Research Paper Volume 5, Issue 9 pp 643—652

Figure 6. Schematic representation of CD137 – CD137L interactions in age-related myelopoiesis. Depicted is the situation for 12 months old WT, CD137^−/− and CD137L^−/− mice. The absence of CD137 on activated CD4⁺ T cells or of CD137L on hematopoietic progenitor cells leads to a reduced number of myeloid cells in CD137^−/− and CD137L^−/− mice, respectively.