Research Perspective Volume 3, Issue 6 pp 635—642

SIRT1 and SIRT3 Deacetylate Homologous Substrates: AceCS1,2 and HMGCS1,2


Figure 4. Evolutionary analysis of human sirtuins and their known homologous substrates. Gene family origin and duplication events for SIRT1/SIRT3 and two known homologous substrate families are plotted on the phylogenetic tree. Family origins are indicated by red circles, and duplication events are shown as blue circles.