Research Paper Volume 5, Issue 10 pp 770—781

PP2A inhibition results in hepatic insulin resistance despite Akt2 activation


Figure 7. PP2A inhibition by LB1 leads to impaired hepatic insulin-stimulated glycogen synthesis, and, thus, glycogen depletion. Post-clamp glycogen content was significantly reduced in the livers of LB1-treated rats (a). Consistent with this, PP2A inhibition by cantharidin resulted in an impairment of insulin-stimulated glycogen synthesis in primary rat hepatocytes (b). Data are averages ±SEM. * P<0.05.