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Research Paper Volume 6, Issue 12 pp 1064—1075

Pathway activation profiling reveals new insights into Age-related Macular Degeneration and provides avenues for therapeutic interventions

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Figure 2. Heatmap of differentially activated pathways shown in Figure 1A. Complement factor H genetic background (rs1061170 SNP) for PAS values derived from GSE50195 dataset shown for high-risk YH/HH and low-risk YY genotype. Blue shading indicates pathway downregulation; red shading indicates pathway upregulation. Samples with names ending in CTRL indicates control samples; samples with names ending in ARM indicates AMD samples.