Research Paper Volume 7, Issue 1 pp 14—25

Functional properties of bone marrow derived multipotent mesenchymal stromal cells are altered in heart failure patients, and could be corrected by adjustment of expansion strategies


Figure 4. Analysis of expression of genes that regulate regeneration and remodeling in BM-MMSC from HD and HF patients. (A) Visualization of analysis of RT2-PCR expression array results: the blue color bars represent clusters of upregulated genes that control tissue regeneration at different levels; (B) Validation of upregulation of Tgf-beta superfamily genes in HF-derived BM-MMSC; n=10-16, *p<0.02, **p<0.01; (C) Validation of upregulation of extracellular matrix components and remodeling enzymes in HF-derived BM-MMSC; n=10-16; *p<0.001, **p<0.01, ***p<0.05; (D) Validation upregulation of cellular adhesion molecules and regulators of epithelial-to-mesenchymal transition in HF-derived BM-MMSC; n=10-16; *p<0.02; **p<0.002. All data are presented as mean +/− SEM.