Research Paper Volume 6, Issue 6 pp 496—510

DNA damage signaling regulates age-dependent proliferative capacity of quiescent inner ear supporting cells


Figure 7. p53 induction in SCs of cochlear explants transduced by AdcD1. (A-B') At 7 DIV, p53 is upregulated in Sox2+ Deiters' cells of P6 cochleas, especially in nuclear doublets and in the large, likely replicating nuclei (arrows). Age-matched utricles show weak or undetectable p53 upregulation. (C,D) In non-infected explants, p53 expression is undetectable. Abbreviations: co, cochlea; AdcD1, adenovirus encoding cyclin D1; utr, utricle. Scale bar, shown in D: A-D, 20 µm.