Editorial Volume 5, Issue 9 pp 639—640
Pro-senescence therapy for hepatocellular carcinoma
Figure 1. Model for senescence induction in HCC with DLC1 loss. Reconstitution of DLC1 and depletion of MKL1 and 2 induce cellular senescence via activation of MAPK and p16INK4a/pRb pathways (see text for details).