Research Paper Volume 6, Issue 6 pp 481—495

Interaction between ROS dependent DNA damage, mitochondria and p38 MAPK underlies senescence of human adult stem cells


Figure 2. A rapid DDR activation in H2O2-treated hMESCs. Immunofluorescence analysis of ATM (A), 53BP1 (B) activation and γH2AX foci formation (C) performed at indicated time points after H2O2 addition. DAPI was used as nuclear stain (blue). Representative photomicrographs of the staining are made at original magnification X100. Scale bar is 25 µm.