Research Paper Volume 3, Issue 12 pp 1206—1212

Relationship of spindle assembly checkpoint fidelity to species body mass, lifespan, and developmental rate


Figure 3. Correlation among the spindle assembly checkpoint (SAC) tolerance with several species parameters. The tolerance (defined as a lack of stringency) of the SAC is graphed as percent of cells with >4N DNA content in control cells (panels A, C, E, G, I) or cells treated for 72 h with Colcemid. (panels, B, D, F, H, J). Adult weight, maximum longevity, female sexual maturity, gestation length and postnatal growth rate were all from the AnAge database [22], with the exception of human longevity that was given a value of 90 to account for the fact that human are the only species with a very large available data set and 90 years, which more accurately reflects a value for a random relatively small sample of humans. Measure units are indicated. Postnatal growth rates are expressed in days−1 and, as stated in the AnAge database, they were calculated by fitting empirical data taken from published growth curves to Gompertz function. See legend of Figure 2 and methods section for information on cell treatment.