Editorial Volume 5, Issue 10 pp 721—722

Figure 1. In proliferating primary cells, a proficient miRNA biogenesis machinery maintains the correct balance of miRNA expression, including high levels of senescence-suppressive miRNAs. Upon DGCR8-mediated disruption of miRNA biogenesis, senescence-suppresive miRNAs are down-regulated, leading to activation of a pro-senescent cascade. See text for details and discussion of alternative pathways.