Editorial Volume 5, Issue 8 pp 590—591

Figure 1. In aging, expression levels of DPY30 are decreased, which impairs the activity of the MLL/Set1 complex and downregulates ID protein expression. As a consequence, Ets1/2 transcription factors are free to bind to, and activate expression of the INK4/ARF locus. Thereafter, cells exit cell cycle and enter cellular senescence.