Research Perspective Volume 4, Issue 4 pp 247—255

Is histone acetylation the most important physiological function for CBP and p300?


Figure 1. The relative location of conserved domains in CBP and p300. NRID (nuclear receptor interaction domain), CH1 (cysteine/histidine-rich region 1, also known as transcriptional-adaptor zinc-finger domain 1 or TAZ1), KIX (kinase inducible domain of CREB interacting domain), Bromodomain (Br), PHD (plant homeodomain), HAT (histone acetyltransferase domain), ZZ (ZZ-type zinc finger domain), TAZ2 (transcriptional-adaptor zinc-finger domain 2; ZZ and TAZ2 together are sometimes referred to as CH3 or cysteine/histidine-rich region 3), and NCBD [nuclear coactivator binding domain or IRF3-binding domain (IBiD)] [26,27,86]. Regions in black indicate the largely nonconserved and unstructured sequences between the conserved domains (white boxes). Locations of Ser436 (Ser437 in humans) in the mouse CBP CH1 domain and Gly422 (Gly421 in humans) in the corresponding position of p300 are indicated. Not drawn to scale.