Editorial Volume 5, Issue 7 pp 485—486

Figure 1. let-7 mutations turn back the clock on regeneration in adult neurons. Like many tissues in the body, the ability of neurons to regenerate new axons changes throughout the lifecycle, typically diminishing with age. Inhibiting let-7, or alternatively, increasing the level of its reciprocal inhibitor, lin-41, in adult neurons restored the regeneration capabilities of the larval axons. The dashed green lines indicate the disconnected axons in degeneration. The solid green lines are regenerating axons.