Research Paper Volume 5, Issue 9 pp 643—652

CD137 ligand reverse signaling skews hematopoiesis towards myelopoiesis during aging


Figure 6. Schematic representation of CD137 – CD137L interactions in age-related myelopoiesis. Depicted is the situation for 12 months old WT, CD137−/− and CD137L−/− mice. The absence of CD137 on activated CD4+ T cells or of CD137L on hematopoietic progenitor cells leads to a reduced number of myeloid cells in CD137−/− and CD137L−/− mice, respectively.