Research Paper Volume 3, Issue 6 pp 576—583

New comparative genomics approach reveals a conserved health span signature across species


Figure 1. Statistical significance of the overlap between gene lists. Each panel shows the fraction of genes in common between two lists of genes (k/m) as a function of the fraction of genes selected in each list (m/N). The overlaps selected as statistically significant by the list comparison algorithm are marked in red. The top three panels correspond to simulated data, with the inlets representing how list A of genes was shuffled to generate list B. (A) The two lists are completely unrelated: list A was randomly shuffled to generate list B. (B) The two lists are partially related: list A was shuffled with a constrain on the number of ranks a gene could jump to. (C) The two lists are strongly related: same shuffling as in (B), with a stricter constrain. The bottom three panels correspond to list comparisons from datasets in Bauer et al. [6]. (D) The algorithm did not detect any significant overlap when applied to genes up-regulated when Dmp53 activity is diminished in D. melanogaster, and up-regulated genes in the yw, w1118 strain with respect to the Canton-S strain used. (E) The algorithm detected a significant overlap between up-regulated genes in the DR and Sir2 datasets. (F) The algorithm detected a large overlap between DR in two different fly strains (yw, w1118 and Canton-S).