Research Paper Volume 7, Issue 1 pp 14—25

Functional properties of bone marrow derived multipotent mesenchymal stromal cells are altered in heart failure patients, and could be corrected by adjustment of expansion strategies


Figure 2. Analysis of in vitro proliferation activity of HD and HF BM-MMSC cells seeded at 3000 cells/cm2 and expanded in normoxia (pO2 =20%). (A) The population doubling time (PD) at passage 3; Data are presented as mean +/− SEM; n=16 for HF, and n=10 for HD; ** p <0.03; (B) CFU-F frequency in BM-MMSC samples at successive passages; Data are presented as mean +/− SEM; n=5. (C) The correlation analysis between CFU-F frequency and PD in BM-MMSC samples; (D) BM-MMSC CFU with low (left panel) and high (right panel) proliferation rate; (x50).