Research Paper Volume 5, Issue 10 pp 770—781

PP2A inhibition results in hepatic insulin resistance despite Akt2 activation


Figure 5. Acutely increased insulin-stimulated signaling through the Akt-FoxO1 node following PP2A inhibition does not result in reduced G6Pase and Pepck protein levels in rat livers. LB1-treatment did not lead to decreased levels of G6Pase (a) nor Pepck (b) protein despite PP2A inhibition resulting in inactivation of FoxO1. Data are averages of western blot quantifications ±SEM. * P<0.05. Representative western blots are shown.