Research Paper Volume 3, Issue 11 pp 1098—1109

Tetrahydrocurcumin extends life span and inhibits the oxidative stress response by regulating the FOXO forkhead transcription factor


Figure 4. THC regulates oxidative stress response in Drosophila via foxo activity. Effects of THC, RES, and C on the life span of wild-type (WT, Oregon-R) (A) and foxo mutant (yw background) (B) flies under oxidative stress conditions. Oxidative stress was induced by adding 7.5 mM paraquat to the food. Life span studies were carried out at 25°C with newly eclosed males (M) in each group (20 per vial; 3-4 vials were counted). Survivors were transferred every 2-3 days to fresh vials containing THC, RES, or C (50-150 μM). The statistical analysis of the data is summarized in Table 1.