Research Paper Volume 6, Issue 12 pp 1064—1075

Pathway activation profiling reveals new insights into Age-related Macular Degeneration and provides avenues for therapeutic interventions


Figure 1. Pathway activation strength (PAS) for selected pathways. PAS values have been calculated according to OncoFinder algorithm. PAS presented on this figure passed the following filters PAS<−1.5 and PAS>1.5 in both datasets. Blue bars represent PAS average for each pathway, and error bars represents standard deviation A. PAS derived from GSE50195 dataset. B. PAS derived from GSE50195 that cell-based inflammatory responses within the RPE-choroid are a core feature of AMD. However, cellular sources and targets of pro-inflammatory secreted factors are still need to be determined along with the regulatory mechanism of the chemokine network.