Review Volume 3, Issue 6 pp 565—575

Type 2 Diabetes and the Aging Pancreatic Beta Cell


Figure 3. Effects of p19Arf on the cell cycle. In the absence of p19Arf, p53 is ubiquitinized and subsequently degraded by the proteosome. p19Arf inhibits the ubiquitin-modulated effect of p53 by MDM2. p19Arf inhibits ubiquitin-mediated p53 degradation resulting in induction of p21 and subsequently cell cycle arrest. Adapted from [75] and [76]