Research Perspective Volume 5, Issue 7 pp 495—506

A healthier approach to clinical trials evaluating resveratrol for primary prevention of age-related diseases in healthy populations


Figure 2. Model comparing expected changes in highly responsive vs. poorly responsive outcome measures to resveratrol treatment in pathological and healthy individuals. The y-axis represents baseline physiologic function, with each dashed line corresponding to the following categories: Letters represent the following: (A) Maximal physiological response attainable through optimal stimulus (i.e., high intensity exercise training, caloric restriction). (B) Healthy normal. (C) Metabolic dysfunction (e.g., diabetes mellitus). For an outcome measure which resveratrol treatment produces a large effect in a pathologic individual, it is expected to show a smaller effect in an already healthy individual. In healthy individuals, highly responsive outcome measures (left) will show a large response to an optimal physiologic stimulus (e.g., high intensity aerobic exercise, caloric restriction), but may have a smaller, yet detectable response, to resveratrol treatment. However, outcome measures which are minimally responsive to such optimal stimuli in the healthy population would be expected to have an undetectable response to resveratrol treatment.