Research Perspective Volume 4, Issue 7 pp 450—455

Tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression?


Figure 1. Nutlin-3a decreased lipid accumulation during IPTG-induced senescence. HT-p21 cells were treated with IPTG, nutlin-3a and IPTG+nutlin-3a (as indicated) for 3 days as described previously [4-6] and cells were stained with “oil red O” for lipids. In HT-p21 cells, IPTG induces ectopic p21 and senescence. As described previously, nutlin-3a induces endogenous p53 and suppresses IPTG-induced senescence [4-6].