Research Paper Volume 5, Issue 10 pp 759—769
A DNA synthesis inhibitor is protective against proteotoxic stressors via modulation of fertility pathways in Caenorhabditis elegans
Figure 6. Loss of FEM-3 is sufficient to improve proteostasis. A, Loss of fem-3 via RNAi in phsp16.2::GFP animals significantly increases GFP expression compared to control vector (CV) animals after 1-hour heat shock at 35°C. (**=p<0.0001, Student's t-test). B, Loss of fem-3 via RNAi in AM141 animals (Q40) significantly improves motility at day 5 of adulthood compared to CV-treated animals. (*p=.017, Student's t-test).