeoglobus fulgidus; A. per, Aeropyrum pernix; A. tha, Arabidopsis thaliana; B. per, Bordetella pertussis; B. sub, Bacillus subtilis; C. ace, Clostridium acetabutylicum; C. alb, Candida albicans; C. dif, Clostridium difficile; C. ele, Caenorhabditis elegans; C. jej, Campylobacter jejuni; D. mel, Drosophila melanogaster; D. rad, Deinococcus radiodurans; E. col, Escherichia coli; E. fae, Enterococcus faecalis; H. sap, Homo sapiens; H. pyl, Helicobacter pylori; L. maj, Leishmania major; M. avi, Mycobacterium avium; M. tub, Mycobacterium tuberculosis; O. sat, Oryza sativa; P. aby, Pyrococcus abyssi; P. fal, Plasmodium falciparum; P. hor, Pyrococcus horikoshii; S. aur, Staphylococcus aureus; S. coe, Streptomyces coelicolor; S. pom, Schizosaccharomyces pombe, S. typ, Salmonella typhimurium; S. cer, Saccharomyces cerevisiae; T. bru, Trypanosoma brucei; T. mar, Thermotoga maritima; Y. pes, Yersinia pestis. Adapted from [7].